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https://www.readbyqxmd.com/read/29241283/-there-is-no-season-for-gifts
#1
Klaus Lieb, Cora Koch
Gifts and payments from pharmaceutical manufacturers to medical doctors constitute a conflict of interest, which may lead to an undue influence on prescribing behavior. In Germany, 35 research-based pharmaceutical companies, organized in the "Verband der forschenden Arzneimittelhersteller (VfA)" paid € 562 million to medical doctors and hospitals in 2016. Of these, € 356 million were paid for clinical trials and non-interventional studies, € 105 million for sponsored presentations and CME and € 101 million went to hospitals and other organizations for sponsoring, consulting and events...
December 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29241263/systematic-review-of-oral-therapy-for-the-treatment-of-symptoms-of-bladder-pain-syndrome-the-brazilian-guidelines
#2
Thaís Guimarães Dos Santos, Isabela Albuquerque Severo de Miranda, Christiana Campani Nygaard, Lucas Schreiner, Rodrigo de Aquino Castro, Jorge Milhen Haddad
Interstitial cystitis (IC), including bladder pain syndrome (BPS), is a chronic and debilitating disease that mainly affects women. It is characterized by pelvic pain associated with urinary urgency, frequency, nocturia and negative urine culture, with normal cytology. In 2009, the Society for Urodynamics and Female Urology (SUFU) defined the term IC/BPS as "an unpleasant sensation (pain, pressure, and discomfort) perceived to be related to the urinary bladder, associated with lower urinary tract symptoms for more than 6 weeks duration, in the absence of infection or other identifiable causes...
December 14, 2017: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/29241084/neoadjuvant-radiotherapy-combined-with-capecitabine-and-sorafenib-in-patients-with-advanced-kras-mutated-rectal-cancer-a-phase-i-ii-trial-sakk-41-08
#3
Roger von Moos, Dieter Koeberle, Sabina Schacher, Stefanie Hayoz, Ralph C Winterhalder, Arnaud Roth, György Bodoky, Panagiotis Samaras, Martin D Berger, Daniel Rauch, Piercarlo Saletti, Ludwig Plasswilm, Daniel Zwahlen, Urs R Meier, Pu Yan, Paola Izzo, Dirk Klingbiel, Daniela Bärtschi, Kathrin Zaugg
BACKGROUND: KRAS mutation occurs in ∼40% of locally advanced rectal cancers (LARCs). The multitarget tyrosine kinase inhibitor sorafenib has radiosensitising effects and might improve outcomes for standard preoperative chemoradiotherapy in patients with KRAS-mutated LARC. METHODS: Adult patients with KRAS-mutated T3/4 and/or N1/2M0 LARC were included in this phase I/II study. The phase I dose-escalation study of capecitabine plus sorafenib and radiotherapy was followed by a phase II study assessing efficacy and safety...
December 11, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/29241027/when-forensic-odontology-met-biochemistry-multidisciplinary-approach-in-forensic-human-identification
#4
REVIEW
Joe Adserias-Garriga, Christian Thomas, Douglas H Ubelaker, Sara C Zapico
When human remains are found, the priority of the investigation is to ascertain the identity of the deceased. A positive identification is a key factor in providing closure for the family of the deceased; it is also required to issue the death certificate and therefore, to settle legal affairs. Moreover, it is difficult for any forensic investigation involving human remains to be solved without the determination of an identity. Therefore, personal identification is necessary for social, legal and forensic reasons...
December 9, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/29240978/biomimicry-of-volatile-based-microbial-control-for-managing-emerging-fungal-pathogens
#5
REVIEW
Kyle T Gabriel, Joseph D Sexton, Christopher T Cornelison
Volatile organic compounds (VOCs) are known to be produced by a wide range of microorganisms and for a number of purposes. Volatile-based microbial inhibition in environments such as soil is well-founded, with numerous antimicrobial VOCs having been identified. Inhibitory VOCs are of interest as microbial control agents, as low concentrations of gaseous VOCs can elicit significant antimicrobial effects. Volatile organic compounds are organic chemicals typically characterized as having low molecular weight, low solubility in water, and high vapor pressure...
