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James Dugan, Daniel Pollyea
In August 2017 the United States Federal Drug Administration (FDA) approved enasidenib (Idhifa, Celgene/Agios) for adults with relapsed and refractory acute myelogenous leukemia (AML) with an IDH2 mutation. Enasidenib targets cells with mutant copies of isocitrate dehydrogenase-2 (IDH2), inhibiting the oncometabolite 2-hydroxyglutarte (2-HG) formed by the mutant IDH2. Areas covered: We review the studies leading to enasidenib's approval, as well as common side effects and safety issues experienced during the clinical trials...
May 17, 2018: Expert Review of Clinical Pharmacology
Junlei Zhang, Zhen Ma
Ag-Ag3 VO4 /AgIO3 composites composed of Ag-Ag3 VO4 particles (major component) and AgIO3 nanosheets (minor component) were obtained via photoreduction of Ag3 VO4 /AgIO3 composites prepared by sequential precipitation. The optimal Ag-Ag3 VO4 /AgIO3 catalysts (in particular, the one with an AgIO3 /Ag3 VO4 mass ratio of 6.4%) were found to be more active than AgIO3 , Ag3 VO4 , and Ag-Ag3 VO4 in the photocatalytic degradation of rhodamine B (RhB), methylene blue (MB), methyl orange (MO), and tetracycline hydrochloride (TC) under visible-light irradiation...
April 3, 2018: Journal of Colloid and Interface Science
Nerantzis Kazakis, Nikolaos Kantiranis, Kyriaki Kalaitzidou, Efthimia Kaprara, Manassis Mitrakas, Robert Frei, George Vargemezis, Dimitrios Vogiatzis, Anastasios Zouboulis, Anestis Filippidis
Hexavalent chromium is one of the most toxic and carcinogenic species known and can be released into the environment from several sources. In Sarigkiol basin (N Greece) the presence of Cr(VI) in soil, sediments and groundwater may originate from both natural (ophiolitic rocks and their weathering products) and anthropogenic (dispersed fly ash produced from lignite power plants) sources. In this study, the distribution of contents and origin of environmentally available Cr(VI) in soils, sediments, regoliths and fly ash of Sarigkiol basin is presented...
April 2018: Environmental Pollution
El Hadji Seck, Mamadou Beye, Sory Ibrahima Traore, Saber Khelaifia, Caroline Michelle, Carine Couderc, Souleymane Brah, Pierre-Edouard Fournier, Didier Raoult, Fadi Bittar
Strain SIT6T was isolated from the fecal flora of a severely malnourished child as part of a broad "culturomics" study aiming to maximize the culture conditions for the in-depth exploration of the human microbiota. An analysis of the 16S rRNA gene sequence showed that strain SIT6T shared 94.1% 16S rRNA gene sequence similarity with Bacillus thermoamylovorans DKPT (NR_029151), the phylogenetically closest type species. Colonies are creamy white, circular, 4-5 mm in diameter after cultivation at 37°C for 24 hr on 5% sheep blood-enriched Colombia agar...
February 2018: MicrobiologyOpen
Esther S Kim
Enasidenib (Idhifa®) is an oral isocitrate dehydrogenase-2 (IDH2) inhibitor developed by Celgene Corporation under a global, exclusive license from Agios Pharmaceuticals. Enasidenib has been approved in the USA for the treatment of adults with relapsed or refractory acute myeloid leukaemia (AML) and an IDH2 mutation as detected by an FDA-approved test. It is at various stages of development in other countries for AML, myelodysplastic syndromes and solid tumours. This article summarizes the milestones in the development of enasidenib leading to this first global approval in the USA for the treatment of adults with relapsed or refractory IDH2-mutated AML...
October 2017: Drugs
Jonathan R Brody, Cinthya S Yabar, Mahsa Zarei, Joseph Bender, Lynn M Matrisian, Lola Rahib, Craig Heartwell, Kimberly Mason, Charles J Yeo, Stephen C Peiper, Wei Jiang, Katelyn Varieur, Subha Madhavan, Emanuel Petricoin, Danielle Fortuna, Mark Curtis, Zi-Xuan Wang, Michael J Pishvaian, Jordan M Winter
Isocitrate dehydrogenase 1 (IDH1) is a metabolic enzyme implicated in cancer cell metabolic reprogramming. This is underscored by the detection of functional, somatic IDH1 mutations frequently found in secondary glioblastoma. To our knowledge, there has never been a reported, validated case of an IDH1 mutation in a pancreatic ductal adenocarcinoma (PDA). Herein, we present a case of a patient with metastatic PDA that harbored a potentially actionable, albeit rare, IDH1 mutation. As part of the Know Your Tumor project (Pancreatic Cancer Action Network), a 48-year-old female was diagnosed with metastatic PDA and subsequently started on standard of care chemotherapy, during which her hepatic lesions progressed...
