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https://www.readbyqxmd.com/read/28815856/molecular-dynamics-insights-into-polyamine-dna-binding-modes-implications-for-cross-link-selectivity
#1
Emmanuelle Bignon, Chen-Hui Chan, Christophe Morell, Antonio Monari, Jean-Luc Ravanat, Elise Dumont
Biogenic polyamines, which play a role in DNA condensation and stabilization, are ubiquitous and are found at millimolar concentration in the nucleus of eukaryotic cells. The interaction modes of three polyamines-putrescine (Put), spermine (Spm), and spermidine (Spd)-with a self-complementary 16 base pair (bp) duplex, are investigated by all-atom explicit-solvent molecular dynamics. The length of the amine aliphatic chain leads to a change of the interaction mode from minor groove binding to major groove binding...
August 16, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28815369/suspended-particulate-matter-collection-methods-influence-the-quantification-of-polycyclic-aromatic-compounds-in-the-river-system
#2
Fayez Abuhelou, Laurence Mansuy-Huault, Catherine Lorgeoux, Delphine Catteloin, Valéry Collin, Allan Bauer, Hussein Jaafar Kanbar, Renaud Gley, Luc Manceau, Fabien Thomas, Emmanuelle Montargès-Pelletier
In this study, we compared the influence of two different collection methods, filtration (FT) and continuous flow field centrifugation (CFC), on the concentration and the distribution of polycyclic aromatic compounds (PACs) in suspended particulate matter (SPM) occurring in river waters. SPM samples were collected simultaneously with FT and CFC from a river during six sampling campaigns over 2 years, covering different hydrological contexts. SPM samples were analyzed to determine the concentration of PACs including 16 polycyclic aromatic hydrocarbons (PAHs), 11 oxygenated PACs (O-PACs), and 5 nitrogen PACs (N-PACs)...
August 16, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28806690/occurrence-and-distribution-of-halogenated-flame-retardants-in-an-urban-watershed-comparison-to-polychlorinated-biphenyls-and-organochlorine-pesticides
#3
Qian Wang, Barry C Kelly
Due to restrictions on polybrominated diphenyl ethers (PBDEs), market demand for alternative flame retardants is projected to increase, worldwide. Information regarding the environmental behavior of these compounds is limited. The present study involved field measurements of several alternative halogenated flame retardants (HFRs), along with PBDEs and legacy persistent organic pollutants (POPs) in surface water, bottom sediments and suspended particulate matter (SPM) within a highly urbanized watershed in Singapore...
August 11, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28803188/remediation-of-internal-phosphorus-loads-with-modified-clays-influence-of-fluvial-suspended-particulate-matter-and-response-of-the-benthic-macroinvertebrate-community
#4
Hongbin Yin, Grant B Douglas, Yongjiu Cai, Cheng Liu, Diego Copetti
Clay-based phosphorus (P) sorbents have been increasingly used as geoengineering materials for the management sediment-derived internal P loading in eutrophic lakes. However, the long-term behavior of these sorbents has remained elusive along with their response to burial under suspended particulate matter (SPM), and their effect on macroinvertebrate communities occupying dynamic regions at the sediment-water interface of shallow and turbid lakes. In this study, field mesocosm experiments were undertaken in Lake Chaohu, China, to study the effects of the application of lanthanum-modified bentonite (LMB) and thermally-modified calcium-rich attapulgite (TCAP) on sediment internal P loading and to assess their influence on macroinvertebrate community structure...
August 10, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28802833/new-pro-resolving-n-3-mediators-bridge-resolution-of-infectious-inflammation-to-tissue-regeneration
#5
REVIEW
Charles N Serhan, Nan Chiang, Jesmond Dalli
While protective, the acute inflammatory response when uncontrolled can lead to further tissue damage and chronic inflammation that is now widely recognized to play important roles in many commonly occurring diseases, such as cardiovascular disease, neurodegenerative diseases, metabolic syndrome, and many other diseases of significant public health concern. The ideal response to initial challenges of the host is complete resolution of the acute inflammatory response, which is now recognized to be a biosynthetically active process governed by specialized pro-resolving mediators (SPM)...
August 9, 2017: Molecular Aspects of Medicine
https://www.readbyqxmd.com/read/28799271/reduced-disease-specific-survival-following-a-diagnosis-of-multiple-primary-cutaneous-malignant-melanomas-a-nationwide-population-based-study
#6
Deborah Utjés, Johan Lyth, Jan Lapins, Hanna Eriksson
Outcome data comparing patients with multiple primary invasive cutaneous malignant melanomas (MPMs) to single primary invasive cutaneous malignant melanoma (SPM) show conflicting results. We have analyzed differences in disease-specific survival between these patients in a nationwide population-based setting. From the Swedish Melanoma Register, 27,235 patients were identified with a first invasive cutaneous malignant melanoma (CMM) between 1990 and 2007, followed-up through 2013. Of these, 700 patients developed MPMs...
