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https://www.readbyqxmd.com/read/28215054/semiparametric-modeling-and-analysis-of-longitudinal-method-comparison-data
#1
Lasitha N Rathnayake, Pankaj K Choudhary
Studies comparing two or more methods of measuring a continuous variable are routinely conducted in biomedical disciplines with the primary goal of measuring agreement between the methods. Often, the data are collected by following a cohort of subjects over a period of time. This gives rise to longitudinal method comparison data where there is one observation trajectory for each method on every subject. It is not required that observations from all methods be available at each observation time. The multiple trajectories on the same subjects are dependent...
February 19, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/28215051/-pro-renin-receptor-atp6ap2-depletion-arrests-as4-1-cells-in-the-g0-g1-phase-thereby-increasing-formation-of-primary-cilia
#2
Heike Wanka, Philipp Lutze, Doreen Staar, Barbara Peters, Anica Morch, Lukas Vogel, Ravi Kumar Chilukoti, Georg Homuth, Jaroslaw Sczodrok, Inga Bäumgen, Jörg Peters
The (pro)renin receptor [(P)RR, ATP6AP2] is a multifunctional transmembrane protein that activates local renin-angiotensin systems, but also interacts with Wnt pathways and vacuolar H(+) -ATPase (V-ATPase) during organogenesis. The aim of this study was to characterize the role of ATP6AP2 in the cell cycle in more detail. ATP6AP2 down-regulation by siRNA in renal As4.1 cells resulted in a reduction in the rate of proliferation and a G0/G1 phase cell cycle arrest. We identified a number of novel target genes downstream of ATP6AP2 knock-down that were related to the primary cilium (Bbs-1, Bbs-3, Bbs-7, Rabl5, Ttc26, Mks-11, Mks-5, Mks-2, Tctn2, Nme7) and the cell cycle (Pierce1, Clock, Ppif)...
February 19, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28215047/pharyngeal-swallowing-pressures-in-the-base-of-tongue-and-hypopharynx-regions-identified-with-three-dimensional-manometry
#3
Sarah P Rosen, Corinne A Jones, Timothy M McCulloch
OBJECTIVES: This study aims to use three-dimensional (3D) high-resolution manometry to identify circumferential pressure patterns generated within the asymmetrical base-of-tongue and hypopharynx regions of the pharynx during deglutition. STUDY DESIGN: Case series. METHODS: Radial pressures in the regions of interest were evaluated during swallowing events in 12 healthy subjects using 3D high-resolution manometry. RESULTS: Repeated measures analysis of variance revealed asymmetrical pharyngeal clearance pressures in the base-of-tongue and hypopharynx regions during swallowing...
February 19, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28215044/developing-caring-conversations-in-care-homes-an-appreciative-inquiry
#4
Belinda Dewar, Tamsin MacBride
Relationship-centred practice is key to delivering quality care in care homes. Evidence is strong about the centrality of human interaction in developing relationships that promote dignity and compassion. The Caring Conversations framework is a framework for delivering compassionate care based on human interactions that was developed in the acute healthcare setting. The key attributes are: be courageous, connect emotionally, be curious, consider other perspectives, collaborate, compromise and celebrate. This paper reports on a study to explore its relevance to the care home setting and the development of an educational intervention, based on the framework, to enhance development of human interaction...
February 19, 2017: Health & Social Care in the Community
https://www.readbyqxmd.com/read/28215023/hpa-axis-activation-as-a-key-moderator-of-childhood-trauma-exposure-and-adolescent-mental-health
#5
Kate R Kuhlman, Elisa G Geiss, Ivan Vargas, Nestor Lopez-Duran
Individual differences in a child's sensitivity to stress may influence whether youth exposed to trauma develop symptoms of psychopathology. We examined the interaction between HPA-axis reactivity to an acute stressor and exposure to different types of childhood trauma as predictors of mental health symptoms in a sample of youth. Youth (n = 121, ages 9-16; 47% female) completed a standardized stress task, including 5 post-stress salivary cortisol samples. Parents also completed the Child Behavior Checklist as a measure of child internalizing and externalizing symptoms in the past month, and completed the Early Trauma Inventory (ETI) as a measure of their child's trauma exposure...
