Farnaz Daneshnia, Daniel J Floyd, Adam P Ryan, Pegah Mosharaf Ghahfarokhy, Arefeh Ebadati, Sebastian Jusuf, Julieta Munoz, Nathan E Jeffries, Emma Elizabeth Yvanovich, Anna Apostolopoulou, Austin M Perry, Cornelia Lass-Flörl, Asuman Birinci, Süleyha Hilmioğlu-Polat, Macit Ilkit, Geraldine Butler, Clarissa J Nobile, Amir Arastehfar, Michael K Mansour
Candida parapsilosis is known to cause severe and persistent outbreaks in clinical settings. Patients infected with multidrug-resistant C. parapsilosis (MDR Cp) isolates were identified in a large Turkish hospital from 2017-2020. We subsequently identified three additional patients infected with MDR Cp isolates in 2022 from the same hospital and two echinocandin-resistant (ECR) isolates from a single patient in another hospital. The increasing number of MDR and ECR isolates contradicts the general principle that the severe fitness cost associated with these phenotypes could prevent their dominance in clinical settings...
February 21, 2024: Emerging Microbes & Infections