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https://www.readbyqxmd.com/read/27906424/s100b-in-serum-and-saliva-a-valid-invasive-or-non-invasive-biomarker-in-obstructive-sleep-apnea
#1
M Traxdorf, O Wendler, K Tziridis, J Bauer, C Scherl
OBJECTIVE:   The aim of this prospective study was to determine whether serum or saliva S100B could be established as an invasive or non-invasive biomarker of cerebrovascular stress due to chronic intermittent hypoxia in obstructive sleep apnea (OSA). PATIENTS AND METHODS: S100B levels in serum and saliva were measured by an enzyme-linked immunosorbent assay (ELISA) in 40 patients with polysomnographically confirmed OSA (n=34) or ronchopathy (n=6) and 20 control subjects (n=20)...
November 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27905825/saliva-volatile-biomarkers-and-profiles
#2
Maciej Milanowski, Paweł Pomastowski, Tomasz Ligor, Bogusław Buszewski
Saliva is an aqueous fluid found in the oral cavity playing fundamental role in the preservation and maintenance of oral health. Apart from higher-molecular-weight constituents it contains volatile organic compounds (VOCs) that may origin from such sources as blood or be result of bacterial metabolism. They can also reach the oral fluid through dissolving of volatiles from breath and consumed foods. Some of them may serve as biomarkers of various diseases, such as dimethyl disulfide (halitosis), pyridine (periodontal disease) and trimethylamine (trimethylaminuria) or occupational exposure...
December 1, 2016: Critical Reviews in Analytical Chemistry
https://www.readbyqxmd.com/read/27903845/protein-biomarkers-of-mood-disorders
#3
EDITORIAL
Carmen Rodríguez Cerdeira, Elena Sánchez-Blanco, Beatriz Sánchez-Blanco, Jose Luis González-Cespón
Psychiatric evaluation presents a significant challenge because it conceptually integrates the input from multiple psychopathological approaches. Recent technological advances in the study of protein structure, function, and interactions have provided a breakthrough in the diagnosis and treatment of mood disorders (MD), and have identified novel biomarkers to be used as indicators of normal and disease states or response to drug treatment. The investigation of biomarkers for psychiatric disorders, such as enzymes (catechol-O-methyl transferase and monoamine oxidases) or neurotransmitters (dopamine, serotonin, norepinephrine) and their receptors, particularly their involvement in neuroendocrine activity, brain structure, and function, and response to psychotropic drugs, should facilitate the diagnosis of MD...
November 30, 2016: International Journal of Immunopathology and Pharmacology
https://www.readbyqxmd.com/read/27903834/saliva-diagnostics-current-views-and-directions
#4
Karolina Elżbieta Kaczor-Urbanowicz, Carmen Martin Carreras-Presas, Katri Aro, Michael Tu, Franklin Garcia-Godoy, David Tw Wong
In this review, we provide an update on the current and future applications of saliva for diagnostic purposes. There are many advantages of using saliva as a biofluid. Its collection is fast, easy, inexpensive, and non-invasive. In addition, saliva, as a "mirror of the body," can reflect the physiological and pathological state of the body. Therefore, it serves as a diagnostic and monitoring tool in many fields of science such as medicine, dentistry, and pharmacotherapy. Introduced in 2008, the term "Salivaomics" aimed to highlight the rapid development of knowledge about various "omics" constituents of saliva, including: proteome, transcriptome, micro-RNA, metabolome, and microbiome...
November 29, 2016: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/27903041/general-practitioners-knowledge-and-management-of-dry-mouth-a-qualitative-study
#5
Natalie J Appleby, Meredith J Temple-Smith, Margaret A Stacey, Denise L Bailey, Elizabeth M Deveny, Marie Pirotta
BACKGROUND: Dry mouth (xerostomia) is common and can have significant consequences for a patient's general and oral health. Multiple medications may compromise the flow and quality of saliva. OBJECTIVE: This study explored general practitioners' (GPs') perceptions, knowledge and management of dry mouth, and whether consideration of oral health influences prescribing patterns. METHODS: Semi-structured interviews with 20 GPs in Melbourne, Victoria, were audiotaped, transcribed and analysed...
