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Steven ziegler

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https://www.readbyqxmd.com/read/27895126/versican-deficiency-significantly-reduces-lung-inflammatory-response-induced-by-polyinosine-polycytidylic-acid-stimulation
#1
Inkyung Kang, Ingrid A Harten, Mary Y Chang, Kathleen R Braun, Alyssa Sheih, Mary P Nivison, Pamela Y Johnson, Gail Workman, Gernot Kaber, Stephen P Evanko, Christina K Chan, Mervyn J Merrilees, Steven F Ziegler, Michael G Kinsella, Charles W Frevert, Thomas N Wight
Viral infection is an exacerbating factor contributing to chronic airway diseases such as asthma via mechanisms which are still unclear. Polyinosine-polycytidylic acid (poly I:C), a toll-like receptor (TLR) 3 agonist used as a mimetic to study viral infection, has been shown to elicit inflammatory responses in lungs and to exacerbate pulmonary allergic reactions in animal models. Previously, we have shown that poly I:C stimulates lung fibroblasts to accumulate an extracellular matrix (ECM), enriched in hyaluronan (HA) and its binding partner versican, which promotes monocyte adhesion...
November 28, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27815425/stat6-regulates-the-development-of-eosinophilic-versus-neutrophilic-asthma-in-response-to-alternaria-alternata
#2
Andrea C Valladao, Charles W Frevert, Lisa K Koch, Daniel J Campbell, Steven F Ziegler
Human asthma is a heterogeneous disease characterized by the expression of both Th2 and Th17 cytokines. In vitro and in vivo studies have shown a reciprocal regulation between Th2 and Th17 pathways, suggesting a potential induction of neutrophil-promoting Th17 inflammation in the absence of a Th2 response. Alternaria alternata is a clinically relevant allergen that is associated with severe and fatal asthma exacerbations. Exposure to A. alternata is characterized by a predominant Th2 response, but can also induce the production of factors associated with Th17 responses (e...
December 15, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27639653/assessment-of-kinematics-and-electromyography-following-arthroscopic-single-tendon-rotator-cuff-repair
#3
Jessica M Fritz, Ryan R Inawat, Brooke A Slavens, John R McGuire, Dean W Ziegler, Sergey S Tarima, Steven I Grindel, Gerald F Harris
BACKGROUND: The increasing demand for rotator cuff (RC) repair patients to return to work as soon as they are physically able has led to exploration of when this is feasible. Current guidelines from our orthopedic surgery clinic recommend a return to work at 9 weeks postoperation. To more fully define capacity to return to work, the current study was conducted using a unique series of quantitative tools. To date, no study has combined 3-dimensional (3D) motion analysis with electromyography (EMG) assessment during activities of daily living (ADLs), including desk tasks, and commonly prescribed rehabilitation exercise...
September 14, 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/27598620/modified-high-molecular-weight-hyaluronan-promotes-allergen-specific-immune-tolerance
#4
John A Gebe, Koshika Yadava, Shannon M Ruppert, Payton Marshall, Paul Hill, Ben A Falk, Johanna M Sweere, Hongwei Han, Gernot Kaber, Carlos Medina, Katalin Mikecz, Steven F Ziegler, Swathi Balaji, Sundeep G Keswani, Vinicio A de Jesus Perez, Manish J Butte, Kari Nadeau, William A Altemeier, Neil Fanger, Paul L Bollyky
BACKGROUND: The extracellular matrix in asthmatic lungs contains abundant low-molecular-weight hyaluronan (LMW-HA) and this is known to promote antigen presentation and allergic responses. Conversely, high-molecular-weight hyaluronan, typical of un-inflamed tissues, is known to suppress inflammation. OBJECTIVE: We asked whether HMW-HA can be adapted to adapted to promote tolerance to airway allergens. METHODS: HMW-HA was thiolated to prevent its catabolism and tethered it to allergens via thiol linkages...
