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Ciliary body melanoma

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https://www.readbyqxmd.com/read/27911584/clinicopathological-characteristics-and-prognosis-for-survival-after-enucleation-of-uveal-melanoma-in-chinese-patients-long-term-follow-up
#1
Han Yue, Jiang Qian, Yifei Yuan, Rui Zhang, Yingwen Bi, Fengxi Meng, Yi Xuan
PURPOSE: To summarize the clinicopathological characteristics and prognosis of uveal melanoma (UM) after enucleation in Chinese patients. METHODS: Between 2003 and 2012, a series of 171 patients with UM received enucleation at the Eye & ENT Hospital of Fudan University in Shanghai. Patient clinical information was collected. Pathological examination and BAP1 staining of the enucleated eyes were conducted. Univariate and multivariate Cox proportional hazard regressions were conducted to determine the risk factors, and the survival rates were calculated and compared...
December 2, 2016: Current Eye Research
https://www.readbyqxmd.com/read/27911450/uveal-melanoma-relatively-rare-but-deadly-cancer
#2
REVIEW
S Kaliki, C L Shields
Although it is a relatively rare disease, primarily found in the Caucasian population, uveal melanoma is the most common primary intraocular tumor in adults with a mean age-adjusted incidence of 5.1 cases per million per year. Tumors are located either in iris (4%), ciliary body (6%), or choroid (90%). The host susceptibility factors for uveal melanoma include fair skin, light eye color, inability to tan, ocular or oculodermal melanocytosis, cutaneous or iris or choroidal nevus, and BRCA1-associated protein 1 mutation...
December 2, 2016: Eye
https://www.readbyqxmd.com/read/27843898/nonteratoid-medulloepithelioma-presenting-in-a-78-year-old-male
#3
Christopher K H Burris, Vasilios P Papastefanou, Caroline Thaung, Gordon Hay, Marianne Grantham, Victoria M L Cohen
BACKGROUND: Medulloepithelioma is a rare congenital neoplasm derived from precursors of the nonpigmented ciliary epithelium of the ciliary body. The average patient age at clinical presentation is 3.8 years. CASE PRESENTATION: We present the case of a 78-year-old male with progressive lens subluxation and ocular hypertension who was found to have a ciliary body mass. After enucleation for presumed ciliary body melanoma, histopathology showed a nonteratoid medulloepithelioma...
October 2016: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/27835710/external-validation-of-the-liverpool-uveal-melanoma-prognosticator-online
#4
Sarah W DeParis, Azzam Taktak, Antonio Eleuteri, Wayne Enanoria, Heinrich Heimann, Sarah E Coupland, Bertil Damato
Purpose: To validate the Liverpool Uveal Melanoma Prognosticator Online (LUMPO) in a cohort of patients treated at the University of California-San Francisco (UCSF). Methods: A retrospective chart review was performed of 390 patients treated between 2002 and 2007 for choroidal melanoma at UCSF. Similar patients (n = 1175) treated at the Liverpool Ocular Oncology Centre (LOOC) were included in the study. The data were analyzed using the model previously developed for LUMPO, an online prognostication tool combining multiple prognostic factors...
November 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27800275/uveal-melanoma-current-trends-in-diagnosis-and-management
#5
REVIEW
Berçin Tarlan, Hayyam Kıratlı
Uveal melanoma, which is the most common primary intraocular malignancy in adults, arises from melanocytes within the iris, ciliary body and choroid. The diagnosis is based principally on clinical examination of the tumor with biomicroscopy and indirect ophthalmoscopy and confirmed by diagnostic techniques such as ultrasonography, fundus fluorescein angiography and optical coherence tomography. The clinical diagnosis of posterior uveal melanomas can be made when the classical appearance of a pigmented dome-shaped mass is detected on dilated fundus exam...
