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https://www.readbyqxmd.com/read/29032329/successful-transdermal-allergen-delivery-and-allergen-specific-immunotherapy-using-biodegradable-microneedle-patches
#1
Ji Hye Kim, Jung U Shin, Seo Hyeong Kim, Ji Yeon Noh, Hye Ran Kim, Jungsoo Lee, Howard Chu, Kyoung Yong Jeong, Kyung Hee Park, Jung Dong Kim, Hong Kee Kim, Do Hyeon Jeong, Tai-Soon Yong, Jung-Won Park, Kwang Hoon Lee
Allergen-specific immunotherapy (SIT) is an effective treatment modality for allergic diseases such as atopic dermatitis (AD). However, frequent visits over a 3-year period as well as looming adverse events tend to discourage patient compliance. Therefore, a more convenient, effective, and safe method of SIT is needed. For several decades, use of microneedles has been promoted as an efficient and precise transdermal drug delivery method. In this study, we developed Dermatophagoides farinae (D. farinae) extract (DfE)-loaded microneedle patches, and evaluated their safety and efficacy as a novel SIT method...
October 4, 2017: Biomaterials
https://www.readbyqxmd.com/read/29030224/transfer-molded-wrappable-microneedle-meshes-for-perivascular-drug-delivery
#2
JiYong Lee, Dae Hyun Kim, Kang Ju Lee, Il Ho Seo, Seung Hyun Park, Eui Hwa Jang, Youngjoo Park, Young-Nam Youn, WonHyoung Ryu
After surgical procedures such as coronary/peripheral bypass grafting or endarterectomy for the treatment of organ ischemia derived from atherosclerosis, intimal hyperplasia (IH) which leads to restenosis or occlusion at the site of graft anastomosis frequently occurs. In order to inhibit IH caused by abnormal growth of smooth muscle cells (SMCs) in tunica media, various perivascular drug delivery devices are reported for delivery of anti-proliferation drugs into vascular tissue. However, there still remain conflicting requirements such as local and unidirectional delivery vs device porosity, and conformal tight device installation vs pulsatile expansion and constriction of blood vessels...
October 10, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29028863/the-future-of-non-invasive-rejuvenation-technology-devices
#3
Michael H Gold
<p>Non-invasive rejuvenation of the skin is performed regularly in many cosmetic offices. Using evidence-based medicine, we will review the various technologies being used for non-invasive rejuvenation. This includes the use of intense pulsed light (IPL), which has been thoroughly studied and shown to be quite useful for this type of rejuvenation in removing the red and brown pigments, as well as affecting collagen. Fractional lasers, both non-ablative and ablative in nature, also can show dramatic improvements in the skin and associated clinical studies are reviewed here...
June 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29028377/randomized-trial-of-electrodynamic-microneedle-combined-with-5-minoxidil-topical-solution-for-the-treatment-of-chinese-male-androgenetic-alopecia
#4
Linlin Bao, Lin Gong, Menger Guo, Taoming Liu, Anyu Shi, Haifeng Zong, Xuegang Xu, Hongduo Chen, Xinghua Gao, Yuanhong Li
BACKGROUND: In treating androgenetic alopecia, 5% minoxidil is a commonly used topical drug. By using electrodynamic microneedle at the same time may increase absorption of minoxidil and further stimulate hair growth. OBJECTIVE: A 24-week, randomized, evaluator blinded, comparative study was performed to evaluate the efficacy of treating Chinese male androgenetic alopecia using microneedle combined with 5% minoxidil topical solution. METHODS: Randomized subjects received topical 5% minoxidil (group 1, n = 20), local electrodynamic microneedle treatments (group 2, n = 20), or local electrodynamic microneedle treatments plus topical 5% minoxidil (group 3, n = 20)...
October 13, 2017: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/29025223/unusual-presentation-of-tinea-corporis-associated-with-the-use-of-a-microneedling-device
#5
Nélia Margarida Martins da Cunha, Sara Leite de Azevedo Campos, Ana Isabel Pina Clemente Fidalgo
No abstract text is available yet for this article.
