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https://www.readbyqxmd.com/read/29928971/the-venom-of-spider-haplopelma-hainanum-suppresses-proliferation-and-induces-apoptosis-in-hepatic-cancer-cells-by-caspase-activation-in-vitro
#1
Weiguang Lian, Hongguang Lian, Qian Li, Hu An, Shufeng Liu
ETHNOPHARMACOLOGICAL RELEVANCE: Spiders and spider venoms have been used in traditional Chinese medicine to treat various ailments for more than 1,000 years. For instance, several large spiders have been utilized by the Li People, who mainly live in Hainan Island of China, in their own unique traditional Chinese medicine therapy. Recent studies have indicated that spider venoms may be an important source of bioactive compounds for anti-tumor treatments. However, the specific mechanisms underlying these activities are not yet completely understood...
June 18, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29927720/improving-family-medicine-resident-training-in-dementia-care-an-experiential-learning-opportunity-in-primary-care-collaborative-memory-clinics
#2
Linda Lee, W Wayne Weston, Loretta Hillier, Douglas Archibald, Joseph Lee
Family physicians often find themselves inadequately prepared to manage dementia. This article describes the curriculum for a resident training intervention in Primary Care Collaborative Memory Clinics (PCCMC), outlines its underlying educational principles, and examines its impact on residents' ability to provide dementia care. PCCMCs are family physician-led interprofessional clinic teams that provide evidence-informed comprehensive assessment and management of memory concerns. Within PCCMCs residents learn to apply a structured approach to assessment, diagnosis, and management; training consists of a tutorial covering various topics related to dementia followed by work-based learning within the clinic...
June 21, 2018: Gerontology & Geriatrics Education
https://www.readbyqxmd.com/read/29925407/astonishing-diversity-the-medicinal-plant-markets-of-bogot%C3%A3-colombia
#3
Rainer W Bussmann, Narel Y Paniagua Zambrana, Carolina Romero, Robbie E Hart
BACKGROUND: Despite the importance of local markets as a source of medicinal plants in Colombia, comparatively little comparative research reports on the pharmacopoeiae sold. This stands in contrast to wealth of available information for other components of plant use in Colombia and other countries. The present provides a detailed inventory of the medicinal plant markets in the Bogotá metropolitan area, hypothesizing that the species composition, and medicinal applications, would differ across markets of the city...
June 20, 2018: Journal of Ethnobiology and Ethnomedicine
https://www.readbyqxmd.com/read/29924966/a-proteomic-variant-approach-provara-for-personalized-medicine-of-inherited-and-somatic-disease
#4
DarrenM Hutt, Salvatore Loguercio, Alexandre Rosa Campos, William E Balch
The advent of precision medicine for genetic diseases has been hampered by the large number of variants that cause familial and somatic disease, a complexity that is further confounded by the impact of genetic modifiers. To begin to understand differences in onset, progression and therapeutic response that exist among disease-causing variants, we present the proteomic variant approach (ProVarA), a proteomic method that integrates mass spectrometry with genomic tools to dissect the etiology of disease. To illustrate its value, we examined the impact of variation in cystic fibrosis (CF), where 2025 disease-associated mutations in the CF transmembrane conductance regulator (CFTR) gene have been annotated and where individual genotypes exhibit phenotypic heterogeneity and response to therapeutic intervention...
June 17, 2018: Journal of Molecular Biology
https://www.readbyqxmd.com/read/29924763/dental-status-salivary-flow-and-sociodemographic-aspects-in-sheehan-syndrome-patients
#5
D-D-S Cavalcante, A-R Pinto-Quidute, M-R Alves-Martins, A-S Walter-de-Aguiar, A-M-P Lima-Cid, P-G-B Silva, R-F Cavalcante, F-W-G Costa
BACKGROUND: Sheehan's syndrome (SS) is one of the leading causes of hypopituitarism in developing countries. It occurs after postpartum necrosis of the pituitary gland, and it is considered a significant public health problem. This paper, apparently unpublished, aimed to perform an analysis on oral aspects in patients with SS. MATERIAL AND METHODS: A cross-sectional study was performed with 23 women diagnosed with SS at the Division of Endocrinology and Diabetes (Walter Cantídio University Hospital, Fortaleza, Brazil)...
