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https://www.readbyqxmd.com/read/29163441/antifungal-and-anti-biofilm-activity-of-essential-oil-active-components-against-cryptococcus-neoformans-and-cryptococcus-laurentii
#1
Poonam Kumari, Rutusmita Mishra, Neha Arora, Apurva Chatrath, Rashmi Gangwar, Partha Roy, Ramasare Prasad
Cryptococcosis is an emerging and recalcitrant systemic infection occurring in immunocompromised patients. This invasive fungal infection is difficult to treat due to the ability of Cryptococcus neoformans and Cryptococcus laurentii to form biofilms resistant to standard antifungal treatment. The toxicity concern of these drugs has stimulated the search for natural therapeutic alternatives. Essential oil and their active components (EO-ACs) have shown to possess the variety of biological and pharmacological properties...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29163396/synergistic-antifungal-effect-of-fluconazole-combined-with-licofelone-against-resistant-candida-albicans
#2
Xinning Liu, Tao Li, Decai Wang, Yilei Yang, Wenwen Sun, Jianqiao Liu, Shujuan Sun
Candida albicans (C. albicans) is one of the important opportunistic fungal pathogens that is closely associated with disseminated or chronic infections. The objective of this study is to evaluate the synergistic antifungal effect of licofelone, which is dual microsomal prostaglandin E2 synthase/lipoxygenase (mPGES-1/LOX) inhibitor in combination with fluconazole against C. albicans. Here our results showed that licofelone (16 μg/mL) can synergistically work with fluconazole (1 μg/mL) against planktonic cells of fluconazole-resistant C...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29163377/wild-grape-associated-yeasts-as-promising-biocontrol-agents-against-vitis-vinifera-fungal-pathogens
#3
Gustavo Cordero-Bueso, Nicola Mangieri, David Maghradze, Roberto Foschino, Federica Valdetara, Jesús M Cantoral, Ileana Vigentini
The increasing level of hazardous residues in the environment and food chains has led the European Union to restrict the use of chemical fungicides. Thus, exploiting new natural antagonistic microorganisms against fungal diseases could serve the agricultural production to reduce pre- and post-harvest losses, to boost safer practices for workers and to protect the consumers' health. The main aim of this work was to evaluate the antagonistic potential of epiphytic yeasts against Botrytis cinerea, Aspergillus carbonarius, and Penicillium expansum pathogen species...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29152581/the-candida-albicans-tor-activating-gtpases-gtr1-and-rhb1-coregulate-starvation-responses-and-biofilm-formation
#4
Peter R Flanagan, Ning-Ning Liu, Darren J Fitzpatrick, Karsten Hokamp, Julia R Köhler, Gary P Moran
Target of rapamycin complex 1 (TORC1) is an essential regulator of metabolism in eukaryotic cells and in the fungal pathogen Candida albicans regulates morphogenesis and nitrogen acquisition. Gtr1 encodes a highly conserved GTPase that in Saccharomyces cerevisiae regulates nitrogen sensing and TORC1 activation. Here, we characterize the role of C. albicans GTR1 in TORC1 activation and compare it with the previously characterized GTPase Rhb1. A homozygous gtr1/gtr1 mutant exhibited impaired TORC1-mediated phosphorylation of ribosomal protein S6 and increased susceptibility to rapamycin...
November 2017: MSphere
https://www.readbyqxmd.com/read/29146260/a-novel-burkholderia-ambifaria-strain-able-to-degrade-the-mycotoxin-fusaric-acid-and-to-inhibit-fusarium-spp-growth
#5
Ester Simonetti, Irma N Roberts, Marcela S Montecchia, Flavio H Gutierrez-Boem, Federico M Gomez, Jimena A Ruiz
Fusaric acid (FA) is a fungal metabolite produced by several Fusarium species responsible for wilts and root rot diseases of a great variety of plants. Bacillus spp. and Pseudomonas spp. have been considered as promising biocontrol agents against phytopathogenic Fusarium spp., however it has been demonstrated that FA negatively affects growth and production of some antibiotics in these bacteria. Thus, the capability to degrade FA would be a desirable characteristic in bacterial biocontrol agents of Fusarium wilt...