September 6, 2016: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/27587788/a-meta-analysis-of-multiple-myeloma-risk-regions-in-african-and-european-ancestry-populations-identifies-putatively-functional-loci
#5
Kristin A Rand, Chi Song, Eric Dean, Daniel J Serie, Karen Curtin, Xin Sheng, Donglei Hu, Carol Ann Huff, Leon Bernal-Mizrachi, Michael H Tomasson, Sikander Ailawadhi, Seema Singhal, Karen Pawlish, Edward S Peters, Cathryn H Bock, Alex Stram, David J Van Den Berg, Christopher K Edlund, David V Conti, Todd Zimmerman, Amie E Hwang, Scott Huntsman, John Graff, Ajay Nooka, Yinfei Kong, Silvana L Pregja, Sonja I Berndt, William J Blot, John Carpten, Graham Casey, Lisa Chu, W Ryan Diver, Victoria L Stevens, Michael R Lieber, Phyllis J Goodman, Anselm J M Hennis, Ann W Hsing, Jayesh Mehta, Rick A Kittles, Suzanne Kolb, Eric A Klein, Cristina Leske, Adam B Murphy, Barbara Nemesure, Christine Neslund-Dudas, Sara S Strom, Ravi Vij, Benjamin A Rybicki, Janet L Stanford, Lisa B Signorello, John S Witte, Christine B Ambrosone, Parveen Bhatti, Esther M John, Leslie Bernstein, Wei Zheng, Andrew F Olshan, Jennifer J Hu, Regina G Ziegler, Sarah J Nyante, Elisa V Bandera, Brenda M Birmann, Sue A Ingles, Michael F Press, Djordje Atanackovic, Martha J Glenn, Lisa A Cannon-Albright, Brandt Jones, Guido Tricot, Thomas G Martin, Shaji K Kumar, Jeffrey L Wolf, Sandra L Deming Halverson, Nathaniel Rothman, Angela R Brooks-Wilson, S Vincent Rajkumar, Laurence N Kolonel, Stephen J Chanock, Susan L Slager, Richard K Severson, Nalini Janakiraman, Howard R Terebelo, Elizabeth E Brown, Anneclaire J De Roos, Ann F Mohrbacher, Graham A Colditz, Graham G Giles, John J Spinelli, Brian C Chiu, Nikhil C Munshi, Kenneth C Anderson, Joan Levy, Jeffrey A Zonder, Robert Z Orlowski, Sagar Lonial, Nicola J Camp, Celine M Vachon, Elad Ziv, Daniel O Stram, Dennis J Hazelett, Christopher A Haiman, Wendy Cozen
BACKGROUND: Genome-wide association studies (GWAS) in European populations have identified genetic risk variants associated with multiple myeloma. METHODS: We performed association testing of common variation in eight regions in 1,318 patients with multiple myeloma and 1,480 controls of European ancestry and 1,305 patients with multiple myeloma and 7,078 controls of African ancestry and conducted a meta-analysis to localize the signals, with epigenetic annotation used to predict functionality...
December 2016: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/27401342/unique-and-shared-signaling-pathways-cooperate-to-regulate-the-differentiation-of-human-cd4-t-cells-into-distinct-effector-subsets
#6
Cindy S Ma, Natalie Wong, Geetha Rao, Akira Nguyen, Danielle T Avery, Kathryn Payne, James Torpy, Patrick O'Young, Elissa Deenick, Jacinta Bustamante, Anne Puel, Satoshi Okada, Masao Kobayashi, Ruben Martinez-Barricarte, Michael Elliott, Sara Sebnem Kilic, Jamila El Baghdadi, Yoshiyuki Minegishi, Aziz Bousfiha, Nic Robertson, Sophie Hambleton, Peter D Arkwright, Martyn French, Annaliesse K Blincoe, Peter Hsu, Dianne E Campbell, Michael O Stormon, Melanie Wong, Stephen Adelstein, David A Fulcher, Matthew C Cook, Polina Stepensky, Kaan Boztug, Rita Beier, Aydan Ikincioğullari, John B Ziegler, Paul Gray, Capucine Picard, Stéphanie Boisson-Dupuis, Tri Giang Phan, Bodo Grimbacher, Klaus Warnatz, Steven M Holland, Gulbu Uzel, Jean-Laurent Casanova, Stuart G Tangye
Naive CD4(+) T cells differentiate into specific effector subsets-Th1, Th2, Th17, and T follicular helper (Tfh)-that provide immunity against pathogen infection. The signaling pathways involved in generating these effector cells are partially known. However, the effects of mutations underlying human primary immunodeficiencies on these processes, and how they compromise specific immune responses, remain unresolved. By studying individuals with mutations in key signaling pathways, we identified nonredundant pathways regulating human CD4(+) T cell differentiation in vitro...
