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https://www.readbyqxmd.com/read/29331992/effectiveness-of-interventions-for-reducing-non-occupational-sedentary-behaviour-in-adults-and-older-adults-a-systematic-review-and-meta-analysis
#1
REVIEW
Nipun Shrestha, Jozo Grgic, Glen Wiesner, Alexandra Parker, Hrvoje Podnar, Jason A Bennie, Stuart J H Biddle, Zeljko Pedisic
BACKGROUND: No systematic reviews of the effectiveness of interventions for reducing non-occupational sedentary behaviour are available. Therefore, the aim of this systematic review was to assess the effectiveness of interventions for reducing non-occupational sedentary behaviour in adults and older adults. METHODS: An electronic search of nine databases was performed. Randomised controlled trials (RCT) and cluster RCTs among adults testing the effectiveness of interventions aimed to reduce non-occupational sedentary behaviour were considered for inclusion...
January 13, 2018: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/29331706/the-association-between-adherence-and-outcome-in-an-internet-intervention-for-depression
#2
Kristina Fuhr, Johanna Schröder, Thomas Berger, Steffen Moritz, Björn Meyer, Wolfgang Lutz, Fritz Hohagen, Martin Hautzinger, Jan Philipp Klein
BACKGROUND: Adherence to Internet interventions is often reported to be rather low and this might adversely impact the effectiveness of these interventions. We investigated if patient characteristics are associated with adherence, and if adherence is associated with treatment outcome in a large RCT of an Internet intervention for depression, the EVIDENT trial. METHODS: Patients were randomized to either care as usual (CAU) or CAU plus the Internet intervention Deprexis...
December 27, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29331519/understanding-and-misunderstanding-randomized-controlled-trials
#3
Angus Deaton, Nancy Cartwright
Randomized Controlled Trials (RCTs) are increasingly popular in the social sciences, not only in medicine. We argue that the lay public, and sometimes researchers, put too much trust in RCTs over other methods of investigation. Contrary to frequent claims in the applied literature, randomization does not equalize everything other than the treatment in the treatment and control groups, it does not automatically deliver a precise estimate of the average treatment effect (ATE), and it does not relieve us of the need to think about (observed or unobserved) covariates...
December 25, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/29331506/hepatocyte-estrogen-receptor-alpha-mediates-estrogen-action-to-promote-reverse-cholesterol-transport-during-western-type-diet-feeding
#4
Lin Zhu, Jeanne Shi, Thao N Luu, Joshua C Neuman, Elijah Trefts, Sophia Yu, Brian T Palmisano, David H Wasserman, MacRae F Linton, John M Stafford
OBJECTIVE: Hepatocyte deletion of estrogen receptor alpha (LKO-ERα) worsens fatty liver, dyslipidemia, and insulin resistance in high-fat diet fed female mice. However, whether or not hepatocyte ERα regulates reverse cholesterol transport (RCT) in mice has not yet been reported. METHODS AND RESULTS: Using LKO-ERα mice and wild-type (WT) littermates fed a Western-type diet, we found that deletion of hepatocyte ERα impaired in vivo RCT measured by the removal of 3H-cholesterol from macrophages to the liver, and subsequently to feces, in female mice but not in male mice...
December 29, 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/29331262/can-interrogation-of-tumour-characteristics-lead-us-to-safely-omit-adjuvant-radiotherapy-in-patients-with-early-breast-cancer
#5
I S Bhattacharya, A M Kirby, J M Bliss, C E Coles
Adjuvant radiotherapy after breast-conserving surgery has been an important component of the standard of care for early breast cancer. Improvements in breast cancer care have resulted in a substantial reduction in local relapse rates over recent decades. Although the proportional benefits of adjuvant radiotherapy are similar for different prognostic risk groups of patients, the absolute benefits depend on the risk of relapse and therefore vary considerably between prognostic groups. Radiotherapy is not without risk and for some patients at very low risk of relapse the risks of radiotherapy may outweigh the benefit, leading to potential overtreatment...
