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https://www.readbyqxmd.com/read/28441826/-a-childhood-onset-rapid-onset-dystonia-parkinsonism-family-with-atp1a3-gene-mutation-and-literatures-review
#1
C L Zhang, F Yin, F He, N Gai, Z Q Shi, J Peng
Objective: To explore clinical characteristics, treatment, and prognosis of a family with childhood-onset rapid-onset dystonia parkinsonism (RDP) caused by ATP1A3 gene mutation and review literatures. Method: The clinical data of a RDP child, his brother and mother had been analyzed retrospectively. This family was admitted to Xiangya Hospital in January 2016. DNA samples were analyzed by the next-generation sequencing and confirmed by Sanger sequencing. Related literature from PubMed, Online Mendelian Inheritance in Man (OMIM), CNKI and Wanfang databases to date (up to October 2016) with"Rapid-onset dystonia-parkinsonism"RDP"DYT12" as key words was reviewed...
April 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/28441772/structural-and-biochemical-properties-of-novel-self-cleaving-ribozymes
#2
REVIEW
Ki-Young Lee, Bong-Jin Lee
Fourteen well-defined ribozyme classes have been identified to date, among which nine are site-specific self-cleaving ribozymes. Very recently, small self-cleaving ribozymes have attracted renewed interest in their structure, biochemistry, and biological function since the discovery, during the last three years, of four novel ribozymes, termed twister, twister sister, pistol, and hatchet. In this review, we mainly address the structure, biochemistry, and catalytic mechanism of the novel ribozymes. They are characterized by distinct active site architectures and divergent, but similar, biochemical properties...
April 24, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28441727/job-strain-and-casual-blood-pressure-distribution-looking-beyond-the-adjusted-mean-and-taking-gender-age-and-use-of-antihypertensives-into-account-results-from-elsa-brasil
#3
Leidjaira Lopes Juvanhol, Enirtes Caetano Prates Melo, Marilia Sá Carvalho, Dóra Chor, José Geraldo Mill, Rosane Härter Griep
Methodological issues are pointed to as the main sources of inconsistencies in studies about the association between job strain and blood pressure (BP)/hypertension. Our aim was to analyze the relationship between job strain and the whole BP distribution, as well as potential differences by gender, age, and use of antihypertensives. Additionally, we addressed issues relating to the operationalization of the exposure and outcome variables that influence the study of their inter-relations. We evaluated the baseline date of 12,038 participants enrolled in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) (2008-2010), a multicenter cohort study of 35-74-year-old civil servants...
April 22, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28441700/ultrasound-based-renal-sympathetic-denervation-for-the-treatment-of-therapy-resistant-hypertension-a-single-center-experience
#4
Karl Fengler, Robert Höllriegel, Thomas Okon, Thomas Stiermaier, Karl-Philipp Rommel, Stephan Blazek, Christian Besler, Max von Roeder, Martin Petzold, Gerhard Schuler, Philipp Lurz
INTRODUCTION: The effectiveness of renal sympathetic denervation (RDN) as a treatment for therapy-resistant hypertension has been doubted as the Simplicity-HTN-3 trial was unable to show any treatment benefit over sham procedure. This might partly be explained by a high procedural variability in treatment with radiofrequency-based catheters. Recently, newer systems for RDN, like ultrasound-based devices, have been introduced into practice. To date however, data on their effectiveness for the treatment of resistant hypertension are scarce...
June 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28441633/a-health-intervention-or-a-kitchen-appliance-household-costs-and-benefits-of-a-cleaner-burning-biomass-fuelled-cookstove-in-malawi
#5
Katie Cundale, Ranjeeta Thomas, Jullita Kenala Malava, Deborah Havens, Kevin Mortimer, Lesong Conteh
Pneumonia is the leading cause of mortality for children under five years in sub-Saharan Africa. Household air pollution has been found to increase risk of pneumonia, especially due to exposure from dirty burning biomass fuels. It has been suggested that advanced stoves, which burn fuel more efficiently and reduce smoke emissions, may help to reduce household air pollution in poor, rural settings. This qualitative study aims to provide an insight into the household costs and perceived benefits from use of the stove in Malawi...
April 13, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28441620/cognitive-behavioral-therapy-is-effective-in-misophonia-an-open-trial
#6
Arjan E Schröder, Nienke C Vulink, Arnoud J van Loon, Damiaan A Denys
BACKGROUND: Misophonia is a psychiatric disorder in which ordinary human sounds like smacking or chewing provoke intense anger and disgust. Despite the high burden of this condition, to date there is no evidence-based treatment available. In this study we evaluated the efficacy of cognitive behavioral therapy (CBT) and investigated whether clinical or demographic characteristics predicted treatment response. METHODS: Ninety patients with misophonia received eight bi-weekly group CBT sessions...
