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https://www.readbyqxmd.com/read/29040430/transcriptomic-landscape-of-treatment-na%C3%A3-ve-ulcerative-colitis
#1
Hagar Taman, Christopher G Fenton, Inga V Hensel, Endre Anderssen, Jon Florholmen, Ruth H Paulssen
Background and Aims: Ulcerative colitis (UC) is a chronic inflammatory disease that effects the gastrointestinal tract and is considered one of the most prominent and common forms of inflammatory bowel disease (IBD). This study aimed to define and describe the entire transcriptomic landscape in a well-stratified, treatment-naïve UC patient population compared to control patients by using next-generation technology, RNA-Seq. Methods: Mucosal biopsies from treatment-naïve UC patients (n=14), and healthy controls (n=16) underwent RNA-Seq...
October 10, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29019857/interleukin-27-is-a-potential-rescue-therapy-for-acute-severe-colitis-through-interleukin-10-dependent-t-cell-independent-attenuation-of-colonic-mucosal-innate-immune-responses
#2
Mairi H McLean, Caroline Andrews, Miranda L Hanson, Walter A Baseler, Miriam R Anver, Emilee Senkevitch, Aleksandra K Staniszewska, Christopher Smith, Luke C Davies, Julie Hixon, Wenqeng Li, Wei Shen, Lothar Steidler, Scott K Durum
BACKGROUND: If treatment with intravenous steroids fail, inflammatory bowel disease patients with acute severe colitis face systemic anti-tumor necrosis factor biologic rescue therapy or colectomy. Interleukin (IL)-27 is a cytokine with an immunosuppressive role in adaptive immune responses. However, the IL-27 receptor complex is also expressed on innate immune cells, and there is evidence that IL-27 can impact the function of innate cell subsets, although this particular functionality in vivo is not understood...
November 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28993983/skin-manifestations-associated-with-autoimmune-liver-diseases-a-systematic-review
#3
REVIEW
Benedetta Terziroli Beretta-Piccoli, Pietro Invernizzi, M Eric Gershwin, Carlo Mainetti
Autoimmune liver diseases, which include mainly autoimmune hepatitis, primary biliary cholangitis, primary sclerosing cholangitis, and the variant syndromes, are often associated with extrahepatic autoimmune diseases. However, the association with cutaneous diseases is less well described. In the present article, we provide a systematic literature review on skin manifestations linked to each of these four autoimmune liver diseases, excluding skin manifestations of systemic diseases. The association of autoimmune hepatitis with vitiligo is well known, with a particular striking association with type 2 autoimmune hepatitis, a condition occurring almost entirely in children and adolescents, much rarer and more aggressive than type 1 autoimmune hepatitis; probable associations are also identified with alopecia areata, psoriasis, and pyoderma gangrenosum...
October 9, 2017: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/28955241/lack-of-histamine-h4-receptor-expression-aggravates-tnbs-induced-acute-colitis-symptoms-in-mice
#4
Eva J Wunschel, Bastian Schirmer, Roland Seifert, Detlef Neumann
Inflammatory bowel diseases (IBD) are a growing health problem worldwide, severely affecting patients' life qualities and life expectancies. Therapeutic options, which are rare and focus on symptoms associated with the disease, suffer from increasing numbers of patients refractory to the established strategies. Thus, in order to generate new therapeutic regimens, the detailed understanding of the pathogenic mechanisms causing IBD is necessary. Histamine is an inflammatory mediator associated with IBD. Four histamine receptors are currently known of which the histamine H4-receptor (H4R) has been shown to possess a pro-inflammatory function in several experimental models of inflammatory diseases, including dextran sodium sulfate (DSS)-induced colitis in mice...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28935867/s100a4-contributes-to-colitis-development-by-increasing-the-adherence-of-citrobacter-rodentium-in-intestinal-epithelial-cells
#5
Jinhua Zhang, Ying Jiao, Shasha Hou, Tian Tian, Qi Yuan, Huaijie Hao, Zhenlong Wu, Xuexiang Bao
S100A4 has been implicated in cancer and several inflammatory diseases, but its role in inflammatory bowel disease has not been well investigated. Here, upon infection with Citrobacter rodentium, a model for enteropathogenic Escherichia coli infection in humans, induced the infiltration of a large number of S100A4(+) cells into the colon in wild type (WT) mice. Deficiency of S100A4 reduced weight loss, bacterial colonization and colonic pathology. Furthermore, the expression of inflammatory cytokines and the recruitment of macrophages and neutrophils also decreased significantly in S100A4 knock out (S100A4 (-/-)) mice...
