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Moetaz El-Domyati, Hossam Abdel-Wahab, Aliaa Hossam
BACKGROUND: Minimally invasive procedures provide effective, safe, relatively long-lasting, and natural results without large damage to the skin. A combination treatment is considered an approach that includes at least 2 different and unrelated modalities. OBJECTIVES: This study aims to evaluate the use and effectiveness of some combined minimally invasive procedures for management of acne scarring. PATIENTS/METHODS: Twenty-four volunteers with postacne atrophic scars were randomly divided into 3 equal groups according to performed procedure on each side of the face (microneedling by dermaroller alone or combined with platelet-rich plasma [PRP] or trichloroacetic acid [TCA] 15% peeling) and received 6 bi-weekly sessions of treatment...
December 10, 2017: Journal of Cosmetic Dermatology
Sara Hogan, Mara Weinstein Velez, Omer Ibrahim
Microneedling is a minimally invasive procedure wherein small holes are created across the stratum corneum while keeping the epidermis partially intact. This produces microchannels that increase skin permeability and simultaneously stimulate growth factor release. Since the epidermis is retained, microneedling has less risk of infection, postinflammatory hyperpigmentation, and scarring compared to other resurfacing modalities. This is a review of the literature on microneedling in the treatment of textural abnormalities, specifically rhytides, scars, and striae...
December 2017: Seminars in Cutaneous Medicine and Surgery
Dong-Jin Lim, Jeremy B Vines, Hansoo Park, Soo-Hong Lee
Human skin is made up of multiple layers and is designed to protect the human body. The stratum corneum (SC), specifically, is a keratinized layer of skin through which molecules heavier than 500Da cannot penetrate. Traditional methods of transdermal drug delivery through the SC, such as hypodermic needles, are less than ideal because their size and appearance can cause fear and pain, creating hesitation, limiting self-administration, and preventing their use in some patients altogether. A new technology has been developed to address these limitations, in which an array of needles, each microns in diameter and length, called microneedles, are able to pierce the skin's SC to deliver therapeutic agents without stimulating the proprioceptive pain nerves...
December 6, 2017: International Journal of Biological Macromolecules
Jianmin Chen, Weiyue Huang, Ziyao Huang, Shiqi Liu, Yaling Ye, Qinglian Li, Meiping Huang
Dissolving microneedles (MNs) offered a simple, minimally invasive method for meloxicam (MX) delivery to the skin. However, the fabrication of dissolving MNs still faced some challenges, such as significant time consumption, loss of drug activity, and difficulty in regulating MN drug loading. To address these issues, we developed the tip-dissolving (TD) MNs. Several kinds of drugs were encapsulated successfully, and the quantity of MX ranged from 37.23 ± 8.40 to 332.53 ± 13.37 μg was precisely controlled...
December 7, 2017: AAPS PharmSciTech
Guozhong Yang, Meilin He, Suohui Zhang, Man Wu, Yunhua Gao
Swellable microneedles (SMNs) are made of hydrogels and can deliver drug with controlled delivery rate by the cross-link density of the hydrogel. In this study, an acryl resin-based SMNs was developed for poorly water-soluble drugs. The making process of the SMNs is very simple and only need 60 min. The SMNs has high mechanical strength and is not easily broken. In-vitro release of SMNs-loaded model drug, granisetron base (GRB), was investigated. The results showed that 7 days controlled release of GRB was obtained when SMNs contained pore-foaming agents (1...
December 8, 2017: Drug Development and Industrial Pharmacy
Nadine G Rouphael, Mark J Mulligan
No abstract text is available yet for this article.
November 7, 2017: Oncotarget
T M Rawson, D O'Hare, P Herrero, S Sharma, L S P Moore, E de Barra, J A Roberts, A C Gordon, W Hope, P Georgiou, A E G Cass, A H Holmes
Sub-optimal exposure to antimicrobial therapy is associated with poor patient outcomes and the development of antimicrobial resistance. Mechanisms for optimizing the concentration of a drug within the individual patient are under development. However, several barriers remain in realizing true individualization of therapy. These include problems with plasma drug sampling, availability of appropriate assays, and current mechanisms for dose adjustment. Biosensor technology offers a means of providing real-time monitoring of antimicrobials in a minimally invasive fashion...
