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https://www.readbyqxmd.com/read/28927447/protecting-effect-of-prp-codons-m142-and-k222-in-goats-orally-challenged-with-bovine-spongiform-encephalopathy-prions
#1
C Fast, W Goldmann, P Berthon, K Tauscher, O Andréoletti, I Lantier, C Rossignol, A Bossers, J G Jacobs, N Hunter, M H Groschup, F Lantier, J P M Langeveld
Breeding towards genetic resistance to prion disease is effective in eliminating scrapie. In sheep, classical forms of scrapie have been eradicated almost completely in several countries by breeding programs using a prion protein (PrP) gene (PRNP) amino acid polymorphism. For goats, field and experimental studies have provided evidence for several amino acid polymorphisms that are associated with resistance to scrapie, but only limited data are available concerning the susceptibility of caprine PRNP genotypes to BSE...
September 19, 2017: Veterinary Research
https://www.readbyqxmd.com/read/28922031/optic-nerve-head-characteristics-in-chronic-angle-closure-glaucoma-detected-by-swept-source-oct
#2
Dejiao Li, Taibo Li, Eleftherios I Paschalis, Haobing Wang, Elise V Taniguchi, Zi-Ning Choo, Marissa K Shoji, Scott H Greenstein, Stacey C Brauner, Angela V Turalba, Louis R Pasquale, Lucy Q Shen
PURPOSE: To compare structural features in prelaminar and laminar tissues of the optic nerve head (ONH) in chronic angle closure glaucoma (CACG), primary open angle glaucoma (POAG), and control subjects. MATERIALS AND METHODS: ONH imaging was performed using swept-source optical coherence tomography (SS-OCT) for measurements of minimum rim width at Bruch's membrane opening (BMO-MRW), horizontal, and vertical lamina cribrosa depth (LCD). Prelaminar defects, categorized as hole and wedge, and lamina cribrosa (LC) defects were identified...
September 18, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28910946/-joint-effect-of-smoking-and-diabetes-on-stroke
#3
H Q Lou, Z M Dong, X P Shao, P Zhang, Y Shi, P P Chen, C Qiao, T Li, X Ding, P A Lou, X B Zhang
Objective: To explore the interaction of smoking and diabetes on stroke. Methods: In this case-control study, a face to face questionnaire survey was conducted. Logistic regression models were used to analyze the relationship between smoking or diabetes and stroke. The indicators of interaction were calculated according to the Bootstrap method in this study. Results: A total of 918 cases and 918 healthy controls, who participated in the chronic disease risk factor survey in Xuzhou in 2013, were included in this study...
September 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28910934/-analysis-on-epidemiology-and-spatial-temporal-clustering-of-human-brucellosis-in-fujian-province-2011-2016
#4
H S Zhu, L L Wang, D H Lin, R T Hong, J M Ou, W Chen, B P Wu, W L Huang, Z H Xie, G M Chen, S G Wu, Z B Xu, Y Q Deng
Objective: To analyze the epidemiological characteristics and spatial distribution of human brucellosis in Fujian province during 2011-2016, and provide evidence for the prevention and control of the disease. Methods: The surveillance data of human brucellosis in Fujian during 2011-2016 was analyzed with software R 3.3.1, ArcGIS 10.3.1, GeoDa 1.8.8 and SaTScan 9.4.3. Results: During 2011-2016, a total of 319 human brucellosis cases were reported, the incidence increased year by year (F=11.838, P=0.026) with the annual incidence of 0...
September 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28910896/-measurement-of-morphological-parameters-of-internal-acousticmeatus-using-thin-section-ct
#5
J M Liu, D D Zhu, G H Jin, X W Zhu, L Li, G W Liu, K L Cheng, Y Q Li
Objective: This study aimed to measure the morphological parameters of the internal acoustic meatus(IAM) and its adjacent structures using temporal-bone thin-section CT(computed tomography). Methods: CT images were obtained from 50 Chinese adult patients (25 males and 25 females, 100 sides) which had no visible lesion in the petrous part of the temporal bone and inner ear, the morphological parameters of all inner ear parts were sectionally measured on the specified plane using SPSS 22.0 software for statistical analysis...