September 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28917218/erythema-elevatum-diutinum-in-crohn-s-disease-associated-spondyloarthritis-a-rare-vasculitis-an-unusual-association
#6
Maria João Gonçalves, Vasco C Romão, Luís Soares-de-Almeida, Helena Canhão, José Carlos Romeu, Heinz Kutzner, José Alberto Pereira-da-Silva
Erythema elevatum diutinum is a rare neutrophilic dermatoses with vasculitis, which presents as persistent, symmetrical, purple or brownish papules and nodules, mainly in the extensor surface of the limbs. We describe a case of erythema elevatum diutinum and polyarthritis as initial manifestations of Crohn's disease associated spondyloarthritis. A 51-year-old man, from São Tomé e Príncipe, with previous history of treated tuberculosis and chronic hepatitis B infection, was admitted due to 4 months history of polyarthritis, hyperpigmented papules on the extensor surfaces, occasional episodes of bloody mucous diarrhea and significant weight loss...
September 14, 2017: Acta Reumatológica Portuguesa
https://www.readbyqxmd.com/read/28915774/pyoderma-gangrenosum-a-current-problem-as-much-as-an-unknown-one
#7
Valerio Vallini, Roberto Andreini, Angelo Bonadio
Pyoderma gangrenosum (PG) is a rare neutrophilic inflammatory skin disease, characterized by recurrent skin ulcers, which in almost 50% of cases are associated with systemic autoimmune disorders, including rheumatoid arthritis, chronic hepatitis, inflammatory bowel disease, paraproteinemias and hematological malignancies. A systematic search of literature for PG was carried out using the PubMed, Embase, and Google Scholar databases for the purpose of this review and 2780 articles were retrieved up to February 2017...
September 2017: International Journal of Lower Extremity Wounds
https://www.readbyqxmd.com/read/28869330/butyrate-loaded-chitosan-hyaluronan-nanoparticles-a-suitable-tool-for-sustained-inhibition-of-ros-release-by-activated-neutrophils
#8
Pasquale Sacco, Eva Decleva, Fabio Tentor, Renzo Menegazzi, Massimiliano Borgogna, Sergio Paoletti, Kåre Andre Kristiansen, Kjell Morten Vårum, Eleonora Marsich
Tissue damage caused by excessive amounts of neutrophil-derived reactive oxygen species (ROS) occurs in many inflammatory diseases. Butyrate is a short-chain fatty acid (SCFA) with known anti-inflammatory properties, able to modulate several neutrophil functions. Evidence is provided here that butyrate inhibits neutrophil ROS release in a dose and time-dependent fashion. Given the short half-life of butyrate, chitosan/hyaluronan nanoparticles are next designed and developed as controlled release carriers able to provide cells with a long-lasting supply of this SCFA...
September 4, 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/28857501/potential-roles-of-neutrophils-in-regulating-intestinal-mucosal-inflammation-of-inflammatory-bowel-disease
#9
REVIEW
Guang Xi Zhou, Zhan Ju Liu
Inflammatory bowel diseases (IBD), comprising of ulcerative colitis and Crohn's disease, are inflammatory disorders of the gastrointestinal tract characterized by chronically relapsing mucosal inflammation. Neutrophils, as the effector cells of acute inflammation, have long been reported to play a role in the maintenance of intestinal homeostasis and pathogenesis of IBD. At the early stage of mucosal inflammation in patients with IBD, neutrophils flood into intestinal mucosa, phagocytose pathogenic microbes, and promote mucosal healing and resolution of inflammation...
September 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28855088/drug-nanocarriers-to-treat-autoimmunity-and-chronic-inflammatory-diseases
#10
REVIEW
Davide Prosperi, Miriam Colombo, Ivan Zanoni, Francesca Granucci
Nanoparticles represent a new generation of drug delivery systems that can be engineered to harness optimal target selectivity for specific cells and tissues and high drug loading capacity, allowing for improved pharmacokinetics and enhanced bioavailability of therapeutics. The spontaneous propensity of both organic and colloidal nanoparticles to be captured by the cells of the reticuloendothelial system encouraged their utilization as passive targeting systems that can be preferentially directed to innate immune cells, such as macrophages, dendritic cells and neutrophils...
