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David Haines

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https://www.readbyqxmd.com/read/29452408/genome-wide-association-study-identifies-seven-novel-susceptibility-loci-for-primary-open-angle-glaucoma
#1
Yukihiro Shiga, Masato Akiyama, Koji M Nishiguchi, Kota Sato, Nobuhiro Shimozawa, Atsushi Takahashi, Yukihide Momozawa, Makoto Hirata, Matsuda Koichi, Taiki Yamaji, Motoki Iwasaki, Shoichiro Tsugane, Isao Oze, Haruo Mikami, Mariko Naito, Kenji Wakai, Munemitsu Yoshikawa, Masahiro Miyake, Kenji Yamashiro, Kenji Kashiwagi, Takeshi Iwata, Fumihiko Mabuchi, Mitsuko Takamoto, Mineo Ozaki, Kazuhide Kawase, Makoto Aihara, Makoto Araie, Tetsuya Yamamoto, Yoshiaki Kiuchi, Makoto Nakamura, Yasuhiro Ikeda, Koh-Hei Sonoda, Tatsuro Ishibashi, Koji Nitta, Aiko Iwase, Shiroaki Shirato, Yoshitaka Oka, Mamoru Satoh, Makoto Sasaki, Nobuo Fuse, Yoichi Suzuki, Ching-Yu Cheng, Chiea Chuen Khor, Mani Baskaran, Shamira Perera, Tin Aung, Eranga N Vithana, Jessica N Cooke Bailey, Jae H Kang, Louis R Pasquale, Jonathan L Haines, Janey L Wiggs, Kathryn P Burdon, Puya Gharahkhani, Alex W Hewitt, David A Mackey, Stuart MacGregor, Jamie E Craig, R Rand Allingham, Micheal Hauser, Adeyinka Ashaye, Donald L Budenz, Stephan Akafo, Susan E I Williams, Yoichiro Kamatani, Toru Nakazawa, Michiaki Kubo
Primary open-angle glaucoma (POAG) is the leading cause of irreversible blindness worldwide for which 15 disease-associated loci had been discovered. Among them, only 5 loci have been associated with POAG in Asians. We carried out a genome-wide association study and a replication study that included a total of 7,378 POAG cases and 36,385 controls from a Japanese population. After combining the GWAS and the two replication sets, we identified 11 POAG-associated loci, including 4 known (CDKN2B-AS1, ABCA1, SIX6 and AFAP1) and 7 novel loci (FNDC3B, ANKRD55-MAP3K1, LMX1B, LHPP, HMGA2, MEIS2 and LOXL1) at a genome-wide significance level (p < 5...
February 14, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29449654/analysis-combining-correlated-glaucoma-traits-identifies-five-new-risk-loci-for-open-angle-glaucoma
#2
Puya Gharahkhani, Kathryn P Burdon, Jessica N Cooke Bailey, Alex W Hewitt, Matthew H Law, Louis R Pasquale, Jae H Kang, Jonathan L Haines, Emmanuelle Souzeau, Tiger Zhou, Owen M Siggs, John Landers, Mona Awadalla, Shiwani Sharma, Richard A Mills, Bronwyn Ridge, David Lynn, Robert Casson, Stuart L Graham, Ivan Goldberg, Andrew White, Paul R Healey, John Grigg, Mitchell Lawlor, Paul Mitchell, Jonathan Ruddle, Michael Coote, Mark Walland, Stephen Best, Andrea Vincent, Jesse Gale, Graham RadfordSmith, David C Whiteman, Grant W Montgomery, Nicholas G Martin, David A Mackey, Janey L Wiggs, Stuart MacGregor, Jamie E Craig
Open-angle glaucoma (OAG) is a major cause of blindness worldwide. To identify new risk loci for OAG, we performed a genome-wide association study in 3,071 OAG cases and 6,750 unscreened controls, and meta-analysed the results with GWAS data for intraocular pressure (IOP) and optic disc parameters (the overall meta-analysis sample size varying between 32,000 to 48,000 participants), which are glaucoma-related traits. We identified and independently validated four novel genome-wide significant associations within or near MYOF and CYP26A1, LINC02052 and CRYGS, LMX1B, and LMO7 using single variant tests, one additional locus (C9) using gene-based tests, and two genetic pathways - "response to fluid shear stress" and "abnormal retina morphology" - in pathway-based tests...
