keyword
https://read.qxmd.com/read/38537031/anti-biofilm-effectiveness-of-protocols-for-cleaning-complete-dentures-in-hospitalized-patients-a-randomized-controlled-trial
#1
JOURNAL ARTICLE
Anna Clara Gurgel Gomes, Janaina Gomes Maciel, Amanda Aparecida Maia Neves Garcia, Letycia Accioly Simões Coelho, Giulia Murcia Rodrigues, Vinicius Carvalho Porto, Grigorios Polyzois, Marlise Inêz Klein, Simone Soares, Vanessa Migliorini Urban, Karin Hermana Neppelenbroek
BACKGROUND: Denture biofilm acts as a potential reservoir for respiratory pathogens, considerably increasing the risk of lung infections, specifically aspiration pneumonia, mainly 48h after hospital admission. The establishment of a straightforward, affordable, and applicable hygiene protocol in a hospital environment for the effective control of denture biofilm can be particularly useful to prevent respiratory infections or reduce the course of established lung disease. OBJECTIVES: To evaluate the anti-biofilm effectiveness of denture cleaning protocols in hospitalized patients...
2024: Journal of Applied Oral Science: Revista FOB
https://read.qxmd.com/read/38535230/hsp90-mediated-multi-drug-resistance-in-dna-polymerase-defective-strains-of-candida-albicans
#2
JOURNAL ARTICLE
Bhabasha Gyanadeep Utkalaja, Satya Ranjan Sahu, Sushree Subhashree Parida, Narottam Acharya
The incidence of infections caused by Candida species, specifically by drug-resistant isolates, is a major health concern as they can disseminate to and colonize most vital organs, enhancing morbidity and mortality. Several molecular mechanisms have been reported to be involved in drug resistance. These are mostly drug- and isolate-specific. Here, we characterized three different genetically modified strains of C. albicans that were multi-drug-resistant (MDR) and deciphered a uniform mechanism responsible for resistance...
March 19, 2024: Journal of Fungi (Basel, Switzerland)
https://read.qxmd.com/read/38534657/a-cyclam-salt-as-an-antifungal-agent-interference-with-candida-spp-and-cryptococcus-neoformans-mechanisms-of-virulence
#3
JOURNAL ARTICLE
Fátima Cerqueira, Rui Medeiros, Inês Lopes, Carla Campos, Maria Pia Ferraz, Fernando Silva, Luís G Alves, Eugénia Pinto
The importance of fungal infections, particularly those caused by yeasts, is increasing among the medical community. Candida albicans and Cryptococcus neoformans are amongst the high-priority fungal species identified by the World Health Organization (WHO) and are considered in the critical group, while Candida krusei is included in the medium-priority group. The cyclam salt H4 [H2 (4-CF3 PhCH2 )2 Cyclam]Cl4 proved to be active against the growth of these three yeasts, and the aim of this work was to verify its interference with their virulence mechanisms, whether shared or unique...
February 28, 2024: Antibiotics
https://read.qxmd.com/read/38534121/analyzing-the-safety-of-the-parasiticide-fungus-mucor-circinelloides-first-insights-on-its-virulence-profile-and-interactions-with-the-avian-gut-microbial-community
#4
JOURNAL ARTICLE
João Lozano, Eva Cunha, Cristina Almeida, Mónica Nunes, Ricardo Dias, Eduardo Vicente, Daniela Sebastião, Sérgio Henriques, Luís Madeira de Carvalho, Adolfo Paz-Silva, Manuela Oliveira
Parasiticide fungi are considered an accurate, sustainable, and safe solution for the biocontrol of animal gastrointestinal (GI) parasites. This research provides an initial characterization of the virulence of the native parasiticide fungus Mucor circinelloides (FMV-FR1) and an assessment of its impact on birds' gut microbes. The genome of this fungus was sequenced to identify the genes coding for virulence factors. Also, this fungus was checked for the phenotypic expression of proteinase, lecithinase, DNase, gelatinase, hemolysin, and biofilm production...
March 27, 2024: Microbiology Spectrum
https://read.qxmd.com/read/38525143/biofilm-containing-the-thymus-serpyllum-essential-oil-for-rice-and-cherry-tomato-conservation
#5
JOURNAL ARTICLE
Josefa Roselló, Juan Antonio Llorens-Molina, Silvina Larran, Francisca Sempere-Ferre, M Pilar Santamarina
INTRODUCTION: Fungal pathogens cause major yield losses in agriculture and reduce food quality and production worldwide. PURPOSE: To evaluate new safer alternatives to chemicals for disease management and preserve the shelf life of food, this research was conducted to: determine the chemical composition of the essential oils (EOs) of Thymus serpyllum and Thymus piperella chemotypes 1 and 2; investigate the antifungal potential of EOs in vitro against: Alternaria alternata , Bipolaris spicifera , Curvularia hawaiiensis , Fusarium oxysporum f...
