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https://www.readbyqxmd.com/read/28719791/effectiveness-of-psychosocial-and-educational-prenatal-and-postnatal-care-interventions-for-married-immigrant-women-in-korea-systematic-review-and-meta-analysis
#1
Sun Kyung Kim, Seyeon Park, Sukhee Ahn
The rapid influx of married immigrant women from low-income Asian countries is a concern in South Korea, Japan, and Taiwan. In South Korea, 1 in 10 couples includes a Korean man and a migrant woman, increasing the need for prenatal and postnatal care interventions. Studies published in English or Korean after 2000 were retrieved from 8 databases and reviewed via a systematic review and meta-analysis of the effectiveness of prenatal and postnatal psychosocial and educational interventions in Korea. Of 3583 records, 10 studies (1 randomized controlled trial [RCT] and 9 non-RCTs) involving 408 married immigrant women fulfilled the inclusion criteria...
July 2017: Asia-Pacific Journal of Public Health
https://www.readbyqxmd.com/read/28718878/deep-brain-and-cortical-stimulation-for-epilepsy
#2
REVIEW
Mathieu Sprengers, Kristl Vonck, Evelien Carrette, Anthony G Marson, Paul Boon
BACKGROUND: Despite optimal medical treatment, including epilepsy surgery, many epilepsy patients have uncontrolled seizures. Since the 1970s interest has grown in invasive intracranial neurostimulation as a treatment for these patients. Intracranial stimulation includes both deep brain stimulation (DBS) (stimulation through depth electrodes) and cortical stimulation (subdural electrodes). This is an updated version of a previous Cochrane review published in 2014. OBJECTIVES: To assess the efficacy, safety and tolerability of DBS and cortical stimulation for refractory epilepsy based on randomized controlled trials (RCTs)...
July 18, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28718356/comparison-of-three-non-invasive-ventilation-strategies-nsippv-bipap-ncpap-for-rds-in-vlbw-infants
#3
Vincenzo Salvo, Gianluca Lista, Enrica Lupo, Alberto Ricotti, Luc J I Zimmermann, Antonio W D Gavilanes, Eloisa Gitto, Micaela Colivicchi, Valeria Ferraù, Diego Gazzolo
BACKGROUND: Noninvasive ventilation (NIV) significantly changed the management of respiratory distress syndrome (RDS) in preterm infants. Further perspectives for neonatologists regard the assessment of different NIV strategies in terms of availability, effectiveness and failure. OBJECTIVE: The aim of the present study is to evaluate the effectiveness of three different NIV strategies: nasal continuous pressure (N-CPAP), nasal synchronized intermittent positive pressure ventilation (N-SIPPV) and nasal bilevel CPAP (BiPAP), as first intention treatment for RDS in very low birth-weight infants (VLBW)...
July 18, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28718248/outcome-of-0-2-glyceryltrinitrate-cream-versus-2-diltiazem-cream-in-the-treatment-of-chronic-anal-fissure
#4
Muhammad Siddique Khan, Ismail Akbar, Junaid Zeb, Salman Ahmad, Ajmal Khan
BACKGROUND: Anal fissure is a linear tear in the distal anal canal resulting from persistent hypertonia and spasm of the internal sphincter which results in mucosal ischemia. We have conducted a study in order to compare the outcome of 0.2% glyceryl trinitrate cream versus 2% diltiazem cream in the treatment of chronic anal fissure. METHODS: This randomized controlled trial (RCT) was carried out in the Department of Surgical "B" unit, at Ayub Teaching Hospital, Abbottabad, Pakistan from 15th June 2012 to 15th May 2015...
April 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28718012/implant-decontamination-with-phosphoric-acid-during-surgical-peri-implantitis-treatment-a-rct
#5
Diederik F M Hentenaar, Yvonne C M De Waal, Hans Strooker, Henny J A Meijer, Arie-Jan Van Winkelhoff, Gerry M Raghoebar
BACKGROUND: Peri-implantitis is known as an infectious disease that affects the peri-implant soft and hard tissue. Today, scientific literature provides very little evidence for an effective intervention protocol for treatment of peri-implantitis. The aim of the present randomized controlled trial is to evaluate the microbiological and clinical effectiveness of phosphoric acid as a decontaminating agent of the implant surface during surgical peri-implantitis treatment. METHODS: Peri-implantitis lesions were treated with resective surgical treatment aimed at peri-implant granulation tissue removal, bone recontouring, and pocket elimination...
