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https://www.readbyqxmd.com/read/27872767/diffuse-alveolar-hemorrhage-associated-with-edoxaban-therapy
#1
Kenichi Nitta, Hiroshi Imamura, Akihiro Yashio, Satoko Kashima, Katsunori Mochizuki
Introduction. The main adverse effect of anticoagulant therapy is bleeding, and major bleeding, including intracranial, gastrointestinal, and retroperitoneal bleeding, has been reported as an adverse effect of edoxaban, a direct oral anticoagulant (DOAC). Bleeding during systemic anticoagulation with edoxaban presents a therapeutic conundrum, because there is currently no safe or efficacious reversal agent to stop major bleeding. Case Report. A 51-year-old woman had multiple traumatic injuries, including lower limb fractures...
2016: Case Reports in Critical Care
https://www.readbyqxmd.com/read/27859978/breakthrough-fungemia-due-to-candida-fermentati-with-fks1p-mutation-under-micafungin-treatment-in-a-cord-blood-transplant-recipient
#2
Takaaki Konuma, Shunsuke Takahashi, Tomohiko Kiyuna, Yuta Miharu, Masato Suzuki, Hiroko Shibata, Seiko Kato, Satoshi Takahashi, Arinobu Tojo
The prophylactic use of antifungal drugs in allogeneic hematopoietic cell transplant recipients has revealed that the rate of non-albicans candidemia has increased. We herein report the case of a patient with adult T-cell leukemia who developed candidemia due to Candida fermentati during micafungin treatment after cord blood transplantation. The isolate was identified on day 47 by sequencing of the internal transcribed spacer region of the ribosomal RNA gene. The sequencing of the hot spot region of fks1p of isolate revealed naturally occurring amino acid substitutions, which conferred reduced echinocandin susceptibility...
November 15, 2016: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/27851809/a-genome-wide-transcriptional-analysis-of-yeast-hyphal-transition-in-candida-tropicalis-by-rna-seq
#3
Yuan Wu, Yin-Hu Li, Shuan-Bao Yu, Wen-Ge Li, Xiao-Shu Liu, Lei Zhao, Jin-Xing Lu
Candida tropicalis is considered as the leading pathogen in nosocomial fungemia and hepatosplenic fungal infections in patients with cancer, particularly in leukemia. The yeast-filament transition is required for virulent infection by Candida. Several studies have explored the genome-wide transcription profile of Candida, however, no report on the transcriptional profile of C. tropicalis under yeast-filament transition has been published. In this study, the transcriptomes of three C. tropicalis isolates with different adhesion and biofilm formation abilities, identified in our previous studies, were analyzed in both the yeast and filament states using RNA-Seq...
2016: PloS One
https://www.readbyqxmd.com/read/27850292/653-outbreak-of-mixed-fungemia-in-a-children-s-intensive-care-unit-in-the-united-states
#4
Duha Al-Zubeidi
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27822975/risk-and-prognosis-of-bacteremia-and-fungemia-among-first-time-kidney-transplant-recipients-a-population-based-cohort-study
#5
Lars Skov Dalgaard, Mette Nørgaard, Johan Vestergaard Povlsen, Orla Morrissey, Bente Jespersen, Søren Jensen-Fangel, Lars J Østergaard, Henrik Carl Schønheyder, Ole Schmeltz Søgaard
BACKGROUND: Bacterial infections are common complications in kidney transplant recipients (KTRs). Little is known about incidence rates of bacteremia and fungemia (BAF) in KTRs. METHODS: In this population-based cohort study, we used medical and administrative registries to identify episodes of BAF among KTRs in the Central Denmark and North Denmark Regions during 1995-2010. KTRs were followed from the date of their first transplantation to the earliest of BAF, graft loss, death, emigration or 31 December 2010...
