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M Linard, B Blondel, C Estellat, C Deneux-Tharaux, D Luton, J F Oury, T Schmitz, L Mandelbrot, E Azria
OBJECTIVE: Because the effectiveness of antenatal care in reducing pregnancy complications is still discussed despite widespread recommendations of its use, we sought to assess the association between utilisation of recommended antenatal care and severe maternal (SMM) and perinatal morbidity (SPM). DESIGN: Prospective cohort study. SETTING: Four maternity units around Paris in 2010-2012. SAMPLE: 9117 women with singleton pregnancies...
June 20, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
Rute Cesário, Laurier Poissant, Martin Pilote, Nelson J O'Driscoll, Ana M Mota, João Canário
Intertidal sediments of Tagus estuary regularly experiences complex redistribution due to tidal forcing, which affects the cycling of mercury (Hg) between sediments and the water column. This study quantifies total mercury (Hg) and methylmercury (MMHg) concentrations and fluxes in a flooded mudflat as well as the effects on water-level fluctuations on the air-surface exchange of mercury. A fast increase in dissolved Hg and MMHg concentrations was observed in overlying water in the first 10min of inundation and corresponded to a decrease in pore waters, suggesting a rapid export of Hg and MMHg from sediments to the water column...
June 16, 2017: Science of the Total Environment
M Kölln, A Loi-Brügger, J Kamphues
Foot pad dermatitis (FPD) is of great concern in poultry industry, and dietary strategies are needed to improve foot pad health because of animal welfare and economic reasons. As the main factor for the development of FPD is the DM content of litter (consisting mainly of excreta; Kamphues et al., 2011), there are different dietary approaches to influence this disease pattern. In two consecutive trials, a total of 200 broilers were kept from day 7 until the 35th day of life. They were divided into four groups at each trial and fed with one of four experimental diets, based on wheat and corn mainly, but differing in the protein source: Group 1 was fed a diet with soya bean meal (SBM) as the main protein source, whereas Group 2, Group 3 and Group 4 were assigned to diets with 4, 8 and 12% of a protein-rich (66...
June 2017: Journal of Animal Physiology and Animal Nutrition
Heinz Rüdel, Josef Müller, Jens Nowak, Mathias Ricking, Roland Klein, Matthias Kotthoff
The brominated flame retardant hexabromocyclododecane (HBCD) was monitored in fish and sediment (from one lake) or suspended particulate matter (SPM; from five rivers) at European freshwater sites to study the effects of reduction measures implemented by HBCD producers and users in recent years. Bream (Abramis brama) were sampled annually between 2007 and 2013 in the rivers Götaälv/SE, Rhône/FR, Western Scheldt/NL, Mersey/UK, and Tees/UK and in Lake Belau/DE. Sediment/SPM was taken every second year between 2008 and 2014...
June 17, 2017: Environmental Science and Pollution Research International
Karla Viridiana Castro-Cerritos, Adolfo Lopez-Torres, Armando Obregón-Herrera, Katarzyna Wrobel, Kazimierz Wrobel, Mario Pedraza-Reyes
The non-appropriate conditions faced by nutritionally stressed bacteria propitiate error-prone repair events underlying stationary-phase- or stress-associated mutagenesis (SPM). The genetic and molecular mechanisms involved in SPM have been deeply studied but the biochemical aspects of this process have so far been less explored. Previous evidence showed that under conditions of nutritional stress, non-dividing cells of strain B. subtilis YB955 overexpressing ribonucleotide reductase (RNR) exhibited a strong propensity to generate true reversions in the hisC952 (amber), metB5 (ochre) and leuC425 (missense) mutant alleles...
June 17, 2017: Current Genetics
Joe L P Kolkert, Rolf H H Groenwold, Vanessa J Leijdekkers, Joep Ter Haar, Clark J Zeebregts, Anco Vahl
BACKGROUND: Arterial shunting during carotid endarterectomy (CEA) is essential in some patients because of insufficient cerebral perfusion during cross-clamping. However, the optimal diagnostic modality identifying these patients is still debated. None of the currently used modalities has been proved superior to another. The aim of this study was to assess the cost-effectiveness of two modalities, stump pressure measurement (SPM) versus electroencephalography (EEG) combined with transcranial Doppler (TCD) during CEA...
June 16, 2017: World Journal of Surgery
Ruie Lu, Sen Yang, Yitong Li, Kaiyun Chen, Yun Jiang, Bi Fu, Yin Zhang, Chao Zhou, Minwei Xu, Xuan Zhou
The glassy transition of superparamagnetic (SPM) (r < r0) nanoparticle systems usually occurs at a very low temperature that greatly limits its application to high temperatures. In this work, we report a spin-glass-like (SGL) behavior near the Curie point (TC), i.e., T0 = 330 K, in La0.67Sr0.33MnO3 (LSMO) nanofibers (NFs) composed of nanoparticles beyond the SPM size (r ≫ r0), resulting in a significant increase of the glass transition temperature. This SGL transition near the TC of bulk LSMO can be explained to be the scenario of locally ordered clusters embedded in a disordered host, in which the assembly of nanoparticles has a magnetic core-shell model driven by surface spin glass...
