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https://www.readbyqxmd.com/read/29146532/potential-u-s-population-impact-of-the-2017-american-college-of-cardiology-american-heart-association-high-blood-pressure-guideline
#1
Paul Muntner, Robert M Carey, Samuel Gidding, Daniel W Jones, Sandra J Taler, Jackson T Wright, Paul K Whelton
BACKGROUND: The 2017 American College of Cardiology/American Heart Association (ACC/AHA) Guideline for the Prevention, Detection, Evaluation and Management of High Blood Pressure in Adults provides recommendations for the definition of hypertension, systolic and diastolic blood pressure (BP) thresholds for initiation of antihypertensive medication and BP target goals. OBJECTIVE: Determine the prevalence of hypertension, implications of recommendations for antihypertensive medication and prevalence of BP above the treatment goal among US adults using criteria from the 2017 ACC/AHA and the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation and Treatment of High Blood Pressure (JNC7) guidelines...
November 6, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29133599/potential-u-s-population-impact-of-the-2017-american-college-of-cardiology-american-heart-association-high-blood-pressure-guideline
#2
Paul Muntner, Robert M Carey, Samuel Gidding, Daniel W Jones, Sandra J Taler, Jackson T Wright, Paul K Whelton
Background -The 2017 American College of Cardiology/American Heart Association (ACC/AHA) Guideline for the Prevention, Detection, Evaluation and Management of High Blood Pressure in Adults provides recommendations for the definition of hypertension, systolic and diastolic blood pressure (BP) thresholds for initiation of antihypertensive medication and BP target goals. The objective of this study was to determine the prevalence of hypertension, implications of recommendations for antihypertensive medication and prevalence of BP above the treatment goal among US adults using criteria from the 2017 ACC/AHA and the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation and Treatment of High Blood Pressure (JNC7) guidelines...
November 13, 2017: Circulation
https://www.readbyqxmd.com/read/29063904/study-of-carotid-intimal-medial-thickness-in-essential-hypertension-with-or-without-left-ventricular-hypertrophy
#3
Himanshu Khutan, Simmi Aggarwal, K S Kajal, Ravinder Garg, Rupinderjeet Kaur, Amanpreet Kaur
INTRODUCTION: Hypertension and atherosclerosis though separate entities, are interrelated as hypertension plays an important role in the pathogenesis of atherosclerosis. This study was undertaken to study the association of carotid intimal medial thickness with left ventricular hypertrophy (LVH) in hypertensive patients. MATERIALS AND METHODS: Hundred hypertensives (JNC-7, Stage 1 and 2) between 30 and 55 years were enrolled in this prospective observational study conducted at a tertiary care teaching institute of Punjab, India...
October 2017: Annals of African Medicine
https://www.readbyqxmd.com/read/28944460/ether-lipids-and-their-elusive-function-in-the-nervous-system-a-role-for-plasmalogens-an-editorial-highlight-for-reduced-muscle-strength-in-ether-lipid-deficient-mice-is-accompanied-by-altered-development-and-function-of-the-neuromuscular-junction-on-doi-10
#4
EDITORIAL
Eric J Murphy
In this editorial, we highlight the recent work of Dorninger et al. that demonstrates a reduction in plasmalogens in the motor end plate is associated with a reduction in motor end plate function. This reduction in function is illuminated in reduced muscle function in these mice, corresponding with the reduction in acetylcholine release and in its receptor density observed in these mice.
September 25, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28910594/concordance-between-common-hypertension-control-algorithms-in-electronic-medical-record-data
#5
Victoria M Nielsen, Amy Bettano, Mark Josephson, Laura Nasuti, W W Sanouri Ursprung
Because quality improvement metrics and treatment guidelines are used to conduct research, evaluate care quality, and assess population health, they should, ideally, align. We used electronic medical record data to analyze variation between blood pressure control estimates calculated by using thresholds derived from National Quality Forum 0018 (NQF 0018) and Joint National Committee (JNC) treatment guidelines in a cohort of patients with hypertension. Percentage of patients with controlled blood pressure derived from each quality improvement or treatment guideline cutoff varied up to 16...
