keyword
https://read.qxmd.com/read/38509414/resistance-exercise-minimal-dose-strategies-for-increasing-muscle-strength-in-the-general-population-an-overview
#21
REVIEW
James L Nuzzo, Matheus D Pinto, Benjamin J C Kirk, Kazunori Nosaka
Many individuals do not participate in resistance exercise, with perceived lack of time being a key barrier. Minimal dose strategies, which generally reduce weekly exercise volumes to less than recommended guidelines, might improve muscle strength with minimal time investment. However, minimal dose strategies and their effects on muscle strength are still unclear. Here our aims are to define and characterize minimal dose resistance exercise strategies and summarize their effects on muscle strength in individuals who are not currently engaged in resistance exercise...
March 20, 2024: Sports Medicine
https://read.qxmd.com/read/38509128/epigenetic-modulators-link-mitochondrial-redox-homeostasis-to-cardiac-function-in-a-sex-dependent-manner
#22
JOURNAL ARTICLE
Zaher ElBeck, Mohammad Bakhtiar Hossain, Humam Siga, Nikolay Oskolkov, Fredrik Karlsson, Julia Lindgren, Anna Walentinsson, Dominique Koppenhöfer, Rebecca Jarvis, Roland Bürli, Tanguy Jamier, Elske Franssen, Mike Firth, Andrea Degasperi, Claus Bendtsen, Robert I Menzies, Katrin Streckfuss-Bömeke, Michael Kohlhaas, Alexander G Nickel, Lars H Lund, Christoph Maack, Ákos Végvári, Christer Betsholtz
While excessive production of reactive oxygen species (ROS) is a characteristic hallmark of numerous diseases, clinical approaches that ameliorate oxidative stress have been unsuccessful. Here, utilizing multi-omics, we demonstrate that in cardiomyocytes, mitochondrial isocitrate dehydrogenase (IDH2) constitutes a major antioxidative defense mechanism. Paradoxically reduced expression of IDH2 associated with ventricular eccentric hypertrophy is counterbalanced by an increase in the enzyme activity. We unveil redox-dependent sex dimorphism, and extensive mutual regulation of the antioxidative activities of IDH2 and NRF2 by a feedforward network that involves 2-oxoglutarate and L-2-hydroxyglutarate and mediated in part through unconventional hydroxy-methylation of cytosine residues present in introns...
March 20, 2024: Nature Communications
https://read.qxmd.com/read/38507938/atypical-teratoid-rhabdoid-tumor-of-the-central-nervous-system-clinicopathological-features-of-two-challenging-cases
#23
Sawsan Ismail, Lina Ghanem, Leen Ibrahim, Mohammed Abdulrahman, Zuheir Alshehabi, Rana Issa
INTRODUCTION: Atypical Teratoid/Rhabdoid Tumor (AT/RT) is a rare aggressive neoplasm that mainly affects the pediatric population with a peak incidence in the first two years of life and a slight male predominance, whereas presentation of this neoplasm in older ages is extremely rare. CASE PRESENTATION: Herein, we present two cases of AT/RT. In the first case, a 9-year-old female presented with diplopia, dizziness, headache, and morning vomiting. CT Scan of the head demonstrated a heterogeneous mass in the left frontal-parietal region with vasogenic edema and midline deviation...
March 19, 2024: International Journal of Surgery Case Reports
https://read.qxmd.com/read/38507234/effects-of-eccentric-strength-training-on-motor-function-in-individuals-with-stroke-a-scoping-review
#24
REVIEW
Natalia Perez, Cristian Morales, Alvaro Reyes, Travis Cruickshank, Luis Penailillo
BACKGROUND: Preliminary evidence suggests that eccentric strength training (ECC) improves muscle strength and postural control in individuals with stroke; however, the evidence about the effects of ECC in people living with stroke has not been systematically analyzed. OBJECTIVE: To determine the effects of ECC, compared to other exercise modalities (i.e., concentric training), on motor function in individuals with stroke. METHODS: This scoping review was performed according to PRISMA extension for scoping reviews...