January 2018: Microbiological Research
https://www.readbyqxmd.com/read/29137671/herpes-simplex-virus-1-entrapped-in-candida-albicans-biofilm-displays-decreased-sensitivity-to-antivirals-and-uva1-laser-treatment
#6
Cristian Ascione, Arianna Sala, Elham Mazaheri-Tehrani, Simona Paulone, Beniamino Palmieri, Elisabetta Blasi, Claudio Cermelli
BACKGROUND: Recently, we published data suggesting a mutualistic relationship between HSV-1 and Candida. albicans; in particular: (a) HSV-1 infected macrophages are inhibited in their anti-Candida effector function and (b) Candida biofilm protects HSV-1 from inactivation. The present in vitro study is aimed at testing the effects of Candida biofilm on HSV-1 sensitivity to pharmacological and physical stress, such as antiviral drugs (acyclovir and foscarnet) and laser UVA1 irradiation...
November 14, 2017: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/29135948/effect-of-a-lactobacillus-salivarius-probiotic-on-a-double-species-streptococcus-mutans-and-candida-albicans-caries-biofilm
#7
Wirginia Krzyściak, Dorota Kościelniak, Monika Papież, Palina Vyhouskaya, Katarzyna Zagórska-Świeży, Iwona Kołodziej, Beata Bystrowska, Anna Jurczak
The aim of the study was to evaluate the anti-cariogenic effects of Lactobacillus salivarius by reducing pathogenic species and biofilm mass in a double-species biofilm model. Coexistence of S. mutans with C. albicans can cause dental caries progression or recurrence of the disease in the future. Fifty-nine children with diagnosed early childhood caries (ECC) were recruited onto the study. The condition of the children's dentition was defined according to the World Health Organization guidelines. The participants were divided into children with initial enamel demineralization and children showing dentin damage...
November 14, 2017: Nutrients
https://www.readbyqxmd.com/read/29134404/curcumin-mediated-anti-microbial-photodynamic-therapy-against-candida-dubliniensis-biofilms
#8
Paula Volpato Sanitá, Ana Cláudia Pavarina, Lívia Nordi Dovigo, Ana Paula Dias Ribeiro, Mariana Carvalho Andrade, Ewerton Garcia de Oliveira Mima
The purpose of this study was to evaluate the effectiveness of anti-microbial photodynamic therapy (aPDT) mediated by curcumin (Cur) associated with LED light against biofilms of Candida dubliniensis, and further, investigate cellular uptake and drug penetration through the biofilms under confocal laser scanning microscopy (CLSM). Four C. dubliniensis strains were tested: three clinical isolates from HIV-positive patients and one reference strain (CBS 7987). Biofilms were treated with three Cur concentrations (20...
November 13, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/29133157/microbiological-and-clinical-characteristics-of-biofilm-forming-candida-parapsilosis-isolates-associated-with-fungaemia-and-their-impact-on-mortality
#9
Silvia Soldini, Brunella Posteraro, Antonietta Vella, Elena De Carolis, Elisa Borghi, Monica Falleni, Angela Raffaella Losito, Giuseppe Maiuro, Enrico Maria Trecarichi, Maurizio Sanguinetti, Mario Tumbarello
OBJECTIVES: Biofilm formation (BF) by fungal isolates may dramatically complicate infection. We determined the ability of C. parapsilosis isolates from single fungaemia episodes to form biofilms and we analysed biofilm subgroups for antifungal susceptibility and pathogenic potential. We then correlated BF with clinical characteristics and outcomes of the episodes. METHODS: BF was measured using the crystal-violet biomass assay, antifungal susceptibility of preformed biofilms was assessed, and virulence was studied using the Galleria mellonella model...
November 10, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29126739/discovery-of-simplified-sampangine-derivatives-as-novel-fungal-biofilm-inhibitors
#10
Na Liu, Hua Zhong, Jie Tu, Zhigan Jiang, Yanjuan Jiang, Yan Jiang, Yuanying Jiang, Jian Li, Wannian Zhang, Yan Wang, Chunquan Sheng
Lack of novel antifungal agents and severe drug resistance have led to high incidence and associated mortality of invasive fungal infections. To tackle the challenges, novel antifungal agents with new chemotype, fungicidal activity and anti-resistant potency are highly desirable. On the basis of our previously identified simplified analogue of antifungal natural product sampangine, systemic structure-activity relationships were clarified and two novel derivatives showed promising features as novel antifungal lead compounds...