September 14, 2017: Preventing Chronic Disease
https://www.readbyqxmd.com/read/28900587/prevalence-and-predictors-of-depression-amongst-hypertensive-individuals-in-karachi-pakistan
#6
Samar Mahmood, Syeda Z Hassan, Muqadus Tabraze, Mohammad O Khan, Iqra Javed, Ameer Ahmed, Omer M Siddiqui, Mehek Narmeen, Maham J Ahmed, Afreen Tariq, Mustafa S Patel, Kaneez Fatima
OBJECTIVE: While studies evaluating the prevalence of depression and hypertension have been extensively carried out in high income countries, there is a paucity of information assessing the prevalence of depression within hypertensive patients in low income nations. The primary objective of this study was to investigate the prevalence of undiagnosed depression in hypertensive patients within a tertiary care facility in Karachi, Pakistan. The secondary objective was to assess factors associated with undiagnosed depression in this group...
June 26, 2017: Curēus
https://www.readbyqxmd.com/read/28899928/treatment-of-hypertension-by-increasing-impaired-endothelial-trpv4-kca2-3-interaction
#7
Dongxu He, Qiongxi Pan, Zhen Chen, Chunyuan Sun, Peng Zhang, Aiqin Mao, Yaodan Zhu, Hongjuan Li, Chunxiao Lu, Mingxu Xie, Yin Zhou, Daoming Shen, Chunlei Tang, Zhenyu Yang, Jian Jin, Xiaoqiang Yao, Bernd Nilius, Xin Ma
The currently available antihypertensive agents have undesirable adverse effects due to systemically altering target activity including receptors, channels, and enzymes. These effects, such as loss of potassium ions induced by diuretics, bronchospasm by beta-blockers, constipation by Ca(2+) channel blockers, and dry cough by ACEI, lead to non-compliance with therapies (Moser, 1990). Here, based on new hypertension mechanisms, we explored a new antihypertensive approach. We report that transient receptor potential vanilloid 4 (TRPV4) interacts with Ca(2+)-activated potassium channel 3 (KCa2...
November 2017: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/28872674/the-methylazoxymethanol-acetate-rat-model-molecular-and-epigenetic-effect-in-the-developing-prefrontal-cortex-an-editorial-highlight-for-epigenetic-mechanisms-underlying-nmda-receptor-hypofunction-in-the-prefrontal-cortex-of-juvenile-animals-in-the-mam-model
#8
EDITORIAL
Xiyu Zhu, Felipe V Gomes, Anthony A Grace
This Editorial highlights an article by Gulchina and colleagues in the current issue of the Journal of Neurochemistry, in which the authors describe molecular and epigenetic changes in the developing prefrontal cortex of the rats exposed to methylazoxymethanol acetate (MAM). They found an NMDAR hypofunction present in the prefrontal cortex of juvenile MAM rats which was associated with abnormal epigenetic regulation of the Grin2b gene. These changes may be related to early cognitive impairments observed in MAM rats and schizophrenia patients...
November 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28868944/prehypertension-in-early-versus-late-pregnancy
#9
Jonathan Y Rosner, Megan Gutierrez, Margaret Dziadosz, Terri-Ann Bennett, Cara Dolin, Amelie Pham, Allyson Herbst, Sarah Lee, Ashley S Roman
INTRODUCTION: Hypertensive disorders play a significant role in maternal morbidity and mortality. Limited data on prehypertension (preHTN) in pregnancy exist. We examine the risk of adverse outcomes in patients with preHTN in early (<20 weeks) versus late pregnancy (>20 weeks). MATERIALS AND METHODS: Retrospective cohort study of singleton gestations between August 2013 and June 2014. Patients were divided based on when they had the highest blood pressure in pregnancy, as defined per the Joint National Committee 7 (JNC-7)...
September 12, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28862406/double-blind-randomized-controlled-clinical-trial-of-nacl-chitosan-3-vs-nacl-on-high-blood-pressure-parameters-of-healthy-volunteers-with-pre-hypertension-characterized-by-a-systolic-blood-pressure-between-130-mmhg-and-140-mmhg
#10
François-André Allaert
BACKGROUND: Because of the impressive increase in the risk of cardiovascular complications associated with levels of BP previously considered to be normal, the JNC 7 report has introduced a new classification that includes the term "prehypertension" for those with BPs ranging from 120-139 mmHg systolic and/or 80-89 mmHg diastolic. In the framework of a salt reduction as recommended by health authorities, this trial evaluates if the use of Symbiosal® reduces more prehypertension than standard table marine salt (NaCl)...
