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https://www.readbyqxmd.com/read/29789685/s100a4-protects-mice-from-high-fat-diet-induced-obesity-and-inflammation
#1
Shasha Hou, Ying Jiao, Qi Yuan, Junfeng Zhai, Tian Tian, Kaiji Sun, Zhinan Chen, Zhenlong Wu, Jinhua Zhang
As a member from S100 calcium-binding protein family, S100A4 is ubiquitous and elevated in tumor progression and metastasis, but its role in regulating obesity has not been well characterized. In this study, we showed that S100A4 was mainly expressed by stromal cells in adipose tissue and the S100A4 level in adipose tissue was decreased after high-fat diet (HFD). S100A4 deficient mice exhibited aggravated symptoms of obesity and suppressed insulin signaling after 12 weeks of HFD. Aggravated obesity in S100A4 deficient mice were found to be positively correlated with higher inflammatory status of the liver...
May 22, 2018: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/29758552/downregulation-of-s100a4-alleviates-cardiac-fibrosis-via-wnt-%C3%AE-catenin-pathway-in-mice
#2
LiJun Qian, Jian Hong, YanMei Zhang, MengLin Zhu, XinChun Wang, YanJuan Zhang, Ming Chu, Jing Yao, Di Xu
BACKGROUND/AIMS: Cardiac fibrosis is a pathological change leading to cardiac remodeling during the progression of myocardial ischemic diseases, and its therapeutic strategy remains to be explored. S100A4, a calcium-binding protein, participates in fibrotic diseases with an unclear mechanism. This study aimed to investigate the role of S100A4 in cardiac fibrosis. METHODS: Cardiac fibroblasts from neonatal C57BL/6 mouse hearts were isolated and cultured. Myocardial infarction was induced by ligating the left anterior descending coronary artery (LAD)...
May 7, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29742762/advantages-of-molecular-weight-identification-during-native-ms-screening
#3
Ahad Khan, Anne Bresnick, Sean Cahill, Mark Girvin, Steve Almo, Ronald Quinn
Native mass spectrometry detection of ligand-protein complexes allowed rapid detection of natural product binders of apo and calcium-bound S100A4 (a member of the metal binding protein S100 family), T cell/transmembrane, immunoglobulin (Ig), and mucin protein 3, and T cell immunoreceptor with Ig and ITIM (immunoreceptor tyrosine-based inhibitory motif) domains precursor protein from extracts and fractions. Based on molecular weight common hits were detected binding to all four proteins. Seven common hits were identified as apigenin 6- C - β - D -glucoside 8- C - α - L -arabinoside, sweroside, 4',5-dihydroxy-7-methoxyflavanone-6- C -rutinoside, loganin acid, 6- C -glucosylnaringenin, biochanin A 7- O -rutinoside and quercetin 3- O -rutinoside...
May 9, 2018: Planta Medica
https://www.readbyqxmd.com/read/29741811/basal-like-breast-cancer-engages-tumor-supportive-macrophages-via-secreted-factors-induced-by-extracellular-s100a4
#4
Lina Prasmickaite, Ellen M Tenstad, Solveig Pettersen, Shakila Jabeen, Eivind Valen Egeland, Silje Nord, Abhilash Pandya, Mads Haugland Haugen, Vessela N Kristensen, Anne-Lise Børresen-Dale, Olav Engebråten, Gunhild M Maelandsmo
The tumor microenvironment (TME) may influence both cancer progression and therapeutic response. In breast cancer (BC), particularly in the aggressive triple-negative/basal-like subgroup, patient outcome is strongly associated with the tumor's inflammatory profile. Tumor-associated macrophages (TAMs) are among the most abundant immune cells in the TME, shown to be linked to poor prognosis and therapeutic resistance. In this study we investigated the effect of the metastasis- and inflammation-associated microenvironmental factor S100A4 on breast cancer cells (BCCs) of different subtypes, and explored their further interactions with myeloid cells...
May 9, 2018: Molecular Oncology
https://www.readbyqxmd.com/read/29733962/extracellular-atp-drives-breast-cancer-cell-migration-and-metastasis-via-s100a4-production-by-cancer-cells-and-fibroblasts
#5
Ying Liu, Yue-Hang Geng, Hui Yang, Han Yang, Yan-Ting Zhou, Hong-Quan Zhang, Xin-Xia Tian, Wei-Gang Fang
Our previous work has demonstrated that extracellular ATP is an important pro-invasive factor, and in this study, we tapped into a possible mechanism involved. We discovered that ATP could upregulate both the intracellular expression and secretion of S100A4 in breast cancer cells and fibroblasts. Apart from stimulating breast cancer cell motility via intracellular S100A4, ATP enhanced the ability of breast cancer cells to transform fibroblasts into cancer-associated fibroblast (CAF)-like cells, which in turn secreted S100A4 to further promote cancer cell motility...
