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https://www.readbyqxmd.com/read/29346720/nanoscale-control-of-molecular-self-assembly-induced-by-plasmonic-hot-electron-dynamics
#1
Sabrina Simoncelli, Yi Li, Emiliano Cortes, Stefan A Maier
Self-assembly processes allow designing and creating complex nanostructures using molecules as building blocks and surfaces as scaffolds. This autonomous driven construction is possible due to a complex thermodynamic balance of molecule-surface interactions. As such, nanoscale guidance and control over this process is hard to achieve. Here we use the highly localized light-to-chemical-energy conversion of plasmonic materials to spatially cleave Au-S bonds on pre-determined locations within a single nanoparticle, enabling a high degree of control over this archetypal system for molecular self-assembly...
January 18, 2018: ACS Nano
https://www.readbyqxmd.com/read/29346521/the-intracellular-and-intercellular-cross-talk-during-subsidiary-cell-formation-in-zea-mays-existing-and-novel-components-orchestrating-cell-polarization-and-asymmetric-division
#2
P Apostolakos, P Livanos, E Giannoutsou, E Panteris, B Galatis
Background: Formation of stomatal complexes in Poaceae is the outcome of three asymmetric and one symmetric cell division occurring in particular leaf protodermal cells. In this definite sequence of cell division events, the generation of subsidiary cells is of particular importance and constitutes an attractive model for studying local intercellular stimulation. In brief, an induction stimulus emitted by the guard cell mother cells (GMCs) triggers a series of polarization events in their laterally adjacent protodermal cells...
January 15, 2018: Annals of Botany
https://www.readbyqxmd.com/read/29346414/reliability-of-plasma-polar-metabolite-concentrations-in-a-large-scale-cohort-study-using-capillary-electrophoresis-mass-spectrometry
#3
Sei Harada, Akiyoshi Hirayama, Queenie Chan, Ayako Kurihara, Kota Fukai, Miho Iida, Suzuka Kato, Daisuke Sugiyama, Kazuyo Kuwabara, Ayano Takeuchi, Miki Akiyama, Tomonori Okamura, Timothy M D Ebbels, Paul Elliott, Masaru Tomita, Asako Sato, Chizuru Suzuki, Masahiro Sugimoto, Tomoyoshi Soga, Toru Takebayashi
BACKGROUND: Cohort studies with metabolomics data are becoming more widespread, however, large-scale studies involving 10,000s of participants are still limited, especially in Asian populations. Therefore, we started the Tsuruoka Metabolomics Cohort Study enrolling 11,002 community-dwelling adults in Japan, and using capillary electrophoresis-mass spectrometry (CE-MS) and liquid chromatography-mass spectrometry. The CE-MS method is highly amenable to absolute quantification of polar metabolites, however, its reliability for large-scale measurement is unclear...
2018: PloS One
https://www.readbyqxmd.com/read/29346379/a-putative-lateral-flagella-of-the-cystic-fibrosis-pathogen-burkholderia-dolosa-regulates-swimming-motility-and-host-cytokine-production
#4
Damien Roux, Matthew Schaefers, Bradley S Clark, Molly Weatherholt, Diane Renaud, David Scott, John J LiPuma, Gregory Priebe, Craig Gerard, Deborah R Yoder-Himes
Burkholderia dolosa caused an outbreak in the cystic fibrosis clinic at Boston Children's Hospital and was associated with high mortality in these patients. This species is part of a larger complex of opportunistic pathogens known as the Burkholderia cepacia complex (Bcc). Compared to other species in the Bcc, B. dolosa is highly transmissible; thus understanding its virulence mechanisms is important for preventing future outbreaks. The genome of one of the outbreak strains, AU0158, revealed a homolog of the lafA gene encoding a putative lateral flagellin, which, in other non-Bcc species, is used for movement on solid surfaces, attachment to host cells, or movement inside host cells...
2018: PloS One
https://www.readbyqxmd.com/read/29346350/epithelial-mesenchymal-transition-in-crohn-s-disease
#5
REVIEW
H Jiang, J Shen, Z Ran
Crohn's disease (CD) is often accompanied by the complications of intestinal strictures and fistulas. These complications remain obstacles in CD treatment. In recent years, the importance of epithelial-mesenchymal transition in the pathogenesis of CD-associated fistulas and intestinal fibrosis has become apparent. Epithelial-mesenchymal transition refers to a dynamic change, wherein epithelial cells lose their polarity and adherence and acquire migratory function and fibroblast features. During formation of CD-associated fistulas, intestinal epithelial cells dislocate from the basement membrane and migrate to the lining of the fistula tracts, where they convert into transitional cells as a compensatory response under the insufficient wound healing condition...
