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https://www.readbyqxmd.com/read/28927187/impact-of-co-morbid-burden-on-mortality-in-patients-with-coronary-heart-disease-heart-failure-and-cerebrovascular-accident-a-systematic-review-and-meta-analysis
#1
Muhammad Rashid, Chun Shing Kwok, Chris P Gale, Patrick Doherty, Ivan Olier, Matthew Sperrin, Evangelos Kontopantelis, George Peat, Mamas A Mamas
Aims: We sought to investigate the prognostic impact of co-morbid burden as defined by the Charlson Co-morbidity Index (CCI) in patients with a range of prevalent cardiovascular diseases. Methods and results: We searched MEDLINE and EMBASE to identify studies that evaluated the impact of CCI on mortality in patients with cardiovascular disease. A random-effects meta-analysis was undertaken to evaluate the impact of CCI on mortality in patients with coronary heart disease (CHD), heart failure (HF), and cerebrovascular accident (CVA)...
January 1, 2017: European Heart Journal. Quality of Care & Clinical Outcomes
https://www.readbyqxmd.com/read/28927176/permanent-work-disability-in-patients-%C3%A2-50-years-old-after-percutaneous-coronary-intervention-and-coronary-artery-bypass-grafting-the-crags-study
#2
Anna Lautamäki, Jarmo M Gunn, Kari Eino Juhani Airaksinen, Fausto Biancari, Olli A Kajander, Vesa Anttila, Jouni Heikkinen, Markku Eskola, Erkki Ilveskoski, Ari Mennander, Kari Korpilahti, Jan-Ola Wistbacka, Tuomas O Kiviniemi
Background: The aim of this study was to investigate the incidence of permanent working disability (PWD) in young patients after percutaneous or surgical coronary revascularization. Methods and Results: The study included 1035 consecutive patients ≤50 years old who underwent coronary revascularization [910 and 125 patients in percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) groups, respectively] between 2002 and 2012 at 4 Finnish hospitals...
April 1, 2017: European Heart Journal. Quality of Care & Clinical Outcomes
https://www.readbyqxmd.com/read/28926972/juvenile-moyamoya-and-craniosynostosis-in-a-child-with-deletion-1p32p31-expanding-the-clinical-spectrum-of-1p32p31-deletion-syndrome-and-a-review-of-the-literature
#3
Paolo Prontera, Daniela Rogaia, Amedea Mencarelli, Valentina Ottaviani, Ester Sallicandro, Giorgio Guercini, Susanna Esposito, Anna Bersano, Giuseppe Merla, Gabriela Stangoni
Moyamoya angiopathy (MA) is a rare cerebrovascular disorder characterised by the progressive occlusion of the internal carotid artery. Its aetiology is uncertain, but a genetic background seems likely, given the high MA familial rate. To investigate the aetiology of craniosynostosis and juvenile moyamoya in a 14-year-old male patient, we performed an array-comparative genomic hybridisation revealing a de novo interstitial deletion of 8.5 Mb in chromosome region 1p32p31. The deletion involved 34 protein coding genes, including NF1A, whose haploinsufficiency is indicated as being mainly responsible for the 1p32-p31 chromosome deletion syndrome phenotype (OMIM 613735)...
September 17, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28925920/low-radon-exposure-and-mortality-among-jouac-uranium-miners-an-update-of-the-french-cohort-1946-2007
#4
Estelle Rage, Sylvaine Caër-Lorho, Dominique Laurier
After the extension of the French cohort of uranium miners with the inclusion of workers employed in the Jouac mines, this article seeks to describe the new Jouac cohort and to estimate mortality risks, as well as to quantify their relation to radon exposure in this extended cohort. The Jouac cohort includes 458 miners hired by the Société des Mines de Jouac between 1957 and 2001. As there is no measurement of radon exposure before 1978 were unavailable, only the post-1977 Jouac cohort (n=314) has been included in the French cohort, creating an extended cohort of 5400 French uranium miners followed up from 1946 to 2007...
