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https://www.readbyqxmd.com/read/28194062/performance-of-galactomannan-antigen-beta-d-glucan-and-aspergillus-lateral-flow-device-for-the-diagnosis-of-invasive-aspergillosis
#1
Gökhan Metan, Muzaffer Keklik, Gökçen Dinç, Çiğdem Pala, Afra Yıldırım, Berkay Saraymen, Mustafa Yavuz Köker, Leylagül Kaynar, Bülent Eser, Mustafa Çetin
Aspergillus lateral-flow device (LFD) was recently introduced as a practical tool for the diagnosis of invasive aspergillosis (IA). We investigated the performance of Aspergillus-LFD as a point-of-care test for the diagnosis of IA. Serum samples were collected twice weekly from patients who received intensive chemotherapy for acute leukemia, or recepients of allogeneic stem cell transplantation. Aspergillus galactomannan (GM) antigen, 1,3-beta-d-glucan and Aspergillus-LFD tests were carried out according to manufacturers' recommendations...
March 2017: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/28188094/catheter-related-bloodstream-infection-caused-by-kodamaea-ohmeri-a-case-report-and-literature-review
#2
Yoshiaki Kanno, Yoshitaka Wakabayashi, Mahoko Ikeda, Keita Tatsuno, Yoshiki Misawa, Tomoaki Sato, Shintaro Yanagimoto, Shu Okugawa, Kyoji Moriya, Hiroshi Yotsuyanagi
Kodamaea ohmeri is a rare yeast pathogen that has recently emerged as an important cause of fungemia in immunocompromised patients. However, appropriate therapy for this infection remains unclear. We report a case of catheter-related blood stream infection caused by K. ohmeri in a 58-year-old patient who improved after removal of the central venous catheter and administration of micafungin. Considering the antibiotic susceptibility of this pathogen and reviewing literature, echinocandins may be the first choice for an empiric therapy for this pathogen...
February 7, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28188052/-saccharomyces-cerevisiae-invasive-infection-the-first-reported-case-in-morocco
#3
A Maleb, E Sebbar, M Frikh, S Boubker, A Moussaoui, A El Mekkaoui, W Khannoussi, G Kharrasse, B Belefquih, A Lemnouer, Z Ismaili, M Elouennass
Saccharomyces cerevisiae is a cosmopolitan yeast, widely used in agro-alimentary and pharmaceutical industry. Its impact in human pathology is rare, but maybe still underestimated compared to the real situation. This yeast is currently considered as an emerging and opportunistic pathogen. Risk factors are immunosuppression and intravascular device carrying. Fungemias are the most frequent clinical forms. We report the first case of S. cerevisiae invasive infection described in Morocco, and to propose a review of the literature cases of S...
February 7, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/28148470/diagnostic-accuracy-of-interleukin-6-interleukin-8-and-interleukin-10-for-predicting-bacteremia-in-children-with-febrile-neutropenia
#4
Zümrüt Şahbudak Bal, Nihal Karadaş Özdemir, Semra Şen, Deniz Yılmaz Karapınar, Elif Azarsız, Şöhret Aydemir, Fadıl Vardar
Despite improvements in diagnosis and treatment, infections are still major cause of morbidity and mortality in children with febrile neutropenia. In majority of febrile episodes, infection source cannot be defined. In this study, we aim to identify the earlier predictors of bacteremia/fungemia and a useful cytokine identify the source of infections and to discriminate the patients with culture-confirmed bacterial/fungal infection. The most sensitive cytokine was IL (Interleukin)-10 and the most specific was IL-8 in predicting culture-confirmed...
