keyword
Keywords inflammatory bowel disease AND...

inflammatory bowel disease AND neutrophils

https://read.qxmd.com/read/38347974/tumefactive-crohn-s-disease-mimicking-colon-carcinoma-in-a-young-female-a-case-report
#21
Ali Z Ansari, Sania Razzak, Srihita Patibandla, Sarthak Kumar, Sahar Hafeez, Kurt Kratz
Tumefactive Crohn's disease is a rare form of Crohn's disease that may mimic colon carcinoma macroscopically. This case report describes a 28-year-old female who presented with right-sided abdominal pain and a palpable abdominal mass that had persisted for over a month. Multiple hospitalizations failed to provide an accurate diagnosis until an exploratory laparotomy revealed that the "mass" was the cecum and a perforated ascending colon. A partial right colectomy was performed, sending the specimen for biopsy...
January 2024: Curēus
https://read.qxmd.com/read/38333294/ulcerative-colitis-and-pyoderma-gangrenosum-refractory-to-treatment-successfully-managed-with-pentoxifylline-a-case-report
#22
Miguel A Jiménez-Luévano, Ana E Jiménez-Partida, Miguel A Jiménez-Partida, Georgina Hernández-Flores, César R Cerda-Cruz, Alejandro Bravo-Cuellar, María M Villaseñor-García
INTRODUCTION AND IMPORTANCE: Pyoderma gangrenosum is an unusual inflammatory pathology, with neutrophilic dermatosis, of unknown etiology. It is associated with diseases such as bowel disease. Generally, it is treated with anti-inflammatory drugs, corticosteroids, immunosuppressants, and antibodies against tumor necrosis factor, but relapse and adverse effects are persistent. Pentoxifylline is a drug with immunoregulatory and anti-inflammatory properties. CASE PRESENTATION: A 47-year-old male with a diagnosis of ulcerative colitis initially managed favorably for 7 years with mesalazine...
February 2024: Annals of Medicine and Surgery
https://read.qxmd.com/read/38332364/polymeric-dnase-i-nanozymes-targeting-neutrophil-extracellular-traps-for-the-treatment-of-bowel-inflammation
#23
JOURNAL ARTICLE
Chi-Pin James Wang, Ga Ryang Ko, Yun Young Lee, Juwon Park, Wooram Park, Tae-Eun Park, Yoonhee Jin, Se-Na Kim, Jung Seung Lee, Chun Gwon Park
Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is a family of chronic disorders along the gastrointestinal tract. Because of its idiopathic nature, IBD does not have a fundamental cure; current available therapies for IBD are limited to prolonged doses of immunomodulatory agents. While these treatments may reduce inflammation, limited therapeutic efficacy, inconsistency across patients, and adverse side effects from aggressive medications remain as major drawbacks. Recently, excessive production and accumulation of neutrophil extracellular traps (NETs) also known as NETosis have been identified to exacerbate inflammatory responses and induce further tissue damage in IBD...
February 8, 2024: Nano Convergence
https://read.qxmd.com/read/38330550/macrophage-tim-3-maintains-intestinal-homeostasis-in-dss-induced-colitis-by-suppressing-neutrophil-necroptosis
#24
JOURNAL ARTICLE
Fangfei Wang, Feng Zhou, Jianxiang Peng, Hao Chen, Jinliang Xie, Cong Liu, Huifang Xiong, Sihai Chen, Guohui Xue, Xiaojiang Zhou, Yong Xie
T-cell immunoglobulin domain and mucin domain-3 (Tim-3) is a versatile immunomodulator that protects against intestinal inflammation. Necroptosis is a type of cell death that regulates intestinal homeostasis and inflammation. The mechanism(s) underlying the protective role of macrophage Tim-3 in intestinal inflammation is unclear; thus, we investigated whether specific Tim-3 knockdown in macrophages drives intestinal inflammation via necroptosis. Tim-3 protein and mRNA expression were assessed via double immunofluorescence staining and single-cell RNA sequencing (sc-RNA seq), respectively, in the colonic tissues of patients with inflammatory bowel disease (IBD) and healthy controls...