September 19, 2017: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/28925529/cerebrovascular-response-to-the-cold-pressor-test-the-critical-role-of-carbon-dioxide
#5
Michael M Tymko, Thijs P Kerstens, Kevin W Wildfong, Philip N Ainslie
In addition to increasing sympathetic nervous activity, blood pressure, and cerebral blood flow (CBF), the cold pressor test (CPT) stimulates pain receptors, which may increase ventilation above metabolic demand; this response likely reduces the partial pressure of end-tidal carbon dioxide (PET CO2 ), and will attenuate elevations in CBF. We hypothesized: (1) CPT would elicit hyperventilation, effectively lowering PET CO2 ; (2) the CBF response will be elevated during an isocapnic (controlled PET CO2 ), compared to a poikilocapnic CPT (uncontrolled PET CO2 ); (3) In response to CPT, the common carotid artery (CCA) will vasodilatate, while the internal carotid artery (ICA) will remain unchanged to help regulate CBF...
September 19, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28925030/drug-repurposing-may-generate-novel-approaches-to-treating-depression
#6
REVIEW
Mohamed Elsaed Ebada
OBJECTIVES: The breakthrough advancements in scientific medical research have greatly improved our understanding of the pathogenesis of depression, encouraging drug discoverers to take a shorter path than ever through drug repurposing to generate new antidepressant medications. In addition to reduced noradrenergic and serotonergic neurotransmission in the brain, other coincidence features such as glutamate neurotoxicity, inflammation and/or cerebrovascular insufficiency are implicated in the pathogenesis of major depressive disorder and late-life depression...
September 18, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28924565/nirs-based-cerebrovascular-regulation-assessment-exercise-and-cerebrovascular-reactivity
#7
Stephanie Miller, Kunal Mitra
Alterations to cerebral blood flow (CBF) have been implicated in diverse neurological conditions. Near-infrared spectroscopy (NIRS)-measured regional cerebral tissue oxygen saturation ([Formula: see text]) provides an estimate of oxygenation of interrogated cerebral volume useful in identifying variations in oxygen supply to cerebral tissue and in monitoring cerebrovascular function. [Formula: see text]-inhalation-based hypercapnic breathing challenges were used to simulate CBF dysregulation, utilizing NIRS to monitor the CBF autoregulatory response...
October 2017: Neurophotonics
https://www.readbyqxmd.com/read/28924073/-clinical-applications-of-positron-emission-tomography-for-neurosurgery-2-progress-of-pathophysiological-diagnosis-using-sup-15-sup-o-gas-pet-for-cerebrovascular-disease
#8
Jyoji Nakagawara
No abstract text is available yet for this article.
September 2017: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/28923761/surgical-treatment-of-obstructive-sleep-apnea-on-cardiovascular-outcomes-a-systematic-review
#9
Tyler R Halle, Melissa S Oh, Nancy A Collop, Arshed A Quyyumi, Donald L Bliwise, Raj C Dedhia
BACKGROUND: Obstructive sleep apnea (OSA) is an increasingly prevalent clinical problem with significant effects on quality of life and cardiovascular risk. Surgical therapy represents an important treatment for those unable to use positive airway pressure. This systematic review examines the available cardiovascular risk reduction data for surgical treatment of OSA. METHODS: A comprehensive literature search was performed. Articles were included if they met the following criteria: (1) adults >18 years (2) OSA diagnosed by sleep study; (3) surgical intervention performed for OSA; (4) one or more physical or biochemical cardiovascular and/or cerebrovascular variables was measured pre-operatively and at ≥14 days postoperatively...
September 15, 2017: Chest
https://www.readbyqxmd.com/read/28923026/dementia-and-cognitive-disorder-identified-at-a-forensic-psychiatric-examination-a-study-from-sweden
#10
Anette Ekström, Marianne Kristiansson, Karin Sparring Björkstén
BACKGROUND: Few studies have addressed the relationship between dementia and crime. We conducted a study of persons who got a primary or secondary diagnosis of dementia or cognitive disorder in a forensic psychiatric examination. METHODS: In Sweden, annually about 500 forensic psychiatric examinations are carried out. All cases from 2008 to 2010 with the diagnoses dementia or cognitive disorder were selected from the database of the Swedish National Board of Forensic Medicine...
