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https://www.readbyqxmd.com/read/27865960/identification-of-inonotus-obliquus-polysaccharide-with-broad-spectrum-antiviral-activity-against-multi-feline-viruses
#1
Jin Tian, Xiaoliang Hu, Dafei Liu, Hongxia Wu, Liandong Qu
Inonotus obliquus polysaccharides (IOPs) are a potential drug for the prevention and treatment of cancer, cardiopathy, diabetes, AIDs, pancreatitis and other diseases. In this study, we found that IOP can act as a broad-spectrum antiviral drug against feline viruses in the in vitro experiment. Using cell models of feline calicivirus (FCV), we demonstrated that IOP treatment was capable of exhibiting anti-FCV strain F9 activity in cell-based assays and also showed low cytotoxicity. Investigation of the mechanism of action of the compound revealed that IOP treatment induces its inhibitory actions directly on virus particles through blocking viral binding/absorpting...
November 16, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27530514/cardioprotective-role-of-peroxisome-proliferator-activated-receptor-%C3%AE-agonist-rosiglitazone-in-a-unique-murine-model-of-diabetic-cardiopathy
#2
Suresh R Giri, Bibhuti Bhoi, Mukul R Jain, Madhumanjiri M Gatne
AIMS: Rosiglitazone (RSZ), a PPARγ agonist was potent efficacious insulin sensitizing blockbuster drug for treatment of Type 2 diabetes mellitus (T2DM) but the benefit of PPARγ activation in congestive heart failure (CHF) was controversial. The present work was planned to study the role of RSZ in diabetic cardiopathy. MAIN METHODS: Zucker fa/fa rats, the genetic model of T2DM were subjected to constriction of suprarenal abdominal aorta so that they represent a combined model of diabetes and cardiopathy...
October 1, 2016: Life Sciences
https://www.readbyqxmd.com/read/27354356/eets-and-ho-1-cross-talk
#3
REVIEW
David Sacerdoti, Paola Pesce, Marco Di Pascoli, Massimo Bolognesi
Epoxygenase-dependent metabolites of arachidonc acid, EETs and the heme-oxygenase (HO)-1/carbon monoxide/bilverdin system share similarities in their activity and mediators. They control endothelial function, dilating small arterial vessels, decrease blood pressure, protect the heart from ischemic and hypertensive cardiopathy, control renal circulation and function, promote angiogenesis and organ regeneration, oppose oxidative stress and inflammation, improve diabetes and obesity, have protective effects on the liver, and participate in portal hypertension...
September 2016: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/27316658/recipient-age-impact-on-outcome-after-cardiac-transplantation-should-it-still-be-considered-in-organ-allocation
#4
Sandro Sponga, Laura Deroma, Roberta Sappa, Daniela Piani, Andrea Lechiancole, Enrico Spagna, Vincenzo Tursi, Chiara Nalli, Ugolino Livi
OBJECTIVES: Improvement of clinical results in heart transplantation (HTx) has favoured the expansion of indication criteria towards aged population. The impact of increasing recipient age is controversial and, owing to donor shortage, the debate still remains whether HTx is justified for older patients. We analysed age as a prognostic factor at long-term after HTx and if it should be a determinant in organ allocation. METHODS: Data of 364 consecutive patients who underwent cardiac transplantation between 1999 and 2014 at the University Hospital of Udine were analysed...
