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https://www.readbyqxmd.com/read/29161185/medications-for-sleep-schedule-adjustments-in-athletes
#1
Matthew B Baird, Irfan M Asif
CONTEXT: Sleep schedule adjustments are common requirements of modern-day athletes. Many nonpharmacologic and pharmacologic strategies exist to facilitate circadian rhythm shifts to maximize alertness and performance during competition. This review summarizes the evidence for commonly used pharmacologic agents and presents recommendations for the sports medicine provider. EVIDENCE ACQUISITION: MEDLINE searches were performed using the following keywords: sleep aids, circadian rhythm adjustment, athletes and sleep, caffeine and sports, melatonin and athletes, and sleep aids and sports...
November 1, 2017: Sports Health
https://www.readbyqxmd.com/read/29160628/the-role-of-chitin-and-chitosan-in-peripheral-nerve-reconstruction
#2
REVIEW
Michał Bąk, Olga N Gutkowska, Ewa Wagner, Jerzy Gosk
Chitin is a natural polysaccharide commonly found in nature and chitosan is its partially deacetylated derivative. The properties of both biopolymers allow their wide use in medicine and various industries. This paper presents the possibilities offered by chitin and chitosan for the creation of neurotubes utilized in peripheral nerve repair procedures. In the initial part of this manuscript, experimental studies on both polysaccharides carried out by numerous authors have been presented and their results have been discussed...
January 2017: Polimery W Medycynie
https://www.readbyqxmd.com/read/29160497/clinical-indicators-for-nursing-diagnosis-ineffective-protection-in-adolescents-with-cancer
#3
Marília Mendes Nunes, Tânia Alteniza Leandro, Marcos Venícios de Oliveira Lopes, Viviane Martins da Silva
OBJECTIVE: To investigate scientific evidence related to the term protection and clinical indicators and etiologic factors for nursing diagnosis Ineffective protection in adolescents with cancer. METHOD: Integrative literature review in the databases of Scopus, Web of Science, National Library of Medicine and National Institutes of Health (PubMed) and Cochrane; by intersection of the descriptors protection and childhood cancer, which resulted in seven articles. These were insufficient for a comprehension of the term protection and aspects related to its impairment, therefore it was necessary to include a further three reference books...
November 2017: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/29160464/use-of-medicines-by-patients-of-the-primary-health-care-of-the-brazilian-unified-health-system
#4
Clarisse Melo Franco Neves Costa, Micheline Rosa Silveira, Francisco de Assis Acurcio, Augusto Afonso Guerra, Ione Aquemi Guibu, Karen Sarmento Costa, Margô Gomes de Oliveira Karnikowski, Orlando Mario Soeiro, Silvana Nair Leite, Ediná Alves Costa, Renata Cristina Rezende Macedo do Nascimento, Vânia Eloísa de Araújo, Juliana Álvares
OBJECTIVE: To characterize the use of medicines by patients of the primary health care of the Brazilian Unified Health System (SUS). METHODS: This is a cross-sectional, exploratory, and descriptive study, part of the Pesquisa Nacional sobre Acesso, Utilização e Promoção do Uso Racional de Medicamentos - Serviços, 2015 (PNAUM - National Survey on Access, Use and Promotion of Rational Use of Medicines - Services, 2015). Interviews were carried out with patients present in the services by semi-structured questionnaires...
November 13, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/29160457/medicine-dispensing-service-in-primary-health-care-of-sus
#5
Silvana Nair Leite, Noemia Liege Maria da Cunha Bernardo, Juliana Álvares, Augusto Afonso Guerra, Ediná Alves Costa, Francisco de Assis Acurcio, Ione Aquemi Guibu, Karen Sarmento Costa, Margô Gomes de Oliveira Karnikowski, Orlando Mario Soeiro, Luciano Soares
OBJECTIVE: To characterize the medicine dispensing services in the primary health care network in Brazil and in its different regions, aiming to promote the access and rational use of medicines. METHODS: This is a cross-sectional, quantitative study with data obtained from the Pesquisa Nacional sobre Acesso, Utilização e Uso Racional de Medicamentos (PNAUM - National Survey on Access, Use and Promotion of Rational Use of Medicines), 2015. Observation visits were carried out in 1,175 dispensing units, and interviews were held with 1,139 professionals responsible for the dispensation of medicines in the dispensing units and 495 municipal coordinators of pharmaceutical services...
