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Hoda Zarkoob, Sathivel Chinnathambi, John C Selby, Edward A Sander
Cell migration is an essential part of many (patho)physiological processes, including keratinocyte re-epithelialization of healing wounds. Physical forces and mechanical cues from the wound bed (in addition to biochemical signals) may also play an important role in the healing process. Previously, we explored this possibility and found that polyacrylamide (PA) gel stiffness affected human keratinocyte behaviour and that mechanical deformations in soft (approx. 1.2 kPa) PA gels produced by neighbouring cells appeared to influence the process of de novo epithelial sheet formation...
June 2018: Journal of the Royal Society, Interface
Cassie L Caudill, Jillian L Perry, Shaomin Tian, J Christopher Luft, Joseph M DeSimone
Microneedle patches, arrays of micron-scale projections that penetrate skin in a minimally invasive manner, are a promising tool for transdermally delivering therapeutic proteins. However, current microneedle fabrication techniques are limited in their ability to fabricate microneedles rapidly and with a high degree of control over microneedle design parameters. We have previously demonstrated the ability to fabricate microneedle patches with a range of compositions and geometries using the novel additive manufacturing technique Continuous Liquid Interface Production (CLIP)...
June 9, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
Ying Liu, Ling Ye, Fang Lin, Yasmine Gomaa, David Flyer, Ricardo Carrion, Jean L Patterson, Mark R Prausnitz, Gale Smith, Gregory Glenn, Hua Wu, Richard W Compans, Chinglai Yang
In this study, we investigated immune responses induced by purified Ebola virus (EBOV) soluble glycoprotein (sGP) subunit vaccines via intradermal immunization with microneedle (MN) patches in comparison with intramuscular (IM) injection in mice. Our results showed that MN delivery of EBOV sGP was superior to IM injection in eliciting higher levels and longer lasting antibody responses against EBOV sGP and GP antigens. Moreover, sGP-specific immune responses induced by MN or IM immunizations were effectively augmented by formulating sGP with a saponin-based adjuvant, and they were shown to confer complete protection of mice against lethal mouse-adapted EBOV (MA-EBOV) challenge...
June 8, 2018: Journal of Infectious Diseases
Hayley Leatham, Linna Guan, Anne Lynn S Chang
No abstract text is available yet for this article.
July 2018: JAAD Case Reports
Aaron McConville, Catherine Hegarty, James Davis
The increasing devolution of healthcare towards community care has meant that the management of many conditions is conducted within the home either by community nurses or by the patients themselves. The administration of medicines within home healthcare scenarios can however be problematic—especially when considering the delivery of medicines through injection. The possibility of needlestick injury (NSI) has become an ever-present hazard within healthcare settings, with a significant proportion of percutaneous injuries occurring during the handling and disposal of the needle...
June 8, 2018: Medicines (Basel, Switzerland)
Abhijeet Kumar Jha, Sidharth Sonthalia, Deepak Jakhar
No abstract text is available yet for this article.
June 8, 2018: Journal of the American Academy of Dermatology
Jolanda Richter-Johnson, Pradeep Kumar, Yahya E Choonara, Lisa C du Toit, Viness Pillay
Microneedle (MN) arrays contain a backing plate with multiple microscopic projections to puncture the skin and can be used to deliver drug in a minimally invasive way. Advantages of MNs are numerous including administration of large molecules, avoiding first-pass metabolism, ease of administration, lack of pain, site-specific drug targeting, and dose reduction due to increased absorption efficacy. The growth in the transdermal market has been fueled by an increasing number of chronic disease patients and a demand for easy and pain-free drug administration...
June 14, 2018: Expert Review of Pharmacoeconomics & Outcomes Research
Aykut Aksit, Daniel N Arteaga, Miguel Arriaga, Xun Wang, Hirobumi Watanabe, Karen E Kasza, Anil K Lalwani, Jeffrey W Kysar
The cochlea, or inner ear, is a space fully enclosed within the temporal bone of the skull, except for two membrane-covered portals connecting it to the middle ear space. One of these portals is the round window, which is covered by the Round Window Membrane (RWM). A longstanding clinical goal is to reliably and precisely deliver therapeutics into the cochlea to treat a plethora of auditory and vestibular disorders. Standard of care for several difficult-to-treat diseases calls for injection of a therapeutic substance through the tympanic membrane into the middle ear space, after which a portion of the substance diffuses across the RWM into the cochlea...