2024: Frontiers in Plant Science
https://read.qxmd.com/read/38509138/oxygen-dependent-biofilm-dynamics-in-leaf-decay-an-in-vitro-analysis
#6
JOURNAL ARTICLE
Sabina Karačić, Brianne Palmer, Carole T Gee, Gabriele Bierbaum
Biofilms are important in the natural process of plant tissue degradation. However, fundamental knowledge of biofilm community structure and succession on decaying leaves under different oxygen conditions is limited. Here, we used 16S rRNA and ITS gene amplicon sequencing to investigate the composition, temporal dynamics, and community assembly processes of bacterial and fungal biofilms on decaying leaves in vitro. Leaves harvested from three plant species were immersed in lake water under aerobic and anaerobic conditions in vitro for three weeks...
March 20, 2024: Scientific Reports
https://read.qxmd.com/read/38507998/synthesis-structure-activity-relationship-and-biological-evaluation-of-indole-derivatives-as-anti-candida-albicans-agents
#7
JOURNAL ARTICLE
Yandan Wu, Aimei Sun, Fei Chen, Yin Zhao, Xianhu Zhu, Tianbao Zhang, Guanghui Ni, Ruirui Wang
In this work, we synthesized a series of indole derivatives to cope with the current increasing fungal infections caused by drug-resistant Candida albicans. All compounds were evaluated for antifungal activities against Candida albicans in vitro, and the structure-activity relationships (SARs) were analyzed. The results indicated that indole derivatives used either alone or in combination with fluconazole showed good activities against fluconazole-resistant Candida albicans. Further mechanisms studies demonstrated that compound 1 could inhibit yeast-to-hypha transition and biofilm formation of Candida albicans, increase the activity of the efflux pump, the damage of mitochondrial function, and the decrease of intracellular ATP content...
March 16, 2024: Bioorganic Chemistry
https://read.qxmd.com/read/38507790/co-immobilization-of-ciprofloxacin-and-chlorhexidine-as-a-broad-spectrum-antimicrobial-dual-drug-coating-for-poly-vinyl-chloride-pvc-based-endotracheal-tubes
#8
JOURNAL ARTICLE
Diana Filipa Alves, Maria Olívia Pereira, Susana Patrícia Lopes
The endotracheal tube (ETT) affords support for intubated patients, but the increasing incidence of ventilator-associated pneumonia (VAP) is jeopardizing its application. ETT surfaces promote (poly)microbial colonization and biofilm formation, with a heavy burden for VAP. Devising safe, broad-spectrum antimicrobial materials to tackle the ETT bioburden is needful. Herein, we immobilized ciprofloxacin (CIP) and/or chlorhexidine (CHX), through polydopamine (pDA)-based functionalization, onto poly(vinyl chloride) (PVC) surfaces...
March 20, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38498997/oral-rinses-some-kill-and-some-cripple-candida-albicans
#9
JOURNAL ARTICLE
Homa Darmani, Dua'a Riyad Husain Al-Saleh
OBJECTIVES: Oral healthcare professionals play a crucial role in guiding patients toward evidence-based choices among the many available oral rinses. In this study, we explored how specific oral rinse formulations affect the viability and modulate critical virulence traits of the opportunistic fungal pathogen Candida albicans. MATERIALS AND METHODS: We assessed the effects of these oral rinses on the production of germ tube, production of phospholipase and hemolysin, as well as biofilm formation...
March 18, 2024: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://read.qxmd.com/read/38495880/modulation-of-myeloid-derived-suppressor-cell-functions-by-oral-inflammatory-diseases-and-important-oral-pathogens
#10
REVIEW
Fernando García-Arévalo, Ana Gabriela Leija-Montoya, Javier González-Ramírez, Mario Isiordia-Espinoza, Idanya Serafín-Higuera, Dulce Martha Fuchen-Ramos, J Gustavo Vazquez-Jimenez, Nicolas Serafín-Higuera
The oral cavity presents a diverse microbiota in a dynamic balance with the host. Disruption of the microbial community can promote dysregulation of local immune response which could generate oral diseases. Additionally, alterations in host immune system can result in inflammatory disorders. Different microorganisms have been associated with establishment and progression of the oral diseases. Oral cavity pathogens/diseases can modulate components of the inflammatory response. Myeloid-derived suppressor cells (MDSCs) own immunoregulatory functions and have been involved in different inflammatory conditions such as infectious processes, autoimmune diseases, and cancer...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38494241/unveiling-the-inverse-antimicrobial-impact-of-a-hetero-chitooligosaccharide-on-candida-tropicalis-growth-and-biofilm-formation
#11
JOURNAL ARTICLE
Yangyang Liu, Ruilian Li, Yuchen Zhang, Siming Jiao, Tong Xu, Yuhang Zhou, Yujing Wang, Jinhua Wei, Wei Du, Morihisa Fujita, Yuguang Du, Zhuo A Wang
Chitosan and chitooligosaccharide (COS) are renowned for their potent antimicrobial prowess, yet the precise antimicrobial efficacy of COS remains elusive due to scant structural information about the utilized saccharides. This study delves into the antimicrobial potential of COS, spotlighting a distinct hetero-chitooligosaccharide dubbed DACOS. In contrast to other COS, DACOS remarkably fosters the growth of Candida tropicalis planktonic cells and fungal biofilms. Employing gradient alcohol precipitation, DACOS was fractionated, unveiling diverse structural characteristics and differential impacts on C...
