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https://www.readbyqxmd.com/read/27924409/antioxidants-reverse-the-changes-in-energy-metabolism-of-rat-brain-after-chronic-administration-of-l-tyrosine
#1
Brena P Teodorak, Giselli Scaini, Milena Carvalho-Silva, Lara M Gomes, Letícia J Teixeira, Joyce Rebelo, Samira D T De Prá, Neila Zeni, Patrícia F Schuck, Gustavo C Ferreira, Emilio L Streck
Tyrosinemia type II is a rare autosomal recessive disease caused by deficiency of hepatic tyrosine aminotransferase and is associated with neurologic and development difficulties in numerous patients. Considering that the mechanisms underlying the neurological dysfunction in hypertyrosinemic patients are poorly known and that high concentrations of tyrosine provoke mitochondrial dysfunction and oxidative stress, in the present study we investigated the in vivo influence of antioxidants (N-acetylcysteine, NAC; and deferoxamine, DFX) administration on the inhibitory effects on parameters of energy metabolism in cerebral cortex, hippocampus and striatum of rats, provoked by chronic administration of L...
December 6, 2016: Metabolic Brain Disease
https://www.readbyqxmd.com/read/27910199/reverse-phase-compatible-tlc-bioautography-for-detection-of-tyrosinase-inhibitors
#2
Paula García, I Ayelen Ramallo, Ricardo L E Furlan
INTRODUCTION: Reverse phase chromatography and bioautographic assays are key tools for natural product bioguided isolation; however, their direct coupling has not been fully achieved. OBJECTIVES: To develop a bioautographic assay to detect tyrosinase inhibitors present in complex matrices sorbed on reverse phase (RP) TLC-plates that can be used for bioguided isolation of bioactive compounds. METHODS: Enzyme gel entrapment with an amphiphilic copolymer was used for assay development...
December 2, 2016: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/27908494/simultaneous-microextraction-of-inorganic-iodine-and-iodinated-amino-acids-by-miniaturized-matrix-solid-phase-dispersion-with-molecular-sieves-and-ionic-liquids
#3
Jun Cao, Li-Qing Peng, Jing-Jing Xu, Li-Jing Du, Qi-Dong Zhang
This study presents an effective method of using miniaturized matrix solid phase dispersion (MSPD) for the microextraction of inorganic iodine and iodinated amino acids from seaweed samples. Quantification of the target analytes was performed by ultrahigh performance liquid chromatography with UV detection. Molecular sieve (SBA-15) was chosen as the dispersing adsorbent with an ionic liquid (1-dodecyl-3-methylimidazolium bromide) as the elution solvent. The experimental conditions for the MSPD, such as the type of sorbent, ratio of sorbent to sample, type and concentration of the elution solvent, and grinding time were evaluated and optimized...
November 25, 2016: Journal of Chromatography. A
https://www.readbyqxmd.com/read/27871872/biotechnological-production-of-aromatic-compounds-of-the-extended-shikimate-pathway-from-renewable-biomass
#4
Jin-Ho Lee, Volker F Wendisch
Aromatic chemicals that contain an unsaturated ring with alternating double and single bonds find numerous applications in a wide range of industries, e.g. paper and dye manufacture, as fuel additives, electrical insulation, resins, pharmaceuticals, agrochemicals, in food, feed and cosmetics. Their chemical production is based on petroleum (BTX; benzene, toluene, and xylene), but they can also be obtained from plants by extraction. Due to petroleum depletion, health compliance, or environmental issues such as global warming, the biotechnological production of aromatics from renewable biomass came more and more into focus...
November 18, 2016: Journal of Biotechnology
https://www.readbyqxmd.com/read/27864137/intergenomic-evolution-and-metabolic-cross-talk-between-rumen-and-thermophilic-autotrophic-methanogenic-archaea
#5
M Bharathi, P Chellapandi
Methanobrevibacter ruminantium M1 (MRU) is a rumen methanogenic archaean that can be able to utilize formate and CO2/H2 as growth substrates. Extensive analysis on the evolutionary genomic contexts considered herein to unravel its intergenomic relationship and metabolic adjustment acquired from the genomic content of Methanothermobacter thermautotrophicus ΔH. We demonstrated its intergenomic distance, genome function, synteny homologs and gene families, origin of replication, and methanogenesis to reveal the evolutionary relationships between Methanobrevibacter and Methanothermobacter...