December 2017: International Journal of Implant Dentistry
https://www.readbyqxmd.com/read/28717981/effects-of-counselling-on-adherence-to-antiretroviral-treatment-among-people-with-hiv-in-estonia-a-randomized-controlled-trial
#6
Anneli Uusküla, Kaja-Triin Laisaar, Mait Raag, Liis Lemsalu, Liilia Lõhmus, Kristi Rüütel, K Rivet Amico
To assess the efficacy of an education- and strengths-based counselling programme to promote antiretroviral therapy (ART) adherence in a cohort of HIV-infected individuals with high prevalence of injection drug use in Estonia. Parallel-group randomized (1:1) controlled trial (RCT). Adults receiving ART in two clinics were followed for 12 months. The trial compared: (i) an intervention (three sessions) incorporated into routine clinic visits, providing education about HIV, ART, the role of adherence, and tailoring regimen to daily routines using problem-solving skills to address adherence barriers versus (ii) usual care (control)...
July 17, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28717908/systematic-review-and-meta-analysis-of-laparoscopic-versus-open-appendicectomy-in-adults-with-complicated-appendicitis-an-update-of-the-literature
#7
Christos Athanasiou, Sonia Lockwood, Georgios A Markides
AIMS: To review and compare the outcomes of laparoscopic (LA) versus open appendicectomy (OA) in complicated appendicitis in adult patients, eight years after the last literature review. METHODS: The PRISMA guidelines were adhered to. Pre-defined inclusion and exclusion criteria were used to search the PubMed, Scopus and Cochrane databases and extract relevant data. Methodological and quality assessment was undertaken with outcome meta-analysis and subgroup analyses of methodological quality, type of study and year of study...
July 17, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28717616/topical-polidocanol-application-in-combination-with-static-stretching-in-tendinopathies-a-prospective-pilot-study
#8
Matthias Gatz, Simone Schrading, Timm Dirrichs, Marcel Betsch, Markus Tingart, Björn Rath, Christiane Kuhl, Valentin Quack
BACKGROUND: Highly operator-based injection therapy with vasosclerosing and anesthetic polidocanol is used for tendinopathies. This pilot-study evaluates the topical application of polidocanol gel. METHODS: Prospective case series. 39 patients with tendinopathies (14 Achilles, 14 patella, 11 wrist extensors) with a symptom duration > 6 months were included. Polidocanol and static stretching were the therapy in the first 2 weeks, while static stretching was continuously performed for 6 months...
January 2017: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/28715852/treatment-of-premenstrual-dysphoria-with-continuous-versus-intermittent-dosing-of-oral-contraceptives-results-of-a-three-arm-randomized-controlled-trial
#9
Tory A Eisenlohr-Moul, Susan S Girdler, Jacqueline L Johnson, Peter J Schmidt, David R Rubinow
BACKGROUND: Although traditionally dosed combined oral contraceptives (COCs) (21 days of active pills, 7 days of inactive pills) have not been demonstrated as superior to placebo for the treatment of premenstrual dysphoria (PMD), some randomized controlled trials (RCTs) indicate that oral contraceptives administered with a shortened or eliminated hormone-free interval are superior to placebo. However, results of such trials are mixed, and no existing studies have directly compared continuous and intermittent dosing schedules of the same oral contraceptive...
July 17, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/28715577/device-safety-implications-of-the-clinical-data-leading-to-us-food-and-drug-administration-approval-of-soft-tissue-fillers-a-systematic-review
#10
Mary E Lohman, Comeron W Ghobadi, Shuai Xu
Importance: The US Food and Drug Administration (FDA) recently issued a safety warning regarding soft-tissue fillers (STFs) based on the risk of blindness and facial necrosis. Objective: To examine the quality of evidence leading to FDA approval of STFs. Evidence Review: All original approvals for STFs were mined using the publicly available FDA database. The Cochrane Collaboration's risk of bias assessment tool was applied to all randomized clinical trials (RCTs)...