August 11, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28797948/a-scanning-probe-mounted-on-a-field-effect-transistor-characterization-of-ion-damage-in-si
#7
Kumjae Shin, Hoontaek Lee, Min Sung, Sang Hoon Lee, Hyunjung Shin, Wonkyu Moon
We have examined the capabilities of a Tip-On-Gate of Field-Effect Transistor (ToGoFET) probe for characterization of FIB-induced damage in Si surface. A ToGoFET probe is the SPM probe which the Field Effect Transistor(FET) is embedded at the end of a cantilever and a Pt tip was mounted at the gate of FET. The ToGoFET probe can detect the surface electrical properties by measuring source-drain current directly modulated by the charge on the tip. In this study, a Si specimen whose surface was processed with Ga+ ion beam was prepared...
July 24, 2017: Micron: the International Research and Review Journal for Microscopy
https://www.readbyqxmd.com/read/28794970/agreement-of-msmetrix-with-established-methods-for-measuring-cross-sectional-and-longitudinal-brain-atrophy
#8
Martijn D Steenwijk, Houshang Amiri, Menno M Schoonheim, Alexandra de Sitter, Frederik Barkhof, Petra J W Pouwels, Hugo Vrenken
INTRODUCTION: Despite the recognized importance of atrophy in multiple sclerosis (MS), methods for its quantification have been mostly restricted to the research domain. Recently, a CE labelled and FDA approved MS-specific atrophy quantification method, MSmetrix, has become commercially available. Here we perform a validation of MSmetrix against established methods in simulated and in vivo MRI data. METHODS: Whole-brain and gray matter (GM) volume were measured with the cross-sectional pipeline of MSmetrix and compared to the outcomes of FreeSurfer (cross-sectional pipeline), SIENAX and SPM...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28782314/association-of-environmental-factors-prevalence-of-asthma-and-respiratory-morbidity-in-mumbai-need-of-a-public-health-policy
#9
Amita Athavale, Hariharan Iyer, Aditi D Punwani, Jeenam J Shah, Gita Natraj, Jairaj P Nair, Rakesh Kumar, Lakshmi R Menon, Aparna N Iyer, Sagar J Raiya
OBJECTIVE: To study the association between environmental factors, prevalence of asthma and respiratory morbidity in relation to air quality levels in a mega city. To study modifiable environmental factors in people with diagnosed asthma and increased respiratory morbidity. METHODS: Cross sectional survey of population (N-3233) from 6 localities near air quality stations was done to study prevalence of asthma and respiratory morbidity (n-1006) followed by case control study of environmental factors by air sampling to study biological contamination...
June 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28776053/effect-of-spermine-derived-ages-on-oxidative-stress-and-polyamine-metabolism
#10
Ayumi Tsutsui, Ambara R Pradipta, Shinobu Kitazume, Naoyuki Taniguchi, Katsunori Tanaka
Non-enzymatic glycation between proteins and carbohydrates, such as advanced glycation end products (AGEs), are naturally occurring compounds implicated in aging and numerous degenerative diseases. Methyl glyoxal (MG), which is an intermediate of the AGE biosynthetic pathway, is known to react with primary amines of proteins to create a wide range of AGE modifications, such as carboxyethyl lysine (CEL) and methylglyoxal-derived lysine dimer (MOLD). As a means to investigate and probe the ROS production pathways of AGEs, low molecular weight compounds carboxyethyl spermine (CES) and methylglyoxal-derived spermine dimer (MOSD) were synthesized, which replace lysine with another highly nucleophilic biological amine, spermine (SPM)...
August 16, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28774552/nitrogen-exchange-across-the-sediment-water-interface-after-dredging-the-influence-of-contaminated-riverine-suspended-particulate-matter
#11
Cheng Liu, Kaining Chen, Zhaode Wang, Chengxin Fan, Xiaozhi Gu, Wei Huang
Dredging has been widely implemented in shallow lakes to reduce internal nitrogen (N) loading. The suspended particulate matter (SPM) coming from polluted rivers usually contains high levels of N and ultimately deposits on the dredged sediment surfaces near the river mouth. To study the influence of the riverine SPM on N exchange across the sediment-water interface (SWI) after dredging, a 360-day experiment was carried out comparing un-dredged and dredged sediments from Lake Chaohu, China. Dredged treatments showed a significant increase (p < 0...
