obsesive

The metabolites produced by the gut microbiota have been reported as crucial agents against obesity; however, their key targets have not been revealed completely in complex microbiome systems. Hence, the aim of this study was to decipher promising prebiotics, probiotics, postbiotics, and more importantly, key target(s) via a network pharmacology approach. First, we retrieved the metabolites related to gut microbes from the gutMGene database. Then, we performed a meta-analysis to identify metabolite-related targets via the similarity ensemble approach (SEA) and SwissTargetPrediction (STP), and obesity-related targets were identified by DisGeNET and OMIM databases...

INTRODUCTION: Type-2 Diabetes (T2D) is highly associated with peripheral artery disease (PAD), with both PAD and T2D highly associated with chronic inflammation. High mobility group box 1 (HMGB1) is key in regulating both inflammation and diabetes. Acetylated HMGB1 is the extracellularly released form of HMGB1 from post translational modifications (PTM) that occur after nuclear HMGB1 turnover. Acetylated HMGB1 has significant cytokine/chemokine activity. Plasma HMGB1 high molecular weight (HMW) complexes have been identified in the literature as PTM in chronic inflammation...

Lichen sclerosus is a chronic disease of unknown etiology that can occur in the genital area of both sexes. Balanitis xerotica obliterans (BXO) occurs only in the genital area of men and typically affects the foreskin, penile glans, and/or the meatus. In the present report, an observational, descriptive, and retrospective epidemiological clinical study of available data between January 2006 and December 2020 in patients diagnosed with BXO from the casuistic of CMI DERMAMED (Târgu Mureș, Romania) was performed...

The metabolic syndrome is a cluster of risk factors that are associated with increased risk of cardiovascular diseases and Type 2 diabetes mellitus. The aim was to study the association of plasma procalcitonin with various components of metabolic syndrome (abdominal obsesity, dyslipidemia, hypertension and hyperglycemia) and insulin resistance and compare with healthy controls. In addition, we tried to gauge the association of plasma procalcitonin with complications of metabolic syndrome at presentation. MATERIAL: This was a hospital based observational comparative study on 30 cases of metabolic syndrome in hospital wards and OPD of SMS Medical College, Jaipur and 30 accompanying healthy controls...

INTRODUCTION: It is known that patients with anorexia nervosa (AN) display social difficulties like social responsiveness and high levels of autistic behaviors such as rigidity, narrow interests of food and weight; however it is not clear whether they have comorbid Autism Spectrum Disorders (ASD) or it is about acute phase of illness. In this study it is aimed to investigate autistic traits and social responsiveness in adolescents with AN. METHODS: Study group was consisted of 39 female AN patients aged between 12-18 years...

This study evaluated the anti-obesity effect and intestinal health of obese rats treated with Mucuna pruriens (MP), focusing on food consumption and somatic, biochemical, and histological parameters. A total of 32 adult male Wistar rats were initially randomized into a healthy group (HG, n = 16) which consumed a control diet and an obese group (OG, n = 16) which consumed a cafeteria diet for eight weeks. They were then subdivided into four groups: healthy (HG, n = 8); healthy treated with MP (HGMP, n = 8); obese (OG, n = 8); obese treated with MP (OGMP, n = 8), with consumption of their respective diets continuing for another eight weeks; the treated groups received 750 mg kg-1 of MP extract via gavage...

Extracellular vesicles (EVs) have an important role in mediating intercellular signaling in inflammation and affect the kinetics of wound healing, however, an understanding of the mechanisms regulating these responses remains limited. Therefore, we have focused on the use of cutaneous injury models in which to study the biology of EVs on the inflammatory phase of wound healing. For this, the foreign body response using sterile subcutaneous polyvinylalcohol (PVA) sponges is ideally suited for the parallel analysis of immune cells and EVs without the need for tissue dissociation, which would introduce additional variables...

Knee dislocation is an infrequent complication after rotating hinge total knee arthroplasty (RHTKA). The aim of the present study was to describe our experience with dislocating RHTKA in a consecutive prospective large series, its occurrence rate, causative mechanisms and to perform a review of available literature. In total, six dislocations were observed in 303 RHTKA procedures (NexGen RHK, ZimmerBiomet, Warsaw, Indiana, US) at a mean of 10 (range, 2 - 24) months after surgery. This results in a 2% dislocation rate, which is lower than the 3...

OBJECTIVE: To observe the effect of electroacupuncture (EA) of " biaoben acupoint combination" on appetite, body fat, insulin sensitivity and central sensitivity of cholecystokinin (CCK) in obese rats with insulin resistance (IR), and to explore the mechanism of EA on improving obesity with insulin resistance. METHODS: Among the fifty 8-week-old healthy SPF male Wistar rats, 10 rats were randomly selected and fed with normal diet; after 8 weeks, 8 rats were randomly selected as a normal group...

Along with the developing technology in the modern age, physical activity had decreased considerably in children and adolescents alike with a concomittant and rapid increase in the prevalence of childhood obsesity. The purpose of the present study is to measure the levels of serum nesfatin-1 and irisin in obese children. The present study was carried out with a total of 62 children, including 32 obese children diagnosed between June 2017 and October 2017 and 30 healthy children. Serum nesfatin-1, irisin, SOD, MDA, fasting blood glucose, total cholesterol (TC), triglyceride (TG), HDL-C, LDL-C, aspartate amino transferase (AST), alanine amino transferase (ALT)), blood urea nitrogen (BUN), C-reactive protein (CRP), calcium (Ca), sodium (Na), potassium (P), chromium (Cr), ferritin, and vitamin B12 data were collected for each patient...