November 15, 2016: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/27864061/melanogenesis-inhibits-respiration-in-b16-f10-melanoma-cells-whereas-enhances-mitochondrial-cell-content
#6
Willian Vanderlei Meira, Tassiele Andréa Heinrich, Silvia Maria Suter Correia Cadena, Glaucia Regina Martinez
Melanoma is a rare and aggressive skin tumor; the survival of patients diagnosed late is fairly low. This high mortality rate is due to the characteristics of the cells that allow them to be resistant to radiotherapy and conventional chemotherapy, besides of being able to evade the immune system. Melanin, the pigment responsible for skin, hair and eye color, seems to be involved in this resistance. The main function of melanin is to protect the cells against ultraviolet (UV) light by absorbing this radiation and reactive oxygen species (ROS) scavenging...
November 15, 2016: Experimental Cell Research
https://www.readbyqxmd.com/read/27853813/radiation-injury-vs-recurrent-brain-metastasis-combining-textural-feature-radiomics-analysis-and-standard-parameters-may-increase-18-f-fet-pet-accuracy-without-dynamic-scans
#7
Philipp Lohmann, Gabriele Stoffels, Garry Ceccon, Marion Rapp, Michael Sabel, Christian P Filss, Marcel A Kamp, Carina Stegmayr, Bernd Neumaier, Nadim J Shah, Karl-Josef Langen, Norbert Galldiks
OBJECTIVES: We investigated the potential of textural feature analysis of O-(2-[(18)F]fluoroethyl)-L-tyrosine ((18)F-FET) PET to differentiate radiation injury from brain metastasis recurrence. METHODS: Forty-seven patients with contrast-enhancing brain lesions (n = 54) on MRI after radiotherapy of brain metastases underwent dynamic (18)F-FET PET. Tumour-to-brain ratios (TBRs) of (18)F-FET uptake and 62 textural parameters were determined on summed images 20-40 min post-injection...
November 16, 2016: European Radiology
https://www.readbyqxmd.com/read/27822460/the-transcriptome-of-exophiala-dermatitidis-during-ex-vivo-skin-model-infection
#8
Caroline Poyntner, Barbara Blasi, Elsa Arcalis, Ursula Mirastschijski, Katja Sterflinger, Hakim Tafer
The black yeast Exophiala dermatitidis is a widespread polyextremophile and human pathogen, that is found in extreme natural habitats and man-made environments such as dishwashers. It can cause various diseases ranging from phaeohyphomycosis and systemic infections, with fatality rates reaching 40%. While the number of cases in immunocompromised patients are increasing, knowledge of the infections, virulence factors and host response is still scarce. In this study, for the first time, an artificial infection of an ex-vivo skin model with Exophiala dermatitidis was monitored microscopically and transcriptomically...
2016: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/27817203/chemical-composition-and-biological-activities-of-the-essential-oil-from-rubus-pungens-var-oldhamii
#9
Yaojie Zhang, Jiajing Chen, Lizhi Wang, Jingjing Cao, Lishan Xu
This paper presents a study on chemical composition, antimicrobial, antioxidant and tyrosinase inhibitory properties of the essential oil from leaves of Rubus pungens var. oldhamii (REO). The major component of the REO is sesquiterpenes (36.04%), which consists of 1,5-Cyclooctadiene,3-(1-me thylallyl)-(8CI)(17.66%), 5,6-Diethenyl-1-methylcyclohexene (12%), (+) - γ-Elemene (10.48%) and β-Caryophyllene (8.39%).The REO is shown to be moderately active against Staphylococcus aureus, Aspergillus niger and Penicillium glaucum, and has weak antioxidant activity in 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay...
November 6, 2016: Natural Product Research
https://www.readbyqxmd.com/read/27780313/synthesis-carbonic-anhydrase-i-and-ii-isoenzymes-inhibition-properties-and-antibacterial-activities-of-novel-tetralone-based-1-4-benzothiazepine-derivatives
#10
Mustafa Ceylan, Umit M Kocyigit, Necibe Canan Usta, Belma Gürbüzlü, Yusuf Temel, Saleh H Alwasel, İlhami Gülçin
Benzothiazepine compounds have a wide range of applications such as antibacterial, antidepressants, anticonvulsants, antihypertensives, antibiotics, antifungal, hypnotic, enzyme inhibitors, antitumor, anticancer and anti-HIV agents. In this study, the synthesis of novel tetralone-based benzothiazepine derivatives (1-16) and their in vitro antibacterial activity and human carbonic anhydrase isoenzymes I and II (hCA I and II) inhibitory effects were investigated. Both isoenzymes were purified by sepharose-4B-l-tyrosine-sulfanilamide affinity chromatography from fresh human red blood cells...