July 25, 2016: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/27291797/female-chromosome-x-mosaicism-is-age-related-and-preferentially-affects-the-inactivated-x-chromosome
#7
Mitchell J Machiela, Weiyin Zhou, Eric Karlins, Joshua N Sampson, Neal D Freedman, Qi Yang, Belynda Hicks, Casey Dagnall, Christopher Hautman, Kevin B Jacobs, Christian C Abnet, Melinda C Aldrich, Christopher Amos, Laufey T Amundadottir, Alan A Arslan, Laura E Beane-Freeman, Sonja I Berndt, Amanda Black, William J Blot, Cathryn H Bock, Paige M Bracci, Louise A Brinton, H Bas Bueno-de-Mesquita, Laurie Burdett, Julie E Buring, Mary A Butler, Federico Canzian, Tania Carreón, Kari G Chaffee, I-Shou Chang, Nilanjan Chatterjee, Chu Chen, Constance Chen, Kexin Chen, Charles C Chung, Linda S Cook, Marta Crous Bou, Michael Cullen, Faith G Davis, Immaculata De Vivo, Ti Ding, Jennifer Doherty, Eric J Duell, Caroline G Epstein, Jin-Hu Fan, Jonine D Figueroa, Joseph F Fraumeni, Christine M Friedenreich, Charles S Fuchs, Steven Gallinger, Yu-Tang Gao, Susan M Gapstur, Montserrat Garcia-Closas, Mia M Gaudet, J Michael Gaziano, Graham G Giles, Elizabeth M Gillanders, Edward L Giovannucci, Lynn Goldin, Alisa M Goldstein, Christopher A Haiman, Goran Hallmans, Susan E Hankinson, Curtis C Harris, Roger Henriksson, Elizabeth A Holly, Yun-Chul Hong, Robert N Hoover, Chao A Hsiung, Nan Hu, Wei Hu, David J Hunter, Amy Hutchinson, Mazda Jenab, Christoffer Johansen, Kay-Tee Khaw, Hee Nam Kim, Yeul Hong Kim, Young Tae Kim, Alison P Klein, Robert Klein, Woon-Puay Koh, Laurence N Kolonel, Charles Kooperberg, Peter Kraft, Vittorio Krogh, Robert C Kurtz, Andrea LaCroix, Qing Lan, Maria Teresa Landi, Loic Le Marchand, Donghui Li, Xiaolin Liang, Linda M Liao, Dongxin Lin, Jianjun Liu, Jolanta Lissowska, Lingeng Lu, Anthony M Magliocco, Nuria Malats, Keitaro Matsuo, Lorna H McNeill, Robert R McWilliams, Beatrice S Melin, Lisa Mirabello, Lee Moore, Sara H Olson, Irene Orlow, Jae Yong Park, Ana Patiño-Garcia, Beata Peplonska, Ulrike Peters, Gloria M Petersen, Loreall Pooler, Jennifer Prescott, Ludmila Prokunina-Olsson, Mark P Purdue, You-Lin Qiao, Preetha Rajaraman, Francisco X Real, Elio Riboli, Harvey A Risch, Benjamin Rodriguez-Santiago, Avima M Ruder, Sharon A Savage, Fredrick Schumacher, Ann G Schwartz, Kendra L Schwartz, Adeline Seow, Veronica Wendy Setiawan, Gianluca Severi, Hongbing Shen, Xin Sheng, Min-Ho Shin, Xiao-Ou Shu, Debra T Silverman, Margaret R Spitz, Victoria L Stevens, Rachael Stolzenberg-Solomon, Daniel Stram, Ze-Zhong Tang, Philip R Taylor, Lauren R Teras, Geoffrey S Tobias, David Van Den Berg, Kala Visvanathan, Sholom Wacholder, Jiu-Cun Wang, Zhaoming Wang, Nicolas Wentzensen, William Wheeler, Emily White, John K Wiencke, Brian M Wolpin, Maria Pik Wong, Chen Wu, Tangchun Wu, Xifeng Wu, Yi-Long Wu, Jay S Wunder, Lucy Xia, Hannah P Yang, Pan-Chyr Yang, Kai Yu, Krista A Zanetti, Anne Zeleniuch-Jacquotte, Wei Zheng, Baosen Zhou, Regina G Ziegler, Luis A Perez-Jurado, Neil E Caporaso, Nathaniel Rothman, Margaret Tucker, Michael C Dean, Meredith Yeager, Stephen J Chanock
To investigate large structural clonal mosaicism of chromosome X, we analysed the SNP microarray intensity data of 38,303 women from cancer genome-wide association studies (20,878 cases and 17,425 controls) and detected 124 mosaic X events >2 Mb in 97 (0.25%) women. Here we show rates for X-chromosome mosaicism are four times higher than mean autosomal rates; X mosaic events more often include the entire chromosome and participants with X events more likely harbour autosomal mosaic events. X mosaicism frequency increases with age (0...