November 8, 2016: Infectious Diseases
https://www.readbyqxmd.com/read/27801509/anti-rhodotorula-activity-of-mycophenolic-acid-enhanced-in-the-presence-of-polyene-antibiotic-nystatin
#6
H Kinoshita, S Wongsuntornpoj, F Ihara, T Nihira
: Rhodotorula species are opportunistic pathogens, which cause not only systemic fungaemia but also other localized infections. Despite serious side effects such as nephrotoxicity and hypokalemia, amphotericin B (a polyene antifungal) has been commonly prescribed for Rhodotorula infection because Rhodotorula species are resistant against a candin family of antifungal agents. In this study, novel active compounds against Rhodotorula species were screened from the extracts of entomopathogenic fungi based on the synergistic effect of polyene nystatin (NYS), which causes efficient targeting of compounds due to increased permeability through the fungal cell membrane...
November 1, 2016: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/27801382/an-unusual-case-of-candida-ciferrii-fungemia-in-an-immunocompromised-patient-with-crohn-s-and-mycobacterium-bovis-disease
#7
Hiram Villanueva-Lozano, Rogelio de J Treviño-Rangel, Cristina L Hernández-Balboa, Gloria M González, Michel F Martínez-Reséndez
We present a case report of a fungal bloodstream infection due to an unusual pathogen. This is a 30 years-old female patient diagnosed with Crohn's disease and a disseminated Mycobacterium bovis infection subsequently complicated by fungemia due to the emergent yeast pathogen Candida ciferrii, who was unresponsive to fluconazole and made a full recovery after treatment with posaconazole. To our knowledge, this is the first report of Candida ciferrii isolation from blood in an adult associated to a central venous catheter and which was successfully treated with posaconazole...
October 31, 2016: Journal of Infection in Developing Countries
https://www.readbyqxmd.com/read/27795342/performance-of-matrix-assisted-laser-desorption-ionisation-time-of-flight-mass-spectrometry-for-identifying-clinical-malassezia-isolates
#8
Denis Julie, Machouart Marie, Morio Florent, Sabou Marcela, Kauffmann-Lacroix Catherine, Contet-Audonneau Nelly, Candolfi Ermanno, Letscher-Bru Valérie
The genus Malassezia comprises commensal yeasts on human skin. They are involved in superficial infections, but also isolated in deeper infections such as fungemia, particularly in certain at-risk patients, such as neonates or patients with parenteral nutrition catheters. Very little is known about their epidemiology and their virulence. This is mainly due to the difficulty to differentiate species. Currently, species identification is based on morphological and biochemical characteristics. Only molecular biology techniques identify species with certainty but they are time consuming and expensive...
October 19, 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27777804/detection-of-the-dimorphic-phases-of-mucor-circinelloides-in-blood-cultures-from-an-immunosuppressed-female
#9
Miguel A Arroyo, Bryan H Schmitt, Thomas E Davis, Ryan F Relich
Mucormycosis fungemia is rarely documented since blood cultures are nearly always negative. We describe a case of Mucor circinelloides fungemia in a patient with a history of a sinus infection, sarcoidosis, and IgG deficiency. The identity of the isolate was supported by its microscopic morphology and its ability to convert into yeast forms under anaerobic conditions. The early detection, initiation of liposomal amphotericin B treatment, and reversal of underlying predisposing risk factors resulted in a good outcome...
2016: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/27775765/association-between-antibiotic-use-and-neonatal-mortality-and-morbidities-in-very-low-birth-weight-infants-without-culture-proven-sepsis-or-necrotizing-enterocolitis
#10
Joseph Y Ting, Anne Synnes, Ashley Roberts, Akhil Deshpandey, Kimberly Dow, Eugene W Yoon, Kyong-Soon Lee, Simon Dobson, Shoo K Lee, Prakesh S Shah
Importance: Excessive antibiotic use has been associated with altered bacterial colonization and may result in antibiotic resistance, fungemia, necrotizing enterocolitis (NEC), and mortality. Exploring the association between antibiotic exposure and neonatal outcomes other than infection-related morbidities may provide insight on the importance of rational antibiotic use, especially in the setting of culture-negative neonatal sepsis. Objective: To evaluate the trend of antibiotic use among all hospitalized very low-birth-weight (VLBW) infants across Canada and the association between antibiotic use rates (AURs) and mortality and morbidity among neonates without culture-proven sepsis or NEC...
