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Shun Zhou, Jian Gu, Rui Liu, Song Wei, Qi Wang, Hongbing Shen, Yifan Dai, Haoming Zhou, Feng Zhang, Ling Lu
Liver-resident macrophages (Kupffer cells, KCs) and autophagy play critical roles in the pathogenesis of toxin-induced liver injury. Recent evidence indicates that autophagy can regulate macrophage M1/M2 polarization under different inflammatory conditions. Polyamines, including putrescine, spermidine, and spermine (SPM), are polycations with anti-oxidative, anti-aging, and cell autophagy induction properties. This study aimed to determine the mechanisms by which SPM protects against thioacetamide (TAA)-induced acute liver injury in a mouse model...
2018: Frontiers in Immunology
Samuel J Callaghan, Robert G Lockie, Warren A Andrews, Robert F Chipchase, Sophia Nimphius
This study assessed the reliability and validity of segment measured accelerations in comparison to front foot contact (FFC) ground reaction force (GRF) during the delivery stride for cricket pace bowlers. Eleven recreational bowlers completed a 30-delivery bowling spell. Trunk- and tibia-mounted inertial measurement units (IMUs) were used to measure accelerations, converted to force, for comparisons to force plate GRF discrete measures. These measures included peak force, impulse and the continuous force-time curve in the vertical and braking (horizontal) planes...
May 16, 2018: Sports Biomechanics
Rene Seiger, Sebastian Ganger, Georg S Kranz, Andreas Hahn, Rupert Lanzenberger
BACKGROUND AND PURPOSE: Automated cortical thickness (CT) measurements are often used to assess gray matter changes in the healthy and diseased human brain. The FreeSurfer software is frequently applied for this type of analysis. The computational anatomy toolbox (CAT12) for SPM, which offers a fast and easy-to-use alternative approach, was recently made available. METHODS: In this study, we compared region of interest (ROI)-wise CT estimations of the surface-based FreeSurfer 6 (FS6) software and the volume-based CAT12 toolbox for SPM using 44 elderly healthy female control subjects (HC)...
May 15, 2018: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
Prachi Shenai-Tirodkar, Mangesh Gauns, Girish Kumar, Zakir Ansari
This study aimed to evaluate the relationship between physicochemical parameters and heavy metal (Cu, Ni, Pb, and Cd) concentrations from sediment, seawater, and its accumulation in tissues of oyster species (Crassostrea madrasensis and C. gryphoides) from the three sites (Chicalim Bay (CB), Nerul Creek (NC), Chapora Bay (ChB)) along the Goa coast (India). Results showed enrichment of Cu and Ni in sediment exceeding the effect range low (ERL) level. The higher concentrations of Cu and Ni in sediments and in suspended particulate matter (SPM) from all the study sites are indicative of severe contamination of estuarine and associated habitats...
May 15, 2018: Environmental Science and Pollution Research International
Joseph Vamecq, Pierre Andreoletti, Riad El Kebbaj, Fatima-Ezzahra Saih, Norbert Latruffe, M' Hammed Saïd El Kebbaj, Gérard Lizard, Boubker Nasser, Mustapha Cherkaoui-Malki
To clarify appropriateness of current claims for health and wellness virtues of argan oil, studies were conducted in inflammatory states. LPS induces inflammation with reduction of PGC1- α signaling and energy metabolism. Argan oil protected the liver against LPS toxicity and interestingly enough preservation of peroxisomal acyl-CoA oxidase type 1 (ACOX1) activity against depression by LPS. This model of LPS-driven toxicity circumvented by argan oil along with a key anti-inflammatory role attributed to ACOX1 has been here transposed to model aging...
2018: Oxidative Medicine and Cellular Longevity
Linlin Zhang, Niccolò Terrando, Zhen-Zhong Xu, Sangsu Bang, Sven-Eric Jordt, William Maixner, Charles N Serhan, Ru-Rong Ji
Mechanisms of pain resolution are largely unclear. Increasing evidence suggests that specialized pro-resolving mediators (SPMs), derived from fish oil docosahexaenoic acid (DHA), promote the resolution of acute inflammation and potently inhibit inflammatory and neuropathic pain. In this study, we examined the analgesic impact of DHA and DHA-derived SPMs in a mouse model of post-operative pain induced by tibial bone fracture (fPOP). Intravenous perioperative treatment with DHA (500 μg), resolvin D1 (RvD1, 500 ng) and maresin 1 (MaR1, 500 ng), 10 min and 24 h after the surgery, delayed the development of fPOP (mechanical allodynia and cold allodynia)...
2018: Frontiers in Pharmacology
Jianhe Wang, Jing Wang, Lian-Hui Zhang
Pseudomonas aeruginosa is known to cause life-threatening infections. The previous studies showed that the type III secretion system (T3SS) of this pathogen is a key virulence determinant, which is activated by polyamines signals spermidine (Spd) and spermine (Spm) from mammalian host. To test the potential of blocking host-pathogen communication in disease control, in this study we developed a high potency mouse monoclonal antibody (Mab 4E4, IgG1 sub-isotype) by using Spm-protein conjugate as an immunogen...
