keyword
https://read.qxmd.com/read/38399419/efficacy-of-ceragenins-in-controlling-the-growth-of-oral-microorganisms-implications-for-oral-hygiene-management
#21
JOURNAL ARTICLE
Michał Czarnowski, Monika Słowińska, Mariusz Sawieljew, Urszula Wnorowska, Tamara Daniluk, Grzegorz Król, Maciej Karasiński, Sławomir Okła, Paul B Savage, Ewelina Piktel, Robert Bucki
Ensuring proper dental hygiene is of paramount importance for individuals' general well-being, particularly for patients receiving medical care. There is a prevailing utilization of conventional oral hygiene items, including toothbrushes and mouthwashes, which have gained widespread acceptance; nevertheless, their limitations encourage investigating novel options in this domain. Our study indicates that ceragenins (CSAs) being lipid analogs of host defense peptides, well-recognized for their wide-ranging antimicrobial properties, may be a potentially efficacious means to augment oral hygiene in hospitalized individuals...
February 5, 2024: Pharmaceuticals
https://read.qxmd.com/read/38397991/a-preliminary-evaluation-on-the-antifungal-efficacy-of-vt-1161-against-persister-candida-albicans-cells-in-vulvovaginal-candidiasis
#22
JOURNAL ARTICLE
Marica Sinoca, Angela Maione, Edvige Gambino, Marianna Imparato, Marilena Galdiero, Elisabetta de Alteriis, Emilia Galdiero, Marco Guida
Persister cells are a small fraction of the microbial population that survive lethal concentrations of antimicrobial agents. Candida albicans causes vaginal candidiasis, including recurrent vulvovaginal candidiasis, and may survive common antifungal treatments. The triazole VT-1161 is an antifungal agent that specifically targets fungal CYP51, as opposed to the human CYP enzyme. This work illustrates a new role of VT-1161 in eradicating the biofilm created from the persister cells of a primary biofilm of a clinical vaginal isolate of C...
February 7, 2024: Biomedicines
https://read.qxmd.com/read/38397912/antifungal-susceptibility-and-candida-sp-biofilm-production-in-clinical-isolates-of-hiv-positive-brazilian-patients-under-haart-therapy
#23
JOURNAL ARTICLE
Anelise Maria Costa Vasconcelos Alves, Érika Helena Salles de Brito, Márcio Flávio Moura de Araújo, Juliana Jales de Hollanda Celestino, Ana Caroline Rocha de Melo Leite, Gabriela Silva Cruz, Nuno Filipe Azevedo, Célia Fortuna Rodrigues
The aim of the present study was to characterize biofilms formed by Candida spp. clinical isolates (n = 19), isolated from the oral mucosa of HIV-positive patients. For characterizing the biofilms formed by several Candida sp. strains, isolated from HIV-positive patients, in terms of formed biomass, matrix composition and antifungal susceptibility profile, clinical isolates (n = 19) were collected from oral mucosa and identified. The biofilm of the samples was cultured with fluconazole (1250 mg/L), voriconazole (800 mg/L), anidulafungin (2 mg/L) or amphotericin B (2 mg/L)...
January 29, 2024: Biomedicines
https://read.qxmd.com/read/38397101/inhibition-of-biofilm-formation-in-cutibacterium-acnes-staphylococcus-aureus-and-candida-albicans-by-the-phytopigment-shikonin
#24
JOURNAL ARTICLE
Yong-Guy Kim, Jin-Hyung Lee, Sang-Hun Kim, Sun-Young Park, Yu-Jeong Kim, Choong-Min Ryu, Hwi-Won Seo, Jin-Tae Lee
Skin microbiota, such as acne-related Cutibacterium acnes , Staphylococcus aureus , and fungal Candida albicans , can form polymicrobial biofilms with greater antimicrobial tolerance to traditional antimicrobial agents and host immune systems. In this study, the phytopigment shikonin was investigated against single-species and multispecies biofilms under aerobic and anaerobic conditions. Minimum inhibitory concentrations of shikonin were 10 µg/mL against C. acnes , S. aureus , and C. albicans , and at 1-5 µg/mL, shikonin efficiently inhibited single biofilm formation and multispecies biofilm development by these three microbes...