February 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29428155/statin-medications-are-associated-with-decreased-risk-of-sepsis-and-anastomotic-leaks-after-rectal-resections
#3
David Disbrow, Corie L Seelbach, Jeremy Albright, Jane Ferraro, Juan Wu, Jon M Hain, Beth-Ann Shanker, Robert K Cleary
BACKGROUND: This study was designed to determine the effect of statins on colorectal postoperative complications related to sepsis. Previous studies have reported conflicting results. METHODS: This is a retrospective propensity score analysis of postoperative outcomes from a large regional database of patients who underwent elective colorectal resection from June 2012-July 2015. RESULTS: 7285 patients met inclusion criteria: 34.5% received statins...
January 31, 2018: American Journal of Surgery
https://www.readbyqxmd.com/read/29395240/using-epistemic-network-analysis-to-identify-targets-for-educational-interventions-in-trauma-team-communication
#4
Sarah Sullivan, Charles Warner-Hillard, Brendan Eagan, Ryan J Thompson, A R Ruis, Krista Haines, Carla M Pugh, David Williamson Shaffer, Hee Soo Jung
BACKGROUND: Epistemic Network Analysis (ENA) is a technique for modeling and comparing the structure of connections between elements in coded data. We hypothesized that connections among team discourse elements as modeled by ENA would predict the quality of team performance in trauma simulation. METHODS: The Modified Non-technical Skills Scale for Trauma (T-NOTECHS) was used to score a simulation-based trauma team resuscitation. Sixteen teams of 5 trainees participated...
February 1, 2018: Surgery
https://www.readbyqxmd.com/read/29392307/testosterone-pathway-genetic-polymorphisms-in-relation-to-primary-open-angle-glaucoma-an-analysis-in-two-large-datasets
#5
Jessica N Cooke Bailey, Puya Gharahkhani, Jae H Kang, Mariusz Butkiewicz, David A Sullivan, Robert N Weinreb, Hugues Aschard, R Rand Allingham, Allison Ashley-Koch, Richard K Lee, Sayoko E Moroi, Murray H Brilliant, Gadi Wollstein, Joel S Schuman, John H Fingert, Donald L Budenz, Tony Realini, Terry Gaasterland, William K Scott, Kuldev Singh, Arthur J Sit, Robert P Igo, Yeunjoo E Song, Lisa Hark, Robert Ritch, Douglas J Rhee, Douglas Vollrath, Donald J Zack, Felipe Medeiros, Thasarat S Vajaranant, Daniel I Chasman, William G Christen, Margaret A Pericak-Vance, Yutao Liu, Peter Kraft, Julia E Richards, Bernard A Rosner, Michael A Hauser, Jamie E Craig, Kathryn P Burdon, Alex W Hewitt, David A Mackey, Jonathan L Haines, Stuart MacGregor, Janey L Wiggs, Louis R Pasquale
Purpose: Sex hormones may be associated with primary open-angle glaucoma (POAG), although the mechanisms are unclear. We previously observed that gene variants involved with estrogen metabolism were collectively associated with POAG in women but not men; here we assessed gene variants related to testosterone metabolism collectively and POAG risk. Methods: We used two datasets: one from the United States (3853 cases and 33,480 controls) and another from Australia (1155 cases and 1992 controls)...
