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O Naseer, J A Khan, M S Khan, M O Omer, G A Chishti, M L Sohail, M U Saleem
Aflatoxins are secondary metabolites produced by Aspergillus spp. which are injurious to animals and humans The aim of this study was to determine the effects of aflatoxin B1 (AFB1) on Average Daily Feed Intake (ADFI), Average Daily Weight Gain (ADWG), haematological and serum biochemical responses of Bovine Calves and to determine the comparative efficacy of two different liver tonics against AFB1. Twenty seven calves were selected from herd and divided into 3 groups. All calves were fed with 1.0 mg/kg AFB1 for a period of 10 days...
September 1, 2016: Polish Journal of Veterinary Sciences
Marie Bouteloup, Sophie Perinel, Aurélie Bourmaud, Elie Azoulay, Djamel Mokart, Michael Darmon
PURPOSE: Whether neutropenia has an impact on the mortality of critically ill cancer patients remains controversial, yet it is widely used as an admission criterion and prognostic factor. METHODS: Systematic review and meta-analysis. Studies on adult cancer patients and intensive care units were searched on PubMed and Cochrane databases (2005-2015). Summary estimates of mortality risk differences were calculated using the random-effects model. RESULTS: Among the 1,528 citations identified, 38 studies reporting on 6,054 patients (2,097 neutropenic patients) were included...
September 21, 2016: Oncotarget
A Dupré, C Mousseaux, A Bouguerba, S Ayed, J Barchazs, M Boukari, D Goldgran-Toledano, C Bornstain, F Vincent
Whether it appears spontaneously or is induced by therapy, the tumor lysis syndrome is responsible for a massive release of ions and puric bases degradation of products in the circulation exceeding the renal excretion capacity. Some, such as uric acid, xanthine, and calcium phosphate, can precipitate in the renal tubules or parenchyma. It must be known to any practitioner supporting patients with hematologic malignancies, mainly high-grade but also some solid tumors. The 2015 publication of the British recommendations pertaining to patients suffering from hematological diseases should be broadcast...
September 19, 2016: La Revue de Médecine Interne
(no author information available yet)
No abstract text is available yet for this article.
June 2016: Annals of Intensive Care
Benoit Champigneulle, Alain Cariou, François Vincent
No abstract text is available yet for this article.
January 2016: JAMA Internal Medicine
Michael Darmon, François Vincent, Emmanuel Canet, Djamel Mokart, Frédéric Pène, Achille Kouatchet, Julien Mayaux, Martine Nyunga, Fabrice Bruneel, Antoine Rabbat, Christine Lebert, Pierre Perez, Anne Renault, Anne-Pascale Meert, Dominique Benoit, Rebecca Hamidfar, Mercé Jourdain, Benoit Schlemmer, Sylvie Chevret, Virginie Lemiale, Elie Azoulay
BACKGROUND: Cancer patients are at high risk for acute kidney injury (AKI), which is associated with high morbidity and mortality. We sought to appraise the incidence, risk factors, and outcome of AKI in a large multicentre cohort study of critically ill patients with haematological malignancies. METHODS: We used a retrospective analysis of a prospectively collected database. The study was carried out in 17 university or university-affiliated centres in France and Belgium between 2010 and 2012...
December 2015: Nephrology, Dialysis, Transplantation
Virginie Lemiale, Djamel Mokart, Matthieu Resche-Rigon, Frédéric Pène, Julien Mayaux, Etienne Faucher, Martine Nyunga, Christophe Girault, Pierre Perez, Christophe Guitton, Kenneth Ekpe, Achille Kouatchet, Igor Théodose, Dominique Benoit, Emmanuel Canet, François Barbier, Antoine Rabbat, Fabrice Bruneel, Francois Vincent, Kada Klouche, Kontar Loay, Eric Mariotte, Lila Bouadma, Anne-Sophie Moreau, Amélie Seguin, Anne-Pascale Meert, Jean Reignier, Laurent Papazian, Ilham Mehzari, Yves Cohen, Maleka Schenck, Rebecca Hamidfar, Michael Darmon, Alexandre Demoule, Sylvie Chevret, Elie Azoulay
IMPORTANCE: Noninvasive ventilation has been recommended to decrease mortality among immunocompromised patients with hypoxemic acute respiratory failure. However, its effectiveness for this indication remains unclear. OBJECTIVE: To determine whether early noninvasive ventilation improved survival in immunocompromised patients with nonhypercapnic acute hypoxemic respiratory failure. DESIGN, SETTING, AND PARTICIPANTS: Multicenter randomized trial conducted among 374 critically ill immunocompromised patients, of whom 317 (84...