February 2, 2024: Redox Biology
https://read.qxmd.com/read/38325140/inhibition-of-hmgb1-improves-experimental-mice-colitis-by-mediating-nets-and-macrophage-polarization
#25
JOURNAL ARTICLE
Xiaohong Chen, SaChuLa Bao, Meng Liu, Zheng Han, Jie Tan, Qingxi Zhu, Xiaodong Huang, Xia Tian
OBJECTIVE: Inflammatory bowel disease (IBD) is listed by the World Health Organization as one of the modern intractable diseases. High mobility histone box 1 (HMGB1), originally described as a non-histone nucleoprotein involved in transcriptional regulation, was later identified as a pro-inflammatory cytokine that may contribute to the pathogenesis of inflammatory diseases such as IBD. Neutrophil extracellular traps (NETs) play an important role in the pathophysiology of IBD The aim of this study was to investigate the role of HMGB1 in experimental colitis mice and its potential mechanisms of action...
February 6, 2024: Cytokine
https://read.qxmd.com/read/38304552/multiple-abscess-collections-antibiotics-or-steroids
#26
Philippe Raphael Dias, Levin Bolt, Christof Iking-Konert, Mattia Arrigo, Lars C Huber
Aseptic abscess syndrome (AAS) is a medical rarity. The combination of multiple abscess collections in different organs, negative microbiological studies, and the association with an inflammatory bowel disease is highly suggestive for an AAS. The AAS is an acute neutrophilic dermatosis, so "generalized pyoderma gangraenosum" or "generalized bullous sweet syndrome" might be used synonymously. It is important to note that the diagnosis of an AAS can be made only after careful exclusion of an infectious disease...
2024: Case Reports in Immunology
https://read.qxmd.com/read/38287036/author-correction-macrophage-and-neutrophil-heterogeneity-at-single-cell-spatial-resolution-in-human-inflammatory-bowel-disease
#27
Alba Garrido-Trigo, Ana M Corraliza, Marisol Veny, Isabella Dotti, Elisa Melón-Ardanaz, Aina Rill, Helena L Crowell, Ángel Corbí, Victoria Gudiño, Miriam Esteller, Iris Álvarez-Teubel, Daniel Aguilar, M Carme Masamunt, Emily Killingbeck, Youngmi Kim, Michael Leon, Sudha Visvanathan, Domenica Marchese, Ginevra Caratù, Albert Martin-Cardona, Maria Esteve, Ingrid Ordás, Julian Panés, Elena Ricart, Elisabetta Mereu, Holger Heyn, Azucena Salas
No abstract text is available yet for this article.
January 29, 2024: Nature Communications
https://read.qxmd.com/read/38277989/treatment-recommendations-for-glycogen-storage-disease-type-ib-associated-neutropenia-and-neutrophil-dysfunction-with-empagliflozin-consensus-from-an-international-workshop
#28
REVIEW
Sarah C Grünert, Terry G J Derks, Helen Mundy, R Neil Dalton, Jean Donadieu, Peter Hofbauer, Neil Jones, Sema Kalkan Uçar, Jamas LaFreniere, Enrique Landelino Contreras, Surekha Pendyal, Alessandro Rossi, Blair Schneider, Ronen Spiegel, Karolina M Stepien, Dorota Wesol-Kucharska, Maria Veiga-da-Cunha, Saskia B Wortmann
Glycogen storage disease type Ib (GSD Ib, biallelic variants in SLC37A4) is a rare disorder of glycogen metabolism complicated by neutropenia/neutrophil dysfunction. Since 2019, the SGLT2-inhibitor empagliflozin has provided a mechanism-based treatment option for the symptoms caused by neutropenia/neutrophil dysfunction (e.g. mucosal lesions, inflammatory bowel disease). Because of the rarity of GSD Ib, the published evidence on safety and efficacy of empagliflozin is still limited and does not allow to develop evidence-based guidelines...
