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https://www.readbyqxmd.com/read/28231463/neural-circuitry-of-wakefulness-and-sleep
#1
REVIEW
Thomas E Scammell, Elda Arrigoni, Jonathan O Lipton
Sleep remains one of the most mysterious yet ubiquitous animal behaviors. We review current perspectives on the neural systems that regulate sleep/wake states in mammals and the circadian mechanisms that control their timing. We also outline key models for the regulation of rapid eye movement (REM) sleep and non-REM sleep, how mutual inhibition between specific pathways gives rise to these distinct states, and how dysfunction in these circuits can give rise to sleep disorders.
February 22, 2017: Neuron
https://www.readbyqxmd.com/read/28229031/characterization-of-sleep-architecture-in-down-syndrome-patients-pre-and-post-airway-surgery
#2
Mark Mims, Prasad John Thottam, Dennis Kitsko, Amber Shaffer, Sukgi Choi
OBJECTIVES: To define obstructive sleep architecture patterns in Down syndrome (DS) children as well as changes to sleep architecture patterns postoperatively. STUDY DESIGN: The study was a retrospective review. METHODS: Forty-five pediatric DS patients who underwent airway surgery between 2003 and 2014 at a tertiary children's hospital for obstructive sleep apnea (OSA) were investigated. Postoperative changes in respiratory parameters and sleep architecture (SA) were assessed and compared to general pediatric normative data using paired t-tests and Wilcoxon signed-rank test...
January 17, 2017: Curēus
https://www.readbyqxmd.com/read/28228742/sleep-dependent-consolidation-of-rewarded-behavior-is-diminished-in-children-with-attention-deficit-hyperactivity-disorder-and-a-comorbid-disorder-of-social-behavior
#3
Christian D Wiesner, Ina Molzow, Alexander Prehn-Kristensen, Lioba Baving
Children suffering from attention-deficit hyperactivity disorder (ADHD) often also display impaired learning and memory. Previous research has documented aberrant reward processing in ADHD as well as impaired sleep-dependent consolidation of declarative memory. We investigated whether sleep also fosters the consolidation of behavior learned by probabilistic reward and whether ADHD patients with a comorbid disorder of social behavior show deficits in this memory domain, too. A group of 17 ADHD patients with comorbid disorders of social behavior aged 8-12 years and healthy controls matched for age, IQ, and handedness took part in the experiment...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28227982/analysis-of-the-sleep-eeg-in-the-complexity-domain
#4
Sara Mariani, Ana F T Borges, Teresa Henriques, Robert J Thomas, Samuel J Leistedt, Paul Linkowski, Jean-Pol Lanquart, Ary L Goldberger, Madalena D Costa, Sara Mariani, Ana F T Borges, Teresa Henriques, Robert J Thomas, Samuel J Leistedt, Paul Linkowski, Jean-Pol Lanquart, Ary L Goldberger, Madalena D Costa, Teresa Henriques, Robert J Thomas, Madalena D Costa, Samuel J Leistedt, Paul Linkowski, Ary L Goldberger, Jean-Pol Lanquart, Sara Mariani, Ana F T Borges
Conventional sleep analysis relies primarily on electroencephalogram (EEG) waveform features assessed in concert with eye movements, respiration and muscle tone. We explore a complementary "complexity domain" approach based on multiscale entropy (MSE) analysis of EEG signals and discuss its relationships to standard sleep analysis and to that based on electrocardiogram (ECG)-derived cardiopulmonary coupling (CPC). We observe a progressive decrease in complexity associated with decreased arousability, as measured by both conventional sleep scoring and CPC analysis...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227613/sleep-stage-classification-by-non-contact-vital-signs-indices-using-doppler-radar-sensors
#5
Masayuki Kagawa, Kazuki Suzumura, Takemi Matsui, Masayuki Kagawa, Kazuki Suzumura, Takemi Matsui, Kazuki Suzumura, Takemi Matsui, Masayuki Kagawa
Disturbed sleep has become more common in recent years. To improve the quality of sleep, undergoing sleep observation has gained interest as a means to resolve possible problems. In this paper, we evaluate a non-restrictive and non-contact method for classifying real-time sleep stages and report on its potential applications. The proposed system measures heart rate (HR), heart rate variability (HRV), body movements, and respiratory signals of a sleeping person using two 24-GHz microwave radars placed beneath the mattress...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227264/sleep-architecture-measurement-based-on-cardiorespiratory-parameters
#6