March 20, 2024: Topics in Stroke Rehabilitation
https://read.qxmd.com/read/38505736/theoretical-and-experimental-study-of-attenuation-in-cancellous-bone
#25
JOURNAL ARTICLE
Wenyi Xu, Weiya Xie, Dong Yu, Haohan Sun, Ying Gu, Xingliang Tao, Menglu Qian, Liming Cheng, Hao Wang, Qian Cheng
SIGNIFICANCE: Photoacoustic (PA) technology shows great potential for bone assessment. However, the PA signals in cancellous bone are complex due to its complex composition and porous structure, making such signals challenging to apply directly in bone analysis. AIM: We introduce a photoacoustic differential attenuation spectrum (PA-DAS) method to separate the contribution of the acoustic propagation path to the PA signal from that of the source, and theoretically and experimentally investigate the propagation attenuation characteristics of cancellous bone...
January 2024: Journal of Biomedical Optics
https://read.qxmd.com/read/38502110/normative-standards-for-isokinetic-and-anthropometric-classifications-of-university-level-netball-players
#26
JOURNAL ARTICLE
Kyra-Kezzia Duvenage, Yolandi Willemse, Hans de Ridder, Mark Kramer
CONTEXT: The purpose of the study was to develop normative ranges and standards for knee and shoulder isokinetic and anthropometric values. These standards can be qualitatively interpreted and allow practitioners to classify isokinetic and anthropometric values more objectively for university-level netball players. DESIGN: Posttest only observational study design. All players were only evaluated once during the in-season to generate normative ranges. METHODS: A total of 51 female players volunteered...
March 18, 2024: Journal of Sport Rehabilitation
https://read.qxmd.com/read/38495194/new-beam-based-models-for-fire-induced-buckling-analysis-of-class-4-steel-columns
#27
JOURNAL ARTICLE
Myriam R Pallares-Muñoz, Ignacio Paya-Zaforteza, Antonio Hospitaler-Perez
Steel cross-sections with thin walls are vulnerable to fire-induced buckling instability, which reduces their load-bearing capacity. Eurocode 3 design provisions have been found inadequate, leading to alternative methods such as effective design strategies and advanced structural models built mostly with shell FE, which can be complex. For Class 4 steel beam-columns subjected to fire conditions, beam-type modelling to predict the Flexural-Torsional Buckling (FTB) strength has been proposed as an alternative approach, but it has not yielded satisfactory results for large compressive load eccentricities...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38495148/structural-performance-of-detachable-precast-concrete-column-column-joint
#28
JOURNAL ARTICLE
H Zhan, M Ye, J Jiang, Y Gao, C W Zheng, S C Duan
A novel type of detachable precast concrete column-column joint (DPC) is proposed in this study to solve the problems in current column-column dry connections including complex load path, uncertainty of structural stiffness of beam-column joints and inconvenience for disassembly. The dry connection technology is applied by composing of steel plate and concrete. Finite element models of DPC were created to study its structural performance including hysteresis curve, skeleton curve, ductility, and energy dissipation capacity...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38494447/intrasession-repeatability-and-agreement-of-the-anterior-corneal-assessment-provided-by-a-multidiagnostic-device
#29
JOURNAL ARTICLE
Ana Rosa Barrio, Beatriz Antona, Sofía Morago-Villanueva, Víctor Martínez-Arribas, Mariano González-Pérez
CLINICAL RELEVANCE: Multidiagnostic systems have recently appeared on the market. Knowledge of the repeatability and validity of any instrument is mandatory before its introduction in clinical practice. BACKGROUND: The aim of this work is to examine the intrasession repeatability of anterior pole measurements provided by the multidiagnostic device Wave Analyzer Medica 700 (WAM700) and agreement with Pentacam measurements in normal eyes. METHODS: In the right eyes of 113 participants, three repeat measurements of central keratometry, central corneal thickness, anterior chamber depth and corneal eccentricity were made with the WAM700 and Pentacam in random order...
March 17, 2024: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://read.qxmd.com/read/38493954/proteomic-profiling-of-muscular-adaptations-to-short-term-concentric-vs-eccentric-exercise-training-in-humans
#30
JOURNAL ARTICLE
Jiawei Du, Hezhang Yun, Hongsheng Wang, Xin Bai, Yuhui Su, Xiaochuan Ge, Yang Wang, Boya Gu, Li Zhao, Ji-Guo Yu, Yafeng Song
The molecular mechanisms underlying muscular adaptations to concentric, and eccentric exercise training have been extensively explored. However, most previous studies have focused on subjectively selected proteins, thus, unable to provide a comprehensive protein profile, and potentially missing the crucial mechanisms underlying muscular adaptation to exercise training. We herein aimed to investigate proteomic profiles of human skeletal muscle in response to short-term resistance training. Twenty young males were randomly and evenly assigned to two groups to complete a four-week either eccentric (ECC) or concentric (CON) training program...