December 1, 2016: JAMA Pediatrics
https://www.readbyqxmd.com/read/27771657/saccharomyces-kluyveri-fungemia-in-an-infant-with-severe-combined-immunodeficiency
#11
Shakil Shaikh, Ira Shah
No abstract text is available yet for this article.
September 8, 2016: Indian Pediatrics
https://www.readbyqxmd.com/read/27747250/probiotics-in-human-immunodeficiency-virus-infection-a-systematic-review-and-evidence-synthesis-of-benefits-and-risks
#12
George M Carter, Aryan Esmaeili, Hardikkumar Shah, Debbie Indyk, Matthew Johnson, Michael Andreae, Henry S Sacks
People living with human immunodeficiency virus frequently use dietary supplements, including probiotics, but concern exists about ingesting live organisms. We performed a systematic review of the benefits of probiotics and a meta-analysis of sepsis risk. We undertook a protocol-driven, comprehensive review to identify all relevant studies, assess their quality, and summarize the evidence. Of 2068 references, 27 were analyzed. The data suggest possible benefits for CD4 count, recurrence or management of bacterial vaginosis, and diarrhea management...
October 2016: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/27742285/invasive-fungal-disease-in-renal-transplant-recipients-at-a-brazilian-center-local-epidemiology-matters
#13
L F A Guimarães, M Halpern, A S de Lemos, E F de Gouvêa, R T Gonçalves, M A A da Rosa Santos, M Nucci, G Santoro-Lopes
INTRODUCTION: Invasive fungal disease (IFD) is an important complication after solid organ transplantation (SOT). A marked geographic variation in the epidemiology of IFD after kidney transplantation (KT) has been suggested by the results of previous studies. Nevertheless, data from Latin American centers are scarce. OBJECTIVE: This study sought to describe the epidemiology of IFD at a Brazilian KT center. METHODS: This study was a retrospective single-center cohort study that included patients who underwent KT between 1998 and 2009 and were followed up until July 2015...
September 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27736956/a-dedicated-fungal-culture-medium-is-useful-in-the-diagnosis-of-fungemia-a-retrospective-cross-sectional-study
#14
Shuwei Zheng, Tong Yong Ng, Huihua Li, Ai Ling Tan, Thuan Tong Tan, Ban Hock Tan
BACKGROUND: Mortality for candidemia ranges from 15% to 35%. Current guidelines recommend inoculating blood into three aerobic and three anaerobic blood culture bottles when candidemia is suspected, without mention of a fungal blood culture bottle. OBJECTIVE: To determine the value of the BACTEC Myco/F Lytic blood culture media in the diagnosis of fungemia. METHODS: A two-year retrospective cross-sectional study was performed for patients who had fungemia with submitted BACTEC Plus Aerobic/F (Aer), BACTEC Plus Anaerobic/F (Anaer) or Myco/F Lytic (Myco) blood culture bottles...
2016: PloS One
https://www.readbyqxmd.com/read/27689116/splenic-abscess-due-to-fungal-infection-after-kidney-transplantation-a-case-report
#15
Tahereh Malakoutian, Maliheh Yarmohamadi, Ronak Mohammadi, Mojgan Asgari, Reyhaneh Mahmoodian
Splenic abscess is one of the rare and potentially life-threatening complications after kidney transplantation. Splenic abscess generally occurs in patients who have immunodeficiency state. It becomes more important with the increased use of immunosuppressed drugs and organ transplantation. The clinical presentation of splenic abscess is insidious, often with constitutional symptoms. Left upper quadrant tenderness is an uncommon sign. Therefore, its diagnosis is difficult and requires a high degree of clinical suspicion...
