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https://www.readbyqxmd.com/read/28105467/mapt-association-with-rem-sleep-behavior-disorder
#1
Rubén Fernández-Santiago, Alex Iranzo, Carles Gaig, Mónica Serradell, Manel Fernández, Pau Pastor, Eduardo Tolosa, Joan Santamaría, Mario Ezquerra
No abstract text is available yet for this article.
February 2017: Neurology. Genetics
https://www.readbyqxmd.com/read/28099555/modulation-of-the-ultradian-human-nasal-cycle-by-sleep-stage-and-body-position
#2
Richard E Frye, Deborah F Rosin, Adrian R Morrison, Fidias E Leon-Sarmiento, Richard L Doty
Objective: The nasal cycle, which is present in a significant number of people, is an ultradian side-to-side rhythm of nasal engorgement associated with cyclic autonomic activity. We studied the nasal cycle during REM/non-REM sleep stages and examined the potentially confounding influence of body position on lateralized nasal airflow. Methods: Left- and right-side nasal airflow was measured in six subjects during an eight-hour sleep period using nasal thermistors...
January 2017: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/28093795/the-natural-history-of-pure-autonomic-failure-a-u-s-prospective-cohort
#3
Horacio Kaufmann, Lucy Norcliffe-Kaufmann, Jose-Alberto Palma, Italo Biaggioni, Phillip A Low, Wolfgang Singer, David S Goldstein, Amanda C Peltier, Cyndia A Shibao, Christopher H Gibbons, Roy Freeman, David Robertson
OBJECTIVE: To define the clinical features and biomarkers that predict which patients with pure autonomic failure will develop Parkinson disease, dementia with Lewy bodies, or multiple system atrophy. METHODS: One hundred patients who presented with pure autonomic failure were recruited at 5 medical centers in the U.S. Seventy-four patients agreed to be followed prospectively. Patients underwent clinical evaluations including neurological rating scales, sleep questionnaires, smell test, and sympathetic and parasympathetic cardiovascular autonomic function tests...
January 17, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28092659/rem-sleep-selectively-prunes-and-maintains-new-synapses-in-development-and-learning
#4
Wei Li, Lei Ma, Guang Yang, Wen-Biao Gan
The functions and underlying mechanisms of rapid eye movement (REM) sleep remain unclear. Here we show that REM sleep prunes newly formed postsynaptic dendritic spines of layer 5 pyramidal neurons in the mouse motor cortex during development and motor learning. This REM sleep-dependent elimination of new spines facilitates subsequent spine formation during development and when a new motor task is learned, indicating a role for REM sleep in pruning to balance the number of new spines formed over time. Moreover, REM sleep also strengthens and maintains newly formed spines, which are critical for neuronal circuit development and behavioral improvement after learning...
January 16, 2017: Nature Neuroscience
https://www.readbyqxmd.com/read/28092583/deep-learning-and-insomnia-assisting-clinicians-with-their-diagnosis
#5
Mostafa Shahin, Beena Ahmed, Sana Tmar-Ben Hamida, Fathima Mulaffer, Martin Glos, Thomas Penzel
Effective sleep analysis is hampered by the lack of automated tools catering for disordered sleep patterns and cumbersome monitoring hardware. In this paper, we apply deep learning on a set of 57 EEG features extracted from a maximum of two EEG channels to accurately differentiate between patients with insomnia or controls with no sleep complaints. We investigated two different approaches to achieve this. The first approach used EEG data from the whole sleep recording irrespective of the sleep stage (stage-independent classification), while the second used only EEG data from insomnia-impacted specific sleep stages (stage-dependent classification)...
January 9, 2017: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28091622/clinical-variations-in-parkinson-s-disease-patients-with-or-without-rem-sleep-behaviour-disorder-a-meta-analysis
#6
Ruo-Lin Zhu, Cheng-Juan Xie, Pan-Pan Hu, Kai Wang
This study aimed to evaluate the clinical variations in patients with Parkinson's disease (PD) with (PDRBD) or without REM sleep behaviour disorder (RBD) (Non-RBD), and PDRBD patients were classified into Confirmed-RBD (definite diagnosis with polysomnography, PSG) and Probable-RBD (without PSG re-confirmation). The clinical difference between the groups of patients was measured as an odds ratio (OR) or standardized mean difference (SMD, Cohen d). A total of 31 articles with data from 5,785 participants were obtained for our analysis...