March 15, 2024: Molecular & Cellular Proteomics: MCP
https://read.qxmd.com/read/38493525/investigating-balance-related-gait-patterns-and-their-relationship-with-maximum-torques-generated-by-the-hamstrings-and-quadriceps-in-older-adults-results-from-the-baltimore-longitudinal-study-of-aging
#31
JOURNAL ARTICLE
Seung-Uk Ko, Gerald J Jerome, Eleanor M Simonsick, Luigi Ferrucci
BACKGROUND: Balance-related gait patterns in older adults can be objectively discerned through the examination of gait parameters, maximum leg torques, and their interconnections. OBJECTIVE: To investigate the correlation between leg muscle strength and balance during gait concerning functional performance in healthy older adults. METHODS: Participants included 117 adults aged 60-95 years were recruited from the Baltimore Longitudinal Study of Aging (BLSA)...
March 12, 2024: Archives of Gerontology and Geriatrics
https://read.qxmd.com/read/38489637/spin-frame-field-theory-of-a-three-sublattice-antiferromagnet
#32
JOURNAL ARTICLE
Bastián Pradenas, Oleg Tchernyshyov
We present a nonlinear field theory of a three-sublattice hexagonal antiferromagnet. The order parameter is the spin frame, an orthogonal triplet of vectors related to sublattice magnetizations and spin chirality. The exchange energy, quadratic in spin-frame gradients, has three coupling constants, only two of which manifest themselves in the bulk. As a result, the three spin-wave velocities satisfy a universal relation. Vortices generally have an elliptical shape with the eccentricity determined by the Lamé parameters...
March 1, 2024: Physical Review Letters
https://read.qxmd.com/read/38487870/left-atrial-shape-as-a-marker-of-atrial-myopathy-in-embolic-stroke-of-undetermined-source
#33
JOURNAL ARTICLE
Aaisha Ferkh, Kasun De Silva, Jennifer Pham, Luke Stefani, Karen Byth, Amy Clark, Siddharth J Trivedi, Sai Nagaratnam, Andrew Duggins, Eddy Kizana, Aravinda Thiagalingam, Liza Thomas
AIMS: Embolic Stroke of Undetermined Source (ESUS) results in significant morbidity. A left atrial (LA) myopathy is implicated in a proportion of these patients. We hypothesized that LA shape varies by cause of stroke (cardioembolic versus ESUS). METHODS AND RESULTS: 236 ischemic stroke, atrial fibrillation (AF) patients and controls were recruited prospectively. AF was classified as paroxysmal (PAF) or persistent AF (PersAF). Stroke patients comprised cardioembolic stroke (CE) secondary to AF and ESUS...
March 15, 2024: European Heart Journal Cardiovascular Imaging
https://read.qxmd.com/read/38484285/assessing-the-reliability-of-biomechanical-variables-during-a-horizontal-deceleration-task-in-healthy-adults
#34
JOURNAL ARTICLE
Joshua Cross, Stacey M Kung, Neil Welch
Horizontal deceleration technique is an underpinning factor to musculoskeletal injury risk and performance in multidirectional sport. This study primarily assessed within- and between-session reliability of biomechanical and performance-based aspects of a horizontal deceleration technique and secondarily investigated the effects of limb dominance on reliability. Fifteen participants completed four horizontal decelerations on each leg during test and retest sessions. A three-dimensional motion analysis system was used to collect kinetic and kinematic data...
March 14, 2024: Journal of Sports Sciences
https://read.qxmd.com/read/38484106/longitudinal-adaptive-optics-scanning-laser-ophthalmoscopy-reveals-regional-variation-in-cone-and-rod-photoreceptor-loss-in-stargardt-disease
#35
JOURNAL ARTICLE
Hongxin Song, Hui Hang, Kaiwen Li, Ethan A Rossi, Jie Zhang
PURPOSE: To investigate the temporal sequence of changes in the photoreceptor cell mosaic in patients with Stargardt disease type 1 (STGD1), using adaptive optics scanning laser ophthalmoscopy (AOSLO). METHODS: Two brothers with genetically confirmed STGD1 underwent comprehensive eye exams, spectral-domain optical coherence tomography (SD-OCT), fundus auto fluorescence (FAF) and AOSLO imaging 3 times over the course of 28 months. Confocal images of the cones and rods were obtained from the central fovea to 10 degrees inferiorly...