June 20, 2018: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/29923222/effects-of-curcumin-on-nf-%C3%AE%C2%BAb-ap-1-and-wnt-%C3%AE-catenin-signaling-pathway-in-hepatitis-b-virus-infection
#6
AmirReza Hesari, Faezeh Ghasemi, Reza Salarinia, Hamed Biglari, Agheel Tabar Molla Hassan, Vali Abdoli, Hamed Mirzaei
Curcumin is a yellow-orange powder derived from the Curcuma longa plant. Curcumin has been used extensively in traditional medicine for centuries. This component is non-toxic and shown different therapeutic properties such as anti-inflammatory, anti-cancer, antiviral, anti-bacterial, anti-fungal, anti-parasites, and anti-oxidant. Hepatitis B virus (HBV) is a small DNA member of the genus Orthohepadnavirus (Hepadnaviridae family) which is a highly contagious blood-borne viral pathogen. HBV infection is a major public health problem with 2 billion people infected throughout the world and 350 million suffering from chronic HBV infection...
June 19, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29922910/-prescribing-valproate-to-girls-and-women-of-childbearing-age-in-germany-analysis-of-trends-based-on-claims-data
#7
Nadine Wentzell, Ulrike Haug, Tania Schink, Susanne Engel, Judith Liebentraut, Roland Linder, Marlies Onken, Christof Schaefer, Katarina Dathe
BACKGROUND: Measures to raise awareness of the teratogenic potential of valproate and restrict its use in girls/women of childbearing age have been intensified. For Germany, the impact of these measures on valproate prescription rates remains unknown. OBJECTIVES: Trends in prescribing valproate, the underlying treatment indication, and the specialty of the prescribing physician are analyzed. MATERIALS AND METHODS: With claims data from several statutory health insurance providers from 2004 to 2016 (approximately 3...
June 19, 2018: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/29922065/current-treatment-options-for-psoriatic-arthritis-spotlight-on-abatacept
#8
REVIEW
Francesco Ursini, Emilio Russo, Roberto De Giorgio, Giovambattista De Sarro, Salvatore D'Angelo
Psoriatic arthritis (PsA) is a chronic inflammatory disease of joints, tendon sheaths, and entheses affecting patients with established skin psoriasis, or, less frequently, patients without a personal history of psoriasis with a positive familial history. Many treatment options are now available to deal with the different aspects of the disease, including traditional and biological disease-modifying antirheumatic drugs and the recently released targeted synthetic disease-modifying antirheumatic drugs. However, ~40% of patients still fail to achieve a meaningful clinical response to first-line biologic therapy advocating the development of novel medications...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29921193/potential-application-of-venom-proteins-in-designing-of-medicines-for-treating-human-neurodegenerative-disorders
#9
Zahid Rasul Niazi, Naqab Khan, Samiullah Khan, Mehboob Alam, Mohammad A Kamal
BACKGROUND: Neurodegenerative disorder are persistently increasing and relentlessly affecting the individuals, families and society as whole. Regrettably these disorders are resistant to the available drugs, the outcomes are only palliative while the side effects of the therapy harm the patient compliance as well as treatment. Drugs from venomous source have been considered as an effective alternative for such types of disorders, particularly neurodegenerative diseases. Due to emerging advancement in the field of proteomics, genomics and molecular biology, characterization and screening of these novel compounds become more assessable...
June 14, 2018: Protein and Peptide Letters
https://www.readbyqxmd.com/read/29921179/-promising-future-in-general-internal-medicine-for-the-next-generation-of-physicians
#10
Victoria Perpinias Allenbach, Zsofia Rozsnyai, Sven Streit
Promising Future in General Internal Medicine for the Next Generation of Physicians Abstract. We are facing a lack of specialists in general internal medicine in general practitioners' practices as well as in hospitals, while at the same time the population ages and usually displays several chronic diseases (multimorbidity). Thanks to more university places, an improved job description for general internal medicine and new further education offers (curricula), interest in general internal medicine increased again, as surveys of students indicate...
