Lorenzo Lazzerini-Ospri, Jesse J Zhan, Michael B Thomsen, Hui Wang, Fany Messanvi, Johann du Hoffmann, Kevin Cravedi, Ruchi Komal, Yogita Chudasama, Haiqing Zhao, Samer Hattar
UNLABELLED: The ventromedial prefrontal cortex (vmPFC) is a part of the limbic system engaged in the regulation of social, emotional and cognitive states, which are characteristically impaired in disorders of the brain such as schizophrenia and depression. Here, we show that intrinsically photosensitive retinal ganglion cells (ipRGCs) modulate, through light, the integrity, activity and function of the vmPFC. This regulatory role, which is independent of circadian and mood alterations, is mediated by an ipRGC-thalamic-corticolimbic pathway...
September 25, 2023: bioRxiv