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JOURNAL ARTICLE
Carrie-Anne Malinczak, Wendy Fonseca, Steven M Hrycaj, Susan B Morris, Andrew J Rasky, Kazuma Yagi, Deneen M Wellik, Steven F Ziegler, Rachel L Zemans, Nicholas W Lukacs
Early-life respiratory virus infections have been correlated with enhanced development of childhood asthma. In particular, significant numbers of RSV-hospitalized infants go on to develop lung disease. It has been suggested that early-life viral infections may lead to altered lung development or repair that negatively impacts lung function later in life. Our data demonstrate that early-life RSV infection modifies lung structure, leading to decreased lung function. At 5 weeks post-neonatal RSV infection, significant defects are observed in baseline pulmonary function test (PFT) parameters consistent with decreased lung function as well as enlarged alveolar spaces...
January 30, 2024: American Journal of Physiology. Lung Cellular and Molecular Physiology
#2
JOURNAL ARTICLE
Geoffrey T Norris, Joshua M Ames, Steven F Ziegler, Andrew Oberst
In order to recover from infection, organisms must balance robust immune responses to pathogens with the tolerance of immune-mediated pathology. This balance is particularly critical within the central nervous system, whose complex architecture, essential function, and limited capacity for self-renewal render it susceptible to both pathogen- and immune-mediated pathology. Here, we identify the alarmin IL-33 and its receptor ST2 as critical for host survival to neuroinvasive flavivirus infection. We identify oligodendrocytes as the critical source of IL-33, and microglia as the key cellular responders...
November 20, 2023: PLoS Pathogens
#3
JOURNAL ARTICLE
Eric D Morrell, Sarah E Holton, Matthew Lawrance, Marika Orlov, Zoie Franklin, Mallorie A Mitchem, Hannah DeBerg, Vivian H Gersuk, Ashley Garay, Elizabeth Barnes, Ted Liu, Ithan D Peltan, Angela Rogers, Steven Ziegler, Mark M Wurfel, Carmen Mikacenic
The transcriptional and phenotypic characteristics that define alveolar monocyte and macrophage subsets in acute hypoxemic respiratory failure (AHRF) are poorly understood. Here, we apply CITE-seq (single-cell RNA-sequencing and cell-surface protein quantification) to bronchoalveolar lavage and blood specimens longitudinally collected from participants with AHRF to identify alveolar myeloid subsets, and then validate their identity in an external cohort using flow cytometry. We identify alveolar myeloid subsets with transcriptional profiles that differ from other lung diseases as well as several subsets with similar transcriptional profiles as reported in healthy participants (Metallothionein) or patients with COVID-19 (CD163/LGMN)...
November 17, 2023: Nature Communications
#4
JOURNAL ARTICLE
Aaron Domack, Morgan M Sandelski, Syed Ali, Keith E Blackwell, Marisa Buchakjian, Andrés M Bur, Steven B Cannady, Carlos X Castellanos, Yadranko Ducic, Tamer A Ghanem, Andrew T Huang, Ryan S Jackson, Niels Kokot, Shawn Li, Patrik Pipkorn, Sidharth V Puram, Rod Rezaee, Karthik Rajasekaran, Yelizaveta Shnayder, Uttam K Sinha, Daniel Sukato, Neeraj Suresh, Akina Tamaki, Carissa M Thomas, Eric J Thorpe, Mark K Wax, Sara Yang, Andrea Ziegler, Amy L Pittman
INTRODUCTION: Coronavirus disease 2019 (COVID-19) affects the vascular system, subjecting patients to a hypercoagulable state. This is of particular concern for the success of microvascular free flap reconstruction. This study aims to report head and neck free flap complications in patients with COVID-19 during the perioperative period. We believe these patients are more likely to experience flap complications given the hypercoagulable state. METHODS: This is a multi-institutional retrospective case series of patients infected with COVID-19 during the perioperative period for head and neck free flap reconstruction from March 2020 to January 2022...