June 13, 2016: Nature Communications
https://www.readbyqxmd.com/read/27193440/endogenous-estrogens-estrogen-metabolites-and-breast-cancer-risk-in-postmenopausal-chinese-women
#8
Steven C Moore, Charles E Matthews, Xiao Ou Shu, Kai Yu, Mitchell H Gail, Xia Xu, Bu-Tian Ji, Wong-Ho Chow, Qiuyin Cai, Honglan Li, Gong Yang, David Ruggieri, Jennifer Boyd-Morin, Nathaniel Rothman, Robert N Hoover, Yu-Tang Gao, Wei Zheng, Regina G Ziegler
BACKGROUND: The role of estrogen metabolism in determining breast cancer risk and differences in breast cancer rates between high-incidence and low-incidence nations is poorly understood. METHODS: We measured urinary concentrations of estradiol and estrone (parent estrogens) and 13 estrogen metabolites formed by irreversible hydroxylation at the C-2, C-4, or C-16 positions of the steroid ring in a nested case-control study of 399 postmenopausal invasive breast cancer case participants and 399 matched control participants from the population-based Shanghai Women's Health Study cohort...
October 2016: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/27183651/correction-cd4-group-1-innate-lymphoid-cells-ilc-form-a-functionally-distinct-ilc-subset-that-is-increased-in-systemic-sclerosis
#9
Florence Roan, Thomas A Stoklasek, Elizabeth Whalen, Jerry A Molitor, Jeffrey A Bluestone, Jane H Buckner, Steven F Ziegler
No abstract text is available yet for this article.
May 1, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27165713/acute-blockade-of-il-25-in-a-colitis-associated-colon-cancer-model-leads-to-increased-tumor-burden
#10
Tennille D Thelen, Ryan M Green, Steven F Ziegler
Chronic inflammation within the gastrointestinal tract results in an increased risk for developing colorectal cancer. Epithelial cytokines, including interleukin-25 (IL-25), are produced in the colon and are critical for protection from parasites, but can also be pathogenic in the context of inflammatory bowel diseases and allergy. Whether IL-25 is involved in the progression from inflammation to cancer is still largely unexplored. Using a well-established murine model for colitis-induced colon cancer; we aimed to determine the role of IL-25 in this process...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27140479/division-of-labour-by-cd4-t-helper-cells
#11
Steven F Ziegler
No abstract text is available yet for this article.
July 2016: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/27126823/subepithelial-accumulation-of-versican-in-a-cockroach-antigen-induced-murine-model-of-allergic-asthma
#12
Stephen R Reeves, Gernot Kaber, Alyssa Sheih, Georgiana Cheng, Mark A Aronica, Mervyn J Merrilees, Jason S Debley, Charles W Frevert, Steven F Ziegler, Thomas N Wight
The extracellular matrix (ECM) is an important contributor to the asthmatic phenotype. Recent studies investigating airway inflammation have demonstrated an association between hyaluronan (HA) accumulation and inflammatory cell infiltration of the airways. The ECM proteoglycan versican interacts with HA and is important in the recruitment and activation of leukocytes during inflammation. We investigated the role of versican in the pathogenesis of asthmatic airway inflammation. Using cockroach antigen (CRA)-sensitized murine models of allergic asthma, we demonstrate increased subepithelial versican in the airways of CRA-treated mice that parallels subepithelial increases in HA and leukocyte infiltration...
June 2016: Journal of Histochemistry and Cytochemistry: Official Journal of the Histochemistry Society
https://www.readbyqxmd.com/read/27106789/mtorc2-mediates-cxcl12-induced-angiogenesis
#13
Mary E Ziegler, Michaela M S Hatch, Nan Wu, Steven A Muawad, Christopher C W Hughes
The chemokine CXCL12, through its receptor CXCR4, positively regulates angiogenesis by promoting endothelial cell (EC) migration and tube formation. However, the relevant downstream signaling pathways in EC have not been defined. Similarly, the upstream activators of mTORC2 signaling in EC are also poorly defined. Here, we demonstrate for the first time that CXCL12 regulation of angiogenesis requires mTORC2 but not mTORC1. We find that CXCR4 signaling activates mTORC2 as indicated by phosphorylation of serine 473 on Akt and does so through a G-protein- and PI3K-dependent pathway...