September 18, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28922877/use-of-a-polytetrafluoroethylene-coated-vascular-plug-for-focal-intracranial-parent-vessel-sacrifice-for-fusiform-aneurysm-treatment
#11
Andrew P Carlson, Mohammad Abbas, Patricia Hall, Christopher Taylor
BACKGROUND: Fusiform intracranial aneurysms are challenging due to the circumferential nature of the disease. Endovascular parent vessel sacrifice with coils may be a treatment option, but typically requires a long vessel segment to induce complete cessation of flow. OBJECTIVE:   We evaluate early clinical experience with the intracranial use of the microvascular plug (MVP; Medtronic, Dublin, Ireland) device and to compare to previous coil-only techniques for vertebral artery sacrifice for fusiform vertebral aneurysm...
October 1, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28922275/indications-for-ct-angiography-of-the-vertebral-arteries-after-trauma
#12
Joseph P Drain, Douglas S Weinberg, James S Ramey, Timothy A Moore, Heather A Vallier
STUDY DESIGN: Retrospective. OBJECTIVE: The purpose of this project is to identify factors that predict vertebral artery injury (VAI) in an effort to assess risks and benefits of computed tomography angiography (CT-A) of the neck in the trauma setting. We seek to develop guidelines for practitioners to stratify patients at medium/high risk of VAI from those who are at low risk. SUMMARY OF BACKGROUND DATA: VAI and blunt carotid injury (BCI) together comprise blunt cerebrovascular injury (BCVI)...
September 15, 2017: Spine
https://www.readbyqxmd.com/read/28922154/atrial-fibrillation-is-independently-associated-with-cognitive-impairment-after-ischemic-stroke
#13
Russell Jude Chander, Levinia Lim, Sagarika Handa, Shaun Hiu, Angeline Choong, Xuling Lin, Rajinder Singh, Daniel Oh, Nagaendran Kandiah
BACKGROUND: While atrial fibrillation (AF) is an important risk factor for ischemic strokes and mild cognitive impairment (MCI) in Alzheimer's disease, the association between AF and post-stroke cognitive impairment (PSCI), and the factors mediating this association, is unclear. OBJECTIVE: To investigate the role of AF in PSCI, especially in relation to other markers of cerebrovascular disease. METHODS: 445 subjects with mild ischemic stroke without pre-stroke cognitive decline were assessed 3-6 months post-stroke for cognitive deficits...
September 7, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28921837/coronary-artery-bypass-grafting-versus-percutaneous-coronary-intervention-in-patients-with-non-insulin-treated-type-2-diabetes-mellitus-a-meta-analysis-of-randomized-controlled-trials
#14
Yushu Wang, Meiqin Wen, Junteng Zhou, Yucheng Chen, Qing Zhang
INTRODUCTION: The outcomes and prognosis of revascularization by either coronary artery bypass grafting (CABG) surgery or percutaneous coronary intervention (PCI) in patients with non-insulin treated type 2 diabetes mellitus (NITDM) have not yet been well established. METHODS: Randomized controlled trials (RCTs) were identified by searching Pubmed, EMBASE and Cochrane library from inception until May 2016. Heterogeneity was evaluated and the pooled hazard ratio (HR) was calculated using a fixed-effect model...
September 15, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28921308/pregnancy-and-delivery-in-moyamoya-vasculopathy-experience-of-a-single-european-institution
#15
Güliz Acker, Marcus Czabanka, Peter Schmiedek, Peter Vajkoczy
Moyamoya vasculopathy (MMV) is a stenoocclusive cerebrovascular disease frequently affecting adolescent females. Thus, the management of pregnancy is of major interest for physicians dealing with MMV patients. However, clinical data concerning pregnant MMV patients is lacking. Our aim was to analyze the course of pregnancy in our European MMV patient cohort. We retrospectively identified MMV patients with a history of pregnancy who were treated in our institution. We analyzed demographic data, clinical symptoms, treatment, and detailed history of pregnancies...
