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https://www.readbyqxmd.com/read/29328276/femto-nano-second-switchable-passively-mode-locked-fiber-laser-with-analytic-modeling-by-the-cubic-quintic-ginzburg-landau-equation
#1
Wen-Hsuan Kuan, Li-Ting Kao, Jing-Yun Wang, Kuei-Huei Lin
We report a passively mode-locked erbium-doped fiber laser with pulse widths switchable from 473 fs to 76.8 ns, where the fundamental mode-locking, noise-like pulse, nanosecond mode-locking, and dual-width mode-locking (DML) are obtained by adjusting a polarization controller. Co-existence of femto- and nano-second pulses in DML is attributed to the gain balancing. Analytic modeling of the fiber laser with the cubic-quintic Ginzburg-Landau equation is presented, in which the pulse widths are calculated as functions of dispersion, self-phase modulation (SPM), cubic saturable absorption (SA), and quintic SA...
January 15, 2018: Optics Letters
https://www.readbyqxmd.com/read/29325327/-resting-state-network-evaluation-of-chronic-smokers-by-functional-magnetic-resonance-imaging
#2
Y Zhang, Y L Li, J L Cheng, A K Dong, K Xu, Y L Li
Objective: To explore the neuromechanism of nicotine smoking, we use independent component analysis (ICA) of resting-state functional magnetic resonance imaging (fMRI) to investigate the differences of functional connectivity of resting-state networks (RSN) in chronic smokers. Methods: Forty-five chronic smokers and thirty-four age and gender matched normal nonsmoking controls experienced resting-state fMRI scanning in 3.0T MRI scanner.Differences of the function connection in each RSN between chronic smokers group and nonsmoking controls group were analyzed by SPM software which was based on Matlab platform...
December 19, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29306814/spatiotemporal-distribution-and-potential-risk-assessment-of-microcystins-in-the-yulin-river-a-tributary-of-the-three-gorges-reservoir-china
#3
Qiang He, Li Kang, Xingfu Sun, Ruxue Jia, Ying Zhang, Jiangsen Ma, Hong Li, Hainan Ai
Microcystins (MCs) pose potential threat for both aquatic organisms and humans, whereas their occurrence in response to hydrodynamic alterations are not clearly understood. Here, spatiotemporal variations of dissolved MC-RR and MC-LR were evaluated monthly in 2016 in the Yulin River, a tributary of the Three Gorges Reservoir (TGR). The environmental factors that linked to MCs concentration were discussed. The results revealed that MC-RR maximumly reached 3.55 μg/L, and the maximum MC-LR concentration exceeded the threshold value of 1...
January 3, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29305547/evaluation-of-the-amplidiag-carbar-vre-kit-for-the-accurate-detection-of-carbapenemase-producing-bacteria
#4
Saoussen Oueslati, Delphine Girlich, Laurent Dortet, Thierry Naas
As carbapenemase-producing Gram-negative bacilli (CP-GNB) (Enterobacteriaceae, Pseudomonadaceae and Acinetobacter spp.) are becoming a major public health issue, there is an urgent need for accurate and fast diagnostic tests. Amplidiag® Carba-R+VRE assay is a multiplex nucleic acid-based in-vitro diagnostic test intended for the detection of CP-GNB and vancomycin resistant enterococci (VRE) from cultured colonies.We have evaluated its ability to detect carbapenemases genes in 100 well-characterized GNB, and in 200 consecutive enterobacterial isolates with reduced susceptibility to carbapenems and that were referred to the French National Reference Center for carbapenem-resistance...
January 5, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29302056/human-macrophages-differentially-produce-specific-resolvin-or-leukotriene-signals-that-depend-on-bacterial-pathogenicity
#5
Oliver Werz, Jana Gerstmeier, Stephania Libreros, Xavier De la Rosa, Markus Werner, Paul C Norris, Nan Chiang, Charles N Serhan
Proinflammatory eicosanoids (prostaglandins and leukotrienes) and specialized pro-resolving mediators (SPM) are temporally regulated during infections. Here we show that human macrophage phenotypes biosynthesize unique lipid mediator signatures when exposed to pathogenic bacteria. E. coli and S. aureus each stimulate predominantly proinflammatory 5-lipoxygenase (LOX) and cyclooxygenase pathways (i.e., leukotriene B4 and prostaglandin E2) in M1 macrophages. These pathogens stimulate M2 macrophages to produce SPMs including resolvin D2 (RvD2), RvD5, and maresin-1...
