keyword
MENU ▼
Read by QxMD icon Read
search

Dating

keyword
https://www.readbyqxmd.com/read/29232757/-real-life-data-on-the-treatment-of-diabetic-macular-oedema-in-germany
#1
Robert G H Wilke, Robert Patrick Finger, Helmut G Sachs
Background Controlled prospective clinical trials on the treatment of diabetic macular oedema (DME) using anti-VEGF compounds show very good results in visual acuity gain over several years. To date, only limited data are available from comparable studies under real-life settings in clinical routine. However, real-life data from other indications for anti-VEGF treatment suggest that, in clinical routine, gain in visual acuity is less pronounced and cannot be maintained over a longer period of time, which is related to the significantly lower number of injections administered in clinical routine...
December 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29232711/dependence-of-prevalence-of-contiguous-pathways-in-proteins-on-structural-complexity
#2
Kelly M Thayer, Jesse C Galganov, Avram J Stein
Allostery is a regulatory mechanism in proteins where an effector molecule binds distal from an active site to modulate its activity. Allosteric signaling may occur via a continuous path of residues linking the active and allosteric sites, which has been suggested by large conformational changes evident in crystal structures. An alternate possibility is that the signal occurs in the realm of ensemble dynamics via an energy landscape change. While the latter was first proposed on theoretical grounds, increasing evidence suggests that such a control mechanism is plausible...
2017: PloS One
https://www.readbyqxmd.com/read/29232576/effects-of-oxytocin-on-cortisol-reactivity-and-conflict-resolution-behaviors-among-couples-with-substance-misuse
#3
Julianne C Flanagan, Melanie S Fischer, Paul J Nietert, Sudie E Back, Megan Moran-Santa Maria, Alexandra Snead, Kathleen T Brady
Social stress, particularly in the form of dyadic conflict, is a well-established correlate of substance use disorders (SUD). The neuropeptide oxytocin can enhance prosocial behavior and mitigate addictive behaviors. These effects may be, in part, a result of oxytocin's ability to attenuate hypothalamic-pituitary-adrenal (HPA) axis dysregulation. However, only one study to date has examined the effects of oxytocin on neuroendocrine reactivity or conflict resolution behavior among couples. Participants (N = 33 couples or 66 total participants) were heterosexual couples in which one or both partners endorsed substance misuse...
December 6, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29232554/genomic-aberrations-that-activate-d-type-cyclins-are-associated-with-enhanced-sensitivity-to-the-cdk4-and-cdk6-inhibitor-abemaciclib
#4
Xueqian Gong, Lacey M Litchfield, Yue Webster, Li-Chun Chio, Swee Seong Wong, Trent R Stewart, Michele Dowless, Jack Dempsey, Yi Zeng, Raquel Torres, Karsten Boehnke, Cecilia Mur, Carlos Marugán, Carmen Baquero, Chunping Yu, Steven M Bray, Isabella H Wulur, Chen Bi, Shaoyou Chu, Hui-Rong Qian, Philip W Iversen, Farhana F Merzoug, Xiang S Ye, Christoph Reinhard, Alfonso De Dios, Jian Du, Charles W Caldwell, María José Lallena, Richard P Beckmann, Sean G Buchanan
Most cancers preserve functional retinoblastoma (Rb) and may, therefore, respond to inhibition of D-cyclin-dependent Rb kinases, CDK4 and CDK6. To date, CDK4/6 inhibitors have shown promising clinical activity in breast cancer and lymphomas, but it is not clear which additional Rb-positive cancers might benefit from these agents. No systematic survey to compare relative sensitivities across tumor types and define molecular determinants of response has been described. We report a subset of cancers highly sensitive to CDK4/6 inhibition and characterized by various genomic aberrations known to elevate D-cyclin levels and describe a recurrent CCND1 3'UTR mutation associated with increased expression in endometrial cancer...