August 31, 2017: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/28833144/retraction-statement-anti-inflammatory-properties-of-tianeptine-on-lipopolysaccharide-induced-changes-in-microglial-cells-involve-toll-like-receptor-related-pathways
#11
(no author information available yet)
'Anti-inflammatory properties of tianeptine on lipopolysaccharide-induced changes in microglial cells involve toll-like receptor-related pathways' by Slusarczyk, J., Trojan, E., Glombik, K., Piotrowska, A., Budziszewska, B., Kubera, M., Popiolek-Barczyk, K., Lason, W., Mika, J. and Basta-Kaim, A. The above article from the Journal of Neurochemistry published on 14 February 2016 on Wiley Online Library ( www.onlinelibrary.com), and in Volume 136, pp. 958-970, is being retracted by agreement between the corresponding author Agnieszka Basta-Kaim, the Journal's Editor-in-Chief Jörg Schulz, and John Wiley & Sons Ltd...
September 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28828478/association-of-jnc-8-and-sprint-systolic-blood-pressure-levels-with-cognitive-function-and-related-racial-disparity
#12
Ihab Hajjar, Kristine J Rosenberger, Ambar Kulshreshtha, Hilsa N Ayonayon, Kristine Yaffe, Felicia C Goldstein
Importance: The Eighth Joint National Committee (JNC-8) recommended treating systolic blood pressure (SBP) to a target below 150 mm Hg in older adults, whereas data from the Systolic Blood Pressure Intervention Trial (SPRINT) suggested that a SBP level of lower than 120 mm Hg decreases cardiovascular event rates. Target SBP guidelines have not addressed the potential that black patients may have greater morbidity and mortality from hypertension, especially with regard to cognitive outcomes...
October 1, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28822507/prevalence-and-incidence-of-hypertension-results-from-a-representative-cohort-of-over-16-000-adults-in-three-cities-of-south-asia
#13
Dorairaj Prabhakaran, Panniyammakal Jeemon, Shreeparna Ghosh, Roopa Shivashankar, Vamadevan S Ajay, Dimple Kondal, Ruby Gupta, Mohammed K Ali, Deepa Mohan, Viswanathan Mohan, Masood M Kadir, Nikhil Tandon, Kolli Srinath Reddy, K M Venkat Narayan
BACKGROUND: Despite high projected burden, hypertension incidence data are lacking in South Asian population. We measured hypertension prevalence and incidence in the Center for cArdio-metabolic Risk Reduction in South Asia (CARRS) adult cohort. METHODS: The CARRS Study recruited representative samples of Chennai, Delhi, and Karachi in 2010/11, and socio-demographic and risk factor data were obtained using a standard common protocol. Blood pressure (BP) was measured in the sitting position using electronic sphygmomanometer both at baseline and two year follow-up...
July 2017: Indian Heart Journal
https://www.readbyqxmd.com/read/28809040/a-mobile-app-for-sharing-contacts-on-your-cell-an-editorial-highlight-for-the-physiological-role-of-the-amyloid-precursor-protein-as-an-adhesion-molecule-in-the-developing-nervous-system-on-page-11
#14
EDITORIAL
George William Rebeck, Daniel T S Pak
The Review highlighted in this Editorial followed a CAEN Return Home Grant.
October 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28776681/another-piece-in-the-progranulin-puzzle-special-binding-between-progranulin-and-prosaposin-creates-additional-lysosomal-access-an-editorial-comment-for-the-interaction-between-progranulin-and-prosaposin-is-mediated-by-granulins-and-the-linker-region-between
#15
EDITORIAL
Philip Van Damme
Loss-of-function mutations in the gene encoding the growth factor progranulin cause degeneration of the ageing brain in a dose-dependent manner. While heterozygous mutations result in adult onset frontotemporal dementia, the much rarer homozygous null mutations cause an early onset lysosomal storage disorder. A better understanding of the biology of progranulin in the central nervous system is needed to find solutions for these incurable diseases. This Editorial highlights a study by Zhou et al. in the current issue of the Journal of Neurochemistry, in which the authors provide data that are a step towards this goal...