November 8, 2023: Laryngoscope
#5
JOURNAL ARTICLE
Jenny Wegert, Anne Kristin Fischer, Balazs Palhazi, Taryn D Treger, Cäcilia Hilgers, Barbara Ziegler, Hyunchul Jung, Eva Jüttner, Andreas Waha, Jörg Fuchs, Steven W Warmann, Michael C Frühwald, Jochen Hubertus, Kathy Pritchard-Jones, Norbert Graf, Sam Behjati, Rhoikos Furtwängler, Manfred Gessler, Christian Vokuhl
Wilms tumors (WTs) are histologically diverse childhood cancers with variable contributions of blastema, stroma, and epithelia. A variety of cancer genes operate in WTs, including the tripartite-motif-containing-28 gene (TRIM28). Case reports and small case series suggest that TRIM28 mutations are associated with epithelial morphology and WT predisposition. Here, we systematically investigated the prevalence of TRIM28 inactivation and predisposing mutations in a cohort of 126 WTs with >2/3 epithelial cells, spanning 20 years of biobanking in the German SIOP93-01/GPOH and SIOP2001/GPOH studies...
October 4, 2023: Journal of Pathology
#6
Jeffrey A Tomalka, Anna Owings, Michelle Galeas-Pena, Carly G K Ziegler, Tanya O Robinson, Thomas G Wichman, Hannah Laird, Haley B Williams, Neha S Dhaliwal, Steven Everman, Yousaf Zafar, Alex K Shalek, Bruce H Horwitz, Jose Ordovas-Montanes, Sarah C Glover, Yann Gibert
BACKGROUND: Many questions remain unanswered regarding the implication of lipid metabolites in severe SARS-CoV-2 infections. By re-analyzed sequencing data from the nasopharynx of a previously published cohort, we found that alox genes, involved in eicosanoid synthesis, were up-regulated in high WHO score patients, especially in goblet cells. Herein, we aimed to further understand the roles played by eicosanoids during severe SARS-CoV-2 infection. METHODS AND FINDINGS: We performed a total fatty acid panel on plasma and bulk RNA-seq analysis on peripheral blood mononuclear cells (PBMCs) collected from 10 infected and 10 uninfected patients...
September 15, 2023: medRxiv
#7
JOURNAL ARTICLE
David A Levine, Namita E Mathew, Emily H Jung, Jiong Yan, Nancy J Newman, Praneetha Thulasi, Steven Yeh, Thomas R Ziegler, Jill Wells, Nieraj Jain
PURPOSE: To explore the risk factors and fundus imaging features of vitamin A deficiency retinopathy (VADR) in an academic tertiary referral center in Atlanta, GA USA, and to propose guidance regarding diagnostic workup and management of affected patients. DESIGN: Single center retrospective case series. SUBJECTS: Nine patients seen between 2015 and 2021 at the Emory Eye Center diagnosed with VADR. METHODS: Retrospective chart review...
September 4, 2023: Ophthalmology Retina
#8
JOURNAL ARTICLE
Neil R Ming, Deanna Noble, Steven Chussid, Alban Ziegler, Wendy K Chung
BACKGROUND: Children with neurodevelopmental disorders (NDDs) often have poor oral health and dental abnormalities. An increasing number of genes have been associated with neurodevelopmental conditions affecting the oral cavity, but the specific dental features associated with many genes remain unknown. AIM: To report the types and frequencies of dental manifestations in children with neurodevelopmental conditions of known genetic cause. DESIGN: A 30-question survey assesing ectodermal and dental features was administered through Simons Searchlight, with which formed a recontactable cohort of individuals with genetic NDDs often associated with autism spectrum disorder (ASD)...
