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https://www.readbyqxmd.com/read/29625700/quality-of-life-in-cushing-s-disease-a-long-term-issue
#1
Susan M Webb, Alicia Santos, Eugenia Resmini, Maria-Antonia Martínez-Momblán, Luciana Martel, Elena Valassi
The purpose of this review is to describe how quality of life (QoL) is impaired in patients with hypercortisolism due to Cushing's syndrome of any aetiology, including pituitary-dependent Cushing's disease. It is worse in active disease, but improvement after successful therapy is often incomplete, due to persistent physical and psychological co-morbidities, even years after endocrine "cure". Physical symptoms like extreme fatigability, central obesity with limb atrophy, hypertension, fractures, and different skin abnormalities severely impair the affected patients' everyday life...
April 3, 2018: Annales D'endocrinologie
https://www.readbyqxmd.com/read/29574994/worse-health-related-quality-of-life-at-long-term-follow-up-in-patients-with-cushing-s-disease-than-patients-with-cortisol-producing-adenoma-data-from-the-ercusyn
#2
Elena Valassi, Richard Feelders, Dominique Maiter, Philippe Chanson, Maria Yaneva, Martin Reincke, Michal Krsek, Miklós Tóth, Susan M Webb, Alicia Santos, Isabel Paiva, Irina Komerdus, Michael Droste, Antoine Tabarin, Christian J Strasburger, Holger Franz, Peter J Trainer, John Newell-Price, John Ah Wass, Eleni Papakokkinou, Oskar Ragnarsson
OBJECTIVE: Hypercortisolism in Cushing's syndrome (CS) is associated with impaired health-related quality of life (HRQoL), which may persist despite remission. We used the data entered into the European Registry on Cushing's syndrome (ERCUSYN) to evaluate if patients with CS of pituitary origin (PIT-CS) have worse HRQoL, both before and after treatment than patients with adrenal causes (ADR-CS). METHODS: Data from 595 patients (492 women; 83%) who completed the CushingQoL and/or EQ-5D questionnaires at baseline and/or following treatment were analysed...
March 24, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29415222/military-tailored-yoga-for-veterans-with-post-traumatic-stress-disorder
#3
Robin E Cushing, Kathryn L Braun, Susan W Alden C-Iayt, Alan R Katz
Introduction: Among veterans of post-9/11 conflicts, estimates of post-traumatic stress disorder (PTSD) range from 9% shortly after returning from deployment to 31% a year after deployment. Clinical and pharmaceutically based treatments are underutilized. This could be due to concerns related to lost duty days, as well as PTSD patients' fears of stigma of having a mental health condition. Yoga has been shown to reduce PTSD symptoms in the civilian population, but few studies have tested the impact of yoga on veterans of post-9/11 conflicts...
February 5, 2018: Military Medicine
https://www.readbyqxmd.com/read/29223281/human-studies-on-hypothalamo-pituitary-adrenal-hpa-axis
#4
REVIEW
Kamani Liyanarachchi, Richard Ross, Miguel Debono
The daily rhythm of the hypothalamo-pituitary-adrenal (HPA) axis is regulated by the central clock in the suprachiasmatic nucleus. Cortisol, a glucocorticoid, acts as a secondary messenger between the central clock and the peripheral tissues. Changes in clock time, as seen in shift workers, alters the HPA axis and results in metabolic disturbances associated with ill health. Depression, anorexia nervosa and obstructive sleep apnoea, are associated with cortisol rhythm phase shifts and increased cortisol exposure...
October 2017: Best Practice & Research. Clinical Endocrinology & Metabolism
https://www.readbyqxmd.com/read/29212586/hypercortisolemia-and-depressive-like-behaviors-in-a-rhesus-macaque-macaca-mulatta-involved-in-visual-research
#5
Sean C Adams, Christine M Guyot, Kristina M Berry, Seth T Wallack, Andrew S Loar, Mathias Leblanc
A 10-y-old cranially implanted rhesus macaque (Macaca mulatta) involved in visual research was presented for dull mentation and weight loss. Physical examination revealed alopecia and poor body conditioning, and bloodwork revealed marked hypercortisolemia (23 μg/dL). Differential diagnoses for hypercortisolemia, weight loss, and alopecia included Cushing and pseudo-Cushing syndromes. To further evaluate hypercortisolemia, we compared the urine cortisol:creatinine ratio (UCCR) at baseline and after low-dose dexamethasone suppression (LDDS) testing in the presenting animal and healthy naïve and implanted working monkeys...
December 1, 2017: Comparative Medicine
https://www.readbyqxmd.com/read/29134965/depression-is-associated-with-more-aggressive-inflammatory-bowel-disease
#6
Bharati Kochar, Edward L Barnes, Millie D Long, Kelly C Cushing, Joseph Galanko, Christopher F Martin, Laura E Raffals, Robert S Sandler
OBJECTIVES: Depression is prevalent in inflammatory bowel disease (IBD) patients. The impact of depression on IBD is not well-studied. It is unknown how providers should assess depression. METHODS: We used data from the Sinai-Helmsley Alliance for Research Excellence cohort, to assess methods of diagnosing depression and effects of baseline depression on disease activity at follow-up. A patient health questionnaire (PHQ-8) score ≥5 was consistent with mild depression...