December 11, 2017: Cancer Cell
https://www.readbyqxmd.com/read/29232502/do-treatment-patterns-alter-beliefs-cancer-patients-hold-regarding-oral-oncolytic-agents
#5
Alla Sikorskii, Charles W Given, Barbara A Given, Eric Vachon, Victoria Marshall, John C Krauss, Asish Banik, Atreyee Majumder
OBJECTIVE: Cancer patients, particularly those prescribed oral oncolytic medications, face treatment side effects, and temporary and permanent stoppages of treatment. This research examines how events during treatment affect patients' beliefs regarding oral oncolytic medications. METHODS: 272 cancer patients initiating one of 28 oral oncolytic agents were followed for 12 weeks. Assessments of Beliefs About Medications Questionnaire (BMQ), symptoms, physical function, and depression measures were performed during telephone interviews at intake (medication start) and 4, 8, and 12 weeks...
December 12, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/29232475/front-line-therapy-of-advanced-ovarian-cancer-new-approaches
#6
J A Ledermann
Background: The 5-year survival of ovarian cancer has slowly increased but to date much of this has been due to the use of more lines of treatment rather than better first-line therapy. In this setting, there has been little improvement over the past 15 years. The introduction of new treatments to extend time to first progression and overall survival remains a key objective of clinical research. Design: The focus of research in the previous decade has been on the incorporation of anti-angiogenic therapy or dose-dense scheduling of paclitaxel (Taxol) to improve outcome...
November 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29232384/first-evidence-of-bighead-carp-wild-recruitment-in-western-europe-and-its-relation-to-hydrology-and-temperature
#7
Marco Milardi, Duane Chapman, Mattia Lanzoni, James M Long, Giuseppe Castaldelli
Bighead carp (Hypophthalmichthys nobilis) have been introduced throughout Europe, mostly unintentionally, and little attention has been given to their potential for natural reproduction. We investigated the presence of young-of-the-year bighead carp in an irrigation canal network of Northern Italy and the environmental conditions associated with spawning in 2011-2015. The adult bighead carp population of the canal network was composed by large, likely mature, individuals with an average density of 45.2 kg/ha (over 10 fold more than in the main river)...
2017: PloS One
https://www.readbyqxmd.com/read/29232355/proximal-junctional-kyphosis-inter-and-intraobserver-reliability-of-radiographic-measurements-in-adult-spinal-deformity
#8
Farbod Rastegar, Alec Contag, Alan Daniels, Jayme Hiratzka, Clifford Lin, Jason Chang, Khoi Than, Ahmed Raslan, Christopher Kong, Ngoc-Lam Nguyen, Richard Hostin, Marie Kane, Robert A Hart
STUDY DESIGN: Reliability study of radiographic measures of proximal junctional kyphosis (PJK) in patients with adult spinal deformity (ASD). OBJECTIVE: To assess impacts of level of proximal endpoint and vertebral fracture on reliability of measurement of junctional kyphosis. SUMMARY OF BACKGROUND DATA: Radiographic assessment is important in determining management of patients with PJK or proximal junctional failure (PJF). No study to date has evaluated the reliability of radiographic measurement of the junctional kyphotic angle after surgery for ASD...
January 1, 2018: Spine
https://www.readbyqxmd.com/read/29232280/accuracy-of-self-reported-hypertension-a-systematic-review-and-meta-analysis
#9
Vivian S S Gonçalves, Keitty R C Andrade, Kenia M B Carvalho, Marcus T Silva, Mauricio G Pereira, Tais F Galvao
OBJECTIVE: To estimate the sensitivity and specificity of self-reported hypertension (HTN) as compared with the clinical diagnosis in epidemiological studies. METHODS: We searched MEDLINE, Embase, Scopus, Web of Science, LILACS, Google Scholar, and ProQuest Dissertations & Theses Global: Health & Medicine databases. In addition, we screened the references' lists of relevant reports to identify potentially eligible articles. There were no date or language restrictions...
December 11, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/29232265/the-value-of-preoperative-exercise-and-education-for-patients-undergoing-total-hip-and-knee-arthroplasty-a-systematic-review-and-meta-analysis
#10
Rebecca Moyer, Kathy Ikert, Kristin Long, Jacquelyn Marsh
BACKGROUND: Existing evidence regarding the value of preoperative education and/or exercise (prehabilitation) for patients undergoing total joint replacement is conflicting. The purpose of this study was to conduct an updated, comprehensive systematic review with meta-analyses to determine the longitudinal effects and efficacy of prehabilitation on postoperative outcomes in patients undergoing total hip arthroplasty (THA) or total knee arthroplasty (TKA). METHODS: We searched 11 electronic databases (MEDLINE, AMED, CINAHL, Embase, Scopus, ProQuest, PEDro, SportDiscus, PsycINFO, and Cochrane) from their inception to May 2016 for randomized controlled trials that compared changes in pain, function, strength, anxiety, and hospital length of stay following THA or TKA...
