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Vitreoretinal lymphoma

Chiara Mapelli, Alessandro Invernizzi, Giulio Barteselli, Marco Pellegrini, Elena Tabacchi, Giovanni Staurenghi, Francesco Viola
PURPOSE: To assess the characteristics and prevalence of fundus abnormalities in vitreoretinal lymphoma (VRL) using multimodal imaging. METHODS: We retrospectively reviewed chart and imaging studies of patients diagnosed with VRL. RESULTS: All 10 VRL patients (14 eyes) included in the study showed vitreitis, hyperreflective lesions on near-infrared reflectance imaging, and hypoautofluorescent lesions on fundus autofluorescence. Other findings included hypofluorescent lesions on fluorescein angiography (79%), hypocyanescent lesions on indocyanine green angiography (77%), small retinal pigment epithelium detachments (PEDs) (71%) and large PEDs (36%) on optical coherence tomography (OCT)...
September 15, 2016: Ophthalmologica. Journal International D'ophtalmologie
Katarzyna Kapelko-Slowik, Donata Urbaniak-Kujda, Anna Turno-Krecicka, Stanislaw Potoczek, Jaroslaw Dybko, Monika Biernat, Miroslaw Slowik
PURPOSE: Primary intraocular lymphoma (PIOL) is a rare malignancy with an aggressive clinical course. It is usually considered as a subset of primary central nervous system lymphoma. Differential diagnosis should include infectious and non-infectious aetiologies, particularly the common masqueraders sarcoidosis, tuberculosis, viral retinitis and syphilis. PATIENT: The article presents a case of bilateral vitreoretinal lymphoma manifesting as uveitis and vitritis resistant to corticosteroid therapy...
June 2016: Indian Journal of Hematology & Blood Transfusion
Masahiro Kitao, Noriyasu Hashida, Kohji Nishida
BACKGROUND: Primary vitreoretinal lymphoma (PVRL) is a rare and fatal ocular malignancy that is mostly classified as diffuse large B cell lymphoma (DLBCL). PVRL is often fatal because of its association with the central nervous system (CNS). PVRL frequently masquerades as uveitis and sometimes recurs in clinical findings as keratic precipitates (KPs) and subretinal lesions. Pseudohypopyon is one of the clinical findings of the local recurrence of PVRL and is treated with radiotherapy; however, the effectiveness of local control with an intravitreal injection of methotrexate (MTX) has not yet been determined...
2016: BMC Ophthalmology
Luca Cimino, Marco Coassin, Chi-Chao Chan, Sylvia Marchi, Matteo Belpoliti, Andrea Fanti, Alfonso Iovieno, Luigi Fontana
PURPOSE: To present challenging cases of vitreoretinal lymphoma (VRL) that was misdiagnosed as uveitis because of the apparent intraocular inflammation. At the light of the new classification of intraocular lymphomas, we detail the characteristics that masqueraded the tumors and the clinical aspects that guided us to the correct diagnosis. MATERIALS AND METHODS: We retrospectively reviewed the patients referred to our uveitis service between January 2006 and December 2014...
May 2016: Indian Journal of Ophthalmology
Teiko Saito, Nobuyuki Ohguro, Chiharu Iwahashi, Noriyasu Hashida
BACKGROUND: Primary vitreoretinal lymphoma (PVRL), a subset of primary central nervous system lymphoma (PCNSL), is a high-grade malignant tumor that shows various chorioretinal findings. Optical coherence tomography (OCT) is useful for detecting these lesions, and various abnormalities on OCT images have been reported. The purpose of this report was to investigate retrospectively the OCT manifestations of various disease stages and compare the manifestations of pretreatment, recurrent, and chronic cases...
June 1, 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
Matthew T Witmer
BACKGROUND: The prognosis for patients with primary vitreoretinal is dismal. The close association of primary vitreoretinal lymphoma with primary central nervous system lymphoma is responsible for high rates of mortality. Traditional treatments consist of systemic chemotherapy and whole-brain radiotherapy. The optimal approach for the treatment of isolated primary vitreoretinal lymphoma is unclear. METHODS: A review of the relevant medical and scientific literature was performed, focusing on the clinical features of primary vitreoretinal lymphoma and the progress made in the management of isolated ocular disease...
April 2016: Cancer Control: Journal of the Moffitt Cancer Center
Dimosthenis Mantopoulos, Colleen M Cebulla
PURPOSE: To correlate spectral domain optical coherence tomography (SD-OCT) and photographic imaging before and after spontaneous regression of primary vitreoretinal lymphoma (PVRL) lesions. PROCEDURES: We report the case of a 60-year-old female. RESULTS: The patient presented with bilateral creamy deposits under the retina and retinal pigment epithelium (RPE), and lesions were visible along Bruch's membrane with SD-OCT and suspicious for PVRL...