January 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28917948/effects-of-methamphetamine-on-alloparental-behavior-in-male-and-female-prairie-voles
#7
Adam N Perry, Richard J Ortiz, Keziah R Hernandez, Bruce S Cushing
Psychostimulant abuse is associated with a variety of impairments in social functioning, including an increased frequency of depression and aggression and deficits in social cognition. Psychostimulants reduce social investigation in rats and mice; however, it is less clear how other forms of social behavior (e.g., prosocial behavior) are affected. Females are also generally more sensitive to the effects of psychostimulants on locomotion and stereotyped behavior, which suggests that females might also display greater disruption of prosocial behavior...
September 14, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28607927/depression-and-anxiety-scores-are-associated-with-amygdala-volume-in-cushing-s-syndrome-preliminary-study
#8
Alicia Santos, Esther Granell, Beatriz Gómez-Ansón, Iris Crespo, Patricia Pires, Yolanda Vives-Gilabert, Elena Valassi, Susan M Webb, Eugenia Resmini
INTRODUCTION: Cushing's syndrome (CS) has repeatedly been associated with hippocampal volume reductions, while little information is available on the amygdala, another structure rich in glucocorticoid receptors. The aim of the study was to analyze amygdala volume in patients with CS and its relationship with anxiety, depression, and hormone levels. MATERIAL AND METHODS: 39 CS patients (16 active and 23 patients in remission) and 39 healthy controls matched for age, sex, and education level completed anxiety (STAI) and depression tests (BDI-II) and underwent a 3 Tesla brain MRI and endocrine testing...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28515565/cushing-s-syndrome-and-treatment-resistant-depression
#9
Lekhansh Shukla
No abstract text is available yet for this article.
March 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/28393326/psychiatric-symptoms-in-patients-with-cushing-s-syndrome-prevalence-diagnosis-and-management
#10
REVIEW
Alicia Santos, Eugenia Resmini, Juan Carlos Pascual, Iris Crespo, Susan M Webb
Cushing's syndrome (CS) results from chronic exposure to cortisol excess, produced by the adrenal cortex. Hypercortisolism predisposes to psychiatric and neurocognitive disorders, mainly to depression and anxiety disorders. Screening tools to identify psychiatric symptoms are available for clinicians in their daily practice, although a specific diagnosis should be performed by specialists. Even if psychiatric symptoms improve after remission of hypercortisolism, complete recovery may not be achieved. Given the burden of these symptoms, psychiatric or psychological monitoring and treatment should be offered through all phases of CS, with a multidisciplinary approach...
May 2017: Drugs
https://www.readbyqxmd.com/read/28391254/primary-pigmented-nodular-adrenocortical-disease-literature-review-and-case-report-of-a-6-year-old-boy
#11
Dragan Katanić, Dejan Kafka, Mirjana Živojinov, Jovan Vlaški, Zorana Budakov, Marija Knežević Pogančev, Ivana Vorgučin, Tomislav Ćuk
Cushing's syndrome is rare in childhood and is usually caused by a pituitary adenoma. Primary hyperfunction of adrenal glands is less frequent, particularly primary pigmented nodular adrenocortical disease (PPNAD). It occurs usually in children and adolescents, with female preponderance, while Cushing's disease has increased frequency in prepubertal males. A case of a 6-year-old boy is presented with isolated non-familiar PPNAD. The clinical pattern involved Cushingoid appearance, hypertension, virilization and depressive mood...
April 10, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28332051/white-matter-involvement-on-dti-mri-in-cushing-s-syndrome-relates-to-mood-disturbances-and-processing-speed-a-case-control-study
#12
Patricia Pires, Alicia Santos, Yolanda Vives-Gilabert, Susan M Webb, Aitor Sainz-Ruiz, Eugenia Resmini, Iris Crespo, Manel de Juan-Delago, Beatriz Gómez-Anson
PURPOSE: Cushing's syndrome (CS) is an endocrine disorder due to prolonged exposure to cortisol. Recently, microstructural white matter (WM) alterations detected by diffusion tensor imaging (DTI) have been reported in CS patients, and related to depression, but other functional significances. remain otherwise unclear. We aimed at investigating in more depth mood symptoms in CS patients, and how these relate to cognition (information processing speed), and to WM alterations on DTI. METHODS: The sample comprised 35 CS patients and 35 healthy controls...
June 2017: Pituitary
https://www.readbyqxmd.com/read/28300138/reduced-dna-methylation-and-psychopathology-following-endogenous-hypercortisolism-a-genome-wide-study
#13
Camilla A M Glad, Johanna C Andersson-Assarsson, Peter Berglund, Ragnhildur Bergthorsdottir, Oskar Ragnarsson, Gudmundur Johannsson
Patients with Cushing's Syndrome (CS) in remission were used as a model to test the hypothesis that long-standing excessive cortisol exposure induces changes in DNA methylation that are associated with persisting neuropsychological consequences. Genome-wide DNA methylation was assessed in 48 women with CS in long-term remission (cases) and 16 controls matched for age, gender and education. The Fatigue impact scale and the comprehensive psychopathological rating scale were used to evaluate fatigue, depression and anxiety...
