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methylsulfonylmethane

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https://www.readbyqxmd.com/read/27844051/the-influence-of-methylsulfonylmethane-on-inflammation-associated-cytokine-release-before-and-following-strenuous-exercise
#1
Mariè van der Merwe, Richard J Bloomer
Background. Inflammation is associated with strenuous exercise and methylsulfonylmethane (MSM) has been shown to have anti-inflammatory properties. Methods. Physically active men were supplemented with either placebo or MSM (3 grams per day) for 28 days before performing 100 repetitions of eccentric knee extension exercise. Ex vivo and in vitro testing consisted of evaluating cytokine production in blood (whole blood and isolated peripheral blood mononuclear cells (PBMCs)) exposed to lipopolysaccharide (LPS), before and through 72 hours after exercise, while in vivo testing included the evaluation of cytokines before and through 72 hours after exercise...
2016: Journal of Sports Medicine (Hindawi Publishing Corporation)
https://www.readbyqxmd.com/read/27711089/serenoa-repens-associated-with-selenium-and-lycopene-extract-and-bromelain-and-methylsulfonylmethane-extract-are-able-to-improve-the-efficacy-of-levofloxacin-in-chronic-bacterial-prostatitis-patients
#2
Tommaso Cai, Daniele Tiscione, Luca Gallelli, Paolo Verze, Alessandro Palmieri, Vincenzo Mirone, Riccardo Bartoletti, Gianni Malossini
OBJECTIVE: To date, the management of patients with chronic bacterial prostatitis (CBP) is not satisfactory, especially in terms of symptoms relief. Here, we evaluated the efficacy and the safety of a combination of serenoa repens, selenium and lycopene extract + bromelain and methylsulfonylmethane extract associated with levofloxacin in patients with CBP. MATERIALS AND METHODS: All patients with clinical and instrumental diagnosis of CBP, admitted to a single Urological Institution from March to June 2015 were enrolled in this phase III study...
October 5, 2016: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/27621186/methylsulfonylmethane-msm-an-organosulfur-compound-is-effective-against-obesity-induced-metabolic-disorders-in-mice
#3
Inês Sousa-Lima, Shin-Young Park, Michelle Chung, Hyun Ju Jung, Min-Cheol Kang, Joana M Gaspar, Ji A Seo, M Paula Macedo, Kyong Soo Park, Christos Mantzoros, Seung-Hoon Lee, Young-Bum Kim
Methylsulfonylmethane (MSM), an organosulfur compound, has been used as a dietary supplement that can improve various metabolic diseases. However, the effect of MSM on obesity-linked metabolic disorders remains unclear. The goal of the current study is to determine whether MSM has beneficial effects on glucose and lipid homeostasis in obesity-associated pathophysiologic states. High-fat diet-induced obese (DIO) and genetically obese diabetic db/db mice treated with MSM (1%-5% v/v, by drinking water) were studied...
October 2016: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/27594189/evidence-based-evaluation-of-complementary-health-approaches-for-pain-management-in-the-united-states
#4
REVIEW
Richard L Nahin, Robin Boineau, Partap S Khalsa, Barbara J Stussman, Wendy J Weber
Although most pain is acute and resolves within a few days or weeks, millions of Americans have persistent or recurring pain that may become chronic and debilitating. Medications may provide only partial relief from this chronic pain and can be associated with unwanted effects. As a result, many individuals turn to complementary health approaches as part of their pain management strategy. This article examines the clinical trial evidence for the efficacy and safety of several specific approaches-acupuncture, manipulation, massage therapy, relaxation techniques including meditation, selected natural product supplements (chondroitin, glucosamine, methylsulfonylmethane, S-adenosylmethionine), tai chi, and yoga-as used to manage chronic pain and related disability associated with back pain, fibromyalgia, osteoarthritis, neck pain, and severe headaches or migraines...
September 2016: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/27447722/methylsulfonylmethane-inhibits-rankl-induced-osteoclastogenesis-in-bmms-by-suppressing-nf-%C3%AE%C2%BAb-and-stat3-activities
#5
Youn Hee Joung, Pramod Darvin, Dong Young Kang, Nipin Sp, Hyo Joo Byun, Chi-Ho Lee, Hak Kyo Lee, Young Mok Yang
Osteoclast differentiation is dependent on the activities of receptor activator NF-kB ligand (RANKL) and macrophage colony-stimulating factor (M-CSF). Given that RANKL plays a critical role in osteoclast formation and bone resorption, any new compounds found to alter its activity would be predicted to have therapeutic potential for disorders associated with bone loss. Methylsulfonylmethane (MSM) is a naturally occurring sulfur compound with well-documented anti-oxidant and anti-inflammatory properties; currently its effects on osteoclast differentiation are unknown...