January 4, 2018: Nature Communications
https://www.readbyqxmd.com/read/29299658/fast-and-feasible-ultrasound-assisted-pretreatment-for-the-determination-of-organotin-compounds-in-environmental-samples
#6
Pamela Y Quintas, Ana L Oliva, Mónica B Alvarez, Andres H Arias, Claudia E Domini, Mariano Garrido, Jorge E Marcovecchio
The goal of this study was to improve an already established reference method, such as the one devoted to organotin compounds determination (Reference Method for Marine Pollution Studies, No. 59, UNEP). The proposed upgrade consists of replacing the mechanical shaking by ultrasound energy and applying low temperature throughout the whole procedure. The optimization of the new operational conditions was performed by using a factorial design. Quality control was performed using a certified sediment reference material (PACS-2) for sediments (82...
January 3, 2018: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/29289234/digitally-controlled-analog-proportional-integral-derivative-pid-controller-for-high-speed-scanning-probe-microscopy
#7
Maja Dukic, Vencislav Todorov, Santiago Andany, Adrian P Nievergelt, Chen Yang, Nahid Hosseini, Georg E Fantner
Nearly all scanning probe microscopes (SPMs) contain a feedback controller, which is used to move the scanner in the direction of the z-axis in order to maintain a constant setpoint based on the tip-sample interaction. The most frequently used feedback controller in SPMs is the proportional-integral (PI) controller. The bandwidth of the PI controller presents one of the speed limiting factors in high-speed SPMs, where higher bandwidths enable faster scanning speeds and higher imaging resolution. Most SPM systems use digital signal processor-based PI feedback controllers, which require analog-to-digital and digital-to-analog converters...
December 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/29280719/relationship-between-sensory-processing-and-pretend-play-in-typically-developing-children
#8
Tara Roberts, Karen Stagnitti, Ted Brown, Anoo Bhopti
OBJECTIVE: We sought to investigate the relationship between sensory processing and pretend play in typically developing children. METHOD: Forty-two typically developing children ages 5-7 yr were assessed with the Child Initiated Pretend Play Assessment and the Home and Main Classroom forms of the Sensory Processing Measure (SPM). RESULTS: There were significant relationships between elaborate pretend play and body awareness (r = .62, p < ...
January 2018: American Journal of Occupational Therapy: Official Publication of the American Occupational Therapy Association
https://www.readbyqxmd.com/read/29280715/comparison-of-two-tools-to-assess-sensory-features-in-children-with-autism-spectrum-disorder
#9
Catherine Dugas, Marie-Noëlle Simard, Eric Fombonne, Mélanie Couture
OBJECTIVE: This article documents the convergent validity of the Sensory Profile (SP) and the Sensory Processing Measure (SPM)-Home Form for children with autism spectrum disorder (ASD). METHO: . Parents of 34 children with ASD between ages 5 and 8 yr filled out both measures. Through correlations, χ² tests, and levels of agreement between classifications, the results for the SP and the SPM-Home Form were compared. RESULTS: The raw scores were correlated for some sensory domains (hearing, vision, touch, and proprioception) and for social functioning...
January 2018: American Journal of Occupational Therapy: Official Publication of the American Occupational Therapy Association
https://www.readbyqxmd.com/read/29275315/clinical-and-prognostic-analysis-of-hypopharyngeal-squamous-cell-carcinoma-with-synchronous-and-metachronous-multiple-malignancies
#10
Keisuke Yamamoto, Kenichi Takano, Atsushi Kondo, Makoto Kurose, Kazufumi Obata, Tetsuo Himi
BACKGROUND/AIM: To analyze the clinical features and prevalence of synchronous and metachronous second primary malignancies (SPMs) in patients with hypopharyngeal squamous cell carcinoma (HSCC), their associated risk factors, and cause-specific mortality. PATIENTS AND METHODS: We retrospectively reviewed 136 patients treated with curative intent at our hospital. Statistical analyses were performed to determine factors predictive of SPM and cause-specific mortality...
