keyword
https://read.qxmd.com/read/38495880/modulation-of-myeloid-derived-suppressor-cell-functions-by-oral-inflammatory-diseases-and-important-oral-pathogens
#1
REVIEW
Fernando García-Arévalo, Ana Gabriela Leija-Montoya, Javier González-Ramírez, Mario Isiordia-Espinoza, Idanya Serafín-Higuera, Dulce Martha Fuchen-Ramos, J Gustavo Vazquez-Jimenez, Nicolas Serafín-Higuera
The oral cavity presents a diverse microbiota in a dynamic balance with the host. Disruption of the microbial community can promote dysregulation of local immune response which could generate oral diseases. Additionally, alterations in host immune system can result in inflammatory disorders. Different microorganisms have been associated with establishment and progression of the oral diseases. Oral cavity pathogens/diseases can modulate components of the inflammatory response. Myeloid-derived suppressor cells (MDSCs) own immunoregulatory functions and have been involved in different inflammatory conditions such as infectious processes, autoimmune diseases, and cancer...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38494241/unveiling-the-inverse-antimicrobial-impact-of-a-hetero-chitooligosaccharide-on-candida-tropicalis-growth-and-biofilm-formation
#2
JOURNAL ARTICLE
Yangyang Liu, Ruilian Li, Yuchen Zhang, Siming Jiao, Tong Xu, Yuhang Zhou, Yujing Wang, Jinhua Wei, Wei Du, Morihisa Fujita, Yuguang Du, Zhuo A Wang
Chitosan and chitooligosaccharide (COS) are renowned for their potent antimicrobial prowess, yet the precise antimicrobial efficacy of COS remains elusive due to scant structural information about the utilized saccharides. This study delves into the antimicrobial potential of COS, spotlighting a distinct hetero-chitooligosaccharide dubbed DACOS. In contrast to other COS, DACOS remarkably fosters the growth of Candida tropicalis planktonic cells and fungal biofilms. Employing gradient alcohol precipitation, DACOS was fractionated, unveiling diverse structural characteristics and differential impacts on C...
June 1, 2024: Carbohydrate Polymers
https://read.qxmd.com/read/38481158/analysis-of-the-complete-genome-sequence-of-paenibacillus-sp-lzh-n1-reveals-its-antagonistic-ability
#3
JOURNAL ARTICLE
Ee Li, Kaiquan Liu, Shuhan Yang, Ling Li, Kun Ran, Xiaoli Sun, Jie Qu, Li Zhao, Yuxiu Xin, Feng Zhu, Jingfang Ma, Feng Song, Zhenghua Li
BACKGROUND: Plant diseases caused by pathogenic fungi are devastating. However, commonly used fungicides are harmful to the environment, and some are becoming ineffective due to fungal resistance. Therefore, eco-friendly biological methods to control pathogenic fungi are urgently needed. RESULTS: In this study, a strain, Paenibacillus sp. lzh-N1, that could inhibit the growth of the pathogenic fungus Mycosphaerella sentina (Fr) Schrorter was isolated from the rhizosphere soil of pear trees, and the complete genome sequence of the strain was obtained, annotated, and analyzed to reveal the genetic foundation of its antagonistic ability...
March 13, 2024: BMC Genomics
https://read.qxmd.com/read/38477802/anticandida-and-antibiofilm-activities-of-extract-from-schinopsis-brasiliensis-engl-against-candida-spp
#4
JOURNAL ARTICLE
Vanessa de Carvalho Jovito, Jefferson Muniz de Lima, Marianne de Lucena Rangel, Brenna Louise Cavalcanti Gondim, Paula Lima Nogueira, Ana Claúdia Dantas de Medeiros, Marianna Vieira Sobral, Ricardo Dias de Castro, Lúcio Roberto Cançado Castellano
The pathogenic nature of infections caused by Candida spp. underscores the necessity for novel therapeutic agents. Extracts of Schinopsis brasilienses Engl are \ a promising source of agents with antifungal effects. This study aimed to assess the antifungal potential of the leaf extract of S. brasilienses. The antifungal activity was evaluated by determining the minimum inhibitory concentrations and fungicide concentrations (MIC and MFC). The antibiofilm potential was assessed by counting colony-forming units/mL...
2024: Brazilian Oral Research
https://read.qxmd.com/read/38470537/regulatory-features-of-candida-albicans-hemin-induced-filamentation
#5
JOURNAL ARTICLE
Liping Xiong, Katharina Goerlich, Aaron P Mitchell
Candida albicans is a prominent fungal pathogen that can infect the bloodstream and deep tissues. One key pathogenicity trait is the ability to transition between yeast and hyphal growth. Hyphae are critical for the formation of biofilms, which in turn enable device-associated infection. Among signals that drive hypha formation is the presence of hemin, an oxidized Fe(III)-containing heme derivative found in blood. In this study we asked four questions. First, how uniform is the filamentation response to hemin among C...
