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https://www.readbyqxmd.com/read/29446615/leveraging-engineering-of-cells-for-drug-delivery
#1
Zhaowei Chen, Quanyin Hu, Zhen Gu
Cell therapy has become a momentum-gathering treatment strategy for a variety of diseases, including cancer, diabetes, hemophilia, and cardiomyopathy. However, clinical applications of conventional cell therapies have often been compromised by rapid decline in viability and function of the transplanted cells due to host recognition and subsequent foreign body rejection. Along this line, cell engineering technologies such as cell encapsulation within microcapsules and immobilization in porous scaffolds have been implemented to address the immunosuppression concerns...
February 15, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29444375/the-efficacy-and-safety-of-non-pharmacological-therapies-for-the-treatment-of-acne-vulgaris-a-systematic-review-and-best-evidence-synthesis
#2
F M C de Vries, A M Meulendijks, R J Driessen, A A van Dooren, E P M Tjin, P C M van de Kerkhof
BACKGROUND: Acne vulgaris is a multifaceted skin disorder, affecting more than 85% of young individuals worldwide. Pharmacological therapy is not always desirable because of the development of antibiotic resistance or the potential risk of adverse effects. Non-pharmacological therapies can be viable alternatives for conventional therapies. However, sufficient evidence based support in the efficacy and safety of non-pharmacological therapies is lacking. OBJECTIVE: To assess the efficacy and safety of several non-pharmacological therapies in the treatment of acne vulgaris...
February 14, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29432892/local-dermal-delivery-of-cyclosporin-a-a-hydrophobic-and-high-molecular-weight-drug-using-dissolving-microneedles
#3
Hye-Rin Jeong, Ji-Yeon Kim, Sang-Nyun Kim, Jung-Hwan Park
Dissolving microneedles (MN) containing cyclosporin A (CyA) were prepared for local delivery of CyA into the dermal layer. The efficacy of using MN to deliver CyA, an insoluble and high molecular weight drug, was observed and compared with oral administration of solubilized CyA. Microneedles containing CyA (CyA MN) were prepared using a closed, low-temperature molding process. The mechanical properties of CyA MN and phase separation were studied regarding the content of CyA. CyA MN were inserted into porcine skin for a predetermined time, and the dissolution and delivered amount of CyA were measured in vitro with an optical microscope and high-performance liquid chromatography (HPLC) analysis of the extracted CyA...
February 9, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29430629/recent-advances-and-development-in-epidermal-and-dermal-drug-deposition-enhancement-technology
#4
Babar Iqbal, Javed Ali, Sanjula Baboota
Skin is the largest and easily accessible organ of the body. Increases in incidences of dermatological disorders, demand for drug targeting, and patient compliance have increased the popularity of topical drug delivery amongst the people. However, drug delivery across the skin is still a challenge for researchers because permeation of maximum drugs is hindered by the upper layer of the epidermis (stratum corneum). Several approaches like use of chemical permeation enhancers and physical methods such as sonophoresis, iontophoresis, electroporation, microneedles, etc...
February 12, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29425769/combined-use-of-nanocarriers-and-physical-methods-for-percutaneous-penetration-enhancement
#5
Nina Dragicevic, Howard Maibach
Dermal and transdermal drug delivery (due to its non-invasiveness, avoidance of the first-pass metabolism, controlling the rate of drug input over a prolonged time, etc.) have gained significant acceptance. Several methods are employed to overcome the permeability barrier of the skin, improving drug penetration into/through skin. Among chemical penetration enhancement methods, nanocarriers have been extensively studied. When applied alone, nanocarriers mostly deliver drugs to skin and can be used to treat skin diseases...
February 6, 2018: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29417843/microneedles-containing-cross-linked-hyaluronic-acid-particulates-for-control-of-degradation-and-swelling-behavior-after-administration-into-skin
#6
Jun-Tae Choi, Sangjin Park, Jung-Hwan Park
Microneedles (MN) containing cross-linked hyaluronic acid (X-linked HA) particulates were prepared to control the degradation and swelling behavior after transdermal drug delivery. The X-linked HA particulates were prepared by cross-linking HA chains and then passing the particulates through a sieve. Then, microneedles were prepared by micromolding method. The rheological properties of X-linked HA were studied. The penetration success rate, mechanical failure, and dissolution rate of microneedles containing only hyaluronic acid (HA MN) and microneedles containing X-linked HA were compared...
February 8, 2018: Journal of Drug Targeting
https://www.readbyqxmd.com/read/29408519/using-a-simple-equation-to-predict-the-microporation-enhanced-transdermal-drug-flux
#7
Alexey S Rzhevskiy, Krishna Telaprolu, Yousuf H Mohammed, Jeffrey E Grice, Michael S Roberts, Yuri G Anissimov
The mathematical model describing drug flux through microporated skin was previously developed. Based on this model, two mathematical equations can be used to predict the microporatio-enhanced transdermal drug flux: the complex primal equation containing a variety of experimentally-determined variables, and the simplified straightforward equation. In this study, experimental transdermal fluxes of three corticosteroids through split-thickness human skin treated with a microneedle roller were measured, and the values of fluxes compared with those predicted using both the more complex and simplified equations...