November 13, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/29160454/pharmaceutical-care-in-brazil-s-primary-health-care
#6
Patricia Sodré Araújo, Ediná Alves Costa, Augusto Afonso Guerra, Francisco de Assis Acurcio, Ione Aquemi Guibu, Juliana Álvares, Karen Sarmento Costa, Margô Gomes de Oliveira Karnikowski, Orlando Mario Soeiro, Silvana Nair Leite
OBJECTIVE: To characterize the activities of clinical nature developed by pharmacists in basic health units and their participation in educational activities aiming at health promotion. METHODS: This article is part of the Pesquisa Nacional sobre Acesso, Utilização e Promoção do Uso Racional de Medicamentos - Serviços, 2015 (PNAUM - National Survey on Access, Use and Promotion of Rational Use of Medicines - Services, 2015), a cross-sectional and exploratory study, of evaluative nature, consisting of a survey of information in a representative sample of cities, stratified by the Brazilian regions that constitute domains of study, and a subsample of primary health care services...
November 13, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/29160450/characterization-of-the-selection-of-medicines-for-the-brazilian-primary-health-care
#7
Margô Gomes de Oliveira Karnikowski, Dayani Galato, Micheline Marie Milward de Azevedo Meiners, Emília Vitória da Silva, Letícia Farias Gerlack, Ângelo José Gonçalves Bós, Silvana Nair Leite, Juliana Álvares, Ione Aquemi Guibu, Orlando Mario Soeiro, Karen Sarmento Costa, Ediná Alves Costa, Augusto Afonso Guerra, Francisco de Assis Acurcio
OBJECTIVE: To characterize the process of selection of medicines for primary health care in the Brazilian regions. METHODS: This article is part of the Pesquisa Nacional sobre Acesso, Utilização e Promoção do Uso Racional de Medicamentos - Serviços, 2015 (PNAUM - National Survey on Access, Use and Promotion of Rational Use of Medicines - Services, 2015), a cross-sectional study that consisted of an information gathering in a sample of cities in the five regions of Brazil...
November 13, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/29159886/radiomics-in-lung-cancer-its-time-is-here
#8
Mannudeep Kalra, Ge Wang, Colin G Orton
Of the 8.8 million deaths from cancer in 2015, per the World Health Organization, lung cancer was the most common cause of death (1.69 million). With the introduction of low-dose CT for lung cancer screening and emergence of precision medicine for often-fatal lung cancer, there is a need for deep access to critical information, i.e. radiomics, not possible with conventional subjective interpretation of CT images. Quantitative image analyses for radiomics have been applied in lung cancers to determine their spatial complexity, genomic composition, viability or aggressiveness, and responses to targeted therapies...
November 21, 2017: Medical Physics
https://www.readbyqxmd.com/read/29159853/the-use-of-cell-conditioned-medium-for-musculoskeletal-tissue-regeneration
#9
REVIEW
Francesca Veronesi, Veronica Borsari, Maria Sartori, Monia Orciani, Monica Mattioli-Belmonte Cima, Milena Fini
Tissue regenerative medicine combines the use of cells, scaffolds and molecules to repair damaged tissues. Different cell types are employed for musculoskeletal diseases, both differentiated and mesenchymal stromal cells (MSCs). In recent years, the hypothesis that cell-based therapy is guided principally by cell-secreted factors has become increasingly popular. The aim of the present literature review was to evaluate preclinical and clinical studies that used conditioned medium (CM), rich in cell-factors, for musculoskeletal regeneration with a cell-free approach...
November 20, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29159852/orbital-invasive-squamous-cell-carcinoma-with-adnexal-involvement-clinically-mimicking-feline-restrictive-orbital-myofibroblastic-sarcoma-19-cases-1990-2016
#10
Kathryn A Diehl, Silvia G Pryor, Leandro Bc Teixeira
OBJECTIVE: To describe the clinical presentations of patients diagnosed with ocular adnexal or orbital squamous cell carcinoma (SCC), which possess features similar to feline restrictive orbital myofibroblastic sarcoma (FROMS). PROCEDURES: A retrospective review of adnexal and/or orbital SCC was performed. Cases were collected from the University of Georgia College of Veterinary Medicine and the Comparative Ocular Pathology Laboratory of Wisconsin (COPLOW) (1990-2016)...
