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Microneedling

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https://www.readbyqxmd.com/read/29677369/targeted-drug-delivery-in-the-suprachoroidal-space-by-swollen-hydrogel-pushing
#1
Jae Hwan Jung, Patcharin Desit, Mark R Prausnitz
Purpose: The purpose is to target model drug particles to the posterior region of the suprachoroidal space (SCS) of the eye controlled via pushing by hydrogel swelling. Methods: A particle formulation containing 1% hyaluronic acid (HA) with fluorescent polymer particles and a hydrogel formulation containing 4% HA were introduced in a single syringe as two layers without mixing, and injected sequentially into the SCS of the rabbit eye ex vivo and in vivo using a microneedle...
April 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29674950/decoding-speech-with-integrated-hybrid-signals-recorded-from-the-human-ventral-motor-cortex
#2
Kenji Ibayashi, Naoto Kunii, Takeshi Matsuo, Yohei Ishishita, Seijiro Shimada, Kensuke Kawai, Nobuhito Saito
Restoration of speech communication for locked-in patients by means of brain computer interfaces (BCIs) is currently an important area of active research. Among the neural signals obtained from intracranial recordings, single/multi-unit activity (SUA/MUA), local field potential (LFP), and electrocorticography (ECoG) are good candidates for an input signal for BCIs. However, the question of which signal or which combination of the three signal modalities is best suited for decoding speech production remains unverified...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29666252/mechanisms-of-sampling-interstitial-fluid-from-skin-using-a-microneedle-patch
#3
Pradnya P Samant, Mark R Prausnitz
Although interstitial fluid (ISF) contains biomarkers of physiological significance and medical interest, sampling of ISF for clinical applications has made limited impact due to a lack of simple, clinically useful techniques that collect more than nanoliter volumes of ISF. This study describes experimental and theoretical analysis of ISF transport from skin using microneedle (MN) patches and demonstrates collection of >1 µL of ISF within 20 min in pig cadaver skin and living human subjects using an optimized system...
April 16, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29663698/comparative-study-of-two-droplet-based-dissolving-microneedle-fabrication-methods-for-skin-vaccination
#4
Chisong Lee, Hongil Kim, Suyong Kim, Shayan F Lahiji, Na-Young Ha, Huisuk Yang, Geonwoo Kang, Hai Yen Thi Nguyen, Yuri Kim, Myung-Sik Choi, Nam-Hyuk Cho, Hyungil Jung
Dissolving microneedles (DMNs) have been widely studied in medical applications due to their pain-free administration, superior efficiency, and safe drug delivery. In skin vaccination, preserving the activity of the encapsulated antigen is an important consideration, as antigen activity is lost during DMN fabrication because of various stress factors. These stress factors vary between fabrication methods and each method affects the antigen's activity to different degrees. In this study, the activity of encapsulated antigens delivered by DMNs is compared between two recently developed DMN fabrication methods; droplet-born air blowing (DAB) and centrifugal lithography (CL) for a model scrub typhus vaccine antigen, ScaA...
April 16, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29663691/an-evaluation-of-the-antiaging-properties-of-strawberry-hydrolysate-treatment-enriched-with-l-ascorbic-acid-applied-with-microneedle-mesotherapy
#5
Agata Markiewicz, Malwina Zasada, Anna Erkiert-Polguj, Marzena Wieckowska-Szakiel, Elzbieta Budzisz
BACKGROUND: Mature skin is characterized by a loss of elasticity, hyperpigmentation, and dehydration. L-ascorbic acid stimulates the synthesis of collagen type I, inhibits melanogenesis, and helps to maintain correct skin hydration. Combining microneedle mesotherapy with the application of preparations rich in vitamin C results in better therapeutic effects due to the improved absorption of active substances. The study evaluates the effectiveness of the application of strawberry hydrolysate enriched with L-ascorbic acid using microneedle mesotherapy...
