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Vitreoretinal lymphoma

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https://www.readbyqxmd.com/read/29145691/-primary-intraocular-lymphoma-relevance-of-diagnostic-vitrectomy
#1
Claudia Helga Le Guin, Klaus Metz, Norbert Bornfeld
Primary intraocular lymphomas are rare tumours that can be further subdivided into primary vitreoretinal and the even rarer primary uveal lymphoma. The incidence of primary vitreoretinal lymphoma (PVRL) has increased during the last few decades. Differential diagnostic distinction between lymphoma and posterior uveitis is often difficult, so that adequate diagnosis and treatment is often delayed. This is fatal, because PVRL is often associated with primary central nervous lymphoma. To confirm the diagnosis, prior treatment of cytological or histological detection of lymphoma cells is the gold standard...
November 16, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29135797/use-of-a-threshold-of-interleukin-10-and-il-10-il-6-ratio-in-ocular-samples-for-the-screening-of-vitreoretinal-lymphoma
#2
Celine Pochat-Cotilloux, Jacques Bienvenu, Anh-Minh Nguyen, Robin Ohanessian, Hervé Ghesquières, Pascal Sève, Lorna Garnier, Laurent Kodjikian
PURPOSE: To determine a threshold for interleukin (IL)-10 and IL-10/IL-6 ratio in the aqueous humor (AH) and the vitreous for the screening of vitreoretinal lymphoma (VRL). METHODS: One hundred nineteen patients for whom IL-10 and IL-6 in the AH and/or vitreous had been measured were included: 16 patients with a final diagnosis of VRL and 103 patients with final diagnosis of uveitis. Groups were compared according to IL-10 and IL-6 levels and demographic data. RESULTS: In patients with VRL (Group 1), mean IL-10 values were 5,636 pg/mL, and in patients with uveitis (Group 2), 6...
November 10, 2017: Retina
https://www.readbyqxmd.com/read/29123243/immunohistochemical-detection-of-propionibacterium-acnes-in-the-retinal-granulomas-in-patients-with-ocular-sarcoidosis
#3
Kenji Nagata, Yoshinobu Eishi, Keisuke Uchida, Kazuhito Yoneda, Hiroki Hatanaka, Toru Yasuhara, Maho Nagata, Chie Sotozono, Shigeru Kinoshita
The etiology of sarcoidosis is still obscure; however, Mycobacteria and Propionibacterium acnes are considered the most implicated etiological agent for sarcoidosis. To investigate whether P. acnes is an etiological agent for sarcoid uveitis, we analyzed the frequency of P. acnes detected within the biopsied retinas from patients with ocular sarcoidosis by immunohistochemistry with a P. acnes-specific monoclonal antibody (PAB antibody). Eleven patients (12 eyes) with sarcoid uveitis were enrolled in this study...
November 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28993856/-malignant-lymphomas-of-the-eye
#4
REVIEW
F Fend, D Süsskind, C Deuter, S E Coupland
The eye and the ocular adnexae are rare sites for malignant non-Hodgkin lymphoma (NHL). Based on their anatomical location, intraocular lymphomas must be discerned from NHL of adnexal structures including conjunctiva, lacrimal gland, and orbit. Whereas the latter group mostly consists of indolent extranodal marginal zone B‑cell lymphomas of mucosa-associated lymphoid tissue (MALT) type or secondary manifestations of systemic NHL, most primary intraocular lymphomas are classified as diffuse large B‑cell lymphomas (DLBCL) and are considered a variant of primary DLBCL of the central nervous system...
November 2017: Der Pathologe
https://www.readbyqxmd.com/read/28973119/optic-nerve-infiltration-in-primary-central-nervous-system-lymphoma
#5
Guido Ahle, Valérie Touitou, Nathalie Cassoux, Marie Bouyon, Catherine Humbrecht, Hélène Oesterlé, Alexander Baraniskin, Carole Soussain, Ludovic Nguyen-Them, Claude Gaultier, Khê Hoang-Xuan, Caroline Houillier
Importance: Visual impairment in primary central nervous system lymphoma (PCNSL) is caused mostly by intraocular lymphomatous involvement (vitritis and retinal infiltration), whereas optic nerve infiltration (ONI) is a rare condition. Objective: To describe the clinical presentation of ONI, its imaging characteristics, and outcome. Design, Setting and Participants: A total of 752 patients diagnosed with PCNSL were retrospectively identified from the databases of 3 French hospitals from January 1, 1998, through December 31, 2014...