December 2016: Australian Family Physician
https://www.readbyqxmd.com/read/27902816/association-of-filaggrin-loss-of-function-and-thymic-stromal-lymphopoietin-variation-with-treatment-use-in-pediatric-atopic-dermatitis
#6
Joshua Chang, Nandita Mitra, Ole Hoffstad, David J Margolis
Importance: Atopic dermatitis (AD) is a common illness of childhood. Objective: To determine whether variations in FLG and TSLP genotype corresponded to differences in treatment use over time. Design, Setting, and Participants: This prospective cohort study recruited and followed a volunteer sample of 842 children enrolled in the Pediatric Eczema Elective Registry who provided saliva samples for DNA extraction for 10 years. Eligibility criteria included age 2 to 17 years, AD diagnosis without cancer, and prior pimecrolimus use...
November 30, 2016: JAMA Dermatology
https://www.readbyqxmd.com/read/27902590/genotypic-distribution-of-hhv-8-in-aids-individuals-without-and-with-kaposi-sarcoma-is-genotype-b-associated-with-better-prognosis-of-aids-ks
#7
Tania Regina Tozetto-Mendoza, Karim Yaqub Ibrahim, Adriana Fumie Tateno, Cristiane Mendes de Oliveira, Laura Massami Sumita, Maria Carmem Arroyo Sanchez, Expedito José Luna, Ligia Camara Pierrotti, Jan Felix Drexler, Paulo Henrique Braz-Silva, Claudio Sérgio Pannuti, Camila Malta Romano
AIDS-associated Kaposi's sarcoma (AIDS-KS) caused by human herpes virus 8 (HHV-8) is the most severe and resistant form of KS tumor. Our aim was to verify whether there is an association between HHV-8 variability and development of AIDS-KS in Brazil by comparing the HHV-8 variability between individuals without and with KS. Saliva samples and blood, when available, were analyzed by polymerase chain reaction (PCR) techniques for detection of the fragments of ORF K1 of HHV-8, which were then genotyped and analyzed regarding the genetic variability...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27901320/salivary-dna-methylation-profiling-aspects-to-consider-for-biomarker-identification
#8
Sabine A S Langie, Matthieu Moisse, Ken Declerck, Gudrun Koppen, Lode Godderis, Wim Vanden Berghe, Stacy Drury, Patrick De Boever
Is it not more comfortable to spit saliva in a tube than to be pricked with a needle to draw blood to analyse your health and disease risk? A lot of patients, study participants and (parents of) young children undoubtedly prefer non-invasive and convenient procedures. Such procedures increase compliance rates especially for longitudinal prospective studies. Saliva is an attractive biofluid providing good quality DNA to study epigenetic mechanisms underlying disease across development. In this MiniReview, we will describe the different applications of saliva in the field of epigenetics, focusing on genome-wide methylation analysis...
November 30, 2016: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/27901227/evaluation-of-cytotoxicity-and-corrosion-resistance-of-orthodontic-mini-implants
#9
Celha Borges Costa Alves, Márcio Nunes Segurado, Miriam Cristina Leandro Dorta, Fátima Ribeiro Dias, Maurício Guilherme Lenza, Marcos Augusto Lenza
Objective: To evaluate and compare in vitro cytotoxicity and corrosion resistance of mini-implants from three different commercial brands used for orthodontic anchorage. Methods: Six mini-implants (Conexão(tm), Neodent(tm) and SIN(tm)) were separately immersed in artificial saliva (pH 6.76) for 30 and 60 days. The cytotoxicity of the corrosion extracts was assessed in L929 cell cultures using the violet crystal and MTT assays, as well as cell morphology under light microscopy...
September 2016: Dental Press Journal of Orthodontics
https://www.readbyqxmd.com/read/27901184/evaluation-of-salivary-oxidative-parameters-in-overweight-and-obese-young-adults
#10
Eduardo Ottobelli Chielle, Jeferson Noslen Casarin
Background: Obesity is characterized by a deposition of abnormal or excessive fat in adipose tissue, and is linked with a risk of damage to several metabolic and pathological processes associated with oxidative stress. To date, salivary oxidative biomarkers have been minimally explored in obese individuals. Thus, the aim of this study was to assess the concentrations of salivary oxidative biomarkers (ferric-reducing antioxidant power, uric acid, sulfhydryl groups) and lipid peroxidation in obese and overweight young subjects...