July 1, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29019915/revolutionizing-therapeutic-drug-monitoring-with-the-use-of-interstitial-fluid-and-microneedles-technology
#6
REVIEW
Tony K L Kiang, Sahan A Ranamukhaarachchi, Mary H H Ensom
While therapeutic drug monitoring (TDM) that uses blood as the biological matrix is the traditional gold standard, this practice may be impossible, impractical, or unethical for some patient populations (e.g., elderly, pediatric, anemic) and those with fragile veins. In the context of finding an alternative biological matrix for TDM, this manuscript will provide a qualitative review on: (1) the principles of TDM; (2) alternative matrices for TDM; (3) current evidence supporting the use of interstitial fluid (ISF) for TDM in clinical models; (4) the use of microneedle technologies, which is potentially minimally invasive and pain-free, for the collection of ISF; and (5) future directions...
October 11, 2017: Pharmaceutics
https://www.readbyqxmd.com/read/28987023/efficacy-and-safety-of-a-novel-soluble-microneedle-patch-for-the-improvement-of-facial-wrinkle
#7
Ji Yeon Hong, Eun Jung Ko, Sun Young Choi, Kapsok Li, A Reum Kim, Jin O Park, Beom Joon Kim
BACKGROUND: Various kinds of functional cosmetics are on the market, although there are a variety of opinions concerning the actual effect. Transdermal microneedle patch has been introduced as a newly developed device for drug delivery through the skin. OBJECTIVE: This study was conducted to verify the face skin improvement effect and safety of a novel cosmetic microneedle patch. METHODS: A total of 84 Korean females finished this prospective clinical trial...
October 7, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28983850/topical-administration-of-ibuprofen-for-injured-athletes-considerations-formulations-and-comparison-to-oral-delivery
#8
REVIEW
Martin Anthony Christopher Manoukian, Christopher William Migdal, Amode Ravindra Tembhekar, Jerad Alexander Harris, Charles DeMesa
Non-steroidal anti-inflammatory drugs (NSAIDs) are a class of drugs commonly used to treat both the acute and chronic injuries sustained by athletes during training and competition. In many parts of the world, NSAIDs can be purchased over-the-counter and used without any physician oversight. However, the chronic nature of overuse injuries requires NSAIDs to be taken orally for an extended period of time. As a result, they can have significant adverse effects on athletes, namely gastrointestinal (GI), renal, and cardiovascular damage...
October 5, 2017: Sports Medicine—Open
https://www.readbyqxmd.com/read/28964902/skin-vaccination-using-microneedles-coated-with-a-plasmid-dna-cocktail-encoding-nucleosomal-histones-of-leishmania-spp
#9
Esther Moreno, Juana Schwartz, Alba Calvo, Laura Blanco, Esther Larrea, Juan M Irache, Carmen Sanmartín, Sion A Coulman, Manuel Soto, James C Birchall, Socorro Espuelas
Vaccine delivery using microneedles (MNs) represents a safe, easily disposable and painless alternative to traditional needle immunizations. The MN delivery of DNA vaccines to the dermis may result in a superior immune response and/or an equivalent immune response at a lower vaccine dose (dose-sparing). This could be of special interest for immunization programs against neglected tropical diseases such as leishmaniasis. In this work, we loaded a MN device with 60μg of a plasmid DNA cocktail encoding the Leishmania infantum nucleosomal histones H2A, H2B, H3 and H4 and compared its immunogenicity and protective capacity against conventional s...
September 28, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28960218/3d-shape-evolution-of-microparticles-and-3d-enabled-applications-using-non-uniform-uv-flow-lithography-nufl
#10
Kenneth Choi, Mohammad Salehizadeh, Rafael Belo Da Silva, Navid Hakimi, Eric Diller, Dae Kun Hwang
The generation of microparticles with non-spherical morphologies has generated extensive interest because of their enhanced physical properties that can increase their performance in a wide variety of clinical and industrial applications. A flow lithographic technique based on stop flow lithography (SFL) recently showed the ability to fabricate particles with 3D shapes via manipulation of the UV intensity profile in a simple 2D microfluidic channel. Here, we further explore this flow lithographic method, called non-uniform flow lithography (NUFL), to investigate the 3D-shape tuning ability for the generation of 3D magnetic microparticles and their potential applications...
