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https://www.readbyqxmd.com/read/29679953/antinociception-by-the-anti-oxidized-phospholipid-antibody-e06
#1
Milad Mohammadi, Beatrice Oehler, Jan Kloka, Corinna Martin, Alexander Brack, Robert Blum, Heike L Rittner
BACKGROUND AND PURPOSE: Reactive oxygen species (ROS) and their downstream molecules such as oxidized phospholipids (OxPL) and 4-hydroxynonenal (4-HNE) activate transient receptor potential ankyrin 1 (TRPA1) and vanilloid 1 (TRPV1) ion channels in vivo and in vitro shaping thermal and mechanical hypersensitivity in inflammatory pain. E06/T15 is a monoclonal autoantibody against oxidized phosphatidylcholine (OxPC) used in diagnostics in arteriosclerosis. Recently, we provided evidence that E06 also ameliorates inflammatory pain...
April 21, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29679946/extensive-depolarization-and-lack-of-recovery-of-leech-retzius-neurons-caused-by-2-4-diaminobutyric-acid
#2
S Spasic, M Stanojevic, J Nesovic Ostojic, S Kovacevic, M Prostran, S Lopicic
In this paper we present, for the first time, a detailed account of electrophysiological effects of 2,4-diaminobutyric acid (2,4-DABA). 2,4-DABA is a neurotoxic non-protein amino acid produced by Cyanobacteria with a possible link to neurodegenerative disorders in animals and humans. Intracellular recordings were performed on Retzius nerve cells of the leech Haemopis sanguisuga using glass microelectrodes filled with 3 mol/L KCl. Our results show that 2,4-DABA is an excitatory amino acid, causing membrane depolarization in a concentration-dependent manner...
March 31, 2018: Aquatic Toxicology
https://www.readbyqxmd.com/read/29679945/occurrence-elimination-enantiomeric-distribution-and-intra-day-variations-of-chiral-pharmaceuticals-in-major-wastewater-treatment-plants-in-beijing-china
#3
Lei Duan, Yizhe Zhang, Bin Wang, Shubo Deng, Jun Huang, Yujue Wang, Gang Yu
The occurrence, eliminations, enantiomeric distribution and intra-day variations of five chiral pharmaceuticals (three beta-blockers and two antidepressants) were investigated in eight major WWTPs in Beijing, China. The results revealed that metoprolol (MTP) and venlafaxine (VFX) were of the highest concentrations among the five determined pharmaceuticals with mean concentrations of 803 ng L-1 and 408 ng L-1 , respectively in influents, and 354 ng L-1 and 165 ng L-1 in effluents, respectively...
April 18, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29679943/photocatalytic-decomposition-of-selected-biologically-active-compounds-in-environmental-waters-using-tio-2-polyaniline-nanocomposites-kinetics-toxicity-and-intermediates-assessment
#4
Daniela V Šojić Merkulov, Vesna N Despotović, Nemanja D Banić, Sanja J Armaković, Nina L Finčur, Marina J Lazarević, Dragana D Četojević-Simin, Dejan Z Orčić, Marija B Radoičić, Zoran V Šaponjić, Mirjana I Čomor, Biljana F Abramović
A comprehensive study of the removal of selected biologically active compounds (pharmaceuticals and pesticides) from different water types was conducted using bare TiO2 nanoparticles and TiO2 /polyaniline (TP-50, TP-100, and TP-150) nanocomposite powders. In order to investigate how molecular structure of the substrate influences the rate of its removal, we compared degradation efficiency of the initial substrates and degree of mineralization for the active components of pharmaceuticals (propranolol, and amitriptyline) and pesticides (sulcotrione, and clomazone) in double distilled (DDW) and environmental waters...
April 18, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29679935/the-role-of-adsorbate-size-on-adsorption-of-ne-and-xe-on-graphite
#5
Luisa Prasetyo, Quang K Loi, Shiliang Johnathan Tan, D D Do, D Nicholson
We have carried out an extensive grand canonical Monte Carlo simulation to investigate the adsorption of neon and xenon on graphite. The adsorbate collision diameters of neon and xenon are smaller and greater respectively, than the commensurate graphite lattice spacing λ=3×3R300 of 0.426 nm. Simulated isotherms and isosteric heats were obtained using a graphite model that has been shown to describe successfully the adsorbate transitions for krypton, methane and nitrogen by Prasetyo et al. (2017), which have collision diameters close to λ...
