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optical coherence tomograph

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https://www.readbyqxmd.com/read/28644304/abnormal-retinal-reflectivity-to-short-wavelength-light-in-type-2-idiopathic-macular-telangiectasia
#1
Ferenc B Sallo, Irene Leung, Meike Zeimer, Traci E Clemons, Adam M Dubis, Marcus Fruttiger, Daniel Pauleikhoff, Emily Y Chew, Catherine Egan, Tunde Peto, Alan C Bird
PURPOSE: Macular telangiectasia Type 2 (MacTel) is a bilateral, progressive, potentially blinding retinal disease characterized by vascular and neurodegenerative signs, including an increased parafoveal reflectivity to blue light. Our aim was to investigate the relationship of this sign with other signs of macular telangiectasia Type 2 in multiple imaging modalities. METHODS: Participants were selected from the MacTel Type 2 study, based on a confirmed diagnosis and the availability of images...
June 21, 2017: Retina
https://www.readbyqxmd.com/read/28625685/objective-quantification-of-anterior-chamber-inflammation-measuring-cells-and-flare-by-anterior-segment-optical-coherence-tomography
#2
Alessandro Invernizzi, Sylvia Marchi, Raffaella Aldigeri, Valentina Mastrofilippo, Fabiana Viscogliosi, Annamaria Soldani, Chantal Adani, Elena Garoli, Francesco Viola, Luigi Fontana, Peter McCluskey, Luca Cimino
PURPOSE: To assess the ability of swept-source (SS) optical coherence tomography (OCT) of the anterior segment (AS) to measure anterior chamber (AC) inflammation (both flare and cells) objectively. To compare OCT-derived inflammatory indices with standard techniques. DESIGN: Prospective evaluation of a diagnostic test. PARTICIPANTS: Patients diagnosed with anterior uveitis (active or inactive) and controls. METHODS: Participants underwent an AC inflammation evaluation including: clinical cell and flare grading and laser flare photometry (LFP)...
June 16, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28614337/dual-axis-optical-coherence-tomography-for-deep-tissue-imaging
#3
Yang Zhao, Will J Eldridge, Jason R Maher, Sanghoon Kim, Michael Crose, Mohamed Ibrahim, Howard Levinson, Adam Wax
We have developed dual-axis optical coherence tomography (DA-OCT) which enables deep tissue imaging by using a novel off-axis illumination/detection configuration. DA-OCT offers a 100-fold speed increase compared with its predecessor, multispectral multiple-scattering low coherence interferometry (ms2/LCI), by using a new beam scanning mechanism based on a microelectro-mechanical system (MEMS) mirror. The data acquisition scheme was altered to take advantage of this scanning speed, producing tomographic images at a rate of 4 frames (B-scans) per second...
June 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/28613221/clinicopathologic-correlation-of-retinal-angiomatous-proliferation-treated-with-ranibizumab
#4
Alison H Skalet, Audra K Miller, Michael L Klein, Andreas K Lauer, David J Wilson
PURPOSE: To describe histopathologic features of an eye with retinal angiomatous proliferation (RAP) secondary to age-related macular degeneration treated with serial ranibizumab injections and to correlate these findings with spectral domain optical coherence tomography. METHODS: Histopathologic features from serial sections through the globe of a 93-year-old man with age-related macular degeneration were studied and compared with spectral domain optical coherence tomography images obtained 7 weeks before his death...
April 26, 2017: Retina
https://www.readbyqxmd.com/read/28613216/polypoidal-choroidal-vasculopathy-upon-optical-coherence-tomographic-angiography
#5
Szy Yann Chan, Qian Wang, Ya Xing Wang, Xue Hui Shi, Jost B Jonas, Wen Bin Wei
PURPOSE: To study polypoidal lesions and branching choroidal vascular networks in eyes with polypoidal choroidal vasculopathy by optical coherence tomography (OCT)-based angiography (OCTA). METHODS: In the observational cross-sectional study, patients with polypoidal choroidal vasculopathy, as diagnosed by indocyanine green angiography, underwent OCTA. RESULTS: Thirty-two eyes of 31 patients with an age of 61.1 ± 7.6 years were included. Branching choroidal vascular networks were detected by indocyanine green angiography and OCTA in 25 of 32 (78 ± 73%) and in 30 of 32 (94 ± 4%) eyes, respectively, with a marginally significant difference (P = 0...