Alexander Tataraidze, Lyudmila Korostovtseva, Lesya Anishchenko, Mikhail Bochkarev, Yurii Sviryaev, Alexander Tataraidze, Lyudmila Korostovtseva, Lesya Anishchenko, Mikhail Bochkarev, Yurii Sviryaev, Mikhail Bochkarev, Yurii Sviryaev, Lesya Anishchenko, Lyudmila Korostovtseva, Alexander Tataraidze
This paper presents a method for the detection of wakeful state, rapid eye movement sleep (REM), light sleep (N1&N2) and deep sleep (N3&N4) based on cardiorespiratory parameters. Experiments were conducted with data of 625 subjects without sleep-disordered breathing selected from the SHHS dataset. Compared to previous studies, our method considers results of neighboring epochs classification and epoch position over record time. The method demonstrates Cohen's kappa of 0.57 ± 0.13 and the accuracy of 71.4 ± 8...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227191/application-of-independent-component-analysis-to-remove-linear-dependencies-in-eeg-recorded-in-hippocampus
#7
J Harry Blaise, Taikang Ning, J Harry Blaise, Taikang Ning, Taikang Ning
Linear cross-spectral and nonlinear cross-bispectral analysis techniques were applied to EEG data recorded simultaneously in two subfields (CA1 and dentate gyrus) of the hippocampus in freely behaving neonatal rats during REM sleep. Linear dependencies between the two sites were specifically removed using independent component analysis (ICA). The cross-spectrum and the cross-bispectrum computed prior to ICA processing were compared with those after ICA processing to determine its effects. Our results indicate that ICA almost completely extracts the linear relationship in the theta frequency band between CA1 and the dentate gyrus...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227113/developmental-differences-of-dimension-complexity-of-hippocampal-eeg-during-rem-sleep
#8
Taikang Ning, J Harry Blaise, Mariam Avagyan, Prawesh Dahal, Taikang Ning, J Harry Blaise, Mariam Avagyan, Prawesh Dahal, J Harry Blaise, Taikang Ning, Mariam Avagyan, Prawesh Dahal
This paper uses spectral analysis and correlation dimension index to examine the developmental differences between the EEG measured from two hippocampal subfields, CA1 and the dentate gyrus. The study was focused on the hippocampal EEG during the vigilance state of REM sleep in freely moving rats of 15 and 90 days of age. Power spectra, magnitude-squared coherence, and correlation dimension were estimated. The correlation dimension adds a new interpretation from the nonlinear dynamics perspective, and we found that there are no significant developmental differences between the granule cells of the dentate gyrus and the pyramidal cells of area CA1 when the theta activity was present during REM sleep...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227112/estimation-of-macro-sleep-stages-from-whole-night-audio-analysis
#9
E Dafna, M Halevi, D Ben Or, A Tarasiuk, Y Zigel, E Dafna, M Halevi, D Ben Or, A Tarasiuk, Y Zigel, D Ben Or, Y Zigel, M Halevi, E Dafna, A Tarasiuk
During routine sleep diagnostic procedure, sleep is broadly divided into three states: rapid eye movement (REM), non-REM (NREM) states, and wake, frequently named macro-sleep stages (MSS). In this study, we present a pioneering attempt for MSS detection using full night audio analysis. Our working hypothesis is that there might be differences in sound properties within each MSS due to breathing efforts (or snores) and body movements in bed. In this study, audio signals of 35 patients referred to a sleep laboratory were recorded and analyzed...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227111/sleep-stage-recognition-using-respiration-signal
#10
Jialei Yang, James M Keller, Mihail Popescu, Marjorie Skubic, Jialei Yang, James M Keller, Mihail Popescu, Marjorie Skubic, James M Keller, Mihail Popescu, Marjorie Skubic, Jialei Yang
This paper presents a sleep stage recognition system for Awake, rapid eye movement (REM) and non-REM (NREM) sleep detection. Two respiratory variability (RV) features are extracted from oro-nasal airflow signals provided in the sleep-EDF (Expanded) database. A two layer system with threshold comparison classifier is implemented. This system achieved state-of-the-art performance with simple features and classifiers. The average accuracy of 74.00%±5.30% and Cohen's kappa coefficient of 0.49±0.08 were achieved with 21 recordings...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227110/bioradiolocation-based-sleep-stage-classification
#11
Alexander Tataraidze, Lyudmila Korostovtseva, Lesya Anishchenko, Mikhail Bochkarev, Yurii Sviryaev, Sergey Ivashov, Alexander Tataraidze, Lyudmila Korostovtseva, Lesya Anishchenko, Mikhail Bochkarev, Yurii Sviryaev, Sergey Ivashov, Mikhail Bochkarev, Yurii Sviryaev, Lesya Anishchenko, Lyudmila Korostovtseva, Sergey Ivashov, Alexander Tataraidze