February 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29388435/guelph-family-health-study-s-home-based-obesity-prevention-intervention-increases-fibre-and-fruit-intake-in-preschool-aged-children
#6
Julia A Mirotta, Gerarda A Darlington, Andrea C Buchholz, Jess Haines, David W L Ma, Alison M Duncan
PURPOSE: The Guelph Family Health Study (GFHS) pilot was designed to examine the feasibility and effectiveness of a home-based obesity prevention intervention on health behaviours and obesity risk. The objective of this analysis was to determine the effect of the 6-month intervention on preschool-aged children's dietary intakes. METHODS: Families with children aged 1.5-5 years old were randomized to receive one of the following: 4 home visits with a health educator as well as tailored emails and mailed incentives (4HV; n = 19 children); 2 home visits with a health educator as well as tailored emails and mailed incentives (2HV; n = 14 children); or general health advice through emails (control; n = 12 children)...
February 1, 2018: Canadian Journal of Dietetic Practice and Research
https://www.readbyqxmd.com/read/29385734/single-nucleotide-polymorphisms-in-taste-receptor-genes-are-associated-with-snacking-patterns-of-preschool-aged-children-in-the-guelph-family-health-study-a-pilot-study
#7
Elie Chamoun, Joy M Hutchinson, Owen Krystia, Julia A Mirotta, David M Mutch, Andrea C Buchholz, Alison M Duncan, Gerarda Darlington, Jess Haines, David W L Ma
Snacking is an integral component of eating habits in young children that is often overlooked in nutrition research. While snacking is a substantial source of calories in preschoolers' diets, there is limited knowledge about the factors that drive snacking patterns. The genetics of taste may help to better understand the snacking patterns of children. The rs1761667 single nucleotide polymorphism (SNP) in the CD36 gene has been linked to fat taste sensitivity, the rs35874116 SNP in the TAS1R2 gene has been related to sweet taste preference, and the rs713598 SNP in the TAS2R38 gene has been associated with aversion to bitter, green leafy vegetables...
January 30, 2018: Nutrients
https://www.readbyqxmd.com/read/29376702/surfactant-variations-in-porous-media-localize-capillary-instabilities-during-haines-jumps
#8
Yaniv Edery, Steffen Berg, David Weitz
We use confocal microscopy to measure velocity and interfacial tension between a trapped wetting phase with a surfactant and a flowing, invading nonwetting phase in a porous medium. We relate interfacial tension variations at the fluid-fluid interface to surfactant concentration and show that these variations localize the destabilization of capillary forces and lead to rapid local invasion of the nonwetting fluid, resulting in a Haines jump. These spatial variations in surfactant concentration are caused by velocity variations at the fluid-fluid interfaces and lead to localization of the Haines jumps even in otherwise very uniform pore structure and pressure conditions...
January 12, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29354880/endothelin-1-induced-hypertrophic-alterations-and-heme-oxygenase-1-expression-in-cardiomyoblasts-are-counteracted-by-beta-estradiol-in-vitro-and-in-vivo-studies
#9
Tunde Barta, Agnes Tosaki, David Haines, Gyorgy Balla, Istvan Lekli, Arpad Tosaki
Endothelin-1 (ET-1), a potent vasoconstrictor normally active in maintaining vascular tone, may mediate significant pathogenic effects, contributing to several serious diseases when aberrantly expressed or regulated. The present study evaluates the capacity of ET-1 to affect endothelin-1-associated hypertrophic activity and decreased expression of heme oxygenase-1 by H9c2 rat cardiomyoblasts in vitro, corresponding to in vivo processes underlying cardiovascular diseases (CVDs). Beta estradiol (β-E) is tested for its capacity to alter the effects of ET-1...