January 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28088873/developmental-changes-in-ultradian-sleep-cycles-across-early-childhood
#7
Sean Lopp, William Navidi, Peter Achermann, Monique LeBourgeois, Cecilia Diniz Behn
Nocturnal human sleep is composed of cycles between rapid eye movement (REM) sleep and non-REM (NREM) sleep. In adults, the structure of ultradian cycles between NREM and REM sleep is well characterized; however, less is known about the developmental trajectories of ultradian sleep cycles across early childhood. Cross-sectional studies indicate that the rapid ultradian cycling of active-quiet sleep in infancy shifts to a more adult-like pattern of NREM-REM sleep cycling by the school-age years, yet longitudinal studies elucidating the details of this transition are scarce...
January 1, 2017: Journal of Biological Rhythms
https://www.readbyqxmd.com/read/28087252/novel-method-for-evaluation-of-eye-movements-in-patients-with-narcolepsy
#8
Julie A E Christensen, Lykke Kempfner, Helle L Leonthin, Mathias Hvidtfelt, Miki Nikolic, Birgitte Rahbek Kornum, Poul Jennum
BACKGROUND: Narcolepsy causes abnormalities in the control of wake-sleep, non-rapid-eye-movement (non-REM) sleep and REM sleep, which inlcudes specific eye movements (EMs). In this study, we aim to evaluate EM characteristics in narcolepsy as compared to controls using an automated detector. METHODS: We developed a data-driven method to detect EMs during sleep based on two EOG signals recorded as part of a polysomnography (PSG). The method was optimized using the manually scored hypnograms from 36 control subjects...
December 21, 2016: Sleep Medicine
https://www.readbyqxmd.com/read/28077261/ventral-medullary-control-of-rapid-eye-movement-sleep-and-atonia
#9
Michael C Chen, Ramalingam Vetrivelan, Chun-Ni Guo, Catie Chang, Patrick M Fuller, Jun Lu
Discrete populations of neurons at multiple levels of the brainstem control rapid eye movement (REM) sleep and the accompanying loss of postural muscle tone, or atonia. The specific contributions of these brainstem cell populations to REM sleep control remains incompletely understood. Here we show in rats that viral vector-based lesions of the ventromedial medulla at a level rostral to the inferior olive (pSOM) produced violent myoclonic twitches and abnormal electromyographic spikes, but not complete loss of tonic atonia, during REM sleep...
January 7, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28070566/interleukin-37-expression-in-mice-alters-sleep-responses-to-inflammatory-agents-and-influenza-virus-infection
#10
Christopher J Davis, Mark R Zielinski, Danielle Dunbrasky, Ping Taishi, Charles A Dinarello, James M Krueger
Multiple interactions between the immune system and sleep are known, including the effects of microbial challenge on sleep or the effects of sleep loss on facets of the immune response. Cytokines regulate, in part, sleep and immune responses. Here we examine the role of an anti-inflammatory cytokine, interleukin-37 (IL-37) on sleep in a mouse strain that expresses human IL-37b (IL37tg mice). Constitutive expression of the IL-37 gene in the brains of these mice under resting conditions is low; however, upon an inflammatory stimulus, expression increases dramatically...
June 2017: Neurobiology of Sleep and Circadian Rhythms
https://www.readbyqxmd.com/read/28066138/potentiation-of-decursinol-angelate-on-pentobarbital-induced-sleeping-behaviors-via-the-activation-of-gabaa-ergic-systems-in-rodents
#11
Jae Hoon Woo, Tae-Woo Ha, Jae-Seon Kang, Jin Tae Hong, Ki-Wan Oh
Angelicae Gigantis Radix (AGR, Angelica gigas) has been used for a long time as a traditional folk medicine in Korea and oriental countries. Decursinol angelate (DCA) is structurally isomeric decursin, one of the major components of AGR. This study was performed to confirm whether DCA augments pentobarbital-induced sleeping behaviors via the activation of GABAA-ergic systems in animals. Oral administration of DCA (10, 25 and 50 mg/kg) markedly suppressed spontaneous locomotor activity. DCA also prolonged sleeping time, and decreased the sleep latency by pentobarbital (42 mg/kg), in a dose-dependent manner, similar to muscimol, both at the hypnotic (42 mg/kg) and sub-hypnotic (28 mg/kg) dosages...