March 12, 2024: G3: Genes—Genomes—Genetics
https://read.qxmd.com/read/38467906/novel-thiazolinyl-picolinamide-based-palladium-ii-complex-extenuates-the-virulence-and-biofilms-of-vulvovaginal-candidiasis-vvc-causing-candida
#6
JOURNAL ARTICLE
Munieswaran Gayatri, Sowndarya Jothipandiyan, Mohamed Khalid Abdul Azeez, Murugesan Sudharsan, Devarajan Suresh, Paramasivam Nithyanand
Candida infections are growing all over the world as a result of their resistance to anti-fungal drugs. This raises concerns about public health, particularly in cases of vulvovaginal candidiasis (VVC). Therefore, the need for effective treatment options for Candida infections has become crucial. The main goal of the study is to evaluate the efficacy of novel palladium metal complexes against fluconazole-resistant Candida spp., particularly C. albicans and C. auris. The process begins with identifying the minimum inhibitory concentration (MIC), followed by growth curve assays, colony morphology analysis, characterization, and gene expression analysis...
March 11, 2024: International Microbiology: the Official Journal of the Spanish Society for Microbiology
https://read.qxmd.com/read/38459502/unveiling-biological-activities-of-biosynthesized-starch-silver-selenium-nanocomposite-using-cladosporium-cladosporioides-cbs-174-62
#7
JOURNAL ARTICLE
Fathy M Elkady, Amr H Hashem, Salem S Salem, Gharieb S El-Sayyad, Ahmed Abdel Tawab, Mohammad M Alkherkhisy, Mohammed S Abdulrahman
BACKGROUND AND OBJECTIVES: Microbial cells capability to tolerate the effect of various antimicrobial classes represent a major worldwide health concern. The flexible and multi-components nanocomposites have enhanced physicochemical characters with several improved properties. Thus, different biological activities of biosynthesized starch/silver-selenium nanocomposite (St/Ag-Se NC) were assessed. METHODOLOGY: The St/Ag-Se NC was biosynthesized using Cladosporium cladosporioides CBS 174...
March 8, 2024: BMC Microbiology
https://read.qxmd.com/read/38458677/investigation-of-the-antibacterial-activity-of-benziothiazolinone-against-xanthomonas-oryzae-pv-oryzae
#8
JOURNAL ARTICLE
Xing Chen, Chaoyue Pang, Xueqiao Liu, Jiazhi Sun, Ling Jin, Yang Sun, Yu Chen
Plant pathogenic bacteria can cause numerous diseases for higher plants and result in severe reduction of crop yield. Introduction of new bactericides can always effectively control these plant diseases. Benziothiazolinone (BIT) is a novel fungicide registered in China for the control of plant fungal diseases, however, its anti-bacterial activity is not well studied. The results of activity tests showed that BIT exhibited stronger inhibitory activity against bacteria, particularly for Xanthomonas oryzae pv...
February 2024: Pesticide Biochemistry and Physiology
https://read.qxmd.com/read/38453640/mechanophysical-and-anti-adhesive-properties-of-a-nanoclay-containing-pmma-denture-resin
#9
JOURNAL ARTICLE
Jun-Yong Ahn, Yu-Jin Kim, Jung-Hwan Lee, Rajendra K Singh, Hae-Hyoung Lee
Poly(methyl methacrylate) (PMMA) is commonly used for dental dentures, but it has the drawback of promoting oral health risks due to oral bacterial adhesion. Recently, various nanoparticles have been incorporated into PMMA to tackle these issues. This study aims to investigate the mechanophysical and antimicrobial adhesive properties of a denture resin by incorporating of nanoclay into PMMA. Specimens were prepared by adding 0, 1, 2, and 4 wt % surface-modified nanoclay (Sigma) to self-polymerizing PMMA denture resin...
March 7, 2024: ACS Biomaterials Science & Engineering
https://read.qxmd.com/read/38452422/a-metabolomics-footprinting-approach-using-gc-ms-to-study-inhibitory-effects-of-the-fungal-metabolite-diplopyrone-c-against-nosocomial-pathogen-biofilms
#10
JOURNAL ARTICLE
Maria Michela Salvatore, Angela Maione, Marianna Imparato, Francesco Salvatore, Marco Guida, Emilia Galdiero, Anna Andolfi
Seen initially as wonder drugs, the widespread and often inappropriate use of antibiotics led to the development of microbial resistances. As a result, a true emergency has arisen, and a significant need has emerged to discover and develop new safe and valuable antibiotics. The captivating chemical structure of the fungal metabolite diplopyrone C has caught our attention as an excellent candidate for a circumstantial study aimed at revealing its antimicrobial and antibiofilm activities. In this work, we describe the full analytical strategy from the isolation/identification to the evaluation of the metabolomics effect on target microorganisms of this fungal metabolite...
