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https://www.readbyqxmd.com/read/29052111/targeted-massively-parallel-sequencing-characterises-the-mutation-spectrum-of-palb2-in-breast-and-ovarian-cancer-cases-from-poland-and-ukraine
#1
Aleksander Myszka, Tu Nguyen-Dumont, Pawel Karpinski, Maria M Sasiadek, Hayane Akopyan, Fleur Hammet, Helen Tsimiklis, Daniel J Park, Bernard J Pope, Ryszard Slezak, Nataliya Kitsera, Aleksandra Siekierzynska, Melissa C Southey
Loss-of-function germline mutations in the PALB2 gene are associated with an increase of breast cancer risk. The purpose of this study was to characterise the spectrum of PALB2 mutations in women affected with breast or ovarian cancer from South-West Poland and West Ukraine. We applied Hi-Plex, an amplicon-based enrichment method for targeted massively parallel sequencing, to screen the coding exons and proximal intron-exon junctions of PALB2 in germline DNA from unrelated women affected with breast cancer (n = 338) and ovarian cancer (n = 89) from Poland (n = 304) and Ukraine (n = 123)...
October 19, 2017: Familial Cancer
https://www.readbyqxmd.com/read/29052107/aspects-of-morality-and-law-enforcement-in-today-s-science-in-post-soviet-countries
#2
Jana Kliestikova, Tomas Kliestik, Maria Misankova, Tatiana Corejova, Anna Krizanova
Many reports independently confirm that even more than a quarter of a century after the collapse of the Soviet Union, the results of research and development in those countries that were under its influence are insufficient in comparison to the rest of the world. Given that human intelligence is not distributed unevenly and that science is a powerful driving force for the future of an economy, there is a hidden problem, which, if it can be resolved, may release great economic potential. The first generation of researchers from Armenia, Czech Republic, Georgia, Slovakia and Ukraine, who successfully completed their education after the political revolution, were surveyed...
October 20, 2017: Science and Engineering Ethics
https://www.readbyqxmd.com/read/29040167/country-of-birth-of-children-with-diagnosed-hiv-infection-in-the-united-states-2008-2014
#3
Steven R Nesheim, Laurie Linley, Kristen Mahle Gray, Tianchi Zhang, Jing Shi, Margaret A Lampe, Lauren F FitzHarris
BACKGROUND: Diagnoses of HIV infection among children in the United States (US) have been declining; however, a notable percentage of diagnoses are among those born outside the United States. The impact of foreign birth among children with diagnosed infections has not been examined in the United States. METHOD: Using the CDC National HIV Surveillance System, we analyzed data for children aged <13 years with diagnosed HIV infection ("children") in the United States (reported from 50 states and the District of Columbia) during 2008-2014, by place of birth and selected characteristics...
October 14, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29017524/chronic-obstructive-pulmonary-disease-bronchial-asthma-and-allergic-rhinitis-in-the-adult-population-within-the-commonwealth-of-independent-states-rationale-and-design-of-the-core-study
#4
Yuriy Feshchenko, Liudmila Iashyna, Damilya Nugmanova, Olga Gyrina, Marina Polyanskaya, Alexander Markov, Maryna Moibenko, Janina Makarova, Luqman Tariq, Marcelo Horacio S Pereira, Elcan Mammadbayov, Irada Akhundova, Averyan Vasylyev
BACKGROUND: Main treatable Chronic Respiratory Diseases (CRDs) like Chronic Obstructive Pulmonary Disease (COPD), Bronchial Asthma (BA) and Allergic Rhinitis (AR) are underdiagnosed and undertreated worldwide. CORE study was aimed to assess the point prevalence of COPD, BA and AR in the adult population of major cities of Commonwealth of Independent States (CIS) countries - Azerbaijan, Kazakhstan, and Ukraine based on study questionnaires and/or spirometry, and to document risk factors, characterize the COPD, BA and AR population to provide a clearer "epidemiological data"...
October 10, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28983984/predictors-of-aging-based-on-the-analysis-of-heart-rate-variability
#5
Nataliia Botsva, Iryna Naishtetik, Ludmyla Khimion, Dmitriy Chernetchenko
BACKGROUND: The current significant progress in the use of heart rate variability in the solution of many diagnostic and therapeutic problems is determined by the availability of standardized methods of measurement and physiological interpretation of heart rate variability indices on the one hand and the high technological level of state-of-the-art electronic measuring equipment that is used for automatic registration and computer processing of cardio-signals. METHODS: A retrospective analysis of anonymized cardio screening results of 22,433 adult residents of 565 settlements (cities and villages) across all 20 administrative districts of the Khmelnytskyi Region (Ukraine) was conducted to find a statistically significant connection between individual heart rate variability parameters and the age of people...