October 16, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29123396/use-of-magnetic-nanoparticles-as-a-drug-delivery-system-to-improve-chlorhexidine-antimicrobial-activity
#11
Grażyna Tokajuk, Katarzyna Niemirowicz, Piotr Deptuła, Ewelina Piktel, Mateusz Cieśluk, Agnieszka Z Wilczewska, Jan R Dąbrowski, Robert Bucki
Nanotechnology offers new tools for developing therapies to prevent and treat oral infections, particularly biofilm-dependent disorders, such as dental plaques and endodontic and periodontal diseases. Chlorhexidine (CHX) is a well-characterized antiseptic agent used in dentistry with broad spectrum activity. However, its application is limited due to inactivation in body fluid and cytotoxicity toward human cells, particularly at high concentrations. To overcome these limitations, we synthesized nanosystems composed of aminosilane-coated magnetic nanoparticles functionalized with chlorhexidine (MNP@CHX)...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29111321/inhibition-activity-of-lactobacilli-supernatant-against-fungal-bacterial-multispecies-biofilms-on-silicone
#12
Yulong Tan, Matthias Leonhard, Doris Moser, Berit Schneider-Stickler
Fungal-bacterial multispecies biofilms play a major role in failure of medical silicone devices, such as voice prostheses in laryngectomiy. In this study, we determined the effect of Lactobacilli supernatant (cell free) on mixed biofilm formation of fungi and bacteria on silicone in vitro. Lactobacilli supernatant inhibited the adhesion (90 min) of mixed fungi and bacteria species with an efficiency of >90%. Mixed biofilm formation and the metabolic activity of the biofilms were inhibited by 72.23% and 58...
October 28, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29107946/yeast-casein-kinase-2-governs-morphology-biofilm-formation-cell-wall-integrity-and-host-cell-damage-of-candida-albicans
#13
Sook-In Jung, Natalie Rodriguez, Jihyun Irrizary, Karl Liboro, Thania Bogarin, Marlene Macias, Edward Eivers, Edith Porter, Scott G Filler, Hyunsook Park
The regulatory networks governing morphogenesis of a pleomorphic fungus, Candida albicans are extremely complex and remain to be completely elucidated. This study investigated the function of C. albicans yeast casein kinase 2 (CaYck2p). The yck2Δ/yck2Δ strain displayed constitutive pseudohyphae in both yeast and hyphal growth conditions, and formed enhanced biofilm under non-biofilm inducing condition. This finding was further supported by gene expression analysis of the yck2Δ/yck2Δ strain which showed significant upregulation of UME6, a key transcriptional regulator of hyphal transition and biofilm formation, and cell wall protein genes ALS3, HWP1, and SUN41, all of which are associated with morphogenesis and biofilm architecture...
2017: PloS One
https://www.readbyqxmd.com/read/29104569/a-linear-19-mer-plant-defensin-derived-peptide-acts-synergistically-with-caspofungin-against-candida-albicans-biofilms
#14
Tanne L Cools, Caroline Struyfs, Jan W Drijfhout, Soňa Kucharíková, Celia Lobo Romero, Patrick Van Dijck, Marcelo H S Ramada, Carlos Bloch, Bruno P A Cammue, Karin Thevissen
Public health problems are associated with device-associated biofilm infections, with Candida albicans being the major fungal pathogen. We previously identified potent antibiofilm combination treatment in which the antifungal plant defensin HsAFP1 is co-administered with caspofungin, the preferred antimycotic to treat such infections. In this study, we identified the smallest linear HsAFP1-derived peptide that acts synergistically with caspofungin or anidulafungin against C. albicans as HsLin06_18, a 19-mer peptide derived from the C-terminal part of HsAFP1...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29099084/essential-oils-and-antifungal-activity
#15
REVIEW
Filomena Nazzaro, Florinda Fratianni, Raffaele Coppola, Vincenzo De Feo
Since ancient times, folk medicine and agro-food science have benefitted from the use of plant derivatives, such as essential oils, to combat different diseases, as well as to preserve food. In Nature, essential oils play a fundamental role in protecting the plant from biotic and abiotic attacks to which it may be subjected. Many researchers have analyzed in detail the modes of action of essential oils and most of their components. The purpose of this brief review is to describe the properties of essential oils, principally as antifungal agents, and their role in blocking cell communication mechanisms, fungal biofilm formation, and mycotoxin production...