February 1, 2017: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
https://www.readbyqxmd.com/read/28131716/nosocomial-fungemia-by-candida-auris-first-four-reported-cases-in-continental-europe
#5
Alba Cecilia Ruiz Gaitán, Ana Moret, José Luis López Hontangas, José Miguel Molina, Ana Isabel Aleixandre López, Alicia Hernández Cabezas, Juan Mollar Maseres, Rabat Chouman Arcas, María Dolores Gómez Ruiz, Miguel Ángel Chiveli, Emilia Cantón, Javier Pemán
BACKGROUND: Candida auris is an emerging multidrug-resistant yeast that can cause invasive infections and is associated with high mortality. It is typically resistant to fluconazole and voriconazole and, some cases, also to echinocandins and amphotericin B. This species, phylogenetically related to Candida haemulonii, is frequently misidentified by commercial identification techniques in clinical laboratories; therefore, the real prevalence of C. auris infections may be underestimated...
January 25, 2017: Revista Iberoamericana de Micología
https://www.readbyqxmd.com/read/28127943/fungal-endotipsitis-a-case-report-and-literature-review
#6
Thomas R McCarty, Jordan Sack, Bakhtiar Syed, Roger Kim, Basile Njei
Endotipsitis is a broad term used to describe sustained and clinically significant bacteremia or fungemia from a suspected vegetation or thrombus within the transjugular intrahepatic portosytemic shunt (TIPS) device. Endotipsitis is a rare infection in post-TIPS patients and given the diagnostic challenges, there is a need to establish formal diagnostic criteria. Bacterial causes of endotipsitis have been well documented in the literature, but few fungal-associated etiologies have been published to date. With this paucity of data, treatment strategies are lacking regarding the role of antifungal duration, the aggressiveness of medical therapy, and the role of liver transplantation...
January 27, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28100311/the-evaluation-of-three-different-bottles-in-bactec-9240-automated-blood-culture-system-and-direct-identification-of-candida-species-to-shorten-the-turnaround-time-of-blood-culture
#7
Egemen Gokbolat, Yasemin Oz, Selma Metintas
Candida spp. are the most common causes of fungemia. Rapid and accurate diagnostic methods are very important for appropriate management of candidemia. At present, blood culture is the essential diagnostic test despite it has a long detection time and low sensitivity rate. We aimed to investigate the ways to shorten the turnaround time from blood culture collection to final identification in candidemia. Sixty clinical bloodstream isolates of Candida were included and the Plus Aerobic/F, Peds Plus/F and Mycosis IC/F (MICF) bottles were used with BACTEC 9240 blood culture instrument...
January 16, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28099778/pseudozyma-and-other-non-candida-opportunistic-yeast-bloodstream-infections-in-a-large-stem-cell-transplant-center
#8
Anupam Pande, Lemuel R Non, Rizwan Romee, Carlos A Q Santos
INTRODUCTION: Non-Candida opportunistic yeasts are emerging causes of bloodstream infection (BSI) in immunocompromised hosts. However, their clinical presentation, management, and outcomes in stem cell transplant (SCT) recipients are not well described. CASE REPORT AND REVIEW: We report the first case to our knowledge of Pseudozyma BSI in a SCT recipient. He had evidence of cutaneous involvement, which has not been previously described in the literature. He became infected while neutropenic and receiving empiric micafungin, which is notable because Pseudozyma is reported to be resistant to echinocandins...
January 18, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28098544/fatal-emmonsia-sp-infection-and-fungemia-after-orthotopic-liver-transplantation
#9
Shanthi Kappagoda, Jason Y Adams, Robert Luo, Niaz Banaei, Waldo Concepcion, Dora Y Ho
We report a fatal case of disseminated Emmonsia sp. infection in a 55-year-old man who received an orthotopic liver transplant. The patient had pneumonia and fungemia, and multisystem organ failure developed. As human habitats and the number of immunocompromised patients increase, physicians must be aware of this emerging fungal infection.
February 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28024866/saccharomyces-boulardii-probiotic-associated-fungemia-questioning-the-safety-of-this-preventive-probiotic-s-use
#10
Isabella W Martin, Rita Tonner, Julie Trivedi, Heather Miller, Richard Lee, Xinglun Liang, Leo Rotello, Elena Isenbergh, Jennifer Anderson, Trish Perl, Sean X Zhang
We report a case of fungemia in an immunocompetent patient after administration of probiotic containing Saccharomyces boulardii. We demonstrated the strain relatedness of the yeast from the probiotic capsule and the yeast causing fungal infection using genomic and proteomic typing methods. Our study questions the safety of this preventative biotherapy.
