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https://www.readbyqxmd.com/read/28534905/antimicrobial-peptide-inspired-nh125-analogues-bacterial-and-fungal-biofilm-eradicating-agents-and-rapid-killers-of-mrsa-persisters
#1
Akash Basak, Yasmeen Abouelhassan, Ran Zuo, Hussain Yousaf, Yousong Ding, Robert W Huigens
During microbial infection, antimicrobial peptides are utilized by the immune response to rapidly eradicate microbial pathogens through the destruction of cellular membranes. Inspired by antimicrobial peptides, quaternary ammonium cationic (QAC) compounds have emerged as agents capable of destroying bacterial membranes leading to rapid bacterial death, including the eradication of persistent, surface-attached bacterial biofilms. NH125, an imidazolium cation with a sixteen membered fatty tail, was recently reported to eradicate persister cells and was our starting point for the development of novel antimicrobial agents...
May 23, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28526091/a-pre-therapeutic-coating-for-medical-devices-that-prevents-the-attachment-of-candida-albicans
#2
Diego Vargas-Blanco, Aung Lynn, Jonah Rosch, Rony Noreldin, Anthony Salerni, Christopher Lambert, Reeta P Rao
BACKGROUND: Hospital acquired fungal infections are defined as "never events"-medical errors that should never have happened. Systemic Candida albicans infections results in 30-50% mortality rates. Typically, adhesion to abiotic medical devices and implants initiates such infections. Efficient adhesion initiates formation of aggressive biofilms that are difficult to treat. Therefore, inhibitors of adhesion are important for drug development and likely to have a broad spectrum efficacy against many fungal pathogens...
May 19, 2017: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/28516088/the-candida-albicans-biofilm-matrix-composition-structure-and-function
#3
Christopher G Pierce, Taissa Vila, Jesus A Romo, Daniel Montelongo-Jauregui, Gina Wall, Anand Ramasubramanian, Jose L Lopez-Ribot
A majority of infections caused by Candida albicans-the most frequent fungal pathogen-are associated with biofilm formation. A salient feature of C. albicans biofilms is the presence of the biofilm matrix. This matrix is composed of exopolymeric materials secreted by sessile cells within the biofilm, in which all classes of macromolecules are represented, and provides protection against environmental challenges. In this review, we summarize the knowledge accumulated during the last two decades on the composition, structure, and function of the C...
March 2017: Journal of Fungi (Basel, Switzerland)
https://www.readbyqxmd.com/read/28515716/antifungal-activity-of-the-biphosphinic-cyclopalladate-c7a-against-candida-albicans-yeast-forms-in-vitro-and-in-vivo
#4
Julian E Muñoz, Diego C P Rossi, Kelly Ishida, Cristina C Spadari, Marcia S C Melhem, Daniel M Garcia, Antonio C F Caires, Carlos P Taborda, Elaine G Rodrigues
Vulvovaginal and invasive candidiasis are frequent conditions in immunosuppressed individuals caused by Candida albicans and non-albicans Candida spp. Fluconazole and Amphotericin B are the main drugs used to fight the infection. However, resistance to fluconazole and other azole antifungal drugs is an important clinical problem that encourages the search for new therapeutic alternatives. In this work, we evaluate the antifungal activity of the biphosphinic cyclopalladate C7a in the in vitro and in vivo model...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28513096/is-the-oral-fungal-pathogen-candida-albicans-a-cariogen
#5
REVIEW
Daniel Freitas Alves Pereira, Chaminda Jayampath Seneviratne, Cristiane Yumi Koga-Ito, Lakshman Perera Samaranayake
Pathobiology of dental caries is complex. Data from recent molecular microbiologic studies have further redefined the role of the oral microbiome in the etiology of dental caries. This new information challenges the conventional view on the hegemony of classic cariogenic prokaryotes such as Streptococcus mutans in caries aetiology, and raises the intriguing possibility of the participation of the eukaryotic oral fungal pathogen Candida in the caries process. The virulence attributes of Candida species such as their acidogenicity and aciduric nature, the ability to develop profuse biofilms, ferment and assimilate dietary sugars, and produce collagenolytic proteinases are all indicative of their latent cariogenic potential...
