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https://www.readbyqxmd.com/read/29461227/-the-differentiated-approach-to-prevention-of-neural-tube-defects-in-children
#1
N Kotova, V Maichuk, O Fedorenko
Neural tube defects occupy second place in frequency after the defects of the cardiovascular system. The folate metabolism violation and hyperhomocysteinemia in women are proved to be the leading risk factors for the NTD of the fetus. Polymorphism of the 5,10-methylenetetrahydrofolate reductase gene (MTHFR) is a genetic determinant of folate metabolism violation. Admission of folic acid in a standard dose of 0.4 mg and / or the use of fortified foods does not allow reaching the protective level of folic acid if there is a mutation of the MTHFR gene or when several risk factors combine, which requires a higher dose of folic acid...
January 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29459256/evaluation-of-data-quality-at-the-national-cancer-registry-of-ukraine
#2
Anton Ryzhov, Freddie Bray, Jacques Ferlay, Zoya Fedorenko, Liudmyla Goulak, Yevgeniy Gorokh, Olena Soumkina, Ariana Znaor
BACKGROUND: Cancer notification has been mandatory in Ukraine since 1953, with the National Cancer Registry of Ukraine (NCRU) established in 1996. The aim of this study was to provide a comprehensive evaluation of the data quality at the NCRU. METHODS: Qualitative and semi-quantitative methods were used to assess the comparability, completeness, validity and timeliness of cancer incidence data from the NCRU for the period 2002-2012. RESULTS: Cancer registration procedures at the NCRU are in accordance with international standards and recommendations...
February 16, 2018: Cancer Epidemiology
https://www.readbyqxmd.com/read/29455562/spatiotemporal-characteristics-of-the-hiv-1-crf02_ag-crf63_02a1-epidemic-in-russia-and-central-asia
#3
Evangelia-Georgia Kostaki, Timokratis Karamitros, Marina Bobkova, Martha Oikonomopoulou, Gkikas Magiorkinis, Federico Garcia, Angelos Hatzakis, Dimitrios Paraskevis
BACKGROUND: Eastern European countries including Russia, Ukraine and other former Soviet Union (FSU) countries have experienced an HIV epidemic spreading mostly among people who inject drugs (PWID). We aimed to investigate the origin and the dispersal patterns of HIV-1 CRF02_AG in Russia and other FSU countries. METHODS: We studied 136 CRF02_AG sequences originating from Russia, and FSU countries along with a globally sampled dataset of 3,580 CRF02_AG sequences...
February 17, 2018: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/29453023/implications-of-altered-maternal-cytokine-concentrations-on-infant-outcomes-in-children-with-prenatal-alcohol-exposure
#4
K D Sowell, J Y Uriu-Adams, J Van de Water, C D Chambers, C D Coles, J A Kable, L Yevtushok, N Zymak-Zakutnya, W Wertelecki, C L Keen
Excessive alcohol consumption has been shown to increase serum plasma levels of numerous immune cytokines. Maternal immune activation and elevated cytokines have been implicated in certain neurological disorders (e.g., autism and schizophrenia) in the offspring. We investigated the hypothesis that elevated cytokines during pregnancy are a risk factor in women who gave birth to a child with Fetal Alcohol Spectrum Disorder (FASD) or a child with neurobehavioral impairment, regardless of prenatal alcohol exposure...
August 12, 2017: Alcohol
https://www.readbyqxmd.com/read/29428166/direct-healthcare-cost-of-schizophrenia-european-overview
#5
G Kovács, T Almási, A Millier, M Toumi, M Horváth, Kristóf Kóczián, Á Götze, Z Kaló, A T Zemplényi
PURPOSE: To provide an overview on the magnitude of the impact of schizophrenia on the healthcare system in Europe and to gain a better understanding on the most important factors influencing the variation of costs. METHODS: Studies reporting costs and healthcare utilization among patients with schizophrenia were searched in MEDLINE (via Scopus), EMBASE (via Scopus) and Cochrane Database of Systematic Reviews on 19th January 2017. RESULTS: Twenty-three studies, from the 1075 references initially identified, were included in this review...
