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https://www.readbyqxmd.com/read/29716872/measuring-central-percentiles-of-blood-pressure-levels-among-adults-in-pakistan-a-case-study-of-rawalpindi
#1
Sumaira Mubarik, Muhammad Aslam
The prevalence pattern of hypertension (HTN) in developing countries is different from that in the developed countries. In Pakistan, the percentage of hypertensive patients has been growing since last two decades. Various factors might have contributed to this rising trend like, age, body mass index (BMI), lack of physical activity, family history of HTN and smoking etc. In this study, we examine prevalence of HTN in Rawalpindi district of Pakistan using the Eighth Joint National Committee (JNC 8) criteria, with the aim to measure central percentiles of blood pressure (BP) depending on different stated factors...
May 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29680839/decreased-migration-of-dendritic-cells-into-the-jugular-nodose-ganglia-by-the-cxcl12-neutraligand-chalcone-4-in-ovalbumin-sensitized-asthmatic-mice
#2
Sebastian Heck, François Daubeuf, Duc Dung Le, Martina Sester, Dominique Bonnet, Robert Bals, Nelly Frossard, Quoc Thai Dinh
OBJECTIVE: The chemokine CXCL12 interacting with the CXC receptor 4 (CXCR4) has been reported to play a role in the development and progression of bronchial asthma, but its mechanism of action is still unknown. The objective of this study was to assess the effect of the CXCL12 neutraligand chalcone 4 on the migration of dendritic cells (DCs) in a murine model of allergic airway inflammation. METHODS: A 21-day ovalbumin (OVA)-induced allergic-airway TH2 inflammation model in BALB/c mice was used...
April 20, 2018: Neuroimmunomodulation
https://www.readbyqxmd.com/read/29674798/switching-of-antihypertensive-drugs-at-tertiary-care-government-hospital-hyderabad-india-a-cross-sectional-retrospective-investigation
#3
Varsha Varakantham, Ashok Kumar Kurakula Sailoo, Venkaiah Kodali, Dinesh Kumar Bharatraj
OBJECTIVE: Switching of antihypertensive drugs is attributed to uncontrolled blood pressure (BP) which imposes a great burden on health economics. But again, switching leads to accomplishment of the goal BP, thereby improving the health status. Such studies are well documented in developed nations but rarely reported in developing countries, especially in India. Therefore, the aim of this study was to evaluate various factors associated with switching of antihypertensive drugs. METHODS: A cross-sectional retrospective investigation was performed using a standardized schedule adapting the World Health Organization indicators for drug utilization in a tertiary care government hospital, Hyderabad, India...
November 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/29663393/maternal-obesity-reprograms-offspring-s-executive-brain-centers-in-a-sex-specific-manner-an-editorial-for-perinatal-high-fat-diet-and-early-life-methyl-donor-supplementation-alter-one-carbon-metabolism-and-dna-methylation-in-the-brain-on-doi-10-1111-jnc-14319
#4
EDITORIAL
Kaja Plucińska, Steven W Barger
This editorial highlights an article by McKee and colleagues in the current issue of Journal of Neurochemistry, in which the authors report epigenetic changes linked to one-carbon metabolism in prefrontal cortex (PFC) of murine offspring from dams fed high-fat diet to mimic maternal obesity. The group found that high-fat diet feeding in utero increases weight gain in offspring and dynamically alters DNA methylation in the PFC of male but not female brains. These epigenetic marks were associated with a shift in brain one-carbon metabolism (folate and methionine) intermediates and were normalized by early-life methyl-donor supplementation in a sex-specific manner...
April 16, 2018: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29581605/antihypertensive-prescription-pattern-and-compliance-to-jnc-7-and-jnc-8-at-tertiary-care-government-hospital-hyderabad-india-a-cross-sectional-retrospective-study
#5
Varsha Varakantham, Ashok Kumar Kurakula Sailoo, Dinesh Kumar Bharatraj
Background: The monitoring of hypertension treatment can provide insight into the rational drug use pattern. The objective of this study was to examine the antihypertensive medication use among South Indian adults with hypertension in compliance with the hypertension treatment guidelines (Seventh Joint National Committee [JNC 7] and JNC 8). Methods and Results: A total of 550 hypertensive people aged >25 years were included in this retrospective cross-sectional study. The order of drugs prescribed in the year 2012 was beta blockers (BB) > calcium channel blockers (CCB) > CCB + BB > angiotensin receptor blockers (ARB) > angiotensin-converting enzyme inhibitors (ACEI) > thiazide diuretics, whereas in the year 2014, the order has changed drastically, namely, ACEI > CCB > ARB > BB > thiazide diuretics ( P < ...