June 2015: Ocular Oncology and Pathology
Jared E Knickelbein, Jesia Hasan, Robert B Nussenblatt, H Nida Sen
PURPOSE: To investigate whether wide-field multispectral scanning laser ophthalmoscopy could assist in determining depth of chorioretinal pathology in posterior uveitis. METHODS: Cross-sectional retrospective review of patients with birdshot chorioretinopathy (BCR; 42 eyes of 21 patients) or active primary vitreoretinal lymphoma (PVRL; 18 eyes of 10 patients) who had multispectral wide-field scanning laser ophthalmoscopy (Optos) images. Images acquired with 532 nm and 635 nm lasers were analyzed separately using Optos V Vantage Pro Review software...
May 5, 2016: Retina
Falko Fend, Andrés J M Ferreri, Sarah E Coupland
The eye is a rare site for the development of malignant lymphoma. Based on cell type and involved intraocular structures, which as a whole represent an immune-privileged site, several subtypes of primary intraocular lymphoma need to be discerned. Primary vitreoretinal lymphoma (PVRL), the most common form, is an aggressive B-cell malignancy and considered a subtype of primary central nervous system (CNS) lymphoma. Ocular symptoms are non-specific and often mimic uveitis, frequently resulting in delayed diagnosis...
June 2016: British Journal of Haematology
Rumiko Taki, Atsunobu Takeda, Hiroshi Yoshikawa, Takako Fukuhara, Ryoichi Arita, Yoko Suehiro, Ilseung Choi, Yuji Kumano, Takao Nakamura, Tatsuro Ishibashi
PURPOSE: Systemic metastatic retinal lymphoma (SMRL) originates in systemic organs. It has been reported to exhibit clinical features similar to those of primary vitreoretinal lymphoma (PVRL). We report six cases of SMRL in a single-center survey in Japan. METHODS: The clinical and pathologic features in SMRL at the Kyushu University Hospital were retrospectively studied. RESULTS: The mean patient age at the onset of ocular involvement was 75...
April 12, 2016: Ocular Immunology and Inflammation
Sarakshi Mahajan, Raje Nijhawan, Aravind Rajwanshi, Samendra Karkhur, Samyak Mulkutar, Mohit Dogra, Vivek Lal, Vishali Gupta, Amod Gupta
PURPOSE: Primary vitreoretinal lymphomas (PVRL) pose a major diagnostic challenge, especially in the countries with a high prevalence of infectious variety of uveitis. The present study aims to report the clinical characteristics and diagnostic difficulties in patients with PVRL in an Indian Population. METHODS: Retrospective chart reviews of 12 patients with a diagnosis of PVRL. RESULTS: The study included 6 men and 6 women, with a mean age of 55...
March 22, 2016: Ocular Immunology and Inflammation
Florence Chaput, Radgonde Amer, Edoardo Baglivo, Valerie Touitou, Alexandra Kozyreff, Dominique Bron, Bahram Bodaghi, Phuc LeHoang, Chris Bergstrom, Hans E Grossniklaus, Chi-Chao Chan, Jacob Pe'er, Laure E Caspers
PURPOSE: To report on the clinical data of seven patients with T-cell intraocular lymphoma (IOL). METHODS: Retrospective case series. RESULTS: Seven immunocompetent patients, 12 eyes, 6 women, with T-cell-IOL were included from five countries. Mean age was 53.5 years (range: 25-82). Four patients had systemic-ocular lymphoma, two had CNS-ocular lymphoma, and one had systemic-CNS- ocular lymphoma. Vitritis was the most frequent clinical sign, followed by anterior uveitis and serous retinal detachment...
March 22, 2016: Ocular Immunology and Inflammation
Satoru Kase, Kenichi Namba, Daiju Iwata, Kazuomi Mizuuchi, Nobuyoshi Kitaichi, Yoshiaki Tagawa, Hiromi Okada-Kanno, Yoshihiro Matsuno, Susumu Ishida
BACKGROUND: Vitreoretinal lymphoma (VRL) is a life- and sight-threatening disorder. The aim of this study was to analyze the usefulness of the cell block method for diagnosis of VRL. METHODS: Sixteen eyes in 12 patients with VRL, and 4 eyes in 4 patients with idiopathic uveitis presenting with vitreous opacity were enrolled in this study. Both undiluted vitreous and diluted fluids were isolated during micro-incision vitrectomy. Cell block specimens were prepared in 19 eyes from diluted fluid containing shredding vitreous...