February 2018: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/29423210/the-european-renal-association-european-dialysis-and-transplant-association-era-edta-registry-annual-report-2015-a-summary
#6
Anneke Kramer, Maria Pippias, Marlies Noordzij, Vianda S Stel, Nikolaos Afentakis, Patrice M Ambühl, Anton M Andrusev, Emma Arcos Fuster, Federico E Arribas Monzón, Anders Åsberg, Myftar Barbullushi, Marjolein Bonthuis, Fergus J Caskey, Pablo Castro de la Nuez, Harijs Cernevskis, Jean-Marin des Grottes, Liliana Garneata, Eliezer Golan, Marc H Hemmelder, Kyriakos Ioannou, Faical Jarraya, Mykola Kolesnyk, Kirill Komissarov, Mathilde Lassalle, Fernando Macario, Beatriz Mahillo-Duran, Angel L Martín de Francisco, Runolfur Palsson, Ülle Pechter, Halima Resic, Boleslaw Rutkowski, Carmen Santiuste de Pablos, Nurhan Seyahi, Sanja Simic Ogrizovic, María F Slon Roblero, Viera Spustova, Olivera Stojceva-Taneva, Jamie Traynor, Ziad A Massy, Kitty J Jager
Background: This article summarizes the European Renal Association - European Dialysis and Transplant Association (ERA-EDTA) Registry's 2015 Annual Report. It describes the epidemiology of renal replacement therapy (RRT) for end-stage renal disease (ESRD) in 2015 within 36 countries. Methods: In 2016 and 2017, the ERA-EDTA Registry received data on patients who were undergoing RRT for ESRD in 2015, from 52 national or regional renal registries. Thirty-two registries provided individual patient-level data and 20 provided aggregated-level data...
February 2018: Clinical Kidney Journal
https://www.readbyqxmd.com/read/29422452/population-size-estimation-of-gay-and-bisexual-men-and-other-men-who-have-sex-with-men-using-social-media-based-platforms
#7
Stefan Baral, Rachael M Turner, Carrie E Lyons, Sean Howell, Brian Honermann, Alex Garner, Robert Hess, Daouda Diouf, George Ayala, Patrick S Sullivan, Greg Millett
BACKGROUND: Gay, bisexual, and other cisgender men who have sex with men (GBMSM) are disproportionately affected by the HIV pandemic. Traditionally, GBMSM have been deemed less relevant in HIV epidemics in low- and middle-income settings where HIV epidemics are more generalized. This is due (in part) to how important population size estimates regarding the number of individuals who identify as GBMSM are to informing the development and monitoring of HIV prevention, treatment, and care programs and coverage...
February 8, 2018: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/29417879/-pure-drug-users-commercial-sex-workers-and-ordinary-girls-gendered-narratives-of-hiv-risk-and-prevention-in-post-soviet-ukraine
#8
Jill Owczarzak, Sarah D Phillips, Woojeong Cho
International best practices call for a gender-responsive approach to HIV prevention for women, including those who use drugs and those who engage in sex work. This paper draws on multiple qualitative data sources collected over five years in Ukraine to explore the notions of gender, women and family that buttress HIV-related programmes for women. Our analysis reveals that service providers often cast women as hapless victims of unfortunate family circumstances and troubled personal relationships that produce sudden poverty, or social strivers who seek access to wealth and privilege at the expense of their health...
February 8, 2018: Culture, Health & Sexuality
https://www.readbyqxmd.com/read/29417217/dew-point-temperature-affects-ascospore-release-of-allergenic-genus-leptosphaeria
#9
Magdalena Sadyś, Joanna Kaczmarek, Agnieszka Grinn-Gofron, Victoria Rodinkova, Alex Prikhodko, Elena Bilous, Agnieszka Strzelczak, Robert J Herbert, Malgorzata Jedryczka
The genus Leptosphaeria contains numerous fungi that cause the symptoms of asthma and also parasitize wild and crop plants. In search of a robust and universal forecast model, the ascospore concentration in air was measured and weather data recorded from 1 March to 31 October between 2006 and 2012. The experiment was conducted in three European countries of the temperate climate, i.e., Ukraine, Poland, and the UK. Out of over 150 forecast models produced using artificial neural networks (ANNs) and multivariate regression trees (MRTs), we selected the best model for each site, as well as for joint two-site combinations...
January 27, 2018: International Journal of Biometeorology
https://www.readbyqxmd.com/read/29415856/a-qualitative-assessment-of-attitudes-about-and-preferences-for-extended-release-naltrexone-a-new-pharmacotherapy-to-treat-opioid-use-disorders-in-ukraine
#10
Ruthanne Marcus, Martha J Bojko, Alyona Mazhnaya, Iuliia Makarenko, Sergii Filippovych, Sergii Dvoriak, Frederick L Altice, Sandra A Springer
Numerous individual barriers, including negative attitudes toward opioid agonist therapies (OAT), have undermined HIV prevention efforts in Ukraine where the epidemic is concentrated in people who inject drugs (PWID). The recent availability of extended-release naltrexone (XR-NTX), an opioid antagonist, provides new opportunities for treatment and prevention, but little is known about patient preferences. We conducted qualitative analysis using focus groups (FG) of PWID recruited based on OAT experience: currently, previously, and never on OAT in five Ukrainian cities...