September 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/28910891/-clinical-study-of-aged-patients-with-secondary-benign-paroxysmal-positional-vertigo
#6
Z J Zhu, L P Wei, Z X Xu, H J Xu, Q Liu, N Luo
Objective: To investigate the clinical features and evaluate the efficacy of manual reduction in treatment of age patients with secondary benign paroxysmal positional vertigo (s-BPPV). Methods: Thirty-two cases of aged patients ( the s-BPPV group: including 19 cases of female and 13 males, age from 60 to 86 years old)with secondary benign paroxysmal positional vertigo from Jul. 2013 to Sep. 2015 in our hospital were retrospectively analyzed. The results were compared with 121 patients( the primary group: including 82 cases of female and 39males, aged from 60 to 86 years old)with aged primary benign paroxysmal positional vertigo(p -BPPV)...
September 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/28910575/behaviour-of-biopolymeric-substances-in-the-activated-sludge-of-an-mbr-system-working-with-high-hydraulic-retention-time
#7
Eugenio Marín, Jorge I Pérez, Miguel A Gómez
This study was undertaken to analyse the activated sludge of a membrane bioreactor (MBR), the behaviour of extracellular polymeric substances (EPS) and soluble microbial products (SMP) as well as their biopolymers composition, in the activated sludge of a membrane bioreactor (MBR) and their influence on membrane fouling were analysed. For the experiment an experimental fullscale MBR working with real urban wastewater at high hydraulic retention time with a variable sludge-retention time (SRT) was used. The MBR system worked in denitrification/nitrification conformation at a constant flow rate (Q = 0...
September 14, 2017: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
https://www.readbyqxmd.com/read/28902930/association-between-polymorphisms-in-the-apob-gene-and-hyperlipidemia-in-the-chinese-yugur-population
#8
Q-L Gu, Y Han, Y-M Lan, Y Li, W Kou, Y-S Zhou, X-J Hai, B Yan, C-H Ci
We investigated the influence of apolipoprotein B gene (APOB) variants on the risk of hyperlipidemia (HL) in 631 middle-aged and elderly members of the Chinese Yugur population (HL, n=336; normolipidemia, n=295). APOB polymorphisms were identified using mass spectrometry, and five single nucleotide polymorphisms (rs1042034, rs2163204, rs512535, rs676210, and rs679899) and serum lipids were further analyzed. rs1042034 and rs676210 were significantly associated with HL (P<0.05). Compared with the GG or AA genotype, individuals with AG and AG+AA in rs1042034 and with AG and AG+GG in rs676210 had a 1...
September 12, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/28889771/helicobacter-pylori-infection-and-risk-of-preeclampsia-a-systematic-review-and-meta-analysis
#9
Malihe Nourollahpour Shiadeh, Seyed Mohammad Riahi, Ishag Adam, Vafa Saber, Zahra Behboodi Moghadam, Bahram Armon, Adel Spotin, Hajar Nazari Kangavari, Ali Rostami
OBJECTIVE: Helicobacter pylori is associated with many pregnancy adverse effects such as preeclampsia. We performed this systematic review and meta-analysis study to assess the possible association between H. pylori infection and preeclampsia (PE) and this is the first meta-analysis to clarify this issue. METHODS: PubMed, ISI (Web of science), SCOPUS and Google Scholar databases were searched (up to April 2017) to identify the relevant studies. The meta-analysis of observational studies in epidemiology (MOOSE) and PRISMA guidelines were used to do this study...
September 10, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28886326/mir-146a-rs2910164-polymorphism-might-be-associated-with-coronary-artery-disease-risk-in-asians
#10
H-Y Zhou, Q Wei, X-D Shi, H-Y Cao, L Qin
Recently, several studies reported the association between miR-146a rs2910164 polymorphism and coronary artery disease (CAD) risk. However, the results were inconclusive. We therefore did a meta-analysis to investigate this association. Electronic databases, including PubMed, EMBASE, and China National Knowledge Infrastructure (CNKI) databases, were searched. The strength of association was assessed by calculating odds ratios (OR) and 95% confidence interval (CI). Five eligible studies included in this meta-analysis...
August 30, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28875542/analysis-on-the-local-structures-for-3d-1-impurities-ti-3-and-v-4-in-ktipo4
#11
C C Ding, S Y Wu, L J Zhang, Y Q Xu, Z H Zhang, M H Wu, B H Teng
Making use of the perturbation formulae for 3d(1) ions (Ti(3+) and V(4+) ) under orthorhombically compressed octahedra, the spin Hamiltonian parameters (SHPs) (g factors: gx , gy , gz and hyperfine structure constants: Ax , Ay , Az ) and local structures of the 3d(1) impurity centres C1 , C2 and C3 in KTP crystals are theoretically analyzed in a consistent way. The remarkable local distortions (i.e., the relative axial compression ratios 11.2%, 7.0% and 5.5% along Z axis and the relative planar bond length variation ratios 15...
