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https://www.readbyqxmd.com/read/28099585/impact-of-different-normality-thresholds-for-24-hour-abpm-at-the-primary-health-care-level
#1
Guilherme Brasil Grezzana, David William Moraes, Airton Tetelbon Stein, Lucia Campos Pellanda
Background: Hypertension is an important risk factor for cardiovascular outcomes. Primary health care (PHC) physicians should be prepared to act appropriately in the prevention of cardiovascular risk factors. However, the rates of patients with control of blood pressure (BP) remain low. The impact of the reclassification of high BP by 24-hour ambulatory BP monitoring (ABPM) can lead to different medical decisions in PHC. Objective: To evaluate the agreement between the BP measured by a conventional method by PHC physicians and by 24-hour ABPM, considering different BP normal thresholds for the 24-hour ABPM according to the V Brazilian ABPM Guidelines and the European Society of Hypertension Guidelines...
January 16, 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28074610/an-in%C3%A2-vitro-model-yields-importin-new-insights-into-chronic-traumatic-encephalopathy-damaged-astrocytes-stop-thrombospondin-to-the-injury-an-editorial-highlight-for-defective-synthesis-and-release-of-astrocytic-thrombospondin-1-mediates-the-neuronal-tdp-43
#2
EDITORIAL
Sausan M Jaber, Brian M Polster
Read the highlighted article 'Defective synthesis and release of astrocytic thrombospondin-1 mediates the neuronal TDP-43 proteinopathy, resulting in defects in neuronal integrity associated with chronic traumatic encephalopathy: in vitro studies' on doi: 10.1111/jnc.13867.
January 10, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28070471/importance-of-mean-red-cell-distribution-width-in-hypertensive-patients
#3
Ahmed Bilal, Junaid H Farooq, Immad Kiani, Salman Assad, Haider Ghazanfar, Imran Ahmed
PURPOSE: Red cell distribution width (RDW), expressed in femtoliters (fl), is a measure of the variation in the size of circulating erythrocytes and is often expressed as a direct measurement of the width of the distribution. We aim to observe the mean value of red cell distribution width (RDW) in hypertensive patients. Increased RDW can be used as a tool for early diagnosis, as an inflammatory marker, and a mortality indicator in hypertensive patients due to its close relation to inflammation...
November 29, 2016: Curēus
https://www.readbyqxmd.com/read/28058727/exppning-how-acetylcholine-improves-gait-in-parkinson-s-disease-an-editorial-highlight-for-deletion-of-the-vesicular-acetylcholine-transporter-from-pedunculopontine-laterodorsal-tegmental-neurons-modifies-gait
#4
EDITORIAL
Björn Falkenburger
Gait impairment is one of the most intractable symptoms of Parkinson's disease, responding poorly to dopaminergic medication. Promising therapeutic strategies include deep brain stimulation (DBS) of the pedunculopontine nucleus (PPN) and enhancing cholinergic neurotransmission by acetylcholine esterase inhibitors. This Editorial discusses an elegant study by Janickova and coworkers in the current issue of the Journal of Neurochemistry, in which the authors engineered mice lacking cholinergic transmission selectively in the PPN and demonstrate that cholinergic neurons of the PPN are critical for gait...
January 6, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28033742/assessment-of-achieved-systolic-blood-pressure-in-newly-treated-hypertensive-patients-aged-60-79-years-before-and-after-eighth-joint-national-committee-recommendations
#5
Michael S Kelly, Joseph J Saseen, Joel C Marrs
OBJECTIVE: To determine whether patients who were newly prescribed antihypertensive therapy after the Eighth Joint National Committee (JNC 8) update were treated to a relaxed systolic blood pressure (SBP) goal compared with patients treated before the update. METHODS: A retrospective cohort study approved by the Colorado Multiple Institutional Review Board. Patients aged 60-79 years, without diabetes or chronic kidney disease (CKD), newly treated for hypertension at a University of Colorado primary care clinics were included...
February 2017: Therapeutic Advances in Cardiovascular Disease
https://www.readbyqxmd.com/read/28019714/a-prospective-study-of-the-association-between-total-sleep-duration-and-incident-hypertension
#6
Dhananjay Yadav, Dae Sung Hyun, Song Vogue Ahn, Sang-Baek Koh, Jang Young Kim
The aim of this prospective study was to evaluate total sleep duration as a potential risk factor for the development of hypertension after a mean of 2.6 years of follow-up. The study participants comprised 1715 Korean adults aged 40 to 70 years. The participants were without hypertension at baseline (2005-2008) and during follow-up (2008-2011) to determine the incident cases of hypertension. Based on a self-reported questionnaire, the individuals were stratified according to total sleep duration (<6 hours, 6-7...