June 16, 2017: Physical Chemistry Chemical Physics: PCCP
Liang Ma, Wenjun Zhang, Yiguang Zhu, Guangtao Zhang, Haibo Zhang, Qingbo Zhang, Liping Zhang, Chengshan Yuan, Changsheng Zhang
Tryptophan dimers (TDs) are an important class of natural products with diverse bioactivities and share conserved biosynthetic pathways. We report the identification of a partial gene cluster (spm) responsible for the biosynthesis of a class of unusual TDs with non-planar skeletons including spiroindimicins (SPMs), indimicins (IDMs), and lynamicins (LNMs) from the deep-sea derived Streptomyces sp. SCSIO 03032. Bioinformatics analysis, targeted gene disruptions, and heterologous expression studies confirmed the involvement of the spm gene cluster in the biosynthesis of SPM/IDM/LNMs, and revealed the indispensable roles for the halogenase/reductase pair SpmHF, the amino acid oxidase SpmO, and the chromopyrrolic acid (CPA) synthase SpmD, as well as the positive regulator SpmR and the putative transporter SpmA...
June 15, 2017: Applied Microbiology and Biotechnology
Xianfa Su, Qilu Li, Jinglan Feng, Liya Guo, Jianhui Sun
Halogenated flame retardants (HFRs), mainly encompassing polybrominated diphenylethers (PBDEs), dechlorane plus (DP) and emerging bromine flame retardants (EBFRs), are widely employed nowadays in daily lives. However, limited knowledge has been gained to date on the concentrations and distributions of HFRs in particular within certain regions. In the present study, legacy and emerging HFRs were systematically measured in suspended particle matter (SPM) and sediments collected in 2014 from the middle and lower reach of the Yellow River in Henan province...
June 9, 2017: Science of the Total Environment
Néstor Rubio-Infante, Damaris Ilhuicatzi-Alvarado, Marilu Torres-Martínez, Juan Pablo Reyes-Grajeda, Raúl Nava-Acosta, Edith González-González, Leticia Moreno-Fierros
Here, we aimed to further characterize the mechanisms involved in protoxin (p) Cry1Ac-induced macrophage activation. We demonstrated that pCry1Ac induces MAPK ERK1/2, p38 and JNK phosphorylation in RAW264.7 macrophages. Because MAPK activation is mainly triggered via ligand-receptor interactions, we focused on the identification of potential pCry1Ac-receptor proteins. Flow cytometry and confocal analysis showed specific saturable pCry1Ac-binding to the macrophage surface and evidenced its internalization via the clathrin-pathway...
June 13, 2017: Journal of Cellular Biochemistry
Un-Jung Kim, Jung Keun Oh, Kurunthachalam Kannan
The occurrence and fate of 14 triester organophosphate flame retardants (OPFRs) and plasticizers and their two diester metabolites were investigated in a wastewater treatment plant (WWTP) in the Albany area of New York State. All target OPFRs were found in wastewater, with average concentrations that ranged from 20.1 ng/L for tris(methylphenyl) phosphate (TMPP) to 30100 ng/L for tris(2-butoxyethyl)phosphate (TBOEP) in influents and from 7.68 ng/L for TMPP to 12600 ng/L for TBOEP in final effluents. TBOEP was the dominant compound in influents (max: 69500 ng/L) followed in decreasing order by tris(1-chloro-2-propyl)phosphate (TCIPP; max: 14500 ng/L), bis(1,3-dichloro-2-propyl)phosphate (BDCIPP; max: 4550 ng/L), tris(1,3-dichloro-2-propyl)phosphate (TDCIPP; max: 3150 ng/L) and tris(2-chloroethyl)phosphate (TCEP; max: 8450 ng/L)...
June 12, 2017: Environmental Science & Technology
Larissa A Habib, Jasmine H Francis, Armida Wm Fabius, Pierre Y Gobin, Ira J Dunkel, David H Abramson
BACKGROUND/AIMS: Survivors of retinoblastoma carry a lifetime risk of secondary malignancies. It is well established that external beam radiation increases this risk; however, the risk with ophthalmic artery chemosurgery (OAC) remains unknown. We report on 10 years of experience with OAC and the rate of second primary malignancy (SPM) development. METHODS: This is a single-centre retrospective review approved by the Memorial Sloan Kettering Cancer Center Institutional Review Board of all patients who received OAC over a 10-year period, from May 2006 to November 2016...
June 9, 2017: British Journal of Ophthalmology
Ping Hu, Shun Dong, Xinghong Zhang, Kaixuan Gui, Guiqing Chen, Ze Hu
Several-millimeter long SiC nanowires (NWs) with unique optical properties, excellent thermal stability and flexible nanomechanical properties were synthesized using a simple method with silicon and phenolic resin as the raw materials. The SiC NWs displayed special optical properties that were attributed to their large size and Al-doping. They displayed broad green emission at 527.8 nm (2.35 eV) and purple emission concentrated at 438.9 nm (2.83 eV), in contrast to the other results, and the synthesized SiC NWs could also remain relatively stable in air up to 1000 °C indicating excellent thermal stability...
