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https://www.readbyqxmd.com/read/28239898/early-signal-of-diverted-use-of-tropicamide-eye-drops-in-france
#1
Camille Ponté, Christian Pi, Aurore Palmaro, Emilie Jouanjus, Maryse Lapeyre-Mestre
BACKGROUND: Tropicamide is a mydriatic drug used as eye-drops for diagnostic or therapeutic purposes. From 2013, a diverted use by intravenous route has been suspected in Eastern Europe in opioids users. To recent date, no signal of a misuse has been identified in France. PURPOSE: To investigate an early signal of a diverted use of tropicamide eye drops and to collect information regarding motives of misusing and tropicamide-induced effects. METHODS: Information was obtained at 1/ regional level (Midi-Pyrénées area): reimbursement data and pharmacists' reports on suspicious requests, 2/ national level: reimbursement data and prescriptions suggesting possible abuse from the OSIAP (Ordonnances Suspectes, Indicateur d'Abus Possible) survey and 3/ international level: VigiBase® reports and Web sources...
February 27, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28230831/incidence-of-multiple-myeloma-among-cleanup-workers-of-the-chornobyl-accident-and-their-survival
#2
D Bazyka, N Gudzenko, I Dyagil, N Trotsiuk, E Gorokh, Z Fedorenko, V Chumak, E Bakhanova, I Ilienko, A Romanenko
: The study presents the updated data on the multiple myeloma (MM) incidence in Ukrainian cleanup workers after the Chornobyl accident and their survival. The epidemiological analysis is based on the extended follow-up period to identify new MM cases for higher statistical power and to collect additional data on the disease course and outcome for the survival analysis. The objective of the study was to analyze the MM incidence and survival in Chornobyl cleanup workers in 1996-2013 in comparison with the national MM statistical data...
December 2016: Experimental Oncology
https://www.readbyqxmd.com/read/28230830/several-aspects-of-descriptive-epidemiology-of-hematological-malignancies-in-adult-population-of-ukraine-belarus-and-russian-federation-after-chornobyl-accident
#3
N Guslitser, M P Zavelevich, S V Koval, D F Gluzman
Chornobyl impact on the health of adult population in Ukraine, Belarus and Russian Federation was a subject of several studies. However, the studies of the effects of Chornobyl on leukemia in adult populations in post-Soviet countries are scarce and the results are contradictory up to present. The results of the epidemiological studies of the oncohematological consequences of Chornobyl accident are briefly reviewed with particular focus on pre-Chornobyl and post-Chornobyl trends in leukemia incidence in Ukraine, Belarus and Russian Federation as well as in small territories of these countries with various levels of radionuclide contamination...
December 2016: Experimental Oncology
https://www.readbyqxmd.com/read/28230828/chromosomal-mutagenesis-in-human-somatic-cells-30-year-cytogenetic-monitoring-after-chornobyl-accident
#4
M A Pilinska, G M Shemetun, O V Shemetun, S S Dybsky, O B Dybska, O O Talan, L R Pedan, D А Kurinnyi
In the lecture we have generalized and analyzed the data of cytogenetic laboratory of National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine on 30-year selective cytogenetic monitoring among the priority contingents of different ages exposed to radiation after Chornobyl accident in Ukraine. It is highlighted that not only targeted but also untargeted radiation-induced cytogenetic effects should be explored, especially in delayed terms following radiation exposure...
December 2016: Experimental Oncology
https://www.readbyqxmd.com/read/28230824/quest-and-achievements-on-the-60-th-birth-anniversary-and-20-years-of-directorship-of-vasyl-fedorovych-chekhun
#5
(no author information available yet)
In November 2016 Director of R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology of the NAS of Ukraine, Editor-in-Chief of "Experimental Oncology" Academician of the NAS of Ukraine Vasyl Chekhun celebrated his 60(th) birth anniversary.