June 2016: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/27760647/-characteristics-of-retinal-and-scleral-infiltration-in-uveal-melanoma
#6
J Zhang, X L Xu, B Li, W B Wei
Objective: To analyze features of retinal and scleral infiltration of uveal melanoma. Methods: It was a retrospective case series study. The pathological and clinical data of 102 cases of uveal melanoma were analyzed retrospectively, which were collected between Jun. 2001 and Apr. 2013 in Beijing Tongren Hospital, Capital Medical University. The tumor shape, size, cell types, retinal and scleral invasion were recorded and analyzed. The relationship between retinal invasion and scleral invasion was analyzed by trend Chi-square test...
October 11, 2016: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/27713771/iridociliary-melanoma-clinical-case
#7
S Schmitzer, C Butea-Simionescu, A Gheorghe, M Zemba, M Cioboata
Iris and ciliary body melanoma is an aggressive tumor, which, unfortunately, presents symptoms only in advanced stages and is often discovered accidentally during a routine eye examination. There are several treatment options, ranging from in time monitorization in order to observe the tumor's evolution to more aggressive methods such as radiotherapy and enucleation. We present a case of iridociliary melanoma, who underwent conservative surgery, iridocyclectomy under scleral flap, with good results, and maintenance of the function and integrity of the eyeball...
January 2016: Journal of Medicine and Life
https://www.readbyqxmd.com/read/27688285/igg4-related-intraocular-inflammation-masquerading-as-ciliary-body-melanoma-in-a-young-girl
#8
Dipankar Das, Panna Deka, Geeta Verma, Ganesh Chandra Kuri, Harsha Bhattacharjee, Gayatri Bharali, Divya Pandey, Akanksha Koul, Bidisha Das, Apurba Deka
Immunoglobulin G4 (IgG4-related diseases) affects various tissues and organs of the human body. Orbital, adnexal, and scleral inflammations were already reported in the medical literature. To the best of our knowledge, we report the first case of intraocular IgG4-associated inflammatory mass in the ciliary body mimicking as a melanoma in a 23-year-old female from Northeast India. Characteristic histopathology, immunohistochemistry in the tissue, protein chemistry, and raised serum IgG4 were supportive for the diagnosis...
August 2016: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/27574179/episcleral-brachytherapy-of-uveal-melanoma-role-of-intraoperative-echographic-confirmation
#9
Hassan A Aziz, Yahya A Al Zahrani, James Bena, Brandy Lorek, Allan Wilkinson, John Suh, Arun D Singh
PURPOSE: To compare the rates of tumour recurrence following episcleral brachytherapy for uveal melanoma before and after implementation of intraoperative echographic confirmation of plaque placement. MATERIALS AND METHODS: All patients with primary single ciliary body or choroidal melanoma treated with iodine-125 or ruthenium-106 plaque brachytherapy between 1 January 2004 and 30 December 2013 were included. Exclusion criteria were patients with previous radiation treatment and patients who received adjuvant transpupillary thermotherapy...
August 29, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27562393/management-and-outcome-of-uveal-melanoma-in-a-single-tertiary-cancer-center-in-jordan
#10
Ahmed Zewar, Ibrahim Nawaiseh, Imad Jaradat, Jakub Khzouz, Khaleel Alrawashdeh, Ghadeer Abdeen, Mustafa Mehyar, Samer Khurma, Yacoub A Yousef
OBJECTIVE: The aim of this study was evaluate the features and outcome of management of uveal melanoma in King Hussein Cancer Center as an example of a referral tertiary cancer center in the Middle East. MATERIAL AND METHOD: This was aetrospective, observational case series of 46 eyes of 46 patients with uveal melanoma. Data collection required access to medical records, radiology and pathology reports, and laboratory results. The main outcome measures included age at diagnosis, tumor location and dimensions, TNM stage, treatment modality, visual outcome, metastasis, and mortality...
