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Colombe Saillard, Michael Darmon, Magali Bisbal, Antoine Sannini, Laurent Chow-Chine, Marion Faucher, Etienne Lengline, Norbert Vey, Didier Blaise, Elie Azoulay, Djamel Mokart
Outcome of patients undergoing allogenic hematopoietic stem cell transplantation (allo-HSCT) has improved. To investigate if this improvement can be transposed to the ICU setting, we conducted a systematic review and meta-analysis to assess short-term mortality of critically ill allo-HSCT patients admitted to the ICU and to identify prognostic factors of mortality. Public-domain electronic databases, including Medline via PubMed and the Cochrane Library were searched. All full-text articles written-English studies published from 2006 to 2016, including allo-HSCT adults transferred to the ICU were included...
April 27, 2018: Bone Marrow Transplantation
Colombe Saillard, Lara Zafrani, Michael Darmon, Magali Bisbal, Laurent Chow-Chine, Antoine Sannini, Jean-Paul Brun, Jacques Ewald, Olivier Turrini, Marion Faucher, Elie Azoulay, Djamel Mokart
Neutropenic enterocolitis (NE) is a diagnostic and therapeutic challenge associated with high mortality rates, with controversial opinions on its optimal management. Physicians are usually reluctant to select surgery as the first-choice treatment, concerns being raised regarding the potential risks associated with abdominal surgery during neutropenia. Nevertheless, no published studies comforted this idea, literature is scarce and surgery has never been compared to medical treatment. This review and meta-analysis aimed to determine the prognostic impact of abdominal surgery on outcome of neutropenic cancer patients presenting with NE, versus medical conservative treatment...
April 19, 2018: Annals of Intensive Care
S Yaacoubi, S Ayed, C Bornstain, F Vincent, For The Grrr-Oh Groupe de Recherche Respiratoire En Réanimation En Onco-Hématologie Http/Www Grrroh Com/
No abstract text is available yet for this article.
April 2018: Netherlands Journal of Medicine
François Vincent, Marcio Soares, Djamel Mokart, Virginie Lemiale, Fabrice Bruneel, Marouane Boubaya, Frédéric Gonzalez, Yves Cohen, Elie Azoulay, Michaël Darmon
OBJECTIVES: To assess outcomes at hospital discharge and day-120 after intensive care unit (ICU) discharge among patients with solid cancer admitted to ICU and to identify characteristics associated with in-hospital and day-120 after ICU discharge mortalities. DESIGN: International, multicenter, retrospective study. SETTING: Five ICUs in France and Brazil, two located in cancer centers, two in university affiliated and one in general hospitals...
March 27, 2018: Annals of Intensive Care
Adrien Mirouse, Matthieu Resche-Rigon, Virginie Lemiale, Djamel Mokart, Achille Kouatchet, Julien Mayaux, François Vincent, Martine Nyunga, Fabrice Bruneel, Antoine Rabbat, Christine Lebert, Pierre Perez, Anne Renault, Anne-Pascale Meert, Dominique Benoit, Rebecca Hamidfar, Mercé Jourdain, Michaël Darmon, Elie Azoulay, Frédéric Pène
BACKGROUND: Indications for red blood cell (RBC) transfusion in septic acute circulatory failure remain unclear. We addressed the practices and the prognostic impact of RBC transfusion in the early resuscitation of severe sepsis and septic shock in patients with hematological malignancies. METHODS: We performed a retrospective analysis of a prospectively collected database of patients with hematological malignancies who required intensive care unit (ICU) admission in 2010-2011...
December 2017: Annals of Intensive Care
Chiara Marzorati, Djamel Mokart, Frederic Pène, Virginie Lemiale, Achille Kouatchet, Julien Mayaux, François Vincent, Martine Nyunga, Fabrice Bruneel, Antoine Rabbat, Christine Lebert, Pierre Perez, Dominique Benoit, Giuseppe Citerio, Elie Azoulay, Stephane Legriel
BACKGROUND: Epidemiological studies of neurological complications in patients with hematological malignancies are scant. The objective of the study was to identify determinants of survival in patients with hematological malignancy and neurological failure. METHODS: Post hoc analysis of a prospective study of adults with hematological malignancies admitted for any reason to one of 17 university or university-affiliated participating ICUs in France and Belgium (2010-2012)...