December 26, 2016: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/27976382/early-glycolipid-poa-in-pro-oligodendroblasts-revealed-to-be-sulfatide-an-editorial-highlight-for-sulfatide-species-with-various-fatty-acid-chains-in-oligodendrocytes-at-different-developmental-stages-determined-by-imaging-mass-spectrometry
#7
EDITORIAL
Joan M Boggs
This Editorial highlights a study by Hirahara et al. J. Neurochem. (2016) in the current issue of the Journal of Neurochemistry, in which the authors used mass spectrometry to detect sulfatide with short chain fatty acids, C16, C18, and C18:0H in pro-oligodendroblasts at embryonic stages. These findings show that sulfatide is the pro-oligodendroblast antigen(POA) glycolipid that reacts with O4 monoclonal antibody. The different sulfatide species may perform different roles during cell development and in myelin...
December 15, 2016: Journal of Neurochemistry
https://www.readbyqxmd.com/read/27976378/the-human-brain-endothelial-barrier-transcytosis-of-aav9-transduction-by-aav2-an-editorial-highlight-for-trafficking-of-adeno-associated-virus-vectors-across-a-model-of-the-blood-brain-barrier-a-comparative-study-of-transcytosis-and-transduction-using-primary
#8
EDITORIAL
Danielle Weber-Adrian, Stefan Heinen, Joseph Silburt, Zeinab Noroozian, Isabelle Aubert
Endothelial cells at the blood-brain barrier prevent the passage of adeno-associated virus 2 (AAV2) but not AAV9. This editorial highlights a study by Merkel et al. (2016) in which a barrier, composed of human brain microvascular endothelial cells in culture, was used to characterize the trafficking mechanisms leading primarily to transduction of endothelial cells for AAV2, and transcytosis for AAV9. Read the highlighted article 'Trafficking of adeno-associated virus vectors across a model of the blood-brain barrier; a comparative study of transcytosis and transduction using primary human brain endothelial cells' on doi: 10...
December 15, 2016: Journal of Neurochemistry
https://www.readbyqxmd.com/read/27957711/the-role-of-beta-blockers-in-the-treatment-of-hypertension
#9
John M Cruickshank
IMPORTANCE: Two major guide-line committees (JNC-8 and NICE UK) have dropped beta-blockers as first-line therapy in the treatment of hypertension. Also, recent meta-analyses (that do not take age into account) have concluded that beta-blockers are inappropriate first-line agents in the treatment of hypertension. This review seeks to shed some light on the "rights and wrongs" of such actions and conclusions. OBJECTIVES: Because the pathophysiology of primary/essential hypertension differs in elderly and younger subjects, the latter being closely linked to obesity and increased sympathetic nerve activity, the author sought to clarify the efficacy of beta-blockers in the younger/middle-aged group in reducing the risk of death, and cardiovascular end-points...
December 13, 2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27899129/a-community-based-study-on-prevalence-and-correlates-of-erectile-dysfunction-among-kinondoni-district-residents-dar-es-salaam-tanzania
#10
Pedro Pallangyo, Paulina Nicholaus, Peter Kisenge, Henry Mayala, Noel Swai, Mohamed Janabi
BACKGROUND: Globally, erectile dysfunction burden (ED) is rising appreciably and it is projected to affect about 332 million men by the year 2025. This rise is attributable to the rising incidence of conditions associated with ED including obesity, diabetes, hypertension, coronary artery disease and depression. We conducted this community-based screening to elucidate on the prevalence of ED and its associated factors among men residing in an urban community in Tanzania. METHODS: We conducted a cross-sectional community-based study and interviewed 441 men aged at least 18 years...
November 29, 2016: Reproductive Health
https://www.readbyqxmd.com/read/27891330/evaluation-of-lipid-profile-and-apolipoproteins-in-essential-hypertensive-patients
#11
Parsuram Nayak, Suchismita Panda, Pravat Kumar Thatoi, Roma Rattan, Srikrushna Mohapatra, Pramila Kumari Mishra
INTRODUCTION: Essential hypertension is one of the most common diseases of the Indian population contributing greatly to the morbidity, mortality and economic burden. It has a strong association with cardiovascular disease and abnormal lipid metabolism. Not only the traditional lipid parameters, but also the novel lipid components like Apo A1 and Apo B100 also have been identified to play a role. AIM: The present study was done to evaluate serum lipid profile and Apo A1, Apo B 100 in essential hypertensive patients and correlate their values with the degree of hypertension...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27858343/industry-corner-invitation-from-jnc-to-industry-scientists
#12
(no author information available yet)
No abstract text is available yet for this article.
November 17, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/27856202/total-antihypertensive-therapeutic-intensity-score-and-its-relationship-to-blood-pressure-reduction
#13
Phillip D Levy, Robina Josiah Willock, Michael Burla, Aaron Brody, James Mahn, Alexander Marinica, Samar A Nasser, John M Flack
Predicting blood pressure (BP) response to antihypertensive therapy is challenging. The therapeutic intensity score (TIS) is a summary measure that accounts for the number of medications and the relative doses a patient received, but its relationship to BP change and its utility as a method to project dosing equivalence has not been reported. We conducted a prospective, single center, randomized controlled trial to compare the effects of Joint National Committee (JNC) 7 compliant treatment with more intensive (<120/80 mm Hg) BP goals on left ventricular structure and function in hypertensive patients with echocardiographically determined subclinical heart disease who were treated over a 12-month period...