2016: Diagnostic Pathology
Harish Raja, Diva R Salomão, David S Viswanatha, Jose S Pulido
PURPOSE: Myeloid differentiation primary response gene 88 (MYD88) is a universal adaptor protein in the innate immune system. When associated with a proline for leucine substitution mutation at position 265 (L265P), the protein becomes constitutively activated, amplifying the intracellular pro-inflammatory signal. Recently, we reported two cases of vitreoretinal lymphoma (VRL) that were positive for the mutation. The purpose of this study was to determine prevalence of the MYD88 L265P mutation in a larger series of VRL...
March 2016: Retina
David Reichstein
PURPOSE OF REVIEW: Primary vitreoretinal lymphoma (PVRL) is a subset of primary central nervous system lymphoma in which disease primarily affects the uvea, retina, vitreous and optic nerve. This review discusses recent efforts to clarify the disease's pathogenesis, its diagnosis and its optimal treatment. RECENT FINDINGS: PVRL typically masquerades as a chronic intermediate uveitis in older individuals. Unambiguous diagnosis requires cytologic demonstration of malignant cells in a vitreous or chorioretinal specimen...
May 2016: Current Opinion in Ophthalmology
Martha E Ryan, Jessica G Shantha, Hans E Grossniklaus, Steven Yeh
Intraocular lymphoma is considered a uveitis masquerade syndrome and may rarely present with features resembling a necrotizing viral retinitis. The authors report a secondary vitreoretinal lymphoma presenting in this fashion, which was treated with a unique combination of intravitreal methotrexate and rituximab.
November 2015: Ophthalmic Surgery, Lasers & Imaging Retina
Atsunobu Takeda, Hiroshi Yoshikawa, Takako Fukuhara, Shin-Ichi Hikita, Kuniaki Hijioka, Takaaki Otomo, Ryoichi Arita, Toshio Hisatomi, Kazuhiro Kimura, Shigeo Yoshida, Yo-Ichi Kawano, Koh-Hei Sonoda, Tatsuro Ishibashi
PURPOSE: To determine the profiles of soluble cytokine receptors and cytokines, including mostly their ligands, in the vitreous humor of patients with B-cell vitreoretinal lymphoma (VRL) and uveitis. METHODS: Vitreous samples were collected from immunocompetent patients with VRL (n = 21), uveitis (n = 20), and idiopathic epiretinal membrane (n = 21) as controls. Cytometric beads assay were used to determine the vitreous concentrations of soluble receptors and cytokines...
November 2015: Investigative Ophthalmology & Visual Science
Ofira Zloto, Amir E Abd Elkader, Ido Didi Fabian, Vicktoria Vishnevskia-Dai
PURPOSE: To report a case of a patient with primary vitreoretinal lymphoma masquerading as retinitis. METHODS: Retrospective review of the patient's clinical, histopathological and imaging records. RESULTS: Cytopathology was negative for malignancy, and preliminary polymerase chain reaction results supported the diagnosis of varicella zoster virus retinitis. Therefore, the patient was treated with antiviral therapy. However, under this treatment, the retinitis progressed...
September 2015: Case Reports in Ophthalmology
Lauren B Patrick, Nimish A Mohile
Primary central nervous system lymphoma (PCNSL) is a rare form of non-Hodgkin lymphoma that is limited to the CNS. Although novel imaging techniques aid in discriminating lymphoma from other brain tumors, definitive diagnosis requires brain biopsy, vitreoretinal biopsy, or cerebrospinal fluid analysis. Survival rates in clinical studies have improved over the past 20 years due to the addition of high-dose methotrexate-based chemotherapy regimens to whole-brain radiotherapy. Long-term survival, however, is complicated by clinically devastating delayed neurotoxicity...
December 2015: Current Oncology Reports
Pradeep Venkatesh, Varun Gogia, Sumeet Khanduja, Shikha Gupta, Lalit Kumar, Satpal Garg
A 49-year-old female with biopsy proven primary vitreoretinal lymphoma and primary central nervous system lymphoma (PCNSL) presented with asymmetric involvement of both eyes. Right eye had primarily retinal and optic nerve involvement with no light perception while the left eye had purely vitreal form of the disease with visual acuity of 6/18. She was treated with recommended DeAngelis protocol for PCNSL and achieved complete remission of CNS disease and in the right eye and responded only partially to the systemic chemotherapy in the left eye...
July 2015: Journal of Cancer Research and Therapeutics
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