September 29, 2017: Soft Matter
https://www.readbyqxmd.com/read/28955031/printing-of-small-molecular-medicines-from-the-vapor-phase
#11
Olga Shalev, Shreya Raghavan, J Maxwell Mazzara, Nancy Senabulya, Patrick D Sinko, Elyse Fleck, Christopher Rockwell, Nicholas Simopoulos, Christina M Jones, Anna Schwendeman, Geeta Mehta, Roy Clarke, Gregory E Amidon, Max Shtein
There is growing need to develop efficient methods for early-stage drug discovery, continuous manufacturing of drug delivery vehicles, and ultra-precise dosing of high potency drugs. Here we demonstrate the use of solvent-free organic vapor jet printing to deposit nanostructured films of small molecular pharmaceutical ingredients, including caffeine, paracetamol, ibuprofen, tamoxifen, BAY 11-7082 and fluorescein, with accuracy on the scale of micrograms per square centimeter, onto glass, Tegaderm, Listerine tabs, and stainless steel microneedles...
September 27, 2017: Nature Communications
https://www.readbyqxmd.com/read/28946634/towards-robot-assisted-retinal-vein-cannulation-a-motorized-force-sensing-microneedle-integrated-with-a-handheld-micromanipulator-%C3%A2
#12
Berk Gonenc, Jeremy Chae, Peter Gehlbach, Russell H Taylor, Iulian Iordachita
Retinal vein cannulation is a technically demanding surgical procedure where therapeutic agents are injected into the retinal veins to treat occlusions. The clinical feasibility of this approach has been largely limited by the technical challenges associated with performing the procedure. Among the challenges to successful vein cannulation are identifying the moment of venous puncture, achieving cannulation of the micro-vessel, and maintaining cannulation throughout drug delivery. Recent advances in medical robotics and sensing of tool-tissue interaction forces have the potential to address each of these challenges as well as to prevent tissue trauma, minimize complications, diminish surgeon effort, and ultimately promote successful retinal vein cannulation...
September 23, 2017: Sensors
https://www.readbyqxmd.com/read/28944738/an-industry-update-the-latest-developments-in-therapeutic-delivery
#13
Oliver C Steinbach
The present industry update covers the period 1-30 June 2017, with information sourced from company press releases, regulatory and patent agencies as well as scientific literature. The combination of drug and devices such as improved, safer injectables (see various market reports, companies Adamis and Baxter), patches (Microdermis) and (nano)carriers are moving increasingly from the R&D stage into clinical trials and toward the market. This addresses increased safety and effectiveness requirements, limiting physico-chemical properties of active ingredients, cost-effectiveness and patient comfort through ease of use...
October 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28943194/intradermal-vaccination-with-hollow-microneedles-a-comparative-study-of-various-protein-antigen-and-adjuvant-encapsulated-nanoparticles
#14
Guangsheng Du, Rania M Hathout, Maha Nasr, M Reza Nejadnik, Jing Tu, Roman I Koning, Abraham J Koster, Bram Slütter, Alexander Kros, Wim Jiskoot, Joke A Bouwstra, Juha Mönkäre
In this study, we investigated the potential of intradermal delivery of nanoparticulate vaccines to modulate the immune response of protein antigen using hollow microneedles. Four types of nanoparticles covering a broad range of physiochemical parameters, namely poly (lactic-co-glycolic) (PLGA) nanoparticles, liposomes, mesoporous silica nanoparticles (MSNs) and gelatin nanoparticles (GNPs) were compared. The developed nanoparticles were loaded with a model antigen (ovalbumin (OVA)) with and without an adjuvant (poly(I:C)), followed by the characterization of size, zeta potential, morphology, and loading and release of antigen and adjuvant...
September 21, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28940666/successful-treatment-of-trichoepithelioma-with-a-novel-insulated-monopolar-radiofrequency-microneedle-device
#15
J Y Hong, J Seok, J M Kim, Y J Jang, B J Kim
No abstract text is available yet for this article.
