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https://www.readbyqxmd.com/read/28975714/comparing-the-performance-of-three-panels-rules-of-blood-smear-review-criteria-on-an-italian-multicenter-evaluation
#1
S Pipitone, L Germagnoli, G Da Rin, A Di Fabio, A Fanelli, F Fiorini, S Francione, A Marini, A Papa, A Benegiamo, T Lari, F Siviero, M Lorubbio, M Borin, M Seghezzi, M L Ciardelli, F Dima, M Gioia, S Buoro
BACKGROUND: The aims of this study were to compare the diagnostic accuracy of blood smear review criteria, by means of three different panel rules, those proposed by: the International Consensus Group for Hematology [41-ICGH rules], the Italian Survey [IS rules] and the Working Group on Hematology-SIBioC (WGH) consensus rules (WGH rules). METHODS: This study is based on 2707 peripheral blood (PB) samples referred for routine hematological testing to the WGH-associated laboratories displaced all over the Italian territory...
October 3, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28874832/antibiotic-induced-perturbations-in-microbial-diversity-during-post-natal-development-alters-amyloid-pathology-in-an-aged-appswe-ps1%C3%AE-e9-murine-model-of-alzheimer-s-disease
#2
Myles R Minter, Reinhard Hinterleitner, Marlies Meisel, Can Zhang, Vanessa Leone, Xiaoqiong Zhang, Paul Oyler-Castrillo, Xulun Zhang, Mark W Musch, Xunuo Shen, Bana Jabri, Eugene B Chang, Rudolph E Tanzi, Sangram S Sisodia
Recent evidence suggests the commensal microbiome regulates host immunity and influences brain function; findings that have ramifications for neurodegenerative diseases. In the context of Alzheimer's disease (AD), we previously reported that perturbations in microbial diversity induced by life-long combinatorial antibiotic (ABX) selection pressure in the APPSWE/PS1ΔE9 mouse model of amyloidosis is commensurate with reductions in amyloid-β (Aβ) plaque pathology and plaque-localised gliosis. Considering microbiota-host interactions, specifically during early post-natal development, are critical for immune- and neuro-development we now examine the impact of microbial community perturbations induced by acute ABX exposure exclusively during this period in APPSWE/PS1ΔE9 mice...
September 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28856214/the-roche-total-mycophenolic-acid%C3%A2-assay-an-application-protocol-for-the-abx-pentra-400-analyzer-and-comparison-with-lc-ms-in-children-with-idiopathic-nephrotic-syndrome
#3
François Parant, Bruno Ranchin, Marie-Claude Gagnieu
BACKGROUND: For TDM of mycophenolate acid (MPA), the Roche Total Mycophenolic Acid® assay based on the inhibition of recombinant inosine monophosphate dehydrogenase (IMPDH) has been shown to be a simple and reliable alternative to chromatographic methods. We have adapted this assay on the ABX Pentra 400 analyzer (HORIBA). OBJECTIVE: To investigate the analytical performances of the Roche Total Mycophenolic Acid® assay on the ABX Pentra 400 and to compare it to an LC-MS method using samples from children with nephrotic syndrome treated with mycophenolate mofetil (MMF)...
April 2017: Pract Lab Med
https://www.readbyqxmd.com/read/28711154/western-diet-induced-dysbiosis-in-farnesoid-x-receptor-knockout-mice-causes-persistent-hepatic-inflammation-after-antibiotic-treatment
#4
Prasant K Jena, Lili Sheng, Hui-Xin Liu, Karen M Kalanetra, Annie Mirsoian, William J Murphy, Samuel W French, Viswanathan V Krishnan, David A Mills, Yu-Jui Yvonne Wan
Patients who have liver cirrhosis and liver cancer also have reduced farnesoid X receptor (FXR). The current study analyzes the effect of diet through microbiota that affect hepatic inflammation in FXR knockout (KO) mice. Wild-type and FXR KO mice were on a control (CD) or Western diet (WD) for 10 months. In addition, both CD- and WD-fed FXR KO male mice, which had hepatic lymphocyte and neutrophil infiltration, were treated by vancomycin, polymyxin B, and Abx (ampicillin, neomycin, metronidazole, and vancomycin)...