July 2016: Angiogenesis
https://www.readbyqxmd.com/read/26934097/thymic-stromal-lymphopoietin-improves-survival-and-reduces-inflammation-in-sepsis
#14
Adrian M Piliponsky, Asha Lahiri, Phuong Truong, Morgan Clauson, Nicholas J Shubin, Hongwei Han, Steven F Ziegler
The mechanisms that contribute to homeostasis of the immune system in sepsis are largely unknown. One study suggests a potential detrimental role for thymic stromal lymphopoietin (TSLP) in sepsis; however, the immune-regulatory effects of TSLP on myeloid cells within the intestinal microenvironment suggest the contrary. Our objective was to clarify TSLP's role in sepsis. Cecal ligation and puncture was performed in mice with total or myeloid-specific deficiency in the TSLP receptor (TSLPR). Survival was monitored closely, peritoneal fluids and plasma were analyzed for markers of inflammation, and myeloid cell numbers and their ability to produce inflammatory mediators was determined...
August 2016: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/26882250/contemplating-autoimmunity-in-the-aegean-islands
#15
Lucy S K Walker, Steven Ziegler, Burkhard Becher
The Greek island of Crete became host to lively discussions on immunoregulation as experts from around the world gathered for the 7th Aegean Conference on Autoimmunity in September 2015.
March 2016: Nature Immunology
https://www.readbyqxmd.com/read/26850199/novel-method-to-assess-arterial-insufficiency-in-rodent-hind-limb
#16
Matthew A Ziegler, Matthew R DiStasi, Steven J Miller, Michael C Dalsing, Joseph L Unthank
BACKGROUND: Lack of techniques to assess maximal blood flow capacity thwarts the use of rodent models of arterial insufficiency to evaluate therapies for intermittent claudication. We evaluated femoral vein outflow (VO) in combination with stimulated muscle contraction as a potential method to assess functional hind limb arterial reserve and therapeutic efficacy in a rodent model of subcritical limb ischemia. MATERIALS AND METHODS: VO was measured with perivascular flow probes at rest and during stimulated calf muscle contraction in young, healthy rats (Wistar Kyoto, WKY; lean Zucker rats, LZR) and rats with cardiovascular risk factors (spontaneously hypertensive [SHR]; obese Zucker rats [OZR]) with acute and/or chronic femoral arterial occlusion...
March 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/26685908/associations-between-unprocessed-red-and-processed-meat-poultry-seafood-and-egg-intake-and-the-risk-of-prostate-cancer-a-pooled-analysis-of-15-prospective-cohort-studies
#17
Kana Wu, Donna Spiegelman, Tao Hou, Demetrius Albanes, Naomi E Allen, Sonja I Berndt, Piet A van den Brandt, Graham G Giles, Edward Giovannucci, R Alexandra Goldbohm, Gary G Goodman, Phyllis J Goodman, Niclas Håkansson, Manami Inoue, Timothy J Key, Laurence N Kolonel, Satu Männistö, Marjorie L McCullough, Marian L Neuhouser, Yikyung Park, Elizabeth A Platz, Jeannette M Schenk, Rashmi Sinha, Meir J Stampfer, Victoria L Stevens, Shoichiro Tsugane, Kala Visvanathan, Lynne R Wilkens, Alicja Wolk, Regina G Ziegler, Stephanie A Smith-Warner
Reports relating meat intake to prostate cancer risk are inconsistent. Associations between these dietary factors and prostate cancer were examined in a consortium of 15 cohort studies. During follow-up, 52,683 incident prostate cancer cases, including 4,924 advanced cases, were identified among 842,149 men. Cox proportional hazard models were used to calculate study-specific relative risks (RR) and then pooled using random effects models. Results do not support a substantial effect of total red, unprocessed red and processed meat for all prostate cancer outcomes, except for a modest positive association for tumors identified as advanced stage at diagnosis (advanced(r))...