December 2016: Experimental Oncology
https://www.readbyqxmd.com/read/28230823/polymorphism-of-dna-repair-gene-xpd-lys751gln-and-chromosome-aberrations-in-lymphocytes-of-thyroid-cancer-patients-exposed-to-ionizing-radiation-due-to-the-chornobyl-accident
#6
V M Shkarupa, O Y Mishcheniuk, S O Henyk-Berezovska, V O Palamarchuk, S V Klymenko
: The aim of this work was to analyze the relationship between polymorphisms of DNA repair gene XPD Lys751Gln and frequency and spectrum of chromosome aberrations in the culture of peripheral blood lymphocytes of thyroid cancer (TC) patients having been exposed to ionizing radiation due to the Chornobyl accident. MATERIALS AND METHODS: XPD Lys751Gln polymorphisms were detected by polymerase chain reaction in 102 TC patients including 38 patients exposed to ionizing radiation due to Chornobyl disaster (Chornobyl recovery workers, evacuees, and the residents of contaminated areas), 64 patients without history of ionizing radiation exposure and 45 healthy residents of Ukraine as control group...
December 2016: Experimental Oncology
https://www.readbyqxmd.com/read/28230821/circulating-hematopoietic-progenitor-cells-in-patients-affected-by-chornobyl-accident
#7
N M Bilko, I S Dyagil, I Z Russu, D I Bilko
: High radiation sensitivity of stem cells and their ability to accumulate sublethal radiation damage provides the basis for investigation of hematopoietic progenitors using in vivo culture methodology. Unique samples of peripheral blood and bone marrow were derived from the patients affected by Chornobyl accident during liquidation campaign. AIM: To investigate functional activity of circulating hematopoietic progenitor cells from peripheral blood and bone marrow of cleanup workers in early and remote periods after the accident at Chornobyl nuclear power plant (CNPP)...
December 2016: Experimental Oncology
https://www.readbyqxmd.com/read/28230818/post-chornobyl-remote-radiation-effects-on-human-sperm-and-seminal-plasma-characteristics
#8
S V Andreychenko, A V Klepko, L V Gorban, O A Motryna, L V Grubska, O V Trofimenko
AIM: The research was aimed on analysis of the remote consequences of Chornobyl accident on the reproductive function of men adult residing in Ukraine. MATERIALS AND METHODS: 232 male volunteers with mean age of 34 years (range 20-47) from 5 different regions of Ukraine (Zhytomyr, Ivano-Frankivsk, Kyiv, Poltava, and Kyiv city) were enrolled in cross-sectional studies of long term radiation effects on seminal plasma and sperm. All manipulations, analysis and classification of ejaculates were done accordingly to WHO recommendations...
December 2016: Experimental Oncology
https://www.readbyqxmd.com/read/28198529/differences-of-craniotype-distribution-and-types-of-face-among-almost-healthy-men-from-different-regions-of-ukraine
#9
Igor Gunas, Mariya Shinkaruk-Dykovytska, Olga Kotsyura, Volodymir Orlovskiy, Svitlana Dmytrenko, Alla Shayuk, Olena Glushak
Established peculiarities of craniotypes distribution and types of faces in somatic healthy men, depending on regional affiliation. In all regions of Ukraine marked greater brachycephaly percentage, indicating the trend of brachycephalisation and prevalence percentage of men with narrow, very narrow face that confirms gracilization. Marked a small number of regional differences in the distribution of certain types of skull and face, indicating that the population of Ukraine is very homogeneous in anthropological composition and each of the presented Ukrainian regional types not beyond anthropological type, common to people in general...
February 15, 2017: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/28192300/efficiency-estimates-and-practical-aspects-of-an-optical-kerr-gate-for-time-resolved-luminescence-spectroscopy
#10
I Dmitruk, Ye Shynkarenko, A Dmytruk, D Aleksiuk, V Kadan, P Korenyuk, N Zubrilin, I Blonskiy
We report experience of assembling an optical Kerr gate setup at the Femtosecond Laser Center for collective use at the Institute of Physics of the National Academy of Sciences of Ukraine. This offers an inexpensive solution to the problem of time-resolved luminescence spectroscopy. Practical aspects of its design and alignment are discussed and its main characteristics are evaluated. Theoretical analysis and numerical estimates are performed to evaluate the efficiency and the response time of an optical Kerr gate setup for fluorescence spectroscopy with subpicosecond time resolution...