INTRODUCTION: There appears to be a link between weight loss and improved mental health, but less is known about how using unhealthy weight-loss strategies impacts the odds of reporting depression. METHODS: This study includes respondents from the National Health and Nutrition Examination Survey from 2005 to 2014 who attempted to lose weight over the past year. Analysis occurred in 2017. Multivariable logistic regression was used to describe associations between all weight-loss strategies, including those grouped as unhealthy (smoking, vomiting, laxatives, skipping meals, and using diet pills), and the adjusted odds of depression (Patient Health Questionnaire-9 score ≥10)...

OBJECTIVE: To document the perception of body weight, the variables that are associated with a correct perception of it and with the perception about the probability of developing obesity at short-term in Mexican adult population. MATERIALS AND METHODS: We used data from the Perception of obsesity, eating behavior and physical activity questionnaire (POCAA, by its Spanish acronym), as well as household and anthropometric measurements obtained at Ensanut MC during May and October of 2016...

Dong Y, Qi B, Feng XY, Jiang CM. Meta-analysis of Barrett's esophagus in China. World J Gastroenterol 2013;19(46):8770-8779 The disease pattern of Barrett's esophagus (BE) in China is poorly characterised particularly in comparison with other developed countries. This meta-analysis of 3873 cases of BE collated from 69 clinical studies conducted in 25 provinces between 2000 and 2011 investigated the epidemiology and characteristics of BE in China compared to Western countries. The total endoscopic detection rate of BE was 1...

SESSION TYPE: Asthma Predictors and OutcomesPRESENTED ON: Wednesday, October 24, 2012 at 02:45 PM - 04:15 PMPURPOSE: Obesity is associated with an increased risk for asthma exacerbations and represents an understudied phenotype. However, little is known with regards to the association of BMI and near fatal Asthma (NFA)METHODS: We conducted a retrospective analysis of patients who were discharged from the hospital with a diagnosis of acute asthma exacerbation. Patients who required intubation during the course of their hospitalization were defined as NFA and the rest were analyzed collectively as non near-fatal asthma (non-NFA)...

OBJECTIVE: Investigate the relationship between body satisfaction, attitudes toward body and obesity, diet quality and emotional health in a group of university students. The initial hypothesis was that attitudes to thinness and fear of obesity induces weight control behaviours and lower diet quality. METHODS: 55 women of 19-25 years. The relationship between body mass index (BMI), diet quality (DQ), restrictive behaviours, eating attitudes (EDI-2, CIMEC) and attitudes toward obesity (AFA) was analyzed...

BACKGROUND: Obesity and risk of asthma are linked. Different distributions of adiposity, such as visceral, subcutaneous or ectopic adiposity, may affect asthma risk differently. OBJECTIVE: To explore the association of different adiposity types with self-reported asthma, bronchial inflammation and lung function, accounting for possible effect modifiers, such as atopy and gender. METHODS: In a general population sample of 3471 persons aged 19-72, visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) were measured by ultrasound, and fat percentage by bio-impedance...

Polycystic ovary syndrome (PCOS) is responsible for most cases of anovulatory infertility. Hyperandrogenism, follicle excess and follicular arrest play a fundamental role that is amplified by obsesity and particularly by visceral fat excess. Hyperinsulinism is the main culprit in this aggravation. The impact of obseity on female fertility also involves extra-ovarian phenomena, and particularly negative effects on the endometrium that can lead to implantation failure and miscarriage

OBJECTIVE: Programs aimed at obesity prevention among elementary school age children have failed. In the present study, we analyzed the association between parental and child food preferences and determined whether this is influenced by the parents' gender and socio-economic status. MATERIAL AND METHODS: We invited 300 children from a state elementary school (SES) and368 from a private middle class school (PMCS) to participate. A questionnaire was given to each parent to complete together with another questionnaire asking questions about their child...

Numerous association studies have been performed to evaluate the relationship between the angiotensinogen gene and the essential hypertension, but their results are conflicting. The conflicting results may be explained by methodological reasons, particularly genetic differences in the population samples, phenotypic differences in the hypertensive populations analyzed, lack of appropriate control for other hypertension risk factors in some studies, or limited statistical power among many studies. Furthermore, hypertension is a public health issue of great relevance in Baleric Islands (Spain)...

BACKGROUND: Obesity and overweight have been described as factors associated with asthma. Our aim was to evaluate the role obesity plays on asthma in children. SCOPE AND SUBJECTs: A study carried out on children and teenagers between 8 and 15 years of age, chosen for a cluster-type random sampling from children who studied in 80 schools, which represents 30% of the schools in the city of Valencia. MATERIAL AND METHODS: The analysed data was organized into two groups, obese (from the Body Mass Index (Kg/m2)), showing children with a percentile over 85% of the measuring reference for the Spanish population) and non obese, when they did not fulfil this condition...