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https://www.readbyqxmd.com/read/29330691/bis-guanylhydrazones-as-efficient-anti-candida-compounds-through-dna-interaction
#1
Jelena Lazić, Vladimir Ajdačić, Sandra Vojnovic, Mario Zlatović, Marina Pekmezovic, Selene Mogavero, Igor Opsenica, Jasmina Nikodinovic-Runic
Candida spp. are leading causes of opportunistic mycoses, including life-threatening hospital-borne infections, and novel antifungals, preferably aiming targets that have not been used before, are constantly needed. Hydrazone- and guanidine-containing molecules have shown a wide range of biological activities, including recently described excellent antifungal properties. In this study, four bis-guanylhydrazone derivatives (BG1-4) were generated following a previously developed synthetic route. Anti-Candida (two C...
January 12, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29330184/microbiomes-in-dishwashers-analysis-of-the-microbial-diversity-and-putative-opportunistic-pathogens-in-dishwasher-biofilm-communities
#2
Prem Krishnan Raghupathi, Jerneja Zupančič, Asker Daniel Brejnrod, Samuel Jacquiod, Kurt Houf, Mette Burmølle, Nina Gunde-Cimerman, Søren J Sørensen
Extreme habitats are not only limited to natural environments, but also apply to man-made systems, for instance household appliances such as dishwashers. Limiting factors, such as high temperatures, high and low pH, high NaCl concentrations, presence of detergents and shear force from water during washing cycles define the microbial survival in this extreme system. Fungal and bacterial diversity in biofilms isolated from rubber seals of 24 different household dishwashers were investigated using next generation sequencing...
January 12, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29325916/proanthocyanidin-polymeric-tannins-from-stryphnodendron-adstringens-are-effective-against-fluconazole-resistant-candida-spp-and-treat-vaginal-candidiasis
#3
Aline Luiza Duarte de Freitas, Vanessa Kaplum, Diego Conrado Pereira Rossi, Leandro Buffoni Roque da Silva, Márcia de Souza Carvalho Melhem, Carlos Pelleschi Taborda, João Carlos Palazzo de Mello, Celso Vataru Nakamura, Kelly Ishida
ETHNOPHARMACOLOGICAL RELEVANCE: The stem bark of Stryphnodendron adstringens (Mart.) Coville is popularly used as anti-inflammatory, astringent and in the treatment of wounds and vaginal infections. Several pharmacological activities have been scientifically proven by "in vitro" and "in vivo" experimental assays for antibacterial, antiviral, antiprotozoan, anti-inflammatory and antioxidant. AIM OF THE STUDY: We investigated whether proanthocyanidin polymeric tannins from the Stryphnodendron adstringens steam bark with antifungal activity against Candida albicans in vitro are also active against planktonic and biofilm cells of Candida non-albicans (CNA, including fluconazole-resistant isolates) and are capable of controlling Candida vaginitis in vivo...
January 8, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29324336/new-1-5-and-2-5-disubstituted-tetrazoles-dependent-activity-towards-surface-barrier-of-candida-albicans
#4
Monika Staniszewska, Małgorzata Gizińska, Ewa Mikulak, Klaudia Adamus, Mirosława Koronkiewicz, Edyta Łukowska-Chojnacka
A series of novel tetrazole derivatives was synthetized using N-alkylation or Michael-type addition reactions, and screened for their fungistatic potential against Candida albicans (the lack of endpoint = 100%). Among them, the selected compounds 2d, 4b, and 6a differing in substituents at the tetrazole ring were non-toxic to Galleria mellonella larvae in vivo and exerted slight toxicity against Caco-2 in vitro (CC50 at 256 μg/mL). An antagonistic effect of tetrazole derivatives 2d, 4b, and 6a respectively in combination with Fluconazole was shown using the checker board and colorimetric methods (fractional inhibitory concentration indexes FICIs >1)...