August 1, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28767146/a-randomised-trial-of-effects-of-alcohol-on-cytochrome-p450-eicosanoids-mediators-of-inflammation-resolution-and-blood-pressure-in-men
#12
Anne E Barden, Venus Chavez, Michael Phillips, Emilie Mas, Lawrence J Beilin, Kevin D Croft, Trevor A Mori, Ian B Puddey
BACKGROUND: Cardiovascular effects of alcohol consumption may be influenced by both pro- and anti-inflammatory mechanisms. We previously showed that chronic alcohol consumption increased blood pressure (BP), oxidative stress and 20-hydroxyeicosatetraenoic acid (20-HETE), a vasoconstrictor and pro-inflammatory eicosanoid synthesised by CYP450 enzymes from arachidonic acid. This study in men examined the effect of consuming red wine (RW) on BP in relation to changes in 20-HETE, oxidative stress (F2 -isoprostanes), markers of inflammation, anti-inflammatory CYP450 epoxyeicosatrienoic acids (EETs) and specialised pro-resolving mediators of inflammation (SPMs) derived from eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)...
August 2, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28766334/facilitating-proton-transport-in-nafion-based-membranes-at-low-humidity-by-incorporating-multifunctional-graphene-oxide-nanosheets
#13
Xueyi He, Guangwei He, Anqi Zhao, Fei Wang, Xunli Mao, Yongheng Yin, Li Cao, Bei Zhang, Hong Wu, Zhongyi Jiang
Nafion, as a state-of-the-art solid electrolyte for proton exchange membrane fuel cells (PEMFCs), suffers from drastic decline in proton conductivity with decreasing humidity, which significantly restricts the efficient and stable operation of the fuel cell system. In this study, the proton conductivity of Nafion at low relative humidity (RH) was remarkably enhanced by incorporating multifunctional graphene oxide (GO) nanosheets as multifunctional fillers. Through surface-initiated atom transfer radical polymerization of sulfopropyl methacrylate (SPM) and poly(ethylene glycol) methyl ether methacrylate, the copolymer-grafted GO was synthesized and incorporated into the Nafion matrix, generating efficient paths at the Nafion-GO interface for proton conduction...
August 10, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28765512/a-cluster-of-immunoresolvents-links-coagulation-to-innate-host-defense-in-human-blood
#14
Paul C Norris, Stephania Libreros, Nan Chiang, Charles N Serhan
Blood coagulation is a protective response that prevents excessive bleeding upon blood vessel injury. We investigated the relationship between coagulation and the resolution of inflammation and infection by lipid mediators (LMs) through metabololipidomics-based profiling of human whole blood (WB) during coagulation. We identified temporal clusters of endogenously produced prothrombotic and proinflammatory LMs (eicosanoids), as well as specialized proresolving mediators (SPMs). In addition to eicosanoids, a specific SPM cluster was identified that consisted of resolvin E1 (RvE1), RvD1, RvD5, lipoxin B4, and maresin 1, each of which was present at bioactive concentrations (0...
August 1, 2017: Science Signaling
https://www.readbyqxmd.com/read/28765077/resolution-of-vascular-injury-specialized-lipid-mediators-and-their-evolving-therapeutic-implications
#15
REVIEW
Bian Wu, Giorgio Mottola, Melinda Schaller, Gilbert R Upchurch, Michael S Conte
Acute vascular injury occurs in a number of important clinical contexts, including spontaneous disease-related events (e.g. plaque rupture, thrombosis) and therapeutic interventions such as angioplasty, stenting, or bypass surgery. Endothelial cell (EC) disruption exposes the underlying matrix, leading to a rapid deposition of platelets, coagulation proteins, and leukocytes. A thrombo-inflammatory response ensues characterized by leukocyte recruitment, vascular smooth muscle cell (VSMC) activation, and the elaboration of cytokines, reactive oxygen species and growth factors within the vessel wall...
August 3, 2017: Molecular Aspects of Medicine
https://www.readbyqxmd.com/read/28765056/predicting-brain-age-with-deep-learning-from-raw-imaging-data-results-in-a-reliable-and-heritable-biomarker
#16
James H Cole, Rudra P K Poudel, Dimosthenis Tsagkrasoulis, Matthan W A Caan, Claire Steves, Tim D Spector, Giovanni Montana
Machine learning analysis of neuroimaging data can accurately predict chronological age in healthy people. Deviations from healthy brain ageing have been associated with cognitive impairment and disease. Here we sought to further establish the credentials of 'brain-predicted age' as a biomarker of individual differences in the brain ageing process, using a predictive modelling approach based on deep learning, and specifically convolutional neural networks (CNN), and applied to both pre-processed and raw T1-weighted MRI data...