December 4, 2017: Journal of Antimicrobial Chemotherapy
Sung-Min An, Keum-Yong Seong, Sang-Gu Yim, Young Jun Hwang, Seong Hwan Bae, Seung Yun Yang, Beum-Soo An
Due to growing interest in cosmetics and medical applications, therapeutic medications that reduce the amount of local subcutaneous adipose tissue have potential for obesity treatment. However, conventional methods such as surgical operation are restricted due to risk of complications. Here, we report a simple and effective method for local reduction of subcutaneous adipose tissue (AT) by using microneedle-assisted transdermal delivery of natural polymers. After in vitro screening tests, gelatin was selected as a therapeutic polymer to reduce accumulation of AT...
December 2, 2017: Acta Biomaterialia
Qi Lei Wang, Xiao Peng Zhang, Bo Zhi Chen, Xin Dong Guo
Microneedle (MN) systems for painless transdermal drug delivery have been developed in the past few years to overcome the issues of hypodermic injections. This study introduces a novel dissolvable layered microneedle (LMN) with core-shell structure for efficient transdermal drug delivery. Fabricated by three-step-casting method, the LMNs encapsulated the drug into the HA layer as a "shell", which is supported by PVA layer as core and base. When the LMNs are inserted into the skin, the drug would be released immediately once the HA layer were separated or dissolved...
February 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
Rachel R Hartman, Uday B Kompella
Even though the very thought of an injection into the eye may be frightening, an estimated 6 million intravitreal (IVT) injections were made in the USA during 2016. With the introduction of new therapeutic agents, this number is expected to increase. In addition, drug products that are injectable in ocular compartments other than the vitreous humor are expected to enter the back of the eye market in the not so distant future. Besides the IVT route, some of the most actively investigated routes of invasive administration to the eye include periocular, subretinal, and suprachoroidal (SC) routes...
December 5, 2017: Journal of Ocular Pharmacology and Therapeutics
Ha Ryeong Ryu, Hye-Rin Jeong, Hye-Seung Seon-Woo, Jung Soo Kim, Seul Ki Lee, Hee Joo Kim, Jin Ok Baek, Jung-Hwan Park, Joo Young Roh
Warts are a common skin disease caused by infection of the human papilloma virus. Most treatments involving physical destruction of the infected cells, such as cryotherapy and electrocautery, are limited by intense pain, failure, or recurrences. Our aim was to compare the therapeutic effects of a newly developed bleomycin microneedle patch with cryotherapy in the treatment of warts. Forty-two patients with more than two wart lesions were included in the study. The two treatment modalities were randomly applied to different warts on each patient...
December 4, 2017: Drug Delivery and Translational Research
Alexey S Rzhevskiy, Thakur Raghu Raj Singh, Ryan F Donnelly, Yuri G Anissimov
Microneedles is the technique of drug delivery enhancement, which was primarily designed for facilitating percutaneous drug delivery. Started from the development of simple solid microneedles, providing microporation of stratum corneum and therefore enhancement of topical drug delivery, for two decades the technique has progressed in various modifications such as hollow, coated, dissolving and hydrogel forming microneedles. In their turn, the modifications have resulted in new mechanisms of drug delivery enhancement and followed by the expansion of applicability range in terms of targeted tissues and organs...
December 1, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
P Ronnander, L Simon, H Spilgies, A Koch, S Scherr
In-vitro permeation studies were conducted to assess the feasibility of fabricating dissolving-microneedle-array systems to release sumatriptan succinate. The formulations consisted mainly of the encapsulated active ingredient and a water-soluble biologically compatible polymer, polyvinylpyrrolidone (PVP), approved by the U.S. Food and Drug Administration (FDA). Tests with Franz-type diffusion cells and Göttingen minipig skins showed an increase of the transdermal flux compared to passive diffusion. A preparation, containing 30% by mass of PVP and 8...
December 1, 2017: European Journal of Pharmaceutical Sciences
Raymond M Fertig, A Caresse Gamret, Jessica Cervantes, Antonella Tosti
Microneedling is a minimally invasive dermatological procedure in which fine needles are rolled over the skin to puncture the stratum corneum. This therapy is used to induce collagen formation, neovascularization, and growth factor production of treated areas. It has been used in a wide range of dermatologic conditions, including androgenetic alopecia and alopecia areata, among others. While there are a limited number of studies examining this therapy in the use of hair loss, microneedling has been successfully paired with other hair growth promoting therapies, such as minoxidil, platelet rich plasma, and topical steroids, and shown to stimulate hair follicle growth...