June 1, 2024: Carbohydrate Polymers
https://read.qxmd.com/read/38481158/analysis-of-the-complete-genome-sequence-of-paenibacillus-sp-lzh-n1-reveals-its-antagonistic-ability
#12
JOURNAL ARTICLE
Ee Li, Kaiquan Liu, Shuhan Yang, Ling Li, Kun Ran, Xiaoli Sun, Jie Qu, Li Zhao, Yuxiu Xin, Feng Zhu, Jingfang Ma, Feng Song, Zhenghua Li
BACKGROUND: Plant diseases caused by pathogenic fungi are devastating. However, commonly used fungicides are harmful to the environment, and some are becoming ineffective due to fungal resistance. Therefore, eco-friendly biological methods to control pathogenic fungi are urgently needed. RESULTS: In this study, a strain, Paenibacillus sp. lzh-N1, that could inhibit the growth of the pathogenic fungus Mycosphaerella sentina (Fr) Schrorter was isolated from the rhizosphere soil of pear trees, and the complete genome sequence of the strain was obtained, annotated, and analyzed to reveal the genetic foundation of its antagonistic ability...
March 13, 2024: BMC Genomics
https://read.qxmd.com/read/38477802/anticandida-and-antibiofilm-activities-of-extract-from-schinopsis-brasiliensis-engl-against-candida-spp
#13
JOURNAL ARTICLE
Vanessa de Carvalho Jovito, Jefferson Muniz de Lima, Marianne de Lucena Rangel, Brenna Louise Cavalcanti Gondim, Paula Lima Nogueira, Ana Claúdia Dantas de Medeiros, Marianna Vieira Sobral, Ricardo Dias de Castro, Lúcio Roberto Cançado Castellano
The pathogenic nature of infections caused by Candida spp. underscores the necessity for novel therapeutic agents. Extracts of Schinopsis brasilienses Engl are \ a promising source of agents with antifungal effects. This study aimed to assess the antifungal potential of the leaf extract of S. brasilienses. The antifungal activity was evaluated by determining the minimum inhibitory concentrations and fungicide concentrations (MIC and MFC). The antibiofilm potential was assessed by counting colony-forming units/mL...
2024: Brazilian Oral Research
https://read.qxmd.com/read/38470537/regulatory-features-of-candida-albicans-hemin-induced-filamentation
#14
JOURNAL ARTICLE
Liping Xiong, Katharina Goerlich, Aaron P Mitchell
Candida albicans is a prominent fungal pathogen that can infect the bloodstream and deep tissues. One key pathogenicity trait is the ability to transition between yeast and hyphal growth. Hyphae are critical for the formation of biofilms, which in turn enable device-associated infection. Among signals that drive hypha formation is the presence of hemin, an oxidized Fe(III)-containing heme derivative found in blood. In this study we asked four questions. First, how uniform is the filamentation response to hemin among C...
March 12, 2024: G3: Genes—Genomes—Genetics
https://read.qxmd.com/read/38467906/novel-thiazolinyl-picolinamide-based-palladium-ii-complex-extenuates-the-virulence-and-biofilms-of-vulvovaginal-candidiasis-vvc-causing-candida
#15
JOURNAL ARTICLE
Munieswaran Gayatri, Sowndarya Jothipandiyan, Mohamed Khalid Abdul Azeez, Murugesan Sudharsan, Devarajan Suresh, Paramasivam Nithyanand
Candida infections are growing all over the world as a result of their resistance to anti-fungal drugs. This raises concerns about public health, particularly in cases of vulvovaginal candidiasis (VVC). Therefore, the need for effective treatment options for Candida infections has become crucial. The main goal of the study is to evaluate the efficacy of novel palladium metal complexes against fluconazole-resistant Candida spp., particularly C. albicans and C. auris. The process begins with identifying the minimum inhibitory concentration (MIC), followed by growth curve assays, colony morphology analysis, characterization, and gene expression analysis...
