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Kuan-Pin Chen, Cheng-Chia Lee, Chia-Lin Liao, Tao-Chieh Yang, Tsung-Lang Chiu, Chain-Fa Su
In this report, we present the results of using upfront gamma knife surgery (GKS) in the management of giant central neurocytoma (volume > 50 ml) without the initial removal of the tumor mass. Two patients underwent GKS for histologically proven central neurocytoma (CNC). Clinical and imaging studies were performed to evaluate the response to treatment. GKS involved delivery doses of 12 or 13 Gy to the tumor margin at the isodose line of 50%. Tumor response to GKS appeared as early as 4-6 months post-GKS, at which point a dramatic reduction in volume was observed...
October 21, 2016: World Neurosurgery
Aruna Nambirajan, Mehar C Sharma, Madhu Rajeshwari, Aanchal Kakkar, Vaishali Suri, Chitra Sarkar
Ependymomas are gliomas that recapitulate normal ependymal cells. The epithelial membrane antigen (EMA) shows "dot-like" and "ring-like" staining patterns, highlighting "microlumens" or intracytoplasmic rosettes, a pathognomonic ultrastructural feature. NHERF1/EBP50, an adaptor protein localized at the apical plasma membrane of human epithelia, has been found to localize to these microlumens. We aimed to analyze the staining patterns of EMA and EBP50 in ependymomas and other tumors, and thereby compare their diagnostic utility...
October 7, 2016: Applied Immunohistochemistry & Molecular Morphology: AIMM
Madhivanan Karthigeyan, Kirti Gupta, Pravin Salunke
Central neurocytomas are well-differentiated tumors of neuronal origin. These are relatively uncommon in the pediatric population. Anaplastic features reflected by brisk mitotic activity, microvascular proliferation, necrosis, and MIB-1 labeling index >2% or 3% have been proposed to indicate aggressive behavior. Because of its rarity, there is paucity of data regarding the histologic spectrum and outcome of central neurocytomas in children. With this short series, we describe our observations of the clinicopathologic characteristics and outcome of this tumor in children over a 5-year period...
September 23, 2016: Journal of Child Neurology
Tadanori Tomita, Jerome M Volk, Wenjun Shen, Tatiana Pundy
OBJECT: Glioneuronal tumors are common neoplasms among the cerebral hemisphere during childhood. They consist of several histological types, of which gangliogliomas (GGs) and dysembryoplastic neuroepithelial tumors (DNTs) are most common and often present with seizures. A great majority of glioneuronal tumors are benign. However, there are conflict reports regarding postoperative tumor recurrence rates and seizure control. The authors analyzed and compared these tumors for their locations and histology and the tumor and seizure control following resection...
October 2016: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
Daniel Rusiecki, Boleslaw Lach, Branavan Manoranjan, Adam Fleming, Olufemi Ajani, Sheila K Singh
We report a childhood case of thalamic atypical extraventricular neurocytoma that progressed to highly anaplastic ganglioglioma (GG) after eight years of dormancy following subtotal resection and chemotherapy. The neurocytoma displayed immunoreactivity only for synaptophysin, beta-catenin, S-100 and CD56. The GG acquired strong immunoreactivity for chromogranin, glial fibrillary acidic protein, neuron specific enolase and p53 and showed a very high proliferation rate approaching 50% in some areas. Tumor transformation was associated with overexpression of components of the sonic hedgehog (Shh) and Wnt developmental signaling pathways, which are known to regulate tumor-initiating cells in malignant brain neoplasms...
September 2, 2016: Human Pathology
Yaqi Song, Xinle Kang, Gang Cao, Yongqiang Li, Xilei Zhou, Yusuo Tong, Wanwei Wang
BACKGROUND & AIMS: This study is designed for the clinical characteristics and prognostic factors of central neurocytoma (CN). METHODS: CN patients from 2004 to 2012 were enrolled from the Surveillance Epidemiology and End Results (SEER) data. Clinical characteristics including age, sex, race, tumor size, tumor number, surgery, and radiation therapy were summarized. Univariate and multivariate analysis were performed to explore the prognostic factors of CN. RESULTS: CN tended to be borderline malignant and single lesion...
August 11, 2016: Oncotarget
Wen-Chiuan Tsai, Dueng-Yuan Hueng, Shin Nieh, Hong-Wei Gao
AIMS: Although ARID4B is known to promote tumour metastasis in breast cancer and inhibit transformation and progression in leukaemia, the possible effect of ARID4B on primary brain tumours (PBTs) is not well characterised. We tested the hypothesis that expression of ARID4B correlates with WHO grade and survival in patients with PBTs. METHODS: Western blot analysis was performed on protein lysates prepared from normal brain tissue and glioma cell lines (U87MG, LN229, GBM8401 and U118MG)...