December 30, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29321629/chiloscyphenol-a-derived-from-chinese-liverworts-exerts-fungicidal-action-by-eliciting-both-mitochondrial-dysfunction-and-plasma-membrane-destruction
#5
Sha Zheng, Wenqiang Chang, Ming Zhang, Hongzhuo Shi, Hongxiang Lou
This study aimed to characterize the antifungal effects of chiloscyphenol A (CA), a natural small molecule isolated from Chinese liverworts, and investigate its mode of action. CA was effective against five tested Candida species with a minimal inhibitory concentration (MIC) of 8-32 μg/ml and exhibited fungicidal activity against Candida albicans in both the planktonic state and mature biofilms. The in vivo study using Caenorhabditis elegans showed that CA prolonged the survival of C. albicans infected worms...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29318385/transcription-factor-network-efficiency-in-the-regulation-of-candida-albicans-biofilms-it-is-a-small-world
#6
Virginia E Glazier, Damian J Krysan
Complex biological processes are frequently regulated through networks comprised of multiple signaling pathways, transcription factors, and effector molecules. The identity of specific genes carrying out these functions is usually determined by single mutant genetic analysis. However, to understand how the individual genes/gene products function, it is necessary to determine how they interact with other components of the larger network; one approach to this is to use genetic interaction analysis. The human fungal pathogen Candida albicans regulates biofilm formation through an interconnected set of transcription factor hubs and is, therefore, an example of this type of complex network...
January 9, 2018: Current Genetics
https://www.readbyqxmd.com/read/29316615/what-could-be-the-role-of-antifungal-lock-solutions-from-bench-to-bedside
#7
REVIEW
Christine Imbert, Blandine Rammaert
Candidemia related to the presence of a biofilm are often reported in patients with vascular catheters. Once they are mature, biofilms are persistent infectious reservoirs, and the yeasts dispersed from biofilms can cause infections. Sessile yeasts typically display increased levels of resistance to most antimicrobial agents and systemic treatments usually fail to eradicate previously formed fungal biofilms. In a curative strategy, antifungal lock therapy may help to sterilize catheters, with very high concentrations of antifungal agents, which are not compatible with systemic use...
January 6, 2018: Pathogens
https://www.readbyqxmd.com/read/29315476/consolidated-bioprocessing-of-lignocellulosic-biomass-to-lactic-acid-by-a-synthetic-fungal-bacterial-consortium
#8
Robert Lawrence Shahab, Jeremy S Luterbacher, Simone Brethauer, Michael Hans-Peter Studer
Consolidated bioprocessing (CBP) of lignocellulosic feedstocks to platform chemicals requires complex metabolic processes, which are commonly executed by single genetically engineered microorganisms. Alternatively, synthetic consortia can be employed to compartmentalize the required metabolic functions among different specialized microorganisms as demonstrated in this work for the direct production of lactic acid from lignocellulosic biomass. We composed an artificial cross-kingdom consortium and co-cultivated the aerobic fungus Trichoderma reesei for the secretion of cellulolytic enzymes with facultative anaerobic lactic acid bacteria...
January 8, 2018: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/29314782/chemotherapy-induced-oral-mucositis-and-associated-infections-in-a-novel-organotypic-model
#9
Takanori Sobue, Martinna Bertolini, Angela Thompson, Douglas E Peterson, Patricia I Diaz, Anna Dongari-Bagtzoglou
Oral mucositis is a common side effect of cancer chemotherapy, with significant adverse impact on the delivery of anti-neoplastic treatment. There is lack of consensus regarding the role of oral commensal microorganisms in the initiation or progression of mucositis since relevant experimental models are non-existent. The goal of this study was to develop an in vitro mucosal injury model that mimics chemotherapy-induced mucositis, where the effect of oral commensals can be studied. A novel organotypic model of chemotherapy-induced mucositis was developed based on a human oral epithelial cell line and a fibroblast-embedded collagen matrix...
January 4, 2018: Molecular Oral Microbiology
https://www.readbyqxmd.com/read/29286435/visualization-of-biofilm-formation-in-candida-albicans-using-an-automated-microfluidic-device
#10
Megha Gulati, Craig L Ennis, Diana L Rodriguez, Clarissa J Nobile
Candida albicans is the most common fungal pathogen of humans, causing about 15% of hospital-acquired sepsis cases. A major virulence attribute of C. albicans is its ability to form biofilms, structured communities of cells attached to biotic and abiotic surfaces. C. albicans biofilms can form on host tissues, such as mucosal layers, and on medical devices, such as catheters, pacemakers, dentures, and joint prostheses. Biofilms pose significant clinical challenges because they are highly resistant to physical and chemical perturbations, and can act as reservoirs to seed disseminated infections...