April 18, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28441589/nutrient-stress-induced-chromatin-changes-in-plants
#7
REVIEW
David Secco, James Whelan, Hatem Rouached, Ryan Lister
The ability of plants to appropriately respond to the soil nutrient availability is of primary importance for their development and to complete their life cycle. Deciphering these multifaceted adaptive mechanisms remains a major challenge for scientists to date. Recent technological breakthroughs now enable to assess the dynamism and complexity of these processes at unprecedented resolution. In this review, we present some of the most recent findings on the involvement of histone modifications, histone variants and DNA methylation in response to nutrient stresses as well as discussing the potential roles these chromatin changes could serve as priming or as trans-generational stress memory mechanisms...
April 22, 2017: Current Opinion in Plant Biology
https://www.readbyqxmd.com/read/28441575/estimates-of-recovery-of-the-penobscot-river-and-estuarine-system-from-mercury-contamination-in-the-1960-s
#8
Peter H Santschi, Kevin M Yeager, Kathleen A Schwehr, Kimberly J Schindler
Mercury (Hg) was discharged in the late 1960s into the Penobscot River by a chlor-alkali production facility, HoltraChem. Using total Hg concentration profiles from 56 stations (58 sediment cores) in the Penobscot River (PBR), Mendall Marsh (MM), Orland River (OR) and Penobscot Estuary (ES), and sediment accumulation rates derived using detailed profiles of total Hg concentrations and radionuclide activities ((137)Cs, (239,240)Pu, (210)Pb), recovery from system-wide Hg pollution was assessed. Total Hg concentration profiles showed sharp maxima at depths attributed in time to a 1967 release date, and were divided into two sections: the first 21years (1967-1988; rapid recovery), and the recent 21years (1988-2009; slower recovery)...
April 22, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28441560/evolution-fangtastic-venoms-underpin-parasitic-mimicry
#9
Martin I Taylor
Venomous teeth are rare in fishes, which typically utilise spines for defence. A new study reveals the evolutionary origins of fangs and venom in the Nemophini blennies and shows that, in contrast to snakes and lizards, the fangs pre-date the venom.
April 24, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28441545/targeted-mass-spectrometry-an-emerging-powerful-approach-to-unblock-the-bottleneck-in-phosphoproteomics
#10
REVIEW
Nerea Osinalde, Kerman Aloria, Miren J Omaetxebarria, Irina Kratchmarova
Following the rapid expansion of the proteomics field, the investigation of post translational modifications (PTM) has become extremely popular changing our perspective of how proteins constantly fine tune cellular functions. Reversible protein phosphorylation plays a pivotal role in virtually all biological processes in the cell and it is one the most characterized PTM up to date. During the last decade, the development of phosphoprotein/phosphopeptide enrichment strategies and mass spectrometry (MS) technology has revolutionized the field of phosphoproteomics discovering thousands of new site-specific phosphorylations and unveiling unprecedented evidence about their modulation under distinct cellular conditions...
April 17, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28441458/evidence-that-promotion-of-male-circumcision-did-not-lead-to-sexual-risk-compensation-in-prioritized-sub-saharan-countries
#11
Chyun-Fung Shi, Michael Li, Jonathan Dushoff
BACKGROUND: WHO and UNAIDS prioritized 14 eastern and southern African countries with high HIV and low male circumcision prevalence for a voluntary medical male circumcision (VMMC) scale-up in 2007. Because circumcision provides only partial protection against HIV infection to men, the issue of possible risk compensation in response to VMMC campaigns is of particular concern. In this study, we looked at population-level survey data from the countries prioritized by WHO for a VMMC scale-up...
2017: PloS One
https://www.readbyqxmd.com/read/28441428/increased-long-term-risk-of-major-adverse-cardiovascular-events-in-patients-with-carbon-monoxide-poisoning-a-population-based-study-in-taiwan
#12
Chung-Shun Wong, Ying-Chin Lin, Li-Chin Sung, Tzu-Ting Chen, Hon-Ping Ma, Yung-Ho Hsu, Shin-Han Tsai, Yuh-Feng Lin, Mei-Yi Wu
BACKGROUND: Carbon monoxide (CO) poisoning may cause toxicity to the cardiovascular system. However, the association between CO poisoning and the risk of major adverse cardiovascular events (MACE) remains unestablished. We investigated the incidence of MACE after CO poisoning in Taiwan and evaluated whether CO-poisoned individuals had a higher risk of MACE than did the general population. METHODS: Using Taiwan's National Health Insurance Research Database (NHIRD) during 2005-2013, a nationwide population-based cohort study was conducted among patients who experienced CO poisoning between 2005 and 2013...
2017: PloS One
https://www.readbyqxmd.com/read/28441422/automated-detection-of-hospital-outbreaks-a-systematic-review-of-methods
#13
Brice Leclère, David L Buckeridge, Pierre-Yves Boëlle, Pascal Astagneau, Didier Lepelletier
OBJECTIVES: Several automated algorithms for epidemiological surveillance in hospitals have been proposed. However, the usefulness of these methods to detect nosocomial outbreaks remains unclear. The goal of this review was to describe outbreak detection algorithms that have been tested within hospitals, consider how they were evaluated, and synthesize their results. METHODS: We developed a search query using keywords associated with hospital outbreak detection and searched the MEDLINE database...