June 8, 2018: Biomedical Microdevices
Qian Zhang, Chuncao Xu, Shiqi Lin, Huanbin Zhou, Gangtao Yao, Hu Liu, Lili Wang, Xin Pan, Guilan Quan, Chuanbin Wu
Dissolving microneedles carried drug molecules can effectively penetrate the stratum corneum of skin to improve the transdermal drug delivery. The traditional Chinese medicine acupuncture is based on the needle stimulation at a specific location (acupoint) to generate and transmit biochemical and physiological signals which alter the pathophysiological state of patients. However, the pain associated with conventional acupuncture needles and the requirement of highly trained professionals limit the development of acupuncture in non-Asian countries...
May 2018: Acta Pharmaceutica Sinica. B
Dean Nicholas, Keiran A Logan, Yingjie Sheng, Jinhui Gao, Sian Farrell, Dorian Dixon, Bridgeen Callan, Anthony P McHale, John F Callan
The monitoring of blood glucose is a key aspect of diabetes care in limiting the negative effects of hyperglycaemia to both the microvasculature and macrovasculature. Self-monitoring of blood glucose (SMBG) gives an indication of blood glucose at a specific point in time and is recommended to be carried out four times daily. However, due to the inconvenience and associated pain of blood withdrawal, SMBG is often carried out less frequently than recommended or not at all. Extraction and subsequent determination of glucose in interstitial fluid (ISF) using microneedles (MNs) is an emerging area of research due to their minimally invasive nature and lack of associated pain...
June 4, 2018: International Journal of Pharmaceutics
Guangsheng Du, Mara Leone, Stefan Romeijn, Gideon Kersten, Wim Jiskoot, Joke A Bouwstra
In this study, we aimed to investigate the immunogenicity of cationic liposomes loaded with diphtheria toxoid (DT) and poly(I:C) after hollow microneedle-mediated intradermal vaccination in mice. The following liposomal formulations were studied: DT loaded liposomes, a mixture of free DT and poly(I:C)-loaded liposomes, a mixture of DT-loaded liposomes and free poly(I:C), and liposomal formulations with DT and poly(I:C) either individually or co-encapsulated in the liposomes. Reference groups were DT solution adjuvanted with or without poly(I:C) (DT/poly(I:C))...
June 2, 2018: International Journal of Pharmaceutics
Min Jung Kim, Seok Chan Park, Binod Rizal, Giselle Guanes, Seung-Ki Baek, Jung-Hwan Park, Amy R Betz, Seong-O Choi
In this study we present the fabrication of multilayer microneedles with circular obelisk and beveled-circular obelisk geometries, which have potential applications in implantable drug delivery devices. Micro-milling was adopted as an environmental-friendly and cost-effective way to fabricate primary metal microneedle masters. Polylactic acid (PLA) microneedles with sharp tips were then obtained by micromolding followed by oxygen plasma etching and used for preparing polydimethylsiloxane (PDMS) microneedle molds...
2018: Frontiers in Bioengineering and Biotechnology
Iman M N Hamdan, Ismaiel A Tekko, Kyle B Matchett, Luis G Arnaut, Claudia S Silva, Helen O McCarthy, Ryan F Donnelly
Nodular basal cell carcinoma is a deep skin lesion and one of the most common cancers. Conventional photodynamic therapy (PDT) is limited to treatment of superficial skin lesions. The parenteral administration of near infrared (NIR) preformed photosensitisers suffers from poor selectivity and may result in prolonged skin photosensitivity. Microneedles (MN) can provide localised drug delivery to skin lesions. Intradermal delivery of the preformed NIR photosensitiser; 5,10,15,20-tetrakis(2,6-difluoro-3-N-methylsulfamoylphenyl bacteriochlorin (Redaporfin™™) using dissolving MN was successful in vitro and in vivo...
June 1, 2018: Journal of Pharmaceutical Sciences
Sattar Kabiri, Mohsen Pourazizi, Bahareh Abtahi-Naeini
No abstract text is available yet for this article.