September 1, 2023: International Journal of Paediatric Dentistry
#9
JOURNAL ARTICLE
Claire Fortunel, Clément Stahl, Sabrina Coste, Camille Ziegler, Géraldine Derroire, Sébastien Levionnois, Isabelle Maréchaux, Damien Bonal, Bruno Hérault, Fabien H Wagner, Lawren Sack, Jérôme Chave, Patrick Heuret, Steven Jansen, Grace John, Christine Scoffoni, Santiago Trueba, Megan K Bartlett
Water stress can cause declines in plant function that persist after rehydration. Recent work has defined 'resilience' traits characterizing leaf resistance to persistent damage from drought, but whether these traits predict resilience in whole-plant function is unknown. It is also unknown whether the coordination between resilience and 'resistance' - the ability to maintain function during drought - observed globally occurs within ecosystems. For eight rainforest species, we dehydrated and subsequently rehydrated leaves, and measured water stress thresholds for declines in rehydration capacity and maximum quantum yield of photosystem II (Fv /Fm )...
May 24, 2023: New Phytologist
#10
JOURNAL ARTICLE
Ryan C Murphy, Ying Lai, Matthew Liu, Taha Al-Shaikhly, Matthew C Altman, William A Altemeier, Charles W Frevert, Jason S Debley, Adrian M Piliponsky, Steven F Ziegler, Sina A Gharib, Teal S Hallstrand
Rationale: Indirect airway hyperresponsiveness (AHR) is a highly specific feature of asthma, but the underlying mechanisms responsible for driving indirect AHR remain incompletely understood. Objectives: To identify differences in gene expression in epithelial brushings obtained from individuals with asthma who were characterized for indirect AHR in the form of exercise-induced bronchoconstriction (EIB). Methods: RNA-sequencing analysis was performed on epithelial brushings obtained from individuals with asthma with EIB ( n = 11) and without EIB ( n = 9)...
June 15, 2023: American Journal of Respiratory and Critical Care Medicine
#11
Sarah E Holton, Mallorie Mitchem, Sudhakar Pipavath, Eric D Morrell, Pavan K Bhatraju, Jessica A Hamerman, Cate Speake, Uma Malhotra, Mark M Wurfel, Steven Ziegler, Carmen Mikacenic
Acute respiratory distress syndrome (ARDS) has a fibroproliferative phase that may be followed by pulmonary fibrosis. This has been described in patients with COVID-19 pneumonia, but the underlying mechanisms have not been completely defined. We hypothesized that protein mediators of tissue remodeling and monocyte chemotaxis are elevated in the plasma and endotracheal aspirates of critically ill patients with COVID-19 who subsequently develop radiographic fibrosis. We enrolled COVID-19 patients admitted to the ICU who had hypoxemic respiratory failure, were hospitalized and alive for at least 10 days, and had chest imaging done during hospitalization ( n = 119)...
May 1, 2023: medRxiv
#12
Geoffrey T Norris, Joshua M Ames, Steven F Ziegler, Andrew Oberst
UNLABELLED: In order to recover from infection, organisms must balance robust immune responses to pathogens with the tolerance of immune-mediated pathology. This balance is particularly critical within the central nervous system, whose complex architecture, essential function, and limited capacity for self-renewal render it susceptible to both pathogen-and immune-mediated pathology. Here, we identify the alarmin IL-33 and its receptor ST2 as critical for host survival to neuroinvasive flavivirus infection...
April 12, 2023: bioRxiv
#13
JOURNAL ARTICLE
Xin Chen, Thomas Dong, Yuhui Hu, Raffaella De Pace, Rafael Mattera, Kathrin Eberhardt, Marvin Ziegler, Terry Pirovolakis, Mustafa Sahin, Juan S Bonifacino, Darius Ebrahimi-Fakhari, Steven J Gray
Spastic paraplegia 50 (SPG50) is an ultrarare childhood-onset neurological disorder caused by biallelic loss-of-function variants in the AP4M1 gene. SPG50 is characterized by progressive spastic paraplegia, global developmental delay, and subsequent intellectual disability, secondary microcephaly, and epilepsy. We preformed preclinical studies evaluating an adeno-associated virus (AAV)/AP4M1 gene therapy for SPG50 and describe in vitro studies that demonstrate transduction of patient-derived fibroblasts with AAV2/AP4M1, resulting in phenotypic rescue...