May 15, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/26606970/transcriptome-analysis-of-gvhd-reveals-aurora-kinase-a-as-a-targetable-pathway-for-disease-prevention
#18
Scott N Furlan, Benjamin Watkins, Victor Tkachev, Ryan Flynn, Sarah Cooley, Swetha Ramakrishnan, Karnail Singh, Cindy Giver, Kelly Hamby, Linda Stempora, Aneesah Garrett, Jingyang Chen, Kayla M Betz, Carly G K Ziegler, Gregory K Tharp, Steven E Bosinger, Daniel E L Promislow, Jeffrey S Miller, Edmund K Waller, Bruce R Blazar, Leslie S Kean
Graft-versus-host disease (GVHD) is the most common complication of hematopoietic stem cell transplant (HCT). However, our understanding of the molecular pathways that cause this disease remains incomplete, leading to inadequate treatment strategies. To address this, we measured the gene expression profile of nonhuman primate (NHP) T cells during acute GVHD. Utilizing microarray technology, we measured the expression profiles of CD3(+) T cells from five cohorts: allogeneic transplant recipients receiving (i) no immunoprophylaxis (No Rx), (ii) sirolimus monotherapy (Siro), (iii) tacrolimus-methotrexate (Tac-Mtx), as well as (iv) autologous transplant recipients (Auto) and (v) healthy controls (HC)...
November 25, 2015: Science Translational Medicine
https://www.readbyqxmd.com/read/26599207/a-comprehensive-analysis-of-common-and-rare-variants-to-identify-adiposity-loci-in-hispanic-americans-the-iras-family-study-irasfs
#19
Chuan Gao, Nan Wang, Xiuqing Guo, Julie T Ziegler, Kent D Taylor, Anny H Xiang, Yang Hai, Steven J Kridel, Jerry L Nadler, Fouad Kandeel, Leslie J Raffel, Yii-Der I Chen, Jill M Norris, Jerome I Rotter, Richard M Watanabe, Lynne E Wagenknecht, Donald W Bowden, Elizabeth K Speliotes, Mark O Goodarzi, Carl D Langefeld, Nicholette D Palmer
Obesity is growing epidemic affecting 35% of adults in the United States. Previous genome-wide association studies (GWAS) have identified numerous loci associated with obesity. However, the majority of studies have been completed in Caucasians focusing on total body measures of adiposity. Here we report the results from genome-wide and exome chip association studies focusing on total body measures of adiposity including body mass index (BMI), percent body fat (PBF) and measures of fat deposition including waist circumference (WAIST), waist-hip ratio (WHR), subcutaneous adipose tissue (SAT), and visceral adipose tissue (VAT) in Hispanic Americans (nmax = 1263) from the Insulin Resistance Atherosclerosis Family Study (IRASFS)...
2015: PloS One
https://www.readbyqxmd.com/read/26320033/alcohol-consumption-and-breast-cancer-risk-by-estrogen-receptor-status-in-a-pooled-analysis-of-20-studies
#20
Seungyoun Jung, Molin Wang, Kristin Anderson, Laura Baglietto, Leif Bergkvist, Leslie Bernstein, Piet A van den Brandt, Louise Brinton, Julie E Buring, A Heather Eliassen, Roni Falk, Susan M Gapstur, Graham G Giles, Gary Goodman, Judith Hoffman-Bolton, Pamela L Horn-Ross, Manami Inoue, Laurence N Kolonel, Vittorio Krogh, Marie Lof, Paige Maas, Anthony B Miller, Marian L Neuhouser, Yikyung Park, Kim Robien, Thomas E Rohan, Stephanie Scarmo, Leo J Schouten, Sabina Sieri, Victoria L Stevens, Schoichiro Tsugane, Kala Visvanathan, Lynne R Wilkens, Alicja Wolk, Elisabete Weiderpass, Walter C Willett, Anne Zeleniuch-Jacquotte, Shumin M Zhang, Xuehong Zhang, Regina G Ziegler, Stephanie A Smith-Warner
BACKGROUND: Breast cancer aetiology may differ by estrogen receptor (ER) status. Associations of alcohol and folate intakes with risk of breast cancer defined by ER status were examined in pooled analyses of the primary data from 20 cohorts. METHODS: During a maximum of 6-18 years of follow-up of 1 089 273 women, 21 624 ER+ and 5113 ER- breast cancers were identified. Study-specific multivariable relative risks (RRs) were calculated using Cox proportional hazards regression models and then combined using a random-effects model...
June 2016: International Journal of Epidemiology
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