July 13, 2017: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/28714762/effectiveness-of-prp-injection-in-reducing-recovery-time-of-acute-hamstring-injury-a-critically-appraised-topic
#11
Mary Lynn Manduca, Stephen J Straub
Clinical Scenario Hamstring strains are common athletic injuries, with a high recurrence rate (34%).(2) Recently, platelet-rich-plasma (PRP) injections have gained popularity as a potential treatment option to accelerate healing of hamstring injury.(3) Focused Clinical Question Does the combination of PRP injection and rehabilitation decrease recovery time of acute hamstring injury as compared to rehabilitation alone in collegiate athletes? Summary of Key Findings A literature search resulted in three randomized controlled trials (RCT)...
July 17, 2017: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/28712965/trial-exclusion-criteria-and-their-impact-on-the-estimation-of-antipsychotic-drugs-effect-a-case-study-using-the-soho-database
#12
Clementine Nordon, Thomas Bovagnet, Mark Belger, Javier Jimenez, Robert Olivares, Helene Chevrou-Severac, Helene Verdoux, Josep Maria Haro, Lucien Abenhaim, Helene Karcher
OBJECTIVES: To explore the impact upon estimation of drug effect as a result of applying exclusion criteria in randomized-controlled trials (RCT) measuring the efficacy of antipsychotics (AP) in schizophrenia. METHODS: Three characteristics which may act as effect-modifiers of AP, while also common exclusion criteria in RCTs, were identified through literature review: schizophrenia duration, substance use disorder and poor adherence. The SOHO cohort was used to estimate the effect of initiating antipsychotic drugs "A", "B" or "C" (pooled) upon symptom evolution at 3months from baseline (CGI-S scale)...
July 13, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28712615/predicting-real-world-effectiveness-of-cancer-therapies-using-overall-survival-and-progression-free-survival-from-clinical-trials-empirical-evidence-for-the-asco-value-framework
#13
Darius N Lakdawalla, Jason Shafrin, Ningqi Hou, Desi Peneva, Seanna Vine, Jinhee Park, Jie Zhang, Ron Brookmeyer, Robert A Figlin
OBJECTIVES: To measure the relationship between randomized controlled trial (RCT) efficacy and real-world effectiveness for oncology treatments as well as how this relationship varies depending on an RCT's use of surrogate versus overall survival (OS) endpoints. METHODS: We abstracted treatment efficacy measures from 21 phase III RCTs reporting OS and either progression-free survival or time to progression endpoints in breast, colorectal, lung, ovarian, and pancreatic cancers...
July 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/28711556/medicine-based-evidence-for-individualized-decision-making-case-study-of-systemic-lupus-erythematosis
#14
Ashley E Wivel, Kate Lapane, Christi Kleoudis, Burton H Singer, Ralph I Horwitz
To guide management decisions of an index patient evidence is required from comparisons between approximate matches to the profile of the index case, where some matches contain responses to treatment and others act as controls. We describe a method for constructing clinically relevant histories/profiles using data collected but unreported from two recent phase 3 RCTs assessing belimumab in subjects with clinically active and serologically positive SLE. Outcomes were the SRI (SLE Responder Index) measured at 52 weeks...
July 12, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28710289/nutritional-modulation-of-metabolic-inflammation
#15
REVIEW
Anna M Kirwan, Yvonne M Lenighan, Marcella E O'Reilly, Fiona C McGillicuddy, Helen M Roche
Metabolic inflammation is a very topical area of research, wherein aberrations in metabolic and inflammatory pathways probably contribute to atherosclerosis, insulin resistance (IR) and type 2 diabetes. Metabolic insults arising from obesity promote inflammation, which in turn impedes insulin signalling and reverse cholesterol transport (RCT). Key cells in the process are metabolically activated macrophages, which up-regulate both pro- and anti-inflammatory pathways in response to lipid spillover from adipocytes...