December 14, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29286184/in-vitro-biofilm-growth-on-modern-voice-prostheses
#11
Matthias Leonhard, Beata Zatorska, Yulong Tan, Doris Moser, Berit Schneider-Stickler
BACKGROUND: Biofilm formation on voice prostheses in laryngectomized patients usually limits the lifetime of the device. The purpose of this study was to compare the biofilm resistance of different valve flaps of modern voice prostheses in an in vitro simulation of an oropharyngeal biofilm. METHODS: Growth of biofilm deposits on valve flaps (n = 12) removed from Provox 2, Provox Vega, Provox ActiValve, Blom Singer Advantage, and Phonax voice prostheses was evaluated and compared to medical-grade silicone (n = 12) in an in vitro biofilm model (22 days) after incubation with a multispecies bacterial-fungal biofilm composition...
December 29, 2017: Head & Neck
https://www.readbyqxmd.com/read/29280555/rhizosphere-associated-alcaligenes-and-bacillus-strains-that-induce-resistance-against-blast-and-sheath-blight-diseases-enhance-plant-growth-and-improve-mineral-content-in-rice
#12
Kaleem U Kakar, Zarqa Nawaz, Zhouqi Cui, Abdulwareth A Almoneafy, Raqeeb Ullah, Qing-Yao Shu
AIMS: To examine the biocontrol activities of five rhizobacterial strains (i.e., Alcaligenes faecalis strains Bk1 and P1, Bacillus amyloliquefaciens strain Bk7, and Brevibacillus laterosporus stains B4 and S5), control the rice blast and sheath blight diseases in greenhouse, and to study their possible modes of action. METHODS AND RESULTS: Five potential plant growth promoting rhizobacterial (PGPR) strains isolated from rice rhizospheres, were tested for in vitro antifungal activities against Magnaporthe oryzae, Rhizoctonia solanii, Botrytis cinerea and Fusarium graminearum...
December 27, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29275441/corrosive-extracellular-polysaccharides-of-the-rock-inhabiting-model-fungus-knufia-petricola
#13
Romy Breitenbach, Dorothee Silbernagl, Jörg Toepel, Heinz Sturm, William J Broughton, Guilherme L Sassaki, Anna A Gorbushina
Melanised cell walls and extracellular polymeric matrices protect rock-inhabiting microcolonial fungi from hostile environmental conditions. How extracellular polymeric substances (EPS) perform this protective role was investigated by following development of the model microcolonial black fungus Knufia petricola A95 grown as a sub-aerial biofilm. Extracellular substances were extracted with NaOH/formaldehyde and the structures of two excreted polymers studied by methylation as well as NMR analyses. The main polysaccharide (~ 80%) was pullulan, also known as α-1,4-; α-1,6-glucan, with different degrees of polymerisation...
December 23, 2017: Extremophiles: Life Under Extreme Conditions
https://www.readbyqxmd.com/read/29235267/nitrate-esters-of-heteroaromatic-compounds-as-novel-candida-albicans-cyp51-enzyme-inhibitors
#14
Marija Smiljkovic, Minos-Timotheos Matsoukas, Eftichia Kritsi, Urska Zelenko, Simona Golic Grdodolnik, Ricardo Calhelha, Isabel Ferreira, Snezana Sankovic-Babic, Jasmina Glamoclija, Theano Fotopoulou, Maria Koufaki, Panagiotis Zoumpoulakis, Marina Sokovic
Four heteroaromatic compounds bearing nitrate esters were selected using a virtual screening procedure as putative sterol 14α-demethylase (CYP51) Candida albicans inhibitors. Compounds were examined for their inhibition on C. albicans growth and biofilm formation as well as for their toxicity. NMR studies, in silico docking and molecular dynamics simulations were used to further investigate selectivity of compounds to fungal CYP51. All compounds exhibited good antimicrobial properties, indicated with low minimal inhibitory concentrations and ability to inhibit formation of fungal biofilm...