August 28, 2017: Seminars in Immunology
https://www.readbyqxmd.com/read/28821031/surface-deacetylated-chitin-nanofibers-reinforced-with-a-sulfobutyl-ether-%C3%AE-cyclodextrin-gel-loaded-with-prednisolone-as-potential-therapy-for-inflammatory-bowel-disease
#11
Ryo Tabuchi, Makoto Anraku, Daisuke Iohara, Takako Ishiguro, Shinsuke Ifuku, Tomone Nagae, Kaneto Uekama, Shoko Okazaki, Keizo Takeshita, Masaki Otagiri, Fumitoshi Hirayama
Surface-deacetylated chitin nanofibers (SDACNFs) reinforced with a sulfobutyl ether β-cyclodextrin (SBE-β-CD) (NFs-CDs) gel were developed to obtain a controlled release carrier of prednisolone (PD) for the treatment of colitis. PD was released slowly from the gel at both pH 1.2 and 6.8. The in vitro slow release of PD from the NFs-CDs gel was reflected in the in vivo absorption of the drug after oral administration to rats. These results suggest that a simple gel composed of a mixture of SDACNFs and SBE-β-CD has the potential for use in the controlled release of PD...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28817583/dextran-sodium-sulfate-dss-induces-necrotizing-enterocolitis-like-lesions-in-neonatal-mice
#12
Marco Ginzel, Xiaoyan Feng, Joachim F Kuebler, Christian Klemann, Yi Yu, Reinhard von Wasielewski, Joon-Keun Park, Mathias W Hornef, Gertrud Vieten, Benno M Ure, Torsten Kaussen, Jan Hendrik Gosemann, Steffi Mayer, Anne Suttkus, Martin Lacher
BACKGROUND: Necrotizing enterocolitis (NEC) is an inflammatory bowel disease of preterm human newborns with yet unresolved etiology. An established neonatal murine model for NEC employs oral administration of lipopolysaccharides (LPS) combined with hypoxia/hypothermia. In adult mice, feeding dextran sodium sulfate (DSS) represents a well-established model for experimental inflammatory bowel disease. Here we investigated the effect of DSS administration on the neonatal murine intestine in comparison with the established NEC model...
2017: PloS One
https://www.readbyqxmd.com/read/28799796/immune-modulation-by-curcumin-the-role-of-interleukin-10
#13
Hamid Mollazadeh, Arrigo F G Cicero, Christopher N Blesso, Matteo Pirro, Muhammed Majeed, Amirhossein Sahebkar
Cytokines are small secreted proteins released by different types of cells with specific effects on cellular signaling and communication via binding to their receptors on the cell surface. IL-10 is known to be a pleiotropic and potent anti-inflammatory and immunosuppressive cytokine that is produced by both innate and adaptive immunity cells including dendritic cells, macrophages, mast cells, natural killer cells, eosinophils, neutrophils, B cells, CD8(+) T cells, and TH1, TH2, and TH17 and regulatory T cells...
August 11, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/28794235/integrin-linked-kinase-expression-in-myeloid-cells-promotes-inflammatory-signaling-during-experimental-colitis
#14
Afsar U Ahmed, Howard C H Yim, Mariah Alorro, Matthias Ernst, Bryan R G Williams
The pathology of inflammatory bowel diseases is driven by the inflammatory signaling pathways associated with mucosal epithelial damage. Myeloid cells are known to play an essential role in mediating epithelial inflammatory responses during injury. However, the precise role of these cells in stimulating intestinal inflammation and the subsequent tissue damage is unclear. In this article, we show that expression of integrin-linked kinase (ILK) in myeloid cells is critical for the epithelial inflammatory signaling during colitis induced by dextran sodium sulfate...
August 9, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28752373/skin-manifestations-of-rheumatoid-arthritis-juvenile-idiopathic-arthritis-and-spondyloarthritides
#15
REVIEW
Carolyn Jean Chua-Aguilera, Burkhard Möller, Nikhil Yawalkar
Extra-articular manifestations of rheumatoid arthritis, juvenile idiopathic arthritis, and various spondyloarthritides including psoriatic arthritis, ankylosing spondylitis, reactive arthritis, and inflammatory bowel disease-associated spondyloarthritis often involve the skin and may occur before or after diagnosis of these rheumatic diseases. Cutaneous manifestations encompass a wide range of reactions that may have a notable negative impact not only on the physical but especially on the emotional and psychosocial well-being of these patients...