July 14, 2017: Biochemical Society Transactions
https://www.readbyqxmd.com/read/28710229/pirate-project-point-of-care-informatics-based-randomised-controlled-trial-for-decreasing-overuse-of-antibiotic-therapy-in-gram-negative-bacteraemia
#16
Angela Huttner, Werner C Albrich, Pierre-Yves Bochud, Angèle Gayet-Ageron, Anne Rossel, Elodie von Dach, Stephan Harbarth, Laurent Kaiser
INTRODUCTION: Antibiotic overuse drives antibiotic resistance. The optimal duration of antibiotic therapy for Gram-negative bacteraemia (GNB), a common community and hospital-associated infection, remains unknown and unstudied via randomised controlled trials (RCTs). METHODS AND ANALYSIS: This investigator-initiated, multicentre, non-inferiority, informatics-based point-of-care RCT will randomly assign adult hospitalised patients receiving microbiologically efficacious antibiotic(s) for GNB to (1) 14 days of antibiotic therapy, (2) 7 days of therapy or (3) an individualised duration determined by clinical response and 75% reduction in peak C reactive protein (CRP) values...
July 13, 2017: BMJ Open
https://www.readbyqxmd.com/read/28710065/the-limitations-of-using-randomised-controlled-trials-as-a-basis-for-developing-treatment-guidelines
#17
REVIEW
Roger Mulder, Ajeet B Singh, Amber Hamilton, Pritha Das, Tim Outhred, Grace Morris, Darryl Bassett, Bernhard T Baune, Michael Berk, Philip Boyce, Bill Lyndon, Gordon Parker, Gin S Malhi
Randomised controlled trials (RCTs) are considered the 'gold standard' by which novel psychotropic medications and psychological interventions are evaluated and consequently adopted into widespread clinical practice. However, there are some limitations to using RCTs as the basis for developing treatment guidelines. While RCTs allow researchers to determine whether a given medication or intervention is effective in a specific patient sample, for practicing clinicians it is more important to know whether it will work for their particular patient in their particular setting...
July 14, 2017: Evidence-based Mental Health
https://www.readbyqxmd.com/read/28709470/the-effects-of-cognitive-bias-modification-training-and-oxytocin-administration-on-trust-in-maternal-support-study-protocol-for-a-randomized-controlled-trial
#18
Martine W F T Verhees, Eva Ceulemans, Marian J Bakermans-Kranenburg, Marinus H van IJzendoorn, Simon de Winter, Guy Bosmans
BACKGROUND: Lack of trust in parental support is a transdiagnostic risk factor for the development of psychological problems throughout the lifespan. Research suggests that children's cognitive attachment representations and related information processing biases could be an important target for interventions aiming to build trust in the parent-child relationship. A paradigm that can alter these biases and increase trust is that of Cognitive Bias Modification (CBM), during which a target processing bias is systematically trained...
July 14, 2017: Trials
https://www.readbyqxmd.com/read/28708838/decreasing-rates-of-disorganised-attachment-in-infants-and-young-children-who-are-at-risk-of-developing-or-who-already-have-disorganised-attachment-a-systematic-review-and-meta-analysis-of-early-parenting-interventions
#19
Barry Wright, Lisa Hackney, Ellen Hughes, Melissa Barry, Danya Glaser, Vivien Prior, Victoria Allgar, David Marshall, Jamie Barrow, Natalie Kirby, Megan Garside, Pulkit Kaushal, Amanda Perry, Dean McMillan
BACKGROUND: Disorganised attachment patterns in infants have been linked to later psychopathology. Services have variable practices for identifying and providing interventions for families of children with disorganised attachment patterns, which is the attachment pattern leading to most future psychopathology. Several recent government reports have highlighted the need for better parenting interventions in at risk groups. OBJECTIVES: The objective of this review and meta-analysis was to evaluate the clinical effectiveness of available parenting interventions for families of children at high risk of developing, or already showing, a disorganised pattern of attachment...
2017: PloS One
https://www.readbyqxmd.com/read/28708766/is-the-rationale-more-important-than-deception-a-randomized-controlled-trial-of-openlabel-placebo-analgesia
#20
Cosima Locher, Antje Frey Nascimento, Irving Kirsch, Joe Kossowsky, Andrea Meyer, Jens Gaab
Research on open-label placebos questions whether deception is a necessary characteristic of placebo effects. Yet, comparisons between open-label and deceptive placebos are lacking. We therefore assessed effects of open-label and deceptive placebos in comparison to no treatment with a standardized experimental heat pain paradigm in a RCT in healthy participants. Participants (N = 160) were randomly assigned to no treatment (NT), open-label placebo without rationale (OPR-), open-label placebo with rationale (OPR+) and deceptive placebo (DP)...
July 12, 2017: Pain
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