November 24, 2016: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27900324/low-expression-of-angiotensinogen-and-dipeptidyl-peptidase-1-in-saliva-of-patients-with-proliferative-verrucous-leukoplakia
#11
Isadora Luana Flores, Alan Roger Santos-Silva, Ricardo Della Coletta, Adriana Franco Paes Leme, Marcio Ajudarte Lopes
AIM: To elucidate the profile of the salivary proteome. METHODS: Unstimulated whole mouth saliva was collected from 30 volunteers [15 proliferative verrucous leukoplakia (PVL) patients and 15 controls] and proteins were submitted for mass spectrometry-based proteomics using the discovery approach, followed by analyses of variance and logistic regression tests. RESULTS: A total of two hundred and eighty-three proteins were confidently identified in saliva...
November 16, 2016: World Journal of Clinical Cases
https://www.readbyqxmd.com/read/27900251/salivary-biomarkers-in-oral-squamous-cell-carcinoma-an-insight
#12
REVIEW
T Radhika, Nadeem Jeddy, S Nithya, R M Muthumeenakshi
Oral cancer refers to the malignancies that occur in the oral cavity, lip and pharynx with 90% of oral cancers being squamous cell carcinomas (OSCC). OSCC has the highest mortality ratio compared to other carcinomas. Although oral cavity is easily accessible, most oral cancers are detected at a later stage leading to lower survival rates. Early detection of OSCC is a key factor in improving the prognosis and survival rate of the patient. Rapid advancement in the field of diagnosis has enabled early diagnosis of many potentially malignant conditions even before its clinical manifestations...
November 2016: Journal of Oral Biology and Craniofacial Research
https://www.readbyqxmd.com/read/27900250/effect-of-tens-on-stimulation-of-saliva-in-postmenopausal-women-with-or-without-oral-dryness-an-interventional-study
#13
Aravinda Konidena, Dheeraj Sharma, Gagan Puri, Avani Dixit, Deepa Jatti, Rajesh Gupta
BACKGROUND: Decreased estrogen levels in postmenopausal women may cause an increase in oral symptoms including dry mouth, burning sensation of the mouth, and taste alterations. Management of salivary gland hypofunction by various modalities had been tried with variable results and associated side effects or discomfort. AIM: To evaluate the effects of transcutaneous electric nerve stimulation (TENS) on whole salivary flow rate in postmenopausal females with and without oral dryness...
November 2016: Journal of Oral Biology and Craniofacial Research
https://www.readbyqxmd.com/read/27900249/the-influence-of-smoking-on-the-levels-of-matrix-metalloproteinase-8-and-periodontal-parameters-in-smoker-and-nonsmoker-patients-with-chronic-periodontitis-a-clinicobiochemical-study
#14
Namita Gupta, Narinder Dev Gupta, Lata Goyal, Shagufta Moin, Saif Khan, Akash Gupta, Sagar Garg
AIMS: Even though worldwide evidences tend to prove that smoking adversely influences periodontal health, there are few studies demonstrating the effect of levels of salivary matrix metalloproteinase-8 (MMP-8) in smokers. This study aimed to compare and quantify the levels of MMP-8 in smokers and also to evaluate the effect of smoking on periodontal indices in smokers and nonsmokers with chronic periodontitis. METHODS: A total number of 60 subjects were selected for the study and were divided into three groups: group I, healthy nonsmoking subjects; group II, nonsmoking patients with chronic periodontitis; group III, smoking patients with chronic periodontitis...
November 2016: Journal of Oral Biology and Craniofacial Research
https://www.readbyqxmd.com/read/27900246/siga-peroxidase-and-collagenase-in-saliva-of-smokers-aggressive-periodontal-patients
#15
Myriam A Koss, Cecilia E Castro, Agustina M Gramajo, María E López
BACKGROUND: Tobacco smoking is strongly associated with destructive periodontal disease, alveolar bone loss and poor response to periodontal therapy. The aim of this study was to investigate the effect of smoking on antimicrobials and destructive proteins in the saliva of patients with generalized aggressive periodontal disease. MATERIAL AND METHODS: The study group consisted of 55 adult subjects. They were classified according to their clinical diagnoses either as having generalized aggressive periodontitis (n = 27; 13 smokers and 14 non-smokers) or as periodontitis-free control group (n = 28; 14 smokers and 14 non-smokers)...