May 17, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28508242/preclinical-study-of-a-cost-effective-photodynamic-therapy-protocol-for-treating-oral-candidoses
#6
Nathalia Ramos da Silva, Daniela Garcia Ribeiro, João Paulo Mardegan Issa, Karla Bonfá, Michelli Sobreiro Menezes, Viviane de Cássia Oliveira, Raphael Freitas de Souza
Photodynamic therapy (PDT) is a promising treatment for oral candidoses. Its use as an alternative to antifungals prevents several adverse effects, including microbial resistance. However, most PDT protocols do not employ devices and consumables commonly available in dental practice, thus influencing treatment affordability. This study aimed to determine the efficacy of a PDT method based on light curing units' blue LEDs combined to a plaque-disclosing composition (5% erythrosine) against C. albicans in culture and in a murine model of oral candidosis...
May 15, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28500388/aspergillus-atacamensis-and-a-salisburgensis-two-new-halophilic-species-from-hypersaline-arid-habitats-with-a-phialosimplex-like-morphology
#7
Livia Martinelli, Polona Zalar, Nina Gunde-Cimerman, Armando Azua-Bustos, Katja Sterflinger, Guadalupe Piñar
Halophilic fungal strains isolated from historical wooden staircase in a salt mine in Austria, and from wall biofilm and soil of a cave in the Coastal Range of the hyperarid Atacama Desert in Chile were characterised and described newly as Aspergillus salisburgensis and Aspergillus atacamensis. Morphological characters including solitary phialides producing solitary conidia and conidia in chains and/or heads suggested affinity to Aspergillus subgenus Polypaecilum. Strains required salt for growth, grew optimally on media with 10-25% NaCl and at 15-28 °C...
May 12, 2017: Extremophiles: Life Under Extreme Conditions
https://www.readbyqxmd.com/read/28498986/sequence-of-inoculation-influences-the-nature-of-exopolymeric-substances-eps-and-biofilm-formation-in-azotobacter-chroococcum-and-trichoderma-viride
#8
Kulandaivelu Velmourougane, Radha Prasanna, Shashi Bala Singh, Rajesh Kumar, Supradip Saha
Extracellular polymeric substances (EPS) are important structural components of biofilms. In the present study, the EPS in biofilms developed using two agriculturally beneficial organisms- Azotobacter chroococcum (Az) and Trichoderma viride (Tv) were quantified and characterised. Time course experiments were undertaken to optimize the EPS yield of biofilm samples resulting from coculture and staggered inoculation. The EPS produced during biofilm formation was found to differ quantitatively and qualitatively in individual cultures (Az alone, Tv alone), and in treatments differing in the sequence of inoculation of bacterium and fungus (Az+Tv coculture, staggered inoculation of Az followed by Tv-Az-Tv, or Tv followed by Az-Tv-Az)...
May 11, 2017: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/28482568/enhanced-antifungal-activity-by-disinfected-titanium-dioxide-nanotubes-via-reduced-nano-adhesion-bonds
#9
Ernesto Beltrán-Partida, Benjamín Valdez-Salas, Mario Curiel-Álvarez, Sandra Castillo-Uribe, Alan Escamilla, Nicola Nedev
We have provided evidence that the beneficial effect of super-oxidized water (SOW) disinfected Ti6Al4V-TiO2 nanotubes (NTs) can reduce bacterial adhesion and biofilm formation. However, the need of antifungal nanostructured surfaces with osteoactive capabilities is an important goal that has been arising for dental implants (DI) applications. Thus, in the present study we isolated and tested the effects of Candida albicans (C. albicans) on disinfected, wetter and nanoroughness NTs compared to a non-modified control...
July 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28481721/s-oralis-activates-the-efg1-filamentation-pathway-in-c-albicans-to-promote-cross-kingdom-interactions-and-mucosal-biofilms
#10
Hongbin Xu, Takanori Sobue, Martinna Bertolini, Angela Thompson, Margaret Vickerman, Clarissa J Nobile, Anna Dongari-Bagtzoglou
Candida albicans and Streptococcus oralis are ubiquitous oral commensal organisms. Under host-permissive conditions these organisms can form hypervirulent mucosal biofilms. C. albicans biofilm formation is controlled by six master transcriptional regulators: Bcr1, Brg1, Efg1, Tec1, Ndt80, and Rob1. The objective of this work was to test whether any of these regulators play a role in cross-kingdom interactions between C. albicans and S. oralis in oral mucosal biofilms, and identify downstream target gene(s) that promote these interactions...