January 10, 2018: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/29330103/osteoarthritis-year-in-review-2017-rehabilitation-and-outcomes
#6
REVIEW
Dieuwke Schiphof, Jacoline J van den Driest, Jos Runhaar
OBJECTIVE: The purpose of this systematic review was to describe studies examining rehabilitation for people with osteoarthritis (OA) and to summarize findings from selected key systematic reviews (SRs) and randomized controlled trials (RCTs). DESIGN: A systematic search was performed using Pubmed, Embase and Cochrane databases from April 1st 2016 to May 15th 2017 using the terms 'osteoarthritis', 'randomized controlled trial', and 'systematic review'. Inclusion criteria were: clinically or radiologically diagnosed patients with osteoarthritis, rehabilitation treatment, RCT or SRs...
January 9, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29330101/telephone-based-weight-loss-support-for-patients-with-knee-osteoarthritis-a-pragmatic-randomized-controlled-trial
#7
Kate M O'Brien, John Wiggers, Amanda Williams, Elizabeth Campbell, Rebecca K Hodder, Luke Wolfenden, Sze Lin Yoong, Emma K Robson, Robin Haskins, Steven J Kamper, Chris Rissel, Christopher M Williams
OBJECTIVE: To determine the effectiveness of telephone-based weight loss support in reducing the intensity of knee pain in patients with knee osteoarthritis, who are overweight or obese, compared to usual care. DESIGN: We conducted a parallel randomized controlled trial (RCT), embedded within a cohort multiple RCT of patients on a waiting list for outpatient orthopaedic consultation at a tertiary referral hospital in NSW, Australia. Patients with knee osteoarthritis, classified as overweight or obese (body mass index between ≥27kg/m2 and <40kg/m2) were randomly allocated to receive referral to an existing non-disease specific government funded 6-month telephone-based weight management and healthy lifestyle service or usual care...
January 9, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29329567/modified-pilates-as-an-adjunct-to-standard-physiotherapy-care-for-urinary-incontinence-a-mixed-methods-pilot-for-a-randomised-controlled-trial
#8
Adi Lausen, Louise Marsland, Samantha Head, Joanna Jackson, Berthold Lausen
BACKGROUND: Urinary incontinence (UI) is a distressing condition affecting at least 5 million women in England and Wales. Traditionally, physiotherapy for UI comprises pelvic floor muscle training, but although evidence suggests this can be effective it is also recognised that benefits are often compromised by patient motivation and commitment. In addition, there is increasing recognition that physical symptoms alone are poor indicators of the impact of incontinence on individuals' lives...
January 12, 2018: BMC Women's Health
https://www.readbyqxmd.com/read/29329486/cost-effectiveness-of-guided-internet-based-interventions-for-depression-in-comparison-with-control-conditions-an-individual-participant-data-meta-analysis
#9
REVIEW
Spyros Kolovos, Johanna M van Dongen, Heleen Riper, Claudia Buntrock, Pim Cuijpers, David D Ebert, Anna S Geraedts, Robin M Kenter, Stephanie Nobis, Andrea Smith, Lisanne Warmerdam, Jill A Hayden, Maurits W van Tulder, Judith E Bosmans
BACKGROUND: There is limited evidence on the cost effectiveness of Internet-based treatments for depression. The aim was to evaluate the cost effectiveness of guided Internet-based interventions for depression compared to controls. METHODS: Individual-participant data from five randomized controlled trials (RCT), including 1,426 participants, were combined. Cost-effectiveness analyses were conducted at 8 weeks, 6 months, and 12 months follow-up. RESULTS: The guided Internet-based interventions were more costly than the controls, but not statistically significant (12 months mean difference = €406, 95% CI: - 611 to 1,444)...
January 12, 2018: Depression and Anxiety
https://www.readbyqxmd.com/read/29329046/social-distance-toward-people-with-schizophrenia-is-associated-with-favorable-understanding-and-negative-stereotype
#10
Shinsuke Koike, Sosei Yamaguchi, Yasutaka Ojio, Shuntaro Ando
Previous studies have suggested the consequence of mental health-related public stigma: the problem of knowledge may develop into problem of attitude and behaviour. However, this has not been directly explored in a longitudinal study. As the secondary analysis from our previous randomized controlled trial (RCT) for 219 participants who completed the survey at the 12-month follow-up, we aimed to investigate whether the knowledge and attitude components of stigma toward people with schizophrenia affect each other...