October 2016: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/27254312/electrocardiographic-left-atrial-abnormalities-and-risk-of-incident-stroke-in-hypertensive-patients-with-electrocardiographic-left-ventricular-hypertrophy
#5
Peter M Okin, Hooman Kamel, Sverre E Kjeldsen, Richard B Devereux
BACKGROUND: Recent findings in population-based studies suggest that abnormal P wave terminal force in lead V1 (PTFV1), a marker of left atrial abnormalities such as fibrosis, dilatation and elevated filling pressures, is associated with incident ischemic stroke, even in the absence of atrial fibrillation. However, whether PTFV1 predicts incident stroke in hypertensive patients during blood pressure lowering has not been examined. METHODS: Risk of incident stroke was examined in relation to abnormal PTFV1 on a baseline ECG in 7778 hypertensive patients with ECG left ventricular hypertrophy, no history of atrial fibrillation, in sinus rhythm on their baseline ECG with no incident atrial fibrillation during follow-up, who were randomly assigned to losartan-based or atenolol-based treatment...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27044324/trim37-deficient-mice-recapitulate-several-features-of-the-multi-organ-disorder-mulibrey-nanism
#6
Kaisa M Kettunen, Riitta Karikoski, Riikka H Hämäläinen, Teija T Toivonen, Vasily D Antonenkov, Natalia Kulesskaya, Vootele Voikar, Maarit Hölttä-Vuori, Elina Ikonen, Kirsi Sainio, Anu Jalanko, Susann Karlberg, Niklas Karlberg, Marita Lipsanen-Nyman, Jorma Toppari, Matti Jauhiainen, J Kalervo Hiltunen, Hannu Jalanko, Anna-Elina Lehesjoki
Mulibrey nanism (MUL) is a rare autosomal recessive multi-organ disorder characterized by severe prenatal-onset growth failure, infertility, cardiopathy, risk for tumors, fatty liver, and type 2 diabetes. MUL is caused by loss-of-function mutations in TRIM37, which encodes an E3 ubiquitin ligase belonging to the tripartite motif (TRIM) protein family and having both peroxisomal and nuclear localization. We describe a congenic Trim37 knock-out mouse (Trim37(-/-)) model for MUL. Trim37(-/-) mice were viable and had normal weight development until approximately 12 months of age, after which they started to manifest increasing problems in wellbeing and weight loss...
2016: Biology Open
https://www.readbyqxmd.com/read/26913747/-clopidogrel-induced-hepatotoxicity-in-hemodialyzed-patient-a-case-report
#7
Sergio Papagni, Carmen Bonifati, Filippo Dagostino, Angelo Marco Murgo
Drug-induced liver injury is a frequent cause of acute liver failure. It may cause clinical manifestations ranging from simple alteration of the common liver function tests until more severe manifestations including encephalopathy, coagulopathy, and in many cases progressive multi-organ dysfunction. The condition, therefore, may be associated with higher morbidity and mortality as well as higher consumption of economic resources. In this paper, we present the case of a 71-year-old patient treated with hemodialysis, diabetic, with ischemic cardiopathy and severe peripheral vascular disease...
January 2016: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://www.readbyqxmd.com/read/26877521/p-208-stroke-in-the-elderly-admitted-to-the-reception-room-of-life-threatening-emergencies-study-of-prognostic-factors
#8
A Sayhi, N Mtaoua, N B Mefteh, N Ridene, A Kheli
OBJECTIFS: L'accident vasculaire cérébral (AVC) est une pathologie grave, invalidante et de plus en plus fréquente avec le vieillissement de la population. C'est l'urgence neurologique la plus fréquente mettant en jeu le pronostic vital et susceptible d'entraîner une morbi-mortalité non négligeable si la prise en charge médicale n'est pas optimale dès les premières heures. Le but de notre travail est d'analyser les aspects épidémiologiques, cliniques, tomodensitométriques et de dégager les facteurs pronostiques des AVC du sujet âgé admis à la SAUV...
December 2015: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/26877486/p-178-diuretics-prescription-and-assessment-of-practices-in-pediatric-intensive-care-unit-university-hospital-of-oran
#9
D Batouche, K Elhalimi, N Benatta, N Chaib, S Abas-Sini, Y Touhami, M A Negadi, Z Mentouri
OBJECTIFS: Les indications de prescription des diurétiques sont diverses notamment en milieu de réanimation. Elles peuvent être bien conduites sous réserve d'un monitorage de la volémie. Ce travail, a pour objectif d'évaluer l'utilisation des diurétiques en réanimation au niveau des indications de prescriptions. MéTHODES: Étude monocentrique rétrospective incluant tous les patients hospitalisés en réanimation pédiatrique sur une période de janvier 1997 à décembre 2014, chez qui une prescription des diurétiquesétait indiquée...
December 2015: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/26877401/p-098-clinical-evaluation-and-risk-factors-of-stroke-hospitalized-at-the-internal-medicine-department-of-the-university-hospital-of-sidi-bel-abbes-algeria
#10
M Chami, M Taleb, W Zahdour, S Maamar, Z Nadji, N Belhadj, F Arbia-Boudjelthia, S Benteldja, A Babou
OBJECTIFS: L'Accident Vasculaire Cérébral est un problème de santé publique en Algérie, de par sa fréquence et sa morbi-mortalité, c'est la troisième cause de décès et la première cause de handicap. Selon les dernières estimations 40 000 cas d'AVC surviennent chaque année en Algérie. Sa prise en charge souffre de beaucoup d'insuffisances en raison de la rareté des unités neurovasculaires. Le but de notre étude est de préciser le type d'AVC, les facteurs de risque, le délai d'admission et le score NIHSS des AVC hospitalisés en médecine interne...