January 17, 2024: Molecular Genetics and Metabolism
https://read.qxmd.com/read/38267224/toxigenic-clostridium-perfringens-isolated-from-at-risk-pediatric-inflammatory-bowel-disease-patients
#29
JOURNAL ARTICLE
James Kuo, Jasmina Uzunovic, Amanda Jacobson, Michelle Dourado, Sarah Gierke, Manohary Rajendram, Daniela Keilberg, Jordan Mar, Emily Stekol, Joanna Curry, Sofia Verstraete, Jessica Lund, Yuxin Liang, Fiona B Tamburini, Natalie S Omattage, Matthieu Masureel, Steven T Rutherford, David H Hackos, Man-Wah Tan, Allyson L Byrd, Mary E Keir, Elizabeth Skippington, Kelly M Storek
BACKGROUND AND AIMS: The goal was to identify microbial drivers of IBD, by investigating mucosal-associated bacteria and their detrimental products in IBD patients. METHODS: We directly cultured bacterial communities from mucosal biopsies from pediatric gastrointestinal patients and examined for pathogenicity-associated traits. Upon identifying C. perfringens as toxigenic bacteria present in mucosal biopsies, we isolated strains and further characterized toxicity and prevalence...
January 24, 2024: Journal of Crohn's & Colitis
https://read.qxmd.com/read/38259414/comparing-myelosuppression-frequency-in-indian-inflammatory-bowel-disease-patients-a-randomized-trial-of-full-dose-versus-gradual-escalation-of-thiopurines
#30
JOURNAL ARTICLE
Alok Kumar Singh, Sanjeev Sachdeva, Siddharth Srivastava, Ujjwal Sonika, Ajay Kumar, Barjesh C Sharma, Amarender S Puri, Ashok Dalal
INTRODUCTION: We aimed to compare the frequency of myelosuppression in patients initiating azathioprine (AZA) at full dose versus those undergoing gradual dose escalation. METHODS: Forty patients with inflammatory bowel disease were recruited over one year and randomized into two groups of 20. Group A initiated AZA at a full dose of 2 mg/kg, while group B started at 1 mg/kg with subsequent dose increases at regular intervals. RESULTS: Seventeen patients from each group were included in the final analysis...
December 2023: Curēus
https://read.qxmd.com/read/38256249/serum-amyloid-a-as-a-potential-biomarker-in-inflammatory-bowel-diseases-especially-in-patients-with-low-c-reactive-protein
#31
JOURNAL ARTICLE
Marie Stute, Martin Kreysing, Markus Zorn, Patrick Michl, Annika Gauss
The acute phase protein Serum Amyloid A (SAA) is synthesised by the liver in response to inflammatory stimuli. Previous studies have revealed that SAA may be a better biomarker of disease activity in inflammatory bowel disease (IBD) compared to C-reactive protein (CRP). This retrospective monocentric study evaluated whether SAA correlates with biomarkers like faecal calprotectin (FC), CRP, the Neutrophil to Lymphocyte ratio (NLR), the platelet count and clinical disease activity of IBD patients. Serum samples from the IBD outpatient clinic of the University Hospital Heidelberg were analysed for SAA concentrations if an FC concentration measurement was available from ±14 days to collection of the serum sample...
January 18, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38238446/neutrophil-mediated-type-iv-collagen-degradation-is-elevated-in-patients-with-mild-endoscopic-ulcerative-colitis-reflecting-early-mucosal-destruction
#32
JOURNAL ARTICLE
Marta S Alexdottir, Martin Pehrsson, Viktor Domislovic, Line E Godskesen, Aleksander Krag, Jens Kjeldsen, Marko Brinar, Ana Barisic, Anne-Christine Bay-Jensen, Morten A Karsdal, Zeljko Krznaric, Joachim H Mortensen
Neutrophils play a significant role in sustaining chronic inflammation in Inflammatory Bowel Disease. The intestinal basement membrane acts as a barrier for immunological homeostasis, where the α3 and α4 chains of type IV collagen are expressed on the mucosal surface. We wanted to develop a biomarker reflecting early tissue injury, providing an opportunity for intervention. Two competitive enzyme-linked immunosorbent assays (ELISAs) quantifying human neutrophil elastase (HNE) degraded neo-epitopes of COL4A3 and COL4A4 were developed and investigated in two observational cohorts (n = 161, n = 100)...