May 8, 2017: Virulence
https://www.readbyqxmd.com/read/28468513/biofouling-of-reverse-osmosis-membranes-effects-of-cleaning-on-biofilm-microbial-communities-membrane-performance-and-adherence-of-extracellular-polymeric-substances
#11
Ashraf Al Ashhab, Amer Sweity, Bihter Bayramoglu, Moshe Herzberg, Osnat Gillor
Laboratory-scale reverse osmosis (RO) flat-sheet systems were used with two parallel flow cells, one treated with cleaning agents and a control (ie undisturbed). The cleaning efforts increased the affinity of extracellular polymeric substances (EPS) to the RO membrane and altered the biofilm surface structure. Analysis of the membrane biofilm community composition revealed the dominance of Proteobacteria. However, within the phylum Proteobacteria, γ-Proteobacteria dominated the cleaned membrane biofilm, while β-Proteobacteria dominated the control biofilm...
May 4, 2017: Biofouling
https://www.readbyqxmd.com/read/28466090/microbiomes-of-biofilms-on-decorative-siliceous-stone-drawbacks-and-advantages-of-next-generation-sequencing
#12
Akiko Ogawa, Sukriye Celikkol-Aydin, Christine Gaylarde, Jose Antônio Baptista-Neto, Iwona Beech
Next Generation Sequencing (NGS), using the Illumina(®) metabarcoding system, showed differences between biofilm communities on three degraded siliceous stone church façades in central Rio de Janeiro. Two church biofilms (on granite and augen gneiss) were dominated by Actinobacteria; the third (granite), surrounded by trees and further from intense vehicular traffic, by Gammaproteobacteria. Yeast-like forms of Basidiomycetes and Ascomycetes were major fungi on all facades, but 22.8% of Operational Taxonomic Units could not be assigned to any fungal taxon after DNA amplification with ITS primers and analysis with the UNITE database, indicating the need for more fungal NGS studies...
May 2, 2017: Current Microbiology
https://www.readbyqxmd.com/read/28457835/in-vitro-activity-of-a-novel-compound-mul-1867-against-clinically-significant-fungi-candida-spp-and-aspergillus-spp
#13
George Tetz, Michael Cynamon, Gregory Hendricks, Daria Vikina, Victor Tetz
There is an urgent need for new antifungal compounds to treat various types of fungal infections, including pulmonary infections. This study was designed to investigate the potency of a novel compound (Mul-1867) against Candida spp. and Aspergillus spp. isolated from patients with fungal pneumonia, cystic fibrosis and chronic obstructive pulmonary disease. Mul-1867 was highly effective against susceptible control strains as well as resistant clinical isolates, with minimum fungicidal concentrations (MFCs) varying from 0...
April 27, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28455720/effect-of-different-fermentation-strategies-on-%C3%AE-mannanase-production-in-fed-batch-bioreactor-system
#14
Mustafa Germec, Ercan Yatmaz, Ercan Karahalil, İrfan Turhan
Mannanases, one of the important enzyme group for industry, are produced by numerous filamentous fungi, especially Aspergillus species with different fermentation methods. The aim of this study was to show the best fermentation method of β-mannanase production for fungal growth in fermenter. Therefore, different fermentation strategies in fed-batch fermentation (suspended, immobilized cell, biofilm and microparticle-enhanced bioreactor) were applied for β-mannanase production from glucose medium (GM) and carob extract medium (CEM) by using recombinant Aspergillus sojae...
May 2017: 3 Biotech
https://www.readbyqxmd.com/read/28452021/biodegradation-of-thermally-treated-low-density-polyethylene-by-fungus-rhizopus-oryzae-ns-5
#15
Shraddha Awasthi, Neha Srivastava, Tripti Singh, D Tiwary, Pradeep Kumar Mishra
Polythene is considered as one of the important object used in daily life. Being versatile in nature and resistant to microbial attack, they effectively cause environmental pollution. In the present study, biodegradation of low-density polyethylene (LDPE) have been performed using fungal lab isolate Rhizopus oryzae NS5. Lab isolate fungal strain capable of adhering to LDPE surface was used for the biodegradation of LDPE. This strain was identified as Rhizopus oryzae NS5 (Accession No. KT160362). Fungal growth was observed on the surface of the polyethylene when cultured in potato dextrose broth at 30 °C and 120 rpm, for 1 month...