2017: PloS One
https://www.readbyqxmd.com/read/28441342/of-oestrogens-and-sperm-a-review-of-the-roles-of-oestrogens-and-oestrogen-receptors-in-male-reproduction
#14
REVIEW
Pavla Dostalova, Eva Zatecka, Katerina Dvorakova-Hortova
The crucial role that oestrogens play in male reproduction has been generally accepted; however, the exact mechanism of their action is not entirely clear and there is still much more to be clarified. The oestrogen response is mediated through oestrogen receptors, as well as classical oestrogen receptors' variants, and their specific co-expression plays a critical role. The importance of oestrogen signalling in male fertility is indicated by the adverse effects of selected oestrogen-like compounds, and their interaction with oestrogen receptors was proven to cause pathologies...
April 25, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28441288/investigation-of-optically-stimulated-luminescence-and-signal-fading-properties-of-several-materials
#15
W Geoffrey West, Kimberlee J Kearfott, Chun Yong Seow
Optically stimulated luminescence (OSL) dosimetry involves the illumination of an irradiated sample on an appropriate material to produce a stimulated emission of light, whose intensity is indicative of the radiation dose. This technique is currently used for personnel dosimetry, environmental dosimetry, and geological dating applications. While a great deal of published research focusing on α-Al2O3:C and natural materials used for geological dating exist, relatively little is known about the OSL properties of thermoluminescent (TL) materials...
June 2017: Health Physics
https://www.readbyqxmd.com/read/28441276/augs-consensus-statement-association-of-anticholinergic-medication-use-and-cognition-in-women-with-overactive-bladder
#16
(no author information available yet)
Overactive bladder affects a significant portion of the overall population and has substantial impact on daily activities and quality-of-life. When considering treatment, behavioral therapies should be instituted first, followed by medical therapies. Anticholinergic medications and beta-3 agonists are often used as initial pharmacologic therapy, but caution should be taken in prescribing anticholinergic medications in frail or cognitively impaired patients. Recently, concerns have developed regarding anticholinergic medications and the associated risk of cognitive impairment, dementia, and Alzheimer disease in the general population...
May 2017: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/28441185/exploring-factors-associated-with-patients-adherence-to-antihypertensive-drugs-among-people-with-primary-hypertension-in-the-united-kingdom
#17
Amanj I Kurdi, Li-Chia Chen, Rachel A Elliott
OBJECTIVE: To explore factors associated with adherence to antihypertensive drugs overall (therapy adherence) and to particular classes (class adherence) in hypertensive patients. METHODS: The current retrospective cohort study included adults with primary hypertension identified in the UK Clinical Practice Research Datalink from April 2006 to March 2013. Individuals were followed from the date of first-ever antihypertensive drug class (class adherence) prescribed and from the date of the first-ever antihypertensive drug (therapy adherence) issued to the earliest of study end, patient leaving the database, or death...
April 22, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28441171/prevalence-of-psychopathology-in-children-of-parents-with-mental-illness-and-or-addiction-an-up-to-date-narrative-review
#18
Sophie Leijdesdorff, Karin van Doesum, Arne Popma, Rianne Klaassen, Therese van Amelsvoort
PURPOSE OF REVIEW: Children of parents with a mental illness and/or addiction are at high risk for developing a mental illness themselves. Parental mental illness is highly prevalent leading to a serious number of children at high risk. The aim of this review is to give an up-to-date overview of psychopathology in children of parents with various mental illnesses and/or addiction, based on recent literature. RECENT FINDINGS: Worldwide, 15-23% of children live with a parent with a mental illness...
April 22, 2017: Current Opinion in Psychiatry
https://www.readbyqxmd.com/read/28441152/cryoablation-in-the-management-of-barrett-s-esophagus
#19
Anouk Overwater, Bas L A M Weusten
PURPOSE OF REVIEW: Providing an overview on types of cryotherapy for esophageal application and their role in the management of Barrett's esophagus. RECENT FINDINGS: Recent studies have involved multiple types of cryotherapy including cryospray techniques that use either liquid nitrogen or carbon dioxide as the cryogenic fluid, and the CryoBalloon focal ablation device that uses nitrous oxide. Overall, studies report cryotherapy to be safe and effective in eradicating Barrett's epithelium...
April 24, 2017: Current Opinion in Gastroenterology
https://www.readbyqxmd.com/read/28441118/mechanisms-of-hippocampal-aging-and-the-potential-for-rejuvenation
#20
Xuelai Fan, Elizabeth G Wheatley, Saul A Villeda
The past two decades have seen remarkable progress in our understanding of the multifactorial drivers of hippocampal aging and cognitive decline. Recent findings have also raised the possibility of functional rejuvenation in the aged hippocampus. In this review, we aim to synthesize the mechanisms that drive hippocampal aging and evaluate critically the potential for rejuvenation. We discuss the functional changes in synaptic plasticity and regenerative potential of the aged hippocampus, followed by mechanisms of microglia aging, and assess the cross talk between these proaging processes...
April 24, 2017: Annual Review of Neuroscience
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