July 29, 2017: NeuroImage
https://www.readbyqxmd.com/read/28762536/a-novel-mr-based-method-for-detection-of-cartilage-delamination-in-femoroacetabular-impingement-patients
#17
Michael A Samaan, Valentina Pedoia, Alan L Zhang, Matthew C Gallo, Thomas M Link, Richard B Souza, Sharmila Majumdar
In this study, quantitative magnetic resonance based measurements were used to evaluate T1ρ and T2 mapping and heterogeneity in femoroacetabular impingement (FAI) patients with acetabular cartilage delamination and to determine the ability of these quantitative MR-based measurements in detecting delamination. Unilateral hip joint MR-scans of 36 FAI patients with arthroscopically-confirmed acetabular cartilage delamination and 36 age, gender and BMI matched controls were obtained. T1ρ and T2 mapping and heterogeneity of the hip joint articular cartilage were assessed in both groups using voxel-based relaxometry (VBR)...
August 1, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28761571/extending-inferential-group-analysis-in-type-2-diabetic-patients-with-multivariate-glm-implemented-in-spm8
#18
Fábio S Ferreira, João M S Pereira, João V Duarte, Miguel Castelo-Branco
BACKGROUND: Although voxel based morphometry studies are still the standard for analyzing brain structure, their dependence on massive univariate inferential methods is a limiting factor. A better understanding of brain pathologies can be achieved by applying inferential multivariate methods, which allow the study of multiple dependent variables, e.g. different imaging modalities of the same subject. OBJECTIVE: Given the widespread use of SPM software in the brain imaging community, the main aim of this work is the implementation of massive multivariate inferential analysis as a toolbox in this software package...
2017: Open Neuroimaging Journal
https://www.readbyqxmd.com/read/28761118/bortezomib-before-and-after-high-dose-therapy-in-myeloma-long-term-results-from-the-phase-iii-hovon-65-gmmg-hd4-trial
#19
H Goldschmidt, H M Lokhorst, E K Mai, B van der Holt, I W Blau, S Zweegman, K C Weisel, E Vellenga, M Pfreundschuh, M J Kersten, C Scheid, S Croockewit, R Raymakers, D Hose, A Potamianou, A Jauch, J Hillengass, M Stevens-Kroef, M S Raab, A Broijl, H W Lindemann, G M J Bos, P Brossart, M van Marwijk Kooy, P Ypma, U Duehrsen, R M Schaafsma, U Bertsch, T Hielscher, Le Jarari, H J Salwender, P Sonneveld
The Dutch-Belgian Cooperative Trial Group for Hematology Oncology Group-65/German-speaking Myeloma Multicenter Group-HD4 (HOVON-65/GMMG-HD4) phase III trial compared bortezomib (BTZ) before and after high-dose melphalan and autologous stem cell transplantation (HDM, PAD arm) compared with classical cytotoxic agents prior and thalidomide after HDM (VAD arm) in multiple myeloma (MM) patients aged 18-65 years. Here, the long-term follow-up and data on second primary malignancies (SPM) are presented. After a median follow-up of 96 months, progression-free survival (censored at allogeneic transplantation, PFS) remained significantly prolonged in the PAD versus VAD arm (hazard ratio (HR)=0...
July 4, 2017: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/28750492/parkinson-disease-related-cortical-and-striatal-cognitive-patterns-in-dual-time-f-18-fp-cit-evidence-for-neural-correlates-between-the-caudate-and-the-frontal-lobe
#20
Hye J Son, Young J Jeong, Hyun J Yoon, Jae W Kim, Go-E Choi, Jong H Park, Do-Y Kang
BACKGROUND: Using dual time F-18 FP-CIT, we evaluated cortical perfusion, striatal binding and neuropsychological performance simultaneously in Parkinson's disease (PD) with and without mild cognitive impairment (MCI), to investigate neural correlates between caudate and frontal cortex. METHODS: According to the neuropsychological scores, subjects were classified into 26 healthy controls (HC), 38 PD-MCI (executive) (PE), 24 PD-MCI (non-executive) (PN) and 21 PD (motor) (PM)...
July 27, 2017: Quarterly Journal of Nuclear Medicine and Molecular Imaging
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