April 10, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29679927/excitation-functions-of-proton-and-deuteron-induced-nuclear-reactions-on-natural-iridium-for-the-production-of-191-pt
#6
Honoka Obata, Mayeen Uddin Khandaker, Etsuko Furuta, Kotaro Nagatsu, Ming-Rong Zhang
We studied the excitation functions of residual radionuclides produced via proton and deuteron bombardment on natural iridium in the energy ranges of 30-15 MeV and 50-15 MeV, respectively. A conventional stacked-foil activation technique combined with HPGe γ-ray spectrometry was used to measure the excitation functions for 189, 191 Pt and 189, 190g, 192g, 194g Ir radionuclide production. Theoretical thick target yields were estimated to be 172 MBq/µA h and 192 MBq/µA h via the 193 Ir(p,3n)191 Pt reaction at 29...
March 30, 2018: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/29679913/the-relation-between-gray-matter-volume-and-the-use-of-alcohol-tobacco-cocaine-and-cannabis-in-male-polysubstance-users
#7
A M Kaag, M H J Schulte, J M Jansen, G van Wingen, J Homberg, W van den Brink, R W Wiers, L Schmaal, A E Goudriaan, L Reneman
BACKGROUND: Neuroimaging studies have demonstrated gray matter (GM) volume abnormalities in substance users. While the majority of substance users are polysubstance users, very little is known about the relation between GM volume abnormalities and polysubstance use. METHODS: In this study we assessed the relation between GM volume, and the use of alcohol, tobacco, cocaine and cannabis as well as the total number of substances used, in a sample of 169 males: 15 non-substance users, 89 moderate drinkers, 27 moderate drinkers who also smoke tobacco, 13 moderate drinkers who also smoke tobacco and use cocaine, 10 heavy drinkers who smoke tobacco and use cocaine and 15 heavy drinkers who smoke tobacco, cannabis and use cocaine...
April 15, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29679905/qing-brick-tea-qbt-aqueous-extract-protects-monosodium-glutamate-induced-obese-mice-against-metabolic-syndrome-and-involves-up-regulation-transcription-factor-nuclear-factor-erythroid-2-related-factor-2-nrf2-antioxidant-pathway
#8
Wenqi Gao, Changyi Xiao, Jun Hu, Biaoxin Chen, Chunyan Wang, Bangping Cui, Pengyi Deng, Jian Yang, Zhifang Deng
BACKGROUND: Qing brick tea (QBT), traditional and popular beverage for Chinese people, is an important post-fermentation dark tea. Our present study was performed to investigate the ameliorative effects of QBT aqueous extract on metabolic syndrome (Mets) in monosodium glutamate-induced obese mice and the potential mechanisms. METHOD: Monosodium glutamate-induced obese mice were used to evaluate the anti-Mets effects of QBT. Content levels of malonaldehyde (MDA), reactive oxygen species (ROS) and protein carbonylation, antioxidant enzyme activities of superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT), glutathione reductase (GR) in the skeletal muscle were assessed by commercial kits, respectively...
April 18, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29679903/isoharringtonine-inhibits-breast-cancer-stem-like-properties-and-stat3-signaling
#9
Wei Chen, Hui Wang, Mei Cheng, Ling Ni, Li Zou, Qin Yang, Xianghai Cai, Baowei Jiao
OBJECTIVES: Breast cancer stem cells (BCSCs) contribute to breast cancer progression, relapse, and treatment resistance. Identification of the natural inhibitory components of BCSCs is therefore critical for clinical treatment. Here, we investigated whether isoharringtonine (IHT) had inhibitory effects on BCSCs in breast cancer cell lines. METHODS: HCC1806, HCC1937, and MCF7 cells were treated with IHT. The proliferation and the migration of cells were detected by MTS assay and wound healing migration assay, respectively...
April 18, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29679900/structural-insights-into-serotonin-receptor-ligands-polypharmacology
#10
Sabina Podlewska, Rafał Kafel, Enza Lacivita, Grzegorz Satała, Albert J Kooistra, Márton Vass, Chris de Graaf, Marcello Leopoldo, Andrzej J Bojarski, Stefan Mordalski
Identifying desired interactions with a target receptor is often the first step when designing new active compounds. However, attention should also be focused on contacts with other proteins that result in either selective or polypharmacological compounds. Here, the search for the structural determinants of selectivity between selected serotonin receptor subtypes was carried out. Special attention was focused on 5-HT7 R and the cross-interactions between its ligands and the 5-HT1A R, 5-HT1B R, 5-HT2A R, 5-HT2B R, and 5-HT6 R subtypes...