2016: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/27546281/adam-10-expression-in-primary-uveal-melanoma-as-prognostic-factor-for-risk-of-metastasis
#11
Rosario Caltabiano, Lidia Puzzo, Valeria Barresi, Antonio Ieni, Carla Loreto, Giuseppe Musumeci, Paola Castrogiovanni, Marco Ragusa, Pietro Foti, Andrea Russo, Antonio Longo, Michele Reibaldi
Uveal melanoma is the most frequent primary intraocular neoplasm in adults. Although malignant melanoma may be located at any point in the uveal tract, the choroid and ciliary body are more frequent locations than the iris. In the present study, we examined ADAM10 expression levels in primary uveal melanoma both with and without metastasis, and we evaluated their association with other high risk characteristics for metastasis in order to assess if ADAM10 can be used to predict metastasis. This study included a total of 52 patients, 23 men and 29 women, with uveal melanoma...
November 2016: Pathology, Research and Practice
https://www.readbyqxmd.com/read/27239456/amelanotic-irido-ciliary-ring-melanoma-a-clinicopathological-correlation
#12
Hassan A Aziz, Yasha S Modi, Thomas P Plesec, Arun D Singh
PURPOSE: To report a case of an amelanotic irido-ciliary ring melanoma. DESIGN: Interventional case report. RESULTS: A 44-year-old male was followed for asymptomatic amelanotic iris nevus of the right eye that was noted to have a localized ciliary body mass with ring extension along the trabecular meshwork. Fine needle aspiration biopsy was consistent with malignant melanoma. The patient underwent enucleation and remains disease free at 9 years of follow-up...
April 2016: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/27171682/diagnostic-and-management-challenges-of-ciliary-body-tumor-in-an-african-american-patient
#13
Sachin M Salvi, Arun D Singh
PURPOSE: To discuss the diagnostic and management challenges of a ciliary body tumor in an African-American patient. PROCEDURES: Our 52-year-old African-American female patient, referred with a nasal ciliary body tumor in the right eye, underwent investigations including A- and B-scan ultrasonography, Optos fundus photography and fundus fluorescein angiography at clinical consultation. A diagnostic fine-needle aspiration cytology and open flap biopsy were undertaken...
September 2015: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/27171272/outcomes-of-proton-beam-radiotherapy-for-large-non-peripapillary-choroidal-and-ciliary-body-melanoma-at-triumf-and-the-bc-cancer-agency
#14
Britta Weber, Katherine Paton, Roy Ma, Tom Pickles
BACKGROUND AND PURPOSE: To report outcomes and toxicity after proton beam radiotherapy for non-peripapillary choroidal and ciliary body melanoma considered unsuitable for other eye-sparing therapies. MATERIALS AND METHODS: An existing database of 77 patients with non-peripapillary tumors treated at TRIUMF, Canada, including patient, tumor, and treatment characteristics, was updated with ocular complications and follow-up status from chart reviews. RESULTS: Most of the patients had large tumors: 61% were T3/T4 tumors (AJCC classification), while 48% were large by the Collaborative Ocular Melanoma Study classification...
September 2015: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/27130243/clinical-and-histopathological-features-of-adenomas-of-the-ciliary-pigment-epithelium
#15
Ying Chang, Wen Bin Wei, Ji Tong Shi, Jun Fang Xian, Wen Li Yang, Xiao Lin Xu, Hai Xia Bai, Bin Li, Jost B Jonas
PURPOSE: Adenomas of the ciliary pigment epithelium (CPE) are rare benign tumours which have mainly to be differentiated from malignant ciliary body melanomas. Here we report on a consecutive series of patients with CPE adenomas and describe their characteristics. METHODS: The retrospective hospital-based case series study included all patients who were consecutively operated for CPE adenomas. RESULTS: Of the 110 patients treated for ciliary body tumours, five patients (4...
April 29, 2016: Acta Ophthalmologica
https://www.readbyqxmd.com/read/27123792/prognostic-implications-of-tumor-diameter-in-association-with-gene-expression-profile-for-uveal-melanoma
#16
Scott D Walter, Daniel L Chao, William Feuer, Joyce Schiffman, Devron H Char, J William Harbour
IMPORTANCE: Uveal melanoma (UM) can be divided into prognostically significant subgroups based on a prospectively validated and widely used 15-gene expression profile (GEP) test. Class 1 UMs have a low risk and class 2 UMs have a high risk for metastasis. OBJECTIVE: To determine whether any clinicopathologic factors provide independent prognostic information that may enhance the accuracy of the GEP classification. DESIGN, SETTING, AND PARTICIPANTS: This retrospective observational study performed at 2 ocular oncology referral centers included 339 patients in a primary cohort and 241 patients in a validation cohort...