March 2, 2024: Journal of Pharmaceutical and Biomedical Analysis
https://read.qxmd.com/read/38446770/studying-mixed-species-biofilms-of-candida-albicans-and-staphylococcus-aureus-using-evolutionary-game-theory
#11
JOURNAL ARTICLE
Sybille Dühring, Stefan Schuster
Mixed-species biofilms of Candida albicans and Staphylococcus aureus pose a significant clinical challenge due to their resistance to the human immune system and antimicrobial therapy. Using evolutionary game theory and nonlinear dynamics, we analyse the complex interactions between these organisms to understand their coexistence in the human host. We determine the Nash equilibria and evolutionary stable strategies of the game between C. albicans and S. aureus and point out different states of the mixed-species biofilm...
2024: PloS One
https://read.qxmd.com/read/38440972/comparative-transcriptional-analysis-of-candida-auris-biofilms-following-farnesol-and-tyrosol-treatment
#12
JOURNAL ARTICLE
Ágnes Jakab, Fruzsina Kovács, Noémi Balla, Csaba Nagy-Köteles, Ágota Ragyák, Fruzsina Nagy, Andrew M Borman, László Majoros, Renátó Kovács
UNLABELLED: Candida auris is frequently associated with biofilm-related invasive infections. The resistant profile of these biofilms necessitates innovative therapeutic options, where quorum sensing may be a potential target. Farnesol and tyrosol are two fungal quorum-sensing molecules with antifungal effects at supraphysiological concentrations. Here, we performed genome-wide transcript profiling with C. auris biofilms following farnesol or tyrosol exposure using transcriptome sequencing (RNA-Seq)...
March 5, 2024: Microbiology Spectrum
https://read.qxmd.com/read/38434581/remodeling-of-paranasal-sinuses-mucosa-functions-in-response-to-biofilm-induced-inflammation
#13
REVIEW
Szczepan Kaliniak, Krzysztof Fiedoruk, Jakub Spałek, Ewelina Piktel, Bonita Durnaś, Stanisław Góźdź, Robert Bucki, Sławomir Okła
Rhinosinusitis (RS) is an acute (ARS) or chronic (CRS) inflammatory disease of the nasal and paranasal sinus mucosa. CRS is a heterogeneous condition characterized by distinct inflammatory patterns (endotypes) and phenotypes associated with the presence (CRSwNP) or absence (CRSsNP) of nasal polyps. Mucosal barrier and mucociliary clearance dysfunction, inflammatory cell infiltration, mucus hypersecretion, and tissue remodeling are the hallmarks of CRS. However, the underlying factors, their priority, and the mechanisms of inflammatory responses remain unclear...
2024: Journal of Inflammation Research
https://read.qxmd.com/read/38433891/importance-of-quorum-sensing-crosstalk-in-the-brown-alga-saccharina-latissima-epimicrobiome
#14
JOURNAL ARTICLE
Emilie Adouane, Camille Mercier, Jeanne Mamelle, Emma Willocquet, Laurent Intertaglia, Bertille Burgunter-Delamare, Catherine Leblanc, Sylvie Rousvoal, Raphaël Lami, Soizic Prado
Brown macroalgae are colonized by diverse microorganisms influencing the physiology of their host. However, cell-cell interactions within the surface microbiome (epimicrobiome) are largely unexplored, despite the significance of specific chemical mediators in maintaining host-microbiome homeostasis. In this study, by combining liquid chromatography coupled to mass spectrometry (LC-MS) analysis and bioassays, we demonstrated that the widely diverse fungal epimicrobiota of the brown alga Saccharina latissima can affect quorum sensing (QS), a type of cell-cell interaction, as well as bacterial biofilm formation...
March 15, 2024: IScience
https://read.qxmd.com/read/38430681/borneol-serves-as-an-adjuvant-agent-to-promote-the-cellular-uptake-of-curcumin-for-enhancing-its-photodynamic-fungicidal-efficacy-against-candida-albicans
#15
JOURNAL ARTICLE
Zhenlong Zhou, Shengli Wang, Penghui Fan, Xiaofeng Meng, Xinyu Cai, Wen Wang, Lin Ma, Hang Ma, Jianyu Su
Candida albicans (C. albicans), a major opportunistic pathogenic fungus, is known to cause superficial skin infections. Unfortunately, the misuse of antibiotics has led to the emergence of drug resistance in fungi. Antimicrobial photodynamic therapy (aPDT), a non-antibiotic alternative, has shown potential in treating drug-resistant fungal infections. Curcumin is a photodynamically active phytochemical whose photodynamic fungicidal efficacy is largely dependent on its intracellular accumulation. However, curcumin faces challenges in penetrating the cytoplasm due to its poor water solubility and the fungal cell wall...