December 20, 2017: Mucosal Immunology
https://www.readbyqxmd.com/read/29346102/impedance-measures-during-in-vitro-cochlear-implantation-predict-array-positioning
#6
Christopher Kenneth Giardina, Elliot Samuel Krause, Kanthaiah Koka, Douglas Carl Fitzpatrick
OBJECTIVE: Improper electrode placement during cochlear implant (CI) insertion can adversely affect speech perception outcomes. However, the intraoperative methods to determine positioning are limited. Because measures of electrode impedance can be made quickly, the goal of this study was to assess the relationship between CI impedance and proximity to adjacent structures. METHODS: An Advanced Bionics CI array was inserted into a clear, plastic cochlea one electrode contact at a time in a saline bath (nine trials)...
February 2018: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/29346093/multipolarization-through-wall-radar-imaging-using-low-rank-and-jointly-sparse-representations
#7
Van Ha Tang, Abdesselam Bouzerdoum, Son Lam Phung
Compressed sensing techniques have been applied to through-the-wall radar imaging (TWRI) and multipolarization TWRI for fast data acquisition and enhanced target localization. The studies so far in this area have either assumed effective wall clutter removal prior to image formation or performed signal estimation, wall clutter mitigation, and image formation independently. This paper proposes a low-rank and sparse imaging model for jointly addressing the problem of wall clutter mitigation and image formation in multichannel TWRI...
April 2018: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/29345950/confined-electroconvective-vortices-at-structured-ion-exchange-membranes
#8
Joeri de Valença, Morten Jõgi, R Martijn Wagterveld, Elif Karatay, Jeffery A Wood, Rob G H Lammertink
In this paper, we investigate electroconvective ion transport at cation exchange membranes with different geometry square-wave structures (line undulations) experimentally and numerically. Electroconvective micro-vortices are induced by strong concentration polarization once a threshold potential difference is applied. The applied potential required to start and sustain electroconvection is strongly affected by the geometry of the membrane. A reduction in the resistance of approximately 50% can be obtained when the structure size is similar to the mixing layer thickness, resulting in confined vortices with less lateral motion compared to the case of flat membranes...
January 18, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29345933/large-scale-functional-group-symmetry-adapted-perturbation-theory-on-graphical-processing-units
#9
Robert M Parrish, Keiran C Thompson, Todd J Martínez
Symmetry-adapted perturbation theory (SAPT) is a valuable method for analyzing intermolecular interactions. The functional group SAPT partition (F-SAPT) has been introduced to provide additional insight into the origins of noncovalent interactions. Until now, SAPT analysis has been too costly for large ligand-protein complexes where it could provide key insights for chemical modifications that might improve ligand binding. In this paper, we present a large-scale implementation of F-SAPT which is especially efficient when one of the interacting monomers is significantly larger than the other, as is usually the case for drug-protein interactions...
January 18, 2018: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/29345913/non-centrosymmetric-rbnamgp2o7-with-unprecedented-thermo-induced-enhancement-of-second-harmonic-generation
#10
Sangen Zhao, Xiaoyan Yang, Yi Yang, Xiaojun Kuang, Fengqi Lu, Pai Shan, Zhihua Sun, Zheshuai Lin, Maochun Hong, Junhua Luo
It is of great difficulty to obtain deep-UV transparent materials with enhanced second harmonic generation (SHG), mainly limited by the theoretically poor transparency of these materials in the deep-UV spectral region. Here we report a new non-centrosymmetric, deep-UV transparent phosphate RbNaMgP2O7, which undergoes a thermo-induced reversible phase transition (at a high temperature of 723 K) and correspondingly an evident SHG enhancement up to ~1.5 times. The phase transition is aroused by the twist of [P2O7]4- dimers with deviation from the P-O-P equilibrium positions...