May 14, 2018: Microbial Biotechnology
M Masson, H Angot, C Le Bescond, M Launay, A Dabrin, C Miège, J Le Coz, M Coquery
Monitoring hydrophobic contaminants in surface freshwaters requires measuring contaminant concentrations in the particulate fraction (sediment or suspended particulate matter, SPM) of the water column. Particle traps (PTs) have been recently developed to sample SPM as cost-efficient, easy to operate and time-integrative tools. But the representativeness of SPM collected with PTs is not fully understood, notably in terms of grain size distribution and particulate organic carbon (POC) content, which could both skew particulate contaminant concentrations...
May 10, 2018: Science of the Total Environment
Xiangyu Xu, Xuyan Mao, Yunfei Wang, Dandan Li, Zhongyu Du, Weihua Wu, Liang Jiang, Jie Yang, Jianjun Li
The interaction between graphene oxide-sliver nanocomposites (GO-AgNCPs) and bovine serum albumin (BSA) in aqueous buffer solution was investigated by using several spectroscopic and imaging techniques. The visible absorbance intensity of GO-AgNCPs increased with increasing concentrations of BSA, and a slight redshift of the surface plasmon resonance band (SPR) occurred due to the absorption of BSA on the surface of GO-AgNCPs. Fluorescence data revealed a static quenching process of BSA caused by GO-AgNCPs...
May 9, 2018: International Journal of Biological Macromolecules
Chiharu Kai, Yoshikazu Uchiyama, Junji Shiraishi, Hiroshi Fujita, Kunio Doi
In the post-genome era, a novel research field, 'radiomics' has been developed to offer a new viewpoint for the use of genotypes in radiology and medicine research which have traditionally focused on the analysis of imaging phenotypes. The present study analyzed brain morphological changes related to the individual's genotype. Our data consisted of magnetic resonance (MR) images of patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD), as well as their apolipoprotein E (APOE) genotypes...
May 10, 2018: Radiological Physics and Technology
Jens Gisselgård, Alexander V Lebedev, Kathinka Dæhli Kurz, Inge Joa, Jan Olav Johannessen, Kolbjørn Brønnick
Several previous studies suggest that clinical high risk for psychosis (CHR) is associated with prefrontal functional abnormalities and more widespread reduced grey matter in prefrontal, temporal and parietal areas. We investigated neural correlates to CHR in medication-naïve patients. 41 CHR patients and 37 healthy controls were examined with 1.5 Tesla MRI, yielding functional scans while performing an N-back task and structural T1-weighted brain images. Functional and structural data underwent automated preprocessing steps in SPM and Freesurfer, correspondingly...
2018: PloS One
Marisete M Welter, Saskia Jaarsveld, Thomas Lachmann
We studied the development of cognitive abilities related to intelligence and creativity ( N = 48, 6-10 years old), using a longitudinal design (over one school year), in order to evaluate an Enrichment Program for gifted primary school children initiated by the government of the German federal state of Rhineland-Palatinate ( Entdeckertag Rheinland Pfalz , Germany; ET; Day of Discoverers). A group of German primary school children ( N = 24), identified earlier as intellectually gifted and selected to join the ET program was compared to a gender-, class- and IQ- matched group of control children that did not participate in this program...
2018: Frontiers in Psychology
Liang-Saw Wen, Chih-Ping Lee, Wen-Huei Lee, Alan Chuang
The distributions of many trace elements in the ocean are strongly associated with the growth, death, and re-mineralization of marine plankton and those of suspended/sinking particles. Here, we present an all plastic (Polypropylene and Polycarbonate), multi-layer filtration system for collection of suspended particulate matter (SPM) at sea. This ultra-clean sampling device has been designed and developed specifically for trace element studies. Meticulous selection of all non-metallic materials and utilization of an in-line flow-through procedure minimizes any possible metal contamination during sampling...
April 19, 2018: Journal of Visualized Experiments: JoVE
Anton Albajes-Eizagirre, Joaquim Radua
Coordinate-based meta-analyses (CBMA) methods, such as Activation Likelihood Estimation (ALE) and Seed-based d Mapping (SDM), have become an invaluable tool for summarizing the findings of voxel-based neuroimaging studies. However, the progressive sophistication of these methods may have concealed two particularities of their statistical tests. Common univariate voxelwise tests (such as the t/z-tests used in SPM and FSL) detect voxels that activate, or voxels that show differences between groups. Conversely, the tests conducted in CBMA test for "spatial convergence" of findings, i...