October 6, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28974479/prenatal-and-postnatal-pcb-153-and-p-p-dde-exposures-and-behavior-scores-at-5-9-years-of-age-among-children-in-greenland-and-ukraine
#6
Aske Hess Rosenquist, Birgit Bjerre Høyer, Jordi Julvez, Jordi Sunyer, Henning Sloth Pedersen, Virissa Lenters, Bo A G Jönsson, Jens Peter Bonde, Gunnar Toft
BACKGROUND: Studies have reported some evidence of adverse effects of organochlorine exposures on child development, but the results have been inconsistent, and few studies have evaluated associations with child behavior. OBJECTIVE: We investigated the association between prenatal and early-life exposures to 2,2',4,4',5,5'-hexachlorobiphenyl (PCB-153) and 1,1-dichloro-2,2-bis(p-chlorophenyl)-ethylene (p,p'-DDE) and behaviors in children between 5 and 9 y of age...
October 3, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28974278/the-taxonomic-and-phylogenetic-status-of-digeneans-from-the-genus-timoniella-digenea-cryptogonimidae-in-the-black-and-baltic-seas
#7
Y Kvach, A Bryjová, P Sasal, H M Winkler
Timoniella spp. are cryptogonimid flukes (Digenea: Cryptogonimidae) that parasitize the guts of fish in brackish waters. Timoniella imbutiforme, a species from the Mediterranean Sea, is recorded in the Black Sea, while T. balthica has been described from the Baltic Sea. In this paper, we clarify the taxonomic status of Timoniella populations in the Baltic and Black seas. Adults and metacercariae of Timoniella spp. were sampled from localities in the Mediterranean Sea (France), Black Sea (Ukraine) and Baltic Sea (Germany) and subjected to molecular and morphological analysis, including Bayesian phylogenetic reconstruction based on concatenated sequences of ITS1-ITS2-28S...
October 4, 2017: Journal of Helminthology
https://www.readbyqxmd.com/read/28968809/the-worldwide-incidence-and-prevalence-of-systemic-lupus-erythematosus-a-systematic-review-of-epidemiological-studies
#8
Frances Rees, Michael Doherty, Matthew J Grainge, Peter Lanyon, Weiya Zhang
Objectives: The aim was to review the worldwide incidence and prevalence of SLE and variation with age, sex, ethnicity and time. Methods: A systematic search of MEDLINE and EMBASE search engines was carried out using Medical Subject Headings and keyword search terms for Systemic Lupus Erythematosus combined with incidence, prevalence and epidemiology in August 2013 and updated in September 2016. Author, journal, year of publication, country, region, case-finding method, study period, number of incident or prevalent cases, incidence (per 100 000 person-years) or prevalence (per 100 000 persons) and age, sex or ethnic group-specific incidence or prevalence were collected...
August 9, 2017: Rheumatology
https://www.readbyqxmd.com/read/28967644/umbilical-cord-blood-banking-in-the-worldwide-hematopoietic-stem-cell-transplantation-system-perspectives-for-ukraine
#9
T O Kalynychenko
Significant progress in the promotion of procedural technologies associated with the transplantation of hematopoietic stem cells caused a rapid increase in activity. The exchange of hematopoietic stem cells for unrelated donor transplantations is now much easier due to the relevant international professional structures and organizations established to support cooperation and standard setting, as well as rules for the functioning of both national donor registries and cord blood banks. These processes are increasing every year and are contributing to the outpacing rates of development in this area...
September 2017: Experimental Oncology
https://www.readbyqxmd.com/read/28967634/scientific-practical-and-legal-problems-of-implementation-of-the-personalized-medicine
#10
N O Bezdieniezhnykh, V V Reznikova, O V Rossylna
The article is devoted to the comprehensive analysis of scientific, practical and legal issues of personalized medicine that is a rapidly developing science-driven approach to healthcare. It is concluded that there is lack of general legal framework for the encouragement of scientific researches and practical implementation in this field. The article shows foreign experience and prospects for the introduction of personalized medicine as a key concept of healthcare system, which is based on a selection of diagnostic, therapeutic and preventive measures that would be the most effective for a particular person in view of individual characteristics...
September 2017: Experimental Oncology
https://www.readbyqxmd.com/read/28966755/premenstrual-syndrome-symptomatic-and-diagnosed-prevalence-dualistic-treatment-approach-a-cross-sectional-study-in-ukraine
#11
Edith Meszaros Crow, Emilien Jeannot
BACKGROUND: Diagnosing and treatment of premenstrual syndrome (PMS) still pose a challenge in the routine medical practice which usually focuses on single pharmacological therapy. Recent research suggests that the combination of treatments including complementary alternative medicine (CAM) therapies may be more beneficial. The objective of this study was to assess the percentage of diagnosed and nondiagnosed PMS/premenstrual dysphoric disorder (PMDD) based on the presence of adequate symptoms and to compare population using hormonal or pharmaceutical agents versus CAM therapies...