January 31, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29408182/polymeric-microneedles-for-transdermal-protein-delivery
#8
Yanqi Ye, Jicheng Yu, Di Wen, Anna R Kahkoska, Zhen Gu
The intrinsic properties of therapeutic proteins present a major impediment for transdermal delivery, including their relatively large molecule size and susceptibility to degradation. One solution is to utilize microneedles (MNs), which are capable of painlessly traversing the stratum corneum and directly translocating protein drugs into the systematic circulation. MNs can be designed to incorporate appropriate structural materials as well as therapeutics or formulations with tailored physicochemical properties...
January 30, 2018: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29407146/microneedles-fabricated-from-alginate-and-maltose-for-transdermal-delivery-of-insulin-on-diabetic-rats
#9
Yang Zhang, Guohua Jiang, Weijiang Yu, Depeng Liu, Bin Xu
To reduce the inconvenient and painful of subcutaneous needle injection, the calcium ion cross-linked alginate/maltose (Ca2+/Alg-Mal) composite microneedles have been fabricated by a template method. The as-prepared microneedles exhibited strong mechanical properties with the highest failure force around 0.41N/needle. The biological activity and stability of loaded insulin in microneedles were investigated. Due to the good mechanical properties and excellent biocompatibility, the as-prepared microneedles have been applied for transdermal delivery of insulin on diabetic Sprague-Dawley (SD) rat models in vivo...
April 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29406491/prolonged-inflammatory-reaction-after-fractional-radiofrequency-microneedle-treatment
#10
Dong Hye Suh, Min Young Lee, Sang-Jun Lee, Kye Yong Song, Ji Yeon Byun
No abstract text is available yet for this article.
February 5, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29403182/management-of-stretch-marks-with-a-focus-on-striae-rubrae
#11
REVIEW
Uwe Wollina, Alberto Goldman
Stretch marks are one of the most common benign cutaneous lesions and encountered esthetic problems. Striae rubrae and striae albae can be differentiated on the basis of clinical appearance. Histologically, disturbances of the dermal fiber network and local expression of receptors for sexual steroids have been detected. The epidermal changes are secondary. Prevention of stretch marks using topical ointments and oils is debatable. Treatment of striae rubrae by lasers and light devices improves appearance. Microneedling and non-ablative and fractionated lasers have been used...
July 2017: Journal of Cutaneous and Aesthetic Surgery
https://www.readbyqxmd.com/read/29366416/finasteride-topical-delivery-systems-for-androgenetic-alopecia
#12
Muhammad Zia Ullah Khan, Shujaat Ali Khan, Muhammad Ubaid, Aamna Shah, Rozina Kousar, Ghulam Murtaza
Androgenetic alopecia, generally recognized as male pattern baldness, is a gradually developing medical and physiological change, which is manifested by continuous hair-loss from scalp. Finasteride (4-aza-3-oxosteroid) is a potent anti-baldness compound that selectively and competitively inhibits the 5α-reductase isoenzymes. Prolonged oral use of finasteride leads to the emergence of sexual disorders including decrease in libido, gynecomastia, erectile dysfunction, ejaculation disorder, orgasm disorders and mood disturbances...
January 23, 2018: Current Drug Delivery
https://www.readbyqxmd.com/read/29358594/intra-retinal-arterial-cannulation-using-a-microneedle-for-central-retinal-artery-occlusion
#13
Kazuaki Kadonosono, Shin Yamane, Maiko Inoue, Tadashi Yamakawa, Eiichi Uchio
Central retinal artery occlusion (CRAO) is a severe disease, often causing blindness. We evaluated the efficacy and safety of a surgical procedure for the treatment of acute CRAO in which retinal arterial cannulation with tissue plasminogen activator (tPA) is performed. The surgical procedure consisted of vitrectomy followed by cannulation of the central retinal artery and injection of tPA (200 μg) using a 47-gauge microneedle. Thirteen CRAO patients were treated within 48 hours of the onset of symptoms...
January 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29355656/3d-printing-applications-for-transdermal-drug-delivery
#14
Sophia N Economidou, Dimitrios A Lamprou, Dennis Douroumis
The role of two and three-dimensional printing as a fabrication technology for sophisticated transdermal drug delivery systems is explored in literature. 3D printing encompasses a family of distinct technologies that employ a virtual model to produce a physical object through numerically controlled apparatuses. The applicability of several printing technologies has been researched for the direct or indirect printing of microneedle arrays or for the modification of their surface through drug-containing coatings...