May 5, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29720235/effects-of-selexipag-and-its-active-metabolite-in-contrasting-the-profibrotic-myofibroblast-activity-in-cultured-scleroderma-skin-fibroblasts
#6
Maurizio Cutolo, Barbara Ruaro, Paola Montagna, Renata Brizzolara, Emanuela Stratta, Amelia Chiara Trombetta, Stefano Scabini, Pier Paolo Tavilla, Aurora Parodi, Claudio Corallo, Nicola Giordano, Sabrina Paolino, Carmen Pizzorni, Alberto Sulli, Vanessa Smith, Stefano Soldano
BACKGROUND: Myofibroblasts contribute to fibrosis through the overproduction of extracellular matrix (ECM) proteins, primarily type I collagen (COL-1) and fibronectin (FN), a process which is mediated in systemic sclerosis (SSc) by the activation of fibrogenic intracellular signaling transduction molecules, including extracellular signal-regulated kinases 1 and 2 (Erk1/2) and protein kinase B (Akt). Selexipag is a prostacyclin receptor agonist synthesized for the treatment of pulmonary arterial hypertension...
May 2, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29679610/mutated-mitf-e87r-in-melanoma-enhances-tumor-progression-via-s100a4
#7
Alice Nordlinger, Shani Dror, Abdel Elkahloun, Justine Del Rio, Elisa Stubbs, Tami Golan, Hagar Malcov, Todd D Pricket, Julia C Cronin, Shivang Parikh, Sapir Labes, Laetitia Thomas, Gal Yankovitz, Yuval Tabach, Carmit Levy, Yardena Samuels, Mehdi Khaled
Melanoma, a melanocyte origin neoplasm, is the most lethal type of skin cancer and incidence is increasing. Several familial and somatic mutations have been identified in the gene encoding the melanocyte lineage master regulator, microphthalmia-associated transcription factor (MITF); however, the neoplastic mechanisms of these mutant MITF variants are mostly unknown. Here, by performing unbiased analysis of the transcriptomes in cells expressing mutant MITF, we identified calcium-binding protein S100A4, as a downstream target of MITF-E87R...
April 18, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29660231/plakoglobin-restores-tumor-suppressor-activity-of-p53-r175h-mutant-by-sequestering-the-oncogenic-potential-of-%C3%AE-catenin
#8
Mahsa Alaee, Kristina Nool, Manijeh Pasdar
The tumor suppressor/transcription factor p53 is mutated in over 50% of all cancers. Some mutant p53 proteins not only have lost tumor suppressor activities but they also gain oncogenic functions (GOF). One of the most frequently expressed GOF p53 mutants is Arg175His (p53R175H ) with well-documented roles in cancer development and progression. Plakoglobin is a cell adhesion and signalling protein and a paralog of β-catenin. Unlike β-catenin that has oncogenic function via its role in Wnt pathway, plakoglobin generally acts as a tumor/metastasis suppressor...
April 16, 2018: Cancer Science
https://www.readbyqxmd.com/read/29578167/overexpression-of-s100a4-protein-may-be-associated-with-the-development-and-progression-of-pancreatic-cancer
#9
Yong Zhou, Zhaohua Li, Yinlu Ding, Jianxin Zhang, Qifeng Yang, Yuezhen Wu
Aim: Accumulated evidence has suggested a relationship between S100A4 protein expression and the development and progression of pancreatic cancer (PC) while its role in diagnosis and prognosis of PC still keeps inconsistent. To obtain definitive associations between S100A4 and PC, a meta-analysis was conducted. Materials and Methods: The PubMed and Chinese National Knowledge Infrastructure databases were electronically searched to identify studies reporting an association between S100A4 protein and PC...
2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29567857/targeting-brain-adaptive-cancer-stem-cells-prohibits-brain-metastatic-colonization-of-triple-negative-breast-cancer
#10
Ding Ren, Xiaoping Zhu, Ren Kong, Zhen Zhao, Jianting Sheng, Jiang Wang, Xiaoyun Xu, Jiyong Liu, Kemi Cui, Xiang H-F Zhang, Hong Zhao, Stephen T C Wong
Triple-negative breast cancer (TNBC) exhibits more traits possessed by cancer stem cells (CSC) than other breast cancer subtypes and is more likely to develop brain metastases. TNBC patients usually have shorter survival time after diagnosis of brain metastasis, suggesting an innate ability of TNBC tumor cells in adapting to the brain. In this study, we establish novel animal models to investigate early tumor adaptation in brain metastases by introducing both patient-derived and cell line-derived CSC-enriched brain metastasis tumorsphere cells into mice...