2017: International Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28961466/central-nervous-system-tumours-among-adolescents-and-young-adults-15-39-years-in-southern-and-eastern-europe-registration-improvements-reveal-higher-incidence-rates-compared-to-the-us
#12
Marios K Georgakis, Paraskevi Panagopoulou, Paraskevi Papathoma, Athanasios Tragiannidis, Anton Ryzhov, Snezana Zivkovic-Perisic, Sultan Eser, Łukasz Taraszkiewicz, Mario Sekerija, Tina Žagar, Luis Antunes, Anna Zborovskaya, Joana Bastos, Margareta Florea, Daniela Coza, Anna Demetriou, Domenic Agius, Rajko M Strahinja, Georgios Sfakianos, Ioannis Nikas, Sofia Kosmidis, Evangelia Razis, Apostolos Pourtsidis, Maria Kantzanou, Nick Dessypris, Eleni Th Petridou
AIM: To present incidence of central nervous system (CNS) tumours among adolescents and young adults (AYAs; 15-39 years) derived from registries of Southern and Eastern Europe (SEE) in comparison to the Surveillance, Epidemiology and End Results (SEER), US and explore changes due to etiological parameters or registration improvement via evaluating time trends. METHODS: Diagnoses of 11,438 incident malignant CNS tumours in AYAs (1990-2014) were retrieved from 14 collaborating SEE cancer registries and 13,573 from the publicly available SEER database (1990-2012)...
September 26, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28957756/using-nominal-group-technique-among-clinical-providers-to-identify-barriers-and-prioritize-solutions-to-scaling-up-opioid-agonist-therapies-in-ukraine
#13
Lynn Madden, Martha J Bojko, Scott Farnum, Alyona Mazhnaya, Tatiana Fomenko, Ruthanne Marcus, Declan Barry, Irina Ivanchuk, Viktor Kolomiets, Sergey Filippovych, Sergey Dvoryak, Frederick L Altice
BACKGROUND: Opioid agonist therapies (OAT) like methadone and buprenorphine maintenance treatment remain markedly under-scaled in Ukraine despite adequate funding. Clinicians and administrators were assembled as part of an implementation science strategy to scale-up OAT using the Network for Improvement of Addiction Treatment (NIATx) approach. METHODS: Nominal Group Technique (NGT), a key ingredient of the NIATx toolkit, was directed by three trained coaches within a learning collaborative of 18 OAT clinicians and administrators to identify barriers to increase OAT capacity at the regional "oblast" level, develop solutions, and prioritize local change projects...
September 25, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28957479/doctor-s-enquiry-an-opportunity-for-promoting-smoking-cessation-findings-from-global-adult-tobacco-surveys-in-europe
#14
Banu Çakir, Ayse Tas, Tugçe Mehlika Sanver, Dilek Aslan
Background: Evidence suggests that advice from motivated physicians to their smoking patients is effective in promoting smoking cessation. Yet, detection rate of smokers is often low and, the proportion of smokers receiving special advice to quit varies. This study aimed to detect how frequently European physicians enquire about their patients' smoking status, and to compare and contrast how (if any) smokers benefit from physicians' enquiry and/or advice about smoking cessation. Methods: The study was based on secondary analysis of data from six European countries that conducted Global Adult Tobacco Survey, namely, Greece, Poland, Romania, Russia, Turkey and Ukraine...
October 1, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/28955109/source-regions-of-ragweed-pollen-arriving-in-south-western-poland-and-the-influence-of-meteorological-data-on-the-hysplit-model-results
#15
Daria Bilińska, Carsten Ambelas Skjøth, Małgorzata Werner, Maciej Kryza, Małgorzata Malkiewicz, Justyna Krynicka, Anetta Drzeniecka-Osiadacz
We have investigated the relationship between the inflow of air masses and the ragweed pollen concentration in SW Poland (Wrocław) for a 10-year period of 2005-2014. The HYSPLIT trajectory model was used to verify whether episodes of high concentrations can be related to regions outside of the main known ragweed centres in Europe, like Pannonian Plain, northern Italy and Ukraine. Furthermore, we used two different meteorological data sets (the global GDAS data set and from the WRF mesoscale model; the meteorological parameters were: U and V wind components, temperature and relative humidity) into HYSPLIT to evaluate the influence of meteorological input on calculated trajectories for high concentration ragweed episodes...