February 19, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38396469/covid-19-associated-rhino-orbital-mucormycosis-histological-and-electron-microscopy-characteristics
#25
JOURNAL ARTICLE
Ionuț Isaia Jeican, Delia Ioana Horhat, Mihai Dumitru, Adrian Florea, Lucian Barbu-Tudoran, Bogdan-Alexandru Gheban, Vlad Anton, Corneliu Toader, Maria Aluaș, Costel Vasile Siserman, Nicolae Balica, Daniela Vrînceanu, Silviu Albu
COVID-19-associated rhino-orbital mucormycosis has become a new clinical entity. This study's aim was to evaluate the histopathological and ultramicroscopic morphological aspects of this fungal infection. This was an observational retrospective study on eight patients from three tertiary centers in Romania. The tissue samples collected during functional endoscopic sinus surgery were studied through histopathological examination, scanning electron microscopy, and transmission electron microscopy. In the histopathological examination, the morphological aspects characteristic of mucormycosis in all cases were identified: wide aseptate hyphae with right-angle ramifications, which invade blood vessels...
February 15, 2024: Diagnostics
https://read.qxmd.com/read/38390467/ecological-competition-in-the-oral-mycobiome-of-hispanic-adults-living-in-puerto-rico-associates-with-periodontitis
#26
JOURNAL ARTICLE
Kimil Acosta-Pagán, Benjamín Bolaños-Rosero, Cynthia Pérez, Ana P Ortíz, Filipa Godoy-Vitorino
Background: Fungi are a major component of the human microbiome that only recently received attention. The imbalance of indigenous fungal communities and environmental fungi present in the oral cavity may have a role in oral dysbiosis, which could exacerbate oral inflammatory diseases. Methods: We performed a cross-sectional study and recruited 88 participants aged 21 to 49 from sexually transmitted infection clinics in Puerto Rico. A full-mouth periodontal examination following the NHANES protocol defined periodontal severity (CDC/AAP)...
2024: Journal of Oral Microbiology
https://read.qxmd.com/read/38385528/promising-activity-of-etomidate-against-mixed-biofilms-of-fluconazole-resistant-candida-albicans-and-methicillin-resistant-staphylococcus-aureus
#27
JOURNAL ARTICLE
Cecília Rocha da Silva, Júlia Délis de Oliveira Rebouças, Vitória Pessoa de Farias Cabral, Daniel Sampaio Rodrigues, Amanda Dias Barbosa, Lara Elloyse Almeida Moreira, Fátima Daiana Dias Barroso, Tatiana do Nascimento Paiva Coutinho, Elaine Aires de Lima, Claudia Roberta de Andrade, João Batista de Andrade Neto, Iri Sandro Pampolha Lima, Hélio Vitoriano Nobre Júnior, Lívia Gurgel do Amaral Valente Sá
Introduction. Candida albicans and Staphylococcus aureus are recognized for their development of resistance and biofilm formation. New therapeutic alternatives are necessary in this context. Hypothesis. Etomidate shows potential application in catheters against mixed biofilms of fluconazole-resistant C. albicans and methicillin-resistant S. aureus (MRSA). Aim. The present study aimed to evaluate the activity of etomidate against mixed biofilms of fluconazole-resistant C. albicans and MRSA. Methodology. The action of etomidate against mature biofilms was verified through the evaluation of biomass and cell viability, and its ability to prevent biofilm formation in peripheral venous catheters was determined based on counts of colony forming units (c...