April 16, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29652837/fabrication-of-composite-microneedle-array-electrode-for-temperature-and-bio-signal-monitoring
#6
Yiwei Sun, Lei Ren, Lelun Jiang, Yong Tang, Bin Liu
Body temperature and bio-signals are important health indicators that reflect the human health condition. However, monitoring these indexes is inconvenient and time-consuming, requires various instruments, and needs professional skill. In this study, a composite microneedle array electrode (CMAE) was designed and fabricated. It simultaneously detects body temperature and bio-signals. The CMAE consists of a 6 × 6 microneedles array with a height of 500 μm and a base diameter of 200 μm. Multiple insertion experiments indicate that the CMAE possesses excellent mechanical properties...
April 13, 2018: Sensors
https://www.readbyqxmd.com/read/29652835/fabrication-of-flexible-microneedle-array-electrodes-for-wearable-bio-signal-recording
#7
Lei Ren, Shujia Xu, Jie Gao, Zi Lin, Zhipeng Chen, Bin Liu, Liang Liang, Lelun Jiang
Laser-direct writing (LDW) and magneto-rheological drawing lithography (MRDL) have been proposed for the fabrication of a flexible microneedle array electrode (MAE) for wearable bio-signal monitoring. Conductive patterns were directly written onto the flexible polyethylene terephthalate (PET) substrate by LDW. The microneedle array was rapidly drawn and formed from the droplets of curable magnetorheological fluid with the assistance of an external magnetic field by MRDL. A flexible MAE can maintain a stable contact interface with curved human skin due to the flexibility of the PET substrate...
April 13, 2018: Sensors
https://www.readbyqxmd.com/read/29627889/nonenzymatic-determination-of-glucose-at-near-neutral-ph-values-based-on-the-use-of-nafion-and-platinum-black-coated-microneedle-electrode-array
#8
Somasekhar R Chinnadayyala, Ilhwan Park, Sungbo Cho
The authors report on a microneedle-based amperometric nonenzymatic glucose sensor for painless and continuous monitoring of glucose. It consists of 3 × 5 sharp stainless steel microneedles micromachined from a stainless steel substrate. The microneedles are 600 and 100 μm in height and width, respectively. Nafion and platinum black were sequentially coated onto the tip of gold-coated microneedles and used for nonenzymatic (direct) sensing of glucose. Attractive features of the modified microneedle electrode include (a) a low working potential (+0...
April 7, 2018: Mikrochimica Acta
https://www.readbyqxmd.com/read/29621751/skin-barrier-restoration-and-moisturization-using-horse-oil-loaded-dissolving-microneedle-patches
#9
Chisong Lee, Younghyon Andrew Eom, Huisuk Yang, Mingyu Jang, Sang Uk Jung, Ye Oak Park, Si Eun Lee, Hyungil Jung
BACKGROUND: Horse oil (HO) has skin barrier restoration and skin-moisturizing effects. Although cream formulations have been used widely and safely, their limited penetration through the stratum corneum is a major obstacle to maximizing the cosmetic efficacy of HO. Therefore, we aimed to encapsulate HO in a cosmetic dissolving microneedle (DMN) for efficient transdermal delivery. METHODS: To overcome these limitations of skin permeation, HO-loaded DMN (HO-DMN) patches were developed and evaluated for their efficacy and safety using in vitro and clinical studies...
April 5, 2018: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/29616489/zein-microneedles-for-localized-delivery-of-chemotherapeutic-agents-to-treat-breast-cancer-drug-loading-release-behavior-and-skin-permeation-studies
#10
Shubhmita Bhatnagar, Pooja Kumari, Srijanaki Paravastu Pattarabhiran, Venkata Vamsi Krishna Venuganti
Localized delivery of chemotherapeutic agents to treat breast cancer could limit their adverse drug reactions. The aim of this study was to investigate the influence of physico-chemical properties of chemotherapeutic agents in their loading, release behavior, and skin permeation using microneedles. Zein microneedles were fabricated using the micromolding technique containing 36 microneedles in a 1-cm2 area. These microneedles were loaded with two anti-breast cancer drugs, tamoxifen and gemcitabine, having different water solubilities...