October 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28770441/association-of-dd-genotype-of-angiotensin-converting-enzyme-gene-i-d-polymorphism-with-hypertension-among-a-north-indian-population
#16
Garima Rana, Suniti Yadav, Shipra Joshi, K N Saraswathy
Hypertension, a major risk factor for cardiovascular diseases, is among the leading causes of morbidity and mortality worldwide. Genetic predisposition to the risk of developing hypertension due to angiotensin-converting enzyme (ACE) gene insertion(I)/deletion(D) polymorphism (through altered serum ACE activity) is well documented among various populations. The present study investigated the possible association between ACE (DD) genotype and hypertension using a nested case-control study design including 451 individuals (of either sex in the age group 30-65 years) from a rural North Indian population practicing agriculture and lacto-vegetarianism...
August 2, 2017: Journal of Community Genetics
https://www.readbyqxmd.com/read/28741701/dissecting-molecular-architecture-of-post-synaptic-density-at-excitatory-synapses-an-editorial-highlight-for-hierarchical-organization-and-genetically-separable-subfamilies-of-psd95-postsynaptic-supercomplexes-on-page-504
#17
EDITORIAL
Jinjun Chen, Hui-Lin Pan
This Editorial highlights a study by Frank and colleagues (2017) in the current issue of Journal of Neurochemistry. The authors report the genetic composition and stoichiometry of endogenous subfamilies of PSD95-containing supercomplexes in the mouse brain using an innovative strategy of combining gene-tagging knock-in, targeted mutations, and quantitative biochemical assays. Their findings shed new light on our understanding of the genetic hierarchy required for the assembly of distinct supercomplex subfamilies at excitatory synapses in the brain...
August 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28736837/acute-effects-of-alcohol-on-sleep-are-mediated-by-components-of-homeostatic-sleep-regulatory-system-an-editorial-highlight-for-lesions-of-the-basal-forebrain-cholinergic-neurons-attenuates-sleepiness-and-adenosine-after-alcohol-consumption-on-page-710
#18
EDITORIAL
Md Noor Alam, Dennis McGinty
Alcohol causes adenosine buildup, which inhibits wake-active neurons via adenosine A1 receptors thus disinhibiting sleep active neurons and also stimulates sleep-active neurons via A2A receptors, causing sleep. This editorial highlights the study entitled, "Lesions of the basal forebrain cholinergic neurons attenuates sleepiness and adenosine after alcohol consumption" by Sharma and colleagues. They report that the wake-promoting basal forebrain (BF) cholinergic neurons play a crucial role in mediating acute alcohol-induced sleep via adenosinergic signaling...
September 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28707234/the-elusive-search-for-optimal-blood-pressure-targets
#19
REVIEW
Alan H Gradman
BP treatment thresholds/targets determine when to initiate treatment and to what level BP should be reduced. The Seventh Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC-7) recommended a target of <140/90 for most patients and a target <130/80 mmHg for patients with diabetes or chronic kidney disease. Subsequently, meta-analyses, retrospective studies relating on-treatment BP to clinical outcomes and two large, randomized clinical trials (RCTs) have re-evaluated BP targets...
August 2017: Current Hypertension Reports
https://www.readbyqxmd.com/read/28658794/a-comparative-study-on-clinical-and-biochemical-parameters-in-amlodipine-and-cilnidipine-treated-hypertensive-patients
#20
Kiran Shetty, Ranjan Shetty, Lakshminarayana Bairy, Pragna Rao, Amruth Kiran, Manjunath Shetty, Deepak, Vidya Nayak
INTRODUCTION: Hypertension is a major health issue worldwide. Calcium Channel Blockers (CCBs) are the most commonly used antihypertensive agents. CCBs act on voltage-dependent calcium channels and they were categorized into two subclasses, Dihydropyridine (DHP) and non-Dihydropyridine (non-DHP) derivative. Amlodipine is a third generation L-type of DHP and Cilnidipine is a novel L/N-type of DHP CCB, both drugs have excellent pharmacological profiles with the unique actions. AIM: To study the clinical and biochemical profile in Amlodipine and Cilnidipine treated mild to moderate hypertensive patients...
May 2017: Journal of Clinical and Diagnostic Research: JCDR
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