September 6, 2017: Magnetic Resonance in Chemistry: MRC
https://www.readbyqxmd.com/read/28873279/differences-in-bleeding-phenotype-and-provider-interventions-in-postmenarchal-adolescents-when-compared-to-adult-women-with-bleeding-disorders-and-heavy-menstrual-bleeding
#12
L V Srivaths, Q C Zhang, V R Byams, J E Dietrich, A H James, P A Kouides, R Kulkarni
INTRODUCTION: Due to lack of patient/health care provider awareness causing delayed diagnosis, the bleeding phenotype and provider interventions in adolescents with heavy menstrual bleeding (HMB) and bleeding disorders (BD) may be different when compared to adults. AIM: The aim of this study was to compare/characterize bleeding phenotype and provider interventions in postmenarchal adolescents < 18 years and premenopausal adults ≥ 18 years with HMB and BD...
September 5, 2017: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/28870034/-the-efficacy-and-safety-of-insulin-degludec-versus-insulin-glargine-in-insulin-naive-subjects-with-type-2-diabetes-results-of-a-chinese-cohort-from-a-multinational-randomized-controlled-trial
#13
Y M Mu, L X Guo, L Li, Y M Li, X J Xu, Q M Li, M T Xu, L Y Zhu, G Y Yuan, Y Liu, C Xu, Z J Wang, F X Shen, Y Luo, J Y Liu, Q F Li, W H Wang, X Y Lai, H F Xu, C Y Pan
Objective: To compare the safety and efficacy of insulin degludec (IDeg) with those of insulin glargine (IGlar) in insulin-naive subjects with type 2 diabetes (T2DM). Methods: This was a 26-week, randomized, open-label, parallel-group, treat-to-target trial in 560 Chinese subjects with T2DM (men/women: 274/263, mean age 56 years, mean diabetes duration 7 years) inadequately controlled on oral antidiabetic drugs (OADs). Subjects were randomized 2∶1 to once-daily IDeg (373 subjects) or IGlar(187 subjects), both in combination with metformin...
September 1, 2017: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/28870033/-the-expression-and-clinical-significance-of-proprotein-convertase-subtilisin-kexin-9-in-rheumatoid-arthritis
#14
Q Du, X J Yu, H J Li, S Q Guan, Z Y Zhang, Y F Mei
Objective: To assess the expression and significance of proprotein convertase subtilisin kexin 9 (PCSK9) in patients with rheumatoid arthritis (RA). Methods: Sixty-five RA patients and forty-seven healthy controls were recruited in this study. The body mass index (BMI) and serum total cholesterol(TC), triglyceride(TG), high density lipoprotein(HDL), lipoprotein a, low density lipoprotein(LDL), very low density lipoprotein(VLDL), apolipoprotein A(ApoA), apolipoprotein B(ApoB) and the ratio of LDL-C/HDL-C were tested...
September 1, 2017: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/28864942/a%C3%A2-dutch-myh7-founder-mutation-p-asn1918lys-is-associated-with-early-onset-cardiomyopathy-and-congenital-heart-defects
#15
I H M van der Linde, Y L Hiemstra, R Bökenkamp, A M van Mil, M H Breuning, C Ruivenkamp, S W Ten Broeke, R F Veldkamp, J I van Waning, M A van Slegtenhorst, K Y van Spaendonck-Zwarts, R H Lekanne Deprez, J C Herkert, L Boven, P A van der Zwaag, J D H Jongbloed, M Bootsma, D Q C M Barge-Schaapveld
BACKGROUND: Mutations in the myosin heavy chain 7 (MYH7) gene commonly cause cardiomyopathy but are less frequently associated with congenital heart defects. METHODS: In this study, we describe a mutation in the MYH7 gene, c. 5754C > G; p. (Asn1918Lys), present in 15 probands and 65 family members. RESULTS: Of the 80 carriers (age range 0-88 years), 46 (57.5%) had cardiomyopathy (mainly dilated cardiomyopathy (DCM)) and seven (8...