October 25, 2016: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/27769279/suspected-recurrence-of-brain-metastases-after-focused-high-dose-radiotherapy-can-18-f-fet-pet-overcome-diagnostic-uncertainties
#11
Alexander Romagna, Marcus Unterrainer, Christine Schmid-Tannwald, Matthias Brendel, Jörg-Christian Tonn, Silke Birgit Nachbichler, Alexander Muacevic, Peter Bartenstein, Friedrich-Wilhelm Kreth, Nathalie Lisa Albert
BACKGROUND: After focused high dose radiotherapy of brain metastases, differentiation between tumor recurrence and radiation-induced lesions by conventional MRI is challenging. This study investigates the usefulness of dynamic O-(2-(18)F-Fluoroethyl)-L-Tyrosine positron emission tomography ((18)F-FET PET) in patients with MRI-based suspicion of tumor recurrence after focused high dose radiotherapy of brain metastases. METHODS: Twenty-two patients with 34 brain metastases (median age 61...
October 21, 2016: Radiation Oncology
https://www.readbyqxmd.com/read/27754904/18f-fet-pet-uptake-characteristics-in-patients-with-newly-diagnosed-and-untreated-brain-metastasis
#12
Marcus Unterrainer, Norbert Galldiks, Bogdana Suchorska, Lara-Caroline Kowalew, Vera Wenter, Christine Schmid-Tannwald, Maximilian Niyazi, Peter Bartenstein, Karl-Josef Langen, Nathalie L Albert
PURPOSE: In patients with brain metastasis, PET using labeled amino acids has gained clinical importance, mainly regarding the differentiation of viable tumor tissue from treatment-related effects. However, there is still limited knowledge concerning the uptake characteristics in patients with newly diagnosed and untreated brain metastases. Hence, we evaluated the uptake characteristics in these patients using dynamic O-(2-(18)F-fluoroethyl)-L-tyrosine ((18)F-FET) positron-emission-tomography (PET)...
October 6, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27734607/tyrosine-based-ionic-liquid-crystals-switching-from-a-smectic-a-to-a-columnar-mesophase-by-exchange-of-the-spherical-counterion
#13
Manuel M Neidhardt, Manpreet Wolfrum, Stuart Beardsworth, Tobias Wöhrle, Wolfgang Frey, Angelika Baro, Cosima Stubenrauch, Frank Giesselmann, Sabine Laschat
Synthetic strategies were developed to prepare l-tyrosine-based ionic liquid crystals with structural variations at the carboxylic and phenolic OH groups as well as the amino functionality. Salt metathesis additionally led to counterion variation. The liquid-crystalline properties were investigated by differential scanning calorimetry (DSC), polarizing optical microscopy (POM) and X-ray diffraction (WAXS, SAXS). The symmetrical ILC chlorides bearing the same alkyl chain at both the ester and ether but either an acyclic or cyclic guanidinium group displayed enantiotropic SmA2 mesophases with phase widths of 31-88 K irrespective of the head group...
October 13, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27726859/biochemical-properties-and-subcellular-localization-of-tyrosine-aminotransferases-in-arabidopsis-thaliana
#14
Minmin Wang, Kyoko Toda, Hiroshi A Maeda
Plants produce various L-tyrosine (Tyr)-derived compounds that are of pharmaceutical or nutritional importance to humans. Tyr aminotransferase (TAT) catalyzes the reversible transamination between Tyr and 4-hydroxyphenylpyruvate (HPP), the initial step in the biosynthesis of many Tyr-derived plant natural products. Herein reported is the biochemical characterization and subcellular localization of TAT enzymes from the model plant Arabidopsis thaliana. Phylogenetic analysis showed that Arabidopsis has at least two homologous TAT genes, At5g53970 (AtTAT1) and At5g36160 (AtTAT2)...
October 7, 2016: Phytochemistry
https://www.readbyqxmd.com/read/27719910/stability-improvement-of-natural-food-colors-impact-of-amino-acid-and-peptide-addition-on-anthocyanin-stability-in-model-beverages
#15
Cheryl Chung, Thananunt Rojanasasithara, William Mutilangi, David Julian McClements
Anthocyanins are prone to chemical degradation and color fading in the presence of vitamin C. The potential of three amino acids (l-phenylalanine, l-tyrosine, l-tryptophan) and a polypeptide (ε-poly-l-lysine) in prolonging the color stability of purple carrot anthocyanins (0.025%) in model beverages (0.05% l-ascorbic acid, citric acid, pH 3.0) stored at elevated temperature (40°C/7 days) was examined. In the absence of amino acids or peptides, anthocyanin degraded at first-order reaction rate. Addition of amino acids or peptide (0...