April 6, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29679896/treatment-as-usual-tau-as-a-control-condition-in-trials-of-cognitive-behavioural-based-psychotherapy-for-self-harm-impact-of-content-and-quality-on-outcomes-in-a-systematic-review
#11
REVIEW
Katrina Witt, Daniela Pache de Moraes, Tatiana Taylor Salisbury, Ella Aren S Man, David Gunnell, Philip Hazell, Ellen Townsend, Kees van Heeringen, Keith Hawton
BACKGROUND: Randomized controlled trials (RCTs) are the mainstay of evaluations of the efficacy of psychosocial interventions. In a recent Cochrane systematic review we analysed the efficacy of cognitive behavioural-based psychotherapies compared to treatment as usual (TAU) in adults who self-harm. In this study we examine the content and reporting quality of TAU in these trials and their relationship to outcomes. METHODS: Five electronic databases (CCDANCTR-Studies and References, CENTRAL, MEDLINE, EMBASE, and PsycINFO) were searched for RCTs, indexed between 1 January 1998 and 30 April 2015, of cognitive-behavioural interventions compared to TAU for adults following a recent (within six months) episode of self-harm...
April 4, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29679887/determining-chewing-efficiency-using-a-solid-test-food-and-considering-all-phases-of-mastication
#12
Ting Liu, Xinmiao Wang, Jianshe Chen, Hilbert W van der Glas
OBJECTIVES: Following chewing a solid food, the median particle size, X50 , is determined after N chewing cycles, by curve-fitting of the particle size distribution. Reduction of X50 with N is traditionally followed from N ≥ 15-20 cycles when using the artificial test food Optosil® , because of initially unreliable values of X50 . The aims of the study were (i) to enable testing at small N-values by using initial particles of appropriate size, shape and amount, and (ii) to compare measures of chewing ability, i...
April 10, 2018: Archives of Oral Biology
https://www.readbyqxmd.com/read/29679881/ventrolateral-orbital-cortex-oxytocin-attenuates-neuropathic-pain-through-periaqueductal-gray-opioid-receptor
#13
Mina Taati, Esmaeal Tamaddonfard
BACKGROUND: Oxytocin plays an important role in supraspinal modulation of pain. In the present study, we investigated the effects of ventrolateral orbital cortex (VLOC) microinjection of oxytocin on neuropathic pain after blockade of opioid receptors in this area and ventrolateral periaqueductal gray (vlPAG). METHODS: Neuropathic pain was induced by complete transcection of preoneal and tibial branches of sciatic nerve. The VLOC and vlPAG were unilaterally (contralateral to the sciatic nerve-injured side) and bilaterally implanted with guide cannulas, respectively...
December 21, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29679868/impact-of-hydrochar-on-rice-paddy-ch-4-and-n-2-o-emissions-a-comparative-study-with-pyrochar
#14
Beibei Zhou, Yanfang Feng, Yueman Wang, Linzhang Yang, Lihong Xue, Baoshan Xing
Hydrothermal carbonization (HTC) thermally converts wet biomasses to carbon materials, dramatically reducing energy use for drying and improving solid product yield compared to pyrolysis process. However, researches regarding agricultural usage of hydrochar (HC) are limited. In the present study, the influence of HC amendment on CH4 and N2 O emissions, as well as global warming potential (GWP) and greenhouse gas intensity (GHGI) were investigated. Additionally, pyrochar (PC) treatments as well as two char-free control treatments with (CKU) or without (CK) N fertilizer were also included for comparison...
April 12, 2018: Chemosphere
https://www.readbyqxmd.com/read/29679866/influence-of-humic-substances-on-iron-distribution-in-the-east-china-sea
#15
Han Su, Rujun Yang, Yan Li, Xuchen Wang
The influence of humic substances (specifically humic and fulvic acids, referred to as HS-HA and HS-FA) as well as other factors, such as major nutrient concentrations of total dissolved nitrogen (TDN), total dissolved phosphate (TDP) and hydrologic factors, on the distribution of total dissolved iron (DFe) and the chemical speciation of DFe was studied in the East China Sea (ECS) during a summer cruise in 2013. As the wide rage fraction of nature organic matter, the HS-HA, HS-FA in ESC contains most part of the organic ligand (Lt) of DFe...