May 22, 2017: Retina
https://www.readbyqxmd.com/read/28596634/a-three-step-reconstruction-method-for-fluorescence-molecular-tomography-based-on-compressive-sensing
#6
Yansong Zhu, Abhinav K Jha, Jakob K Dreyer, Hanh N D Le, Jin U Kang, Per E Roland, Dean F Wong, Arman Rahmim
Fluorescence molecular tomography (FMT) is a promising tool for real time in vivo quantification of neurotransmission (NT) as we pursue in our BRAIN initiative effort. However, the acquired image data are noisy and the reconstruction problem is ill-posed. Further, while spatial sparsity of the NT effects could be exploited, traditional compressive-sensing methods cannot be directly applied as the system matrix in FMT is highly coherent. To overcome these issues, we propose and assess a three-step reconstruction method...
January 28, 2017: Proceedings of SPIE
https://www.readbyqxmd.com/read/28591276/comparison-of-optical-coherence-tomographic-findings-between-behcet-disease-patients-with-and-without-ocular-involvement-and-healthy-subjects
#7
Ayse Sevgi Karadag, Burak Bilgin, Merih Banu Soylu
Purpose: We aimed to compare the retinal nerve fiber layer, ganglion cell layer, inner plexiform layer, and the choroid thickness between patients with Behcet disease and healthy subjects by using spectral domain optical coherence tomography (SD-OCT). Methods: Ninety eyes of 45 healthy subjects and 104 eyes of 52 patients with Behcet disease were included in this study. Rheumatoid factor and C-reactive protein levels were measured by blood testing in the patients...
March 2017: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/28579843/optical-coherence-tomographic-angiography-imaging-in-age-related-macular-degeneration
#8
REVIEW
Jeffrey Ma, Ria Desai, Peter Nesper, Manjot Gill, Amani Fawzi, Dimitra Skondra
Optical coherence tomographic angiography (OCTA) is emerging as a rapid, noninvasive imaging modality that can provide detailed structural and flow information on retinal and choroidal vasculature. This review contains an introduction of OCTA and summarizes the studies to date on OCTA imaging in age-related macular degeneration.
2017: Ophthalmology and Eye Diseases
https://www.readbyqxmd.com/read/28576456/clinical-fundoscopic-tomographic-and-angiographic-characteristics-of-dome-shaped-macula-classified-by-bulge-height
#9
J Fajardo Sánchez, C E Chau Ramos, J A Roca Fernández, J L Urcelay Segura
OBJECTIVE: To classify dome shaped macula cases by their bulge height (BH). To analyse the characteristics associated with the groups formed by this classification. METHODS: Observational, descriptive and cross-sectional study on 15 selected eyes with dome shaped macula and high myopia. Using Caillaux method and optical coherence tomography images, 3groups were determined by their BH: low (50-350 μ), medium (351-650 μ), and high (>650 μ), and a study of visual acuity, axial length, presence of subfoveal serous detachment, and images by fluorescein angiography and optic coherence tomography, as main variables...
May 30, 2017: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/28576211/morpho-functional-analysis-of-stargardt-disease-for-reading
#10
Paola Sasso, Andrea Scupola, Valeria Silvestri, Filippo M Amore, Edoardo Abed, Luigi Calandriello, Gabriela Grimaldi, Aldo Caporossi
OBJECTIVE: To analyze Stargardt disease (STGD) by morpho-functional examination and investigate the relationship between morpho-functional measures and reading performance. DESIGN: Observational case series study. PARTICIPANTS: Fifteen patients with STGD. METHODS: Twenty-six eyes of 15 patients underwent complete ophthalmic evaluation. Spectral domain optical coherence tomography, fundus autofluorescence (FAF), best corrected visual acuity (BCVA), and microperimetric examinations were performed...