December 2016: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/27844332/proceedings-from-the-2016-jnc-board-meeting
#14
EDITORIAL
Ami E Iskandrian
No abstract text is available yet for this article.
November 14, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/27754307/lbos-03-02-prehypertension-and-hypertension-in-urban-suriname-the-helisur-study
#15
Fares Karamat, Frederieke Diemer, Sergio Baldew, Glen Oehlers, Gert Van Montfrans, Lizzy Brewster
OBJECTIVE: The global burden of disease attributable to high blood pressure showed that 54% of stroke and 47% of ishaemic heart disease worldwide were due to hypertension. Hypertension is still the main risk factor for premature death worldwide and, in particular, in low- and middle-income countries. We aimed to assess prehypertension and hypertension prevalence among a predominantly Asian and African population living in urban Suriname, a middle-income country in South America. DESIGN AND METHOD: We used data from the Healthy Life in Suriname study, in which 1,152 men and women aged 18-70 y living in the capital were randomly selected...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27754180/ed-08-4-diagnosis-and-treatment-of-hypertensive-emergency-in-children
#16
Lin Shi
According to the seventh report of Joint National Committee (JNC 7), hypertensive emergency (HE), a kind of hypertensive crisis, is defined as a sudden and abrupt elevation in blood pressure so as to cause acute target organ dysfunctions, including central nervous system, cardiovascular system or kidneys. Patients with HE require immediate reduction in markedly elevated blood pressure. Currently, there are no international guidelines for children HE, so the JNC definition is commonly used. Hypertensive emergency in children is rare but a life-threatening emergency...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27754110/os-22-06-evaluating-the-health-related-quality-of-life-of-hypertensive-patients
#17
Mansi Patil, Manoj Durairaj, Syed Mohammed Tauseef
OBJECTIVE: To evaluate and assess the health related quality of life (HRQOL) of hypertensive patients in West India using the MINCHAL scale and WHO-BREF questionnaire. DESIGN AND METHOD: 500 male hypertensives (age group 20-60 years) that were on anti-hypertensive treatment for minimum six months were chosen for a cross-sectional study. They were divided into 3 categories of hypertension according to the JNC-7 classification i.e., Stage 1 and Stage 2 as "uncontrolled" hypertension and pre-hypertensive as "controlled" hypertension...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27754095/os-20-09-diagnosis-and-treatment-of-cognitive-disorders-in-arterial-hypertension
#18
Viktoria Krotova, Tatyana Khomazyuk
OBJECTIVE: One of the first disorders of affection subcortical brain structures in arterial hypertension (AH) is a decrease in mental processes, intellectual rigidity. To investigate the cognitive disorders (CD) in AH patients 1-2 stages of working age and the effectiveness of nootropic agent (phenibutum) and anticholinergic drug (ipidacrinum) in combined antihypertensive therapy. DESIGN AND METHOD: Observed 60 patients with controlled AH 1-2 stages and CD. The median age-55,3 ± 9,1 years and duration of AH-10,2 ± 5,8 years...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27754018/js-ksh-jsh-chl-01-1-cardio-metabolic-risks-in-hypertension-are-we-different-from-western-societies
#19
Hiroshi Itoh
Many hypertension guidelines have been published mainly from Western countries to standardize the management of hypertension all over the world, however, the significance of hypertension, along with other cardio-metabolic risks, such as obesity, diabetes or dyslipidemia should differ among different races. This paper compares the relevance of hypertension, one of the most important cardio-metabolic risk factors, in Asian and Western societies.1) Low target level of blood pressure control for diabetic hypertensives in JapanIn the Japanese Society of Hypertension Guidelines for the management of Hypertension (JSH2014), the target of blood pressure (BP) control in hypertensive patients with diabetes was set as < 130/80 mmHg...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27754001/db-02-3-strict-control-of-hypertension-in-the-elderly-with-diabetes-and-chronic-kidney-disease-pro
#20
Lawrence Appel
The identification of explicit blood pressure targets for clinical management remains controversial, particularly in older individuals with co-morbidities. Recommendations from the panel appointed to the Eighth Joint National Committee (JNC 8) and results of the SPRINT trial have rekindled interest in this issue. JNC8 recommended a higher (more relaxed) BP goal of < 150/90, instead of the traditional BP goal of <140/90, in persons aged 60+. In contrast, the recently completed SPRINT trial, which enrolled high risk patients without diabetes, documented that a lower (more stringent) SBP goal of <120 mmHg reduced total mortality and cardiovascular disease events compared to <140 mmHg...
September 2016: Journal of Hypertension
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