February 2024: Journal of Medical Microbiology
https://read.qxmd.com/read/38384742/a-novel-zinc-chelating-compound-has-antifungal-activity-against-a-wide-range-of-candida-species-including-multidrug-resistant-candida-auris
#28
JOURNAL ARTICLE
Takayuki Shinohara, Akira Wada, Masahiro Abe, Nobuko Nakayama, Minoru Nagi, Yoshitsugu Miyazaki
OBJECTIVES: In recent years, the incidence of invasive fungal infections has increased, resulting in considerable morbidity and mortality, particularly among immunocompromised individuals. Potential challenges in treating these infections with the few existing antifungal agents highlight the urgency of developing new ones. Here, we evaluated six alkyl polyamine compounds (APCs), not previously reported as antifungal drugs to our knowledge, that could deprive fungi of essential transition metals...
February 2024: JAC-antimicrobial resistance
https://read.qxmd.com/read/38384468/complexation-of-fungal-extracellular-nucleic-acids-by-host-ll-37-peptide-shapes-neutrophil-response-to-candida-albicans-biofilm
#29
JOURNAL ARTICLE
Magdalena Juszczak, Marcin Zawrotniak, Maria Rapala-Kozik
Candida albicans remains the predominant cause of fungal infections, where adhered microbial cells form biofilms - densely packed communities. The central feature of C. albicans biofilms is the production of an extracellular matrix (ECM) consisting of polymers and extracellular nucleic acids (eDNA, eRNA), which significantly impedes the infiltration of host cells. Neutrophils, as crucial players in the innate host defense, employ several mechanisms to eradicate the fungal infection, including NETosis, endocytosis, or the release of granules containing, among others, antimicrobial peptides (AMPs)...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38381075/from-synergy-to-monotherapy-discovery-of-novel-2-4-6-trisubstituted-triazine-hydrazone-derivatives-with-potent-antifungal-potency-in-vitro-and-in-vivo
#30
JOURNAL ARTICLE
Fei Xie, Yumeng Hao, Yu Liu, Junhe Bao, Ruina Wang, Xiaochen Chi, Ting Wang, Shichong Yu, Yongsheng Jin, Liping Li, Yuanying Jiang, Dazhi Zhang, Lan Yan, Tingjunhong Ni
Invasive fungal infections pose a serious threat to public health and are associated with high mortality and incidence rates. The development of novel antifungal agents is urgently needed. Based on hit-to-lead optimization, a series of 2,4,6-trisubstituted triazine hydrazone compounds were designed, synthesized, and biological evaluation was performed, leading to the identification of compound 28 with excellent in vitro synergy (FICI range: 0.094-0.38) and improved monotherapy potency against fluconazole-resistant Candida albicans and Candida auris (MIC range: 1...
February 21, 2024: Journal of Medicinal Chemistry
https://read.qxmd.com/read/38380673/evaluation-of-outbreak-persistence-caused-by-multidrug-resistant-and-echinocandin-resistant-candida-parapsilosis-using-multidimensional-experimental-and-epidemiological-approaches
#31
JOURNAL ARTICLE
Farnaz Daneshnia, Daniel J Floyd, Adam P Ryan, Pegah Mosharaf Ghahfarokhy, Arefeh Ebadati, Sebastian Jusuf, Julieta Munoz, Nathan E Jeffries, Emma Elizabeth Yvanovich, Anna Apostolopoulou, Austin M Perry, Cornelia Lass-Flörl, Asuman Birinci, Süleyha Hilmioğlu-Polat, Macit Ilkit, Geraldine Butler, Clarissa J Nobile, Amir Arastehfar, Michael K Mansour
Candida parapsilosis is known to cause severe and persistent outbreaks in clinical settings. Patients infected with multidrug-resistant C. parapsilosis (MDR Cp) isolates were identified in a large Turkish hospital from 2017-2020. We subsequently identified three additional patients infected with MDR Cp isolates in 2022 from the same hospital and two echinocandin-resistant (ECR) isolates from a single patient in another hospital. The increasing number of MDR and ECR isolates contradicts the general principle that the severe fitness cost associated with these phenotypes could prevent their dominance in clinical settings...