July 22, 2016: Journal of Clinical Pathology
Megha Nayyar, Mary Catherine Mayo, Mark Shiroishi, Deborah Commins, Charles Y Liu, John L Go, Paul E Kim, Chi-Shing Zee, Meng Law, Alexander Lerner
Central neurocytomas comprise nearly half of adult intraventricular neoplasms. The median age of onset is 34 years. It is typically a low-grade neoplasm (World Health Organization grade II), although some cases of malignant neurocytomas have been described. We present a rare case of an atypical central neurocytoma with craniospinal dissemination, including both imaging and pathologic findings.
June 15, 2016: Clinical Imaging
Stergios Zacharoulis, Andres Morales La Madrid, Pratiti Bandopadhayay, Susan N Chi, Peter Manley, Nicole N J Ullrich, Karen Marcus, Liliana Goumnerova, Robert M Scott, Mark Proctor, Tina Young-Poussaint, Umberto De Girolami, Mark W Kieran
BACKGROUND: Central neurocytomas (CN) are rare pediatric CNS tumors most often with a benign clinical course. Occasionally, these tumors occur outside the ventricles and are called extraventricular neurocytomas (EVN). We present a retrospective institutional analysis of children with neurocytoma with prolonged follow-up. PROCEDURE: Twelve patients were diagnosed with neurocytoma at our institution between 1993 and 2004. RESULTS: Six patients were male and the median age at diagnosis was 12 years (1...
August 2016: Journal of Pediatric Hematology/oncology
Jie Wang, Dong-Lei Song, Li Deng, Shu-Yan Sun, Chun Liu, De-Shan Gong, Yin Wang, Qi-Wu Xu
INTRODUCTION: The extraventricular neurocytoma of the sellar region (EVNSR) is a rare disease, it is difficult to make exact diagnosis of and operate on patients. Retrospectively analysed the clinical manifestations, image features, therapy methods and outcomes among patients with EVNSR, to investigate the epidemiological characteristics, image features, diagnosis, treatment and prognosis. CASE DESCRIPTION: A 25-year-old man man with 7-month worsening vision of left eye, was confirmed EVNSR after subtotally resection from the neurosurgical department of Deji hospital...
2016: SpringerPlus
Yu-Chen Ji, Jing-Xia Hu, Yan Li, Peng-Xiang Yan, Huan-Cong Zuo
Central neurocytoma (CNC) often develops in the ventricular system adjacent to the interventricular foramen and septum pellucidum. According to the World Health Organization, CNCs are classified as grade II tumors, and in recent years it has been reported that CNCs have occasionally occurred in rare areas of the central nervous system. The current study describes a rare case of CNC located in the left temporal lobe of a 49-year-old man, who had been experiencing headaches for 3 weeks. Computed tomography identified a round, well-demarcated, 3...
June 2016: Oncology Letters
Hirotomo Tanaka, Takashi Sasayama, Haruo Yamashita, Yoshie Hara, Shigeto Hayashi, Yusuke Yamamoto, Yuichi Fujita, Takeshi Okino, Takashi Mizowaki, Yoji Yamaguchi, Kazuhiro Tanaka, Eiji Kohmura
Although stereotactic radiosurgery (SRS) is effective for central neurocytoma (CN), the long-term outcome of SRS remains unclear. We present a case of recurrent CN that was diagnosed 10years after surgical resection and consecutive stereotactic radiotherapy. The patient was treated with SRS for the recurrent tumor, but underwent two-staged surgery once again due to rapid tumor growth. Histological features of the recurrent tumor were consistent with the diagnosis of CN. However, an increased Ki-67 proliferation index (3...
September 2016: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Mariachiara Quadrifoglio, Flavio Faletra, Rossana Bussani, Vanna Pecile, Floriana Zennaro, Alessandra Grasso, Lorenzo Zandonà, Salvatore Alberico, Tamara Stampalija
No abstract text is available yet for this article.
June 2016: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
Minjae Cho, Jin-Deok Joo, Baek-Hui Kim, Gheeyoung Choe, Chae-Yong Kim
Extra ventricular neurocytoma (EVN) is a rare brain tumor with histologic features similar with a central neurocytoma, but located outside of the ventricular system. In this study, we present an unusual case of hypothalamic EVN in a 14-year-old patient. The patient underwent subtotal removal and had tumor relapse. The patient was then treated using intensity modulated radiation therapy, and the tumor remained stable for 24 months. This case report may be important in that this is the first pediatric case of EVN located in the hypothalamic region...