March 13, 2024: Retina
https://read.qxmd.com/read/38483610/comparing-2-dimensional-macular-pigment-optical-density-with-objective-and-subjective-perimetry-and-visual-acuity-in-age-related-macular-degeneration
#36
JOURNAL ARTICLE
Bhim B Rai, Faran Sabeti, Joshua P van Kleef, Corinne F Carle, Emilie M F Rohan, Rohan W Essex, Richard C Barry, Ted Maddess
PURPOSE: To compare diagnostic power for different severities of age-related macular degeneration (AMD) of two-dimensional macular pigment optical densities (2D-MPOD) and spatially matched objective perimetry, with standard perimetry and best-corrected visual acuity (BCVA). METHODS: The ObjectiveField Analyser (OFA) provided objective perimetry, and a Heidelberg Spectralis optical coherence tomography (OCT) measured 2D-MPOD in AMD patients, both completed twice over 0...
March 14, 2024: Graefe's Archive for Clinical and Experimental Ophthalmology
https://read.qxmd.com/read/38483553/-endocarditis-and-ischemic-stroke-of-rare-cause
#37
JOURNAL ARTICLE
L Schönfeld, G Scheumann, J Jöckel
A 60-year-old male patient presented with ischemic-embolic stroke. Transesophageal echocardiography revealed the cause to be aortic valve endocarditis with highly eccentric aortic valve regurgitation. The blood cultures taken several times remained sterile. The indication for surgical aortic valve replacement was made. Conventional microbiological work-up of the heart valve did not reveal any pathogens. The additional molecular genetic testing using eubacterial PCR ("polymerase chain reaction" [PCR]) finally demonstrated the presence of Tropheryma whipplei...
March 14, 2024: Inn Med (Heidelb)
https://read.qxmd.com/read/38482578/eccentric-exercise-%C3%A2-eccentric-contraction
#38
JOURNAL ARTICLE
Paolo Tecchio, Brent J Raiteri, Daniel Hahn
Whether eccentric exercise involves active fascicle stretch is unclear due to muscle-tendon unit (MTU) series elasticity. Therefore, this study investigated the impact of changing the activation timing and level (i.e., pre-activation) of the contraction on muscle fascicle kinematics and kinetics of the human tibialis anterior during dynamometer-controlled maximal voluntary MTU-stretch-hold contractions. B-mode ultrasound and surface electromyography were employed to assess muscle fascicle kinematics and muscle activity levels, respectively...
March 14, 2024: Journal of Applied Physiology
https://read.qxmd.com/read/38481639/wire-bias-modification-with-reverse-orbital-atherectomy-for-safer-rotational-atherectomy-in-calcified-bifurcation
#39
Toshimasa Oda, Yoshihisa Kinoshita, Masatoshi Miyahara, Yuichiro Maekawa, Hideo Nishikawa, Takahiko Suzuki
UNLABELLED: Although debulking devices are very useful in modifying calcified plaques, their effectiveness is highly dependent on wire bias. In particular, in eccentric calcified bifurcation lesions, wire bias tends to be poor and needs to be corrected for adequate lesion preparation. A 67-year-old man was diagnosed with exertional angina pectoris. Coronary angiography showed a highly calcified eccentric lesion from the left main trunk to the left anterior descending artery. The patient refused coronary artery bypass surgery, therefore we decided to treat this complex bifurcation lesion with percutaneous coronary intervention...
March 2024: Journal of Cardiology Cases
https://read.qxmd.com/read/38478760/adaptive-optics-imaging-in-diabetic-retinopathy-a-prospective-cohort-study
#40
JOURNAL ARTICLE
Michael Balas, Mariam Issa, Marko M Popovic, Lana Moayad, Chris Zajner, Paola Oquendo Aponte, Hesham Hamli, Peng Yan, Tom Wright, Isabela M Melo, Rajeev H Muni
PURPOSE: To investigate the correlation between diabetic retinopathy (DR) severity and microscopic retinal and vascular alterations using adaptive optics imaging (AOI). METHODS: In this single-center, prospective cohort study, adult participants with healthy eyes or DR underwent AOI. Participants were classified into control/mild non-proliferative DR (NPDR), moderate/severe NPDR, and proliferative DR. AOI using the RTX1 camera was obtained from 48 participants (87 eyes) for photoreceptor data, and from 36 participants (62 eyes) for vascular data...
March 12, 2024: Retina
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