2017: PloS One
Yoann Zerbib, Antoine Rabbat, Muriel Fartoukh, Naïke Bigé, Claire Andréjak, Julien Mayaux, Nicolas De Prost, Benoît Misset, Virginie Lemiale, Fabrice Bruneel, Julien Maizel, Sylvie Ricome, Frédéric Jacobs, Caroline Bornstain, Hervé Dupont, François Baudin, Elie Azoulay, Frédéric Pène
OBJECTIVES: Solid neoplasms can be directly responsible for organ failures at the time of diagnosis or relapse. The management of such specific complications relies on urgent chemotherapy and eventual instrumental or surgical procedures, combined with advanced life support. We conducted a multicenter study to address the prognosis of this condition. DESIGN: A multicenter retrospective (2001-2015) chart review. SETTING: Medical and respiratory ICUs...
July 2017: Critical Care Medicine
A Dupré, C Mousseaux, A Bouguerba, S Ayed, J Barchazs, M Boukari, D Goldgran-Toledano, C Bornstain, F Vincent
No abstract text is available yet for this article.
May 2017: La Revue de Médecine Interne
A Neuschwander, V Lemiale, M Darmon, F Pène, A Kouatchet, P Perez, F Vincent, J Mayaux, D Benoit, F Bruneel, A P Meert, M Nyunga, A Rabbat, D Mokart, E Azoulay
PURPOSE: The objectives of our study were to describe the outcome of patients with malignancies treated for acute respiratory distress syndrome (ARDS) with noninvasive ventilation (NIV) and to evaluate factors associated with NIV failure. METHODS: Post hoc analysis of a multicenter database within 20 years was performed. All patients with malignancies and Berlin ARDS definition were included. Noninvasive ventilation use was defined as NIV lasting more than 1 hour, whereas failure was defined as a subsequent requirement of invasive ventilation...
April 2017: Journal of Critical Care
Caroline Roesler, Isabelle Pautre, Dominique Thirry, Soccoro Flores, Catherine Chabbert, Nikita Savre, Michèle Pibarot, Marie-Aude Seveau, Karyn Dugas, Zoé Rollin, Sarah Dumont, Nathalie Gaspar
Socialisation, education, first jobs and autonomy are key steps to teenagers and young adults (TYA) integration into the society. The occurrence of a cancer in this population increases the difficulties. Although, suffering of cancer do affect TYA life journey at social, scholar and professional levels, from diagnosis to the after-cancer live and sometime forever, few studies exist in France. A national study on TYA with cancer (TYAC) social, scholar and professional pathways is on-going (ESPOIR-AJA). A national survey of the existing TYAC insertion support in 2013 by the "Insertion group" of groupe onco-hématologie adolescents et jeunes adultes (GO-AJA) revealed structured and ancient support at scholar level based on national governmental or associative structures, but insufficient and non-specific scholar help in secondary school and professional help...
December 2016: Bulletin du Cancer
O Naseer, J A Khan, M S Khan, M O Omer, G A Chishti, M L Sohail, M U Saleem
Aflatoxins are secondary metabolites produced by Aspergillus spp. which are injurious to animals and humans The aim of this study was to determine the effects of aflatoxin B1 (AFB1) on Average Daily Feed Intake (ADFI), Average Daily Weight Gain (ADWG), haematological and serum biochemical responses of Bovine Calves and to determine the comparative efficacy of two different liver tonics against AFB1. Twenty seven calves were selected from herd and divided into 3 groups. All calves were fed with 1.0 mg/kg AFB1 for a period of 10 days...
September 1, 2016: Polish Journal of Veterinary Sciences
Marie Bouteloup, Sophie Perinel, Aurélie Bourmaud, Elie Azoulay, Djamel Mokart, Michael Darmon
PURPOSE: Whether neutropenia has an impact on the mortality of critically ill cancer patients remains controversial, yet it is widely used as an admission criterion and prognostic factor. METHODS: Systematic review and meta-analysis. Studies on adult cancer patients and intensive care units were searched on PubMed and Cochrane databases (2005-2015). Summary estimates of mortality risk differences were calculated using the random-effects model. RESULTS: Among the 1,528 citations identified, 38 studies reporting on 6,054 patients (2,097 neutropenic patients) were included...