February 18, 2017: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/28215012/threatened-species-to-super-abundance-the-unexpected-international-implications-of-successful-goose-conservation
#6
Anthony D Fox, Jesper Madsen
Wild geese wintering in western Europe were declining by the 1930s probably due to loss of natural habitat and over exploitation through hunting, although the causes will never be known. Refuge provision and hunting restrictions from the 1950s enabled numbers to recover. Improved monitoring systems enabled the description of progressive increases and extensions of wintering range since that time, especially amongst those goose populations that increasingly exploited agricultural landscapes. This introductory article sets the scene for the special issue on the increasing interactions and conflicts created by recent increases in the range and abundance of wild geese throughout the northern hemisphere, especially with regard to agricultural damage, but including issues associated with air flight safety, human and animal health, ecosystem effects and conflicts with other biodiversity objectives...
March 2017: Ambio
https://www.readbyqxmd.com/read/28214990/interactions-between-mesenchymal-stem-cells-and-the-immune-system
#7
REVIEW
Na Li, Jinlian Hua
In addition to being multi-potent, mesenchymal stem cells (MSCs) possess immunomodulatory functions that have been investigated as potential treatments in various immune disorders. MSCs can robustly interact with cells of the innate and adaptive immune systems, either through direct cell-cell contact or through their secretome. In this review, we discuss current findings regarding the interplay between MSCs and different immune cell subsets. We also draw attention to the mechanisms involved.
February 18, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/28214987/severe-convulsions-and-dysmyelination-in-both-jimpy-and-cx32-47-mice-may-associate-astrocytic-l-channel-function-with-myelination-and-oligodendrocytic-connexins-with-internodal-kv-channels
#8
Y H Gerald Chaban, Ye Chen, Elna Hertz, Leif Hertz
The Jimpy mouse illustrates the importance of interactions between astrocytes and oligodendrocytes. It has a mutation in Plp coding for proteolipid protein and DM20. Its behavior is normal at birth but from the age of ~2 weeks it shows severe convulsions associated with oligodendrocyte/myelination deficits and early death. A normally occurring increase in oxygen consumption by highly elevated K(+) concentrations is absent in Jimpy brain slices and cultured astrocytes, reflecting that Plp at early embryonic stages affects common precursors as also shown by the ability of conditioned medium from normal astrocytes to counteract histological abnormalities...
February 18, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28214974/interaction-of-scots-pine-defensin-with-model-membrane-by-coarse-grained-molecular-dynamics
#9
Elena Ermakova, Yuriy Zuev
Plant defensins are a part of the innate immune system of plants that acts against a broad range of pathogens. Many plant defensins, including pine defensins, show strong antifungal activity that is associated with their ability to penetrate into the fungal cell membrane. However, the exact molecular mechanism of their action remains poorly defined. To obtain insight into the mechanism of protein-membrane interaction, we applied a coarse-grained molecular dynamics simulation to study the interaction of pine defensin with two model membranes: the first consisted of zwitterion-neutral POPC molecules and the second was composed of combined anionic POPG and POPC...
February 18, 2017: Journal of Membrane Biology
https://www.readbyqxmd.com/read/28214944/the-vascular-plants-open-system-of-growth
#10
REVIEW
Alice Basile, Marco Fambrini, Claudio Pugliesi
What is fascinating in plants (true also in sessile animals such as corals and hydroids) is definitely their open and indeterminate growth, as a result of meristematic activity. Plants as well as animals are characterized by a multicellular organization, with which they share a common set of genes inherited from a common eukaryotic ancestor; nevertheless, circa 1.5 billion years of evolutionary history made the two kingdoms very different in their own developmental biology. Flowering plants, also known as angiosperms, arose during the Cretaceous Period (145-65 million years ago), and up to date, they count around 235,000 species, representing the largest and most diverse group within the plant kingdom...