July 27, 2017: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/28722377/-sweet-s-syndrome-a-diagnosis-to-keep-in-mind
#16
Caroline Lang, Sandrine Quenan
Sweet's syndrome is a rare neutrophilic dermatosis. Typically, patients present with a sudden onset of tender erythematous skin lesions (papules, nodules, and plaques), of asymetrical distribution, located preferentially on the superior limbs, face and neck, associated whith high fever and neutrophilia. Histologicaly, there is a diffuse infiltrate of neutrophils located in the dermis. Most of the time idiopathic, it may be associated with a respiratory or gastro-intestinal infection, with inflammatory bowel disease, pregnancy and vaccination...
March 29, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28708568/reference-values-of-fecal-calgranulin-c-s100a12-in-school-aged-children-and-adolescents
#17
Anke Heida, Anneke C Muller Kobold, Lucie Wagenmakers, Koos van de Belt, Patrick F van Rheenen
BACKGROUND: Calgranulin C (S100A12) is an emerging marker of inflammation. It is exclusively released by activated neutrophils which makes this marker potentially more specific for inflammatory bowel disease (IBD) compared to established stool markers including calprotectin and lactoferrin. We aimed to establish a reference value for S100A12 in healthy children and investigated whether S100A12 levels can discriminate children with IBD from healthy controls. METHODS: In a prospective community-based reference interval study we collected 122 stool samples from healthy children aged 5-19 years...
July 14, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28708427/monitoring-and-detection-of-disease-recurrence-after-resection-for-crohn-s-disease-the-role-of-non-invasive-fecal-biomarkers
#18
Takayuki Yamamoto, Takahiro Shimoyama
Ileocolonoscopy is the gold standard for the diagnosis and assessment of postoperative recurrence in Crohn's disease (CD). Nevertheless, endoscopy is time-consuming and invasive. A minimally invasive and simple screening test would improve patient adherence to examination and provide greater clinical benefit. A number of fecal biomarkers have been evaluated for their utility for the diagnosis and monitoring of inflammatory bowel disease as alternative tests to endoscopy. Area covered: In this review, we focused on the utility of fecal biomarkers in the management of postoperative CD...
July 18, 2017: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28706419/intestinal-anti-inflammatory-activity-of-ground-cherry-physalis-angulata-l-standardized-co2-phytopharmaceutical-preparation
#19
Luiz Domingues Almeida Junior, Ana Elisa Valencise Quaglio, Celso Acácio Rodrigues de Almeida Costa, Luiz Claudio Di Stasi
AIM: To investigate the effects of Ground Cherry (Physalis angulata L.) standardized supercritical CO2 extract in trinitrobenzenesulphonic acid (TNBS) model of rat intestinal inflammation. METHODS: The animals were divided into groups that received vehicle or P. angulata extract (PACO2) orally at the doses 25, 50 and 100 mg/kg daily by 5 d before TNBS damage. Protective effects of PACO2 were assessed by macroscopic analysis, biochemical determinations of the levels of myeloperoxidase (MPO), alkaline phosphatase (ALP), glutathione and cytokines (such as INF-γ, IL-1β, IL-6, IL-10 and TNF-α), gene expression evaluation (including Hsp70, heparanase, NF-κB, mitogen-activated protein kinases (Mapk) 1, 3, 6 and 9, and the mucins genes Muc 1, 2, 3 and 4) and histopathological studies using optical, and electronic (transmission and scanning) microscopy...
June 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28705292/a-case-of-ischemia-induced-perianal-ulceration-mimicking-pyoderma-gangrenosum
#20
Michael Joseph Lavery, Nicola Cooke
A 68-year-old woman, with a 75-pack-year smoking history and a history of chronic excess alcohol intake, presented with a 5-week history of worsening perianal pain and ulceration. She recently had an inpatient admission with back pain and urinary tract infection during which she developed diarrhea and fecal incontinence. Initially, the perianal ulceration was diagnosed as severe irritant contact dermatitis and treated with barrier creams and topical clobetasone 17-butyrate 0.05% weight for weight, oxytetracycline 3...
2017: Skinmed
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