February 21, 2024: Emerging Microbes & Infections
https://read.qxmd.com/read/38379825/use-of-the-fluorescent-dye-thioflavin-t-to-track-amyloid-structures-in-the-pathogenic-yeast-candida-albicans
#32
JOURNAL ARTICLE
Thierry Mourer, Christophe d'Enfert, Sophie Bachellier-Bassi
The human pathogenic yeast Candida albicans can attach to epithelial cells or indwelling medical devices to form biofilms. These microbial communities are highly problematic in the clinic as they reduce both sensitivity to antifungal drugs and detection of fungi by the immune system. Amyloid structures are highly organized quaternary structures that play a critical role in biofilm establishment by allowing fungal cells to adhere to each other. Thus, fungal amyloids are exciting targets to develop new antifungal strategies...
February 5, 2024: Bio-protocol
https://read.qxmd.com/read/38377927/the-aggregation-characteristics-of-aspergillus-spores-under-various-conditions-and-the-impact-on-lpuv-inactivation-comparisons-with-chlorine-based-disinfection
#33
JOURNAL ARTICLE
Zhenghong Zhang, Huan Zhang, Gehui Wu, Xiangqian Xu, Ruihua Cao, Qiqi Wan, Huining Xu, Jingyi Wang, Tinglin Huang, Gang Wen
Aggregation is the primary step prior to fungal biofilm development. Understanding the attributes of aggregation is of great significance to better control the emergence of waterborne fungi. In this study, the aggregation of Aspergills spores (A. flavus and A. fumigatus) under various salt, culture medium, and humic acid (HA) conditions was investigated for the first time, and the inactivation via low-pressure ultraviolet (LPUV) upon aggregated Aspergillus spores was also presented. The aggregation efficiency and size of aggregates increased over time and at low salt (NaCl and CaCl2 ) concentration (10 mM) while decreasing with the continuous increase of salt concentration (100 and 200 mM)...
February 15, 2024: Water Research
https://read.qxmd.com/read/38375518/vitamin-d-3-a-promising-antifungal-and-antibiofilm-agent-against-candida-species
#34
JOURNAL ARTICLE
Zahra Kherad, Somayeh Yazdanpanah, Farshid Saadat, Keyvan Pakshir, Kamiar Zomorodian
BACKGROUND AND PURPOSE: Candida species are opportunistic fungal pathogens that cause mild to life-threatening infections in both immunocompetent and immunocompromised populations. The increasing prevalence of drug-resistant Candida species has posed a significant challenge to the management of infections in clinical settings. Therefore, this study aimed to investigate the direct antifungal and antibiofilm effect of vitamin D3 against Candida species. MATERIALS AND METHODS: The antifungal activity of vitamin D3 was evaluated by broth microdilution method based on the Clinical and Laboratory Standard Institute...
June 2023: Current Medical Mycology
https://read.qxmd.com/read/38367023/cell-free-supernatants-of-probiotic-consortia-impede-hyphal-formation-and-disperse-biofilms-of-vulvovaginal-candidiasis-causing-candida-in-an-ex-vivo-model
#35
JOURNAL ARTICLE
Sudaarsan Aruna Senthil Kumar, Dhesiga Krishnan, Sowndarya Jothipandiyan, Ramyadevi Durai, B Narayanan Vedha Hari, Paramasivam Nithyanand
Vulvovaginal candidiasis is the second most common vaginal infection caused by drug-resistant Candida species that affects about 70-75% of reproductive age group women across the globe. As current-day antifungal drugs are ineffective against the biofilms formed by the drug-resistant Candida strains, several natural compounds and antagonistic microbes are being explored as alternative antifungal agents. In the present study, we investigated the anti-biofilm activity of Cell-Free Supernatant (CFS) extracted from the commercially available probiotics VSL-3 against the biofilms of Candida species and also evaluated their efficacy in curbing the yeast-to-hyphal transition...