November 1, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28880986/association-of-disease-location-and-treatment-with-survival-in-diffuse-large-b-cell-lymphoma-of-the-eye-and-ocular-adnexal-region
#6
Aseef H Ahmed, C Stephen Foster, Carol L Shields
Importance: Primary diffuse large B-cell lymphoma (DLBCL) of the ocular region is rare, and the utility of surgery and radiation therapy remains unresolved. Objective: To explore the clinical characteristics and determine factors associated with overall survival in primary vitreoretinal lymphoma (PVRL) and ocular adnexal (OA)-uveal DLBCL. Design, Setting, and Participants: This retrospective analysis included 396 patients with ophthalmic DLBCL from January 1, 1973, through December 31, 2014, using the Surveillance, Epidemiology, and End Results database...
October 1, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28617918/intravitreal-melphalan-for-treatment-of-primary-vitreoretinal-lymphoma-a-new-indication-for-an-old-drug
#7
Carol L Shields, Kareem Sioufi, Arman Mashayekhi, Jerry A Shields
No abstract text is available yet for this article.
July 1, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28558176/primary-vitreoretinal-lymphoma-a-review
#8
REVIEW
Iguaracyra Araujo, Sarah E Coupland
Primary vitreoretinal lymphoma (PVRL) is the most common intraocular lymphoma occurring in the eye. It is a high-grade typically B-cell malignancy, arising in the retina, and is often associated with central nervous system (CNS) disease and thereby a poor prognosis. It needs to be distinguished from choroidal low-grade B-cell lymphomas, which do not disseminate to the brain and have a good prognosis. Because of the rarity of PVRL, information is lacking regarding its true incidence, its geographical or ethnic variation, and underlying risk factors apart from immunosuppression associated with human immunodeficiency virus (HIV) and Epstein Barr virus...
May 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28451463/macular-edema-is-a-rare-finding-in-untreated-vitreoretinal-lymphoma-small-case-series-and-review-of-the-literature
#9
REVIEW
Elisa Carreras, Diva R Salomão, Jeroni Nadal, Sejal R Amin, Harish Raja, Thomas J Grube, Ryan L Geraets, Patrick B Johnston, Brian P O'Neill, Jose S Pulido
BACKGROUND: To determine the occurrence of macular edema (ME) in vitreoretinal lymphoma (VRL). METHODS: Retrospective analysis of 17 patients (31 eyes) with VRL. A review of the literature was done as well. RESULTS: Nine patients (15 eyes) had fluorescein angiography and/or optical coherence tomography at presentation. In the ME group (six eyes of four patients), three patients (five eyes) had prior chemotherapy and radiation. Excluding eyes with radiation retinopathy (three eyes), rate of ME was 25% (3/12)...
2017: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/28419996/polydimethyl-siloxane-as-an-internal-tamponade-for-vitreoretinal-surgery
#10
Rumana N Hussain, Jayavani Myneni, Theodor Stappler, David Wong
PURPOSE: To report the efficacy and safety of polydimethyl siloxane (Siluron Xtra®) as an internal tamponade. DESIGN: Audit and adverse event screening of procedures (March 2014-2015). METHODS: Patients who had undergone vitreoretinal procedures with Siluron Xtra® tamponade were retrospectively analysed with respect to anatomical outcome, visual outcomes, and perioperative complications, in particular intraocular pressure. INCLUSION CRITERIA: all patients who had undergone Siluron Xtra® tamponade...