February 18, 2017: Development Genes and Evolution
https://www.readbyqxmd.com/read/28214936/an-assessment-of-strontium-sorption-onto-bentonite-buffer-material-in-waste-repository
#11
Pankaj Pathak
In the present study, changes occurring in sorption characteristics of a representative bentonite (WIn-BT) exposed to SrCl2 (0.001-0.1 M) under the pH range of 1-13 were investigated. Such interaction revealed a significant variation in surface charge density and binding energy of ions with respect to bentonite, and alteration in their physicochemical properties viz., specific surface area, cation exchange capacity, thermal and mechanical behaviour were observed. The distribution coefficients (k d) calculated for sorption onto virgin (UCBT) and contaminated bentonite (CBT) indicated a greater influence of mineralogical changes occurred with variance of pH and strontium concentration...
February 18, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28214932/theoretical-and-experimental-study-of-polycyclic-aromatic-compounds-as-%C3%AE-tubulin-inhibitors
#12
Fabian E Olazarán, Carlos A García-Pérez, Debasish Bandyopadhyay, Isaias Balderas-Rentería, Angel D Reyes-Figueroa, Lars Henschke, Gildardo Rivera
In this work, through a docking analysis of compounds from the ZINC chemical library on human β-tubulin using high performance computer cluster, we report new polycyclic aromatic compounds that bind with high energy on the colchicine binding site of β-tubulin, suggesting three new key amino acids. However, molecular dynamic analysis showed low stability in the interaction between ligand and receptor. Results were confirmed experimentally in in vitro and in vivo models that suggest that molecular dynamics simulation is the best option to find new potential β-tubulin inhibitors...
March 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/28214931/subtle-nets-finder-finely-tuned-interaction-networks-in-dna-rna-protein-complexes
#13
Alexander A Kantardjiev
Graphical Abstract Subtle.Nets.Finder is a workflow of algorithms for identification of subtly interacting groups in DNA/RNA/protein complexes. It is founded on detailed and sophisticated evaluation of the self-consistency in the cooperative network of residue interactions via a combination of advanced calculations (fast multipole method and statistical mechanics) supplemented with graph-theoretical procedures.
March 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/28214904/rs10719-polymorphism-located-within-drosha-3-untranslated-region-is-responsible-for-development-of-primary-hypertension-by-disrupting-binding-with-microrna-27b
#14
Yabing Zhang, Ai-Lin Cao, Chun Dong
BACKGROUND MiR-27b is reportedly involved with many diseases (e.g., gastric cancer) by acting on different signaling pathways. In this study, we aimed at understanding the relationship between miR-27b and hypertension and its underlying molecular mechanism. MATERIAL AND METHODS Peripheral blood was collected from patients with hypertension, and statistical analysis was performed to study the association between rs10719 and risk of hypertension. Tissue samples were collected from patients with lung cancer, and the expression of miR-27b and DROSHA was determined using Western blot analysis and real-time PCR...
February 19, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28214857/epigenetic-alterations-in-cellular-immunity-new-insights-into-autoimmune-diseases
#15
Zijun Wang, Qianjin Lu, Zhihui Wang
Epigenetic modification is an additional regulator in immune responses as the genome-wide profiling somehow fails to explain the sophisticated mechanisms in autoimmune diseases. The effect of epigenetic modifications on adaptive immunity derives from their regulations to induce a permissive or negative gene expression. Epigenetic events, such as DNA methylation, histone modifications and microRNAs (miRNAs) are often found in T cell activation, differentiation and commitment which are the major parts in cellular immunity...
