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https://www.readbyqxmd.com/read/29767394/prognostic-factors-and-scoring-model-of-hematological-malignancies-patients-with-bloodstream-infections
#1
Yishu Tang, Qian Cheng, Qing Yang, Jing Liu, Di Zhang, Wei Cao, Qingxia Liu, Tianyi Zhou, Huiqi Zeng, Li Zhou, QinJin Wang, Huan Wei, Xin Li
PURPOSE: Patients with hematological malignancies (HMs) are at a higher risk for bloodstream infections (BSIs), which pose significant burden on morbidity and mortality. Better risk stratification helps in medical decision making, increasing efficiency and reducing economic burden. The aim of this study was to develop and validate a reliable prediction model which can be used to identify HM patients at higher risk for BSIs. METHODS: We conducted a retrospective cohort study in three university-affiliated hospitals in Hunan Province, China, from January 2010 to April 2015...
May 16, 2018: Infection
https://www.readbyqxmd.com/read/29736359/clinical-significance-of-candida-in-an-intraoperative-peritoneal-specimen-with-perforation-peritonitis-an-institutional-perspective
#2
Jagannath Pramod, Chellappa Vijayakumar, Krishnamachari Srinivasan, Nanda Kishore Maroju, Nagarajan Raj Kumar, Gopal Balasubramaniyan
Introduction Fungal infection of the peritoneum has become more common in recent years, the most common cause of which is Candida. Candida peritonitis is considered as a severe disease and is regarded as an independent risk factor for mortality in postoperative peritonitis. This study was planned to find out the clinical significance of Candida isolation on the outcome of the patients with peritonitis in terms of morbidity and mortality. Methods This prospective study included consecutive patients admitted and operated for secondary peritonitis over a two-year period in a tertiary care hospital in South India...
March 5, 2018: Curēus
https://www.readbyqxmd.com/read/29731340/cryptococcus-laurentii-fungemia-in-a-low-birth-weight-preterm-neonate-india
#3
Minakshi Gupta, Asit K Mishra, Santosh K Singh
In the last few years, Cryptococcus laurentii infections have increased, particularly in immunocompromised patients. Here we report the first case of C. laurentii fungemia in low birth weight preterm infant from India. A preterm neonate was admitted for feeding intolerance and respiratory distress. Blood culture ascertained the causative organism as C. laurentii. The isolated strain was found susceptible to amphotericin B and the patient recovered following the administration of amphotericin B (5mg/kg body weight) for 8days...
April 30, 2018: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/29726396/complete-blood-cell-count-and-fungemia-diagnosis
#4
Aurélie Servonnet, Hervé Delacour
No abstract text is available yet for this article.
May 4, 2018: Annales de Biologie Clinique
https://www.readbyqxmd.com/read/29702054/prevalence-and-safety-of-intravenous-immunoglobulin-administration-during-maintenance-chemotherapy-in-children-with-acute-lymphoblastic-leukemia-in-first-complete-remission-a-health-maintenance-organization-perspective
#5
Patrick Van Winkle, Raoul Burchette, Raymond Kim, Rukmani Raghunathan, Naveen Qureshi
CONTEXT: Children with acute lymphoblastic leukemia (ALL) in first complete remission (CR1) experience hypogammaglobulinemia and are at risk of sepsis during maintenance chemotherapy. Intravenous immunoglobulin (IVIG) has been used to try to circumvent this risk, but no data exist regarding its safety and prevalence in a health maintenance organization. OBJECTIVE: To evaluate the prevalence and safety of IVIG in children with ALL in CR1 during maintenance chemotherapy...
April 9, 2018: Permanente Journal
https://www.readbyqxmd.com/read/29699503/comparison-of-the-incidence-clinical-features-and-outcomes-of-invasive-candidiasis-in-children-and-neonates
#6
Jen-Fu Hsu, Mei-Yin Lai, Chiang-Wen Lee, Shih-Ming Chu, I-Hsyuan Wu, Hsuan-Rong Huang, I-Ta Lee, Ming-Chou Chiang, Ren-Huei Fu, Ming-Horng Tsai
BACKGROUND: Invasive candidiasis differs greatly between children and neonates. We aimed to investigate the different therapeutic approaches and their effects on treatment outcomes of these two groups. METHODS: Episodes of neonatal invasive candidiasis were compared with non-neonatal pediatric episodes during a 12-year cohort study. Clinical isolates were documented by matrix-assisted laser desorption/ionization-time of flight mass spectrometry and DNA sequencing, and antifungal susceptibility testing was performed...