October 11, 2016: Methods and Applications in Fluorescence
https://www.readbyqxmd.com/read/28184181/reassessment-of-allantonectria-phylogenetic-position-of-thyronectroidea-and-thyronectria-caraganae-sp-nov
#11
Hermann Voglmayr, Olexander Yu Akulov, Walter M Jaklitsch
The genus Allantonectria is synonymised with Thyronectria, based on morphological and molecular phylogenetic considerations. Investigations of types and fresh collections revealed that Tubercularia concentrica is an earlier name for Sphaeria (syn. Allantonectria) miltina and is thus combined in Thyronectria. Allantonectria yuccae is recognised as a distinct species and transferred to Thyronectria, as well as the recently described A. zangii. Descriptions and illustrations are provided for T. concentrica and T...
September 2016: Mycological Progress
https://www.readbyqxmd.com/read/28173763/risk-factors-for-poor-multidrug-resistant-tuberculosis-treatment-outcomes-in-kyiv-oblast-ukraine
#12
Omowunmi Aibana, Mariya Bachmaha, Viatcheslav Krasiuk, Natasha Rybak, Timothy P Flanigan, Vasyl Petrenko, Megan B Murray
BACKGROUND: Ukraine is among ten countries with the highest burden of multidrug- resistant TB (MDR-TB) worldwide. Treatment success rates for MDR-TB in Ukraine remain below global success rates as reported by the World Health Organization. Few studies have evaluated predictors of poor MDR-TB outcomes in Ukraine. METHODS: We conducted a retrospective analysis of patients initiated on MDR-TB treatment in the Kyiv Oblast of Ukraine between January 01, 2012 and March 31st, 2015...
February 7, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28169608/vitamin-d-deficiency-in-pregnant-ukrainian-women-effects-of-alcohol-consumption-on-vitamin-d-status
#13
Charles R Carlson, Janet Y Uriu-Adams, Christina D Chambers, Lyubov Yevtushok, Natalya Zymak-Zakutnya, Priscilla H Chan, Jordan J Schafer, Wladimir Wertelecki, Carl L Keen
OBJECTIVE: Heavy alcohol consumption can alter vitamin D status; however, the relationships between alcohol consumption and vitamin D concentrations in pregnant women have not been well studied. The aim of this study was to investigate the vitamin D status in a population of alcohol-exposed (N = 180) and low/unexposed control (N = 179) Ukrainian pregnant women. METHODS: Women who attended prenatal care facilities in 2 regions of Ukraine (Rivne and Khmelnytsky) for a routine prenatal visit were screened for the study...
January 2017: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/28162894/the-neolithic-transition-in-the-baltic-was-not-driven-by-admixture-with-early-european-farmers
#14
Eppie R Jones, Gunita Zarina, Vyacheslav Moiseyev, Emma Lightfoot, Philip R Nigst, Andrea Manica, Ron Pinhasi, Daniel G Bradley
The Neolithic transition was a dynamic time in European prehistory of cultural, social, and technological change. Although this period has been well explored in central Europe using ancient nuclear DNA [1, 2], its genetic impact on northern and eastern parts of this continent has not been as extensively studied. To broaden our understanding of the Neolithic transition across Europe, we analyzed eight ancient genomes: six samples (four to ∼1- to 4-fold coverage) from a 3,500 year temporal transect (∼8,300-4,800 calibrated years before present) through the Baltic region dating from the Mesolithic to the Late Neolithic and two samples spanning the Mesolithic-Neolithic boundary from the Dnieper Rapids region of Ukraine...