January 21, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29242236/near-field-ultrasound-imaging-during-radiofrequency-catheter-ablation-tissue-thickness-and-epicardial-wall-visualization-and-assessment-of-radiofrequency-ablation-lesion-formation-and-depth
#10
David E Haines, Matthew Wright, Erik Harks, Szabolcs Deladi, Steven Fokkenrood, Rob Brink, Harm Belt, Alexander F Kolen, Nenad Mihajlovic, Fei Zuo, Darrell Rankin, William Stoffregen, Debra Cockayne, Joseph Cefalu
BACKGROUND: Safe and successful radiofrequency catheter ablation depends on creation of transmural lesions without collateral injury to contiguous structures. Near-field ultrasound (NFUS) imaging through transducers in the tip of an ablation catheter may provide important information about catheter contact, wall thickness, and ablation lesion formation. METHODS AND RESULTS: NFUS imaging was performed using a specially designed open-irrigated radiofrequency ablation catheter incorporating 4 ultrasound transducers...
December 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29236685/origin-and-differentiation-of-human-memory-cd8-t-cells-after-vaccination
#11
Rama S Akondy, Mark Fitch, Srilatha Edupuganti, Shu Yang, Haydn T Kissick, Kelvin W Li, Ben A Youngblood, Hossam A Abdelsamed, Donald J McGuire, Kristen W Cohen, Gabriela Alexe, Shashi Nagar, Megan M McCausland, Satish Gupta, Pramila Tata, W Nicholas Haining, M Juliana McElrath, David Zhang, Bin Hu, William J Greenleaf, Jorg J Goronzy, Mark J Mulligan, Marc Hellerstein, Rafi Ahmed
The differentiation of human memory CD8 T cells is not well understood. Here we address this issue using the live yellow fever virus (YFV) vaccine, which induces long-term immunity in humans. We used in vivo deuterium labelling to mark CD8 T cells that proliferated in response to the virus and then assessed cellular turnover and longevity by quantifying deuterium dilution kinetics in YFV-specific CD8 T cells using mass spectrometry. This longitudinal analysis showed that the memory pool originates from CD8 T cells that divided extensively during the first two weeks after infection and is maintained by quiescent cells that divide less than once every year (doubling time of over 450 days)...
December 13, 2017: Nature
https://www.readbyqxmd.com/read/29192589/figure-of-eight-suture-for-venous-hemostasis-in-fully-anticoagulated-patients-after-atrial-fibrillation-catheter-ablation
#12
Umashankar Lakshmanadoss, Wai Shun Wong, Ilana Kutinsky, M Rizwan Khalid, Brian Williamson, David E Haines
INTRODUCTION: Limited data exists for types of venous closure and its associated complications in patients after atrial fibrillation (AF) catheter ablation. We evaluated the subcutaneous figure-of-eight closure (FO8) for achieving venous hemostasis after AF catheter ablation compared to manual pressure. METHODS: 284 consecutive patients that underwent AF catheter ablation by two operators were included. All patients received continuous therapeutic warfarin or interrupted novel oral anticoagulants (NOAC) and heparin (ACT300-400 s) without reversal...
September 2017: Indian Pacing and Electrophysiology Journal
https://www.readbyqxmd.com/read/29186589/detergent-insoluble-proteins-and-inclusion-body-like-structures-immunoreactive-for-prkdc-dna-pk-dna-pkcs-ftl-nnt-and-aifm1-in-the-amygdala-of-cognitively-impaired-elderly-persons
#13
Jozsef Gal, Jing Chen, Yuriko Katsumata, David W Fardo, Wang-Xia Wang, Sergey Artiushin, Douglas Price, Sonya Anderson, Ela Patel, Haining Zhu, Peter T Nelson
Misfolded protein in the amygdala is a neuropathologic feature of Alzheimer disease and many other neurodegenerative disorders. We examined extracts from human amygdala (snap-frozen at autopsy) to investigate whether novel and as yet uncharacterized misfolded proteins would be detectable. Polypeptides from the detergent-insoluble, urea-soluble protein fractions of amygdala were interrogated using liquid chromatography-electrospray ionization-tandem mass spectrometry. Among the detergent-insoluble proteins identified in amygdala of demented subjects but not controls were Tau, TDP-43, Aβ, α-synuclein, and ApoE...