August 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28691426/physical-activity-related-changes-in-adma-and-vwf-levels-in-patients-with-type-2-diabetes-a-preliminary-study
#5
Zanna Fiodorenko-Dumas, Ilias Dumas, Krzysztof Mastej, Rajmund Adamiec
BACKGROUND: The activity and the role of methylarginine in diabetic patients are subject to continuous research. The mechanism through which diabetes or insulin resistance increases asymmetric dimethylarginine (ADMA) serum levels is not fully understood.Studies indicate increased ADMA serum levels in patients with hypertension, hypercholesterolemia and hyperhomocysteinemia. OBJECTIVES: The aim of the study was to assess changes in the levels of ADMA and its derivatives related to the current disease process, as well as the levels of selected prothrombotic factors and their changes induced by physical activity...
June 27, 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28680633/therapeutic-drug-monitoring-for-colistin-therapy-in-severe-multi-resistant-acinetobacter-intracerebral-abscess-a-single-case-study-with-high-dose-colistin-and-review-of-literature
#6
Sascha Tafelski, Lukas Wagner, Stefan Angermair, Maria Deja
OBJECTIVES: Intracranial infections due to multidrug- resistant (MDR) gram-negative pathogens are associated with increased morbidity and mortality. As therapeutic options are limited and systemic drug penetration into the infection focus is difficult, intraventricular therapy has been described. METHODS: We report on a patient with intracranial abscess caused by MDR Acinetobacter baumannii. RESULTS: He was treated with high doses of intravenous and intraventricular colistin resulting in microbiological clearance and clinical cure...
2017: SAGE open medical case reports
https://www.readbyqxmd.com/read/28660660/photovoltaic-rudorffites-lead-free-silver-bismuth-halides-alternative-to-hybrid-lead-halide-perovskites
#7
Ivan Turkevych, Said Kazaoui, Eisuke Ito, Toshiyuki Urano, Koji Yamada, Hiroshi Tomiyasu, Hideo Yamagishi, Michio Kondo, Shinji Aramaki
Hybrid CPbX3 (C: Cs, CH3 NH3 ; X: Br, I) perovskites possess excellent photovoltaic properties but are highly toxic, which hinders their practical application. Unfortunately, all Pb-free alternatives based on Sn and Ge are extremely unstable. Although stable and non-toxic C2 ABX6 double perovskites based on alternating corner-shared AX6 and BX6 octahedra (A=Ag, Cu; B=Bi, Sb) are possible, they have indirect and wide band gaps of over 2 eV. However, is it necessary to keep the corner-shared perovskite structure to retain good photovoltaic properties? Here, we demonstrate another family of photovoltaic halides based on edge-shared AX6 and BX6 octahedra with the general formula Aa Bb Xx (x=a+3 b) such as Ag3 BiI6 , Ag2 BiI5 , AgBiI4 , AgBi2 I7 ...
October 9, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28638068/microbiota-derived-butyrate-suppresses-group-3-innate-lymphoid-cells-in-terminal-ileal-peyer-s-patches
#8
Sae-Hae Kim, Byeol-Hee Cho, Hiroshi Kiyono, Yong-Suk Jang
The regional specialization of intestinal immune cells is affected by the longitudinal heterogeneity of environmental factors. Although the distribution of group 3 innate lymphoid cells (ILC3s) is well characterized in the lamina propria, it is poorly defined in Peyer's patches (PPs) along the intestine. Given that PP ILC3s are closely associated with mucosal immune regulation, it is important to characterize the regulatory mechanism of ILC3s. Here, we found that terminal ileal PPs of specific pathogen-free (SPF) mice have fewer NKp46(+) ILC3s than jejunal PPs, while there was no difference in NKp46(+) ILC3 numbers between terminal ileal and jejunal PPs in antibiotics (ABX)-treated mice...
June 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28558755/evaluation-of-a-species-specific-c-reactive-protein-assay-for-the-dog-on-the-abx-pentra-400-clinical-chemistry-analyzer
#9
Sarah Hindenberg, Stefanie Klenner-Gastreich, Nicole Kneier, Sabine Zielinsky, Kris Gommeren, Natali Bauer, Andreas Moritz
BACKGROUND: A canine-specific immunoturbidimetric CRP assay, Gentian Canine CRP Immunoassay) with species-specific controls and calibrators was introduced and recently evaluated on the clinical chemistry analyzer Abbott Architect c4000 as well as on the Olympus AU600. Aims of our study were 1) to independently evaluate the canine-specific CRP assay on the ABX Pentra 400 clinical chemistry analyzer in comparison to the previously validated human-based immunoturbidimetric assay (Randox Canine CRP assay) and 2) to assess the impact of different sample types (serum versus heparinized plasma) on the results...