February 17, 2024: Antonie Van Leeuwenhoek
https://read.qxmd.com/read/38364932/oxymatrine-mitigates-aspergillus-fumigatus-keratitis-by-suppressing-fungal-activity-and-restricting-pyroptosis
#36
JOURNAL ARTICLE
Weichen Liu, Xue Tian, Lingwen Gu, Bing Yu, Ziyi Wang, Menghui Chi, Jing Lin, Qian Wang, Guibo Liu, Guiqiu Zhao, Cui Li
Fungal keratitis (FK) is a refractory keratitis caused by excessive inflammation and fungal damage. Excessive inflammation can lead to tissue damage and corneal opacity, resulting in a poor prognosis for FK. Oxymatrine (OMT) is a natural alkaloid, which has rich pharmacological effects, such as antioxidant and anti-inflammation. However, its antifungal activity and the mechanism of action in FK have not been elucidated. This study confirmed that OMT suppressed Aspergillus fumigatus growth, biofilm formation, the integrity of fungal cell and conidial adherence...
February 14, 2024: Experimental Eye Research
https://read.qxmd.com/read/38363376/effects-of-different-light-wavelengths-on-bacillus-subtilis-and-bacillus-velezensis-two-biocontrol-agents-isolated-from-the-maize-phyllosphere
#37
JOURNAL ARTICLE
Aluminé Fessia, Rodrigo Ponzio, Luciana Arcibia, Germán Barros, Andrea Nesci
In previous studies, two strains isolated from the maize phyllosphere were identified as Bacillus subtilis (EM-A7) and Bacillus velezensis (EM-A8) and selected as potential biocontrol agents against Exserohilum turcicum. This study aimed to assess the ability of EM-A7 and EM-A8 to form biofilm and have antagonistic activity under varying light conditions. LED sources were custom-designed so that each corresponded to a given spectrum at a specific photosynthetically active photon flux density. Significant differences were observed in growth parameters (generation time and constant growth rate) under different LED sources...
February 16, 2024: Archives of Microbiology
https://read.qxmd.com/read/38357342/effects-of-increasing-drip-irrigation-at-different-maize-growth-stages-on-soil-microorganisms
#38
JOURNAL ARTICLE
Lei Wang, Xiaojuan Wang, Tianle Wang
INTRODUCTION: To investigate the effects of different drip irrigation periods on soil microbial communities and functions. METHODS: Increasing drip irrigation amount at the seedling (S), jointing (J), bell (B), tasseling (T) and grain filling (G) stages of maize were studied using no increase in irrigation amount as control (CK). Principal component analysis was conducted to comprehensively evaluate soil microbial quality following the different drip irrigation treatments...
2024: Frontiers in Microbiology
https://read.qxmd.com/read/38351796/cytotoxic-polyhydroxy-isoprenoids-from-neodidymelliopsis-negundinis
#39
JOURNAL ARTICLE
Patcharee Pripdeevech, Sarunpron Khruengsai, Chutima Tanapichatsakul, Wael M Afifi, Winnie Chemutai Sum, Kevin D Hyde, Sherif S Ebada
Fungal-derived natural products continue to play a pivotal role in the discovery of drug agents for human, veterinary, and general agricultural use. The fungus Neodidymelliopsis negundinis presents a significant saprobic ascomycete whose metabolites remained hitherto unstudied. Herein we report the isolation of eight unprecedented secondary metabolites named neodidymelliosides A and B ( 1 and 2 ), neodidymelliol A ( 3 ), and neodidymellioic acids A-E ( 4 - 8 ) produced by the submerged cultures of the fungus...
February 13, 2024: Journal of Natural Products
https://read.qxmd.com/read/38349550/use-of-aureobasidium-in-a-sustainable-economy
#40
REVIEW
Stephanie Rensink, Elke J van Nieuwenhuijzen, Michael F Sailer, Christian Struck, Han A B Wösten
Aureobasidium is omnipresent and can be isolated from air, water bodies, soil, wood, and other plant materials, as well as inorganic materials such as rocks and marble. A total of 32 species of this fungal genus have been identified at the level of DNA, of which Aureobasidium pullulans is best known. Aureobasidium is of interest for a sustainable economy because it can be used to produce a wide variety of compounds, including enzymes, polysaccharides, and biosurfactants. Moreover, it can be used to promote plant growth and protect wood and crops...
February 13, 2024: Applied Microbiology and Biotechnology
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