November 24, 2017: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/29153980/why-saying-what-you-mean-matters-an-analysis-of-trauma-team-communication
#14
Hee Soo Jung, Charles Warner-Hillard, Ryan Thompson, Krista Haines, Brooke Moungey, Anne LeGare, David Williamson Shaffer, Carla Pugh, Suresh Agarwal, Sarah Sullivan
BACKGROUND: We hypothesized that team communication with unmatched grammatical form and communicative intent (mixed mode communication) would correlate with worse trauma teamwork. METHODS: Interdisciplinary trauma simulations were conducted. Team performance was rated using the TEAM tool. Team communication was coded for grammatical form and communicative intent. The rate of mixed mode communication (MMC) was calculated. MMC rates were compared to overall TEAM scores...
November 8, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/29142969/elucidation-of-renal-scars-in-children-with%C3%A2-vesicoureteral-reflux-using-contrast-enhanced-ultrasound-a-pilot%C3%A2-study
#15
David S Hains, Harris L Cohen, M Beth McCarville, Ellen E Ellison, Amy Huffman, Stacey Glass, Aslam H Qureshi, Keith R Pierce, Ashlyn L Cahill, Ashley Dixon, Noel Delos Santos
Introduction: Vesicoureteral reflux is a common disorder in children but can result in kidney scarring following acute pyelonephritis. The gold standard diagnostic to detect renal scars in children is (99m)Tc-dimercaptosuccinic acid (DMSA) scintigraphy. DMSA has a number of limitations including radiation exposure, need for sedation, and radiotracer supply shortages. Contrast-enhanced ultrasound (CEUS) is a technique whereby biocompatible microspheres of inert gas are administered i.v...
May 2017: KI Reports
https://www.readbyqxmd.com/read/29111544/atrioesophageal-fistula-following-radiofrequency-catheter-ablation-of-atrial-fibrillation
#16
Molly Orosey, Lohit Garg, Sahil Agrawal, Jinu J John, David E Haines, Wai Shun Wong
Atrioesophageal fistula (AEF) is a rare but catastrophic complication of catheter ablation of atrial fibrillation (AF), with an incidence of 0.03% to 1.5% per year. We report two cases and review the epidemiology, clinical features, pathogenesis, and management of AEF after AF ablation. The principal clinical features of AEF include fever, hematemesis, and neurologic deficits within 2 months after ablation. The close proximity of the esophagus to the posterior left atrial wall is considered responsible for esophageal injury during ablation and the eventual development of AEF...
2017: Reviews in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29101163/cdk4-6-inhibition-augments-antitumor-immunity-by-enhancing-t-cell-activation
#17
Jiehui Deng, Eric S Wang, Russell W Jenkins, Shuai Li, Ruben Dries, Kathleen Yates, Sandeep Chhabra, Wei Huang, Hongye Liu, Amir R Aref, Elena Ivanova, Cloud P Paweletz, Michaela Bowden, Chensheng W Zhou, Grit S Herter-Sprie, Jessica A Sorrentino, John E Bisi, Patrick H Lizotte, Ashley A Merlino, Max M Quinn, Lauren E Bufe, Annan Yang, Yanxi Zhang, Hua Zhang, Peng Gao, Ting Chen, Megan E Cavanaugh, Amanda J Rode, Eric Haines, Patrick J Roberts, Jay C Strum, William G Richards, Jochen H Lorch, Sareh Parangi, Viswanath Gunda, Genevieve M Boland, Raphael Bueno, Sangeetha Palakurthi, Gordon J Freeman, Jerome Ritz, W Nicholas Haining, Norman E Sharpless, Haribabu Arthanari, Geoffrey I Shapiro, David A Barbie, Nathanael S Gray, Kwok-Kin Wong
Immune checkpoint blockade, exemplified by antibodies targeting the PD-1 receptor, can induce durable tumor regressions in some patients. To enhance the efficacy of existing immunotherapies, we screened for small molecules capable of increasing the activity of T cells suppressed by PD-1. Here, we show that short-term exposure to small-molecule inhibitors of cyclin-dependent kinases 4 and 6 (CDK4/6) significantly enhances T-cell activation, contributing to antitumor effects in vivo, due in part to the derepression of NFAT family proteins and their target genes, critical regulators of T-cell function...