May 2, 2018: NeuroImage
A L M Batista de Carvalho, S F Parker, L A E Batista de Carvalho, M P M Marques
The introduction of cisplatin to oncology, in the 1970s, marked the onset of the search for novel and improved metal-based anticancer drugs. Polynuclear PtII and PdII complexes with linear alkylamines as bridging ligands are a class of potential antineoplastic agents that have shown promising cytotoxicity against low-prognosis human cancers, such as metastatic breast adenocarcinoma and osteosarcoma. The present study reports an analysis of [μ-N,N'-bis(3-aminopropyl)butane-1,4-diamine-κ4 N,N':N'',N''']bis[dichloridoplatinum(II)], [Pt2 Cl4 (C10 H26 N4 )], denoted Pt2 Spm (Spm is spermine), by vibrational spectroscopy coupled to theoretical calculations...
May 1, 2018: Acta Crystallographica. Section C, Structural Chemistry
Nandini Krishnamoorthy, Raja-Elie E Abdulnour, Katherine H Walker, Braden D Engstrom, Bruce D Levy
Airborne pathogens and environmental stimuli evoke immune responses in the lung. It is critical to health that these responses be controlled to prevent tissue damage and the compromise of organ function. Resolution of inflammation is a dynamic process that is coordinated by biochemical and cellular mechanisms. Recently, specialized proresolving mediators (SPMs) have been identified in resolution exudates. These molecules orchestrate anti-inflammatory and proresolving actions that are cell type specific. In this review, we highlight SPM biosynthesis, the influence of SPMs on the innate and adaptive immune responses in the lung, as well as recent insights from SPMs on inflammatory disease pathophysiology...
July 1, 2018: Physiological Reviews
Jun Zhao, Wenxi Cao, Zhantang Xu, Haibin Ye, Yuezhong Yang, Guifen Wang, Wen Zhou, Zhaohua Sun
An empirical algorithm is proposed to estimate suspended particulate matter (SPM) ranging from 0.675 to 25.7 mg L-1 in the turbid Pearl River estuary (PRE). Comparisons between model predicted and in situ measured SPM resulted in R2 s of 0.97 and 0.88 and mean absolute percentage errors (MAPEs) of 23.96% and 29.69% by using the calibration and validation data sets, respectively. The developed algorithm demonstrated the highest accuracy when compared with existing ones for turbid coastal waters. The diurnal dynamics of SPM was revealed by applying the proposed algorithm to reflectance data collected by a moored buoy in the PRE...
April 16, 2018: Optics Express
Yafei Luo, David Doxaran, Kevin Ruddick, Fang Shen, Bernard Gentili, Liwen Yan, Haijun Huang
Evidence of water reflectance saturation in extremely turbid media is highlighted based on both field measurements and satellite data corrected for atmospheric effects. This saturation is obvious in visible spectral bands, i.e., in the blue, green and even red spectral regions when the concentration of suspended particulate matter (SPM) reaches then exceeds 100 to 1000 g.m-3 . The validity of several bio-optical semi-analytical models is assessed in the case of highly turbid waters, based on comparisons with outputs of the Hydrolight radiative transfer model...
April 16, 2018: Optics Express
Loredana Storelli, Maria A Rocca, Elisabetta Pagani, Wim Van Hecke, Mark A Horsfield, Nicola De Stefano, Alex Rovira, Jaume Sastre-Garriga, Jacqueline Palace, Diana Sima, Dirk Smeets, Massimo Filippi
Purpose To compare available methods for whole-brain and gray matter (GM) atrophy estimation in multiple sclerosis (MS) in terms of repeatability (same magnetic resonance [MR] imaging unit) and reproducibility (different system/field strength) for their potential clinical applications. Materials and Methods The softwares ANTs-v1.9, CIVET-v2.1, FSL-SIENAX/SIENA-5.0.1, Icometrix-MSmetrix-1.7, and SPM-v12 were compared. This retrospective study, performed between March 2015 and March 2017, collected data from (a) eight simulated MR images and longitudinal data (2 weeks) from 10 healthy control subjects to assess the cross-sectional and longitudinal accuracy of atrophy measures, (b) test-retest MR images in 29 patients with MS acquired within the same day at different imaging unit field strengths/manufacturers to evaluate precision, and (c) longitudinal data (1 year) in 24 patients with MS for the agreement between methods...
May 27, 2018: Radiology
Haomiao Cheng, Zulin Hua
Since tetrabromobisphenol A (TBBPA) has been increasingly used and found widely in the aquatic environment, it has attracted much attention due to its high toxicity to aquatic organisms. However, less work has been carried out for the TBBPA environmental fate in water-sediment systems. In this paper, the distribution, release and removal of TBBPA in different forms of the water-sediment system were investigated under three typical hydrodynamic conditions using a specialized racetrack-style flume. Three water-sediment systems which are water, suspended particulate matter (SPM) and sediment were taken into account in this study...
April 27, 2018: Science of the Total Environment
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