December 12, 2017: JBJS Reviews
https://www.readbyqxmd.com/read/29232181/resna-position-on-the-application-of-power-mobility-devices-for-pediatric-users
#11
Lauren Rosen, Teresa Plummer, Andrina Sabet, Michelle L Lange, Roslyn Livingstone
This is an official RESNA Position Paper on Clinical and Professional Practice. As such, it has been prepared in accordance with the specific guidelines and approval process defined by the RESNA Board of Directors for Position Papers. See http://www.resna.org/knowledge-center/position-papers-white-papers-and-provision-guides for a complete description of this procedure. Key aspects of this procedure include: Establishment of a Working Group of three or more experts to author the paper, using evidence from the published literature, documented best practices, and other input from experts in the field as the basis for the content...
December 12, 2017: Assistive Technology: the Official Journal of RESNA
https://www.readbyqxmd.com/read/29232151/adjuvanted-influenza-vaccines
#12
John S Tregoning, Ryan F Russell, Ekaterina Kinnear
In spite of current influenza vaccines being immunogenic, evolution of the influenza virus can reduce efficacy and so influenza remains a major threat to public health. One approach to improve influenza vaccines is to include adjuvants; substances that boost the immune response. Adjuvants are particularly beneficial for influenza vaccines administered during a pandemic when a rapid response is required or for use in patients with impaired immune responses, such as infants and the elderly. This review outlines the current use of adjuvants in human influenza vaccines, including what they are, why they are used and what is known of their mechanism of action...
December 12, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29232141/zsm-5-zeolite-complete-al-bond-connectivity-and-implications-on-structure-formation-from-solid-state-nmr-and-quantum-chemistry-calculations
#13
Eddy Dib, Tzonka Mineva, Emmanuel Véron, Vincent Sarou-Kanian, Franck Fayon, Bruno Alonso
The Al site distribution in the structurally complex and industrially important ZSM-5 zeolite is determined by studying the spectroscopic response of Al(OSi)4 units and using a self-consistent combination of up-to-date solid-state NMR correlations (29Si-27Al and 1H-27Al D-HMQC) and quantum chemistry methods (DFT-D). To unravel the driving forces behind specific Al sitting positions our approach focus on ZSM-5 containing its more efficient OSDA, tetrapropylammonium.
December 12, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/29232121/selectively-targeting-the-kinome-conserved-lysine-of-pi3k%C3%AE-as-a-general-approach-to-covalent-kinase-inhibition
#14
Samuel E Dalton, Lars Dittus, Daniel A Thomas, Maire A Convery, Joao Nunes, Jacob T Bush, John P Evans, Thilo Werner, Marcus Bantscheff, John A Murphy, Sebastien Campos
Selective covalent inhibition of kinases by targeting poorly conserved cysteines has proven highly fruitful to date in the development of chemical probes and approved drugs. However, this approach is limited to ~200 kinases possessing such a cysteine near the ATP-binding pocket. Herein, we report a novel approach to achieve selective, irreversible kinase inhibition, by targeting the conserved catalytic lysine residue. We have illustrated our approach by developing selective, covalent PI3Kδ inhibitors that exhibit nanomolar potency in cellular assays, and a duration of action >48 h in CD4+ T cells...
December 12, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29232119/catalytic-mechanism-of-fungal-lytic-polysaccharide-monooxygenases-investigated-by-first-principles-calculations
#15
Luca Bertini, Raffaella Breglia, Matteo Lambrughi, Piercarlo Fantucci, Luca De Gioia, Marco Borsari, Marco Sola, Carlo Augusto Bortolotti, Maurizio Bruschi
Lytic polysaccharide monooxygenases (LPMOs) are Cu-containing enzymes that facilitate the degradation of recalcitrant polysaccharides by the oxidative cleavage of glycosidic bonds. They are gaining rapidly increasing attention as key players in biomass conversion, especially for the production of second-generation biofuels. Elucidation of the detailed mechanism of the LPMO reaction is a major step toward the assessment and optimization of LPMO efficacy in industrial biotechnology, paving the way to utilization of sustainable fuel sources...