January 18, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29345905/chelate-assisted-ring-closing-metathesis-a-strategy-for-accelerated-macrocyclization-at-ambient-temperatures
#11
Carolyn S Higman, Daniel Luis do Nascimento, Benjamin J Ireland, Stephan Audörsch, Gwendolyn A Bailey, Robert McDonald, Deryn Elizabeth Fogg
Ring-closing metathesis (RCM) offers versatile catalytic routes to macrocycles, with applications ranging from perfumery to production of antiviral drugs. Unwanted oligomerization, however, is a long-standing challenge. Oligomers can be converted into the cyclic targets by catalysts that are sufficiently reactive to promote backbiting (e.g. Ru complexes of N-heterocyclic carbenes; NHCs), but catalyst decomposition limits yields and selectivity. Incorporation of a hemilabile o-dianiline (ODA) chelate into new catalysts of the form RuCl2(NHC)(ODA)(=CHPh) accelerates macrocyclization, particularly for dienes bearing polar sites capable of H-bonding: it may also inhibit catalyst decomposition during metathesis...
January 18, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29345709/chain-conformation-of-poly-acrylic-acid-graft-poly-ethylene-oxide-graft-dodecyl-in-solution-an-anomalous-counter-ions-condensation
#12
Xinlu Zhou, Kongshuang Zhao
A dielectric spectroscopy study on a polyelectrolyte in aqueous solutions, which contains hydrophobic groups in part of the side chains poly(acrylic acid)-graft-poly(ethylene oxide)-graft-dodecyl (PAA-g-PEO-g-dodecyl) is reported. A refined double layer polarization model was proposed to analyze the double dielectric relaxations in the dielectric spectra. Various electrical and structural parameters of the copolymers were obtained. Besides the crossover concentration, another turning point around 4 mg mL-1 was identified through the analysis of all the dielectrical parameters including dielectric increment, relaxation time and correlation length...
January 18, 2018: Soft Matter
https://www.readbyqxmd.com/read/29345390/wnt-%C3%AE-catenin-pathway-promotes-early-engraftment-of-fetal-hematopoietic-stem-progenitor-cells
#13
Edward O Kwarteng, Roxann Hétu-Arbour, Krista M Heinonen
The switch from fetal to adult hematopoietic stem/progenitor cells (HSPCs) is associated with profound changes in several genetic programs. Although HSPC ageing corresponds to alterations in Wnt signaling, relatively little is known about the relative roles of different Wnt signaling pathways in HSPC ontogeny. We hypothesized that proliferating fetal HSPCs would be more dependent on canonical β-catenin-dependent Wnt signaling when compared to quiescent adult bone marrow HSPCs. We have compared here Wnt signaling activities in murine fetal and adult HSPCs and demonstrate a shift from Wnt/β-catenin-dependent signaling in fetal liver HSPCs to more predominantly noncanonical Wnt/polarity signaling in adult HSPCs...
January 17, 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29345377/flexoelectricity-in-bones
#14
Fabian Vasquez-Sancho, Amir Abdollahi, Dragan Damjanovic, Gustau Catalan
Bones generate electricity under pressure, and this electromechanical behavior is thought to be essential for bone's self-repair and remodeling properties. The origin of this response is attributed to the piezoelectricity of collagen, which is the main structural protein of bones. In theory, however, any material can also generate voltages in response to strain gradients, thanks to the property known as flexoelectricity. In this work, the flexoelectricity of bone and pure bone mineral (hydroxyapatite) are measured and found to be of the same order of magnitude; the quantitative similarity suggests that hydroxyapatite flexoelectricity is the main source of bending-induced polarization in cortical bone...
January 18, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29345372/truncation-of-neurokinin-1-receptor-negative-regulation-of-substance-p-signaling
#15
REVIEW
Sergei Spitsin, Vasiliki Pappa, Steven D Douglas
Substance P (SP) is a tachykinin peptide, which triggers intracellular signaling in the nervous and immune systems, as well as, other local and systemic events. The interaction between SP and its receptor, neurokinin-1 receptor (NK1R), results in major downstream cellular actions, which include changes in calcium fluxes, ERK, and p21-activated kinase phosphorylation and NFκB activation. Two naturally occurring variants of the NK1R, the full-length, 407 aa receptor (NK1R-F) and the truncated, 311 aa isoform (NK1R-T), mediate the actions of SP...