2016: PloS One
https://www.readbyqxmd.com/read/27428957/methylsulfonylmethane-induces-p53-independent-apoptosis-in-hct-116-colon-cancer-cells
#6
Arzu Zeynep Karabay, Asli Koc, Tulin Ozkan, Yalda Hekmatshoar, Asuman Sunguroglu, Fugen Aktan, Zeliha Buyukbingol
Methylsulfonylmethane (MSM) is an organic sulfur-containing compound which has been used as a dietary supplement for osteoarthritis. MSM has been shown to reduce oxidative stress and inflammation, as well as exhibit apoptotic or anti-apoptotic effects depending on the cell type or activating stimuli. However, there are still a lot of unknowns about the mechanisms of actions of MSM. In this study, MSM was tested on colon cancer cells. 3-(4,5-Dimethylthiazol-2-yl)-2,5 diphenyltetrazolium bromide (MTT) assay and flow cytometric analysis revealed that MSM inhibited cell viability and increased apoptotic markers in both HCT-116 p53 +/+ and HCT-116 p53 -/- colon cancer cells...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27175741/methylsulfonylmethane-enhances-bmp%C3%A2-2%C3%A2-induced-osteoblast-differentiation-in-mesenchymal-stem-cells
#7
Don Nam Kim, Youn Hee Joung, Pramod Darvin, Dong Young Kang, Nipin Sp, Hyo Joo Byun, Kwang Hyun Cho, Kyung Do Park, Hak Kyo Lee, Young Mok Yang
As human lifespans have increased, the incidence of osteoporosis has also increased. Methylsulfonylmethane (MSM) affects the process of mesenchymal stem cell (MSC) differentiation into osteoblasts via the Janus kinase 2 (Jak2)/signal transducer and activator of transcription (STAT)5b signaling pathway, and bone morphogenetic protein 2 (BMP‑2) is also known to significantly affect bone health. In addition, the phosphorylation of small mothers against decapentaplegic (Smad)1/5/8 regulates the Runt‑related transcription factor 2 (Runx2) gene, which encodes a transcription factor for osteoblast differentiation markers...
July 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/26648017/methylsulfonylmethane-inhibits-her2-expression-through-stat5b-in-breast-cancer-cells
#8
Dong Young Kang, Pramod Darvin, Young Beom Yoo, Youn Hee Joung, Nipin Sp, Hyo Joo Byun, Young Mok Yang
Breast cancer is the most common cancer in women globally. The factors that increase risk include: late age at first birth, alcohol, radiation exposure, family history of breast cancer, and postmenopausal hormone therapy. Numerous drugs are being developed to treat breast cancer. Among them, Herceptin is used for the treatment of human epidermal growth factor receptor 2 (HER2)-positive cases and targets HER2 effectively and efficiently, but it is very expensive. Methylsulfonylmethane (MSM) is an organic sulfur-containing natural compound having no reported toxicity...
February 2016: International Journal of Oncology
https://www.readbyqxmd.com/read/26550817/-evaluation-of-the-combined-treatment-of-oral-viscosupplementation-with-hyaluronic-acid-intra-articular-injection-on-symptomatic-knee-osteoarthritis
#9
RANDOMIZED CONTROLLED TRIAL
E Panuccio, A Memeo, S Richetta
OBJECTIVES: Numerous clinical evidences support the treatment of knee OA (KOA) with oral formulations based on hyaluronic acid (HA) and chondroitin sulfate (CS). The formulation aim of the present study (IA) combines a hydrolyzed low molecular weight collagen matrix providing high content of depolymerised HA and CS, with methylsulfonylmethane (MSM), Manganese and a milk glycoprotein. The goal was to evaluate whether combined treatment with intra - articular injection of HA and AI is more effective than treatment with HA only for the symptomatic treatment of knee OA...
2015: La Clinica Terapeutica
https://www.readbyqxmd.com/read/26084564/the-combination-of-methylsulfonylmethane-and-tamoxifen-inhibits-the-jak2-stat5b-pathway-and-synergistically-inhibits-tumor-growth-and-metastasis-in-er-positive-breast-cancer-xenografts
#10
Nipin S P, Pramod Darvin, Young Beom Yoo, Youn Hee Joung, Dong Young Kang, Don Nam Kim, Tae Sook Hwang, Sang Yoon Kim, Wan Seop Kim, Hak Kyo Lee, Byung Wook Cho, Heui Soo Kim, Kyung Do Park, Jong Hwan Park, Soung Hoon Chang, Young Mok Yang
BACKGROUND: Combination therapy, which reduces the dosage intensity of the individual drugs while increasing their efficacy, is not a novel approach for the treatment of cancer. Methylsulfonylmethane (MSM) is an organic sulfur compound shown to act against tumor cells. Tamoxifen is a commercially available therapeutic agent for breast malignancies. METHODS: In the current study, we analyzed the combinatorial effect of MSM and tamoxifen on the suppression of ER-positive breast cancer xenograft growth and metastasis...