December 13, 2017: ChemMedChem
https://www.readbyqxmd.com/read/29233457/antimicrobial-efficacy-of-a-novel-povidone-iodine-contact-lens-disinfection-system
#15
Katsuhide Yamasaki, Fumio Saito, Ritsue Ota, Simon Kilvington
PURPOSE: Contact lens (CL) wear is a risk factor for the acquisition of microbial keratitis. Accordingly, compliance to manufacturers' recommended hygiene and disinfection procedures are vital to safe (CL) use. In this study we evaluated a novel povidone-iodine (PI) (CL) disinfection system (cleadew, Ophtecs Corporation, Japan) against a range of bacterial, fungal and Acanthamoeba. METHODS: Antimicrobial assays were conducted according to ISO 14729 using the recommended strains of bacteria and fungi, with and without the presence of organic soil...
December 7, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/29229641/hyperbaric-oxygen-reduces-aspergillus-fumigatus-proliferation-in-vitro-and-influences-in-vivo-disease-outcomes
#16
Sourabh Dhingra, Jay C Buckey, Robert A Cramer
Recent estimates suggest that more than 3 million people have chronic or invasive fungal infections, causing more than 600,000 deaths every year. Aspergillus fumigatus causes invasive pulmonary aspergillosis (IPA) in patients with compromised immune systems and is a primary contributor to increases in human fungal infections. Thus, developing new clinical modalities as standalone or adjunctive therapy for improving IPA patient outcomes is critically needed. Here we test the in vitro and in vivo impact of hyperbaric oxygen (100% oxygen, >1 ATA) (HBO) on A...
December 11, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29228383/oral-fungal-bacterial-biofilm-models-in-vitro-a-review
#17
Marlene Chevalier, Stephane Ranque, Isabelle Prêcheur
Inclusion of fungi as commensals in oral biofilm is an important innovation in oral biology, and this work aimed to review the literature on the available biofilm and related disease in vitro models. Actually, thousands of bacterial and around one hundred of fungal phylotypes can colonize the oral cavity. Taxonomic profiling combined with functional expression analysis has revealed that Candida albicans, Streptococcus mutans and prominent periodontopathogens are not always present or numerically important in candidiasis, caries, or periodontitis lesions...
December 8, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/29227087/new-application-of-neomycin-b-bisbenzimidazole-hybrids-as-antifungal-agents
#18
Nishad Thamban Chandrika, Sanjib K Shrestha, Nihar Ranjan, Anindra Sharma, Dev P Arya, Sylvie Garneau-Tsodikova
Alkylated aminoglycosides and bisbenzimidazoles have previously been shown to individually display antifungal activity. Herein, we explore for the first time the antifungal activity (in liquid cultures and in biofilms) of ten alkylated aminoglycosides covalently linked to either mono- or bisbenzimidazoles. We also investigate their toxicity against mammalian cells, their hemolytic activity, and their potential mechanism(s) of action (inhibition of fungal ergosterol biosynthetic pathway and/or reactive oxygen species (ROS) production)...
December 11, 2017: ACS Infectious Diseases
https://www.readbyqxmd.com/read/29223551/recent-advances-in-delivery-of-antifungal-agents-for-therapeutic-management-of-candidiasis
#19
REVIEW
Bhakti Sawant, Tabassum Khan
Candidiasis is a fungal infection caused by yeasts that belong to the genus Candida. There are over twenty species of Candida yeasts that can cause infection in humans, the most common of which is Candida albicans. Candida yeasts normally reside in the intestinal tract and can be found on mucous membranes and skin without causing infection; however, overgrowth of these organisms can cause symptoms to develop. Presence of other diseases that compromises the patient's immunity makes it more difficult to treat...
December 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29211748/interactions-between-abundant-fungal-species-influence-the-fungal-community-assemblage-on-limestone
#20
Alejandro Morón-Ríos, Sergio Gómez-Cornelio, Benjamin Otto Ortega-Morales, Susana De la Rosa-García, Laila Pamela Partida-Martínez, Patricia Quintana, José Armando Alayón-Gamboa, Silvia Cappello-García, Santiago González-Gómez
The assembly of fungal communities on stone materials is mainly influenced by the differential bioreceptivity of such materials and environmental conditions. However, little is known about the role of fungal interactions in the colonization and establishment of fungal species. We analyzed the effects of intra- and interspecific interactions between 11 species of fungi in oligotrophic and copiotrophic media and on limestone coupons. In a previous study, these species were the most frequently isolated in the epilithic biofilms of limestone walls exposed to a subtropical climate...
2017: PloS One
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