December 14, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29240827/diagnostic-accuracy-research-in-glaucoma-is-still-incompletely-reported-an-application-of-standards-for-reporting-of-diagnostic-accuracy-studies-stard-2015
#6
Manuele Michelessi, Ersilia Lucenteforte, Alba Miele, Francesco Oddone, Giada Crescioli, Valeria Fameli, Daniël A Korevaar, Gianni Virgili
BACKGROUND: Research has shown a modest adherence of diagnostic test accuracy (DTA) studies in glaucoma to the Standards for Reporting of Diagnostic Accuracy Studies (STARD). We have applied the updated 30-item STARD 2015 checklist to a set of studies included in a Cochrane DTA systematic review of imaging tools for diagnosing manifest glaucoma. METHODS: Three pairs of reviewers, including one senior reviewer who assessed all studies, independently checked the adherence of each study to STARD 2015...
2017: PloS One
https://www.readbyqxmd.com/read/29240793/dental-implants-in-sj%C3%A3-gren-s-syndrome-patients-a-systematic-review
#7
Daniel Almeida, Katia Vianna, Patrícia Arriaga, Vittorio Moraschini
OBJECTIVES: The Sjögren's syndrome (SS) is a chronic autoimmune disease that affects salivation and consequently the health of oral tissues. The aim of this systematic review was to investigate the implant survival rate, marginal bone loss (MBL) and biological complications of dental implants in SS patients. MATERIALS AND METHODS: Eligibility criteria included prospective and retrospective cohort studies, controlled clinical trials, and randomized clinical trials (RCTs)...
2017: PloS One
https://www.readbyqxmd.com/read/29239868/prolonged-preoperative-weakness-affects-recovery-of-motor-function-after-anterior-cervical-diskectomy-and-fusion
#8
Tyler Kreitz, Ronald Huang, David Beck, Andrew G Park, Alan Hilibrand
INTRODUCTION: Some patients who undergo anterior cervical diskectomy and fusion for radiculopathy or myelopathy demonstrate preoperative weakness. The purpose of this study was to determine which factors predict motor recovery in patients undergoing anterior cervical diskectomy and fusion. METHODS: A retrospective review of our institutional database identified patients undergoing anterior cervical diskectomy and fusion between 2010 and 2013 with 2 years of clinical follow-up...
December 8, 2017: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/29239024/concordance-between-administrative-data-and-clinical-review-for-mortality-in-the-randomized-on-off-bypass-follow-up-study-rooby-fs
#9
Jacquelyn A Quin, Brack Hattler, Annie Laurie W Shroyer, Darlene Kemp, G Hossein Almassi, Faisal G Bakaeen, Brendan M Carr, Muath Bishawi, Joseph F Collins, Frederick L Grover, Todd H Wagner
BACKGROUND: The optimal methodology to identify cardiac versus non-cardiac cause of death following cardiac surgery has not been determined. METHODS: The Randomized On/Off Bypass Trial was a multicenter, randomized, controlled clinical trial of 2203 patients (February 2002-May 2008) comparing 1-year cardiac outcomes between off-pump and on-pump bypass surgery. In 2013, the Veterans Affairs (VA) Cooperative Studies Program funded a follow-up study to assess 5-year outcomes including mortality...
December 13, 2017: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/29238948/antioxidants-for-preventing-and-reducing-muscle-soreness-after-exercise
#10
REVIEW
Mayur K Ranchordas, David Rogerson, Hora Soltani, Joseph T Costello
BACKGROUND: Muscle soreness typically occurs after intense exercise, unaccustomed exercise or actions that involve eccentric contractions where the muscle lengthens while under tension. It peaks between 24 and 72 hours after the initial bout of exercise. Many people take antioxidant supplements or antioxidant-enriched foods before and after exercise in the belief that these will prevent or reduce muscle soreness after exercise. OBJECTIVES: To assess the effects (benefits and harms) of antioxidant supplements and antioxidant-enriched foods for preventing and reducing the severity and duration of delayed onset muscle soreness following exercise...