2017: Aerobiologia
https://www.readbyqxmd.com/read/28942704/why-people-who-inject-drugs-voluntarily-transition-off-methadone-in-ukraine
#16
Julia Rozanova, Ruthanne Marcus, Faye S Taxman, Martha J Bojko, Lynn Madden, Scott O Farnum, Alyona Mazhnaya, Sergii Dvoriak, Frederick L Altice
Methadone maintenance therapy (MMT) treats opioid use disorder among people who inject drugs (PWID). To understand why PWID may voluntarily discontinue MMT, we analyzed data from 25 focus groups conducted in five Ukrainian cities from February to April 2013 with 199 participants who were currently, previously, or never on MMT. Using constant comparison method, we uncovered three themes explaining why PWID transition off MMT: (a) purposeful resistance to rigid social control associated with how MMT is delivered and to power asymmetries in provider-patient relationships, (b) self-management of a PWID's "wounded identity" that is common in socially stigmatized and physically sick persons-MMT serves as a reminder of their illness, and (c) the quest for a "normal life" uninterrupted by daily MMT site visits, harassment, and time inefficiencies, resources, and social capital...
September 1, 2017: Qualitative Health Research
https://www.readbyqxmd.com/read/28938142/insulin-regimens-and-glycemic-control-in-different-parts-of-europe-over-4years-after-starting-insulin-in-people-with-type-2-diabetes-data-from-the-credit-non-interventional-study
#17
Lawrence Blonde, Michel Marre, Maya Vincent, Sandrine Brette, Valerie Pilorget, Nicholas Danchin, Giacomo Vespasiani, Philip Home
AIMS: A number of insulin regimens are used in type 2 diabetes. This analysis aims to better understand the evolution of insulin therapy in different regions of Europe. METHODS: Data from people starting any insulin were collected in eastern Europe (EEur: Croatia, Russia, Ukraine), northern Europe (NEur: Finland, Germany, UK) and southern Europe (SEur: France, Italy, Portugal, Spain). Retrospective data on starting insulin and prospective follow-up data were extracted from clinical records...
August 31, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28933750/iodine-intake-through-processed-food-case-studies-from-egypt-indonesia-the-philippines-the-russian-federation-and-ukraine-2010-2015
#18
Jacky Knowles, Frits van der Haar, Magdy Shehata, Gregory Gerasimov, Bimo Bimo, Bettina Cavenagh, Cherry C Maramag, Edward Otico, Doddy Izwardy, Rebecca Spohrer, Greg S Garrett
The current performance indicator for universal salt iodisation (USI) is the percentage of households using adequately iodised salt. However, the proportion of dietary salt from household salt is decreasing with the increase in consumption of processed foods and condiments globally. This paper reports on case studies supported by the Global Alliance for Improved Nutrition (GAIN)-UNICEF USI Partnership Project to investigate processed food industry use of adequately iodised salt in contrasting national contexts...
July 26, 2017: Nutrients
https://www.readbyqxmd.com/read/28929329/somatic-health-effects-of-chernobyl-30-years-on
#19
REVIEW
Maureen Hatch, Elisabeth Cardis
2016 marked the 30th anniversary of the Chernobyl Nuclear Power Plant accident. We and others wrote reviews for the 25th anniversary. Since then, additional papers have appeared and it seems timely to highlight lessons learned. To present, not a systematic review, but a commentary drawing attention to notable findings. We include not only recent reports and updates on previous results, but key findings from prior Chernobyl studies. The dose-dependent increase in Papillary Thyroid Cancer (PTC) following childhood I-131 exposure in Ukraine and Belarus has now been shown to persist for decades...
September 19, 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/28921396/determination-of-dominant-sources-of-nitrate-contamination-in-transboundary-russian-federation-ukraine-catchment-with-heterogeneous-land-use
#20
Y Vystavna, D Diadin, V Grynenko, V Yakovlev, Y Vergeles, F Huneau, P M Rossi, J Hejzlar, K Knöller
Nitrate contamination of surface water and shallow groundwater was studied in transboundary (Russia/Ukraine) catchment with heterogeneous land use. Dominant sources of nitrate contamination were determined by applying a dual δ (15)N-NO3 and δ (18)O-NO3 isotope approach, multivariate statistics, and land use analysis. Nitrate concentration was highly variable from 0.25 to 22 mg L(-1) in surface water and from 0.5 to 100 mg L(-1) in groundwater. The applied method indicated that sewage to surface water and sewage and manure to groundwater were dominant sources of nitrate contamination...
September 18, 2017: Environmental Monitoring and Assessment
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