November 21, 2017: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/29159842/struggle-and-failure-on-clinical-placement-a-critical-narrative-review
#11
REVIEW
Rachel Davenport, Sally Hewat, Alison Ferguson, Sue McAllister, Michelle Lincoln
BACKGROUND: Clinical placements are crucial to the development of skills and competencies in speech-language pathology (SLP) education and, more generally, a requirement of all health professional training programmes. Literature from medical education provides a context for understanding how the environment can be vital to all students' learning. Given the increasing costs of education and demands on health services, students who struggle or fail on clinical placement place an additional burden on educators...
November 21, 2017: International Journal of Language & Communication Disorders
https://www.readbyqxmd.com/read/29159788/the-fight-against-tuberculosis-in-the-mid-nineteenth-century-the-pivotal-contribution-of-edoardo-maragliano-1849-1940
#12
Mariano Martini, Ilaria Barberis, Nicola Luigi Bragazzi, Filippo Paluan
The second half of the nineteenth century saw the development of new medical "specialties", which, like the idea of constitutional disease, had a profound influence on medical practice. Against this lively "backdrop", Edoardo Maragliano played a central role in medicine's "renaissance" in Italy. Having graduated in medicine in 1870 at the University of Naples, he worked as an assistant in the University Medical Clinic. After beginning his academic career as professor of pathology at the Faculty of Medicine in Genoa in 1877, he became full professor of internal medicine in 1881...
November 21, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29159602/competitive-advantage-of-mba-for-physician-executives-a-systematic-literature-review
#13
REVIEW
Anthony D Turner, Stanislaw P Stawicki, Weidun Alan Guo
In response to systemic challenges facing the US healthcare system, many medical students, residents and practicing physicians are pursuing a Master in Business Administration (MBA) degree. The value of such proposition remains poorly defined. The aim of this review is to analyze current literature pertaining to the added value of MBA training for physician executives (PEs). We hypothesized that physicians who supplement their clinical expertise with business education gain a significant competitive advantage...
November 20, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29159419/implementation-of-clinical-quality-management-for-rehabilitation-in-malaysia
#14
Julia Patrick Engkasan, Gerold Stucki, Sadeeq Ali, Yusniza Mohd Yusof, Hafez Hussain, Lydia Abdul Latif
In February 2017, the World Health Organization (WHO) launched its historic "Rehabilitation 2030: A Call for Action". Scaling up rehabilitation in health systems requires concerted action across all 6 components of WHO's Health Systems Framework. For rehabilitation, information about functioning is essential, as it is required for effective rehabilitation at all levels of the health system. What is missing is a countrywide demonstration project involving the implementation of a clinical quality management system for the continuous improvement of rehabilitation, both at the level of clinical care for individual patients and at the level of rehabilitation service provision...
November 16, 2017: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/29159177/effectiveness-of-chinese-herbal-medicine-combined-with-antibiotics-for-extensively-drug-resistant-enterobacteria-and-nonfermentative-bacteria-infection-real-life-experience-in-a-retrospective-cohort
#15
Yangping Cai, Qing Zhang, Yuefeng Fu, Li Li, Ning Zhao, Aiping Lu, Qingquan Liu, Miao Jiang
Chinese herbal medicines (CHMs) have been successfully used in the treatment of infectious diseases, yet the effectiveness of CHMs for extensively drug-resistant enterobacteria (XDRE) infection remains unclear. Herein we developed a retrospective multicenter study including 766 patients with XDRE and nonfermentative bacteria (NFB) infection to investigate the effectiveness of CHMs combined with antibiotics in the treatment of XDRE infections in clinical daily practice in a cohort of patients and compared the regular antibiotics monotherapy...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29159025/comparison-of-the-inhibition-potentials-of-icotinib-and-erlotinib-against-human-udp-glucuronosyltransferase-1a1
#16
Xuewei Cheng, Xia Lv, Hengyan Qu, Dandan Li, Mengmeng Hu, Wenzhi Guo, Guangbo Ge, Ruihua Dong
UDP-glucuronosyltransferase 1A1 (UGT1A1) plays a key role in detoxification of many potentially harmful compounds and drugs. UGT1A1 inhibition may bring risks of drug-drug interactions (DDIs), hyperbilirubinemia and drug-induced liver injury. This study aimed to investigate and compare the inhibitory effects of icotinib and erlotinib against UGT1A1, as well as to evaluate their potential DDI risks via UGT1A1 inhibition. The results demonstrated that both icotinib and erlotinib are UGT1A1 inhibitors, but the inhibitory effect of icotinib on UGT1A1 is weaker than that of erlotinib...