April 2018: Hospital Pharmacy
https://www.readbyqxmd.com/read/29569088/visceral-adiposity-index-vai-a-powerful-predictor-of-incident-hypertension-in-prehypertensives
#6
Zhipeng Zhang, Di Shi, Qiang Zhang, Si Wang, Kai Liu, Qingtao Meng, Xiaoping Chen
Prehypertension (defined by The Seventh Report of the Joint National Committee on the Prevention, Detection, Evaluation, and Treatment of High Blood Pressure, JNC-7) is relevant to a higher cardiovascular risk than normotensives. Early intervention in this particular population is essential to avoid progression into hypertension (HTN). This study is to explore whether visceral adiposity index (VAI) can strongly predict the incidence of HTN in community-based prehypertensives. A prospective observational cohort study was conducted from September 2011 to June 2012 in urban communities of Chengdu, Sichuan Province, China...
March 22, 2018: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/29511926/editor-in-chief-round-up-jnc-s-top-performers-of-2017-jnc-asnc-podcast-manuscript-transfer-service-and-our-new-section-basic-and-translational-preclinical-studies
#7
Ami E Iskandrian
No abstract text is available yet for this article.
April 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29504458/beyond-jnc-8-implications-for-evaluation-and-management-of-hypertension-in-underserved-populations
#8
Joseph Burns, Dharam Persaud-Sharma, Dollie Green
In the United States, hypertension is a significant medical problem that affects nearly 1 in 3 adults, causes thousands of deaths annually, and costs the nation billions of dollars annually for medical management in terms of hospitalisations, lost wages, and pharmacotherapy. The management guidelines of hypertension have greatly varied between different healthcare organisations including the American College of Cardiology (ACC), the European Society of Cardiology (ESC) and the Joint National Committee (JNC-7, 8)...
March 5, 2018: Acta Cardiologica
https://www.readbyqxmd.com/read/29473120/analogies-and-disparities-among-scintigraphic-bone-tracers-in-the-diagnosis-of-cardiac-and-non-cardiac-attr-amyloidosis
#9
EDITORIAL
Claudio Rapezzi, Christian Gagliardi, Agnese Milandri
In this issue of JNC, BW Spery and Coll report a retrospective analysis of 57 patients with transthyretin-related amyloidosis (ATTR) in an advanced phase of the disease who underwent 99mTechnetium-pyrophosphate (99mTcPYP) scintigraphy. Although relatively small and "negative," the study is relevant since it broadens our knowledge on the uptake of "bone tracers" in ATTR and contributes to understand the limitations of the clinical use of scintigraphy in this disease. The paper raises, directly or indirectly, at least three questions: To what extent are the different bone tracers interchangeable for the diagnosis of ATTR cardiac amyloidosis? Are bone tracers able to image non-cardiac ATTR amyloidosis? What is the explanation for the variable performance of the different bone tracers in the diagnosis of cardiac and extracardiac ATTR amyloidosis?...
February 22, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29438278/towards-efficient-wireless-body-area-network-using-two-way-relay-cooperation
#10
Maham Waheed, Rizwan Ahmad, Waqas Ahmed, Micheal Drieberg, Muhammad Mahtab Alam
The fabrication of lightweight, ultra-thin, low power and intelligent body-borne sensors leads to novel advances in wireless body area networks (WBANs). Depending on the placement of the nodes, it is characterized as in/on body WBAN; thus, the channel is largely affected by body posture, clothing, muscle movement, body temperature and climatic conditions. The energy resources are limited and it is not feasible to replace the sensor's battery frequently. In order to keep the sensor in working condition, the channel resources should be reserved...