June 7, 2017: Scientific Reports
J David Christopher, Rajni B Patel, Jolyon P Mitchell, Terrence P Tougas, Adrian P Goodey, Jorge Quiroz, Patrik U Andersson, Svetlana Lyapustina
This article reports on results from a two-lab, multiple impactor experiment evaluating the abbreviated impactor measurement (AIM) concept, conducted by the Cascade Impaction Working Group of the International Pharmaceutical Aerosol Consortium on Regulation and Science (IPAC-RS). The goal of this experiment was to expand understanding of the performance of an AIM-type apparatus based on the Andersen eight-stage non-viable cascade impactor (ACI) for the assessment of inhalation aerosols and sprays, compared with the full-resolution version of that impactor described in the pharmacopeial compendia...
June 6, 2017: AAPS PharmSciTech
Jian Hu, Congqiang Liu, Qingjun Guo, Junxin Yang, Chukwunonso Peter Okoli, Yunchao Lang, Zhiqi Zhao, Siliang Li, Baojian Liu, Guangwei Song
The concentration characteristics, sources, and potential ecological risk assessment of 16 PAHs were investigated in the surface water from the Songhua River Basin, Northeast China. A total of 48 river water samples, including 16 from the main streams and 32 from the tributaries, were collected. Samples were separated into dissolved phases and suspended particle matter (SPM) via filtration with 0.47 μm glass fiber filters. Each phase was analyzed for PAHs. The total PAH concentration in the dissolved phase in the water ranged from 32...
June 5, 2017: Environmental Science and Pollution Research International
Ha Yeon Kim, Eun Joo Kim, Joshua Sung H You
BACKGROUND: An improved understanding of the mechanisms underlying locomotor networks has the potential to benefit the neurorehabilitation of patients with neurological locomotor deficits. However, the specific locomotor networks that mediate adaptive locomotor performance and changes in gait speed remain unknown. OBJECTIVE: The aim of the present study was to examine patterns of cortical activation associated with the walking speeds of 1.5, 2.0, 2.5, and 3.0 km/h on a treadmill...
May 19, 2017: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
Renat Yakupov, Juan Lei, Michael Hoffmann, Oliver Speck
Motion correction of echo-planar imaging (EPI) data used in functional MRI (fMRI) is an essential preprocessing step performed prior to statistical analysis. At ultra-high resolution fMRI, current requirements regarding translational and rotational motion may no longer be acceptable. This prompts the need for a systematic investigation of the effects of motion correction procedures with in vivo fMRI data. Here we systematically evaluated the effect of retrospective motion correction with freely available fMRI analysis software packages (FSL, AFNI, and SPM) on activation maps using fMRI data acquired with prospective motion detection, to identify and quantify confounding effects of retrospective motion correction, and to evaluate its dependence on spatial resolution and motion correction algorithms...
June 5, 2017: Human Brain Mapping
Xixi Wang, Jiejin Zhang, Yongsheng Yuan, Tiannv Li, Li Zhang, Jian Ding, Siming Jiang, Junyi Li, Lin Zhu, Kezhong Zhang
OBJECT: To detect the cerebral metabolic bases of Parkinson's disease (PD) patients with anxiety. METHODS: Totally 28 idiopathic PD patients without depression (17-item Hamilton Depression Rating Scale, HAMD score <14) were enrolled in our study. All subjects were classified into PD with anxiety (PD-A) (n=13) and PD without anxiety (PD-NA) (n=15) by cutoff score of 11 according to Hamilton Anxiety Rating Scale (HAMA). Besides, age- and gender- matched healthy controls (HCs) (n=15) were selected...
June 1, 2017: Neuroscience Letters
E Conca, M Malandrino, A Giacomino, S Buoso, S Berto, P L Verplanck, E Magi, O Abollino
Water and Suspended Particulate Material (SPM) samples analysed in this work were collected in the austral summer 2011/12 from six shallow Antarctic lakes (Carezza, Edmonson Point 14 and 15a, Gondwana, Inexpressible Island 10b and Tarn Flat 20) of Terra Nova Bay (Northern Victoria Land, Antarctica). The total concentrations of a large suite of inorganic analytes were determined, in order to gain insight into the natural processes regulating species distribution, define natural background values and detect possible present or future local and/or global anthropogenic contamination...
May 20, 2017: Chemosphere
J A Taylor, N Matthews, P T Michie, M J Rosa, M I Garrido
Schizophrenia is a complex psychiatric disorder, typically diagnosed through symptomatic evidence collected through patient interview. We aim to develop an objective biologically-based computational tool which aids diagnosis and relies on accessible imaging technologies such as electroencephalography (EEG). To achieve this, we used machine learning techniques and a combination of paradigms designed to elicit prediction errors or Mismatch Negativity (MMN) responses. MMN, an EEG component elicited by unpredictable changes in sequences of auditory stimuli, has previously been shown to be reduced in people with schizophrenia and this is arguably one of the most reproducible neurophysiological markers of schizophrenia...
2017: NeuroImage: Clinical
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