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https://www.readbyqxmd.com/read/28087294/bioactive-metabolites-of-docosahexaenoic-acid
#1
REVIEW
Ondrej Kuda
Docosahexaenoic acid (DHA) is an essential fatty acid that is recognized as a beneficial dietary constituent and as a source of the anti-inflammatory specialized proresolving mediators (SPM): resolvins, protectins and maresins. Apart from SPMs, other metabolites of DHA also exert potent biological effects. This article summarizes current knowledge on the metabolic pathways involved in generation of DHA metabolites. Over 70 biologically active metabolites have been described, but are often discussed separately within specific research areas...
January 10, 2017: Biochimie
https://www.readbyqxmd.com/read/28079976/maresin-1-induces-a-novel-pro-resolving-phenotype-in-human-platelets
#2
Katie L Lannan, Sherry L Spinelli, Neil Blumberg, Richard P Phipps
BACKGROUND: Antiplatelet therapy is a cornerstone of modern medical practice and is routinely employed to reduce the likelihood of myocardial infarction, thrombosis, and stroke. However, current antiplatelet therapies, such as aspirin, often have adverse side effects, including increased risk of bleeding, and some patients are relatively "aspirin-resistant". Platelets are intimately involved in hemostasis and inflammation, and clinical consequences are associated with excessive or insufficient platelet activation...
January 12, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28077210/spatial-temporal-and-multi-media-variations-of-polycyclic-aromatic-hydrocarbons-in-a-highly-urbanized-river-from-south-china
#3
Di Zhang, Jun-Jian Wang, Hong-Gang Ni, Hui Zeng
Comprehensive studies on polycyclic aromatic hydrocarbons (PAHs) within an urban river are urgently needed to carry out strategies to limit their contamination and dispersal. Here, we analyzed 16 PAH occurrences in water, suspended particulate matter (SPM), and sediment monthly for a year in the Maozhou River mainstream (Shenzhen, South China). Monthly rainfall positively correlated with both total PAH concentrations in filtered water (water PAHs) and SPM. Sediment PAH concentration increased from the river source to estuary...
January 8, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28073029/multiplexed-efficient-on-chip-sample-preparation-and-sensitive-amplification-free-detection-of-ebola-virus
#4
K Du, H Cai, M Park, T A Wall, M A Stott, K J Alfson, A Griffiths, R Carrion, J L Patterson, A R Hawkins, H Schmidt, R A Mathies
An automated microfluidic sample preparation multiplexer (SPM) has been developed and evaluated for Ebola virus detection. Metered air bubbles controlled by microvalves are used to improve bead-solution mixing thereby enhancing the hybridization of the target Ebola virus RNA with capture probes bound to the beads. The method uses thermally stable 4-formyl benzamide functionalized (4FB) magnetic beads rather than streptavidin coated beads with a high density of capture probes to improve the target capture efficiency...
January 3, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28072386/main-effects-and-interactions-of-cerebral-hemispheres-gender-and-age-in-the-calculation-of-volumes-and-asymmetries-of-selected-structures-of-episodic-memory
#5
Rocio Ramirez-Carmona, Haydee Guadalupe Garcia-Lazaro, Brenda Dominguez-Corrales, Erika Aguilar-Castañeda, Ernesto Roldan-Valadez
The aim of this study was to clarify the influence of anatomical (cerebral hemisphere) and demographic (age and gender) variables on the gray matter (GM) volumes and volumetric asymmetry indices (VAIs) of selected structures involved in episodic memory. A cross-sectional study was performed in 47 healthy volunteers. Neuropsychological evaluation revealed similar IQs across the sample. Using SPM-based software, brain segmentation, labeling and volume measurements of the hippocampus, amygdala, middle temporal gyrus and parahippocampal gyrus were performed in each cerebral hemisphere...