January 17, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29350125/current-management-migraine-headache
#15
Stephen D Silberstein
Migraine varies in its frequency, severity, and impact; treatment should consider these variations and the patient's needs and goals. Migraine pharmacologic treatment may be acute (abortive) or preventive (prophylactic), and patients often require both. New medication devices are available or in development, including an intracutaneous, microneedle system of zolmitriptan and sumatriptan, and breath-powered powder sumatriptan intranasal treatment. Lasmiditan, a 5-HT1F receptor agonist, is in development for acute treatment, as are small molecule calcitonin gene-related peptide (CGRP) receptor antagonists (Gepants) for acute and preventive treatment...
December 2017: CNS Spectrums
https://www.readbyqxmd.com/read/29348670/intradermal-delivery-of-stat3-sirna-to-treat-melanoma-via-dissolving-microneedles
#16
Jingtong Pan, Wenyi Ruan, Mengyao Qin, Yueming Long, Tao Wan, Kaiyue Yu, Yuanhao Zhai, Chuanbin Wu, Yuehong Xu
Hyperactivity of signal transducer and activity of transcription 3 (STAT3) plays a crucial role in melanoma invasion and metastasis. Gene therapy applying siRNA targeting STAT3 is a potential therapeutic strategy for melanoma. In this article, we first fabricated safe and novel dissolving microneedles (MNs) for topical application of STAT3 siRNA to enhance the skin penetration of siRNA and used polyethylenimine (PEI, 25 kDa) as carrier to improve cellular uptake of siRNA. The results showed that MNs can effectively penetrate skin and rapidly dissolve in the skin...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29348573/exendin-4-encapsulated-dissolving-microneedle-arrays-for-efficient-treatment-of-type-2-diabetes
#17
Shayan Fakhraei Lahiji, Yoojung Jang, Inyoung Huh, Huisuk Yang, Mingyu Jang, Hyungil Jung
Dissolving microneedles (DMNs) are microscopic needles capable of delivering encapsulated compounds and releasing them into the skin in a minimally invasive manner. Most studies indicate that encapsulating therapeutics in DMNs is an efficacious approach; however, the importance of evaluating the activity of encapsulated compounds, during the fabrication process, has not been examined in detail. Conducting an analysis of thermal, chemical, and physical stress factors, including temperature, pH, and the interaction of the polymer and therapeutics mixture during preparation, is essential for retaining the activity of encapsulated therapeutics during and after fabrication...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29346488/a-subretinal-cell-delivery-method-via-suprachoroidal-access-in-minipigs-safety-and-surgical-outcomes
#18
Marc D de Smet, Jessica L Lynch, Nadine S Dejneka, Michael Keane, I John Khan
Purpose: This study evaluated a new subretinal method for delivery of human or pig umbilical tissue-derived cells (hUTC or pUTC, respectively) using a novel subretinal injection cannula and suprachoroidal approach in Göttingen minipig eyes. hUTC (palucorcel) are currently under development for treating geographic atrophy in humans. Methods: Twenty-four Göttingen minipigs (divided into eight groups) were subretinally administered palucorcel, pUTC, or vehicle. In some cases, fluorescently labeled cells and vehicle were administered...
January 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29345430/wearable-wireless-tyrosinase-bandage-and-microneedle-sensors-toward-melanoma-screening
#19
Bianca Ciui, Aida Martin, Rupesh K Mishra, Barbara Brunetti, Tatsuo Nakagawa, Thomas J Dawkins, Mengjia Lyu, Cecilia Cristea, Robert Sandulescu, Joseph Wang
Wearable bendable bandage-based sensor and a minimally invasive microneedle biosensor are described toward rapid screening of skin melanoma. These wearable electrochemical sensors are capable of detecting the presence of the tyrosinase (TYR) enzyme cancer biomarker in the presence of its catechol substrate, immobilized on the transducer surface. In the presence of the surface TYR biomarker, the immobilized catechol is rapidly converted to benzoquinone that is detected amperometrically, with a current signal proportional to the TYR level...
January 18, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29320590/treatment-of-d%C3%A3-colletage-photoaging-with-fractional-microneedling-radiofrequency
#20
Alexis Lyons, Jillian Roy, Jennifer Herrmann, Lisa Chipps
OBJECTIVES: The objective of this study was to examine the efficacy and safety of a novel fractional microneedling radiofrequency device to improve the appearance of rhytides and skin laxity of the décolletage. METHODS: Twelve subjects received a total of three fractional microneedling radiofrequency treatments with Endymed Intensif (EndyMed Ltd., Cesarea, Israel) at least three weeks apart. Primary outcome measure was clinical efficacy quantified by a patient survey to assess treatment satisfaction as well as a physician Global Aesthetic Improvement Scale (GAIS)...
January 1, 2018: Journal of Drugs in Dermatology: JDD
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