April 15, 2018: Cancer Research
https://www.readbyqxmd.com/read/29556233/s100a4-protects-myeloid-derived-suppressor-cells-from-intrinsic-apoptosis-via-tlr4-erk1-2-signaling
#11
Qingcui Li, Chengliang Dai, Rui Xue, Peigang Wang, Lin Chen, Yijie Han, Ulrike Erben, Zhihai Qin
Myeloid-derived suppressor cells (MDSCs) often expand during cancer or chronic inflammation and dampen immune responses. However, mechanisms underlying their capacity to escape intrinsic apoptosis in the inflammatory environment are still largely unknown. In this study, we investigated this in mouse tumor models with MDSC accumulation. Spontaneous rejection of tumors implanted into mice deficient for the small Ca2+ -binding protein S100A4 (S100A4-/- ) was accompanied by low numbers of peripheral MDSCs. This was independent of S100A4 expression on tumor cells...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29555579/analysis-of-cancer-associated-fibroblasts-and-the-epithelial-mesenchymal-transition-in-cutaneous-basal-cell-carcinoma-squamous-cell-carcinoma-and-malignant-melanoma
#12
Kousuke Sasaki, Tamotsu Sugai, Kazuyuki Ishida, Mitsumasa Osakabe, Hiroo Amano, Hiroaki Kimura, Minoru Sakuraba, Katsuhiko Kashiwa, Seiichiro Kobayashi
Activated cancer-associated fibroblasts (CAFs) and fibroblasts that have undergone the epithelial-mesenchymal transition (EMT) in cancer stroma contribute to tumor progression and metastasis. However, no reports have investigated the CAF phenotype and its clinicopathological relevance in cutaneous malignant tumors, including basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and malignant melanoma (MM). Here, we investigated the CAF phenotype in cutaneous malignant tumors based on their histology and immunohistochemical expression of CAF-related markers, including adipocyte enhancer-binding protein 1 (AEBP1), podoplanin, platelet derived growth factor receptor α (PDGFRα), PDGFRβ, fibroblast activating protein (FAP), CD10, S100A4, α-smooth muscle actin (α-SMA), and EMT-related markers (Zeb1, Slug and Twist)...
March 16, 2018: Human Pathology
https://www.readbyqxmd.com/read/29510695/cd133-expression-in-cancer-cells-predicts-poor-prognosis-of-non-mucin-producing-intrahepatic-cholangiocarcinoma
#13
Xiaobo Cai, Jun Li, Xiaodong Yuan, Jingbo Xiao, Steven Dooley, Xinjian Wan, Honglei Weng, Lungen Lu
BACKGROUND: CD133 is a marker of stem cells as well cancer stem cells. This study investigated the association between CD133 expression in cancer cells and the clinical outcome of non-mucin producing intrahepatic cholangiocarcinoma (ICC). METHODS: Fifty-seven non-mucin producing ICC patients were enrolled in this study. Immunohistochemistry (IHC) and immunofluorescence staining for CD133 as well as other cancer-associated proteins, including cytokeratin 19, TGF-β1, p-Smad2 and epithelial-mesenchymal transition (EMT) markers S100A4, E-Cadherin and Vimentin were analyzed...
March 6, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29497991/cancer-associated-fibroblasts-affect-breast-cancer-cell-gene-expression-invasion-and-angiogenesis
#14
Noemi Eiro, Lucía González, Anxo Martínez-Ordoñez, Belen Fernandez-Garcia, Luis O González, Sandra Cid, Francisco Dominguez, Román Perez-Fernandez, Francisco J Vizoso
PURPOSE: It has been reported that stromal cell features may affect the clinical outcome of breast cancer patients. Cancer associated fibroblasts (CAFs) represent one of the most abundant cell types within the breast cancer stroma. Here, we aimed to explore the influence of CAFs on breast cancer gene expression, as well as on invasion and angiogenesis. METHODS: qRT-PCR was used to evaluate the expression of several cancer progression related genes (S100A4, TGFβ, FGF2, FGF7, PDGFA, PDGFB, VEGFA, IL-6, IL-8, uPA, MMP2, MMP9, MMP11 and TIMP1) in the human breast cancer-derived cell lines MCF-7 and MDA-MB-231, before and after co-culture with CAFs...