October 2016: Functional Neurology
https://www.readbyqxmd.com/read/28063108/validation-of-18-f-fdg-pet-single-subject-optimized-spm-procedure-with-different-pet-scanners
#6
Luca Presotto, Tommaso Ballarini, Silvia Paola Caminiti, Valentino Bettinardi, Luigi Gianolli, Daniela Perani
(18)F-fluoro-deoxy-glucose Positron Emission Tomography (FDG-PET) allows early identification of neurodegeneration in dementia. The use of an optimized method based on the SPM software package highly improves diagnostic accuracy. However, the impact of different scanners for data acquisition on the SPM results and the effects of different pools of healthy subjects on the statistical comparison have not been investigated yet. Images from 144 AD patients acquired using six different PET scanners were analysed with an optimized single-subject SPM procedure to identify the typical AD hypometabolism pattern at single subject level...
January 6, 2017: Neuroinformatics
https://www.readbyqxmd.com/read/28056109/postural-ataxia-in-cerebellar-downbeat-nystagmus-its-relation-to-visual-proprioceptive-and-vestibular-signals-and-cerebellar-atrophy
#7
Christoph Helmchen, Jan-Birger Kirchhoff, Martin Göttlich, Andreas Sprenger
BACKGROUND: The cerebellum integrates proprioceptive, vestibular and visual signals for postural control. Cerebellar patients with downbeat nystagmus (DBN) complain of unsteadiness of stance and gait as well as blurred vision and oscillopsia. OBJECTIVES: The aim of this study was to elucidate the differential role of visual input, gaze eccentricity, vestibular and proprioceptive input on the postural stability in a large cohort of cerebellar patients with DBN, in comparison to healthy age-matched control subjects...
2017: PloS One
https://www.readbyqxmd.com/read/28048262/su-g-iep1-07-inaccuracy-of-lesion-blood-flow-quantification-related-to-the-proton-density-reference-image-in-arterial-spin-labeling-mri-of-brain-tumors
#8
M Jen, J Johnson, P Hou, H Liu
PURPOSE: Cerebral blood flow quantification in arterial spin labeling (ASL) MRI requires an estimate of the equilibrium magnetization of blood, which is often obtained by a set of proton density (PD) reference image. Normally, a constant blood-brain partition coefficient is assumed across the brain. However, this assumption may not be valid for brain lesions. This study aimed to evaluate the impact of lesion-related PD variations on ASL quantification in patients with brain tumors. METHODS: MR images for posttreatment evaluation of 42 patients with brain tumors were retrospectively analyzed...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047024/su-d-207a-07-the-effects-of-inter-cycle-respiratory-motion-variation-on-dose-accumulation-in-single-fraction-mr-guided-sbrt-treatment-of-renal-cell-carcinoma
#9
B Stemkens, M Glitzner, C Kontaxis, B Denis de Senneville, F Prins, Spm Crijns, L Kerkmeijer, J Lagendijk, Cat van den Berg, Rhn Tijssen
PURPOSE: To assess the dose deposition in simulated single-fraction MR-Linac treatments of renal cell carcinoma, when inter-cycle respiratory motion variation is taken into account using online MRI. METHODS: Three motion characterization methods, with increasing complexity, were compared to evaluate the effect of inter-cycle motion variation and drifts on the accumulated dose for an SBRT kidney MR-Linac treatment: 1) STATIC, in which static anatomy was assumed, 2) AVG-RESP, in which 4D-MRI phase-volumes were time-weighted, based on the respiratory phase and 3) PCA, in which 3D volumes were generated using a PCA-model, enabling the detection of inter-cycle variations and drifts...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28039768/analysis-of-three-dimensional-knee-kinematics-during-stair-descent-two-decades-post-acl-rupture-data-revisited-using-statistical-parametric-mapping
#10
Gisela Sole, Todd Pataky, Eva Tengman, Charlotte Häger
Changes in movement patterns following knee injuries have generally used analyses of pre-defined discrete event-related variables, whereas Statistical Parametric Mapping (SPM) assesses continuous data over time. We applied SPM to test differences for knee trajectories during stair descent between participants with past anterior cruciate ligament (ACL) rupture who underwent reconstruction or only physical therapy compared to healthy controls. Three-dimensional knee joint kinematics during stair descent were registered for 31 subjects with ACL reconstruction (ACLR), 36 subjects with ACL rupture managed with physical therapy only (ACLPT) (∼23years post-injury), and 32 uninjured controls...