May 30, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28469619/immune-responses-to-broad-spectrum-antibiotic-treatment-and-fecal-microbiota-transplantation-in-mice
#10
Ira Ekmekciu, Eliane von Klitzing, Ulrike Fiebiger, Ulrike Escher, Christian Neumann, Petra Bacher, Alexander Scheffold, Anja A Kühl, Stefan Bereswill, Markus M Heimesaat
Compelling evidence demonstrates the pivotal role of the commensal intestinal microbiota in host physiology and the detrimental effects of its perturbations following antibiotic treatment. Aim of this study was to investigate the impact of antibiotics induced depletion and subsequent restoration of the intestinal microbiota composition on the murine mucosal and systemic immunity. To address this, conventional C57BL/6j mice were subjected to broad-spectrum antibiotic treatment for 8 weeks. Restoration of the intestinal microbiota by peroral fecal microbiota transplantation (FMT) led to reestablishment of small intestinal CD4(+), CD8(+), and B220(+) as well as of colonic CD4(+) cell numbers as early as 7 days post-FMT...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28394751/practice-patterns-for-the-use-of-antibiotic-agents-in-damage-control-laparotomy-and-its-impact-on-outcomes
#11
Stephanie R Goldberg, Jennifer Henning, Luke G Wolfe, Therese M Duane
BACKGROUND: The purpose of this study was to identify practice patterns associated with the use of antimicrobial agents with damage control laparotomy (DCL) and the relationship with post-operative intra-abdominal infection (IAI) rates. PATIENTS AND METHODS: The study was a retrospective review of trauma patients undergoing laparotomy at a Level 1 trauma center in 2010. Patients undergoing DCL versus those primarily closed (PCL) were compared for antimicrobial use (ABX) and its correlation with IAI rates (p < 0...
April 2017: Surgical Infections
https://www.readbyqxmd.com/read/28378801/antibody-targeted-paclitaxel-loaded-nanoparticles-for-the-treatment-of-cd20-b-cell-lymphoma
#12
Wendy K Nevala, John T Butterfield, Shari L Sutor, Daniel J Knauer, Svetomir N Markovic
We developed a nano-antibody targeted chemotherapy (nATC) delivery strategy in which tumor specific and clinically relevant antibodies (rituximab, anti-CD20) are non-covalently bound to the albumin scaffold of nab-paclitaxel (ABX). We define the nanoparticle formed when the 2 drugs are bound (AR160). The newly created nATC retains the cytotoxicity of ABX and CD20 affinity of rituximab in vitro. We describe the binding characteristics of the ABX and rituximab in AR160 using peptide mapping/Biacore approach. Flow-based methods, including ImageStream and nanoparticle tracking, were used to characterize the AR160 particles in vitro...
April 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28290524/gut-dysbiosis-and-neuroimmune-responses-to-brain-infection-with-theiler-s-murine-encephalomyelitis-virus
#13
F J Carrillo-Salinas, L Mestre, M Mecha, A Feliú, R Del Campo, N Villarrubia, C Espejo, X Montalbán, J C Álvarez-Cermeño, L M Villar, C Guaza
Recent studies have begun to point out the contribution of microbiota to multiple sclerosis (MS) pathogenesis. Theiler's murine encephalomyelitis virus induced demyelinating disease (TMEV-IDD) is a model of progressive MS. Here, we first analyze the effect of intracerebral infection with TMEV on commensal microbiota and secondly, whether the early microbiota depletion influences the immune responses to TMEV on the acute phase (14 dpi) and its impact on the chronic phase (85 dpi). The intracranial inoculation of TMEV was associated with a moderate dysbiosis...
March 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28257503/depletion-of-enteric-bacteria-diminishes-leukocyte-infiltration-following-doxorubicin-induced-small-intestinal-damage-in-mice
#14
Jacquelyn S Carr, Stephanie King, Christopher M Dekaney
BACKGROUND & AIMS: While enteric bacteria have been shown to play a critical role in other forms of intestinal damage, their role in mediating the response to the chemotherapeutic drug Doxorubicin (Doxo) is unclear. In this study, we used a mouse model of intestinal bacterial depletion to evaluate the role enteric bacteria play in mediating Doxo-induced small intestinal damage and, more specifically, in mediating chemokine expression and leukocyte infiltration following Doxo treatment...
2017: PloS One
https://www.readbyqxmd.com/read/28237482/effects-of-the-hydro-ethanolic-extract-of-marrubium-vulgare-in-female-rats
#15
Rim Aouni, Mossadok Ben Attia, Mohamed Habib Jaafoura, Amina Bibi-Derbel, Mustapha Haouari
OBJECTIVE: To evaluate the effects of ethanol-water (80:20) extract of Marrubium vulgare (M. vulgare) on the hematological parameters, macroscopic and histological aspects of the uterus and fetus in non-pregnant and pregnant rats. METHODS: Female rats were divided into 4 equal groups (n = 9), group N (normal rats) and group G (pregnant rats) considered as control groups, group NE (normal rats treated with the ethanol-water (80:20, v/v) extract of M. vulgare) and group GE (pregnant rats treated with the extract)...