May 15, 2023: Journal of Clinical Investigation
#14
JOURNAL ARTICLE
Honyin Chiu, Peter S Linsley, Steven F Ziegler
The thymus is an intricate organ consisting of a diverse population of thymic epithelial cells (TECs). Cortical and medullary TECs and their subpopulations have distinct roles in coordinating the development and selection of functionally competent and self-tolerant T cells. Recent advances made in technologies such as single-cell RNA sequencing have made it possible to investigate and resolve the heterogeneity in TECs. These findings have provided further understanding of the molecular mechanisms regulating TEC function and expression of tissue-restricted Ags...
April 1, 2023: Journal of Immunology
#15
JOURNAL ARTICLE
Tadamichi Kasuya, Shigeru Tanaka, Jun Tamura, Keishi Etori, Jumpei Shoda, Koto Hattori, Yusuke Endo, Masayuki Kitajima, Takahiro Kageyama, Taro Iwamoto, Masaya Yokota, Arifumi Iwata, Akira Suto, Kotaro Suzuki, Harumi Suzuki, Steven F Ziegler, Hiroshi Nakajima
Epithelial cells control a variety of immune cells by secreting cytokines to maintain tissue homeostasis on mucosal surfaces. Regulatory T (Treg) cells are essential for immune homeostasis and for preventing tissue inflammation; however, the precise molecular mechanisms by which epithelial cell-derived cytokines function on Treg cells in the epithelial tissues are not well understood. Here, we show that peripheral Treg cells preferentially respond to thymic stromal lymphoprotein (TSLP). Although TSLP does not affect thymic Treg differentiation, TSLP receptor-deficient induced Treg cells derived from naïve CD4+ T cells are less activated in an adoptive transfer model of colitis...
January 30, 2023: Scientific Reports
#16
JOURNAL ARTICLE
Ryan C Murphy, Ying Lai, Matthew C Altman, Kaitlyn A Barrow, Kimberly A Dill-McFarland, Matthew Liu, Jessica A Hamerman, Adam Lacy-Hulbert, Adrian M Piliponsky, Steven F Ziegler, William A Altemeier, Jason S Debley, Sina A Gharib, Teal S Hallstrand
BACKGROUND: Mast cells (MCs) within the airway epithelium in asthma are closely related to airway dysfunction, but cross talk between airway epithelial cells (AECs) and MCs in asthma remains incompletely understood. Human rhinovirus (RV) infections are key triggers for asthma progression, and AECs from individuals with asthma may have dysregulated antiviral responses. OBJECTIVE: We utilized primary AECs in an ex vivo coculture model system to examine cross talk between AECs and MCs after epithelial rhinovirus infection...
June 2023: Journal of Allergy and Clinical Immunology
#17
JOURNAL ARTICLE
Robin van der Ploeg, Margot J Cramwinckel, Ilja J Kocken, Thomas J Leutert, Steven M Bohaty, Chris D Fokkema, Pincelli M Hull, A Nele Meckler, Jack J Middelburg, Inigo A Müller, Donald E Penman, Francien Peterse, Gert-Jan Reichart, Philip F Sexton, Maximilian Vahlenkamp, David De Vleeschouwer, Paul A Wilson, Martin Ziegler, Appy Sluijs
Quantitative reconstructions of hydrological change during ancient greenhouse warming events provide valuable insight into warmer-than-modern hydrological cycles but are limited by paleoclimate proxy uncertainties. We present sea surface temperature (SST) records and seawater oxygen isotope (δ18 Osw ) estimates for the Middle Eocene Climatic Optimum (MECO), using coupled carbonate clumped isotope (Δ47 ) and oxygen isotope (δ18 Oc ) data of well-preserved planktonic foraminifera from the North Atlantic Newfoundland Drifts...