January 2018: In Vivo
https://www.readbyqxmd.com/read/29275256/sources-and-distribution-of-aromatic-hydrocarbons-in-a-tropical-marine-protected-area-estuary-under-influence-of-sugarcane-cultivation
#11
Roxanny Helen de Arruda-Santos, Carlos Augusto França Schettini, Gilvan Takeshi Yogui, Daniele Claudino Maciel, Eliete Zanardi-Lamardo
Goiana estuary is a well preserved marine protected area (MPA) located on the northeastern coast of Brazil. Despite its current state, human activities in the watershed represent a potential threat to long term local preservation. Dissolved/dispersed aromatic hydrocarbons and polycyclic aromatic hydrocarbons (PAHs) were investigated in water and sediments across the estuarine salt gradient. Concentration of aromatic hydrocarbons was low in all samples. According to results, aromatic hydrocarbons are associated to suspended particulate matter (SPM) carried to the estuary by river waters...
December 21, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29274110/metabolic-correlates-of-cognitive-function-in-children-with-unilateral-sturge-weber-syndrome-evidence-for-regional-functional-reorganization-and-crowding
#12
Jeong-A Kim, Jeong-Won Jeong, Michael E Behen, Vinod K Pilli, Aimee Luat, Harry T Chugani, Csaba Juhász
To evaluate metabolic changes in the ipsi- and contralateral hemisphere in children showing a cognitive profile consistent with early reorganization of cognitive function, we evaluated the regional glucose uptake, interhemispheric metabolic connectivity, and cognitive function in children with unilateral SWS. Interictal 2-deoxy-2[18 F]fluoro-D-glucose (FDG)-PET scans of 27 children with unilateral SWS and mild epilepsy and 27 age-matched control (non-SWS children with epilepsy and normal FDG-PET) were compared using statistical parametric mapping (SPM)...
December 23, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/29250863/cyclobutanone-mimics-of-intermediates-in-metallo-%C3%AE-lactamase-catalysis
#13
Martine I Abboud, Magda Kosmopoulou, Anthony Krismanich, Jarrod W Johnson, Philip Hinchliffe, Jürgen Brem, Timothy D W Claridge, James Spencer, Christopher Schofield, Gary I Dmitrienko
The most important resistance mechanism to β-lactam antibiotics involves hydrolysis by two β-lactamase categories: the nucleophilic serine (SBL) and the metallo- (MBL) β-lactamases. Cyclobutanones are hydrolytically stable β-lactam analogues with potential to inhibit both SBLs and MBLs. We describe solution and crystallographic studies on the interaction of a cyclobutanone penem analogue with the clinically important MBL SPM-1. NMR experiments using 19F-labeled SPM-1 imply the cyclobutanone binds to SPM-1 with micromolar affinity...
December 17, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29249019/acrolein-toxicity-at-advanced-age-present-and-future
#14
REVIEW
Kazuei Igarashi, Takeshi Uemura, Keiko Kashiwagi
It is thought that tissue damage at advanced age is mainly caused by ROS (reactive oxygen species, O2-, H2O2, and ·OH). However, it was found that acrolein (CH2=CH-CHO) is more toxic than ROS, and is mainly produced from spermine (SPM), one of the polyamines, rather than from unsaturated fatty acids. Significant amounts of SPM are present normally as SPM-ribosome complexes, and contribute to protein synthesis. However, SPM was released from ribosomes due to the degradation of ribosomal RNA by ·OH or the binding of Ca2+ to ribosomes, and acrolein was produced from free SPM by polyamine oxidases, particularly by SPM oxidase...
December 16, 2017: Amino Acids
https://www.readbyqxmd.com/read/29239473/polyamines-regulating-phytic-acid-degradation-in-mung-bean-sprouts
#15
Ting Zhou, Pei Wang, Runqiang Yang, Zhenxin Gu
BACKGROUND: Polyamines are essentially involved in cell division and differentiation. Transport of polyamine is ATP dependent, while phytic acid is the major reserve of phosphate essential to the energy-producing machinery of cells. Thus, polyamines might enhance phytic acid degradation during mung bean germination. In this study, different polyamines [putrescine (Put), spermidine (Spd) and spermine (Spm)] and dicyclohexylamine (DCHA, a Spd synthesis inhibitor) were applied to investigate the function of polyamines on phytic acid degradation...