December 20, 2016: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/28039094/petpve12-an-spm-toolbox-for-partial-volume-effects-correction-in-brain-pet-application-to-amyloid-imaging-with-av45-pet
#11
Gabriel Gonzalez-Escamilla, Catharina Lange, Stefan Teipel, Ralph Buchert, Michel J Grothe
Positron emission tomography (PET) allows detecting molecular brain changes in vivo. However, the accuracy of PET is limited by partial volume effects (PVE) that affects quantitative analysis and visual interpretation of the images. Although PVE-correction methods have been shown to effectively increase the correspondence of the measured signal with the true regional tracer uptake, these procedures are still not commonly applied, neither in clinical nor in research settings. Here, we present an implementation of well validated PVE-correction procedures as a SPM toolbox, PETPVE12, for automated processing...
December 28, 2016: NeuroImage
https://www.readbyqxmd.com/read/28035613/elucidation-of-the-tidal-influence-on-bacterial-populations-in-a-monsoon-influenced-estuary-through-simultaneous-observations
#12
Lidita Khandeparker, Ranjith Eswaran, Laxman Gardade, Nishanth Kuchi, Kaushal Mapari, Sneha D Naik, Arga Chandrashekar Anil
The influence of tides on bacterial populations in a monsoon influenced tropical estuary was assessed through fine resolution sampling (1 to 3 h) during spring and neap tides from mouth to the freshwater end at four stations during pre-monsoon, monsoon and post-monsoon seasons. Higher abundance of total bacterial count (TBC) in surface water near the river mouth, compared to the upstream, during pre-monsoon was followed by an opposite scenario during the monsoon When seasonally compared, it was during the post-monsoon season when TBC in surface water was highest, with simultaneous decrease in their count in the river sediment...
January 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28018994/integrative-analysis-of-cellular-morphometric-context-reveals-clinically-relevant-signatures-in-lower-grade-glioma
#13
Ju Han, Yunfu Wang, Weidong Cai, Alexander Borowsky, Bahram Parvin, Hang Chang
Integrative analysis based on quantitative representation of whole slide images (WSIs) in a large histology cohort may provide predictive models of clinical outcome. On one hand, the efficiency and effectiveness of such representation is hindered as a result of large technical variations (e.g., fixation, staining) and biological heterogeneities (e.g., cell type, cell state) that are always present in a large cohort. On the other hand, perceptual interpretation/validation of important multivariate phenotypic signatures are often difficult due to the loss of visual information during feature transformation in hyperspace...
October 2016: Medical Image Computing and Computer-assisted Intervention: MICCAI ..
https://www.readbyqxmd.com/read/28018853/mri-flair-lesion-segmentation-in-multiple-sclerosis-does-automated-segmentation-hold-up-with-manual-annotation
#14
Christine Egger, Roland Opfer, Chenyu Wang, Timo Kepp, Maria Pia Sormani, Lothar Spies, Michael Barnett, Sven Schippling
INTRODUCTION: Magnetic resonance imaging (MRI) has become key in the diagnosis and disease monitoring of patients with multiple sclerosis (MS). Both, T2 lesion load and Gadolinium (Gd) enhancing T1 lesions represent important endpoints in MS clinical trials by serving as a surrogate of clinical disease activity. T2- and fluid-attenuated inversion recovery (FLAIR) lesion quantification - largely due to methodological constraints - is still being performed manually or in a semi-automated fashion, although strong efforts have been made to allow automated quantitative lesion segmentation...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28017890/rigidity-of-polymer-micelles-affects-interactions-with-tumor-cells
#15
Tal Stern, Inon Kaner, Neta Laser Zer, Hila Shoval, Dvir Dror, Zakhariya Manevitch, Liraz Chai, Yifat Brill-Karniely, Ofra Benny
Controlling the interaction of drug delivery systems (DDS) with tissues is critical for the success of therapies. Specifically in cancer, due to the high density of the tumors, tissue penetration of DDS is critical and may be challenging. In previous work we have shown that Solidified Polymer Micelles (SPMs) rapidly internalize into cells and tissues. Using AFM analysis, in the present work we measured differences in rigidity of SPM compared with Wet Polymer Micelles (WPM). We further examined whether the semi-solid form of hydrated SPMs has an effect on the interaction with tumor cells both in mono-layer systems and in multi-layer clusters of cells as spheroids...