February 20, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28160736/patterns-of-harm-reduction-service-utilization-and-hiv-incidence-among-people-who-inject-drugs-in-ukraine-a-two-part-latent-profile-analysis
#15
Danielle C Ompad, Jiayu Wang, Konstantin Dumchev, Julia Barska, Maria Samko, Oleksandr Zeziulin, Tetiana Saliuk, Olga Varetska, Jack DeHovitz
BACKGROUND: Program utilization patterns are described within a large network of harm reduction service providers in Ukraine. The relationship between utilization patterns and HIV incidence is determined among people who inject drugs (PWID) controlling for oblast-level HIV incidence and treatment/syringe coverage. METHODS: Data were extracted from the network's monitoring and evaluation database (January 2011-September 2014, n=327,758 clients). Latent profile analysis was used to determine harm reduction utilization patterns using the number of HIV tests received annually and the number of condoms, syringes, and services (i...
February 1, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28149137/clinico-epidemiological-analysis-of-hiv-aids-patients
#16
Baris Ertunc, Selcuk Kaya, Iftihar Koksal
OBJECTIVE: The aim of this study was to examine clinico-epidemiological properties of HIV/AIDS patients. MATERIALS AND METHODS: For this purpose, 115 HIV/AIDS patients monitored in our clinic between January 1, 1998, and December 31, 2013, were retrospectively evaluated. RESULTS: For the 115 patients with a diagnosis of HIV/AIDS that we monitored, the mean age at the time of presentation was 34.5±13.21 (10-79) years. Eighty-nine (76.5%) patients were male and 27 (23...
October 2016: Eurasian Journal of Medicine
https://www.readbyqxmd.com/read/28139462/fluorescence-research-in-ukraine
#17
Leonid D Patsenker
No abstract text is available yet for this article.
January 30, 2017: Methods and Applications in Fluorescence
https://www.readbyqxmd.com/read/28129985/safety-and-efficacy-of-pitolisant-on-cataplexy-in-patients-with-narcolepsy-a-randomised-double-blind-placebo-controlled-trial
#18
Zoltan Szakacs, Yves Dauvilliers, Vladimir Mikhaylov, Irina Poverennova, Sergei Krylov, Slavko Jankovic, Karel Sonka, Philippe Lehert, Isabelle Lecomte, Jeanne-Marie Lecomte, Jean-Charles Schwartz
BACKGROUND: Histaminergic neurons are crucial to maintain wakefulness, but their role in cataplexy is unknown. We assessed the safety and efficacy of pitolisant, a histamine H3 receptor inverse agonist, for treatment of cataplexy in patients with narcolepsy. METHODS: For this randomised, double-blind, placebo-controlled trial we recruited patients with narcolepsy from 16 sleep centres in nine countries (Bulgaria, Czech Republic, Hungary, Macedonia, Poland, Russia, Serbia, Turkey, and Ukraine)...
24, 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28127993/three-persons-three-genetic-contributors-three-parents-mitochondrial-donation-genetic-parenting-and-the-immutable-grammar-of-the-three-x-x
#19
Rebecca Dimond, Neil Stephens
In 2015, two novel in vitro fertilisation techniques intended to prevent the inheritance of mitochondrial disease were legalised in the United Kingdom, following an intense period of inquiry including scientific reviews, public consultations, government guidance and debates within the Houses of Parliament. The techniques were controversial because (1) they introduced a third genetic contributor into the reproductive process and (2) they are germline, meaning this genetic change could then be passed down to subsequent generations...
January 1, 2017: Health (London)
https://www.readbyqxmd.com/read/28124602/crimean-congo-hemorrhagic-fever-virus-in-pakistan
#20
Iftikhar Ali, Afaq Rahim, Muhammad Ijaz
The Crimean-Congo hemorrhagic fever is a zoonotic disease transmitted by ticks and is characterized by fever and bleeding. It was seen for the first time in the south of present day Ukraine and thus named, Crimean fever. 1 In 1956, the virus was isolated in a patient with similar symptoms residing in Congo, Kenya and the virus was named Congo virus. The viruses causing these two diseases were the same and hence was termed Crimean-Congo hemorrhagic fever virus (CCHFV). Humans are the only known host that develops disease...
January 17, 2017: Infectious Disorders Drug Targets
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