December 14, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29238592/predictors-and-characteristics-of-angioectasias-in-patients-with-obscure-gastrointestinal-bleeding-identified-by-video-capsule-endoscopy
#11
Simon Nennstiel, Annkathrin Machanek, Stefan von Delius, Bruno Neu, Bernhard Haller, Mohamed Abdelhafez, Roland M Schmid, Christoph Schlag
Background: In obscure gastrointestinal bleeding, angioectasias are common findings in video capsule endoscopy (VCE). Objective: The objective of this study was to identify predictors and characteristics of small bowel angioectasias. Methods: Video capsule examinations between 1 July 2001 and 31 July 2011 were retrospectively reviewed. Patients with obscure gastrointestinal bleeding were identified, and those with small bowel angioectasia were compared with patients without a definite bleeding source...
December 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29238584/systematic-review-and-meta-analysis-of-the-performance-of-nurses-in-small-bowel-capsule-endoscopy-reading
#12
Diana E Yung, Ignacio Fernandez-Urien, Sarah Douglas, John N Plevris, Reena Sidhu, Mark E McAlindon, Simon Panter, Anastasios Koulaouzidis
Introduction: Increasing demands on healthcare systems mean that nurses are taking on more roles as physician extenders. Capsule endoscopy (CE) is a laborious procedure where specialist nurses could reduce physician workload and rationalise resource utilisation. The aim of this review and meta-analysis is to consolidate data on nurses' performance in small bowel CE (SBCE). Materials and methods: A comprehensive literature search was conducted for randomised controlled trials and comparative studies on nurses in SBCE reading compared to physicians...
December 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29238570/impact-of-asa-score-misclassification-on-nsqip-predicted-mortality-a-retrospective-analysis
#13
Alex Helkin, Sumeet V Jain, Angelika Gruessner, Maureen Fleming, Leslie Kohman, Michael Costanza, Robert N Cooney
Background: The ASA physical classification score has a major impact on the observed/expected (O/E) mortality ratio in the NSQIP General Vascular Mortality Model. The difference in predicted mortality is greatest between ASAs 3 and 4. We hypothesized under-classified ASA scores significantly affect the O/E mortality. Methods: We conducted a retrospective review of NSQIP essential surgery cases from January 2014 to December 2014 (n = 1264) with mortality sub-analysis (n = 33) at our institution...
2017: Perioperative Medicine
https://www.readbyqxmd.com/read/29238496/lifelong-learning-strategies-in-nursing-a-systematic-review
#14
REVIEW
Mojtaba Qanbari Qalehsari, Morteza Khaghanizadeh, Abbas Ebadi
Background: Lifelong learning is an expectation in the professional performance of nurses, which is directly related to the success of students in nursing schools. In spite of the considerable attention paid to this issue, lifelong learning strategies are not fully understood. Objective: The aim of this study was to clarify lifelong learning strategies of nursing students with respect to international experience. Methods: In this systematic review, an extensive investigation was carried out using Persian and English studies in Pub Med, ProQuest, Cochrane, Ovid, Scopus, Web of Science, SID, and Iran Doc using the following keywords: lifelong learning, self-directed learning, lifelong learning model, continuing education, nursing education, and lifelong program...
October 2017: Electronic Physician
https://www.readbyqxmd.com/read/29238448/a-systematic-review-of-research-studies-examining-telehealth-privacy-and-security-practices-used-by-healthcare-providers
#15
REVIEW
Valerie J M Watzlaf, Leming Zhou, Dilhari R Dealmeida, Linda M Hartman
The objective of this systematic review was to systematically review papers in the United States that examine current practices in privacy and security when telehealth technologies are used by healthcare providers. A literature search was conducted using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols (PRISMA-P). PubMed, CINAHL and INSPEC from 2003 - 2016 were searched and returned 25,404 papers (after duplications were removed). Inclusion and exclusion criteria were strictly followed to examine title, abstract, and full text for 21 published papers which reported on privacy and security practices used by healthcare providers using telehealth...