December 23, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28002074/resolving-inflammation-by-using-nutrition-therapy-roles-for-specialized-proresolving-mediators
#16
Lucy V Norling, Lucy Ly, Jesmond Dalli
PURPOSE OF REVIEW: Inflammation is a unifying component of many of the diseases that afflict Western civilizations. Nutrition therapy and, in particular, essential fatty acid supplementation is one of the approaches that is currently in use for the treatment and management of many inflammatory conditions. The purpose of the present review is to discuss the recent literature in light of the discovery that essential fatty acids are converted by the body to a novel genus of lipid mediators, termed specialized proresolving mediators (SPMs)...
December 20, 2016: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/27997950/evaluating-treatment-and-generalization-patterns-of-two-theoretically-motivated-sentence-comprehension-therapies
#17
Carrie A Des Roches, Sofia Vallila-Rohter, Sarah Villard, Yorghos Tripodis, David Caplan, Swathi Kiran
Purpose: The current study examined treatment outcomes and generalization patterns following 2 sentence comprehension therapies: object manipulation (OM) and sentence-to-picture matching (SPM). Findings were interpreted within the framework of specific deficit and resource reduction accounts, which were extended in order to examine the nature of generalization following treatment of sentence comprehension deficits in aphasia. Method: Forty-eight individuals with aphasia were enrolled in 1 of 8 potential treatment assignments that varied by task (OM, SPM), complexity of trained sentences (complex, simple), and syntactic movement (noun phrase, wh-movement)...
December 1, 2016: American Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/27994579/intraclonal-genome-stability-of-the-metallo-%C3%AE-lactamase-spm-1-producing-pseudomonas-aeruginosa-st277-an-endemic-clone-disseminated-in-brazilian-hospitals
#18
Ana P B Nascimento, Mauro F Ortiz, Willames M B S Martins, Guilherme L Morais, Lorena C C Fehlberg, Luiz G P Almeida, Luciane P Ciapina, Ana C Gales, Ana T R Vasconcelos
Carbapenems represent the mainstay therapy for the treatment of serious P. aeruginosa infections. However, the emergence of carbapenem resistance has jeopardized the clinical use of this important class of compounds. The production of SPM-1 metallo-β-lactamase has been the most common mechanism of carbapenem resistance identified in P. aeruginosa isolated from Brazilian medical centers. Interestingly, a single SPM-1-producing P. aeruginosa clone belonging to the ST277 has been widely spread within the Brazilian territory...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27994534/influence-of-group-on-individual-subject-maps-in-spm-voxel-based-morphometry
#19
Andrew M Michael, Eli Evans, Gregory J Moore
Voxel based morphometry (VBM) is a widely utilized neuroimaging technique for spatially normalizing brain structural MRI (sMRI) onto a common template. The DARTEL technique of VBM takes into account the spatial intensity distribution of sMRIs to construct a study specific group template. The group template is then used to create final individual normalized tissue maps (FINTM) for each subject in the group. In this study, we investigate the effect of group on FINTM, i.e., we evaluate the variability of a constant subject's FINTM when other subjects in the group are iteratively changed...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27992543/meg-frequency-analysis-depicts-the-impaired-neurophysiological-condition-of-ischemic-brain
#20
Shinichi Sakamoto, Hidetoshi Ikeda, Naohiro Tsuyuguchi, Takehiro Uda, Eiichi Okumura, Takashi Asakawa, Yasuhiro Haruta, Hideki Nishiyama, Toyoji Okada, Hajime Kamada, Kenji Ohata, Yukio Miki
PURPOSE: Quantitative imaging of neuromagnetic fields based on automated region of interest (ROI) setting was analyzed to determine the characteristics of cerebral neural activity in ischemic areas. METHODS: Magnetoencephalography (MEG) was used to evaluate spontaneous neuromagnetic fields in the ischemic areas of 37 patients with unilateral internal carotid artery (ICA) occlusive disease. Voxel-based time-averaged intensity of slow waves was obtained in two frequency bands (0...
2016: PloS One
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