September 18, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/28920182/neovascularization-and-synaptic-function-regulation-with-memantine-and-rosuvastatin-in-a-rat-model-of-chronic-cerebral-hypoperfusion
#16
Nan Zhang, Chenchen Song, Baomin Zhao, Mengya Xing, Lanlan Luo, Marc L Gordon, Yan Cheng
Cerebral hypoperfusion is an important factor in the pathogenesis of cerebrovascular diseases and neurodegenerative disorders. We investigated the effects of memantine and rosuvastatin on both neovascularization and synaptic function in a rat model of chronic cerebral hypoperfusion, which was established by the bilateral common carotid occlusion (2VO) method. We tested learning and memory ability, synaptic function, circulating endothelial progenitor cell (EPC) number, expression of neurotrophic factors, and markers of neovasculogenesis and cell proliferation after memantine and/or rosuvastatin treatment...
September 17, 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/28919749/ginsenoside-rg1-nanoparticle-penetrating-the-blood-brain-barrier-to-improve-the-cerebral-function-of-diabetic-rats-complicated-with-cerebral-infarction
#17
Junyi Shen, Zhiming Zhao, Wei Shang, Chunli Liu, Beibei Zhang, Lingjie Zhao, Hui Cai
Diabetic cerebral infarction is with poorer prognosis and high rates of mortality. Ginsenoside Rg1 (Rg1) has a wide variety of therapeutic values for central nervous system (CNS) diseases for the neuron protective effects. However, the blood-brain barrier (BBB) restricts Rg1 in reaching the CNS. In this study, we investigated the therapeutic effects of Rg1 nanoparticle (PHRO, fabricated with γ-PGA, L-PAE (H), Rg1, and OX26 antibody), targeting transferrin receptor, on the diabetes rats complicated with diabetic cerebral infarction in vitro and in vivo...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28919704/secondary-prevention-of-major-cerebrovascular-events-with-seven-different-statins-a-multi-treatment-meta-analysis
#18
Ping Zhong, Danhong Wu, Xiaofei Ye, Ying Wu, Tuming Li, Shuwen Tong, Xueyuan Liu
BACKGROUND: Statins have been recommended for the use in atherosclerotic cardiovascular diseases, but different statins have distinct pharmacological characteristics. This multi-treatment meta-analysis aimed to evaluate the efficacy of seven statins in the secondary prevention of major cerebrovascular events (CVEs). METHODS AND ANALYSES: The PubMed, Embase, Cochrane Database of Systematic Reviews and Cochrane Central Register of Controlled Trials were searched to identify studies published between January 1, 2011, and June 30, 2016...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28919565/treatment-of-large-or-giant-cavernous-aneurysm-associated-with-a-persistent-trigeminal-artery-a-case-report-and-review-of-literature
#19
Tatsuya Ishikawa, Koji Yamaguchi, Hidenori Anami, Masatake Sumi, Tomomi Ishikawa, Takakazu Kawamata
BACKGROUND: Primitive trigeminal artery (PTA) is the most common anomaly of primitive carotid-basilar anastomosis and is associated with cerebrovascular anomalies, such as aneurysm. Large or giant cavernous aneurysm associated with PTA is rare, and the treatment strategies differ in comparison to large or giant aneurysm without PTA. In this article, we report an unusual case of a giant cavernous aneurysm associated with PTA and review treatment strategies for large or giant cavernous aneurysm associated with PTA...
September 14, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28919562/operative-management-of-distal-anterior-cerebral-artery-aneurysms-through-a-mini-anterior-interhemispheric-approach
#20
Alejandro Monroy, Edgar Nathal, Albert L Rhoton
BACKGROUND: Distal anterior cerebral artery (DACA) aneurysms, also referred to as pericallosal artery aneurysms, are present in 1.5 to 9% of all intracranial aneurysms. This study aims to describe the importance of the microsurgical anatomy of the DACA and demonstrate the surgical nuances for handling DACA aneurysms, with a minimally invasive surgical technique METHODS: We retrospectively and descriptively analyzed a series of aneurysm cases performed at the National Institute of Neurology and Neurosurgery-Mexico City...
September 14, 2017: World Neurosurgery
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