November 3, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/29098650/cancer-survivorship-care-plan-utilization-and-impact-on-clinical-decision-making-at-point-of-care-visits-with-primary-care-results-from-an-engineering-primary-care-and-oncology-collaborative-for-survivorship-health
#18
SarahMaria Donohue, James E Haine, Zhanhai Li, David A Feldstein, Mark Micek, Elizabeth R Trowbridge, Sandra A Kamnetz, James M Sosman, Lee G Wilke, Mary E Sesto, Amye J Tevaarwerk
Every cancer survivor and his/her primary care provider should receive an individualized survivorship care plan (SCP) following curative treatment. Little is known regarding point-of-care utilization at primary care visits. We assessed SCP utilization in the clinical context of primary care visits. Primary care physicians and advanced practice providers (APPs) who had seen survivors following provision of an SCP were identified. Eligible primary care physicians and APPs were sent an online survey, evaluating SCP utilization and influence on decision-making at the point-of-care, accompanied by copies of the survivor's SCP and the clinic note...
November 2, 2017: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/29096948/the-lancet-countdown-on-health-and-climate-change-from-25-years-of-inaction-to-a-global-transformation-for-public-health
#19
REVIEW
Nick Watts, Markus Amann, Sonja Ayeb-Karlsson, Kristine Belesova, Timothy Bouley, Maxwell Boykoff, Peter Byass, Wenjia Cai, Diarmid Campbell-Lendrum, Jonathan Chambers, Peter M Cox, Meaghan Daly, Niheer Dasandi, Michael Davies, Michael Depledge, Anneliese Depoux, Paula Dominguez-Salas, Paul Drummond, Paul Ekins, Antoine Flahault, Howard Frumkin, Lucien Georgeson, Mostafa Ghanei, Delia Grace, Hilary Graham, Rébecca Grojsman, Andy Haines, Ian Hamilton, Stella Hartinger, Anne Johnson, Ilan Kelman, Gregor Kiesewetter, Dominic Kniveton, Lu Liang, Melissa Lott, Robert Lowe, Georgina Mace, Maquins Odhiambo Sewe, Mark Maslin, Slava Mikhaylov, James Milner, Ali Mohammad Latifi, Maziar Moradi-Lakeh, Karyn Morrissey, Kris Murray, Tara Neville, Maria Nilsson, Tadj Oreszczyn, Fereidoon Owfi, David Pencheon, Steve Pye, Mahnaz Rabbaniha, Elizabeth Robinson, Joacim Rocklöv, Stefanie Schütte, Joy Shumake-Guillemot, Rebecca Steinbach, Meisam Tabatabaei, Nicola Wheeler, Paul Wilkinson, Peng Gong, Hugh Montgomery, Anthony Costello
No abstract text is available yet for this article.
October 30, 2017: Lancet
https://www.readbyqxmd.com/read/29073466/targeted-photodynamic-therapy-of-breast-cancer-cells-using-lactose-phthalocyanine-functionalized-gold-nanoparticles
#20
Paula García Calavia, Isabelle Chambrier, Michael J Cook, Alan H Haines, Robert A Field, David A Russell
Gold nanoparticles (AuNPs), which have been widely used for the delivery of photosensitizers for photodynamic therapy (PDT) of cancer, can be dispersed in aqueous solutions improving the delivery of the hydrophobic photosensitizer into the body. Furthermore, the large surface of AuNPs can be functionalized with a variety of ligands, including proteins, nucleic acids and carbohydrates, that allow selective targeting to cancer tissue. In this study, gold nanoparticles were functionalized with a mixed monolayer of a zinc phthalocyanine and a lactose derivative...
October 10, 2017: Journal of Colloid and Interface Science
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