January 25, 2023: Science Advances
#18
JOURNAL ARTICLE
Phillip P Domeier, Ziaur S M Rahman, Steven F Ziegler
Long-lived and high-affinity antibodies are derived from germinal center (GC) activity, but the cytokines that regulate GC function are still being identified. Here, we show that thymic stromal lymphopoietin (TSLP) signaling regulates the GC and the magnitude of antigen-specific antibody responses. Both GC B cells and T follicular helper (TFH ) cells up-regulate the expression of surface TSLP receptor (TSLPR), but cell-specific loss of TSLPR results in distinct effects on GC formation and antibody production...
January 6, 2023: Science Immunology
#19
JOURNAL ARTICLE
Lomon So, Kazushige Obata-Ninomiya, Alex Hu, Virginia S Muir, Ayako Takamori, Jing Song, Jane H Buckner, Ram Savan, Steven F Ziegler
Regulatory T cells (Tregs) suppress the activation and subsequent effector functions of CD4 effector T cells (Teffs). However, molecular mechanisms that enforce Treg-mediated suppression in CD4 Teff are unclear. We found that Tregs suppressed activation-induced global protein synthesis in CD4 Teffs prior to cell division. We analyzed genome-wide changes in the transcriptome and translatome of activated CD4 Teffs. We show that mRNAs encoding for the protein synthesis machinery are regulated at the level of translation in activated CD4 Teffs by Tregs...
March 6, 2023: Journal of Experimental Medicine
#20
REVIEW
Hélène Ralimanana, Allison L Perrigo, Rhian J Smith, James S Borrell, Søren Faurby, Mamy Tiana Rajaonah, Tianjanahary Randriamboavonjy, Maria S Vorontsova, Robert S C Cooke, Leanne N Phelps, Ferran Sayol, Niels Andela, Tobias Andermann, Andotiana M Andriamanohera, Sylvie Andriambololonera, Steven P Bachman, Christine D Bacon, William J Baker, Francesco Belluardo, Chris Birkinshaw, Stuart Cable, Nataly A Canales, Juan D Carrillo, Rosie Clegg, Colin Clubbe, Angelica Crottini, Gabriel Damasco, Sonia Dhanda, Daniel Edler, Harith Farooq, Paola de Lima Ferreira, Brian L Fisher, Félix Forest, Lauren M Gardiner, Steven M Goodman, Olwen M Grace, Thaís B Guedes, Jan Hackel, Marie C Henniges, Rowena Hill, Caroline E R Lehmann, Porter P Lowry, Lovanomenjanahary Marline, Pável Matos-Maraví, Justin Moat, Beatriz Neves, Matheus G C Nogueira, Renske E Onstein, Alexander S T Papadopulos, Oscar A Perez-Escobar, Peter B Phillipson, Samuel Pironon, Natalia A S Przelomska, Marina Rabarimanarivo, David Rabehevitra, Jeannie Raharimampionona, Fano Rajaonary, Landy R Rajaovelona, Mijoro Rakotoarinivo, Amédée A Rakotoarisoa, Solofo E Rakotoarisoa, Herizo N Rakotomalala, Franck Rakotonasolo, Berthe A Ralaiveloarisoa, Myriam Ramirez-Herranz, Jean Emmanuel N Randriamamonjy, Vonona Randrianasolo, Andriambolantsoa Rasolohery, Anitry N Ratsifandrihamanana, Noro Ravololomanana, Velosoa Razafiniary, Henintsoa Razanajatovo, Estelle Razanatsoa, Malin Rivers, Daniele Silvestro, Weston Testo, Maria F Torres Jiménez, Kim Walker, Barnaby E Walker, Paul Wilkin, Jenny Williams, Thomas Ziegler, Alexander Zizka, Alexandre Antonelli
Madagascar's unique biota is heavily affected by human activity and is under intense threat. Here, we review the current state of knowledge on the conservation status of Madagascar's terrestrial and freshwater biodiversity by presenting data and analyses on documented and predicted species-level conservation statuses, the most prevalent and relevant threats, ex situ collections and programs, and the coverage and comprehensiveness of protected areas. The existing terrestrial protected area network in Madagascar covers 10...
December 2, 2022: Science
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