December 2015: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/26877356/p-054-evaluation-of-longitudinal-systolic-function-in-hypertensive-diabetic-about-30-cases
#11
N Taleb Bendiab, A Meziane-Tani
OBJECTIFS: L'HTA est responsable de nombreux remaniements structurels myocardiques avec une fibrose, conduisant à l'hypertrophie ventriculaire gauche et à l'altération progressive dans le temps des fonctions systolo-diastoliques du ventricule gauche. L'HTA et le diabète de type 2 sont des causes importantes de dysfonctionnement ventriculaire et des facteurs de risque d'insuffisance cardiaque. Les données actuelles suggèrent que la dysfonction systolique longitudinale du VG est retrouvée dans les premiers stades de la cardiomyopathie hypertensive...
December 2015: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/26877339/p-044-high-prevalence-of-hypertension-and-diabetes-in-afro-caribbeans-with-heart-failure
#12
J Favier, L Corvo, C T Michel, J Yssap, O Elaoufi, L Foucan, L Larifla
OBJECTIFS: L'insuffisance cardiaque pose, par sa fréquence et sa gravité, un problème majeur de santé publique. Plusieurs facteurs peuvent influencer le risque de survenue d'une insuffisance cardiaque et expliquer les variations de prévalence et d'étiologie de cette pathologie entre différentes populations ou groupes ethniques. En Guadeloupe, où environ 85 % de la population est de type Afro-Caribéen, on observe une forte prévalence de certains facteurs de risque cardiovasculaires (FDRCV), tels que l'hypertension artérielle (30 %), le diabète (8 %) ou l'obésité (23 %), mais les données épidémiologiques concernant l'insuffisance cardiaque sont peu nombreuses...
December 2015: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/26537523/drug-induced-qtc-interval-prolongation-a-multicenter-study-to-detect-drugs-and-clinical-factors-involved-in-every-day-practice
#13
Guillermo A Keller, Paulino A Alvarez, Marcelo L Ponte, Waldo H Belloso, Claudia Bagnes, Cecilia Sparanochia, Claudio D Gonzalez, M Cecilia Villa Etchegoyen, Roberto A Diez, Guillermo Di Girolamo
OBJECTIVE: The actual prevalence of drug induced QTc prolongation in clinical practice is unknown. Our objective was to determine the occurrence and characteristics of drug-induced QT prolongation in several common clinical practices. Additionally, a subgroup of patients treated with dextropropoxyphene of particular interest for the regulatory authority was analysed. RESEARCH DESIGN AND METHODS: Medical history and comorbidities predisposing to QT interval prolongation were registered for 1270 patient requiring medical assistance that involved drug administration...
2016: Current Drug Safety
https://www.readbyqxmd.com/read/26416577/fatty-acid-transport-proteins-in-disease-new-insights-from-invertebrate-models
#14
REVIEW
Pierre Dourlen, Alyson Sujkowski, Robert Wessells, Bertrand Mollereau
The dysregulation of lipid metabolism has been implicated in various diseases, including diabetes, cardiopathies, dermopathies, retinal and neurodegenerative diseases. Mouse models have provided insights into lipid metabolism. However, progress in the understanding of these pathologies is hampered by the multiplicity of essential cellular processes and genes that modulate lipid metabolism. Drosophila and Caenorhabditis elegans have emerged as simple genetic models to improve our understanding of these metabolic diseases...
October 2015: Progress in Lipid Research
https://www.readbyqxmd.com/read/26309656/effect-of-percutaneous-renal-sympathetic-nerve-radiofrequency-ablation-in-patients-with-severe-heart-failure
#15
Qiming Dai, Jing Lu, Benwen Wang, Genshan Ma
This study aimed to investigate the clinical feasibility and effects of percutaneous renal sympathetic nerve radiofrequency ablation in patients with heart failure. A total of 20 patients with heart failure were enrolled, aged from 47 to 75 years (63±10 years). They were divided into the standard therapy (n = 10), and renal nerve radiofrequency ablation groups (n = 10). There were 15 males and 5 female patients, including 8 ischemic cardiomyopathy, 8 dilated cardiomyopathy, and 8 hypertensive cardiopathy. All of the patients met the criteria of New York Heart Association classes III-IV cardiac function...
