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NuRD emt

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https://www.readbyqxmd.com/read/27524420/twist1-promotes-breast-cancer-invasion-and-metastasis-by-silencing-foxa1-expression
#1
Y Xu, L Qin, T Sun, H Wu, T He, Z Yang, Q Mo, L Liao, J Xu
The heterogeneous breast cancers can be classified into different subtypes according to their histopathological characteristics and molecular signatures. Foxa1 expression is linked with luminal breast cancer (LBC) with good prognosis, whereas Twist1 expression is associated with basal-like breast cancer (BLBC) with poor prognosis owing to its role in promoting epithelial-to-mesenchymal transition (EMT), invasiveness and metastasis. However, the regulatory and functional relationships between Twist1 and Foxa1 in breast cancer progression are unknown...
August 15, 2016: Oncogene
https://www.readbyqxmd.com/read/23671646/the-metastasis-associated-gene-mta3-a-component-of-the-mi-2-nurd-transcriptional-repression-complex-predicts-prognosis-of-gastroesophageal-junction-adenocarcinoma
#2
Hongmei Dong, Hong Guo, Liangxi Xie, Geng Wang, Xueyun Zhong, Thaer Khoury, Dongfeng Tan, Hao Zhang
Gastroesophageal junction (GEJ) adenocarcinoma carries a poor prognosis that is largely attributable to early and frequent metastasis. The acquisition of metastatic potential in cancer involves epithelial-to-mesenchymal transition (EMT). The metastasis-associated gene MTA3, a novel component of the Mi-2/NuRD transcriptional repression complex, was identified as master regulator of EMT through inhibition of Snail to increase E-cadherin expression in breast cancer. Here, we evaluated the expression pattern of the components of MTA3 pathway and the corresponding prognostic significance in GEJ adenocarcinoma...
2013: PloS One
https://www.readbyqxmd.com/read/20714342/the-twist-mi2-nurd-protein-complex-and-its-essential-role-in-cancer-metastasis
#3
Junjiang Fu, Li Qin, Tao He, Jun Qin, Jun Hong, Jiemin Wong, Lan Liao, Jianming Xu
The epithelial-mesenchymal transition (EMT) converts epithelial tumor cells into invasive and metastatic cancer cells, leading to mortality in cancer patients. Although TWIST is a master regulator of EMT and metastasis for breast and other cancers, the mechanisms responsible for TWIST-mediated gene transcription remain unknown. In this study, purification and characterization of the TWIST protein complex revealed that TWIST interacts with several components of the Mi2/nucleosome remodeling and deacetylase (Mi2/NuRD) complex, MTA2, RbAp46, Mi2 and HDAC2, and recruits them to the proximal regions of the E-cadherin promoter for transcriptional repression...
February 2011: Cell Research
https://www.readbyqxmd.com/read/17761946/the-transcription-factor-snail-mediates-epithelial-to-mesenchymal-transitions-by-repression-of-estrogen-receptor-alpha
#4
Archana Dhasarathy, Masahiro Kajita, Paul A Wade
The estrogen receptor (ER)-alpha (ESR1) is a key regulatory molecule in mammary epithelial cell development. Loss of ER-alpha in breast cancer is correlated with poor prognosis, increased recurrence after treatment, and an elevated incidence of metastasis. A proposed molecular pathway by which ER-alpha acts to constrain invasive growth in breast cancer cells involves direct, ER-alpha-dependent expression of metastasis-associated protein 3, a cell-type-specific component of the Mi-2/NuRD chromatin remodeling complex...
December 2007: Molecular Endocrinology
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