April 9, 2018: Chemosphere
https://www.readbyqxmd.com/read/29679864/computational-insights-into-%C3%AE-site-amyloid-precursor-protein-enzyme-1-bace1-inhibition-by-tanshinones-and-salvianolic-acids-from-salvia-miltiorrhiza-via-molecular-docking-simulations
#16
Ting Yu, Pradeep Paudel, Su Hui Seong, Jeong Ah Kim, Hyun Ah Jung, Jae Sue Choi
The rhizome of Salvia miltiorrhiza has emerged as a rich source of natural therapeutic agents, and its several compounds are supposed to exhibit favorable effects on Alzheimer's disease (AD). The present work investigate the anti-AD potentials of 12 tanshinones, three salvianolic acids and three caffeic acid derivatives from S. miltiorrhiza via the inhibition of β-site amyloid precursor protein cleaving enzyme 1 (BACE1). Among the tested compounds, deoxyneocryptotanshinone (1), salvianolic acid A (13) and salvianolic acid C (15) displayed good inhibitory effect on BACE1 with IC50 values of 11...
April 13, 2018: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/29679858/anti-inflammatory-effect-of-apo-9-fucoxanthinone-via-inhibition-of-mapks-and-nf-kb-signaling-pathway-in-lps-stimulated-raw-264-7-macrophages-and-zebrafish-model
#17
Eun-A Kim, Seo-Young Kim, Bo-Ram Ye, Junseong Kim, Seok-Chun Ko, Won Woo Lee, Kil-Nam Kim, Il-Whan Choi, Won-Kyo Jung, Soo-Jin Heo
In this study, we confirmed the anti-inflammatory effect of Apo-9-fucoxanthinone (AF) in in vitro RAW 264.7 cells and in vivo zebrafish model. In lipopolysaccharide (LPS)-stimulated zebrafish, AF significantly decreased the production of reactive oxygen species (ROS), nitric oxide (NO) and cell death. In addition, the mRNA expression of inducible nitric oxide synthase (iNOS), suppressed cyclooxygenase-2 (COX-2) and an inflammatory cytokines; IL-1β, TNF-α were shown reduction. And AF significantly inhibited NO production and expression of iNOS in LPS-stimulated RAW 264...
April 18, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29679852/accident-analysis-to-support-the-development-of-strategies-for-the-prevention-of-brain-injuries-in-car-crashes
#18
Jacobo Antona-Makoshi, Koji Mikami, Mats Lindkvist, Johan Davidsson, Sylvia Schick
This study estimated the frequency and risk of Moderate-to-Maximal traumatic brain injuries sustained by occupants in motor vehicle crashes in the US. National Automotive Sampling System - Crashworthiness Data System crashes that occurred in years 2001-2015 with light vehicles produced 2001 or later were incorporated in the study. Crash type, crash severity, car model year, belt usage and occupant age and sex were controlled for in the analysis. The results showed that Moderate concussions account for 79% of all MAISbrain 2+ injuries...
April 18, 2018: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/29679846/biodegradability-and-ecological-safety-assessment-of-stenotrophomonas-sp-ddt-1-in-the-ddt-contaminated-soil
#19
Hua Fang, Yanfei Deng, Qiqing Ge, Jiajia Mei, Houpu Zhang, Huifang Wang, Yunlong Yu
The biodegradability and ecological safety assessment of the previously isolated DDT-degrading bacterial strain Stenotrophomonas sp. DDT-1 were investigated in the DDT-contaminated soil under laboratory and field conditions. Under laboratory conditions, the degradation rates of fresh p,p'-DDT in soil were enhanced by 2.0-3.0-fold with the introduction of the strain DDT-1 compared to those of the control treatments. A similar enhancement in the dissipation of DDTs (p,p'-DDT, p,p'-DDE, p,p'-DDD, and o,p'-DDT) in the aged DDT-contaminated field plot soils resulted from the inoculation with this strain...
April 18, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29679833/the-contribution-of-cattle-urine-and-dung-to-nitrous-oxide-emissions-quantification-of-country-specific-emission-factors-and-implications-for-national-inventories
#20
D R Chadwick, L M Cardenas, M S Dhanoa, N Donovan, T Misselbrook, J R Williams, R E Thorman, K L McGeough, C J Watson, M Bell, S G Anthony, R M Rees
Urine patches and dung pats from grazing livestock create hotspots for production and emission of the greenhouse gas, nitrous oxide (N2 O), and represent a large proportion of total N2 O emissions in many national agricultural greenhouse gas inventories. As such, there is much interest in developing country specific N2 O emission factors (EFs) for excretal nitrogen (EF3, pasture, range and paddock) deposited during gazing. The aims of this study were to generate separate N2 O emissions data for cattle derived urine and dung, to provide an evidence base for the generation of a country specific EF for the UK from this nitrogen source...
April 18, 2018: Science of the Total Environment
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