June 2018: Praxis
https://www.readbyqxmd.com/read/29920838/hours-worked-by-general-practitioners-and-waiting-times-for-primary-care
#11
Megha Swami, Hugh Gravelle, Anthony Scott, Jenny Williams
The decline in the working hours of general practitioners (GPs) is a key factor influencing access to health care in many countries. We investigate the effect of changes in hours worked by GPs on waiting times in primary care using the Medicine in Australia: Balancing Employment and Life longitudinal survey of Australian doctors. We estimate GP fixed effects models for waiting time and use family circumstances to instrument for GP's hours worked. We find that a 10% reduction in hours worked increases average patient waiting time by 12%...
June 19, 2018: Health Economics
https://www.readbyqxmd.com/read/29920822/a-scoping-review-of-the-pharmaceutical-care-needs-of-people-with-sensory-loss
#12
REVIEW
Kirsty Killick, Leah Macaden, Annetta Smith, Thilo Kroll, Kathleen Stoddart, Margaret C Watson
OBJECTIVES: This scoping review collated evidence of the pharmaceutical care needs of people with sensory loss (SL). METHODS: Electronic databases were searched with no limit on year of publication: Medline (1946); Embase; Cinahl (1979); and Web of Science (1985). Search terms included the following: pharmacy; sight/hearing/dual impairment. Studies were included if they involved people with SL requiring pharmaceutical care and/or pharmacists/pharmacy support staff providing pharmaceutical care for people with SL...
June 19, 2018: International Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/29916432/approach-to-family-assessment-and-intervention
#13
Anand Krishnan, Priyamadhaba Behera, Baridalyne Nongkynrih
Background.: Family studies are an integral part of teaching of community medicine to all undergraduate medical and nursing students. It enhances the understanding of students about social determinants and multifactorial causation of disease. However, there is no standard approach towards it and it is seen as a clinical presentation with some elements of family included. We describe a systematic and comprehensive approach to a family study. Methods.: Based on the existing literature and personal experience, we identified 11 domains under the acronym Family ASSESSMENT-Structure, Socioeconomic, Sickness, Nutritional, Educational, Environmental, Affordability, System (health), Mental, Family influence, Threats...
September 2017: National Medical Journal of India
https://www.readbyqxmd.com/read/29915760/family-medicine-perception-and-attitudes-among-indian-medical-students
#14
Ilhaam Ashraf, Wendy W T Chan, Ramakrishna Prasad, Mohan Kubendra, D Hemavathy, Shailendra Prasad
Context: Currently, family medicine is not taught as a part of the undergraduate medical curriculum in India. In this context, the perceptions and attitudes of Indian medical students regarding family medicine as a career choice were studied. Aims: This study aims to study the perceptions and attitudes prevalent among Indian medical students regarding family medicine as a career choice and discuss its future implications. Settings and Design: Cross-sectional survey study design...
January 2018: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29915734/proficiency-testing-for-admission-to-the-postgraduate-family-medicine-education
#15
Birgitte Schoenmakers, Johan Wens
Theory: In Belgium, there are no family medicine admission requirements. A three-phase admission program is developed and implemented by the collaboration of four involved universities. Hypotheses: A pilot testing of phase 2, comprising actual proficiency test, is designed as answer to two research questions: What is the validity and reliability of a multicomponent proficiency test? How does a multicomponent proficiency test proportionate to the final grades of family medicine master candidates? Methods: The population consisted of all last master-phase students applying for family medicine education in Flanders...
January 2018: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29914858/telemedicine-use-among-caregivers-of-cancer-patients-systematic-review
#16
REVIEW
Chiara Marzorati, Chiara Renzi, Samuel William Russell-Edu, Gabriella Pravettoni
BACKGROUND: The number of published studies and systematic reviews examining different telehealth interventions targeting patients and their effects on patients' well-being and quality of life have grown in recent decades. However, the use of telemedicine tools aimed at the family members and caregivers of adult cancer patients is less defined. OBJECTIVE: We aimed to conduct a systematic review to provide a more complete picture regarding telemedicine tools for informal caregivers (usually family members or close friends) implemented in all phases of cancer care...