November 2, 2017: Pharmaceuticals
https://www.readbyqxmd.com/read/29081766/an-update-on-candida-tropicalis-based-on-basic-and-clinical-approaches
#16
REVIEW
Diana L Zuza-Alves, Walicyranison P Silva-Rocha, Guilherme M Chaves
Candida tropicalis has emerged as one of the most important Candida species. It has been widely considered the second most virulent Candida species, only preceded by C. albicans. Besides, this species has been recognized as a very strong biofilm producer, surpassing C. albicans in most of the studies. In addition, it produces a wide range of other virulence factors, including: adhesion to buccal epithelial and endothelial cells; the secretion of lytic enzymes, such as proteinases, phospholipases, and hemolysins, bud-to-hyphae transition (also called morphogenesis) and the phenomenon called phenotypic switching...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29076804/chain-length-specific-anti-candida-activity-of-cationic-lipo-oxazoles-a-new-class-of-quaternary-ammonium-compounds
#17
Tushar Jain, Pratap Reddy Muktapuram, Satyanarayana Pochampalli, Komal Sharma, Garima Pant, Kalyan Mitra, Surendar Reddy Bathula, Dibyendu Banerjee
PURPOSE: Candida species have become resistant to commonly used anti-fungal drugs like fluconazole and echinocandins. In our screen, a series of quaternary ammonium compounds (QACs) emerged as an alternative treatment choice for drug-resistant Candida infections. METHODOLOGY: Medium alkyl chain cationic lipo-oxazoles comprising six to thirteen twin carbon chains and a quaternary ammonium unit were synthesized and evaluated for their in vitro anti-Candida and biofilm inhibition activity...
October 27, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29074435/the-natural-compound-magnolol-affects-growth-biofilm-formation-and-ultrastructure-of-oral-candida-isolates
#18
Jawad Behbehani, Sheikh Shreaz, Mohammad Irshad, Maribassapa Karched
The incidence of oral candidosis has increased in recent years due to the escalation in HIV-infection, cancer treatments, organ transplantation, and diabetes. In addition, corticosteroid use, dentures, and broad-spectrum antibiotic use have also contributed to the problem. Treatment of oral candidosis has continued to be problematic because of the potential toxicity of antifungals in clinical use, and, above all, development of drug resistance among patients. In this study, the antifungal effect of magnolol was investigated against 64 strains of Candida spp...
October 23, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29067482/sigma-factor-rpon-employs-a-dual-transcriptional-regulation-for-controlling-twitching-motility-and-biofilm-formation-in-lysobacter-enzymogenes-oh11
#19
Sen Han, Danyu Shen, Yun Zhao, Dan Xu, Jing Liu, Shan-Ho Chou, Fengquan Liu, Guoliang Qian
Lysobacter is a Gram-negative genus comprising a group of environmental bacteria with abilities to produce abundant novel antibiotics, as well as adopting a unique type IV pilus (T4P)-mediated twitching motility (TM) that remains poorly understood. Here, we employ L. enzymogenes OH11 exhibiting significant antifungal activity as a working model to address this issue. Via mutating the 28 potential sigma factors in strain OH11, we have identified one protein RpoNOH11 (sigma 54) that is indispensable for T4P formation and TM...
October 24, 2017: Current Genetics
https://www.readbyqxmd.com/read/29067006/a-multispecies-fungal-biofilm-approach-to-enhance-the-celluloyltic-efficiency-of-membrane-reactors-for-consolidated-bioprocessing-of-plant-biomass
#20
Charilaos Xiros, Michael H Studer
The constraints and advantages in cellulolytic enzymes production by fungal biofilms for a consolidated bioconversion process were investigated during this study. The biofilm cultivations were carried out in reactors designed for consolidated bioprocessing Multispecies Biofilm Membrane reactors, (MBM) where an aerobic fungal biofilm produces the lignocellulolytic enzymes while a fermenting microorganism forms the fermentation product at anaerobic conditions. It was shown that although mycelial growth was limited in the MBM reactors compared to submerged cultivations, the secretion of cellulolytic enzymes per cell dry weight was higher...
2017: Frontiers in Microbiology
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