March 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/27995052/first-case-of-arthrographis-kalrae-fungemia-in-a-patient-with-cystic-fibrosis
#11
Julie Denis, Marcela Sabou, Tristan Degot, Ermanno Candolfi, Valérie Letscher-Bru
Arthrographis kalrae is a hyalin fungus. It is a saprophyte of the environment, mainly found in soil and compost. In recent years, cases of opportunistic infections attributed to this pathogen have been described. Our patient was a 19-year-old woman with cystic fibrosis. She presented a bacterial and fungal pulmonary colonization with Aspergillus fumigatus and Arthrographis. kalrae. After her lung transplantation, she developed an A. kalrae fungemia, treated with caspofungin 50 mg/day associated to liposomal amphotericin B i...
December 2016: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/27957359/disseminated-cryptococcal-disease-in-non-hiv-nontransplant-patient
#12
F AlMutawa, D Leto, Z Chagla
Disseminated cryptococcal infection carries a high risk of morbidity and mortality. Typical patients include HIV individuals with advanced immunosuppression or solid organ or hematopoietic transplant recipients. We report a case of disseminated cryptococcal disease in a 72-year-old male who was immunocompromised with chronic lymphocytic leukemia and ongoing chemotherapy. The patient presented with a subacute history of constitutional symptoms and headache after he received five cycles of FCR chemotherapy (fludarabine/cyclophosphamide/rituximab)...
2016: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/27872767/diffuse-alveolar-hemorrhage-associated-with-edoxaban-therapy
#13
Kenichi Nitta, Hiroshi Imamura, Akihiro Yashio, Satoko Kashima, Katsunori Mochizuki
Introduction. The main adverse effect of anticoagulant therapy is bleeding, and major bleeding, including intracranial, gastrointestinal, and retroperitoneal bleeding, has been reported as an adverse effect of edoxaban, a direct oral anticoagulant (DOAC). Bleeding during systemic anticoagulation with edoxaban presents a therapeutic conundrum, because there is currently no safe or efficacious reversal agent to stop major bleeding. Case Report. A 51-year-old woman had multiple traumatic injuries, including lower limb fractures...
2016: Case Reports in Critical Care
https://www.readbyqxmd.com/read/27859978/breakthrough-fungemia-due-to-candida-fermentati-with-fks1p-mutation-under-micafungin-treatment-in-a-cord-blood-transplant-recipient
#14
Takaaki Konuma, Shunsuke Takahashi, Tomohiko Kiyuna, Yuta Miharu, Masato Suzuki, Hiroko Shibata, Seiko Kato, Satoshi Takahashi, Arinobu Tojo
The prophylactic use of antifungal drugs in allogeneic hematopoietic cell transplant recipients has revealed that the rate of non-albicans candidemia has increased. We herein report the case of a patient with adult T-cell leukemia who developed candidemia due to Candida fermentati during micafungin treatment after cord blood transplantation. The isolate was identified on day 47 by sequencing of the internal transcribed spacer region of the ribosomal RNA gene. The sequencing of the hot spot region of fks1p of isolate revealed naturally occurring amino acid substitutions, which conferred reduced echinocandin susceptibility...
November 15, 2016: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/27851809/a-genome-wide-transcriptional-analysis-of-yeast-hyphal-transition-in-candida-tropicalis-by-rna-seq
#15
Yuan Wu, Yin-Hu Li, Shuan-Bao Yu, Wen-Ge Li, Xiao-Shu Liu, Lei Zhao, Jin-Xing Lu
Candida tropicalis is considered as the leading pathogen in nosocomial fungemia and hepatosplenic fungal infections in patients with cancer, particularly in leukemia. The yeast-filament transition is required for virulent infection by Candida. Several studies have explored the genome-wide transcription profile of Candida, however, no report on the transcriptional profile of C. tropicalis under yeast-filament transition has been published. In this study, the transcriptomes of three C. tropicalis isolates with different adhesion and biofilm formation abilities, identified in our previous studies, were analyzed in both the yeast and filament states using RNA-Seq...