September 20, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28935595/plasma-treatment-as-an-efficient-tool-for-controlled-drug-release-from-polymeric-materials-a-review
#16
REVIEW
D G Petlin, S I Tverdokhlebov, Y G Anissimov
One of the most actively developing fields in modern medicine is controlled drug delivery, an ability to keep optimal concentration of a drug at the desired body location. In particular, the most attention for potential use as drug delivery vehicles is drawn towards biodegradable polymeric materials. This is due to the versatility of tools for their fabrication, as well as due to the need to extract them after implantation being eliminated. In order to enhance polymer characteristics in terms of biocompatibility their surface can be functionalized...
September 19, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28929244/analyzing-polymeric-matrix-for-fabrication-of-a-biodegradable-microneedle-array-to-enhance-transdermal-delivery
#17
Kuo-Yuan Hwa, Vincent H S Chang, Yao-Yi Cheng, Yue-Da Wang, Pey-Shynan Jan, Boopathi Subramani, Min-Ju Wu, Bo-Kai Wang
Traditional drug delivery systems, using invasive, transdermal, and oral routes, are limited by various factors, such as the digestive system environment, skin protection, and sensory nerve stimulation. To improve the drug delivery system, we fabricated a polysaccharide-based, dissolvable microneedle-based array, which combines the advantages of both invasive and transdermal delivery systems, and promises to be an innovative solution for minimally invasive drug delivery. In this study, we designed a reusable aluminum mold that greatly improved the efficiency and convenience of microneedle fabrication...
September 19, 2017: Biomedical Microdevices
https://www.readbyqxmd.com/read/28919324/pretreatment-of-skin-using-an-abrasive-skin-preparation-pad-a-microneedling-device-or-iontophoresis-improves-absorption-of-methyl-aminolevulinate-in-ex-vivo-human-skin
#18
Hanan Osman-Ponchet, Alexandre Gaborit, Karine Sevin, Christophe Bianchi, Jean-Michel Linget, Claire E Wilson, Guy Bouvier
BACKGROUND: Pretreatment of skin to remove scales/crusts and roughen the surface is essential to enhance the penetration of topically applied methyl aminolevulinate (MAL) prior to photodynamic therapy and to permit daylight to access all parts of the skin lesions. Numerous procedures of skin preparation are currently available. This study compared the in vitro penetration of MAL into ex vivo human skin pretreated with skin preparation pad abrasion or a microneedling device, and evaluated the effectiveness of an iontophoretic device in delivering MAL into ex vivo human skin...
September 12, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28919029/recent-advances-of-controlled-drug-delivery-using-microfluidic-platforms
#19
REVIEW
Sharma T Sanjay, Wan Zhou, Maowei Dou, Hamed Tavakoli, Lei Ma, Feng Xu, XiuJun Li
Conventional systematically-administered drugs distribute evenly throughout the body, get degraded and excreted rapidly while crossing many biological barriers, leaving minimum amounts of the drugs at pathological sites. Controlled drug delivery aims to deliver drugs to the target sites at desired rates and time, thus enhancing the drug efficacy, pharmacokinetics, and bioavailability while maintaining minimal side effects. Due to a number of unique advantages of the recent microfluidic lab-on-a-chip technology, microfluidic lab-on-a-chip has provided unprecedented opportunities for controlled drug delivery...
September 15, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28917531/hollow-microneedle-mediated-intradermal-delivery-of-model-vaccine-antigen-loaded-plga-nanoparticles-elicits-protective-t-cell-mediated-immunity-to-an-intracellular-bacterium
#20
Anne Marit de Groot, Guangsheng Du, Juha Mönkäre, Anouk C M Platteel, Femke Broere, Joke A Bouwstra, Alice J A M Sijts
The skin is an attractive organ for immunization due to the presence of a large number of epidermal and dermal antigen-presenting cells. Hollow microneedles allow for precise and non-invasive intradermal delivery of vaccines. In this study, ovalbumin (OVA)-loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles with and without TLR3 agonist poly(I:C) were prepared and administered intradermally by hollow microneedles. The capacity of the PLGA nanoparticles to induce a cytotoxic T cell response, contributing to protection against intracellular pathogens, was examined...
September 14, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
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