keyword
MENU ▼
Read by QxMD icon Read
search

CARD9

keyword
https://www.readbyqxmd.com/read/27802154/interplay-of-host-genetics-and-gut-microbiota-underlying-the-onset-and-clinical-presentation-of-inflammatory-bowel-disease
#1
Floris Imhann, Arnau Vich Vila, Marc Jan Bonder, Jingyuan Fu, Dirk Gevers, Marijn C Visschedijk, Lieke M Spekhorst, Rudi Alberts, Lude Franke, Hendrik M van Dullemen, Rinze W F Ter Steege, Curtis Huttenhower, Gerard Dijkstra, Ramnik J Xavier, Eleonora A M Festen, Cisca Wijmenga, Alexandra Zhernakova, Rinse K Weersma
OBJECTIVE: Patients with IBD display substantial heterogeneity in clinical characteristics. We hypothesise that individual differences in the complex interaction of the host genome and the gut microbiota can explain the onset and the heterogeneous presentation of IBD. Therefore, we performed a case-control analysis of the gut microbiota, the host genome and the clinical phenotypes of IBD. DESIGN: Stool samples, peripheral blood and extensive phenotype data were collected from 313 patients with IBD and 582 truly healthy controls, selected from a population cohort...
October 8, 2016: Gut
https://www.readbyqxmd.com/read/27785786/the-genetic-background-of-inflammatory-bowel-disease-from-correlation-to-causality
#2
REVIEW
Werna T C Uniken Venema, Michiel D Voskuil, Gerard Dijkstra, Rinse K Weersma, Eleonora A M Festen
Recent studies have greatly improved our insight into the genetic background of Inflammatory Bowel Disease (IBD). New high throughput technologies and large-scale international collaborations have contributed to the identification of 200 independent genetic risk loci for IBD. However, in most of these loci it is unclear which gene conveys the risk for IBD. More importantly, it is unclear which variant within or near the gene is causal to the disease. Using targeted GWAS, imputation, re-sequencing of risk loci and in silico fine-mapping of densely typed loci, several causal variants have been identified in IBD risk genes, and various pathological pathways have been uncovered...
October 26, 2016: Journal of Pathology
https://www.readbyqxmd.com/read/27783709/correction-the-card9-polymorphisms-rs4077515-rs10870077-and-rs10781499-are-uncoupled-from-susceptibility-to-and-severity-of-pulmonary-tuberculosis
#3
Ioana Streata, January Weiner, Marco Iannaccone, Gayle McEwen, Marius Sorin Ciontea, Marian Olaru, Rosanna Capparelli, Mihai Ioana, Stefan H E Kaufmann, Anca Dorhoi
[This corrects the article DOI: 10.1371/journal.pone.0163662.].
2016: PloS One
https://www.readbyqxmd.com/read/27777981/extrapulmonary-aspergillus-infection-in-patients-with-card9-deficiency
#4
Nikolaus Rieber, Roel P Gazendam, Alexandra F Freeman, Amy P Hsu, Amanda L Collar, Janyce A Sugui, Rebecca A Drummond, Chokechai Rongkavilit, Kevin Hoffman, Carolyn Henderson, Lily Clark, Markus Mezger, Muthulekha Swamydas, Maik Engeholm, Rebecca Schüle, Bettina Neumayer, Frank Ebel, Constantinos M Mikelis, Stefania Pittaluga, Vinod K Prasad, Anurag Singh, Joshua D Milner, Kelli W Williams, Jean K Lim, Kyung J Kwon-Chung, Steven M Holland, Dominik Hartl, Taco W Kuijpers, Michail S Lionakis
Invasive pulmonary aspergillosis is a life-threatening mycosis that only affects patients with immunosuppression, chemotherapy-induced neutropenia, transplantation, or congenital immunodeficiency. We studied the clinical, genetic, histological, and immunological features of 2 unrelated patients without known immunodeficiency who developed extrapulmonary invasive aspergillosis at the ages of 8 and 18. One patient died at age 12 with progressive intra-abdominal aspergillosis. The other patient had presented with intra-abdominal candidiasis at age 9, and developed central nervous system aspergillosis at age 18 and intra-abdominal aspergillosis at age 25...