2017: International Journal of Telerehabilitation
https://www.readbyqxmd.com/read/29238357/structural-and-functional-diversity-of-plant-virus-3-cap-independent-translation-enhancers-3-cites
#16
REVIEW
Verónica Truniger, Manuel Miras, Miguel A Aranda
Most of the positive-strand RNA plant viruses lack the 5'-cap and/or the poly(A)-tail that act synergistically to stimulate canonical translation of cellular mRNAs. However, they have RNA elements in the 5'- or 3'-untranslated regions of their RNAs that are required for their cap-independent translation. Cap-independent translation enhancers (CITEs) have been identified in the genomic 3'-end of viruses belonging to the family Tombusviridae and the genus Luteovirus. Seven classes of 3'-CITEs have been described to date based on their different RNA structures...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29238323/relationship-between-hypothyroidism-and-non-alcoholic-fatty-liver-disease-a-systematic-review-and-meta-analysis
#17
Weiwei He, Xiaofei An, Ling Li, Xiaoqing Shao, Qian Li, Qiuming Yao, Jin-An Zhang
Background: Previous studies propose that hypothyroidism might play a crucial role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD), but findings from published studies on the relationship between hypothyroidism and NAFLD are still controversial. Our study aimed to make a comprehensive evaluation of the relationship between hypothyroidism and NAFLD through a meta-analysis. Methods: PubMed, China Dissertation Database, and EMBASE databases were searched to find observational studies assessing the relationship between hypothyroidism and NAFLD...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29238289/extracellular-tau-and-its-potential-role-in-the-propagation-of-tau-pathology
#18
REVIEW
Kaoru Yamada
The pathological aggregation of tau protein is a hallmark of a set of neurodegenerative diseases collectively referred to as tauopathies. Tau aggregates independently in each neuron, but this aggregation can also occur in a non-cell autonomous manner in which aggregated tau is transmitted from one cell to another. Such trans-cellular propagation is initiated by the uptake of extracellular tau, which then seeds soluble tau in the recipient cells to spread the tau pathology. Accumulating evidence has demonstrated that tau is not only present in the cytoplasm of neurons but also actively released into the extracellular space...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29238227/validation-of-asthma-recording-in-electronic-health-records-a-systematic-review
#19
REVIEW
Francis Nissen, Jennifer K Quint, Samantha Wilkinson, Hana Mullerova, Liam Smeeth, Ian J Douglas
Objective: To describe the methods used to validate asthma diagnoses in electronic health records and summarize the results of the validation studies. Background: Electronic health records are increasingly being used for research on asthma to inform health services and health policy. Validation of the recording of asthma diagnoses in electronic health records is essential to use these databases for credible epidemiological asthma research. Methods: We searched EMBASE and MEDLINE databases for studies that validated asthma diagnoses detected in electronic health records up to October 2016...
2017: Clinical Epidemiology
https://www.readbyqxmd.com/read/29238224/prognostic-value-of-cox-2-and-pd-l1-expression-and-its-relationship-with-tumor-infiltrating-lymphocytes-in-resected-lung-adenocarcinoma
#20
Katsuhiko Shimizu, Riki Okita, Shinsuke Saisho, Ai Maeda, Yuji Nojima, Masao Nakata
Programmed cell death-1 ligand 1 (PD-L1), tumor-infiltrating CD8-positive T lymphocytes (CD8-positive TILs), and cyclooxygenase-2 (Cox-2) have been used as prognostic tools in patients with lung adenocarcinoma. We conducted a retrospective review of data from 170 patients who had undergone pulmonary resection as an initial treatment for clinical T1-2 N0 lung adenocarcinoma. We then investigated the expressions of three biomarkers using immunohistochemical analyses and compared the expression levels with the clinicopathological characteristics and outcomes of the patients...
2017: Cancer Management and Research
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