November 2016: Journal of Oral Biology and Craniofacial Research
https://www.readbyqxmd.com/read/27900241/changes-in-the-salivary-oxidative-status-in-individuals-with-temporomandibular-disorders-and-pain
#16
Claudyane de Almeida, José Miguel Amenábar
Temporomandibular joint disorders are quite common among the general public. Free radicals may play a role in the pathogenesis of joint diseases, and the oxidative stress is an important aspect in the mechanism of TMDs. The use of new biotechnologies has enabled the use of saliva as a diagnostic method. This is the first paper that aims to investigate changes in the oxidative status, through saliva analysis, in individuals who suffer from temporomandibular disorder and pain. Sixty individuals, 54 women and 06 men, aged between 10 and 60, participated in this research...
November 2016: Journal of Oral Biology and Craniofacial Research
https://www.readbyqxmd.com/read/27898671/prevalence-of-cutaneous-leishmaniasis-in-districts-of-high-and-low-endemicity-in-mali
#17
Bourama Traoré, Fabiano Oliveira, Ousmane Faye, Adama Dicko, Cheick A Coulibaly, Ibrahim M Sissoko, Samake Sibiry, Nafomon Sogoba, Moussa Brema Sangare, Yaya I Coulibaly, Pierre Traore, Sekou F Traore, Jennifer M Anderson, Somita Keita, Jesus G Valenzuela, Shaden Kamhawi, Seydou Doumbia
Historically the western sahelian dry regions of Mali are known to be highly endemic for cutaneous leishmaniasis (CL) caused by Leishmania major, while cases are rarely reported from the Southern savanna forest of the country. Here, we report baseline prevalence of CL infection in 3 ecologically distinct districts of Mali (dry sahelian, north savanna and southern savanna forest areas). We screened 195 to 250 subjects from 50 to 60 randomly selected households in each of the 6 villages (four from the western sahelian district of Diema in Kayes region, one from the central district of Kolokani and one from the southern savanna district of Kolodieba, region of Sikasso)...
November 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27898397/multicenter-performance-evaluation-of-a-second-generation-cortisol-assay
#18
Michael Vogeser, Jürgen Kratzsch, Yoon Ju Bae, Mathias Bruegel, Uta Ceglarek, Tom Fiers, Alexander Gaudl, Hedwig Kurka, Christoph Milczynski, Cristina Prat Knoll, Anna C Suhr, Daniel Teupser, Ingrid Zahn, Richard E Ostlund
BACKGROUND: Untreated disorders of the adrenocortical system, such as Cushing's or Addison's disease, can be fatal, and accurate quantification of a patient's cortisol levels is vital for diagnosis. The objective of this study was to assess the analytical performance of a new fully-automated Elecsys® Cortisol II assay (second generation) to measure cortisol levels in serum and saliva. METHODS: Four European investigational sites assessed the intermediate precision and reproducibility of the Cortisol II assay (Roche Diagnostics) under routine conditions...
November 29, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/27898189/salivary-biomarkers-as-tools-for-oral-squamous-cell-carcinoma-diagnosis-a-systematic-review
#19
REVIEW
Vitor T Stuani, Cassia M F Rubira, Adriana C P Sant'Ana, Paulo S S Santos
BACKGROUND: The oral squamous cell carcinoma (OSCC) survival rate is influenced by the fact that diagnoses occur mostly in late stages of the disease. Thus, there is a clear contribution in the early findings, making the use of minimally invasive techniques for diagnosis, such as analysis of salivary markers, interesting tools. METHODS: A systematic review was performed with all studies that establish a comparison between the levels of saliva-based markers found in patients with OSCC compared with cancer-free individuals...
November 29, 2016: Head & Neck
https://www.readbyqxmd.com/read/27898021/salivary-microbiome-diversity-in-caries-free-and-caries-affected-children
#20
Shan Jiang, Xiaoli Gao, Lijian Jin, Edward C M Lo
Dental caries (tooth decay) is an infectious disease. Its etiology is not fully understood from the microbiological perspective. This study characterizes the diversity of microbial flora in the saliva of children with and without dental caries. Children (3-4 years old) with caries (n = 20) and without caries (n = 20) were recruited. Unstimulated saliva (2 mL) was collected from each child and the total microbial genomic DNA was extracted. DNA amplicons of the V3-V4 hypervariable region of the bacterial 16S rRNA gene were generated and subjected to Illumina Miseq sequencing...
November 25, 2016: International Journal of Molecular Sciences
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