January 2, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29326183/transvaginal-natural-orifice-transluminal-endoscopic-surgery-vnotes-adnexectomy-for-benign-pathology-compared-with-laparoscopic-excision-notable-a-protocol-for-a-randomised-controlled-trial
#11
Jan Filip Baekelandt, Peter A De Mulder, Ilse Le Roy, Chantal Mathieu, Annouschka Laenen, Paul Enzlin, Steven Weyers, Ben W J Mol, Jan J A Bosteels
INTRODUCTION: Natural orifice transluminal endoscopic surgery (NOTES) uses natural orifices to access the cavities of the human body to perform surgical interventions. NOTES limits the magnitude of surgical trauma and potentially reduces postoperative pain. Our group published a protocol on a randomised study comparing transvaginal NOTES (vNOTES) versus laparoscopy for hysterectomy (HALON). We simultaneously designed a similar randomised controlled trial (RCT) comparing vNOTES with laparoscopy for adnexectomy...
January 10, 2018: BMJ Open
https://www.readbyqxmd.com/read/29326094/a-shared-decision-making-tool-to-prevent-substance-abuse-protocol-for-a-randomized-controlled-trial
#12
Ju Long, Juntao Michael Yuan, Ron Kim Johnson
BACKGROUND: Substance use disorder (SUD) affects over 20 million adults and costs over $700 billion annually in the United States. It is one the greatest health care challenges we face. OBJECTIVE: This research project seeks to enhance the standard practice of Screening, Brief Intervention, and Referral to Treatment (SBIRT) through a mobile solution easily incorporated into primary care that will promote shared decision making and increase referral and adherence to specialty care through continued follow-up care...
January 11, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29325703/the-prevalence-and-morphometric-analysis-of-ossified-superior-transverse-scapular-ligaments-in-patients-with-rotator-cuff-tears
#13
Jung Youn Kim, Yong Girl Rhee
BACKGROUND: The prevalence of ossified superior transverse scapular ligaments (OSTSLs) in rotator cuff tears (RCTs) has not yet been determined. The purposes of this study were to evaluate the prevalence of OSTSLs in RCTs and to investigate the correlation between OSTSL morphology and supraspinatus muscle atrophy. METHODS: We analyzed a total of 213 patients with RCTs for whom 3-dimensional (3D) computed tomography (CT) and magnetic resonance imaging were performed prior to arthroscopic procedures...
January 8, 2018: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29325577/dynamic-kinematics-of-the-glenohumeral-joint-in-shoulders-with-rotator-cuff-tears
#14
Naoya Kozono, Takamitsu Okada, Naohide Takeuchi, Satoshi Hamai, Hidehiko Higaki, Takeshi Shimoto, Satoru Ikebe, Hirotaka Gondo, Yoshitaka Nakanishi, Takahiro Senju, Yasuharu Nakashima
BACKGROUND: No clear trend has emerged from the literature regarding three-dimensional (3D) translations of the humerus relative to the scapula in shoulders with rotator cuff tears (RCTs). The purpose of this study was to evaluate the kinematics of RCT shoulders using 3D-to-two-dimensional (2D) model-to-image registration techniques. METHODS: Dynamic glenohumeral kinematics during scapular plane abduction and axial rotation were analyzed in 11 RCT patients and 10 healthy control subjects...
January 11, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29325517/a-cluster-randomised-controlled-trial-evaluating-the-effectiveness-and-cost-effectiveness-of-the-daily-mile-on-childhood-obesity-and-wellbeing-the-birmingham-daily-mile-protocol
#15
Katie Breheny, Peymane Adab, Sandra Passmore, James Martin, Emma Lancashire, Karla Hemming, Emma Frew
BACKGROUND: Childhood obesity prevention is a public health priority. Children spend a large proportion of their waking time in school; therefore this is an appropriate setting to implement obesity prevention initiatives. Anecdotal reports suggest that implementing The Daily Mile in schools has had positive effects on childhood obesity, academic attainment and wellbeing. This trial aims to measure the effectiveness of The Daily Mile for improving health and wellbeing. METHODS: This protocol describes a cluster randomised controlled trial (RCT) in 40 primary schools located in Birmingham, UK...