November 2017: Acta Pharmaceutica Sinica. B
https://www.readbyqxmd.com/read/29159022/chinese-herbal-medicine-compound-yi-zhi-hao-pellet-inhibits-replication-of-influenza-virus-infection-through-activation-of-heme-oxygenase-1
#17
Jinqiu Yin, Linlin Ma, Huiqiang Wang, Haiyan Yan, Jin Hu, Wen Jiang, Yuhuan Li
As a leading cause of respiratory disease, influenza A virus (IAV) presents a pandemic threat in annual seasonal outbreaks. Given the limitation of existing anti-influenza therapies, there remains to be a requirement for new drugs. Compound Yi-Zhi-Hao pellet (CYZH) is a famous traditional Chinese medicine (TCM) used in the clinic, whose formula has been recorded in Complication of National Standard for Traditional Chinese Medicine to treat common cold. In this study, we found that CYZH exhibited a broad-spectrum anti-influenza activity and inhibited the expression of viral RNA and proteins in vitro...
November 2017: Acta Pharmaceutica Sinica. B
https://www.readbyqxmd.com/read/29158740/xeno-free-strategies-for-safe-human-mesenchymal-stem-stromal-cell-expansion-supplements-and-coatings
#18
REVIEW
M Cimino, R M Gonçalves, C C Barrias, M C L Martins
Human mesenchymal stem/stromal cells (hMSCs) have generated great interest in regenerative medicine mainly due to their multidifferentiation potential and immunomodulatory role. Although hMSC can be obtained from different tissues, the number of available cells is always low for clinical applications, thus requiring in vitro expansion. Most of the current protocols for hMSC expansion make use of fetal bovine serum (FBS) as a nutrient-rich supplement. However, regulatory guidelines encourage novel xeno-free alternatives to define safer and standardized protocols for hMSC expansion that preserve their intrinsic therapeutic potential...
2017: Stem Cells International
https://www.readbyqxmd.com/read/29158647/performance-of-physiology-scoring-systems-in-prediction-of-in-hospital-mortality-of-traumatic-children-a-prospective-observational-study
#19
Babak Nakhjavan-Shahraki, Mahmoud Yousefifard, Gholamreza Faridaalaee, Kavous Shahsavari, Alireza Oraii, Mohammad Javad Hajighanbari, Parviz Karimi, Fatemeh Mahdizadeh, Samaneh Abiri, Mostafa Hosseini
Background: This study is designed to compare the value of four physiologic scoring systems of rapid acute physiology score (RAPS), rapid emergency medicine score (REMS), Worthing physiology scoring system (WPSS) and revised trauma score (RTS) in predicting the in-hospital mortality of traumatic children brought to the emergency department. Method: We used the data gathered from six healthcare centers across Iran between the April-October 2016. Included patients were all children with trauma...
November 2017: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/29158373/revisiting-expectations-in-an-era-of-precision-oncology
#20
Emily J Marchiano, Andrew C Birkeland, Paul L Swiecicki, Kayte Spector-Bagdady, Andrew G Shuman
As we enter an era of precision medicine and targeted therapies in the treatment of metastatic cancer, we face new challenges for patients and providers alike as we establish clear guidelines, regulations, and strategies for implementation. At the crux of this challenge is the fact that patients with advanced cancer may have disproportionate expectations of personal benefit when participating in clinical trials designed to generate generalizable knowledge. Patient and physician goals of treatment may not align, and reconciliation of their disparate perceptions must be addressed...
November 20, 2017: Oncologist
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