2015: BMC Cancer
https://www.readbyqxmd.com/read/25893035/msm-ameliorates-hiv-1-tat-induced-neuronal-oxidative-stress-via-rebalance-of-the-glutathione-cycle
#11
Seol-Hee Kim, Adam J Smith, Jun Tan, R Douglas Shytle, Brian Giunta
HIV-1 Tat protein is a key neuropathological element in HIV associated neurogcognitive disorders (HAND); a type of cognitive syndrome thought to be at least partially mediated by increased levels of brain reactive oxygen species (ROS) and nitric oxide (NO). Methylsulfonylmethane (MSM) is a sulfur-containing compound known to reduce oxidative stress. This study was conducted to determine whether administration of MSM attenuates HIV-1 Tat induced oxidative stress in mouse neuronal cells. MSM treatment significantly decreased neuronal cell NO and ROS secretion...
2015: American Journal of Translational Research
https://www.readbyqxmd.com/read/25818190/chondroprotective-effects-of-a-new-glucosamine-combination-in-rats-gene-expression-biochemical-and-histopathological-evaluation
#12
COMPARATIVE STUDY
Yilmaz Ucuncu, Nuray Celik, Cengiz Ozturk, Murat Turkoglu, Nihal Cetin, Nizamettin Kockara, Ebru Sener, Cihat Dundar, Aynur Arslan, Hasan Dogan, Nezahat Kurt, Halis Suleyman
AIMS: This study investigates the effect of a new combination of glucosamine hydrochloride, chondroitin sulfate, methylsulfonylmethane, Harpagophytum procumbens root extract (standardized to 3% harpagoside) and bromelain extract (GCMHB) on formalin-induced damage to cartilage tissue in the rat knee joint and evaluates this combination in comparison with another combination of glucosamine hydrochloride, chondroitin sulfate and methylsulfonylmethane (GKM). MATERIALS AND METHODS: Animals in the control group were injected with formalin into the knee joint (FCG)...
June 1, 2015: Life Sciences
https://www.readbyqxmd.com/read/25461402/methylsulfonylmethane-inhibits-nlrp3-inflammasome-activation
#13
Huijeong Ahn, Jeeyoung Kim, Min-Jae Lee, Young Jin Kim, Young-Wook Cho, Geun-Shik Lee
Methylsulfonylmethane (MSM) is an organosulfur compound and the health benefits associated with MSM include inflammation. Although MSM has been shown to have various physiological effects, no study has yet focused on inflammasome activation. The inflammasome is a multiprotein complex that serves as a platform for caspase 1-dependent proteolytic maturation and secretion of interleukin-1β (IL-1β). In this study, we tested the effect of MSM on inflammasome activation using mouse and human macrophages. In our results, MSM significantly attenuated NLRP3 inflammasome activation in lipopolysaccharide-primed macrophages, although it had no effect on NLCR4 or AIM2 inflammasome activation...
February 2015: Cytokine
https://www.readbyqxmd.com/read/25211405/methylsulfonylmethane-modulates-apoptosis-of-lps-ifn-%C3%AE-activated-raw-264-7-macrophage-like-cells-by-targeting-p53-bax-bcl-2-cytochrome-c-and-parp-proteins
#14
Arzu Z Karabay, Fugen Aktan, Asuman Sunguroğlu, Zeliha Buyukbingol
Methylsulfonylmethane (MSM) is a non-toxic, natural organosulfur compound, which is known to possess antioxidant and anti-inflammatory activities. In recent years, MSM has been widely used as a dietary supplement for its beneficial effects against various diseases, especially arthritis. Despite being a popular supplement product, the mechanism of action of MSM is not well known. This study was designed to investigate the effects of MSM on cytotoxic signals induced by lipopolysaccharide (LPS) and interferon-gamma (IFN-γ) in RAW 264...
December 2014: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/25170357/a-pilot-study-of-complementary-and-alternative-medicine-use-in-patients-with-fibromyalgia-syndrome
#15
Geoffrey C Wall, Linda L Krypel, Michael J Miller, Derek M Rees
UNLABELLED: Fibromyalgia syndrome (FMS) is a complex disorder, with primary symptoms of sleep disturbances, pain, and fatigue. FMS is one of the most common reasons for patient visits to a rheumatologist. Previous studies have suggested that complementary and alternative medicine (CAM) use in patients with rheumatic diseases is common, but such data specific to FMS patients is limited. OBJECTIVE: The following study sought to describe the prevalence of CAM use in a primary care practice of patients with FMS and assess whether these patients discuss CAM use with their physician, physician-extender, and/or pharmacist...