December 1, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
John C Morrison, Elaine C Johnson, William O Cepurna
A reliable method of creating chronic elevation of intraocular pressure (IOP) in rodents is an important tool in reproducing and studying the mechanisms of optic nerve injury that occur in glaucoma. In addition, such a model could provide a valuable method for testing potential neuroprotective treatments. This paper outlines the basic methods for producing obstruction of aqueous humor outflow and IOP elevation by injecting hypertonic saline (a sclerosant) into the aqueous outflow pathway. This is one of several rodent glaucoma models in use today...
2018: Methods in Molecular Biology
Ming-Yang Chen, Yi-Ying Chen, Hsin-Tzu Tsai, Tzong-Shin Tzai, Mei-Chin Chen, Yuh-Shyan Tsai
Long-term administration of luteinizing hormone-releasing hormone analogs (LHRHa) is the main type of androgen-deprivation therapy (ADT) for lethal prostate cancer. A fully insertable microneedle system, composed of embeddable chitosan microneedles and a dissolvable polyvinyl alcohol/polyvinyl pyrrolidone supporting array, was developed for sustained delivery of LHRHa to the skin. A porcine cadaver skin test showed that chitosan microneedles can be fully embedded within the skin and microneedle-created micropores reseal within 7 days...
December 2017: Anticancer Research
Emerson V A Lima, Mariana Modesto D A Lima, Mauricio Pedreira Paixão, Hélio Amante Miot
BACKGROUND: Melasma is a common chronic and relapsing acquired dyschromia. Skin microneedling was reported resulting sustained long-term improvement of recalcitrant melasma, however, the exact mechanism that promotes this skin lightening is not known. This study aimed to investigate clinical and histologic alterations promoted by skin microneedling in facial melasma. METHODS: Open pilot trial including six women with facial refractory melasma submitted to two sessions of microneedling (1...
November 28, 2017: BMC Dermatology
Hyunji Lee, Jung-Hwan Park, Jung Ho Park
PURPOSE: A low temperature hollow microneedle system was devised to deliver sol-gel transition formulation near the surface of the skin for extended release and local delivery of drug by a non-invasive method. This new system can improve treatment of intermittent fecal incontinence. METHOD: The low-temperature system was integrated with a hollow microneedle to maintain the low temperature of the sol formulation. Various sol-gel formulations using Pluronic F-127 (PF-127) and Hydroxy-propyl-methyl-cellulose (HPMC) were prepared, and their gelation temperature, flow property, and diffusion retardation were observed...
November 27, 2017: Pharmaceutical Research
Wei Chen, Rui Tian, Can Xu, Bryant C Yung, Guohao Wang, Yijing Liu, Qianqian Ni, Fuwu Zhang, Zijian Zhou, Jingjing Wang, Gang Niu, Ying Ma, Liwu Fu, Xiaoyuan Chen
The delivery of therapeutic peptides for diabetes therapy is compromised by short half-lives of drugs with the consequent need for multiple daily injections that reduce patient compliance and increase treatment cost. In this study, we demonstrate a smart exendin-4 (Ex4) delivery device based on microneedle (MN)-array patches integrated with dual mineralized particles separately containing Ex4 and glucose oxidase (GOx). The dual mineralized particle-based system can specifically release Ex4 while immobilizing GOx as a result of the differential response to the microenvironment induced by biological stimuli...
November 24, 2017: Nature Communications
Meilin He, Guozhong Yang, Suohui Zhang, Xiaoyu Zhao, Yunhua Gao
This study presents a design that lipophilic drug was encapsulated within dissolving microneedles (DMNs) for sustained-release delivery over one week. Etonogestrel (ENG), the progestogen used in hormonal contraceptives, was loaded in two-layered DMNs in form of microcrystal particles (MP). In vitro release study indicated that ENG in form of MP could sustain drug release compared to non-crystal form. Hydroxypropyl methylcellulose (HPMC) and polyvinyl alcohol (PVA) was used to prepare the fast dissolving needle-tips and flexible back layer, respectively...
November 23, 2017: Journal of Pharmaceutical Sciences
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