January 2017: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/28061506/role-of-rem-sleep-melanin-concentrating-hormone-and-orexin-hypocretin-systems-in-the-sleep-deprivation-pre-ischemia
#12
Marta Pace, Antoine Adamantidis, Laura Facchin, Claudio Bassetti
STUDY OBJECTIVES: Sleep reduction after stroke is linked to poor recovery in patients. Conversely, a neuroprotective effect is observed in animals subjected to acute sleep deprivation (SD) before ischemia. This neuroprotection is associated with an increase of the sleep, melanin concentrating hormone (MCH) and orexin/hypocretin (OX) systems. This study aims to 1) assess the relationship between sleep and recovery; 2) test the association between MCH and OX systems with the pathological mechanisms of stroke...
2017: PloS One
https://www.readbyqxmd.com/read/28060294/manipulation-of-epileptiform-electrocorticograms-ecogs-and-sleep-in-rats-and-mice-by-acupuncture
#13
Pei-Lu Yi, Shuo-Bin Jou, Yi-Jou Wu, Fang-Chia Chang
Ancient Chinese literature has documented that acupuncture possesses efficient therapeutic effects on epilepsy and insomnia. There is, however, little research to reveal the possible mechanisms behind these effects. To investigate the effect of acupuncture on epilepsy and sleep, several issues need to be addressed. The first is to identify the acupoints, which correspond between humans, rats, and mice. Furthermore, the depth of insertion of the acupuncture needle, the degree of needle twist in manual needle acupuncture, and the stimulation parameters for electroacupuncture (EA) need to be determined...
December 22, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28043770/sleep-related-modifications-of-eeg-connectivity-in-the-sensory-motor-networks-in-huntington-disease-an-eloreta-study-and-review-of-the-literature
#14
Carla Piano, Claudio Imperatori, Anna Losurdo, Anna Rita Bentivoglio, Pietro Cortelli, Giacomo Della Marca
OBJECTIVE: To evaluate EEG functional connectivity in the sensory-motor network, during wake and sleep, in patients with Huntington Disease (HD). METHODS: 23 patients with HD and 23 age- and sex-matched healthy controls were enrolled. EEG connectivity analysis was performed by means of exact Low Resolution Electric Tomography (eLORETA). RESULTS: In wake, HD patients showed an increase of delta lagged phase synchronization (T=3.60; p<0.05) among Broadman's Areas (BA) 6-8 bilaterally; right BA 6-8 and right BA 1-2-3; left BA 1-2-3 and left BA 4...
December 5, 2016: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28041664/early-gene-activation-initiates-neuroinflammation-prior-to-vsv-neuroinvasion-impact-on-antiviral-responses-and-sleep
#15
Richard P Ciavarra, Patric Lundberg, Mayumi Machida, Marta A Ambrozewicz, Laurie L Wellman, Kimberly Breving, Christina Steel, Larry D Sanford
Rapid eye movement (REM) sleep is rapidly and persistently suppressed during vesicular stomatitis virus (VSV) encephalitis in C57Bl/6J (B6) mice. REM sleep suppression was associated with a complex global brain chemokine/cytokine response with bimodal kinetics although regionally distinct cytokine profiles were readily identified. Cytokine mRNA was translated either immediately or suppressed until the pathogen was cleared from the CNS. Innate signaling pathway (TLRs, RIG-I) activation occurred rapidly and sequentially prior to VSV neuroinvasion suggesting that antiviral states are quickly established in the CNS in advance of viral pathogen penetration...