2017: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/28359629/-multimodal-imaging-in-primary-intraocular-lymphoma
#11
S Santos, M L Le Lez, S Arsène, P J Pisella
INTRODUCTION: Vitreoretinal lymphoma is a serious disease with highly varied clinical presentations. The goal of this work is to identify the various presentations (clinical, imaging) in order to improve screening for this disease. MATERIALS AND METHOD: We collected data of patients followed on our service for vitreoretinal lymphoma. The fundus exam, autofluorescence and angiography data were classified in order to identify signs, which might lead to earlier diagnosis of lymphoma...
April 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28273192/-primary-central-nervous-system-lymphoma-pathogenesis-and-histomorphology
#12
Gábor Méhes
Lymphoproliferative diseases of the central nervous system are rare, diagnostics and treatment are accordingly challenging. Since the introduction of the 2008 WHO lymphoma classification, primary CNS DLBCL - also covering the associated primary ocular (vitreoretinal) lymphoma - is a separate entity. The special localization is related with a series of newly recognized genetic, genomic and immunologic features directing to the strong interaction between transformed lymphoma cells, neural tissue components and the local immune response...
March 8, 2017: Magyar Onkologia
https://www.readbyqxmd.com/read/28128370/an-ocular-protein-triad-can-classify-four-complex-retinal-diseases
#13
J J W Kuiper, L Beretta, S Nierkens, R van Leeuwen, N H Ten Dam-van Loon, J Ossewaarde-van Norel, M C Bartels, J D F de Groot-Mijnes, P Schellekens, J H de Boer, T R D J Radstake
Retinal diseases generally are vision-threatening conditions that warrant appropriate clinical decision-making which currently solely dependents upon extensive clinical screening by specialized ophthalmologists. In the era where molecular assessment has improved dramatically, we aimed at the identification of biomarkers in 175 ocular fluids to classify four archetypical ocular conditions affecting the retina (age-related macular degeneration, idiopathic non-infectious uveitis, primary vitreoretinal lymphoma, and rhegmatogenous retinal detachment) with one single test...
January 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28039672/two-cases-of-primary-vitreoretinal-lymphoma-a-diagnostic-challenge-the-supporting-role-of-multimodal-imaging-in-the-diagnosis-of-primary-vitreoretinal-lymphoma
#14
Mariachiara Morara, Federico Foschi, Chiara Veronese, Carlo Torrazza, Francesco Bacci, Vittorio Stefoni, P Antonio Ciardella
PURPOSE: To report two cases of primary vitreoretinal lymphoma (PVRL), which presented as intermediate and posterior uveitis. METHODS: Combined clinical assessment, multimodal imaging with spectral-domain optical coherence tomography, fundus autofluorescence, fluorescein angiography, indocyanine green angiography, brain magnetic resonance imaging and vitreous and retinal biopsy. Case 1 was a 48-year-old woman who complained of visual loss in her right eye secondary to a diffuse vitreous opacification and multiple chorioretinal lesions...
December 30, 2016: International Ophthalmology
https://www.readbyqxmd.com/read/28002793/next-generation-sequencing-of-vitreoretinal-lymphomas-from-small-volume-intraocular-liquid-biopsies-new-routes-to-targeted-therapies
#15
Andi K Cani, Daniel H Hovelson, Hakan Demirci, Mark W Johnson, Scott A Tomlins, Rajesh C Rao
BACKGROUND: Vitreoretinal lymphoma (VRL), the most common lymphoma of the eye, is a rare form of primary CNS lymphoma (PCNSL). Most frequently a high-grade diffuse large B cell lymphoma, VRL can cause vision loss and its prognosis remains dismal: the overall survival time is 3 years after diagnosis. Radiotherapy and chemotherapy are used but remain frequently ineffective, and no standardized treatment regimen exists. Furthermore, no biologically targeted treatments, based on the genetic profile of the tumor, are available, as VRL has hitherto not comprehensively been profiled...