April 24, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29698435/airborne-transmission-of-invasive-fusariosis-in-patients-with-hematologic-malignancies
#7
Maria Luiza Moretti, Ariane Fidelis Busso-Lopes, Cibele Aparecida Tararam, Renato Moraes, Yasunori Muraosa, Yuzuru Mikami, Tohru Gonoi, Hideaki Taguchi, Luzia Lyra, Franqueline Reichert-Lima, Plínio Trabasso, Gerrit Sybren de Hoog, Abdullah Mohammed Said Al-Hatmi, Angelica Zaninelli Schreiber, Katsuhiko Kamei
From 2006 to 2013, an increasing incidence of fusariosis was observed in the hematologic patients of our University Hospital. We suspected of an environmental source, and the indoor hospital air was investigated as a potential source of the fungemia. Air samplings were performed in the hematology and bone marrow transplant (BMT) wards using an air sampler with pre-defined air volumes. To study the molecular relationship among environmental and clinical isolates, 18 Fusarium spp. recovered from blood cultures were included in the study...
2018: PloS One
https://www.readbyqxmd.com/read/29691073/microbiological-diagnosis-of-bacteraemia-and-fungaemia-blood-cultures-and-molecular-methods
#8
María Remedio Guna Serrano, Nieves Larrosa Escartín, Mercedes Marín Arriaza, Juan Carlos Rodríguez Díaz
OBJETIVE: In this review we try to update the new procedures applicable in the microbiological diagnosis of bacteriemia and fungemias. METHOD: Review of scientific literature. RESULTS AND CONCLUSIONS: After defining the process and indicating its fundamental principles, the main biomarkers used in clinical practice are reviewed. Subsequently, the particularities of the pre-analytical phase (collection and transport of samples) are highlighted and the steps to follow for the microbiological identification by classical methods are detailed, based on the culture of the blood samples...
April 21, 2018: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/29679424/lomentospora-prolificans-fungemia-in-hematopoietic-stem-cell-transplant-patients-first-report-in-south-america-and-literature-review
#9
Fernando D Penteado, Nadia Litvinov, Jaques Sztajnbok, Danilo Y Thomaz, Antonio M Dos Santos, Dewton M Vasconcelos, Adriana L Motta, Flávia Rossi, Juliana F Fernandes, Heloisa Helena S Marques, Gil Benard, João N de Almeida Júnior
Lomentospora prolificans is a filamentous fungus and an emerging pathogen in immunocompromised patients. It is encountered most commonly in Australia, Spain, and USA. We described the first case of Lomentospora prolificans fungemia in South America. The patient was a hematopoietic stem cell transplantation (HSCT) recipient who developed the infection 37 days after stem cells infusion. In addition, we performed a literature review of invasive lomentosporiosis in HSCT patients. This article is protected by copyright...
April 20, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29668120/cytomegalovirus-infection-in-living-donor-liver-transplant-recipients-significantly-impacts-the-early-post-transplant-outcome-a-single-center-experience
#10
Sanjay Kumar Yadav, Sanjiv Saigal, Narendra Singh Choudhary, Sujeet Saha, Jayant Kumar Sah, Neeraj Saraf, Naveen Kumar, Sanjay Goja, Amit Rastogi, Prashant Bhangui, A S Soin
BACKGROUND: Cytomegalovirus (CMV) is the most common viral infection in liver transplant recipients that influences the outcomes of liver transplantation. However, its impact on early outcomes following living donor liver transplantation (LDLT) is not fully defined in the Indian subcontinent. This study was done to assess the impact of CMV infection on early post-transplant outcomes in LDLT recipients. METHODS: Out of 272 LDLTs performed from January 2012 to April 2013, 151 recipients underwent CMV viral load analysis in plasma within 90 days post LDLT based on clinical suspicion...