July 28, 2016: Cancer Biology & Therapy
Wei-Ming Li, Chih-Sheng Chiang, Wei-Chen Huang, Chia-Wei Su, Min-Yu Chiang, Jian-Yi Chen, San-Yuan Chen
We developed a surfactant-free method utilizing amifostine to stably link a targeting ligand (Herceptin) to amphiphilic gelatin (AG)-iron oxide@calcium phosphate (CaP) nanoparticles with hydrophobic curcumin (CUR) and hydrophilic doxorubicin (DOX) encapsulated in the AG core and CaP shell (AGIO@CaP-CD), respectively. This multi-functional nanoparticle system has a pH-sensitive CaP shell and degradable amphiphilic gelatin (AG) core, which enables controllable sequential release of the two drugs. The dual-targeting system of AGIO@CaP-CD (HER-AGIO@CaP-CD) with a bioligand and magnetic targeting resulted in significantly elevated cellular uptake in HER2-overexpressing SKBr3 cells and more efficacious therapy than delivery of targeting ligand alone due to the synergistic cell multi-drug resistance/apoptosis-inducing effect of the CUR and DOX combination...
December 28, 2015: Journal of Controlled Release: Official Journal of the Controlled Release Society
Shankar K Jha, Nassir Mojarad, Mario Agio, Jörg F Löffler, Yasin Ekinci
This study demonstrates the metal-enhanced fluorescence of adenine using aluminum nanoparticle arrays in the deep UV range. It achieves the reproducible intensity enhancement of intrinsic fluorescence up to 80 on well-defined aluminum nanoparticle arrays at 257 nm excitation. In addition to a high signal enhancement, a strong modification of the fluorescence emission spectrum of adenine is observed. This study illustrates that the label-free detection of DNA bases and proteins that have low intrinsic fluorescence and absorption bands in the deep UV range can be facilitated using aluminum nanostructures...
September 21, 2015: Optics Express
Shankar K Jha, Yasin Ekinci, Mario Agio, Jörg F Löffler
We report ultrasensitive and label-free detection of 2,4,6-trinitrotoluene (TNT) deposited by drop coating using deep-ultraviolet surface-enhanced resonance Raman scattering (DUV-SERRS). Well-defined aluminum nanoparticle arrays as the SERRS substrate at 257 nm excitation wavelength enabled highly reproducible and real-time detection of TNT down to the detection limit of the attogram level in quantity. This extreme sensitivity can be further improved by optimization of the nanostructured substrates. DUV-SERRS promises to have a large impact on public safety and security, as it can be readily extended to other explosives and hazardous materials...
August 21, 2015: Analyst
Elisabet Cuyàs, Salvador Fernández-Arroyo, Bruna Corominas-Faja, Esther Rodríguez-Gallego, Joaquim Bosch-Barrera, Begoña Martin-Castillo, Rafael De Llorens, Jorge Joven, Javier A Menendez
Metabolic flexibility might be particularly constrained in tumors bearing mutations in isocitrate dehydrogenase 1 (IDH1) leading to the production of the oncometabolite 2-hydroxygluratate (2HG). To test the hypothesis that IDH1 mutations could generate metabolic vulnerabilities for therapeutic intervention, we utilized an MCF10A cell line engineered with an arginine-to-histidine conversion at position 132 (R132H) in the catalytic site of IDH1, which equips the enzyme with a neomorphic α-ketoglutarate to 2HG reducing activity in an otherwise isogenic background...
May 20, 2015: Oncotarget
Diego Martín-Cano, Harald R Haakh, Karim Murr, Mario Agio
We investigate the reduction of the electromagnetic field fluctuations in resonance fluorescence from a single emitter coupled to an optical nanostructure. We find that such hybrid systems can lead to the creation of squeezed states of light, with quantum fluctuations significantly below the shot-noise level. Moreover, the physical conditions for achieving squeezing are strongly relaxed with respect to an emitter in free space. A high degree of control over squeezed light is feasible both in the far and near fields, opening the pathway to its manipulation and applications on the nanoscale with state-of-the-art setups...
December 31, 2014: Physical Review Letters
Xue-Wen Chen, Vahid Sandoghdar, Mario Agio
We provide a general theoretical platform based on quantized radiation in absorptive and inhomogeneous media for investigating the coherent interaction of light with material structures in the immediate vicinity of quantum emitters. In the case of a very small metallic cluster, we demonstrate extreme regimes where a single emitter can either counteract or enhance particle absorption by 3 orders of magnitude. For larger structures, we show that an emitter can eliminate both scattering and absorption and cloak a plasmonic antenna...
April 12, 2013: Physical Review Letters
Eleni Provatari, Vasilios Karampelas, Marianna Diomidous, John Mantas
The purpose of this study is register the opinion of nurses on the compatibility of the Nursing Information System with the provision of nursing care, and the ease of learning of the subsystem. This paper is an empirical study that was conducted using a questionnaire in Cancer and Oncology Hospital "Agios Savvas". Specifically, 121 nurses (108 women and 13 men) of all education levels participated in the survey. According to user responses, 86% agreed partially that the subsystem was easy to learn, and 40.5 % of this 86% believe that the clinical subsystem adequately supports nursing care, mainly engaged in designing the necessary processes, and followed by reducing errors...
