Timothy Arthur Chandos Snow, Alessia V Waller, Richard Loye, Francis Ryckaert, Antonio Cesar, Naveed Saleem, Rudra Roy, John Whittle, Ahmed Al-Hindawi, Abhishek Das, Mervyn Singer, David Brealey, Nishkantha Arulkumaran
BACKGROUND: Post-operative infections are a common cause of morbidity following major surgery. Little is understood about how major surgery perturbs immune function leading to heightened risk of subsequent infection. Through analysis of paired blood samples obtained immediately before and 24 h following surgery, we evaluated changes in circulating immune cell phenotype and function across the first 24 h, to identify early immune changes associated with subsequent infection. METHODS: We conducted a prospective observational study of adult patients undergoing major elective gastrointestinal, gynecological, or maxillofacial surgery requiring planned admission to the post-anesthetic care unit...
2024: Frontiers in Immunology