April 3, 2018: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29608119/peri-tumor-administration-of-5-fluorouracil-sol-gel-using-a-hollow-microneedle-for-treatment-of-gastric-cancer
#11
Yoon Suk Jung, Dong-Hoe Koo, Jeong-Yoon Yang, Hee-Young Lee, Jung-Hwan Park, Jung Ho Park
The aim of this study was to investigate the effectiveness of treating gastric cancer by injecting a pluronic F-127 sol-gel formulation of 5-fluorouracil (5-FU) into normal tissue surrounding the tumor using a hollow microneedle. The MTS tetrazolium assay was performed to assess the cytotoxicity of 5-FU after application to gastric cancer cells at different concentrations for 1, 5 and 10 h. Gastric cancer cells were inoculated subcutaneously into 30 male nude mice (CrjBALB/c-nu/nu mice, male); the inoculated mouse were divided into three groups...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29607442/admittance-control-for-robot-assisted-retinal-vein-micro-cannulation-under-human-robot-collaborative-mode
#12
He Zhang, Berk Gonenc, Iulian Iordachita
Retinal vein occlusion is one of the most common retinovascular diseases. Retinal vein cannulation is a potentially effective treatment method for this condition that currently lies, however, at the limits of human capabilities. In this work, the aim is to use robotic systems and advanced instrumentation to alleviate these challenges, and assist the procedure via a human-robot collaborative mode based on our earlier work on the Steady-Hand Eye Robot and force-sensing instruments. An admittance control method is employed to stabilize the cannula relative to the vein and maintain it inside the lumen during the injection process...
October 2017: ICCAS ...: International Conference on Control, Automation, and Systems
https://www.readbyqxmd.com/read/29604374/insulin-delivery-systems-combined-with-microneedle-technology
#13
Xuan Jin, Dan Dan Zhu, Bo Zhi Chen, Mohammad Ashfaq, Xin Dong Guo
Diabetes, a metabolic disorder of glucose, is a serious chronic disease and an important public health problem. Insulin is one of the hormones for modulating blood glucose level and the products of which is indispensable for most diabetes patients. Introducing microneedles (MNs) to insulin delivery is promising to pave the way for modulating glucose level noninvasively of diabetes patients, as which born to be painless, easy to handle and no need of any power supply. In this work, we review the process of insulin delivery systems (IDSs) based on MN technology in terms of two categories: drug free MNs and drug loaded MNs...
March 28, 2018: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29601621/prospective-randomized-investigator-blinded-split-face-evaluation-of-a-topical-crosslinked-hyaluronic-acid-serum-for-post-procedural-improvement-of-skin-quality-and-biomechanical-attributes
#14
Hema Sundaram, Angnieszka Cegielska, Agnieszka Wojciechowska, Patrice Delobel
BACKGROUND: This split-face, controlled study investigated the ability of a topical crosslinked hyaluronic acid formulation (RHA serum) to enhance clinical results from fillers, microneedling, or chemical peeling of aging skin. Previous comparative skin explant studies demonstrated greater efficacy of RHA serum than topical non-crosslinked high or low molecular weight hyaluronic acid in decreasing trans-epidermal water loss, increasing epidermal hydration, and improving corneocyte microstructure...
April 1, 2018: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29595852/composite-dissolving-microneedle-patches-for-chemotherapy-and-photothermal-therapy-in-superficial-tumor-treatment
#15
Peng Pei, Fan Yang, Jiaxing Liu, Haoran Hu, Xiaoyu Du, Nobutaka Hanagata, Shichang Zhao, Yufang Zhu
A combination of chemotherapy and photothermal therapy (PTT) has emerged as a promising strategy for cancer therapy. To ensure that the chemotherapeutic drug and photothermal agent can be simultaneously delivered to the tumor site to exert their synergistic effects, a safe and efficient delivery system is needed. Herein, we fabricated doxorubicin hydrochloride (DOX)- and indocyanine green (ICG)-loaded microneedle (MN) patches (PVP@DOX/MSN@ICG) using a two-step casting process. Mesoporous silica nanoparticles (MSNs) were used to improve the ICG stability and avoid reducing its PTT efficiency in vivo...