March 11, 2024: International Microbiology: the Official Journal of the Spanish Society for Microbiology
https://read.qxmd.com/read/38459502/unveiling-biological-activities-of-biosynthesized-starch-silver-selenium-nanocomposite-using-cladosporium-cladosporioides-cbs-174-62
#16
JOURNAL ARTICLE
Fathy M Elkady, Amr H Hashem, Salem S Salem, Gharieb S El-Sayyad, Ahmed Abdel Tawab, Mohammad M Alkherkhisy, Mohammed S Abdulrahman
BACKGROUND AND OBJECTIVES: Microbial cells capability to tolerate the effect of various antimicrobial classes represent a major worldwide health concern. The flexible and multi-components nanocomposites have enhanced physicochemical characters with several improved properties. Thus, different biological activities of biosynthesized starch/silver-selenium nanocomposite (St/Ag-Se NC) were assessed. METHODOLOGY: The St/Ag-Se NC was biosynthesized using Cladosporium cladosporioides CBS 174...
March 8, 2024: BMC Microbiology
https://read.qxmd.com/read/38458677/investigation-of-the-antibacterial-activity-of-benziothiazolinone-against-xanthomonas-oryzae-pv-oryzae
#17
JOURNAL ARTICLE
Xing Chen, Chaoyue Pang, Xueqiao Liu, Jiazhi Sun, Ling Jin, Yang Sun, Yu Chen
Plant pathogenic bacteria can cause numerous diseases for higher plants and result in severe reduction of crop yield. Introduction of new bactericides can always effectively control these plant diseases. Benziothiazolinone (BIT) is a novel fungicide registered in China for the control of plant fungal diseases, however, its anti-bacterial activity is not well studied. The results of activity tests showed that BIT exhibited stronger inhibitory activity against bacteria, particularly for Xanthomonas oryzae pv...
February 2024: Pesticide Biochemistry and Physiology
https://read.qxmd.com/read/38453640/mechanophysical-and-anti-adhesive-properties-of-a-nanoclay-containing-pmma-denture-resin
#18
JOURNAL ARTICLE
Jun-Yong Ahn, Yu-Jin Kim, Jung-Hwan Lee, Rajendra K Singh, Hae-Hyoung Lee
Poly(methyl methacrylate) (PMMA) is commonly used for dental dentures, but it has the drawback of promoting oral health risks due to oral bacterial adhesion. Recently, various nanoparticles have been incorporated into PMMA to tackle these issues. This study aims to investigate the mechanophysical and antimicrobial adhesive properties of a denture resin by incorporating of nanoclay into PMMA. Specimens were prepared by adding 0, 1, 2, and 4 wt % surface-modified nanoclay (Sigma) to self-polymerizing PMMA denture resin...
March 7, 2024: ACS Biomaterials Science & Engineering
https://read.qxmd.com/read/38452422/a-metabolomics-footprinting-approach-using-gc-ms-to-study-inhibitory-effects-of-the-fungal-metabolite-diplopyrone-c-against-nosocomial-pathogen-biofilms
#19
JOURNAL ARTICLE
Maria Michela Salvatore, Angela Maione, Marianna Imparato, Francesco Salvatore, Marco Guida, Emilia Galdiero, Anna Andolfi
Seen initially as wonder drugs, the widespread and often inappropriate use of antibiotics led to the development of microbial resistances. As a result, a true emergency has arisen, and a significant need has emerged to discover and develop new safe and valuable antibiotics. The captivating chemical structure of the fungal metabolite diplopyrone C has caught our attention as an excellent candidate for a circumstantial study aimed at revealing its antimicrobial and antibiofilm activities. In this work, we describe the full analytical strategy from the isolation/identification to the evaluation of the metabolomics effect on target microorganisms of this fungal metabolite...
March 2, 2024: Journal of Pharmaceutical and Biomedical Analysis
https://read.qxmd.com/read/38446770/studying-mixed-species-biofilms-of-candida-albicans-and-staphylococcus-aureus-using-evolutionary-game-theory
#20
JOURNAL ARTICLE
Sybille Dühring, Stefan Schuster
Mixed-species biofilms of Candida albicans and Staphylococcus aureus pose a significant clinical challenge due to their resistance to the human immune system and antimicrobial therapy. Using evolutionary game theory and nonlinear dynamics, we analyse the complex interactions between these organisms to understand their coexistence in the human host. We determine the Nash equilibria and evolutionary stable strategies of the game between C. albicans and S. aureus and point out different states of the mixed-species biofilm...
2024: PloS One
keyword
keyword
38066
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.