January 18, 2024: Scientific Reports
https://read.qxmd.com/read/38231408/-deficiency-in-elf4-x-linked-a-monogenic-disease-entity-resembling-beh%C3%A3-et-s-syndrome-and-inflammatory-bowel-disease
#33
JOURNAL ARTICLE
Sam J Olyha, Shannon K O'Connor, Marat Kribis, Molly L Bucklin, Dinesh Babu Uthaya Kumar, Paul M Tyler, Faiad Alam, Kate M Jones, Hassan Sheikha, Liza Konnikova, Saquib A Lakhani, Ruth R Montgomery, Jason Catanzaro, Hongqiang Du, Daniel V DiGiacomo, Holly Rothermel, Christopher J Moran, Karoline Fiedler, Neil Warner, Esther P A H Hoppenreijs, Caspar I van der Made, Alexander Hoischen, Peter Olbrich, Olaf Neth, Alejandro Rodríguez-Martínez, José Manuel Lucena Soto, Annemarie M C van Rossum, Virgil A S H Dalm, Aleixo M Muise, Carrie L Lucas
Defining monogenic drivers of autoinflammatory syndromes elucidates mechanisms of disease in patients with these inborn errors of immunity and can facilitate targeted therapeutic interventions. Here, we describe a cohort of patients with a Behçet's- and inflammatory bowel disease (IBD)-like disorder termed "deficiency in ELF4, X-linked" (DEX) affecting males with loss-of-function variants in the ELF4 transcription factor gene located on the X chromosome. An international cohort of fourteen DEX patients was assessed to identify unifying clinical manifestations and diagnostic criteria as well as collate findings informing therapeutic responses...
January 17, 2024: Journal of Clinical Immunology
https://read.qxmd.com/read/38229275/reactive-granulomatous-dermatitis-a-descriptive-study-of-10-patients
#34
JOURNAL ARTICLE
Maude Lagacé, Laurence Mainville, Marie-Claude Dionne
BACKGROUND: Reactive granulomatous dermatitis (RGD) is a rare and misunderstood skin disorder. It includes interstitial granulomatous dermatitis and palisaded neutrophilic and granulomatous dermatitis: 2 entities of the same spectrum. Multiple associations are described with RGD in the literature, including autoimmune diseases, malignancy, and drugs. OBJECTIVE: To report and describe the suspected associations with RGD at the time of diagnosis and in the following year...
January 16, 2024: Journal of Cutaneous Medicine and Surgery
https://read.qxmd.com/read/38193202/foxo3-at-the-crossroads-of-metabolic-inflammatory-and-tumorigenic-remodeling-in-the-colon
#35
REVIEW
Patricia Snarski, Jenisha Ghimire, Suzana D Savkovic
The Forkhead box O3 (FOXO3) transcription factor regulates the expression of genes critical for diverse cellular functions in homeostasis. Diminished FOXO3 activity is associated with human diseases such as obesity, metabolic diseases, inflammatory diseases, and cancer. In the mouse colon, FOXO3 deficiency leads to an inflammatory immune landscape and dysregulated molecular pathways, which, under various insults, exacerbates inflammation and tumor burden, mimicking characteristics of human diseases. This deficiency also results in dysregulated lipid metabolism, and consequently, the accumulation of intracellular lipid droplets (LDs) in colonic epithelial cells and infiltrated immune cells...
January 9, 2024: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://read.qxmd.com/read/38189700/emerging-role-of-the-il-36-il-36r-axis-in-multiple-inflammatory-skin-diseases
#36
REVIEW
Fareed Ahmad, Majid Ali Alam, Abdul Wahid Ansari, Anh Jochebeth, Rari Leo, Mohammed Nasser Al-Abdulla, Sara Al-Khawaga, Ayda AlHammadi, Aysha Al-Malki, Khalifa Al Naama, Aamir Ahmad, Jörg Buddenkotte, Martin Steinhoff
IL-36 is a most recent member of the IL-1 cytokine family, primarily expressed at barrier sites of the body such as the skin, lungs, and intestine. It plays a vital role in inflammation and is implicated in the development of various cutaneous; intestinal; and pulmonary disorders, including psoriasis, inflammatory bowel disease, and chronic obstructive pulmonary disease. IL-36 comprises 4 isoforms: the proinflammatory IL-36α, IL-36β, and IL-36γ and the anti-inflammatory IL-36R antagonist. An imbalance between proinflammatory and anti-inflammatory IL-36 isoforms can contribute to the inflammatory fate of cells and tissues...