March 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/27986975/roles-of-hippocampal-somatostatin-receptor-subtypes-in-stress-response-and-emotionality
#14
Thomas D Prévôt, François Gastambide, Cécile Viollet, Nadia Henkous, Guillaume Martel, Jacques Epelbaum, Daniel Béracochéa, Jean-Louis Guillou
Altered brain somatostatin functions recently appeared as key elements for the pathogenesis of stress-related neuropsychiatric disorders. The hippocampus exerts an inhibitory feedback on stress but the mechanisms involved remain unclear. We investigated herein the role of hippocampal somatostatin receptor subtypes in both stress response and behavioral emotionality using C57BL/6, wild type and sst2 or sst4 knockout mice. Inhibitory effects of hippocampal infusions of somatostatin agonists on stress-induced hypothalamo-pituitary-adrenal axis (HPA) activity were tested by monitoring peripheral blood and local hippocampus corticosterone levels, the latter by using microdialysis...
July 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27932530/affective-alterations-in-patients-with-cushing-s-syndrome-in-remission-are-associated-with-decreased-bdnf-and-cortisone-levels
#15
E Valassi, I Crespo, B G Keevil, A Aulinas, E Urgell, A Santos, P J Trainer, S M Webb
OBJECTIVE: Affective alterations and poorer quality of life often persist in patients with Cushing's syndrome (CS) in remission. Brain-derived neurotrophic factor (BDNF) regulates the hypothalamic-pituitary-adrenal axis (HPA) and is highly expressed in brain areas controlling mood and response to stress. Our aims were to assess affective alterations after long-term remission of CS and evaluate whether they are associated with serum BDNF, salivary cortisol (SalF) and/or cortisone (SalE) concentrations...
February 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/27805343/cushing-s-disease-presenting-as-suicidal-depression
#16
Jatinder Mokta, Ravi Sharma, Kiran Mokta, Asha Ranjan, Prashant Panda, Ivan Joshi
A case of Cushing disease, who presented with suicidal depression as the main complaint is reported. Prompt diagnosis and early management of the underlying cause of Cushing's disease, not only relieved features of hypercortisolaemia but also remitted depression fully.
November 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27590785/coping-strategies-have-a-strong-impact-on-quality-of-life-depression-and-embitterment-in-patients-with-cushing-s-disease
#17
Sonja Siegel, Monika Milian, Bernadette Kleist, Tsambika Psaras, Maria Tsiogka, Dagmar Führer, Maria Koltowska-Häggström, Jürgen Honegger, Oliver Müller, Ulrich Sure, Christa Menzel, Michael Buchfelder, Ilonka Kreitschmann-Andermahr
PURPOSE: Quality of life (QoL) and psychosocial well-being are substantially impaired in patients with Cushing's disease (CD), not only at the acute illness stage but also after therapy; however, the reason for these impairments remains unclear. METHODS: In this cross-sectional, patient-reported outcome study, we conducted a postal survey on psychosocial impairment and coping strategies in patients after surgical treatment of CD in three large tertiary referral centers...
December 2016: Pituitary
https://www.readbyqxmd.com/read/27541315/distinct-cortical-signatures-associated-with-sedation-and-respiratory-rate-depression-by-morphine-in-a-pediatric-population
#18
Gaspard Montandon, Sharon L Cushing, Fiona Campbell, Evan J Propst, Richard L Horner, Indra Narang
BACKGROUND: Opioid analgesia is an essential component of perioperative care, but effective analgesia can be limited by excessive sedation and respiratory depression. The cortical signatures associated with sedation by opioids and the relationship between changes in cortical activity and respiratory function are not well understood. The objectives of this study were to identify the electroencephalogram signatures of sedation and respiratory changes induced by morphine in a pediatric population after elective surgery...
November 2016: Anesthesiology
https://www.readbyqxmd.com/read/27515536/cushing-s-syndrome-and-steroid-dementia
#19
REVIEW
Giampaolo Bernini, Domenico Tricò
Cushing's Syndrome (CS) is associated with a specific spectrum of dementia-like symptoms, including psychiatric disorders, such as major depression, anxiety and mania, and neurocognitive alterations, like impairment of memory and concentration. This pattern of clinical complications, which significantly impair the health-related quality of life of CS patients, is sometimes referred to as "steroid dementia syndrome" (SDS). The SDS is the result of anatomical and functional anomalies in brain areas involved in the processing of emotion and cognition, which are only partially restored after the biochemical remission of the disease...
2016: Recent Patents on Endocrine, Metabolic & Immune Drug Discovery
https://www.readbyqxmd.com/read/27379791/effective-electroconvulsive-therapy-in-a-patient-with-psychotic-depression-with-active-cushing-disease
#20
LETTER
Geeske van Rooijen, Damiaan Denys, Eric Fliers, Max Nieuwdorp
No abstract text is available yet for this article.
September 2016: Journal of ECT
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