October 20, 2016: JCI Insight
https://www.readbyqxmd.com/read/27777084/crosstalk-between-the-gut-and-the-liver-via-susceptibility-loci-novel-advances-in-inflammatory-bowel-disease-and-autoimmune-liver-disease
#5
Xinyang Li, Jun Shen, Zhihua Ran
Inflammatory bowel disease (IBD) is an autoimmune disorder characterized by chronic, relapsing intestinal inflammation. Autoimmune liver disease (AILD) may be involved in IBD as an extra-intestinal manifestation (EIM). Epidemiologic and anatomic evidence have demonstrated an intimate crosstalk between the gut and the liver. In this review, we briefly introduced nine groups of susceptibility loci shared by inflammatory bowel and autoimmune liver disease for the first time. The genome-wide association studies (GWAS) evidence of pathways involving crosstalk between the gut and the liver is clarified and explained...
October 21, 2016: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/27684065/the-card9-polymorphisms-rs4077515-rs10870077-and-rs10781499-are-uncoupled-from-susceptibility-to-and-severity-of-pulmonary-tuberculosis
#6
Ioana Streata, January Weiner, Marco Iannaconne, Gayle McEwen, Marius Sorin Ciontea, Marian Olaru, Rosanna Capparelli, Mihai Ioana, Stefan H E Kaufmann, Anca Dorhoi
Genetic variants in the CARD9 gene predispose to inflammatory disorders and chronic infectious diseases. Tuberculosis (TB), a chronic infectious disease affecting the lung, is lethal in Card9-deficient mice. We hypothesized that polymorphisms in the CARD9 gene influence TB progression and disease-associated lung damage in humans. We tested genotype distributions of the CARD9 polymorphisms rs4077515, rs10781499 and rs10870077 in TB patients and healthy subjects in a Caucasian cohort. SNPs were in linkage disequilibrium and none of the haplotypes was significantly enriched in the TB group...
2016: PloS One
https://www.readbyqxmd.com/read/27670879/card9-negatively-regulates-nlrp3-induced-il-1%C3%AE-production-on-salmonella-infection-of-macrophages
#7
Milton Pereira, Panagiotis Tourlomousis, John Wright, Tom P Monie, Clare E Bryant
Interleukin-1β (IL-1β) is a proinflammatory cytokine required for host control of bacterial infections, and its production must be tightly regulated to prevent excessive inflammation. Here we show that caspase recruitment domain-containing protein 9 (CARD9), a protein associated with induction of proinflammatory cytokines by fungi, has a negative role on IL-1β production during bacterial infection. Specifically, in response to activation of the nucleotide oligomerization domain receptor pyrin-domain containing protein 3 (NLRP3) by Salmonella infection, CARD9 negatively regulates IL-1β by fine-tuning pro-IL-1β expression, spleen tyrosine kinase (SYK)-mediated NLRP3 activation and repressing inflammasome-associated caspase-8 activity...
September 27, 2016: Nature Communications
https://www.readbyqxmd.com/read/27558332/tyrosine-kinase-signaling-pathways-in-neutrophils
#8
REVIEW
Krisztina Futosi, Attila Mócsai
Neutrophils play a critical role in antimicrobial host defense, but their improper activation also contributes to inflammation-induced tissue damage. Therefore, understanding neutrophil biology is important for the understanding, diagnosis, and therapy of both infectious and inflammatory diseases. Neutrophils express a large number of cell-surface receptors that sense extracellular cues and trigger various functional responses through complex intracellular signaling pathways. During the last several years, we and others have shown that tyrosine kinases play a critical role in those processes...
September 2016: Immunological Reviews
https://www.readbyqxmd.com/read/27542117/myd88-shapes-vaccine-immunity-by-extrinsically-regulating-survival-of-cd4-t-cells-during-the-contraction-phase
#9
Huafeng Wang, Mengyi Li, Chiung Yu Hung, Meenal Sinha, Linda M Lee, Darin L Wiesner, Vanessa LeBert, Tassanee Lerksuthirat, Kevin Galles, Marulasiddappa Suresh, Anthony L DeFranco, Clifford A Lowell, Bruce S Klein, Marcel Wüthrich
Soaring rates of systemic fungal infections worldwide underscore the need for vaccine prevention. An understanding of the elements that promote vaccine immunity is essential. We previously reported that Th17 cells are required for vaccine immunity to the systemic dimorphic fungi of North America, and that Card9 and MyD88 signaling are required for the development of protective Th17 cells. Herein, we investigated where, when and how MyD88 regulates T cell development. We uncovered a novel mechanism in which MyD88 extrinsically regulates the survival of activated T cells during the contraction phase and in the absence of inflammation, but is dispensable for the expansion and differentiation of the cells...