October 2007: Pharmacy Practice
https://www.readbyqxmd.com/read/24904219/randomized-controlled-trial-of-a-water-soluble-nail-lacquer-based-on-hydroxypropyl-chitosan-hpch-in-the-management-of-nail-psoriasis
#16
Franca Cantoresi, Maurizio Caserini, Antonella Bidoli, Francesca Maggio, Raffaella Marino, Claudia Carnevale, Paola Sorgi, Renata Palmieri
BACKGROUND: Nail psoriasis occurs in up to 50% of patients affected by psoriasis, with a significant impact on quality of life that leads to a real clinical need for new therapeutic options. AIM: To confirm whether the strengthening and hardening properties of the hydroxypropyl-chitosan (HPCH) nail lacquer could improve the structure of the nail plates on psoriatic nails. MATERIALS AND METHODS: A randomized, double-blind, placebo controlled, parallel-group trial was carried out to evaluate the efficacy and tolerability of a hydrosoluble nail lacquer containing HPCH, Equisetum arvense, and methylsulfonylmethane on nail psoriasis...
2014: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/24866892/chondroprotection-and-the-prevention-of-osteoarthritis-progression-of-the-knee-a-systematic-review-of-treatment-agents
#17
REVIEW
Brian Gallagher, Fotios P Tjoumakaris, Marc I Harwood, Robert P Good, Michael G Ciccotti, Kevin B Freedman
BACKGROUND: Structure-modifying medications or nutraceuticals may be an effective treatment for osteoarthritis. This study identified 12 treatments that may possess chondroprotective properties: oral glucosamine; chondroitin; nonsteroidal anti-inflammatory drugs (NSAIDs); polyunsaturated fatty acids; S-adenosylmethionine; avocado and soybean unsaponifiable fractions; methylsulfonylmethane; vitamins C, D, and E; intra-articular injections of hyaluronic acid; and platelet-rich plasma (PRP)...
March 2015: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/24575169/methylsulfonylmethane-suppresses-hepatic-tumor-development-through-activation-of-apoptosis
#18
Joo-Hyun Kim, Hye-Jun Shin, Hye-Lin Ha, Young-Ho Park, Tae-Ho Kwon, Mi-Ra Jung, Hyung-Bae Moon, Eun-Sang Cho, Hwa-Young Son, Dae-Yeul Yu
AIM: To investigate the effect of methylsulfonylmethane (MSM), recently reported to have anti-cancer effects, in liver cancer cells and transgenic mice. METHODS: Three liver cancer cell lines, HepG2, Huh7-Mock and Huh7-H-ras (G12V), were used. Cell growth was measured by Cell Counting Kit-8 and soft agar assay. Western blot analysis was used to detect caspases, poly (ADP-ribose) polymerase (PARP), and B-cell lymphoma 2 (Bcl-2) expressions. For in vivo study, we administered MSM to H-ras (12V) transgenic mice for 3 mo...
February 27, 2014: World Journal of Hepatology
https://www.readbyqxmd.com/read/24523764/effect-of-single-dose-administration-of-methylsulfonylmethane-on-oxidative-stress-following-acute-exhaustive-exercise
#19
Babak Nakhostin-Roohi, Zahra Niknam, Nasrin Vaezi, Sadollah Mohammadi, Shahab Bohlooli
Methylsulfonylmethane (MSM) is a sulfur-containing compound commonly found in diet and known to reduce oxidative stress. This trial was conducted to determine whether single dose supplementation with MSM attenuates post-exercise oxidative stress in healthy untrained young men. Sixteen untrained men volunteered for this study. Participants were randomized in a double-blind placebo-controlled fashion into 2 groups: Methylsulfonylmethane (MSM) (n = 8) and placebo (n = 8). The participants took supplementation or placebo before running on treadmill for 45 min at 75% VO2max...
2013: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/24509160/metal-chelator-combined-with-permeability-enhancer-ameliorates-oxidative-stress-associated-neurodegeneration-in-rat-eyes-with-elevated-intraocular-pressure
#20
P Liu, M Zhang, M Shoeb, D Hogan, Luosheng Tang, M F Syed, C Z Wang, G A Campbell, N H Ansari
Because as many as half of glaucoma patients on intraocular pressure (IOP)-lowering therapy continue to experience optic nerve toxicity, it is imperative to find other effective therapies. Iron and calcium ions play key roles in oxidative stress, a hallmark of glaucoma. Therefore, we tested metal chelation by means of ethylenediaminetetraacetic acid (EDTA) combined with the permeability enhancer methylsulfonylmethane (MSM) applied topically on the eye to determine if this noninvasive treatment is neuroprotective in rat optic nerve and retinal ganglion cells exposed to oxidative stress induced by elevated IOP...
April 2014: Free Radical Biology & Medicine
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