March 2018: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/29398043/preventive-radioecological-assessment-of-territory-for-optimization-of-monitoring-and-countermeasures-after-radiation-accidents
#11
B S Prister, V D Vinogradskaya, T D Lev, M M Talerko, E K Garger, Y Onishi, O G Tischenko
A methodology of a preventive radioecological assessment of the territory has been developed for optimizing post-emergency monitoring and countermeasure implementation in an event of a severe radiation accident. Approaches and main stages of integrated radioecological zoning of the territory are described. An algorithm for the assessment of the potential radioecological criticality (sensitivity) of the area is presented. The proposed approach is validated using data of the dosimetric passportization in Ukraine after the Chernobyl accident for the test site settlements...
February 2, 2018: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/29389951/molecular-epidemiology-of-hiv-1-subtype-a-in-former-soviet-union-countries
#12
Lazzat Aibekova, Brian Foley, Gonzalo Hortelano, Muhammad Raees, Sabit Abdraimov, Rakhmanbek Toichuev, Syed Ali
While in other parts of the world it is on decline, incidence of HIV infection continues to rise in the former Soviet Union (FSU) countries. The present study was conducted to investigate the patterns and modes of HIV transmission in FSU countries. We performed phylogenetic analysis of publicly available 2705 HIV-1 subtype A pol sequences from thirteen FSU countries: Armenia, Azerbaijan, Belarus, Estonia, Georgia, Kazakhstan, Kyrgyzstan, Latvia, Lithuania, Moldova, Russia, Ukraine and Uzbekistan. Our analysis showed that the clusters from FSU countries were intermixed, indicating a possible role of transmigration in HIV transmission...
2018: PloS One
https://www.readbyqxmd.com/read/29382317/the-prevalence-burden-and-risk-factors-associated-with-chronic-obstructive-pulmonary-disease-in-commonwealth-of-independent-states-ukraine-kazakhstan-and-azerbaijan-results-of-the-core-study
#13
Damilya Nugmanova, Yuriy Feshchenko, Liudmyla Iashyna, Olga Gyrina, Kateryna Malynovska, Eljan Mammadbayov, Irada Akhundova, Nadezhda Nurkina, Luqman Tariq, Janina Makarova, Averyan Vasylyev
No abstract text is available yet for this article.
January 30, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29381702/long-term-trends-in-mortality-and-aids-defining-events-after-combination-art-initiation-among-children-and-adolescents-with-perinatal-hiv-infection-in-17-middle-and-high-income-countries-in-europe-and-thailand-a-cohort-study
#14
Ali Judd, Elizabeth Chappell, Anna Turkova, Sophie Le Coeur, Antoni Noguera-Julian, Tessa Goetghebuer, Katja Doerholt, Luisa Galli, Dasja Pajkrt, Laura Marques, Intira J Collins, Diana M Gibb, Maria Isabel González Tome, Marisa Navarro, Josiane Warszawski, Christoph Königs, Vana Spoulou, Filipa Prata, Elena Chiappini, Lars Naver, Carlo Giaquinto, Claire Thorne, Magdalena Marczynska, Liubov Okhonskaia, Klara Posfay-Barbe, Pradthana Ounchanum, Pornchai Techakunakorn, Galina Kiseleva, Ruslan Malyuta, Alla Volokha, Luminita Ene, Ruth Goodall
BACKGROUND: Published estimates of mortality and progression to AIDS as children with HIV approach adulthood are limited. We describe rates and risk factors for death and AIDS-defining events in children and adolescents after initiation of combination antiretroviral therapy (cART) in 17 middle- and high-income countries, including some in Western and Central Europe (W&CE), Eastern Europe (Russia and Ukraine), and Thailand. METHODS AND FINDINGS: Children with perinatal HIV aged <18 years initiating cART were followed until their 21st birthday, transfer to adult care, death, loss to follow-up, or last visit up until 31 December 2013...
January 2018: PLoS Medicine
https://www.readbyqxmd.com/read/29378581/patient-and-provider-perspectives-inform-an-intervention-to-improve-linkage-to-care-for-hiv-patients-in-ukraine
#15
Tetiana Kiriazova, Oleksandr Postnov, Trista Bingham, Janet Myers, Timothy Flanigan, Charles Vitek, Oleksandr Neduzhko
BACKGROUND: Engagement with HIV medical care is critical to successful HIV treatment and prevention efforts. However, in Ukraine, delays in the timely initiation of HIV treatment hamper viral suppression. By January 01, 2016, only 126,604 (57.5%) of the estimated 220,000 people living with HIV (PLWH) had registered for HIV care, and most (55.1%) of those who registered for HIV care in 2015 did that at a late stage of infection. In the US, Anti-Retroviral Treatment and Access to Services (ARTAS) intervention successfully linked newly diagnosed PLWH to HIV services using strengths-based case management with a linkage coordinator...