December 29, 2016: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/28039375/cholinergic-glutamatergic-and-gabaergic-neurons-of-the-ppt-have-distinct-effects-on-sleep-wake-behavior-in-mice
#16
Daniel Kroeger, Loris L Ferrari, Gaetan Petit, Carrie E Mahoney, Patrick M Fuller, Elda Arrigoni, Thomas E Scammell
: The pedunculopontine tegmental nucleus (PPT) has long been implicated in the regulation of cortical activity and behavioral states, including rapid eye movement (REM) sleep. For example, electrical stimulation of the PPT region during sleep leads to rapid awakening, whereas lesions of the PPT in cats reduce REM sleep. Though these effects have been linked with the activity of cholinergic PPT neurons, the PPT also includes intermingled glutamatergic and GABAergic cell populations, and the precise roles of cholinergic, glutamatergic and GABAergic PPT cell groups in regulating cortical activity and behavioral state remains unknown...
December 30, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28039311/sleep-characteristics-and-cognitive-impairment-in-the-general-population-the-hypnolaus-study
#17
José Haba-Rubio, Helena Marti-Soler, Nadia Tobback, Daniela Andries, Pedro Marques-Vidal, Gérard Waeber, Peter Vollenweider, Armin von Gunten, Martin Preisig, Enrique Castelao, Mehdi Tafti, Raphaël Heinzer, Julius Popp
OBJECTIVE: To assess the association between sleep structure and cognitive impairment in the general population. METHODS: Data stemmed from 580 participants aged >65 years of the population-based CoLaus/PsyCoLaus study (Lausanne, Switzerland) who underwent complete sleep evaluation (HypnoLaus). Evaluations included demographic characteristics, personal and treatment history, sleep complaints and habits (using validated questionnaires), and a complete polysomnography at home...
December 30, 2016: Neurology
https://www.readbyqxmd.com/read/28027399/activation-of-bdnf-trkb-signaling-in-the-pedunculopontine-tegmental-nucleus-ppt-a-novel-mechanism-for-the-homeostatic-regulation-of-rem-sleep
#18
Abigail K Barnes, Richa Koul-Tiwari, Jennifer M Garner, Phillip A Geist, Subimal Datta
REM sleep dysregulation is a symptom of many neuropsychiatric disorders, yet the mechanisms of REM sleep homeostatic regulation are not fully understood. We have shown that, after REM sleep deprivation, the pedunculopontine tegmental nucleus (PPT) plays a critical role in the generation of recovery REM sleep. In the present study, we used multidisciplinary techniques to show a causal relationship between BDNF-TrkB signaling in the PPT and the development of REM sleep homeostatic drive. Rats were randomly assigned to conditions of unrestricted sleep or selective REM sleep deprivation (RSD) with PPT microinjections of vehicle control or a dose of a TrkB receptor inhibitor (2, 3, or 4 nmol K252a or 4 nmol ANA-12)...
December 27, 2016: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28019041/interindividual-differences-in-the-dynamics-of-the-homeostatic-process-are-trait-like-and-distinct-for-sleep-versus-wakefulness
#19
Thomas Rusterholz, Leila Tarokh, Hans P A Van Dongen, Peter Achermann
The sleep homeostatic Process S reflects the build-up of sleep pressure during waking and its dissipation during sleep. Process S is modelled as a saturating exponential function during waking and a decreasing exponential function during sleep. Slow wave activity is a physiological marker for non-rapid eye movement (non-REM) sleep intensity and serves as an index of Process S. There is considerable interindividual variability in the sleep homeostatic responses to sleep and sleep deprivation. The aim of this study was to investigate whether interindividual differences in Process S are trait-like...
December 26, 2016: Journal of Sleep Research
https://www.readbyqxmd.com/read/28017595/brain-prolactin-is-involved-in-stress-induced-rem-sleep-rebound
#20
Ricardo Borges Machado, Murilo Ramos Rocha, Deborah Suchecki
REM sleep rebound is a common behavioural response to some stressors and represents an adaptive coping strategy. Animals submitted to multiple, intermittent, footshock stress (FS) sessions during 96h of REM sleep deprivation (REMSD) display increased REM sleep rebound (when compared to the only REMSD ones, without FS), which is correlated to high plasma prolactin levels. To investigate whether brain prolactin plays a role in stress-induced REM sleep rebound two experiments were carried out. In experiment 1, rats were either not sleep-deprived (NSD) or submitted to 96h of REMSD associated or not to FS and brains were evaluated for PRL immunoreactivity (PRL-ir) and determination of PRL concentrations in the lateral hypothalamus and dorsal raphe nucleus...
December 23, 2016: Hormones and Behavior
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