This paper presents a method for classifying wakefulness, REM, light and deep sleep based on the analysis of respiratory activity and body motions acquired by a bioradar. The method was validated using data of 32 subjects without sleep-disordered breathing, who underwent a polysomnography study in a sleep laboratory. We achieved Cohen's kappa of 0.49 in the wake-REM-light-deep sleep classification, 0.55 for the wake-REM-NREM classification and 0.57 for the sleep/wakefulness determination. The results might be useful for the development of unobtrusive sleep monitoring systems for diagnostics, prevention, and management of sleep disorders...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226824/tunable-somatosensory-stimulation-for-selective-sleep-restriction-studies-in-rodents
#12
Dillon M Huffman, Kendra E Staggs, Farid Yaghouby, Anuj Agarwal, Bruce F O'Hara, Kevin D Donohue, Eric M Blalock, Sridhar Sunderam, Dillon M Huffman, Kendra E Staggs, Farid Yaghouby, Anuj Agarwal, Bruce F O'Hara, Kevin D Donohue, Eric M Blalock, Sridhar Sunderam, Eric M Blalock, Bruce F O'Hara, Kevin D Donohue, Kendra E Staggs, Sridhar Sunderam, Anuj Agarwal, Dillon M Huffman, Farid Yaghouby
Many methods for sleep restriction in rodents have emerged, but most are intrusive, lack fine control, and induce stress. Therefore, a versatile, non-intrusive means of sleep restriction that can alter sleep in a controlled manner could be of great value in sleep research. In previous work, we proposed a novel system for closed-loop somatosensory stimulation based on mechanical vibration and applied it to the task of restricting Rapid Eye Movement (REM) sleep in mice [1]. While this system was effective, it was a crude prototype and did not allow precise control over the amplitude and frequency of stimulation applied to the animal...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226697/differences-in-white-matter-microstructure-between-parkinson-s-disease-patients-with-and-without-rem-sleep-behavior-disorder
#13
Farzaneh Rahmani, Mina Ansari, Atefeh Pooyan, Mehdi M Mirbagheri, Mohammad Hadi Aarabi, Farzaneh Rahmani, Mina Ansari, Atefeh Pooyan, Mehdi M Mirbagheri, Mohammad Hadi Aarabi, Mehdi M Mirbagheri, Farzaneh Rahmani, Atefeh Pooyan, Mina Ansari, Mohammad Hadi Aarabi
REM sleep behavior disorder (RBD) is characterized by increased muscle tone and violent limb movements and usually occurs during the early stages of Parkinson disease (PD). PD patients with RBD represent faster motor progression and cognitive dysfunction. We used diffusion imaging to assess which regions are involved in this phenomenon. In the current study, we computed Quantitative Anisotropic (QA), which is based on spin distribution function (SDF) that quantifies the density of diffusing water and is more sensitive to psychological differences between groups and also diffusion MRI connectometry to conduct group analysis between age and gender matched PD patients with and without RBD...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28224280/predictors-of-success-in-combination-of-tongue-base-resection-and-lateral-pharyngoplasty-for-obstructive-sleep-apnea
#14
Chi Sang Hwang, Jin Won Kim, Sang Chul Park, Hyo Jin Chung, Chang-Hoon Kim, Joo-Heon Yoon, Hyung-Ju Cho
The base of the tongue has been recognized as a significant site of obstruction in patients with obstructive sleep apnea (OSA). Our aim was to determine the independent predictors of surgical success in tongue base resection combined with lateral pharyngoplasty for OSA. Thirty-one OSA patients who underwent endoscopie-guided coblator or transoral robotic tongue base resection in combination with lateral pharyngoplasty for the treatment of retroglossal obstruction between March 2012 and December 2015 were enrolled in this study...
February 21, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28219749/behavioral-phenotypes-associated-with-mptp-induction-of-partial-lesions-in-common-marmosets-callithrix-jacchus
#15
Kimberley A Phillips, Corinna N Ross, Jennifer Spross, Catherine J Cheng, Alyssa Izquierdo, K C Biju, Cang Chen, Senlin Li, Suzette D Tardif
Parkinson's disease is a chronic neurodegenerative disorder with the core motor features of resting tremor, bradykinesia, rigidity, and postural instability. Non-motor symptoms also occur, and include cognitive dysfunction, mood disorders, anosmia (loss of smell), and REM sleep disturbances. As the development of medications and other therapies for treatment of non-motor symptoms is ongoing, it is essential to have animal models that aid in understanding the neural changes underlying non-motor PD symptoms and serve as a testing ground for potential therapeutics...