January 30, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29376616/-laser-therapy-for-mens-infertility-part-2-systematic-review-of-clinical-trials
#16
O I Apolikhin, S V Moskvin
Male infertility is a multifactorial syndrome associated with a wide range of pathological conditions affecting both the sexual and other body systems: endocrine, nervous, blood, and immune. Laser therapy is a form of modern physiotherapy that applies low-intensity laser irradiation (LILI) in various parts of the body. It is widely used in all areas of modern medicine due to its high efficiency, ease of use, the absence of contraindications and side effects. The authors reviewed the results of 171 studies investigating laser therapy, of which 93 were experimental (20 in Russian and 73 international publications), four clinical and experimental (all in Russian), 74 clinical (73 in Russian and 1 in English)...
December 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/29360839/comments-on-species-divergence-in-the-genus-sphaerium-bivalvia-and-phylogenetic-affinities-of-sphaerium-nucleus-and-s-corneum-var-mamillanum-based-on-karyotypes-and-sequences-of-16s-and-its1-rdna
#17
Romualda Petkevičiūtė, Virmantas Stunžėnas, Gražina Stanevičiūtė
Chromosome, 16S and ITS1 rDNA sequence analyses were used to obtain reliable diagnostic characters and to clarify phylogenetic relationships of sphaeriid bivalves of the genus Sphaerium. The species studied were found to be diploid, with modal number 2n = 28 in S. nucleus and 2n = 30 in S. corneum var. mamillanum. Small, biarmed, C- negative B chromosomes were found in all studied populations of both species. Karyological and molecular markers revealed no differences between S. corneum s. str. and S. corneum var...
2018: PloS One
https://www.readbyqxmd.com/read/29356365/risk-network-approaches-to-locating-undiagnosed-hiv-cases-in-odessa-ukraine
#18
Pavlo Smyrnov, Leslie D Williams, Ania Korobchuk, Yana Sazonova, Georgios K Nikolopoulos, Britt Skaathun, Ethan Morgan, John Schneider, Tetyana I Vasylyeva, Samuel R Friedman
INTRODUCTION: Providing HIV healthcare and Treatment as Prevention both depend on diagnosing HIV cases, preferably soon after initial infection. We hypothesized that tracing risk networks recruits higher proportions of undiagnosed positives than outreach-based testing or respondent-driven sampling (RDS) in Odessa, Ukraine. METHODS: The Transmission Reduction Intervention Project (TRIP) used risk network tracing to recruit sexual and injection networks of recently-infected and longer-term infected (LTs) seeds (2013 to 2016)...
January 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29353928/first-reports-morphological-and-molecular-characterization-of-longidorus-caespiticola-and-longidorus-poessneckensis-nematoda-longidoridae-from-ukraine
#19
Solomia Susulovska, Pablo Castillo, Antonio Archidona-Yuste
Seven needle nematode species of the genus Longidorus have been reported in Ukraine. Nematological surveys for needle nematodes were carried out in Ukraine between 2016 and 2017 and two nematode species of Longidorus (L. caespiticola and L. poessneckensis) were collected from natural and anthropogenically altered habitats on the territory of Opillia and Zakarpattia in Ukraine. Nematodes were extracted from 500 cm3 of soil by modified sieving and decanting method. Extracted specimens were processed to glycerol and mounted on permanent slides and subsequently identified morphologically and molecularly...
December 2017: Journal of Nematology
https://www.readbyqxmd.com/read/29351780/fancm-and-recql-genetic-variants-and-breast-cancer-susceptibility-relevance-to-south-poland-and-west-ukraine
#20
Tú Nguyen-Dumont, Aleksander Myszka, Pawel Karpinski, Maria M Sasiadek, Hayane Akopyan, Fleur Hammet, Helen Tsimiklis, Daniel J Park, Bernard J Pope, Ryszard Slezak, Nataliya Kitsera, Aleksandra Siekierzynska, Melissa C Southey
BACKGROUND: FANCM and RECQL have recently been reported as breast cancer susceptibility genes and it has been suggested that they should be included on gene panel tests for breast cancer predisposition. However, the clinical value of testing for mutations in RECQL and FANCM remains to be determined. In this study, we have characterised the spectrum of FANCM and RECQL mutations in women affected with breast or ovarian cancer from South-West Poland and West Ukraine. METHODS: We applied Hi-Plex, an amplicon-based enrichment method for targeted massively parallel sequencing, to screen the coding exons and proximal intron-exon junctions of FANCM and RECQL in germline DNA from unrelated women affected with breast cancer (n = 338) and ovarian cancer (n = 89) from Poland (n = 304) and Ukraine (n = 123)...
January 19, 2018: BMC Medical Genetics
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