April 2016: Brain Tumor Research and Treatment
Zhanlong Ma, Hailang Yan, Haibin Shi, Yan Li, Jiacheng Song, Junwen Huang, Xiongning Hong
There were few studies have documented the MRI features of typical and atypical CNCs for diagnosis and therapeutic modalities. Here, 18 histopathologically confirmed cases of intracranial CNCs (8 men and 10 women with a mean age of 28.3 years, range 10-64 years) were retrospectively analyzed. The histopathological and immunohistochemical features were also assessed. On MR imaging, the 14 typical cases of CNCs showed relatively round, lobulated tumor masses in the body of the right lateral ventricle (5 cases), left lateral ventricle (4 cases), third ventricles (2 cases), and midline (3 cases)...
July 2016: Clinical Neurology and Neurosurgery
Susan A Elmore, Cindy A Farman, James R Hailey, Ramesh C Kovi, David E Malarkey, James P Morrison, Jennifer Neel, Patricia A Pesavento, Brian F Porter, Kathleen A Szabo, Leandro B C Teixeira, Erin M Quist
The 2015 Annual National Toxicology Program Satellite Symposium, entitled "Pathology Potpourri" was held in Minneapolis, Minnesota, at the American College of Veterinary Pathologists/American Society for Veterinary Clinical Pathology/Society of Toxicologic Pathology combined meeting. The goal of this symposium is to present and discuss diagnostic pathology challenges or nomenclature issues. Because of the combined meeting, both laboratory and domestic animal cases were presented. This article presents summaries of the speakers' talks, including challenging diagnostic cases or nomenclature issues that were presented, along with select images that were used for audience voting and discussion...
June 2016: Toxicologic Pathology
Shailendra Ratre, Yad Ram Yadav, Vijay Singh Parihar, Yatin Kher
Background Retraction of the overlying brain can be difficult without causing significant trauma when using traditional brain retractors with blades. These retractors may produce focal pressure and may result in brain contusion or infarction. Tubular retractors offer the advantage of low retracting pressure that is less likely to be traumatic. Low retraction pressure in the tubular retractor is due to the distribution of retraction force in all directions in a larger area. Material and Methods We conducted a retrospective study of 100 patients with deep-seated tumors operated on from January 2010 to December 2014...
July 2016: Journal of Neurological Surgery. Part A, Central European Neurosurgery
Zubair Ahmad, Nasir Ud Din, Aisha Memon, Mohammad Usman Tariq, Romana Idrees, Sheema Hasan
BACKGROUND: Central neurocytomas are rare neuronal neoplasms with a favorable prognosis. They are typically located in the lateral ventricles of the brain and mostly histologically correspond to WHO grade II with a Mib 1 labelling index of <2%. Similar tumors located in the cerebral hemispheres and spinal cord, for example, are called "extraventricular neurocytomas". A few tumors histologically show atypia, mitoses, vascular proliferation and/or necrosis and a Mib 1 index >2 % and are designated as "atypical neurocytomas...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
Li Liang, Adriana Olar, Na Niu, Yi Jiang, Wenjun Cheng, Xiu-Wu Bian, Wentao Yang, Jing Zhang, Anna Yemelyanova, Anais Malpica, Zhihong Zhang, Gregory N Fuller, Jinsong Liu
Primary glial and neuronal tumors of the ovary or peritoneum are rare neuroectodermal-type tumors similar to their counterparts in the central nervous system. We retrospectively reviewed 11 cases. These cases included 4 ependymomas, 6 astrocytic tumors, and 1 neurocytoma. Patients' age ranged from 9 to 50 years (mean, 26 y; median, 24 y). All ependymal tumors with detailed clinical history (n=3) were not associated with any other ovarian neoplasm. In contrast, all astrocytic tumors were associated with immature teratoma (n=4), mature cystic teratoma (n=1), or mixed germ cell tumor (n=1)...
June 2016: American Journal of Surgical Pathology
Kazuhiro Yamanaka, Yoshiyasu Iwai, Takashi Shuto, Yoshihisa Kida, Mitsuya Sato, Motohiro Hayashi, Takeshi Kondo, Hisao Hirai, Rentaro Hori, Kenji Kubo, Hisae Mori, Osamu Nagano, Toru Serizawa
OBJECTIVE: Central neurocytoma (CN) is a rare benign neuronal tumor, and a limited number of reports have described the usefulness of radiosurgery for a relatively large group of patients. We evaluated the effectiveness and outcomes of Gamma Knife radiosurgery (GKS) for CN in a Japanese multi-institutional study. METHODS: We performed retrospective analysis of 36 patients with CN who were treated with GKS in 12 institutes in Japan. All patients underwent surgery before GKS...
June 2016: World Neurosurgery
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