December 14, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29224710/spm-1-producing-pseudomonas-aeruginosa-st277-clone-recovered-from-microbiota-of-migratory-birds
#16
Willames M B S Martins, Ana Clara Narciso, Rodrigo Cayô, Stéfanie Vanessa Santos, Lorena C C Fehlberg, Patrícia Locosque Ramos, João Batista da Cruz, Ana Cristina Gales
The production of São Paulo metallo-β-lactamase (SPM-1) is the most common carbapenem resistance mechanism detected among multidrug-resistant Pseudomonas aeruginosa clinical isolates in Brazil. Dissemination of SPM-1-producing P. aeruginosa has been restricted to the nosocomial settings, with sporadic reports of environmental isolates due to contamination by hospital sewage. Herein, we described the detection and molecular characterization of SPM-1-producing P. aeruginosa recovered from the microbiota of migratory birds in Brazil...
November 10, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29222130/stargazin-and-cornichon-3-relieve-polyamine-block-of-ampa-receptors-by-enhancing-blocker-permeation
#17
Patricia M G E Brown, Hugo McGuire, Derek Bowie
Most ligand- and voltage-gated ion channels assemble as signaling complexes consisting of pore-forming and auxiliary subunits. In the mammalian brain, AMPA-type ionotropic glutamate receptors (AMPARs) coassemble with several families of auxiliary subunits that regulate channel gating as well as ion channel block and permeation. Previous work has shown that auxiliary proteins stargazin (or γ2) and cornichon-3 (CNIH-3) attenuate the cytoplasmic polyamine channel block of AMPARs, although the underlying mechanism has yet to be established...
December 8, 2017: Journal of General Physiology
https://www.readbyqxmd.com/read/29216471/annual-cycle-of-dimethylsulfoniopropionate-dmsp-and-dimethylsulfoxide-dmso-related-to-phytoplankton-succession-in-the-southern-north-sea
#18
Gaëlle Speeckaert, Alberto V Borges, Willy Champenois, Colin Royer, Nathalie Gypens
The influence of abiotic and biotic variables on the concentration of dimethyl sulfide (DMS), dimethylsulfoniopropionate (DMSP), and dimethylsulfoxide (DMSO), were investigated during an annual cycle in 2016 in the Belgian Coastal Zone (BCZ, North Sea). We reported strong seasonal variations in the concentration of these compounds linked to the phytoplankton succession with high DMS(P,O) producers (mainly Phaeocystis globosa) occurring in spring and low DMS(P,O) producers (various diatoms species) occurring in early spring and autumn...
December 4, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29216408/a-cold-responsive-erf-from-medicago-falcata-confers-cold-tolerance-by-up-regulation-of-polyamine-turnover-antioxidant-protection-and-proline-accumulation
#19
Chunliu Zhuo, Lu Liang, Yaqing Zhao, Zhenfei Guo, Shaoyun Lu
ERF subfamily transcription factors play an important role in plant abiotic and biotic stress tolerance. A cold responsive ethylene responsive factor (ERF), MfERF1, was isolated from Medicago falcata, an important forage legume that has great cold tolerance. Overexpression of MfERF1 resulted in an increased tolerance to freezing and chilling in transgenic tobacco plants, while down-regulation of the ortholog of MfERF1 in M. truncatula resulted in reduced freezing tolerance in RNAi plants. Higher transcript levels of some stress responsive genes (CHN50, OSM, ERD10C, and SAMS) and those involved in spermidine (Spd) and spermine (Spm) synthesis (SAMDC1, SAMDC2, SPDS1, SPDS2, and SPMS) and catabolism (PAO) were observed in transgenic plants than in WT...
December 7, 2017: Plant, Cell & Environment
https://www.readbyqxmd.com/read/29210942/auditory-related-resting-state-fmri-functional-connectivity-in-tinnitus-patients-tinnitus-diagnosis-performance
#20
Shujiro B Minami, Naoki Oishi, Takahisa Watabe, Kimiichi Uno, Kaoru Ogawa
OBJECTIVE: The purpose of the present study was to investigate functional connectivity in tinnitus patients with and without hearing loss, and design the tinnitus diagnosis performance by resting state functional magnetic resonance imaging (rs-fMRI). SUBJECTS AND METHODS: Nineteen volunteers with normal hearing without tinnitus, 18 tinnitus patients with hearing loss, and 11 tinnitus patients without hearing loss were enrolled in this study. The subjects were evaluated with rs-fMRI, and region of interests (ROIs) based correlation analyses were performed using the CONN toolbox version 16 and SPM version 8...
November 28, 2017: Otology & Neurotology
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