2014: Studies in Health Technology and Informatics
Evangelia Strogyloudi, Maria-Antonietta Pancucci-Papadopoulou, Giorgio L Papadopoulos
Concentrations of Cd, Cu, Cr, Ni, Zn, Fe and metallothioneins (MTs) were measured in the gonads of Paracentrotus lividus from Amvrakikos gulf (Ionian Sea, Greece). Three natural populations were selected; two of them, growing inside the gulf (Agios Thomas and Koronisia), presented higher density and smaller body size than the population living in a coastal area just outside the gulf (Mytikas). Metal and MT levels were not elevated, with the exception of Zn, showing high values related to the reproduction stage of the sea urchins...
September 2014: Environmental Monitoring and Assessment
Patrick Berrebi, Christelle Tougard, Sophie Dubois, Zhaojun Shao, Irene Koutseri, Svetozar Petkovski, Alain J Crivelli
The Balkans are known to have a high level of biodiversity and endemism. No less than 15 taxa have been recorded in salmonids of the Salmo genus. Among them, the Prespa trout is found in only four river systems flowing into Lake Macro Prespa, three in the Former Yugoslav Republic of Macedonia and one in Greece. This is the first comprehensive survey of all streams located within the Macro Prespa Basin, encompassing the whole taxon range. A large genetic sample of 536 Prespa trout was collected mainly between 2005 and 2007...
2013: International Journal of Molecular Sciences
M Nikolopoulou, N Pasadakis, H Norf, N Kalogerakis
Mediterranean coastal regions are particularly exposed to oil pollution due to extensive industrialization, urbanization and transport of crude and refined oil to and from refineries. Bioremediation of contaminated beach sand through landfarming is both simple and cost-effective to implement compared to other treatment technologies. The purpose of the present study was to investigate the effect of alternative nutrients on biodegradation of crude oil contaminated beach sand in an effort to reduce the time required for bioremediation employing only indigenous hydrocarbon degraders...
December 15, 2013: Marine Pollution Bulletin
Sevin Turcan, Armida W M Fabius, Alexandra Borodovsky, Alicia Pedraza, Cameron Brennan, Jason Huse, Agnes Viale, Gregory J Riggins, Timothy A Chan
Mutation in the IDH1 or IDH2 genes occurs frequently in gliomas and other human malignancies. In intermediate grade gliomas, IDH1 mutation is found in over 70% of tumors. These mutations impart the mutant IDH enzyme with a neomorphic activity - the ability to synthesize 2-hydroxyglutarate (2-HG). This ability leads to a reprogramming of chromatin state, a block in differentiation, and the establishment of the glioma hypermethylator phenotype (G-CIMP). It has been hypothesized but not proven that the extensive DNA methylation that occurs in G-CIMP tumors helps maintain and "lock in" glioma cancer cells in a dedifferentiated state...
October 2013: Oncotarget
M Nikolopoulou, N Pasadakis, N Kalogerakis
Oil spills are treated as a widespread problem that poses a great threat to any ecosystem. Following first response actions, bioremediation has emerged as the best strategy for combating oil spills and can be enhanced by the following two complementary approaches: bioaugmentation and biostimulation. Bioaugmentation is one of the most controversial issues of bioremediation. Studies that compare the relative performance of bioaugmentation and biostimulation suggest that nutrient addition alone has a greater effect on oil biodegradation than the addition of microbial products because the survival and degradation ability of microbes introduced to a contaminated site are highly dependent on environmental conditions...
July 15, 2013: Marine Pollution Bulletin
Christos Nikolaidis, Moysis Orfanidis, Dimitri Hauri, Stratos Mylonas, Theodore Constantinidis
The 'Agios Philippos' lead-zinc mine in the Kirki region (NE Greece) is now closed, but its legacy of heavy metal contamination remains at the site. At present, management of the contaminated land is of major concern. The area is in a reclamation process and requires immediate remediation action, whereas human risks need to be carefully evaluated. In order to assess these risks, samples from around the mine were collected and analyzed and a scenario involving the oral, dermal, and inhaled doses of arsenic and heavy metals was formulated...
December 2013: International Journal of Environmental Health Research
Elke Neu, Mario Agio, Christoph Becher
Single silicon vacancy (SiV) color centers in diamond have recently shown the ability for high brightness, narrow bandwidth, room temperature single photon emission. This work develops a model describing the three level population dynamics of single SiV centers in diamond nanocrystals on iridium surfaces including an intensity dependent de-shelving process. Furthermore, we investigate the brightness and photostability of single centers and find maximum single photon rates of 6.2 Mcps under continuous excitation...
August 27, 2012: Optics Express
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