April 18, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29661607/catheter-related-bloodstream-infection-due-to-rhodotorula-mucilaginosa-with-normal-serum-1%C3%A2-3-%C3%AE-d-glucan-level
#11
T Kitazawa, S Ishigaki, K Seo, Y Yoshino, Y Ota
Rhodotorula species are environmental basidiomycete yeasts that have emerged as a cause of fungemia in immunocompromised hosts. The insertion of a central venous catheter was identified as a major risk factor for Rhodotorula fungemia. Few cases reports have reported (1→3)-β-D-glucan testing at the onset of Rhodotorula mucilaginosa fungemia. We report a case of catheter-related bloodstream infection due to R. mucilaginosa. Serum β-D-glucan level was normal at the onset of the bloodstream infection. It took 5 days to culture the isolate...
April 13, 2018: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/29642960/cyp51-as-drug-targets-for-fungi-and-protozoan-parasites-past-present-and-future
#12
Galina I Lepesheva, Laura Friggeri, Michael R Waterman
The efficiency of treatment of human infections with the unicellular eukaryotic pathogens such as fungi and protozoa remains deeply unsatisfactory. For example, the mortality rates from nosocomial fungemia in critically ill, immunosuppressed or post-cancer patients often exceed 50%. A set of six systemic clinical azoles [sterol 14α-demethylase (CYP51) inhibitors] represents the first-line antifungal treatment. All these drugs were discovered empirically, by monitoring their effects on fungal cell growth, though it had been proven that they kill fungal cells by blocking the biosynthesis of ergosterol in fungi at the stage of 14α-demethylation of the sterol nucleus...
April 12, 2018: Parasitology
https://www.readbyqxmd.com/read/29581112/survival-in-patients-with-candida-glabrata-bloodstream-infections-is-associated-with-fluconazole-dose
#13
Gregory A Eschenauer, Peggy L Carver, Twisha S Patel, Shu-Wen Lin, Kenneth P Klinker, Manjunath P Pai, Simon W Lam
Robust pharmacodynamic indices that align fluconazole dose or exposure with outcome in invasive candidiasis due to C. glabrata remain elusive. The purpose of this retrospective, multicenter study was to evaluate a cohort of 127 patients with C. glabrata fungemia treated with fluconazole using adjusted analyses to identify risk factors for 28-day mortality. No significant correlations were found between fluconazole AUC, AUC:MIC, or MIC and survival. However, on multivariable logistic regression, higher average fluconazole dose (odds ratio (OR) 1...
March 26, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29575315/candida-utilis-fungemia-following-endoscopic-intervention-on-ureteral-stent-in-a-kidney-transplant-recipient-case-report-and-a-review-of-the-literature
#14
REVIEW
Raphaël Gaisne, Fakhri Jeddi, Florent Morio, Quentin-Côme Le Clerc, Maryvonne Hourmant, Gilles Blancho, Magali Giral, Diego Cantarovich, Jacques Dantal, Simon Ville
Infection due to species other than Candida albicans is increasing among solid organ transplant recipients. Candida utilis, commonly used in the food industry, is considered as a low-virulence yeast. We report the first case of C. utilis fungemia involving a solid organ transplant recipient. The infection was triggered by the withdrawal of a ureteral stent and was successfully treated with intravenous micafungin. We also propose a review of all reported cases of infection caused by C. utilis. This article is protected by copyright...
March 25, 2018: Mycoses
https://www.readbyqxmd.com/read/29569576/urinary-tract-infection-due-to-fusarium-oxysporum-in-an-immunocompetent-patient-with-chronic-kidney-disease
#15
Khetan Seema, Khetan Prakash, Katkar Venkatesh, Kusulkar Minal
Infections due to Fusarium species are collectively referred to as fusariosis. Fusarium oxysporum has been reported to cause keratitis, onychomycosis, skin infections, catheter associated fungemia and has not been described as a cause of urinary tract infection. Here, we present the first case of fusariosis with urinary tract involvement in a 67 year old male, with chronic kidney disease and type 2 diabetes mellitus. This case illustrates the ever increasing spectrum of rare but offending pathogenic fungi. Early diagnosis of infection with a specific pathogen may lead to changes in antifungal therapy and may be critical for an improved outcome...