January 10, 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29345368/therapeutic-effect-of-lipoxin-a4-%C3%A2-in-malaria-induced-acute-lung-injury
#16
Tatiana A Pádua, Natalia D Torres, André L P Candéa, Maria Fernanda Souza Costa, Johnatas D Silva, João Luiz Silva-Filho, Fabio T M Costa, Patricia R M Rocco, Mariana C Souza, Maria G Henriques
Acute lung injury (ALI) models are characterized by neutrophil accumulation, tissue damage, alteration of the alveolar capillary membrane, and physiological dysfunction. Lipoxin A4  (LXA4 ) is an anti-inflammatory eicosanoid that was demonstrated to attenuate lipopolysaccharide-induced ALI. Experimental models of severe malaria can be associated with lung injury. However, to date, a putative effect of LXA4  on malaria (M)-induced ALI has not been addressed. In this study, we evaluated whether LXA4 exerts an effect on M-ALI...
January 3, 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29345364/the-n-terminal-peptide-moiety-of-the-mycobacterium-tuberculosis-19-kda-lipoprotein-harbors-rp105-agonistic-properties
#17
Thomas E Schultz, Karl-Heinz Wiesmüller, Megan Lucas, Karen M Dobos, Alan G Baxter, Antje Blumenthal
Radioprotective 105 kDa (RP105, CD180) is a member of the Toll-like receptor (TLR) family that interacts with TLR2 and facilitates recognition of mature lipoproteins expressed by Mycobacterium tuberculosis and Mycobacterium bovis BCG. In this study, we used synthetic lipopeptide analogs of the M. tuberculosis 19 kDa lipoprotein to define structural characteristics that promote RP105-mediated host cell responses. A tripalmitoylated lipopeptide composed of the first 16 N-terminal amino acids of the M. tuberculosis 19 kDa lipoprotein induced RP105-dependent TNF and IL-6 production by macrophages...
January 9, 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29345359/pdz-proteins-are-expressed-and-regulated-in-antigen-presenting-cells-and-are-targets-of-influenza-a-virus
#18
Dante Barreda, Marisa Sánchez-Galindo, Jessica López-Flores, Karen E Nava-Castro, Karen Bobadilla, Alfonso Salgado-Aguayo, Teresa Santos-Mendoza
In this work, we identified the expression, regulation, and viral targeting of Scribble and Dlg1 in antigen-presenting cells. Scribble and Dlg1 belong to the family of PDZ (postsynaptic density (PSD95), disc large (Dlg), and zonula occludens (ZO-1)) proteins involved in cell polarity. The relevance of PDZ proteins in cellular functions is reinforced by the fact that many viruses interfere with host PDZ-dependent interactions affecting cellular mechanisms thus favoring viral replication. The functions of Scribble and Dlg have been widely studied in polarized cells such as epithelial and neuron cells...
December 27, 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29345336/%C3%AE-%C3%AE-cells-and-tumor-microenvironment-a-helpful-or-a-dangerous-liason
#19
REVIEW
Elena Lo Presti, Roberto Di Mitri, Gabriele Pizzolato, Filippo Mocciaro, Francesco Dieli, Serena Meraviglia
γδ T cells are a subset of T lymphocytes that have been implicated in immunosurveillance against infections and tumors. γδ T cells are endowed with antitumor activities, and hence several γδ T cell-based small-scale clinical trials have been conducted either by in vivo activation by intravenous administration of aminobiphosphonates or by adoptive transfer of in vitro expanded γδ T cells. Although both these strategies have yielded promising results, there are a number of limitations associated with each of them which, if overcome may help to further improve efficacy...
December 14, 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29345059/microrna-networks-associated-with-active-systemic-juvenile-idiopathic-arthritis-regulate-cd163-expression-and-anti-inflammatory-functions-in-macrophages-through-two-distinct-mechanisms
#20
Thuy Do, Rachel Tan, Mark Bennett, Mario Medvedovic, Alexei A Grom, Nan Shen, Sherry Thornton, Grant S Schulert
Systemic juvenile idiopathic arthritis (SJIA) is a severe childhood arthropathy with features of autoinflammation. Monocytes and macrophages in SJIA have a complex phenotype with both pro- and anti-inflammatory properties that combine features of several well characterized in vitro conditions used to activate macrophages. An important anti-inflammatory phenotype is expression of CD163, a scavenger receptor that sequesters toxic pro-inflammatory complexes that is highly expressed in both active SJIA and macrophage activation syndrome (MAS)...
January 2018: Journal of Leukocyte Biology
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