2016: Journal of Renal Injury Prevention
https://www.readbyqxmd.com/read/27677278/comparison-of-bactec%C3%A2-blood-culture-media-for-the-detection-of-fungemia
#16
R Datcu, J Boel, I M Jensen, M Arpi
The aim of the present study was to investigate whether addition of the BACTEC™ Mycosis bottle to the standard BACTEC™ aerobic and anaerobic bottles contributed to a higher detection rate and a faster time to detection (TTD) of fungi. This was a retrospective cohort study of all patients with a positive blood culture with Candida species delivered to the Department of Clinical Microbiology, Herlev and Gentofte Hospital, Denmark in the 8-year period 2006 through 2014. The patients had at least one BACTEC™ aerobic and one Mycosis bottle sampled at the same time and at least one of the bottles yielded growth of fungi...
September 27, 2016: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/27642562/successful-therapy-of-candida-pulcherrima-fungemia-in-a-premature-newborn-with-liposomal-amphotericin-b-and-micafungin
#17
Alexandra Mpakosi, Maria Siopi, Vasiliki Falaina, Nikolaos Siafakas, Emmanuel Roilides, Maria Kimouli, Martha Theodoraki, Paraskevi Karle, Joseph Meletiadis
New Candida species may cause bloodstream infections challenging current therapeutic approaches because of unpredictable susceptibility and virulence. In the present report, we describe a fungemia case due to Candida pulcherrima in a premature neonate. After full in vitro diagnostic workup, the neonate was successfully treated with liposomal amphotericin B and micafungin achieving rapid fungal eradication from blood.
June 2016: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/27630816/fungemia-due-to-kodamaea-ohmeri-in-a-young-infant-and-review-of-the-literature
#18
Rosalba Vivas, Claudia Beltran, Maria Isabel Munera, Monica Trujillo, Andrea Restrepo, Carlos Garcés
Fungal infections have become an important cause of morbidity and mortality in hospitalized children due to many complicating and underlying conditions. We present the case of a newborn infant with fungemia due to Kodamaea ohmeri who had a good outcome of the infection after using the combination of antifungal treatment and central venous catheter removal.
September 2016: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/27601609/unique-characteristics-of-cryptococcosis-identified-after-death-in-patients-with-liver-cirrhosis-comparison-with-concurrent-cohort-diagnosed-antemortem
#19
Nina Singh, Costi D Sifri, Fernanda P Silveira, Rachel Miller, Kevin S Gregg, Shirish Huprikar, Erika D Lease, Andrea Zimmer, J Stephen Dummer, Cedric W Spak, Christine Koval, David B Banach, Miloni Shroff, Jade Le, Darin Ostrander, Robin Avery, Albert Eid, Raymund R Razonable, Jose Montero, Emily Blumberg, Ahlaam Alynbiawi, Michele I Morris, Henry B Randall, George Alangaden, Jeffrey Tessier, Thomas V Cacciarelli, Marilyn M Wagener, Hsin Yun Sun
Characteristics of cirrhosis-associated cryptococcosis first diagnosed after death are not fully known. In a multicenter study, data generated as standard of care was systematically collected in 113 consecutive patients with cirrhosis and cryptococcosis followed for 80 patient-years. The diagnosis of cryptococcosis was first established after death in 15.9% (18/113) of the patients. Compared to cases diagnosed while alive, these patients had higher MELD score (33 vs. 22, P = .029) and higher rate of cryptococcemia (75...
September 6, 2016: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/27591280/a-comparison-of-mott-cell-morphology-of-three-avian-species-ii-bad-behavior-by-plasmacytes
#20
Paul F Cotter, Murray R Bakst
Mott cells are atypical plasmacytes recognized microscopically by endoplasmic reticulum (ER) distensions (Russell bodies) a result of retained secretory product (antibody). Originally associated with parasitism, they are observed in a broad spectrum of immunopathology, sometimes involving hypergammaglobulinemia. Few descriptions of Mott cells appear in avian literature. The purpose of the manuscript is to provide examples identified by light microscopy in three poultry species. Transmission electron micrographs (TEM) of plasmacytes from the turkey oviduct mucosa are included for comparison with Mott cell light microscopic images...
September 2, 2016: Poultry Science
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