February 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28211545/the-effect-of-gut-microbiome-on-tolerance-to-morphine-mediated-antinociception-in-mice
#16
Minho Kang, Ryan A Mischel, Sukhada Bhave, Essie Komla, Alvin Cho, Charity Huang, William L Dewey, Hamid I Akbarali
There is growing appreciation for the importance of gastrointestinal microbiota in many physiological and pathophysiological processes. While morphine and other narcotics are the most widely prescribed therapy for moderate to severe pain clinically, they have been noted to alter microbial composition and promote bacterial translocation to other tissues. Here we examined the pharmacodynamic properties of chronic morphine in mice following bacterial depletion with oral gavage of an antibiotic cocktail (ABX). ABX significantly reduced gut bacteria and prevented chronic morphine induced increases in gut permeability, colonic mucosal destruction, and colonic IL-1β expression...
February 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28190080/predicting-favorable-and-unfavorable-consequences-of-perceptual-learning-worsening-and-the-peak-shift
#17
Matthew G Wisniewski
Discrimination learning can cause improved and worsened ability to perceive differences. This subsequently affects how stimuli are associated with meanings and behaviors. Here, human listeners were trained with frequency-modulated (FM) tonal sweeps (500-1000 Hz) in a paradigm where one FM rate (8.29 octaves per second) required a 'Target' response, while a rate either slower (5.76 octaves per second) or faster (11.94 octaves per second) required a 'Non-Target' response. Training led to a shift in 'Target' responding along the FM rate dimension away from the 'Target' in a direction opposite the trained 'Non-Target'...
April 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28152702/improving-the-treatment-of-patients-with-low-risk-neutropenic-fever-a-quality-improvement-project-at-the-cleveland-clinic-taussig-cancer-institute-tci
#18
Jessica Lau, Erika M Gallagher, Machelle Moeller, Carolyn Best, James Stevenson
101 Background: NF is an oncologic emergency and has historically resulted in inpatient (inpt) management. The Multinational Association for Supportive Care in Cancer (MASCC) score can be used to identify NF pts at LR for complications who can be safely managed in the outpatient (outpt) setting. Despite established guidelines supporting outpt management of LRNF, provider awareness is low and inpt admission for intravenous antibiotics (abx) continues to be standard of care. METHODS: A multidisciplinary team performed a QI project to improve management of LRNF (baseline cohort of LRNF pts treated from Jan - Mar 2014, N = 13)...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28034915/early-life-antibiotic-treatment-enhances-the-pathogenicity-of-cd4-t-cells-during-intestinal-inflammation
#19
Sebastian Scheer, Tiago S Medina, Alex Murison, Matthew D Taves, Frann Antignano, Alistair Chenery, Kiran K Soma, Georgia Perona-Wright, Mathieu Lupien, Cheryl H Arrowsmith, Daniel D De Carvalho, Colby Zaph
The incidence of inflammatory bowel diseases (IBDs) has steadily increased in recent decades-a phenomenon that cannot be explained by genetic mutations alone. Other factors, including the composition of the intestinal microbiome, are potentially important contributors to the increased occurrence of this group of diseases. Previous reports have shown a correlation between early-life antibiotic (Abx) treatment and an increased incidence of IBD. In this report, we investigated the effects of early-life Abx treatments on the pathogenicity of CD4(+) T cells using an experimental T cell transfer model of IBD...
April 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/27999038/pharmacokinetics-and-tolerability-of-abx464-a-novel-first-in-class-compound-to-treat-hiv-infection-in-healthy-hiv-uninfected-subjects
#20
Didier Scherrer, Regine Rouzier, P Noel Barrett, Jean-Marc Steens, Paul Gineste, Robert L Murphy, Jamal Tazi, Hartmut J Ehrlich
Background: An anti-HIV compound (ABX464) has been developed with a novel mechanism of activity in that it blocks viral gene expression in cells that are already infected. Objectives: A first-in-man study was conducted to determine the pharmacokinetic and safety profiles of ABX464. This was carried out as an open label, parallel group, single ascending dose, exploratory study. Methods: Twenty-four male subjects in good health without HIV infection, aged from 18 to 55 years old, with BMIs of 18-27 kg/m 2 were included...
March 1, 2017: Journal of Antimicrobial Chemotherapy
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