2016: PloS One
https://www.readbyqxmd.com/read/27850292/653-outbreak-of-mixed-fungemia-in-a-children-s-intensive-care-unit-in-the-united-states
#16
Duha Al-Zubeidi
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27822975/risk-and-prognosis-of-bacteremia-and-fungemia-among-first-time-kidney-transplant-recipients-a-population-based-cohort-study
#17
Lars Skov Dalgaard, Mette Nørgaard, Johan Vestergaard Povlsen, Orla Morrissey, Bente Jespersen, Søren Jensen-Fangel, Lars J Østergaard, Henrik Carl Schønheyder, Ole Schmeltz Søgaard
BACKGROUND: Bacterial infections are common complications in kidney transplant recipients (KTRs). Little is known about incidence rates of bacteremia and fungemia (BAF) in KTRs. METHODS: In this population-based cohort study, we used medical and administrative registries to identify episodes of BAF among KTRs in the Central Denmark and North Denmark Regions during 1995-2010. KTRs were followed from the date of their first transplantation to the earliest of BAF, graft loss, death, emigration or 31 December 2010...
April 2017: Infectious Diseases
https://www.readbyqxmd.com/read/27801509/anti-rhodotorula-activity-of-mycophenolic-acid-enhanced-in-the-presence-of-polyene-antibiotic-nystatin
#18
H Kinoshita, S Wongsuntornpoj, F Ihara, T Nihira
: Rhodotorula species are opportunistic pathogens, which cause not only systemic fungaemia but also other localized infections. Despite serious side effects such as nephrotoxicity and hypokalemia, amphotericin B (a polyene antifungal) has been commonly prescribed for Rhodotorula infection because Rhodotorula species are resistant against a candin family of antifungal agents. In this study, novel active compounds against Rhodotorula species were screened from the extracts of entomopathogenic fungi based on the synergistic effect of polyene nystatin (NYS), which causes efficient targeting of compounds due to increased permeability through the fungal cell membrane...
February 2017: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/27801382/an-unusual-case-of-candida-ciferrii-fungemia-in-an-immunocompromised-patient-with-crohn-s-and-mycobacterium-bovis-disease
#19
Hiram Villanueva-Lozano, Rogelio de J Treviño-Rangel, Cristina L Hernández-Balboa, Gloria M González, Michel F Martínez-Reséndez
We present a case report of a fungal bloodstream infection due to an unusual pathogen. This is a 30 years-old female patient diagnosed with Crohn's disease and a disseminated Mycobacterium bovis infection subsequently complicated by fungemia due to the emergent yeast pathogen Candida ciferrii, who was unresponsive to fluconazole and made a full recovery after treatment with posaconazole. To our knowledge, this is the first report of Candida ciferrii isolation from blood in an adult associated to a central venous catheter and which was successfully treated with posaconazole...
October 31, 2016: Journal of Infection in Developing Countries
https://www.readbyqxmd.com/read/27795342/performance-of-matrix-assisted-laser-desorption-ionization-time-of-flight-mass-spectrometry-for-identifying-clinical-malassezia-isolates
#20
Julie Denis, Marie Machouart, Florent Morio, Marcela Sabou, Catherine Kauffmann-LaCroix, Nelly Contet-Audonneau, Ermanno Candolfi, Valérie Letscher-Bru
The genus Malassezia comprises commensal yeasts on human skin. These yeasts are involved in superficial infections but are also isolated in deeper infections, such as fungemia, particularly in certain at-risk patients, such as neonates or patients with parenteral nutrition catheters. Very little is known about Malassezia epidemiology and virulence. This is due mainly to the difficulty of distinguishing species. Currently, species identification is based on morphological and biochemical characteristics. Only molecular biology techniques identify species with certainty, but they are time-consuming and expensive...
January 2017: Journal of Clinical Microbiology
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