January 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/27843904/histopathologic-diagnosis-of-atypical-primary-vitreoretinal-lymphoma-following-enucleation
#16
Arjun B Sood, Steven Yeh, Pia Mendoza, Hans E Grossniklaus
INTRODUCTION: Primary vitreoretinal lymphoma (PVRL) is a rare but potentially fatal malignancy. The diagnosis of PVRL remains challenging. Here, we present a case of PVRL with a diagnostic enucleation required to establish the diagnosis. METHODS/CASE DESCRIPTION: A 58-year-old otherwise healthy woman was referred for evaluation of panuveitis with persistent blurred vision in the left eye. Extensive laboratory work-up was negative. On initial evaluation, the patient had visual acuity of no light perception in the left eye...
October 2016: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/27627063/multimodal-imaging-of-vitreoretinal-lymphoma
#17
Chiara Mapelli, Alessandro Invernizzi, Giulio Barteselli, Marco Pellegrini, Elena Tabacchi, Giovanni Staurenghi, Francesco Viola
PURPOSE: To assess the characteristics and prevalence of fundus abnormalities in vitreoretinal lymphoma (VRL) using multimodal imaging. METHODS: We retrospectively reviewed chart and imaging studies of patients diagnosed with VRL. RESULTS: All 10 VRL patients (14 eyes) included in the study showed vitreitis, hyperreflective lesions on near-infrared reflectance imaging, and hypoautofluorescent lesions on fundus autofluorescence. Other findings included hypofluorescent lesions on fluorescein angiography (79%), hypocyanescent lesions on indocyanine green angiography (77%), small retinal pigment epithelium detachments (PEDs) (71%) and large PEDs (36%) on optical coherence tomography (OCT)...
2016: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/27408377/primary-intraocular-diffuse-large-b-cell-lymphoma-diagnostic-difficulties-in-deep-retinal-infiltrations-with-vitritis
#18
Katarzyna Kapelko-Slowik, Donata Urbaniak-Kujda, Anna Turno-Krecicka, Stanislaw Potoczek, Jaroslaw Dybko, Monika Biernat, Miroslaw Slowik
PURPOSE: Primary intraocular lymphoma (PIOL) is a rare malignancy with an aggressive clinical course. It is usually considered as a subset of primary central nervous system lymphoma. Differential diagnosis should include infectious and non-infectious aetiologies, particularly the common masqueraders sarcoidosis, tuberculosis, viral retinitis and syphilis. PATIENT: The article presents a case of bilateral vitreoretinal lymphoma manifesting as uveitis and vitritis resistant to corticosteroid therapy...
June 2016: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/27391815/recurrent-pseudohypopyon-in-association-with-primary-vitreoretinal-lymphoma-a-case-report
#19
Masahiro Kitao, Noriyasu Hashida, Kohji Nishida
BACKGROUND: Primary vitreoretinal lymphoma (PVRL) is a rare and fatal ocular malignancy that is mostly classified as diffuse large B cell lymphoma (DLBCL). PVRL is often fatal because of its association with the central nervous system (CNS). PVRL frequently masquerades as uveitis and sometimes recurs in clinical findings as keratic precipitates (KPs) and subretinal lesions. Pseudohypopyon is one of the clinical findings of the local recurrence of PVRL and is treated with radiotherapy; however, the effectiveness of local control with an intravitreal injection of methotrexate (MTX) has not yet been determined...
July 8, 2016: BMC Ophthalmology
https://www.readbyqxmd.com/read/27380976/vitreoretinal-lymphomas-misdiagnosed-as-uveitis-lessons-learned-from-a-case-series
#20
Luca Cimino, Marco Coassin, Chi-Chao Chan, Sylvia Marchi, Matteo Belpoliti, Andrea Fanti, Alfonso Iovieno, Luigi Fontana
PURPOSE: To present challenging cases of vitreoretinal lymphoma (VRL) that was misdiagnosed as uveitis because of the apparent intraocular inflammation. At the light of the new classification of intraocular lymphomas, we detail the characteristics that masqueraded the tumors and the clinical aspects that guided us to the correct diagnosis. MATERIALS AND METHODS: We retrospectively reviewed the patients referred to our uveitis service between January 2006 and December 2014...
May 2016: Indian Journal of Ophthalmology
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