January 11, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29325223/maternal-thyroid-hormone-insufficiency-during-pregnancy-and-risk-of-neurodevelopmental-disorders-in-offspring-a-systematic-review-and-meta-analysis
#16
William Thompson, Ginny Russell, Genevieve Baragwanath, Justin Matthews, Bijay Vaidya, Jo Thompson-Coon
BACKGROUND: In the last two decades, several studies have examined the association between maternal thyroid hormone insufficiency during pregnancy and neurodevelopmental disorders in children and shown conflicting results. AIM: This systematic review aimed to assess the evidence for an association between maternal thyroid hormone insufficiency during pregnancy and neurodevelopmental disorders in children. We also sought to assess whether levothyroxine treatment for maternal thyroid hormone insufficiency improves child neurodevelopment outcomes...
January 11, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29324498/five-steps-to-successfully-implement-and-evaluate-propensity-score-matching-in-clinical-research-studies
#17
Steven J Staffa, David Zurakowski
In clinical research, the gold standard level of evidence is the randomized controlled trial (RCT). The availability of nonrandomized retrospective data is growing; however, a primary concern of analyzing such data is comparability of the treatment groups with respect to confounding variables. Propensity score matching (PSM) aims to equate treatment groups with respect to measured baseline covariates to achieve a comparison with reduced selection bias. It is a valuable statistical methodology that mimics the RCT, and it may create an "apples to apples" comparison while reducing bias due to confounding...
January 9, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29322428/feasibility-of-the-evidence-based-cognitive-telerehabilitation-program-remind-for-patients-with-primary-brain-tumors
#18
Sophie D van der Linden, Margriet M Sitskoorn, Geert-Jan M Rutten, Karin Gehring
Many patients with primary brain tumors experience cognitive deficits. Cognitive rehabilitation programs focus on alleviating these deficits, but availability of such programs is limited. Our large randomized controlled trial (RCT) demonstrated positive effects of the cognitive rehabilitation program developed by our group. We converted the program into the iPad-based cognitive rehabilitation program ReMind, to increase its accessibility. The app incorporates psychoeducation, strategy training and retraining...
January 10, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29321125/efficacy-of-a-web-based-safety-decision-aid-for-women-experiencing-intimate-partner-violence-randomized-controlled-trial
#19
Jane Koziol-McLain, Alain C Vandal, Denise Wilson, Shyamala Nada-Raja, Terry Dobbs, Christine McLean, Rose Sisk, Karen B Eden, Nancy E Glass
BACKGROUND: Intimate partner violence (IPV) is a human rights violation and leading health burden for women. Safety planning is a hallmark of specialist family violence intervention, yet only a small proportion of women access formal services. A Web-based safety decision aid may reach a wide audience of women experiencing IPV and offer the opportunity to prioritize and plan for safety for themselves and their families. OBJECTIVE: The aim of this study was to test the efficacy of a Web-based safety decision aid (isafe) for women experiencing IPV...
January 10, 2018: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29321046/application-of-causal-inference-methods-in-the-analyses-of-randomised-controlled-trials-a-systematic-review
#20
REVIEW
Ruth E Farmer, Daphne Kounali, A Sarah Walker, Jelena Savović, Alison Richards, Margaret T May, Deborah Ford
BACKGROUND: Applications of causal inference methods to randomised controlled trial (RCT) data have usually focused on adjusting for compliance with the randomised intervention rather than on using RCT data to address other, non-randomised questions. In this paper we review use of causal inference methods to assess the impact of aspects of patient management other than the randomised intervention in RCTs. METHODS: We identified papers that used causal inference methodology in RCT data from Medline, Premedline, Embase, Cochrane Library, and Web of Science from 1986 to September 2014, using a forward citation search of five seminal papers, and a keyword search...
January 10, 2018: Trials
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