February 8, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28214851/lysophosphatidic-acid-promotes-epithelial-to-mesenchymal-transition-in-ovarian-cancer-cells-by-repressing-sirt1
#16
Upasana Ray, Sib Sankar Roy, Shreya Roy Chowdhury
BACKGROUND/AIMS: Epithelial-to-mesenchymal transition (EMT) plays an essential role in the transition from early to invasive phenotype, however the underlying mechanisms still remain elusive. Herein, we propose a mechanism through which the class-III deacetylase SIRT1 regulates EMT in ovarian cancer (OC) cells. METHODS: Expression analysis was performed using Q-PCR, western blot, immunofluorescence and fluorescence-IHC study. Matrigel invasion assay was used for the invasion study...
February 14, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28214848/human-birth-weight-and-reproductive-immunology-testing-for-interactions-between-maternal-and-offspring-kir-and-hla-c-genes
#17
Michelle M Clark, Olympe Chazara, Eric M Sobel, Håkon K Gjessing, Per Magnus, Ashley Moffett, Janet S Sinsheimer
BACKGROUND/AIMS: Maternal and offspring cell contact at the site of placentation presents a plausible setting for maternal-fetal genotype (MFG) interactions affecting fetal growth. We test hypotheses regarding killer cell immunoglobulin-like receptor (KIR) and HLA-C MFG effects on human birth weight by extending the quantitative MFG (QMFG) test. METHODS: Until recently, association testing for MFG interactions had limited applications. To improve the ability to test for these interactions, we developed the extended QMFG test, a linear mixed-effect model that can use multi-locus genotype data from families...
February 18, 2017: Human Heredity
https://www.readbyqxmd.com/read/28214826/emodin-increases-expression-of-insulin-like-growth-factor-binding-protein-1-through-activation-of-mek-erk-ampk%C3%AE-and-interaction-of-ppar%C3%AE-and-sp1-in-lung-cancer
#18
Qing Tang, JingJing Wu, Fang Zheng, Swei Sunny Hann, YuQing Chen
BACKGROUND: Emodin has anti-neoplastic activities on multiple tumors. However, the molecular mechanisms underlying this effect still remain to be fully understood. METHODS: Cell viability and cell cycle distribution were measured using 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assays and flow cytometry, respectively. Cell invasion and migration were examined by transwell invasion and wound healing assays. Western blot analysis was performed to examine the phosphorylation and protein expression of AMP-activated protein kinase alpha (AMPKα), extracellular signaling-regulated kinase 1/2 (ERK1/2), peroxisome proliferators-activated receptor gamma (PPARγ), insulin-like growth factor (IGF) binding protein 1 (IGFBP1) and the transcription factor Sp1...
January 26, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28214783/group-engagement-in-persons-with-dementia-the-concept-and-its-measurement
#19
Jiska Cohen-Mansfield, Tasmia Hai, Michael Comishen
Although a few papers documented benefits of group therapeutic activities for individuals with dementia, there is a dearth of studies that have investigated the effects of group activities on persons with dementia. This paper introduces a theoretical framework of studying group therapeutic recreational activity, the Comprehensive Process Model of Group Engagement, and an assessment tool, the Group Observational Measurement of Engagement (GOME). We also report the psychometric properties of this assessment. One hundred and four persons with dementia took part in ten different group activities, with each activity conducted twice at random order so that 20 activities were observed for each group of participants...
February 6, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28214748/electrochemical-monitoring-of-biointeraction-by-graphene-based-material-modified-pencil-graphite-electrode
#20
Ece Eksin, Erhan Zor, Arzum Erdem, Haluk Bingol
Recently, the low-cost effective biosensing systems based on advanced nanomaterials have received a key attention for development of novel assays for rapid and sequence-specific nucleic acid detection. The electrochemical biosensor based on reduced graphene oxide (rGO) modified disposable pencil graphite electrodes (PGEs) were developed herein for electrochemical monitoring of DNA, and also for monitoring of biointeraction occurred between anticancer drug, Daunorubicin (DNR), and DNA. First, rGO was synthesized chemically and characterized by using UV-Vis, TGA, FT-IR, Raman Spectroscopy and SEM techniques...
February 11, 2017: Biosensors & Bioelectronics
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