February 26, 2024: Journal of Photochemistry and Photobiology. B, Biology
https://read.qxmd.com/read/38417885/a-silkworm-infection-model-for-evaluating-in-vivo-biofilm-formation-by-pathogenic-fungi
#16
JOURNAL ARTICLE
Yasuhiko Matsumoto, Shintaro Eshima, Sanae Kurakado, Takashi Sugita
Experimental animal models are necessary for research on infectious diseases. Generally, mammalian animals, such as mice, are used for infection experiments. However, there are ethical issues associated with conducting infection experiments in mammals. This has made it difficult to perform infection experiments with a large number of individuals. The invertebrate silkworm, Bombyx mori, is gaining attention as a model animal for infection experiments, and silkworm infection models with various pathogens have been established...
2024: Medical Mycology Journal
https://read.qxmd.com/read/38415658/transdermal-administration-of-farnesol-ethosomes-enhances-the-treatment-of-cutaneous-candidiasis-induced-by-candida-albicans-in-mice
#17
JOURNAL ARTICLE
Ting Shen, Baocheng Tian, Wei Liu, Xuesong Yang, Qi Sheng, Mengxin Li, Haiyan Wang, Xiuwen Wang, Huihui Zhou, Yanchun Han, Chen Ding, Sixiang Sai
UNLABELLED: Cutaneous candidiasis, caused by Candida albicans , is a severe and frustrating condition, and finding effective treatments can be challenging. Therefore, the development of farnesol-loaded nanoparticles is an exciting breakthrough. Ethosomes are a novel transdermal drug delivery carrier that incorporates a certain concentration (10-45%) of alcohols into lipid vesicles, resulting in improved permeability and encapsulation rates compared to conventional liposomes. Farnesol is a quorum-sensing molecule involved in morphogenesis regulation in C...
February 28, 2024: Microbiology Spectrum
https://read.qxmd.com/read/38414644/identification-of-the-toxin-components-of-rhizoctonia-solani-ag1-ia-and-its-destructive-effect-on-plant-cell-membrane-structure
#18
JOURNAL ARTICLE
Shanshan Xu, Shaofeng Ren, Wenjing Bao, Xiaoguang Li, Yumei Zhang, Buzhu Yu, Weiqi Li, Chengyun Li, Wenhan Dong, Genhua Yang
Rice sheath blight is a fungal disease caused mainly by Rhizoctonia solani AG1-IA. Toxins are a major pathogenic factor of R. solani , and some studies have reported their toxin components; however, there is no unified conclusion. In this study, we reported the toxin components and their targets that play a role in R. solani AG1-IA. First, toxins produced by R. solani AG1-IA were examined. Several important phytotoxins, including benzoic acid (BZA), 5-hydroxymethyl-2-furanic aid (HFA), and catechol (CAT), were identified by comparative analysis of secondary metabolites from AG1-IA, AG1-IB, and healthy rice...
2024: Frontiers in Plant Science
https://read.qxmd.com/read/38401680/biotic-and-abiotic-factors-interplay-in-structuring-the-dynamics-of-microbial-co-occurrence-patterns-in-tropical-mountainsides
#19
JOURNAL ARTICLE
Hao Wu, Tianheng Gao, Francisco Dini-Andreote, Nengwen Xiao, Lu Zhang, Ismael Aaron Kimirei, Jianjun Wang
Ecological interactions are important for maintaining biodiversity and ecosystem functions. Particularly in stream biofilms, little is known about the distributional patterns of different taxonomic groups and their potential interactions along elevational gradients. Here, we investigated the bacterial and fungal community structures of stream biofilms across elevational gradients on Mount Kilimanjaro, and explored patterns of their distribution, diversity, community structures, and taxa co-occurrence. We found that fungal and bacterial richness were more convergent at higher elevations, while their community structures became significantly more divergent...
February 22, 2024: Environmental Research
https://read.qxmd.com/read/38399762/identification-of-flo11-like-adhesin-in-schizosaccharomyces-pombe-and-the-mechanism-of-small-molecule-compounds-mediating-biofilm-formation-in-yeasts
#20
JOURNAL ARTICLE
Yu-Gang Zhang, Tong Zhang, Lan Lin
Fungal infection is initiated by the adhesion of pathogens to biotic and abiotic surfaces, with various manifestations including biofilm formation and invasive growth, etc. A previous report, though devoid of functional data, speculated that the Schizosaccharomyces pombe glycoprotein SPBPJ4664.02 could be the homology of Saccharomyces cerevisiae Flo11. Here, our studies with S. pombe substantiated the previously proposed speculation by (1) the deletion of SPBPJ4664.02 attenuated biofilm formation and invasive growth in S...
February 9, 2024: Microorganisms
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