October 27, 2015: JAMA: the Journal of the American Medical Association
Marc De Braekeleer, Etienne De Braekeleer, Nathalie Douet-Guilbert
In 1963, Jean Bernard, a French hematologist, opened a new chapter in hematology called geographic hematology ('Hématologie Géographique'). He distinguished two research avenues. One dealt with the differences between the various populations (ethnic hematology), the other with various environmental factors (environmental hematology). In recent years, focus has been put on analyzing the genetic susceptibility in cancer and hematological malignancies, particularly in childhood acute lymphoblastic leukemia, using specific gene or (genome-wide association study) approach...
2015: Expert Review of Anticancer Therapy
François Vincent, Soufia Ayed, Abdelaziz Bouguerba, Caroline Bornstain
No abstract text is available yet for this article.
August 2015: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
A Roux, F Gonzalez, M Roux, M Mehrad, J Menotti, J-R Zahar, V-X Tadros, E Azoulay, P-Y Brillet, F Vincent
Pneumocystis jirovecii is the only fungus of its kind to be pathogenic in humans. It is primarily responsible for pneumonia (PJP). The key to understanding immune defences has focused on T-cells, mainly because of the HIV infection epidemic. Patients presenting with PJP all have a CD4 count below 200/mm(3). The introduction of systematic primary prophylaxis and the use of new anti-retroviral drugs have significantly reduced the incidence of this disease in the HIV-infected population, mainly in developed countries...
May 2014: Médecine et Maladies Infectieuses
J M I Vos, M C Minnema, P W Wijermans, S Croockewit, M E D Chamuleau, S T Pals, S K Klein, M Delforge, G W van Imhoff, M J Kersten
On behalf of the lymphoma and multiple myeloma working parties of the Dutch/Belgian Haemato-Oncology Foundation for Adults in The Netherlands (HOVON), we present a guideline for diagnosis and management of Waldenström's macroglobulinemia (WM). Considering the indolent behaviour and heterogeneous clinical presentation of WM, it is crucial to determine the right indications for treatment, as well as to individualise therapeutic options. There are significant differences from the approach to multiple myeloma or the treatment of other indolent non-Hodkgin lymphomas, and these results cannot always be extrapolated...
March 2013: Netherlands Journal of Medicine
F Vincent, M-A Hospital, V Lemiale, F Bruneel, M Darmon, F Gonzalez, A Kouatchet, D Mokart, F Pène, A Rabbat, Y Cohen, E Azoulay
The effective management of the respiratory manifestations at the early phase of acute myeloid hemopathies, especially acute myeloid leukaemia, frequently requires a close collaboration between hematologists, pulmonologists and intensivists. Dominated by infectious etiologies, there are however "specific" disease entities that should not be neglected in the diagnostic and therapeutic approach. These include lung leukostasis, leukemic lung infiltration, the cell lysis pneumopathy and the secondary alveolar proteinosis...
June 2012: Revue des Maladies Respiratoires
Anna Bednarek-Skublewska, Beata Jakubowska-Solarska, Janusz Solski, Andrzej Ksiazek
INTRODUCTION: Sialic acids (SA) located in erythrocyte membranes (EM) play an important role in the survival of circulating red blood cells. OBJECTIVES: The aim of the present study was to evaluate the SA content in EM obtained from patients on chronic hemodialysis (HD) and to examine the relationships between SA and hematological parameters. Moreover, the effects of HD, treatment with human recombinant erythropoetin (epoetin), and some biochemical and hematological parameters were analyzed...
April 2009: Polskie Archiwum Medycyny Wewnętrznej
Olivier Lortholary, Agnès Lefort, Michel Tod, Anne-Marie Chomat, Clémence Darras-Joly, Catherine Cordonnier
We review experimental and clinical data on the pharmacokinetics and pharmacodynamics of antibacterial drugs in febrile neutropenic hosts. Since major pharmacokinetic changes have been reported for various classes of antibiotics in these patients, we advocate the need for adequate initial dosing regimens in all cases. Monitoring drug serum concentrations is mandatory for aminoglycosides and glycopeptides, and special attention should be paid to the dosing frequency of the short half-life beta-lactams to optimise the management of febrile neutropenia, especially in patients with severe sepsis...