September 1, 2017: Netherlands Heart Journal
https://www.readbyqxmd.com/read/28847065/-interaction-between-polycyclic-aromatic-hydrocarbons-and-p16-fhit-gene-cpg-island-methylation-in-patients-with-cervical-intraepithelial-neoplasias
#16
L Wang, X Z Liu, Z Y Ren, L Ding, J Nan, C L Liu, Z C Song, M J Feng, Q Yang, J T Wang
Objective: To explore the effect of polycyclic aromatic hydrocarbons (PAHs) and p16, FHIT gene CpG island methylation, as well as their interaction in cervical intraepithelial neoplasias. Methods: Objects of this study were from a cohort of cervical lesions study in Yangqu county of Shanxi province. All the patients were diagnosed pathologically, that including 83 patients with high-grade cervical intraepithelial neoplasia (CINⅡ/Ⅲ), 86 patients with low-grade cervical intraepithelial neoplasia (CINⅠ) and another 91 women under normal cervical (NC) condition...
August 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28838743/total-serum-bilirubin-and-8-year-incident-type-2-diabetes-mellitus-the-korean-genome-and-epidemiology-study
#17
Y-J Kwon, Y-J Lee, B-J Park, K-W Hong, D-H Jung
AIM: In this study, the impact of serum bilirubin on new-onset type 2 diabetes mellitus (T2DM) in Korean adults was investigated. METHODS: Data were obtained from the Korean Genome and Epidemiology Study (KoGES), a population-based prospective cohort study. The study enrolled 8650 adults (4015 men and 4635 women), aged 40 to 69 years, who underwent a mean follow-up of 8.4 years. The study population was divided into quartiles (Q) of serum bilirubin levels, with cut-off points at 0...
August 21, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28835078/-killing-effect-of-icotinib-combined-with-cik-on-human-lung-adenocarcinoma-cells-in-vitro
#18
B Q Yao, Y Jia, J Q Guo, Q Zhao, H Sun, J P Zhang
Objective: To explore the inhibitory effect of icotinib combined with cytokine induced killer (CIK) on various human lung adenocarcinoma cell lines in vitro. Methods: The inhibitory effect of icotinib alone or icotinib combined with CIK on HCC827 and A549 cells was detected by cell counting kit-8(CCK-8). The apoptosis was detected by flow cytometry via Annexin V/PI staining. The effect of icotinib on CIK phenotype was detected by flow cytometry. Results: The inhibitory rates of HCC827 cells treated with 1.5, 3, 6, 12 μmol/L icotinib were (5...
August 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28827499/intrarater-reliability-of-muscle-strength-and-hamstring-to-quadriceps-strength-imbalance-ratios-during-concentric-isometric-and-eccentric-maximal-voluntary-contractions-using-the-isoforce-dynamometer
#19
Anett Mau-Moeller, Martin Gube, Sabine Felser, Frank Feldhege, Matthias Weippert, Florian Husmann, Thomas Tischer, Rainer Bader, Sven Bruhn, Martin Behrens
OBJECTIVE: To determine intrasession and intersession reliability of strength measurements and hamstrings to quadriceps strength imbalance ratios (H/Q ratios) using the new isoforce dynamometer. DESIGN: Repeated measures. SETTING: Exercise science laboratory. PARTICIPANTS: Thirty healthy subjects (15 females, 15 males, 27.8 years). MAIN OUTCOME MEASURES: Coefficient of variation (CV) and intraclass correlation coefficients (ICC) were calculated for (1) strength parameters, that is peak torque, mean work, and mean power for concentric and eccentric maximal voluntary contractions; isometric maximal voluntary torque (IMVT); rate of torque development (RTD), and (2) H/Q ratios, that is conventional concentric, eccentric, and isometric H/Q ratios (Hcon/Qcon at 60 deg/s, 120 deg/s, and 180 deg/s, Hecc/Qecc at -60 deg/s and Hiso/Qiso) and functional eccentric antagonist to concentric agonist H/Q ratios (Hecc/Qcon and Hcon/Qecc)...
August 17, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/28822455/-feasibility-analysis-of-predicting-the-risk-of-pancreatic-fistula-after-pancreatoduodenectomy-by-preoperative-ct
#20
M Yu, Y D Wang, H Z Xue, Q Shen, J Xu, X Zhang, J K Jia, M Jia
Objective: To study the preoperative computed tomography (CT) data of patients with pancreaticoduodenectomy (PD) and to explore the effective of predicting the risk of postoperative pancreatic fistula (POPF). Methods: CT images of patients with PD were analyzed retrospectively from June 2010 to January 2017 in Zhengzhou University of People's Hospital. The pancreas index, pancreatic duct width, pancreas CT value, pancreas-spleen CT value, and pancreas thickness were collected. The relationship between the indicators and the POPF was determined, and the receiver operation characteristic (ROC) curve was calculated and the area under the curve (AUC) was evaluated...
August 8, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
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