March 1, 2018: Cellular Oncology (Dordrecht)
https://www.readbyqxmd.com/read/29453969/s100-proteins-in-oral-squamous-cell-carcinoma
#15
REVIEW
Muhammad Arsalan Raffat, Naila Irum Hadi, Mervyn Hosein, Sana Mirza, Sana Ikram, Zohaib Akram
BACKGROUND: Controversy exists in the literature regarding the differential expression of S100 protein members and their functional correlations in oral squamous cell carcinoma (OSCC). The aim of the present study was to systematically review the expression of S100 protein family members among OSCC and healthy controls and to evaluate whether S100 protein members serve as diagnostic marker in OSCC. METHODS: Indexed databases were searched up to and including October 2017...
May 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29453465/screening-of-potential-adipokines-identifies-s100a4-as-a-marker-of-pernicious-adipose-tissue-and-insulin-resistance
#16
Peter Arner, Paul Petrus, David Esteve, Anne Boulomié, Erik Näslund, Anders Thorell, Hui Gao, Ingrid Dahlman, Mikael Rydén
BACKGROUND: Adipokines are peptides secreted from white adipose tissue (WAT), which have been linked to WAT dysfunction and metabolic complications of obesity. We set out to identify novel adipokines in subcutaneous WAT (sWAT) linked to insulin resistance (IR). METHODS: Gene expression was determined by microarray and qPCR in obese and non-obese subjects with varying degree of IR. WAT-secreted and circulating protein levels were measured by ELISA. RESULTS: In sWAT of 80 obese women discordant for IR, 44 genes encoding potential adipose-secreted proteins were differentially expressed...
January 30, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29449540/s100a4-promotes-lung-tumor-development-through-%C3%AE-catenin-pathway-mediated-autophagy-inhibition
#17
Shasha Hou, Tian Tian, Dianwen Qi, Kaiji Sun, Qi Yuan, Ziling Wang, Zhihai Qin, Zhenlong Wu, Zhinan Chen, Jinhua Zhang
Autophagy has emerged as a critical pathway in tumor development. S100A4 plays important roles in tumor metastasis, but its role in regulating autophagy has not been well characterized. In this study, we found that S100A4 was significantly upregulated in lung adenocarcinoma tissues. Clinical investigation demonstrated that high expression level of S100A4 was associated with tumor size and advanced tumor grades of lung adenocarcinoma patients. Moreover, our results revealed that extracellular S100A4 or overexpression of S100A4 inhibited starvation-induced autophagy and promoted cell proliferation in lung cancer cells in vitro; whereas small interfering RNA (siRNA)-mediated suppression of S100A4 increased autophagy and reduced cell viability in both A549 and LLC cells...
February 15, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29445087/rage-induces-hepatocellular-carcinoma-proliferation-and-sorafenib-resistance-by-modulating-autophagy
#18
Jun Li, Peng-Wen Wu, Yuan Zhou, Bo Dai, Peng-Fei Zhang, Yu-Hen Zhang, Yang Liu, Xiao-Lei Shi
The receptor for advanced glycation end products (Rage) is involved in the development of various tumors and acts as an oncogenic protein. Rage is overexpressed in tumors including hepatocellular carcinoma (HCC). However, the molecular mechanism of Rage in HCC progression and sorafenib resistance remains unclear. In this study, enhanced Rage expression is highly associated proliferation and contributes to sorafenib resistance. Rage deficiency contributed to autophagy induction through activating AMPK/mTOR signaling pathway, which is important for sorafenib response...
February 14, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29421955/serum-s100-calcium-binding-protein-a4-s100a4-metatasin-as-a-diagnostic-and-prognostic-biomarker-in-epithelial-ovarian-cancer
#19
Y Lv, Z Niu, X Guo, F Yuan, Y Liu
No abstract text is available yet for this article.
April 2018: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/29400663/clusterin-promotes-growth-and-invasion-of-clear-cell-renal-carcinoma-cell-by-upregulation-of-s100a4-expression
#20
Yuan Liu, Changping Men, Yingmin Xu, Kai Zhao, Lei Luo, Dahai Dong, Qinchao Yu
BACKGROUND AND OBJECTIVE: Clusterin promotes cell proliferation, motility and invasiveness in human renal cell carcinoma (RCC) cells but the underlying molecular mechanisms of this action are largely unknown. The aim of this study was to investigate the effects of clusterin on cancer cell growth, invasion and S100A4 expression and to determine the effects of clusterin on in vitro cell proliferation and migration and in vivo tumour growth in RCC cells. METHODS: We have established stable transfectants of highly invasive Caki-1 human RCC cells with expression of clusterin shRNA targeting clusterin (Caki-1/clusterin shRNA)...
2018: Cancer Biomarkers: Section A of Disease Markers
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