June 18, 2018: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29914755/transition-from-pediatric-to-adult-care-in-adolescents-with-hereditary-metabolic-diseases-specific-guidelines-from-the-french-network-for-rare-inherited-metabolic-diseases-g2m
#17
B Chabrol, P Jacquin, L Francois, P Broué, D Dobbelaere, C Douillard, S Dubois, F Feillet, A Perrier, A Fouilhoux, F Labarthe, D Lamireau, K Mazodier, F Maillot, F Mochel, M Schiff, N Belmatoug
Inherited metabolic diseases (IMD) form a heterogeneous group of genetic disorders that surface primarily during childhood and result in significant morbidity and mortality. A prevalence of 1 in 2500-5000 live births is often reported. The transfer of adolescents from pediatric care to adult health facilities is often difficult for patients and their families and can lead to a breakdown in medical follow-up and therefore serious complications. Existing recommendations for the successful transition of patients with chronic disorders do not specifically address patients with IMDs associated with dietary treatment...
June 15, 2018: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/29914489/characterization-of-the-biosynthetic-gene-cluster-of-the-polyene-macrolide-antibiotic-reedsmycins-from-a-marine-derived-streptomyces-strain
#18
Tingting Yao, Zengzhi Liu, Tong Li, Hui Zhang, Jing Liu, Huayue Li, Qian Che, Tianjiao Zhu, Dehai Li, Wenli Li
BACKGROUND: Polyene antibiotics are important as antifungal medicines albeit with serious side effects such as nephrotoxicity. Reedsmycin (RDM) A (1), produced by marine-derived Streptomyces youssoufiensis OUC6819, is a non-glycosylated polyene macrolide antibiotic with antifungal activity comparable to that of clinically used nystatin. To elucidate its biosynthetic machinery, herein, the rdm biosynthetic gene cluster was cloned and characterized. RESULTS: The rdm cluster is located within a 104 kb DNA region harboring 21 open reading frames (ORFs), among which 15 ORFs were designated as rdm genes...
June 19, 2018: Microbial Cell Factories
https://www.readbyqxmd.com/read/29914462/factors-associated-with-motivation-in-medical-education-a-path-analysis
#19
Natchaya Kunanitthaworn, Tinakon Wongpakaran, Nahathai Wongpakaran, Salilthip Paiboonsithiwong, Natchaphon Songtrijuck, Pimolpun Kuntawong, Danny Wedding
BACKGROUND: This study identified and investigated the relationship between demographics, mental health problems, positive personality traits and perceived social support and motivation in medical education (MME) among first year medical students. METHODS: One hundred-thirty eight first year medical students completed the Academic Motivation Scale, Outcome Inventory, Strength Based Inventory, and Multidimensional Scale for Perceived Social Support. Path analysis was conducted to identify relationships between the variables of interest and each type of motivation, including intrinsic and extrinsic motivation and amotivation...
June 18, 2018: BMC Medical Education
https://www.readbyqxmd.com/read/29914459/ethical-concerns-on-sharing-genomic-data-including-patients-family-members
#20
Kyoko Takashima, Yuichi Maru, Seiichi Mori, Hiroyuki Mano, Tetsuo Noda, Kaori Muto
BACKGROUND: Platforms for sharing genomic and phenotype data have been developed to promote genomic research, while maximizing the utility of existing datasets and minimizing the burden on participants. The value of genomic analysis of trios or family members has increased, especially in rare diseases and cancers. This article aims to argue the necessity of protection when sharing data from both patients and family members. MAIN TEXT: Sharing patients' and family members' data collectively raises an ethical tension between the value of datasets and the rights of participants, and increases the risk of re-identification...
June 18, 2018: BMC Medical Ethics
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