January 3, 2017: Oncotarget
A Dupré, C Mousseaux, A Bouguerba, S Ayed, J Barchazs, M Boukari, D Goldgran-Toledano, C Bornstain, F Vincent
Whether it appears spontaneously or is induced by therapy, the tumor lysis syndrome is responsible for a massive release of ions and puric bases degradation of products in the circulation exceeding the renal excretion capacity. Some, such as uric acid, xanthine, and calcium phosphate, can precipitate in the renal tubules or parenchyma. It must be known to any practitioner supporting patients with hematologic malignancies, mainly high-grade but also some solid tumors. The 2015 publication of the British recommendations pertaining to patients suffering from hematological diseases should be broadcast...
January 2017: La Revue de Médecine Interne
(no author information available yet)
No abstract text is available yet for this article.
June 2016: Annals of Intensive Care
Benoit Champigneulle, Alain Cariou, François Vincent
No abstract text is available yet for this article.
January 2016: JAMA Internal Medicine
Michael Darmon, François Vincent, Emmanuel Canet, Djamel Mokart, Frédéric Pène, Achille Kouatchet, Julien Mayaux, Martine Nyunga, Fabrice Bruneel, Antoine Rabbat, Christine Lebert, Pierre Perez, Anne Renault, Anne-Pascale Meert, Dominique Benoit, Rebecca Hamidfar, Mercé Jourdain, Benoit Schlemmer, Sylvie Chevret, Virginie Lemiale, Elie Azoulay
BACKGROUND: Cancer patients are at high risk for acute kidney injury (AKI), which is associated with high morbidity and mortality. We sought to appraise the incidence, risk factors, and outcome of AKI in a large multicentre cohort study of critically ill patients with haematological malignancies. METHODS: We used a retrospective analysis of a prospectively collected database. The study was carried out in 17 university or university-affiliated centres in France and Belgium between 2010 and 2012...
December 2015: Nephrology, Dialysis, Transplantation
Virginie Lemiale, Djamel Mokart, Matthieu Resche-Rigon, Frédéric Pène, Julien Mayaux, Etienne Faucher, Martine Nyunga, Christophe Girault, Pierre Perez, Christophe Guitton, Kenneth Ekpe, Achille Kouatchet, Igor Théodose, Dominique Benoit, Emmanuel Canet, François Barbier, Antoine Rabbat, Fabrice Bruneel, Francois Vincent, Kada Klouche, Kontar Loay, Eric Mariotte, Lila Bouadma, Anne-Sophie Moreau, Amélie Seguin, Anne-Pascale Meert, Jean Reignier, Laurent Papazian, Ilham Mehzari, Yves Cohen, Maleka Schenck, Rebecca Hamidfar, Michael Darmon, Alexandre Demoule, Sylvie Chevret, Elie Azoulay
IMPORTANCE: Noninvasive ventilation has been recommended to decrease mortality among immunocompromised patients with hypoxemic acute respiratory failure. However, its effectiveness for this indication remains unclear. OBJECTIVE: To determine whether early noninvasive ventilation improved survival in immunocompromised patients with nonhypercapnic acute hypoxemic respiratory failure. DESIGN, SETTING, AND PARTICIPANTS: Multicenter randomized trial conducted among 374 critically ill immunocompromised patients, of whom 317 (84...
October 27, 2015: JAMA: the Journal of the American Medical Association
Marc De Braekeleer, Etienne De Braekeleer, Nathalie Douet-Guilbert
In 1963, Jean Bernard, a French hematologist, opened a new chapter in hematology called geographic hematology ('Hématologie Géographique'). He distinguished two research avenues. One dealt with the differences between the various populations (ethnic hematology), the other with various environmental factors (environmental hematology). In recent years, focus has been put on analyzing the genetic susceptibility in cancer and hematological malignancies, particularly in childhood acute lymphoblastic leukemia, using specific gene or (genome-wide association study) approach...
2015: Expert Review of Anticancer Therapy
François Vincent, Soufia Ayed, Abdelaziz Bouguerba, Caroline Bornstain
No abstract text is available yet for this article.
August 2015: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
A Roux, F Gonzalez, M Roux, M Mehrad, J Menotti, J-R Zahar, V-X Tadros, E Azoulay, P-Y Brillet, F Vincent
Pneumocystis jirovecii is the only fungus of its kind to be pathogenic in humans. It is primarily responsible for pneumonia (PJP). The key to understanding immune defences has focused on T-cells, mainly because of the HIV infection epidemic. Patients presenting with PJP all have a CD4 count below 200/mm(3). The introduction of systematic primary prophylaxis and the use of new anti-retroviral drugs have significantly reduced the incidence of this disease in the HIV-infected population, mainly in developed countries...
May 2014: Médecine et Maladies Infectieuses
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