August 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27456474/subcutaneous-phaeohyphomycosis-caused-by-exophiala-spinifera-in-a-european-patient-with-lymphoma-a-rare-occurrence-case-report-and-literature-review
#10
G Bohelay, S Robert, C Bouges-Michel, M Gerin, A Levy, O Fain, F Caux
Exophiala spinifera is a dematiaceous fungus responsible for rare skin infections presenting as phaeohyphomycosis or chromoblastomycosis which has been primarily reported in tropical and subtropical areas (Asia, South and North America). We report the first case of E. spinifera phaeohyphomycosis in a European patient. The phaeohyphomycosis was limited to the skin, involving the finger of an immunocompromised patient presenting with a large B-cell lymphoma treated by R-mini-CHOP regimen. Remission was initially achieved by surgical excision; however, a local subcutaneous relapse required treatment with itraconazole...
November 2016: Mycoses
https://www.readbyqxmd.com/read/27421992/impairment-of-immune-response-against-dematiaceous-fungi-in-card9-knockout-mice
#11
Weiwei Wu, Ruijun Zhang, Xiaowen Wang, Yinggai Song, Zhengyang Liu, Wenling Han, Ruoyu Li
Dematiaceous fungi are a large group of pathogens that can cause a wide range of diseases in both immunocompetent and immunocompromised hosts. Based on our previous finding of caspase recruitment domain-containing protein 9 (CARD9) mutations in patients with subcutaneous phaeohyphomycosis caused by Phialophora verrucosa (P. verrucosa), we further investigated the exact role of CARD9 in the pathogenesis of phaeohyphomycosis using Card9 knockout (Card9 KO) mice. We showed that Card9 KO mice are profoundly susceptible to P...
October 2016: Mycopathologia
https://www.readbyqxmd.com/read/27363694/polymorphisms-in-the-pattern-recognition-receptor-mincle-gene-clec4e-and-association-with-tuberculosis
#12
Nicholas Bowker, Muneeb Salie, Haiko Schurz, Paul D van Helden, Craig J Kinnear, Eileen G Hoal, Marlo Möller
The mechanisms involved in interactions between Mycobacterium tuberculosis and host innate immune cells determine outcome. Antigen-presenting cells, including macrophages and dendritic cells, express many pattern recognition receptors to identify pathogen-associated molecular patterns, thereby initiating an immune response. A major mycobacterial virulence factor, trehalose-6',6-dimycolate, is recognised by the macrophage-inducible C-type lectin, Mincle, which leads to the activation of the Syk-Card9 signalling pathway in macrophages...
October 2016: Lung
https://www.readbyqxmd.com/read/27343564/baseline-cytokine-profiling-identifies-novel-risk-factors-for-invasive-fungal-disease-among-haematology-patients-undergoing-intensive-chemotherapy-or-haematopoietic-stem-cell-transplantation
#13
M Mansour Ceesay, Shahram Kordasti, Eamaan Rufaie, Nicholas Lea, Melvyn Smith, Jim Wade, Abdel Douiri, Ghulam J Mufti, Antonio Pagliuca
BACKGROUND: Invasive fungal disease (IFD) is a disease of immunocompromised hosts. Cytokines are important mediators of innate and adaptive immune system. The aim of this study was to identify cytokine profiles that correlate with increased risk of IFD. METHODS: We prospectively enrolled 172 adult haematology patients undergoing intensive chemotherapy, immunosuppressive therapy, and haematopoietic stem cell transplantation. Pro-inflammatory cytokine profiling using 30-plex Luminex assay was performed at baseline and during treatment...
September 2016: Journal of Infection
https://www.readbyqxmd.com/read/27237547/new-clinical-phenotypes-of-fungal-infections-in-special-hosts
#14
REVIEW
B Pilmis, A Puel, O Lortholary, F Lanternier
Incidence of invasive fungal infections increases over time with the rise in at-risk populations; in particular, patients with acquired immunodeficiencies due to immunosuppressive therapies such as anti-tumour necrosis factor-α (TNF-α) treatment, cirrhosis or burns. Some primary immunodeficiencies (PID) can also predispose selectively to invasive fungal diseases. Conversely, some atypical fungal diseases can reveal new PID. Deep dermatophytosis, Candida central nervous system infections or gastrointestinal disease, or disseminated phaeohyphomycosis-revealed CARD9 deficiency...