February 17, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28219726/diagnostic-value-of-sleep-stage-dissociation-as-visualized-on-a-2-dimensional-sleep-state-space-in-human-narcolepsy
#16
Anders Vinther Olsen, Jens Stephansen, Eileen Leary, Paul E Peppard, Hong Sheungshul, Poul Jenum, Helge Sorensen, Emmanuel Mignot
BACKGROUND: Type 1 narcolepsy (NT1) is characterized by symptoms believed to represent Rapid Eye Movement (REM) sleep stage dissociations, occurrences where features of wake and REM sleep are intermingled, resulting in a mixed state. We hypothesized that sleep stage dissociations can be objectively detected through the analysis of nocturnal Polysomnography (PSG) data, and that those affecting REM sleep can be used as a diagnostic feature for narcolepsy. NEW METHOD: A Linear Discriminant Analysis (LDA) model using 38 features extracted from EOG, EMG and EEG was used in control subjects to select features differentiating wake, stage N1, N2, N3 and REM sleep...
February 17, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28217811/-quantitative-evaluation-of-inhibitory-effects-of-epileptic-spikes-on-theta-rhythms-in-the-network-of-hippocampal-ca3-and-entorhinal-cortex-in-patients-with-temporal-lobe-epilepsy
#17
Man-Ling Ge, Jun-Dan Guo, Sheng-Hua Chen, Ji-Chang Zhang, Xiao-Xuan Fu, Yu-Min Chen
Epileptic spike is an indicator of hyper-excitability and hyper-synchrony in the neural networks. The inhibitory effects of spikes on theta rhythms (4-8 Hz) might be helpful to understand the mechanism of epileptic damage on the cognitive functions. To quantitatively evaluate the inhibitory effects of spikes on theta rhythms, intracerebral electroencephalogram (EEG) recordings with both sporadic spikes (SSs) and spike-free transient period between adjacent spikes were selected in 4 patients in the status of rapid eyes movement (REM) sleep with temporal lobe epilepsy (TLE) under the pre-surgical monitoring...
February 25, 2017: Sheng Li Xue Bao: [Acta Physiologica Sinica]
https://www.readbyqxmd.com/read/28215911/conditions-associated-with-rem-sleep-behaviour-disorder-description-of-a-hospital-series
#18
M J Abenza Abildúa, A Miralles Martinez, F J Arpa Gutiérrez, V Lores Gutiérrez, C Algarra Lucas, C Jimeno Montero, B Sánchez García, M Mata Álvarez-Santullano, C Borrue Fernández, G Cordero Martín, G Gutiérrez Cueto, M D Torrecillas Narváez, I Thuissard Vasallo, A Gómez Aceña
INTRODUCTION: REM sleep behaviour disorder (RBD) is characterised by violent behaviours (screaming, kicking, vivid dreams) during REM sleep. It has a prevalence of 1% to 2% of the general population and is especially frequent in men and the population older than 60. In the last decade, RBD has been suggested to be a prodrome of neurodegenerative disease. We analysed associated neurological diseases and responses to drug treatment in 33 patients with RBD treated in the multidisciplinary sleep disorders unit at Hospital Infanta Sofía...
February 16, 2017: Neurología: Publicación Oficial de la Sociedad Española de Neurología
https://www.readbyqxmd.com/read/28215267/a-community-based-study-of-risk-factors-for-probable-rapid-eye-movement-sleep-behavior-disorder
#19
Jian-Fang Ma, Yuan Qiao, Xiang Gao, Liang Liang, Xiao-Li Liu, Dun-Hui Li, Hui-Dong Tang, Sheng-Di Chen
OBJECTIVES: To cross-sectionally explore the potential risk factors for rapid eye movement (REM) sleep behavior disorder (RBD) in a community cohort in Shanghai. METHODS: Based on the validated RBD screening questionnaire (RBDSQ), we identified individuals with probable RBD (pRBD) in 3635 community-dwelling residents (≥50 years old) from an urban community of Shanghai. Potential risk factors of pRBD, including age, sex, smoking, socioeconomic status, obesity, consumption of tea (surrogate for caffeine intake) and alcohol, medications and chronic disease status, were assessed via questionnaire...
February 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28215261/rem-sleep-behavior-disorder-causing-subdural-hematoma
#20
Oscar Ramos-Campoy, Carles Gaig, Monica Villas, Alex Iranzo, Joan Santamaria
No abstract text is available yet for this article.
February 2017: Sleep Medicine
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