2018: Advanced Biomedical Research
Sonia Golombek, Martin Pilz, Heidrun Steinle, Efrat Kochba, Yotam Levin, Dominique Lunter, Christian Schlensak, Hans Peter Wendel, Meltem Avci-Adali
In recent years, synthetic mRNA-based applications to produce desired exogenous proteins in cells have been gaining importance. However, systemic delivery of synthetic mRNA can result in unspecific uptake into undesired cells or organs and, thereby, fail to target desired cells. Thus, local and targeted delivery of synthetic mRNA becomes increasingly important to reach the desired cell types and tissues. In this study, intradermal delivery of synthetic mRNA using a hollow microneedle injection-based method was evaluated...
June 1, 2018: Molecular Therapy. Nucleic Acids
Francesco Dal Dosso, Tadej Kokalj, Jaroslav Belotserkovsky, Dragana Spasic, Jeroen Lammertyn
In this work, we present a new iSIMPLE concept (infusion Self-powered Imbibing Microfluidic Pump by Liquid Encapsulation), which requires no external power for activation nor liquid manipulation, it is easy to use while its fabrication method is extremely simple, inexpensive and suited for mass replication. The pump consists of a working liquid, which is - after finger activation - absorbed in a porous material (e.g. filter paper). The air expelled from the porous material increases the pressure in the downstream outlet channel and propels the outlet liquid (i...
May 31, 2018: Biomedical Microdevices
Guojun Chen, Jicheng Yu, Zhen Gu
Antidiabetic therapeutics, including insulin as well as glucagon-like peptide 1 (GLP-1) and its analogs, are essential for people with diabetes to regulate their blood glucose levels. Nevertheless, conventional treatments based on hypodermic administration is commonly associated with poor blood glucose control, a lack of patient compliance, and a high risk of hypoglycemia. Closed-loop drug delivery strategies, also known as self-regulated administration, which can intelligently govern the drug release kinetics in response to the fluctuation in blood glucose levels, show tremendous promise in diabetes therapy...
May 1, 2018: Journal of Diabetes Science and Technology
Noha H Moftah, Mohammad A M El Khayyat, Maha H Ragai, Heba Alaa
BACKGROUND: Acne scarring has been a challenge to treat. Microneedling gained popularity in treatment of such scars. Meanwhile, carboxytherapy (CXT) is considered a novel treatment modality for acne scars. OBJECTIVE: To evaluate efficacy of CXT versus microneedling in treatment of acne scars. METHODS AND MATERIALS: Thirty-two patients with atrophic acne scars received 6 sessions of microneedling and CXT on right and left sides of face, respectively...
May 24, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
Meng Chan He, Bo Zhi Chen, Mohammad Ashfaq, Xin Dong Guo
The rapidly separating microneedles (RS-PP-MNs), composed of PVA (separable arrow head) MNs and a poly(L-lactide-co-D, L-lactide) (PLA) supporting array, are used for transdermal delivery system at high humidity. The fabricated RS-PP-MNs should have sufficient mechanical strength at different humidity. In general, the water adsorption rate was increased with increasing humidity; by contrast, storage time was decreased with increasing humidity. The higher water adsorption rate indicated the lower mechanical strength, thereby lowering drug delivery efficiency...
May 29, 2018: Drug Delivery and Translational Research
Juha Mönkäre, Maria Pontier, Eveline E M van Kampen, Guangsheng Du, Mara Leone, Stefan Romeijn, M Reza Nejadnik, Conor O'Mahony, Bram Slütter, Wim Jiskoot, Joke A Bouwstra
Skin is an attractive but also very challenging immunisation site for particulate subunit vaccines. The aim of this study was to develop hyaluronan (HA)-based dissolving microneedles (MNs) loaded with PLGA nanoparticles (NPs) co-encapsulating ovalbumin (OVA) and poly(I:C) for intradermal immunisation. The NP:HA ratio used for the preparation of dissolving MNs appeared to be critical for the quality of MNs and their dissolution in ex vivo human skin. Asymmetrical flow field-flow fractionation and dynamic light scattering were used to analyse the NPs released from the MNs in vitro...
May 24, 2018: European Journal of Pharmaceutics and Biopharmaceutics
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