June 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/28557829/progressive-decrease-of-peripapillary-angioflow-vessel-density-during-structural-and-visual-field-progression-in-early-primary-open-angle-glaucoma
#11
Gábor Holló
PURPOSE: To present a case of early primary open-angle glaucoma in which retinal nerve fiber layer thickness (RNFLT), ganglion cell complex (GCC), and visual field progression were accompanied with significant progression of peripapillary angioflow vessel density (PAFD) measured with optical coherence tomographic angiography. METHODS: A 68-year-old female patient who was under topical intraocular pressure (IOP) lowering medication for 20 years for ocular hypertension of the right and preperimetric primary open-angle glaucoma of the left eye (with reproducible inferotemporal and superotemporal neuroretinal rim and RNFL loss) was prospectively imaged with the AngioVue OCT for RNFLT, GCC thickness, and PAFD, and investigated with the Octopus Normal G2 visual field test on the same days at 6-month intervals for 18 months, while the IOP of the left eye escaped from control...
May 26, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28541963/correlation-of-structural-and-functional-outcome-measures-in-a-phase-one-trial-of-ciliary-neurotrophic-factor-in-type-2-idiopathic-macular-telangiectasia
#12
Ferenc B Sallo, Irene Leung, Traci E Clemons, Tunde Peto, Emily Y Chew, Daniel Pauleikhoff, Alan C Bird
PURPOSE: Macular telangiectasia Type 2 is a bilateral, progressive, potentially blinding retinal disease characterized by both vascular and neurodegenerative signs. Both the area of the break in the ellipsoid zone seen in "en face" optical coherence tomographic (OCT) images and microperimetric focal retinal sensitivity loss have been proposed as potential measures of progression in macular telangiectasia. The authors aimed to assess the characteristics and interrelationship of these structural and functional disease markers from the data collected in a phase one clinical trial of ciliary neurotrophic factor in macular telangiectasia...
May 23, 2017: Retina
https://www.readbyqxmd.com/read/28527768/randomized-comparison-of-absorb-bioresorbable-vascular-scaffold-and-mirage-microfiber-sirolimus-eluting-scaffold-using-multimodality-imaging
#13
Erhan Tenekecioglu, Patrick W Serruys, Yoshinobu Onuma, Ricardo Costa, Daniel Chamié, Yohei Sotomi, Ting-Bin Yu, Alexander Abizaid, Houng-Bang Liew, Teguh Santoso
OBJECTIVES: The primary objective of this study was to evaluate the safety and effectiveness of the Mirage bioresorbable microfiber sirolimus-eluting scaffold compared with the Absorb bioresorbable vascular scaffold in the treatment of stenotic target lesions located in native coronary arteries, ranging from ≥2.25 to ≤4.0 mm in diameter. Secondary objectives were to establish the medium-term safety, effectiveness, and performance of the Mirage device. BACKGROUND: The current generation of bioresorbable scaffolds has several limitations, such as thick square struts with large footprints that preclude their deep embedment into the vessel wall, resulting in protrusion into the lumen with microdisturbance of flow...
May 11, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28521901/noninvasive-imaging-analysis-of-biological-tissue-associated-with-laser-thermal-injury
#14
Cheng-Jen Chang, De-Yi Yu, Yen-Chang Hsiao, Kuang-Hua Ho
BACKGROUND: The purpose of our study is to use a noninvasive tomographic imaging technique with high spatial resolution to characterize and monitor biological tissue responses associated with laser thermal injury. METHODS: Optical doppler tomography (ODT) combines laser doppler flowmetry (LDF) with optical coherence tomography (OCT) to obtain high resolution tomographic velocity and structural images of static and moving constituents in highly scattering biological tissues...
April 2017: Biomedical Journal
https://www.readbyqxmd.com/read/28520583/focal-capillary-dropout-associated-with-optic-disc-drusen-using-optical-coherence-tomographic-angiography
#15
Eric D Gaier, Joseph F Rizzo, John B Miller, Dean M Cestari
Optic disc drusen may be a cause of visual field defects and visual loss. The mechanism by which this occurs is unclear. We report a patient who developed decreased vision in the right eye and was found to have a heavy burden of superficial optic disc drusen. Optical coherence tomography (OCT) confirmed focal retinal nerve fiber layer thinning that corresponded with the distribution of drusen. OCT angiography, with superficial laminar segmentation, showed focal capillary attenuation overlying the most prominent drusen...