October 2008: Lancet Infectious Diseases
Roel G W Verhaak, Mathijs A Sanders, Maarten A Bijl, Ruud Delwel, Sebastiaan Horsman, Michael J Moorhouse, Peter J van der Spek, Bob Löwenberg, Peter J M Valk
BACKGROUND: Accurate interpretation of data obtained by unsupervised analysis of large scale expression profiling studies is currently frequently performed by visually combining sample-gene heatmaps and sample characteristics. This method is not optimal for comparing individual samples or groups of samples. Here, we describe an approach to visually integrate the results of unsupervised and supervised cluster analysis using a correlation plot and additional sample metadata. RESULTS: We have developed a tool called the HeatMapper that provides such visualizations in a dynamic and flexible manner and is available from http://www...
2006: BMC Bioinformatics
Catherine Cordonnier, Raoul Herbrecht, Agnès Buzyn, Guy Leverger, Roland Leclercq, Gérard Nitenberg, Sylvie Bastuji-Garin
BACKGROUND AND OBJECTIVES: The objective of this study was to evaluate the risk of Gram-negative bacterial infections in febrile neutropenic patients and to develop a specific risk score. DESIGN AND METHODS: This prospective study included 513 consecutive febrile neutropenic, evaluable patients. Forty-five per cent of the patients were receiving prophylactic gut decontamination, and 6% were receiving prophylactic quinolones at the onset of febrile neutropenia. Data were collected from the onset of febrile neutropenia until 30 days later...
August 2005: Haematologica
Catherine Cordonnier, Agnès Buzyn, Guy Leverger, Raoul Herbrecht, Mathilde Hunault, Roland Leclercq, Sylvie Bastuji-Garin et al.
The objective of this study was to evaluate the risk of acquiring gram-positive coccal infections in febrile neutropenic patients and to develop risk indexes for gram-positive and streptococcal infections. This prospective, multicenter study included 513 patients. The prevalence of gram-positive coccal infections was 21% (14% were staphylococcal infections and 7.8% were streptococcal infections). The mortality rate during the month after study enrollment was 5%. On multivariate analysis, the occurrence of gram-positive coccal infections was significantly associated with receipt of high-dose cytarabine therapy, proton pump inhibitors, and gut decontamination with colimycin without glycopeptides and presence of chills...
January 15, 2003: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Elizabeth J. Norman, Ronnie C. J. Barron, Andrew S. Nash, Roger BB. Clampitt
True thrombocytopenia is uncommon in cats; however, low platelet counts frequently are found using automated cell counters. Although this discrepancy is a well known problem, the prevalence of low automated platelet counts in feline blood samples has not been documented. We retrospectively compared the prevalence of low automated platelet counts with low blood smear-estimated platelet counts in feline blood samples. Results of blood sample analysis from 359 cats during a 1-year period at the University of Glasgow Veterinary Haematology Laboratory were examined...
2001: Veterinary Clinical Pathology
F Blot, C Cordonnier, A Buzin, G Nitenberg, B Schlemmer, S Bastuji-Garin et al.
OBJECTIVE: To assess the prognostic value of two severity of illness scores, commonly used for critically ill patients, Simplified Acute Physiology Score (SAPS II) and Organ Dysfunctions and Infection (ODIN), in predicting mortality in febrile neutropenic patients in hematology wards. DESIGN: A 2-month prospective multicenter study. SETTING: Thirty-six hematologic and/or stem cell transplant units in France. PATIENTS: All adult patients with a first febrile neutropenic episode (polymorphonuclear cells <500/mm(3)) were included...
November 2001: Critical Care Medicine
C Gardin, P Chaibi, T de Revel, P Rousselot, P Turlure, J M Micléa, G Nédellec, H Dombret
Using a combination of intensive chemotherapy and G-CSF, we conducted a prospective trial designed to improve the complete remission (CR) rate in patients with AML evolving from a primary documented myelodysplastic syndrome (sAML) and therapy-related AML (tAML). Thirty-four patients (median age 61 years) with sAML (25 patients) or tAML (nine patients) entered the study. Induction course consisted of idarubicin (12 mg/m2 of body-surface area per day for 3 days) and intermediate-dose (ID) cytarabine in the 24 younger patients (1 g/m2 of body-surface area as a 2 h infusion every 12 h for 5 days) or standard-dose (SD) cytarabine in the 10 older patients (100 mg/m2 of body-surface area per day as a continuous infusion for 7 days), followed by G-CSF until neutrophil recovery or treatment failure...
January 1997: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
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