May 2017: 3 Biotech
https://www.readbyqxmd.com/read/28450858/fungal-biofilms-targets-for-the-development-of-novel-strategies-in-plant-disease-management
#16
Federica Villa, Francesca Cappitelli, Paolo Cortesi, Andrea Kunova
The global food supply has been facing increasing challenges during the first decades of the 21(st) century. Disease in plants is an important constraint to worldwide crop production, accounting for 20-40% of its annual harvest loss. Although the use of resistant varieties, good water management and agronomic practices are valid management tools in counteracting plant diseases, there are still many pathosystems where fungicides are widely used for disease management. However, restrictive regulations and increasing concern regarding the risk to human health and the environment, along with the incidence of fungicide resistance, have discouraged their use and have prompted for a search for new efficient, ecologically friendly and sustainable disease management strategies...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28439794/the-effectiveness-of-voriconazole-in-therapy-of-candida-glabrata-s-biofilms-oral-infections-and-its-influence-on-the-matrix-composition-and-gene-expression
#17
Célia F Rodrigues, Bruna Gonçalves, Maria Elisa Rodrigues, Sónia Silva, Joana Azeredo, Mariana Henriques
Candida glabrata is one of most prevalent yeast in fungal infections, especially in immunocompromised patients. Its azole resistance results in a low therapeutic response, particularly when associated with biofilms. The main goal of this work was to study the effectiveness of voriconazole (Vcz) against C. glabrata biofilms oral pathologies, as esophageal or oropharyngeal candidiasis. Antifungal susceptibilities were determined in pre-formed 24-h-biofilms and ERG genes expression was determined by qRT-PCR. Protein quantification was performed using BCA(®) Kit, carbohydrate was estimated according to the Dubois assay and β-1,3 glucans concentration were determined using Glucatell(®) kit...
April 24, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28417524/biofilms-of-candida-spp-from-the-ocular-conjunctiva-of-horses-with-reduced-azole-susceptibility-a-complicating-factor-for-the-treatment-of-keratomycosis
#18
Raimunda Sâmia Nogueira Brilhante, Paula Vago Bittencourt, Débora de Souza Collares Castelo-Branco, Glaucia Morgana de Melo Guedes, Jonathas Sales de Oliveira, Lucas Pereira Alencar, Rossana de Aguiar Cordeiro, Mariana Pinheiro, Evilázio Fernandes Nogueira-Filho, Waldemiro de Aquino Pereira-Neto, José Júlio Costa Sidrim, Marcos Fábio Gadelha Rocha
OBJECTIVES: This study aimed to assess the biofilm-forming ability of Candida spp. from the ocular conjunctiva of horses and to investigate the antifungal susceptibility of these biofilms. PROCEDURES: Initially, the biofilm-forming ability of 15 strains was assessed by crystal violet staining, which reveals the fungal biomass adhered to the polystyrene plates, and scanning electron microscopy. Then, the minimum inhibitory concentrations (MICs) of amphotericin B, fluconazole, itraconazole, and caspofungin were initially determined against strains in planktonic form...
April 18, 2017: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/28411060/in%C3%A2-vitro-anti-candida-activity-of-selective-serotonin-reuptake-inhibitors-against-fluconazole-resistant-strains-and-their-activity-against-biofilm-forming-isolates
#19
Rose Anny Costa Silva, Cecília Rocha da Silva, João Batista de Andrade Neto, Anderson Ramos da Silva, Rosana Sousa Campos, Letícia Serpa Sampaio, Francisca Bruna Stefany Aires do Nascimento, Brenda da Silva Gaspar, Said Gonçalves da Cruz Fonseca, Maria Aparecida Alexandre Josino, Thalles Barbosa Grangeiro, Danielle Macedo Gaspar, David Freitas de Lucena, Manoel Odorico de Moraes, Bruno Coêlho Cavalcanti, Hélio Vitoriano Nobre Júnior
Recent research has shown broad antifungal activity of the classic antidepressants selective serotonin reuptake inhibitors (SSRIs). This fact, combined with the increased cross-resistance frequency of the genre Candida regarding the main treatment today, fluconazole, requires the development of novel therapeutic strategies. In that context, this study aimed to assess the antifungal potential of fluoxetine, sertraline, and paroxetine against fluconazole-resistant Candida spp. planktonic cells, as well as to assess the mechanism of action and the viability of biofilms treated with fluoxetine...
April 12, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28407275/agriculturally-important-microbial-biofilms-present-status-and-future-prospects
#20
REVIEW
Kulandaivelu Velmourougane, Radha Prasanna, Anil Kumar Saxena
Microbial biofilms are a fascinating subject, due to their significant roles in the environment, industry, and health. Advances in biochemical and molecular techniques have helped in enhancing our understanding of biofilm structure and development. In the past, research on biofilms primarily focussed on health and industrial sectors; however, lately, biofilms in agriculture are gaining attention due to their immense potential in crop production, protection, and improvement. Biofilms play an important role in colonization of surfaces - soil, roots, or shoots of plants and enable proliferation in the desired niche, besides enhancing soil fertility...
April 13, 2017: Journal of Basic Microbiology
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