May 4, 2017: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/28501447/comparison-of-quantitative-measurement-of-foveal-avascular-zone-and-macular-vessel-density-in-eyes-of-children-with-amblyopia-and-healthy-controls-an-optical-coherence-tomography-angiography-study
#16
Ihsan Yilmaz, Osman Bulut Ocak, Basak Saracoglu Yilmaz, Aslı Inal, Birsen Gokyigit, Muhittin Taskapili
PURPOSE: To quantify vessel density of superficial capillary plexus (SCP), deep capillary plexus (DCP), and the foveal avascular zone (FAZ) of children's amblyopic eyes and to compare the measurements with those of companion eyes and age-matched controls. METHODS: Fifteen patients with strabismic amblyopia, and 15 age-matched controls were included in this cross-sectional study. SCP, DCP, and FAZ were measured via optical coherence tomographic angiography (OCTA)...
May 10, 2017: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/28497619/change-in-over-refraction-after-scleral-lens-settling-on-average-corneas
#17
Chelsea Bray, Stephanie Britton, Debby Yeung, Lacey Haines, Luigina Sorbara
PURPOSE: The purpose of this study was to determine the change in over-refraction, if any, after a scleral lens settled on the eye for 6-8 h. METHODS: Sixteen patients of varying refractive errors and normal corneal curvatures (measured with Pentacam(™) Oculus) were fitted with trial Mini-Scleral Design (MSD) scleral lenses (15.8 mm diameter) in one eye. The sagittal depths of the scleral lenses were selected by adding 350 μm to the corneal sagittal heights measured at a chord length of 15 mm with the Visante(™) optical coherence tomographer (OCT) anterior segment scans and picking the closest available trial lens in the set...
May 12, 2017: Ophthalmic & Physiological Optics: the Journal of the British College of Ophthalmic Opticians (Optometrists)
https://www.readbyqxmd.com/read/28497336/the-overlapping-spectrum-of-flat-irregular-pigment-epithelial-detachment-investigated-by-optical-coherence-tomography-angiography
#18
Francesco Pichi, Mariachiara Morara, Chiara Veronese, Antonio P Ciardella
PURPOSE: To describe the OCT angiography characteristics of flat irregular pigment epithelial detachments (PEDs), an overlapping tomographic feature of various macular disorders. METHODS: Consecutive patients with a dimpled retinal pigment epithelium profile on OCT, referred for a second opinion, were enrolled. Fluorescein (FA) and indocyanine green angiography (ICGA) were performed in all patients and compared to previous examinations, when available. In all patients, enhanced depth imaging-OCT and OCT angiography were performed upon referral and at subsequent follow-ups...
May 11, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28486219/higher-numbers-of-hyperreflective-foci-seen-in-the-vitreous-on-spectral-domain-optical-coherence-tomographic-images-in-eyes-with-more-severe-diabetic-retinopathy
#19
Takahiro Mizukami, Yosuke Hotta, Naomichi Katai
PURPOSE: The aim of this study was to determine whether spectral-domain optical coherence tomography (SD-OCT) can detect and quantify the number of hyperreflective foci attached to the retina and in the vitreous of patients at different stages of diabetic retinopathy (DR). METHODS: The medical charts of 929 eyes of 465 patients who had undergone SD-OCT were reviewed. The number of hyperreflective foci in the vitreous and attached to the retina was determined in the SD-OCT images...
May 10, 2017: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/28469483/correlation-between-ischemic-retinal-accidents-and-radial-peripapillary-capillaries-in-the-optic-nerve-using-optical-coherence-tomographic-angiography-observations-in-6-patients
#20
Marta Cerdà-Ibáñez, Antonio Duch-Samper, Rodrigo Clemente-Tomás, Raúl Torrecillas-Picazo, Noemí Ruiz Del Río, Laura Manfreda-Dominguez
BACKGROUND: Perfusion of the optic nerve has been widely studied using fluorescein angiography (FAG), which is currently regarded as the criterion standard. However, FAG has adverse effects associated with intravenous contrast administration and is limited in its capacity to characterize and stratify the different vascular layers of the optic nerve and retina. The use of new imaging techniques, such as optical coherence tomographic angiography (Angio-OCT), is therefore important. AIM: A qualitative description is made of the vascular layers of the optic nerve and of how vascular events affect radial peripapillary capillaries (RPC)...
2017: Ophthalmology and Eye Diseases
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