July 1, 2016: JAMA Ophthalmology
https://www.readbyqxmd.com/read/27123562/driver-mutations-in-uveal-melanoma-associations-with-gene-expression-profile-and-patient-outcomes
#17
Christina L Decatur, Erin Ong, Nisha Garg, Hima Anbunathan, Anne M Bowcock, Matthew G Field, J William Harbour
IMPORTANCE: Frequent mutations have been described in the following 5 genes in uveal melanoma (UM): BAP1, EIF1AX, GNA11, GNAQ, and SF3B1. Understanding the prognostic significance of these mutations could facilitate their use in precision medicine. OBJECTIVE: To determine the associations between driver mutations, gene expression profile (GEP) classification, clinicopathologic features, and patient outcomes in UM. DESIGN, SETTING, AND PARTICIPANTS: Retrospective study of patients with UM treated by enucleation by a single ocular oncologist between November 1, 1998, and July 31, 2014...
July 1, 2016: JAMA Ophthalmology
https://www.readbyqxmd.com/read/27101414/vision-loss-following-episcleral-brachytherapy-for-uveal-melanoma-development-of-a-vision-prognostication-tool
#18
Hassan A Aziz, Nakul Singh, James Bena, Allan Wilkinson, Arun D Singh
IMPORTANCE: Vision loss following episcleral brachytherapy for uveal melanoma is difficult to predict for individual patients. OBJECTIVE: To generate a risk calculator for vision loss following episcleral brachytherapy for uveal melanoma. DESIGN, SETTING, AND PARTICIPANTS: A retrospective review of data was conducted at a multispecialty tertiary care center in Cleveland, Ohio. All patients with primary ciliary body or choroidal melanoma treated with iodine 125 or ruthenium 106 episcleral brachytherapy between January 1, 2004, and December 30, 2013, were included...
June 1, 2016: JAMA Ophthalmology
https://www.readbyqxmd.com/read/27084652/feasibility-of-proton-beam-therapy-for-ocular-melanoma-using-a-novel-3d-treatment-planning-technique
#19
William F Hartsell, Rashmi Kapur, Siobhan O'Connor Hartsell, Patrick Sweeney, Caitlin Lopes, Amanda Duggal, Jack Cohen, John Chang, Rajeev S Polasani, Megan Dunn, Mark Pankuch
PURPOSE: We evaluated sparing of normal structures using 3-dimensional (3D) treatment planning for proton therapy of ocular melanomas. METHODS AND MATERIALS: We evaluated 26 consecutive patients with choroidal melanomas on a prospective registry. Ophthalmologic work-up included fundoscopic photographs, fluorescein angiography, ultrasonographic evaluation of tumor dimensions, and magnetic resonance imaging of orbits. Three tantalum clips were placed as fiducial markers to confirm eye position for treatment...
May 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27083007/an-update-on-oculodermal-melanocytosis-and-rare-associated-conditions
#20
Andrea Maria Plateroti, Vittorio Scavella, Barmak Abdolrahimzadeh, Rocco Plateroti, Siavash Rahimi
Oculodermal melanocytosis (ODM) is a rare disease, which is characterized by hyperpigmentation of facial skin and several parts of the eye, such as the sclera, conjunctiva, cornea, iris, ciliary body, and choroid. The condition usually affects the Asian female population. The most typical presenting ocular sign is iris heterocromia. Iris hyperpigmentation may be associated with iris mammillations, which are dome-shaped protuberations of the iris surface. They are linked to a higher risk of malignant transformation when present in patients with ODM...
April 15, 2016: Seminars in Ophthalmology
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