August 2016: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/27222657/primary-immunodeficiencies-associated-with-eosinophilia
#15
REVIEW
Behdad Navabi, Julia Elizabeth Mainwaring Upton
BACKGROUND: Eosinophilia is not an uncommon clinical finding. However, diagnosis of its cause can be a dilemma once common culprits, namely infection, allergy and reactive causes are excluded. Primary immunodeficiency disorders (PID) are among known differentials of eosinophilia. However, the list of PIDs typically reported with eosinophilia is small and the literature lacks an inclusive list of PIDs which have been reported with eosinophilia. This motivated us to review the literature for all PIDs which have been described to have elevated eosinophils as this may contribute to an earlier diagnosis of PID and further the understanding of eosinophilia...
2016: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/27188821/ibd-dysbiosis-underlies-card9-risk-alleles-in-colitis
#16
Charlotte Ridler
No abstract text is available yet for this article.
June 2016: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27158904/card9-impacts-colitis-by-altering-gut-microbiota-metabolism-of-tryptophan-into-aryl-hydrocarbon-receptor-ligands
#17
Bruno Lamas, Mathias L Richard, Valentin Leducq, Hang-Phuong Pham, Marie-Laure Michel, Gregory Da Costa, Chantal Bridonneau, Sarah Jegou, Thomas W Hoffmann, Jane M Natividad, Loic Brot, Soraya Taleb, Aurélie Couturier-Maillard, Isabelle Nion-Larmurier, Fatiha Merabtene, Philippe Seksik, Anne Bourrier, Jacques Cosnes, Bernhard Ryffel, Laurent Beaugerie, Jean-Marie Launay, Philippe Langella, Ramnik J Xavier, Harry Sokol
Complex interactions between the host and the gut microbiota govern intestinal homeostasis but remain poorly understood. Here we reveal a relationship between gut microbiota and caspase recruitment domain family member 9 (CARD9), a susceptibility gene for inflammatory bowel disease (IBD) that functions in the immune response against microorganisms. CARD9 promotes recovery from colitis by promoting interleukin (IL)-22 production, and Card9(-/-) mice are more susceptible to colitis. The microbiota is altered in Card9(-/-) mice, and transfer of the microbiota from Card9(-/-) to wild-type, germ-free recipients increases their susceptibility to colitis...
June 2016: Nature Medicine
https://www.readbyqxmd.com/read/27116191/erratum-to-chronic-and-invasive-fungal-infections-in-a-family-with-card9-deficiency
#18
Ana Karina Alves de Medeiros, Evelyn Lodewick, Delfien J A Bogaert, Filomeen Haerynck, Sabine Van Daele, Bart Lambrecht, Sara Bosma, Laure Vanderdonckt, Olivier Lortholary, Mélanie Migaud, Jean-Laurent Casanova, Anne Puel, Fanny Lanternier, Jo Lambert, Lieve Brochez, Melissa Dullaers
No abstract text is available yet for this article.
April 26, 2016: Journal of Clinical Immunology
https://www.readbyqxmd.com/read/27092298/mechanistic-insights-into-the-role-of-c-type-lectin-receptor-card9-signaling-in-human-antifungal-immunity
#19
REVIEW
Rebecca A Drummond, Michail S Lionakis
Human CARD9 deficiency is an autosomal recessive primary immunodeficiency disorder caused by biallelic mutations in the gene CARD9, which encodes a signaling protein that is found downstream of many C-type lectin receptors (CLRs). CLRs encompass a large family of innate recognition receptors, expressed predominantly by myeloid and epithelial cells, which bind fungal carbohydrates and initiate antifungal immune responses. Accordingly, human CARD9 deficiency is associated with the spontaneous development of persistent and severe fungal infections that primarily localize to the skin and subcutaneous tissue, mucosal surfaces and/or central nervous system (CNS)...
2016: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/27038042/moraxella-catarrhalis-induces-ceacam3-syk-card9-dependent-activation-of-human-granulocytes
#20
A Heinrich, K A Heyl, E Klaile, M M Müller, T E Klassert, A Wiessner, K Fischer, R R Schumann, U Seifert, K Riesbeck, A Moter, B B Singer, S Bachmann, H Slevogt
The human restricted pathogen Moraxella catarrhalis is an important causal agent for exacerbations in chronic obstructive lung disease (COPD) in adults. In such patients, increased numbers of granulocytes are present in the airways, which correlate with bacteria-induced exacerbations and severity of the disease. Our study investigated whether the interaction of M. catarrhalis with the human granulocyte-specific carcinoembryonic antigen-related cell adhesion molecule (CEACAM)-3 is linked to NF-κB activation, resulting in chemokine production...
March 31, 2016: Cellular Microbiology
keyword
keyword
38053
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"