December 12, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29232071/claims-procedure-for-plans-providing-disability-benefits-90-day-delay-of-applicability-date-final-rule-delay-of-applicability-date
#16
(no author information available yet)
This document delays for ninety (90) days--through April 1, 2018--the applicability of a final rule amending the claims procedure requirements applicable to ERISA-covered employee benefit plans that provide disability benefits (Final Rule). The Final Rule was published in the Federal Register on December 19, 2016, became effective on January 18, 2017, and was scheduled to become applicable on January 1, 2018. The delay announced in this document is necessary to enable the Department of Labor to carefully consider comments and data as part of its effort, pursuant to Executive Order 13777, to examine regulatory alternatives that meet its objectives of ensuring the full and fair review of disability benefit claims while not imposing unnecessary costs and adverse consequences...
November 29, 2017: Federal Register
https://www.readbyqxmd.com/read/29232003/molecular-dynamics-insights-into-the-structure-function-and-substrate-binding-mechanism-of-mucin-desulfating-sulfatase-of-gut-microbe-bacteroides-fragilis
#17
Ardhendu Bhusan Praharaj, Budheswar Dehury, Namita Mahapatra, Shantanu Kumar Kar, Santosh Kumar Behera
The complex and dynamic consortia of microbiota that harbors the human gastrointestinal tract contributes ominously to the maintenance of health, the onset and progression of diverse spectrum of disorders. The capability of these enteric microbes to bloom within the gut mucosal milieu is often associated to the glycan metabolism of mucin-degrading bacteria. Accruing evidences suggests that the desulfation of mucin is a rate-limiting step in mucin degradation mechanism by colonic bacterial mucin-desulfating sulfatase enzymes (MDS) enzymes...
December 12, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29231961/a-mechanism-by-which-astragalus-polysaccharide-protects-against-ros-toxicity-through-inhibiting-the-protein-dephosphorylation-of-boar-sperm-preserved-at-4-%C3%A2-c
#18
Jieli Fu, Qiangzhen Yang, Yuhua Li, Peifei Li, Lirui Wang, Xinhong Li
Numerous studies have shown that Astragalus polysaccharide (APS) has strong antioxidant effects and high practical value for preserving semen at low temperatures in vitro. However, to date, little attention has been paid to the precise mechanism of APS in sperm preservation at 4 °C. Thus, to gain further insight into the protective effects of APS, the present study was performed to assess the changes in sperm quality parameters, antioxidant capacity, ATP content and protein phosphorylation levels. Here, we demonstrated that supplementation with APS could effectively preserve boar sperm quality parameters such as sperm motility, acrosome integrity and mitochondrial membrane potential...
December 12, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29231944/stability-of-plant-virus-based-nanocarriers-in-gastrointestinal-fluids
#19
Alberto Berardi, David J Evans, Francesca Baldelli Bombelli, George P Lomonossoff
Cowpea mosaic virus (CPMV) is a plant virus which is being extensively investigated as a drug delivery and vaccine nanocarrier for parenteral administration. However, to date little is known about the suitability of plant-based nanocarriers for oral delivery. In this study, the colloidal (i.e. aggregation), physical (i.e. denaturation) and chemical (i.e. digestion of the polypeptides) stability of CPMV and its empty virus-like particles (eVLPs) in conditions resembling the gastrointestinal fluids were evaluated...
December 12, 2017: Nanoscale
https://www.readbyqxmd.com/read/29231923/temporally-inter-comparable-maps-of-terrestrial-wilderness-and-the-last-of-the-wild
#20
James R Allan, Oscar Venter, James E M Watson
Wilderness areas, defined as areas free of industrial scale activities and other human pressures which result in significant biophysical disturbance, are important for biodiversity conservation and sustaining the key ecological processes underpinning planetary life-support systems. Despite their importance, wilderness areas are being rapidly eroded in extent and fragmented. Here we present the most up-to-date temporally inter-comparable maps of global terrestrial wilderness areas, which are essential for monitoring changes in their extent, and for proactively planning conservation interventions to ensure their preservation...
December 12, 2017: Scientific Data
keyword
keyword
38084
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"