March 29, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29595229/cell-delivery-using-microneedle-devices-a-new-approach-to-treat-depigmenting-disorders
#16
K Boniface, A Taieb, J Seneschal
No abstract text is available yet for this article.
March 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29574973/adenosine-loaded-dissolving-microneedle-patches-to-improve-skin-wrinkles-dermal-density-elasticity-and-hydration
#17
G Kang, T N T Tu, S Kim, H Yang, M Jang, D Jo, J Rye, J Baek, H Jung
OBJECTIVE: Although dissolving microneedle patches have been widely studied in the cosmetics field, no comparisons have been drawn with the topical applications available for routine use. In this study, two wrinkle-improving products, adenosine-loaded dissolving microneedle patches and an adenosine cream, were evaluated for efficacy, with respect to skin wrinkling, dermal density, elasticity, and hydration, and safety in a clinical test on the crow's feet area. METHODS: Clinical efficacy and safety tests were performed for 10 weeks on 22 female subjects with wrinkles around their eyes...
March 25, 2018: International Journal of Cosmetic Science
https://www.readbyqxmd.com/read/29555437/3d-printed-microneedles-for-insulin-skin-delivery
#18
Cristiane Patricia Pissinato Pere, Sophia N Economidou, Gurprit Lall, Clémentine Ziraud, Joshua S Boateng, Bruce D Alexander, Dimitrios A Lamprou, Dennis Douroumis
In this study, polymeric microneedle patches were fabricated by stereolithography, a 3D printing technique, for the transdermal delivery of insulin. A biocompatible resin was photopolymerized to build pyramid and cone microneedle designs followed by inkjet print coating of insulin formulations., trehalose and xylitol were used as drug carriers with the aim to preserve insulin integrity and stability but also facilitate rapid release rates. Circular dichroism and Raman analysis demonstrated that all carriers maintained the native form of insulin with xylitol presenting the best performance...
March 16, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29554482/transcutaneous-implantation-of-valproic-acid-encapsulated-dissolving-microneedles-induces-hair-regrowth
#19
Shayan Fakhraei Lahiji, Seol Hwa Seo, Suyong Kim, Manita Dangol, Jiyong Shim, Cheng Guo Li, Yonghao Ma, Chisong Lee, Geonwoo Kang, Huisuk Yang, Kang-Yell Choi, Hyungil Jung
The interest in alternative material systems and delivery methods for treatment of androgenetic alopecia has been increasing in the recent decades. Topical application of valproic acid (VPA), an FDA-approved anticonvulsant drug, has been shown to effectively stimulate hair follicle (HF) regrowth by upregulating Wnt/β-catenin, a key pathway involved in initiation of HF development. Moreover, a majority of studies have suggested that cutaneous wound re-epithelialization is capable of inducing HF through Wnt/β-catenin pathway...
June 2018: Biomaterials
https://www.readbyqxmd.com/read/29543377/skin-microneedling-for-acne-scars-associated-with-pigmentation-in-patients-with-dark-skin
#20
Firas Al Qarqaz, Ali Al-Yousef
BACKGROUND: Acne is very common skin condition. Most patients with acne will have a degree of scarring as a result of their acne. In patients with darker skin color the scarring can be further complicated by hyperpigmentation. Several treatment options can be used to improve acne scarring, however the problem of post acne hyperpigmentation is not often addressed. This study especially focus on the treatment of pigmented post acne scarring using skin microneedling. AIMS: The primary objective is to assess the improvement of pigmentation of acne scarring in patients with dark skin using microneedling...
March 15, 2018: Journal of Cosmetic Dermatology
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