March 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27716065/cyp79d-enzymes-contribute-to-jasmonic-acid-induced-formation-of-aldoximes-and-other-nitrogenous-volatiles-in-two-erythroxylum-species
#16
Katrin Luck, Jan Jirschitzka, Sandra Irmisch, Meret Huber, Jonathan Gershenzon, Tobias G Köllner
BACKGROUND: Amino acid-derived aldoximes and nitriles play important roles in plant defence. They are well-known as precursors for constitutive defence compounds such as cyanogenic glucosides and glucosinolates, but are also released as volatiles after insect feeding. Cytochrome P450 monooxygenases (CYP) of the CYP79 family catalyze the formation of aldoximes from the corresponding amino acids. However, the majority of CYP79s characterized so far are involved in cyanogenic glucoside or glucosinolate biosynthesis and only a few have been reported to be responsible for nitrogenous volatile production...
October 4, 2016: BMC Plant Biology
https://www.readbyqxmd.com/read/27714209/bifunctional-aryloxyphosphoramidate-prodrugs-of-2-c-me-uridine-synthesis-and-anti-hcv-activity
#17
Munmun Maiti, Ling-Jie Gao, Chunsheng Huang, Roger G Ptak, Michael G Murray, Steven De Jonghe, Piet Herdewijn
In an attempt to identify novel nucleoside phosphoramidate analogues for improving the anti-HCV activity of 2'-C-Me-uridine, we have synthesized for the first time a series of l-glutamic acid, l-serine, l-threonine and l-tyrosine containing aryloxyphosphoramidate prodrugs of 2'-C-Me-uridine. Evaluation of their activity against HCV revealed that they displayed very potent anti-HCV activity, with EC50 values that are in the same range as of Sofosbuvir.
September 21, 2016: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/27711193/effective-l-tyrosine-hydroxylation-by-native-and-immobilized-tyrosinase
#18
Małgorzata Cieńska, Karolina Labus, Marcin Lewańczuk, Tomasz Koźlecki, Jolanta Liesiene, Jolanta Bryjak
Hydroxylation of L-tyrosine to 3,4-dihydroxyphenylalanine (L-DOPA) by immobilized tyrosinase in the presence of ascorbic acid (AH2), which reduces DOPA-quinone to L-DOPA, is characterized by low reaction yields that are mainly caused by the suicide inactivation of tyrosinase by L-DOPA and AH2. The main aim of this work was to compare processes with native and immobilized tyrosinase to identify the conditions that limit suicide inactivation and produce substrate conversions to L-DOPA of above 50% using HPLC analysis...
2016: PloS One
https://www.readbyqxmd.com/read/27698368/-ramassays-synergistic-enhancement-of-plasmon-free-raman-scattering-and-mass-spectrometry-for-multimodal-analysis-of-small-molecules
#19
Ivano Alessandri, Irene Vassalini, Michela Bertuzzi, Nicolò Bontempi, Maurizio Memo, Alessandra Gianoncelli
SiO2/TiO2 core/shell (T-rex) beads were exploited as "all-in-one" building-block materials to create analytical assays that combine plasmon-free surface enhanced Raman scattering (SERS) and surface assisted laser desorption/ionization (SALDI) mass spectrometry (RaMassays). Such a multi-modal approach relies on the unique optical properties of T-rex beads, which are able to harvest and manage light in both UV and Vis range, making ionization and Raman scattering more efficient. RaMassays were successfully applied to the detection of small (molecular weight, M...
October 4, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27685539/synthesis-and-composition-of-amino-acid-linking-groups-conjugated-to-compounds-used-for-the-targeted-imaging-of-tumors-a-patent-evaluation-of-us20160011199a1
#20
Jean-Yves Winum
The present patent discloses the identification of small-molecule fluorescent probes constituted by pteroic acid moiety connected to near-infrared (NIR) dye via amino acids. These folate receptor (FR) targeted conjugates were shown to have high affinity for tumors that overexpress FRs. A selected compound from this new class, pteroyl-L-tyrosine-S0456 (OTL-0038), displays high affinity and specificity for FRs and was shown (i) to accumulate in vivo in tumor cells expressing FRs, and (ii) to be non-toxic in mice at clinical dose x 1000...
October 4, 2016: Expert Opinion on Therapeutic Patents
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