February 2024: Journal of Investigative Dermatology
https://read.qxmd.com/read/38187026/narrative-review-pyoderma-gangrenosum
#37
REVIEW
Ann N Park, Aishwarya Raj, Joe Bajda, Vasavi R Gorantla
Pyoderma gangrenosum (PG) is a skin lesion, characteristically a neutrophilic dermatosis, that can be complicated by rapid progression, necrosis, and ulceration. This is an important pathology to be discussed given that there are no established criteria for diagnosis or treatment. This review aims to elucidate characteristics and variations of PG that distinguish it from other ulcerative skin lesions. Variability in presentation can lead to missed or incorrect diagnosis, and some of the currently proposed criteria for categorizing and diagnosing PG have been included here...
January 2024: Curēus
https://read.qxmd.com/read/38184420/autoimmune-pancreatitis-biopsy-interpretation-and-differential-diagnosis
#38
REVIEW
Yoh Zen
Autoimmune pancreatitis (AIP) is classified into type 1 (IgG4-related) and type 2 (IgG4-unrelated) and the interpretation of pancreatic biopsy findings plays a crucial role in their diagnosis. Needle biopsy of type 1 AIP in the acute or subacute phase shows a diffuse lymphoplasmacytic infiltrate, storiform fibrosis, obliterative phlebitis, and the infiltration of many IgG4-positive plasma cells. In a later phase, changes become less inflammatory and more fibrotic, making interpretations more challenging. Confirmation of the lack of 'negative' findings that are unlikely to occur in type 1 AIP (e...
January 3, 2024: Seminars in Diagnostic Pathology
https://read.qxmd.com/read/38164522/the-treatment-regimens-and-disease-activity-could-alter-the-salivary-myeloperoxidase-levels-in-patients-with-inflammatory-bowel-diseases
#39
JOURNAL ARTICLE
Kacper Nijakowski, Barbara Motylewska, Estera Banasik, Rafał Rutkowski, Vasili Tsaryk, Joanna Łuczak, Katarzyna Korybalska, Janusz Witowski, Anna Surdacka, Piotr Eder
INTRODUCTION: Inflammatory bowel diseases (IBDs) are related to alternating periods of exacerbation and remission; therefore, it is necessary to develop non-invasive diagnostic tools to control disease activity and improve therapeutic effectiveness. Recently, we found that patients with ulcerative colitis (UC) who qualified for biologic therapy had significantly lower salivary myeloperoxidase (MPO) levels. OBJECTIVES: This cross-sectional study aimed to assess the impact of IBD activity and applied treatment on salivary antioxidant status as reflected by MPO, catalase and total antioxidant status levels...
January 2, 2024: Polish Archives of Internal Medicine
https://read.qxmd.com/read/38160439/clinicopathologic-characterization-of-lymphocytic-colitis-in-the-pediatric-population
#40
JOURNAL ARTICLE
Iván A González, Maire Conrad, Sarah Weinbrom, Trusha Patel, Judith R Kelsen, Pierre Russo
BACKGROUND: Lymphocytic colitis (LC) in the pediatric population has been associated with immune dysregulation. METHODS: Single-center retrospective study of pediatric LC. RESULTS: 50 patients (35 female, 70%) with a median age of 12 years at diagnosis (interquartile range: 5.7-15.8) of LC were identified. At presentation, 11 patients (22%) had malnutrition, 16 (32%) had a known underlying immune dysregulation, 4 (8%) had celiac disease (CD), and none had a diagnosis of inflammatory bowel disease...
December 31, 2023: Pediatric and Developmental Pathology
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