2015: International Journal of Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/26025035/predictors-of-marked-weight-gain-in-a-population-of-health-care-and-industrial-workers-following-smoking-cessation
#16
MULTICENTER STUDY
Andreas Scherr, Bruno Seifert, Martin Kuster, Anja Meyer, Karl-Olov Fagerstroem, Michael Tamm, Daiana Stolz
BACKGROUND: Concerns about postcessational weight gain might hamper rather than encourage smokers to quit smoking. METHODS: We conducted a comprehensive multi-institutional smoking cessation program for health care and industrial workers (n = 654) employed at University Hospital Basel (Switzerland) and two local health industry companies (Novartis International AG, F. Hoffmann-La Roche AG). The program contained counselling with an option of pharmacological support...
2015: BMC Public Health
https://www.readbyqxmd.com/read/25928514/perineostomy-the-last-oportunity
#17
Juan Carlos Regueiro Lopez, Enrique Gomez Gomez, Alberto Alonso Carrillo, Roque Cano Castineira, Maria Jose Requena Tapia
OBJECTIVE: To review the technique and outcome of perineal urethrostomy or urethral perineostomy and to identify factors related to the procedure failure. MATERIAL AND METHODS: We studied 17 patients who underwent perineal urethrostomy between 2009-2013 in a single hospital. Success was defined as no need for additional surgical treatment or urethral dilatation. We reviewed the clinical data related to age, weight, previous urethral surgery, diabetes, hypertension, ischemic cardiopathy, lichen sclerosus and other causes and studied their association with the procedure failure (univariate analysis)...
January 2015: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/25585824/peritoneal-ultrafiltration-in-congestive-heart-failure-findings-reported-from-its-application-in-clinical-practice-a-systematic-review
#18
REVIEW
Giusto Viglino, Loris Neri, Mauro Feola
INTRODUCTION: Peritoneal ultrafiltration (PUF) is proposed in the long-term treatment of congestive heart insufficiency. However, the data in literature available at present do not allow for conclusive meta-analysis. OBJECTIVE/MATERIALS AND METHODS: A systematic review of the literature (MEDLINE-EMBASE, 01/01/2003-31/12/2013, studies with ≥4 patients, adults, non-ESRD) to highlight which patients PUF has been used in, how and with what results. RESULTS: Consideration was given to 14 papers for a total of 471 patients...
February 2015: Journal of Nephrology
https://www.readbyqxmd.com/read/25570557/a-new-on-line-electrocardiographic-records-database-and-computer-routines-for-data-analysis
#19
Carlos A Ledezma, Erika Severeyn, Gilberto Perpiñán, Miguel Altuve, Sara Wong
Gathering experimental data to test computer methods developed during a research is a hard work. Nowadays, some databases have been stored online that can be freely downloaded, however there is not a wide range of databases yet and not all pathologies are covered. Researchers with low resources are in need of more data they can consult for free. To cope with this we present an on-line portal containing a compilation of ECG databases recorded over the last two decades for research purposes. The first version of this portal contains four databases of ECG records: ischemic cardiopathy (72 patients, 3-lead ECG each), ischemic preconditioning (20 patients, 3-lead ECG each), diabetes (51 patients, 8-lead ECG each) and metabolic syndrome (25 subjects, 12-lead ECG each)...
2014: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/25564475/modulation-of-glucose-metabolism-by-the-renin-angiotensin-aldosterone-system
#20
REVIEW
Guillaume A Favre, Vincent L M Esnault, Emmanuel Van Obberghen
The renin-angiotensin-aldosterone system (RAAS) is an enzymatic cascade functioning in a paracrine and autocrine fashion. In animals and humans, RAAS intrinsic to tissues modulates food intake, metabolic rate, adiposity, insulin sensitivity, and insulin secretion. A large array of observations shows that dysregulation of RAAS in the metabolic syndrome favors type 2 diabetes. Remarkably, angiotensin-converting enzyme inhibitors, suppressing the synthesis of angiotensin II (ANG II), and angiotensin receptor blockers, targeting the ANG II type 1 receptor, prevent diabetes in patients with hypertensive or ischemic cardiopathy...
March 15, 2015: American Journal of Physiology. Endocrinology and Metabolism
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