November 1, 2017: Journal of Biomedical Research
https://www.readbyqxmd.com/read/29561459/uncommon-cause-of-fungemia-in-a-patient-with-renal-cell-cancer-a-case-report-of-candida-lusitaniae-fungemia-erratum
#16
(no author information available yet)
No abstract text is available yet for this article.
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29530846/micafungin-breakthrough-fungemia-in-patients-with-hematological-disorders
#17
Muneyoshi Kimura, Hideki Araoka, Hisashi Yamamoto, Shigeki Nakamura, Minoru Nagi, Satoshi Yamagoe, Yoshitsugu Miyazaki, Sho Ogura, Takashi Mitsuki, Mitsuhiro Yuasa, Daisuke Kaji, Kosei Kageyama, Aya Nishida, Yuki Taya, Hiroshi Shimazu, Kazuya Ishiwata, Shinsuke Takagi, Go Yamamoto, Yuki Asano-Mori, Naoyuki Uchida, Atsushi Wake, Shuichi Taniguchi, Akiko Yoneyama
Limited data are available on micafungin breakthrough fungemia (MBF), fungemia that develops on administration of micafungin, in patients with hematological disorders. We reviewed medical and microbiological records of patients with hematological disorders who developed MBF between January 2008 and June 2015. A total of 39 patients with MBF were identified, and Candida (30 strains) and non- Candida (9 strains) fungal species were recognized as causative strains. Among 35 stored strains, Candida parapsilosis (14 strains), Trichosporon asahii (7 strains), Candida glabrata (5 strains), and other fungal species (9 strains) were identified by sequencing...
May 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29505004/fungemia-caused-by-penicillium-marneffei-in-an-immunocompetent-patient-with-copd-a-unique-case-report
#18
Xiaoming Yu, Xueding Cai, Xiaomei Xu, Lin Zhang, Xiaoying Huang, Liangxing Wang, Yanfan Chen
RATIONALE: This report describes a rare case in Wenzhou city of Zhejiang province that a non-HIV infected male recovering from fungemia caused by Penicillium marneffei (P. marneffei). Interestingly, it's very easy to misdiagnose with aspergillosis, a fungal disease prevalent in Wenzhou, during the whole procedure. PATIENT CONCERNS: An 80-year-old Chinese male subject with pre-existing chronic obstructive pulmonary disease (COPD) presented with symptoms of chest tightness and high fever for a month...
January 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29404266/necrotizing-fungal-gingivitis-in-a-patient-with-acute-myelogenous-leukemia-visible-yet-obscure
#19
Prajwal Boddu, Pei-Ling Chen, Priyadharsini Nagarajan, Victor G Prieto, Alex Won, Mark Chambers, Steven Kornblau
Oral fungal infections present with atypical and varied manifestations, and distinguishing them from other entities including leukemic infiltration can be diagnostically challenging. In this report, we describe a 62 year old female with acute myeloid leukemia who presented, towards the end of her second treatment cycle of decitabine in a prolonged neutropenic state, with a month of painful, necrotic-appearing marginal gingival lesions. She was duly initiated on empiric broad spectrum antifungal treatment but did not show a clinical response with the appearance of new skin lesions concerning for progressive fungemia...
January 2018: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology
https://www.readbyqxmd.com/read/29383496/candidemia-after-endoscopic-therapy-with-lumen-apposing-metal-stent-for-pancreatic-walled-off-necrosis
#20
Tajana Pavic, Davor Hrabar, Dominik Kralj, Ivan Lerotic, Doris Ogresta
Necrotizing pancreatitis remains a challenging and unpredictable condition accompanied by various complications. Endoscopic ultrasound-guided transmural drainage and necrosectomy have become the standard treatment for patients with walled-off necrosis (WON). Endoscopic therapy via lumen-apposing metal stents (LAMS) with large diameters has shown success in the management of pancreatic fluid collections, but there are few data on specific complications of that therapy. We report a case of infected WON and concomitant fungemia following LAMS placement and necrosectomy...
January 30, 2018: Clinical Journal of Gastroenterology
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