February 13, 2018: Sensors
https://www.readbyqxmd.com/read/29421687/baseline-blood-pressure-the-2017-acc-aha-high-blood-pressure-guidelines-and-long-term-cardiovascular-risk-in-sprint
#11
Muthiah Vaduganathan, Manan Pareek, Arman Qamar, Ambarish Pandey, Michael H Olsen, Deepak L Bhatt
BACKGROUND: The 2017 American College of Cardiology (ACC)/American Heart Association (AHA) guidelines include lower thresholds to define hypertension than previous guidelines. Little is known about the impact of these guideline changes in patients with or at high risk for cardiovascular disease. METHODS: In this exploratory analysis using baseline blood pressure assessments in Systolic Blood Pressure Intervention Trial (SPRINT), we evaluated the prevalence and associated cardiovascular prognosis of patients newly reclassified with hypertension based on the 2017 ACC/AHA (systolic blood pressure ≥130 mm Hg or diastolic blood pressure ≥80 mm Hg) compared with the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation and Treatment of High Blood Pressure (JNC 7) guidelines (systolic blood pressure ≥140 mm Hg or diastolic blood pressure ≥90 mm Hg)...
February 5, 2018: American Journal of Medicine
https://www.readbyqxmd.com/read/29416120/relationship-of-serum-immunoglobulin-levels-to-blood-pressure-and-hypertension-in-an-adult-population
#12
Xiaotong Wang, Yajun Li, Huihui Li, Yeqing Gu, Yanqi Song, Qing Zhang, Li Liu, Ge Meng, Zhanxin Yao, Hongmei Wu, Yang Xia, Xue Bao, Hongbin Shi, Qian Su, Liyun Fang, Huijun Yang, Fei Yu, Shaomei Sun, Xing Wang, Ming Zhou, Huanli Jiao, Qiyu Jia, Kun Song, Yuntang Wu, Hong Chang, Kaijun Niu
Evidence suggests long-term chronic inflammation, as the pathological basis of formation and development, plays an important part in atherosclerosis. Immunoglobulins (Igs) provided key information on the humoral immune status. However, few studies have evaluated the correlation between Igs and hypertension and blood pressure (BP) in a general population. We designed a cross-sectional study to evaluate whether serum Ig levels are related to BP and the prevalence of hypertension. About 12,373 participants in Tianjin, China were recruited for this study...
March 2018: Journal of Human Hypertension
https://www.readbyqxmd.com/read/29375010/aggressive-systolic-blood-pressure-control-in-older-subjects-benefits-and-risks
#13
REVIEW
Steven G Chrysant
Systolic hypertension, especially isolated systolic hypertension (ISH) is very common in older subjects aged ≥ 65 years and is a major risk factor for cardiovascular disease (CVD), strokes, heart failure (HF) and chronic kidney disease (CKD). It is also, directly and linearly related with these complications irrespective of sex, or ethnicity, but it is worse with the advancement of age. Effective control of systolic blood pressure (SBP), is associated with significant reduction in the incidence of these complications...
March 2018: Postgraduate Medicine
https://www.readbyqxmd.com/read/29372570/wnt-is-here-could-wnt-signalling-be-promoted-to-protect-against-alzheimer-disease-an-editorial-for-wnt-signaling-loss-accelerates-the-appearance-of-neuropathological-hallmarks-of-alzheimer-s-disease-in-j20-app-transgenic-and-wild-type-mice-on-doi-10-1111-jnc
#14
EDITORIAL
Brett Garner, Lezanne Ooi
This Editorial highlights an article in the current issue by Tapia-Rojas and Inestrosa suggesting that attenuation of Wnt signalling may be a triggering factor for the pathogenesis of Alzheimer disease (AD) in the J20 mouse model of AD. Their study utilises Wnt signalling inhibitors that operate at different points in the signalling pathway. The molecular changes of several key Wnt signaling components are examined, along with a thorough analysis of both the amyloid and tau based pathologies in the mouse brain...
February 2018: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29331037/pharmacist-intervention-for-blood-pressure-control-in-patients-with-diabetes-and-or-chronic-kidney-disease
#15
Maxwell D Anderegg, Tyler H Gums, Liz Uribe, Eric J MacLaughlin, James Hoehns, Oralia V Bazaldua, Timothy J Ives, David L Hahn, Christopher S Coffey, Barry L Carter
OBJECTIVES: The objectives of this study were to determine if hypertensive patients with comorbid diabetes mellitus (DM) and/or chronic kidney disease (CKD) receiving a pharmacist intervention had a greater reduction in mean blood pressure (BP) and improved BP control at 9 months compared with those receiving usual care; and compare Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC 7) guideline and 2014 guideline (JNC 8) BP control rates in patients with DM and/or CKD...
March 2018: Pharmacotherapy
https://www.readbyqxmd.com/read/29315727/considerations-for-optimal-blood-pressure-goals-in-the-elderly-population-a-review-of-emergent-evidence
#16
REVIEW
Diana X Cao, Rebecca J C Tran
Recent hypertension clinical trials and national guideline updates have created a debate on the most appropriate treatment goals in elderly patients with hypertension. In 2014, recommendations by the Eighth Joint National Committee allowed a more lenient goal for patients 60 years and older compared with previous guidelines. Since then, several large clinical trials and meta-analyses have added more information regarding strict versus lenient treatment goals. Most recently, the American College of Cardiology and American Heart Association Task Force published their highly anticipated hypertension guideline developed in conjunction with nine additional interdisciplinary organizations...
March 2018: Pharmacotherapy
https://www.readbyqxmd.com/read/29306956/applying-a-big-data-literature-system-to-recommend-antihypertensive-drugs-for-hypertension-patients-with-diabetes-mellitus
#17
Jing-Xian Shu, Ying Li, Ting He, Ling Chen, Xue Li, Lin-Lin Zou, Lu Yin, Xiao-Hui Li, An-Li Wang, Xing Liu, Hong Yuan
BACKGROUND The explosive increase in medical literature has changed therapeutic strategies, but it is challenging for physicians to keep up-to-date on the medical literature. Scientific literature data mining on a large-scale of can be used to refresh physician knowledge and better improve the quality of disease treatment. MATERIAL AND METHODS This paper reports on a reformulated version of a data mining method called MedRank, which is a network-based algorithm that ranks therapy for a target disease based on the MEDLINE literature database...
January 7, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29285771/endotoxemia-rocks-sphingolipid-metabolism-at-the-blood-brain-barrier-an-editorial-highlight-for-alteration-of-sphingolipid-metabolism-as-a-putative-mechanism-underlying-lps-induced-bbb-disruption-on-page-172
#18
Eric Camerer
In this issue of the Journal of Neurochemistry, Vutukuri et al. evaluate the impact of endotoxemia-induced encephalopathy on the sphingosine-1-phosphate (S1P) signaling pathway at the blood-brain barrier (BBB). Four hours after intraperitoneal administration of lipopolysaccharides (LPS, 4 mg/kg) to mice, they first demonstrate BBB dysfunction and then evaluate changes in sphingolipid metabolites in serum, isolated brain microvessels (MBMV), and whole brain. In parallel, they investigate the fate of indicated S1P generating and metabolizing enzymes and S1P receptors in brain and MBMV...
January 2018: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29283072/onset-of-hypertension-in-leflunamide-treated-low-socioeconomic-rheumatoid-arthritis-patients-an-unseen-iceberg
#19
Muhammad Ishaq, Salma Razzaque, Fadieleh Shohail, Ajeet Kumar, Jibran Sualeh Muhammad
OBJECTIVE: To determine the frequency of new-onset hypertension in patients with Rheumatoid arthritis taking leflunomide, in comparison with methotrexate in Asian setting. MATERIAL AND METHODS: Perspective case-control study was conducted in 2014 in a tertiary care hospital located in Karachi Pakistan. Adult patients having rheumatoid arthritis were randomly prescribed leflunomide or methotrexate. Patients having chronic hypertension, proteinuria and chronic kidney disease were excluded...
December 27, 2017: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/29250778/news-isn-december-2017
#20
(no author information available yet)
The 2016 Mark Smith Award winner is Sunmin Jung (Seoul National University), for the pa per Dual-specificity phosphatase 26 (DUSP26) stimulates Aβ42 generation by promoting amyloid precursor protein axonal transport during hypoxia. Journal of Neurochemistry (2016) 137(5): 770-781, Sunmin Jung, Jihoon Nah, Jonghee Han, Seon-Guk Choi, Hyunjoo Kim, Jaesang Park, Ha-Kyung Pyo, Yong-Keun Jung. https://doi.org/10.1111/jnc.13597.
January 2018: Journal of Neurochemistry
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