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https://www.readbyqxmd.com/read/28926334/family-phenotypic-heterogeneity-caused-by-mitochondrial-dna-mutation-a3243g
#1
Daniela Alves, Maria Eufémia Calmeiro, Carmo Macário, Rosa Silva
Maternally inherited diabetes and deafness is a rare form of diabetes caused by a mitochondrial DNA mutation. The index case is a 55-year-old woman who was admitted with hypertrophic cardiomyopathy. She had a history of diabetes mellitus and hearing loss. The patient's mother, two brothers and two sisters also had a history of diabetes and hearing loss. This pattern suggests a maternally inherited disorder. All siblings carried the A3243G mitochondrial DNA mutation. The identification of people with monogenic forms of diabetes mellitus is a diagnostic challenge...
August 31, 2017: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28871828/eating-behaviors-and-emotional-distress-are-predicted-by-treatment-and-adverse-outcome-in-patients-with-type-2-diabetes
#2
Arnulfo González-Cantú, Leonor Mireles-Zavala, Anabel Rodríguez-Romo, Elizabeth Olavide-Aguilar, Natalia Eloisa De la Garza-Hernández, Maria Elena Romero-Ibarguengoitia
Depression and anxiety are hightly prevalent among patients with Type 2 Diabetes (T2D), however not commonly related to outcomes, treatment and comorbidities. Eating behaviors could also have an implication. To evaluate the relation between mood and eating behaviors with demographic, physical, treatment, biochemical profiles and chronic comorbidities in T2D we conducted this exploratory cross sectional study in a population from Mexico. Hospital Anxiety and Depression Scale and the Three Factor Eating Questionnaire Revised 21 (TFEQ-R21) were correlated with age, gender, blood pressure, treatment and comorbidities (nephropathy, neuropathy, retinopathy and cardiopathy)...
September 5, 2017: Psychology, Health & Medicine
https://www.readbyqxmd.com/read/28856160/mortality-and-cardiovascular-complications-in-older-complex-chronic-patients-with-type-2-diabetes
#3
J L Clua-Espuny, M A González-Henares, M L L Queralt-Tomas, W Campo-Tamayo, E Muria-Subirats, A Panisello-Tafalla, J Lucas-Noll
AIMS/INTRODUCTION: Determining the prevalence of diabetes and its cardiovascular complications and all-cause mortality in older chronic complex patients. MATERIALS AND METHODS: We carried out a multicenter retrospective study and included a randomized sample of 932 CCP people. We assessed the prevalence of diabetes according to World Health Organization criteria. Data included demographics and functional, comorbidity, cognitive, and social assessment. RESULTS: The prevalence of diabetes was 53% and average age 81...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28653161/the-post-sir-spheres-surgery-study-p4s-retrospective-analysis-of-safety-following-hepatic-resection-or-transplantation-in-patients-previously-treated-with-selective-internal-radiation-therapy-with-yttrium-90-resin-microspheres
#4
Fernando Pardo, Bruno Sangro, Rheun-Chuan Lee, Derek Manas, Rohan Jeyarajah, Vincent Donckier, Geert Maleux, Antonio D Pinna, Lourens Bester, David L Morris, David Iannitti, Pierce K Chow, Richard Stubbs, Paul J Gow, Gianluca Masi, Kevin T Fisher, Wan Y Lau, Konstantinos Kouladouros, Georgios Katsanos, Giorgio Ercolani, Fernando Rotellar, José I Bilbao, Michael Schoen
BACKGROUND: Reports show that selective internal radiation therapy (SIRT) may downsize inoperable liver tumors to resection or transplantation, or enable a bridge-to-transplant. A small-cohort study found that long-term survival in patients undergoing resection following SIRT appears possible but no robust studies on postsurgical safety outcomes exist. The Post-SIR-Spheres Surgery Study was an international, multicenter, retrospective study to assess safety outcomes of liver resection or transplantation following SIRT with yttrium-90 (Y-90) resin microspheres (SIR-Spheres(®); Sirtex)...
September 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28619533/-dyslipidemia-management-in-patients-with-high-cardiovascular-risk-in-spain-alma-study
#5
Xavier Pintó, Ferran Trias Vilagut, Joan Rius Taruella, Esther Mairal Sallán
OBJECTIVE: To assess the attitude of primary care (PCPs) and specialized care (SCPs) physicians towards the general set of patients with dyslipidemia, particularly those with cardiovascular risk factors. DESIGN: Observational, descriptive, multi-center study based on a survey. LOCATION: Different healthcare regions in Spain. PARTICIPANTS: 1,402 PCPs, and 596 SCPs. MAIN MEASUREMENTS: Physician's profile, routine practices in the management of patients with dyslipidemia...
June 12, 2017: Atencion Primaria
https://www.readbyqxmd.com/read/28595785/comparative-study-of-cardio-protective-effects-of-zinc-oxide-nanoparticles-and-zinc-sulfate-in-streptozotocin-induced-diabetic-rats
#6
Siamak Asri-Rezaei, Bahram Dalir-Naghadeh, Ali Nazarizadeh, Zahra Noori-Sabzikar
The cardio-protective effects of zinc oxide nanoparticles (Zn NPs) against diabetes-induced cardiopathy were evaluated and compared with zinc sulfate (ZnSO4). A total of 120 Wistar rats were randomly categorized as healthy and diabetic groups. Then, the 2 groups were classified in 5 subgroups. The animals received oral supplementations containing different Zn NP (ie, doses of 1, 3, and 10mg/kg) and ZnSO4 (30mg/kg) concentrations over 8 weeks. Blood and cardiac tissue samples were collected in the different time intervals and subjected to biochemical and histopathological analysis...
July 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/28561181/-the-load-of-injustice-a-longitudinal-analysis-of-the-impact-of-subjectively-perceived-income-injustice-on-the-risk-of-stress-associated-diseases-based-on-the-german-socio-economic-panel-study
#7
Claudia Boscher, Laura Arnold, Andreas Lange, Bertram Szagun
Background Income injustice is regarded as a psychosocial strain and associated with an increased risk of stress-related diseases. The physiological stress response is thereby considered as a central link. The aim of the study is to reveal the influence of subjectively perceived income injustice on stress-associated diseases, taking into consideration the load duration. Method Based on the German Socio-Economic Panel Study, data on 5,657 workers in the survey years 2005-2013 were analyzed. The dependent variable reflect the doctor's diagnosed new cases of diabetes, asthma, cardiopathy, stroke, hypertension and depression in the years 2009-2013 as an index...
May 30, 2017: Das Gesundheitswesen
https://www.readbyqxmd.com/read/28482820/the-changing-epidemiology-and-clinical-features-of-infective-endocarditis-a-retrospective-study-of-196-episodes-in-a-teaching-hospital-in-china
#8
Wan Zhu, Qian Zhang, Jingping Zhang
BACKGROUND: Infective endocarditis is an uncommon but life-threatening infectious disease. To our knowledge, current investigations of the characteristics of infective endocarditis in our region are scarce. In this study, we aimed to investigate the changes in the epidemiology and clinical features of infective endocarditis. METHODS: A retrospective analysis of clinical data was performed using 196 infective endocarditis cases diagnosed between June 2004 and December 2012 at The First Affiliated Hospital of China Medical University...
May 8, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28452100/pediatric-psoriasis-should-we-be-concerned-with-comorbidity-cross-sectional-study
#9
Awatef Kelati, Hanane Baybay, Adil Najdi, Safae Zinoune, Fatima Z Mernissi
BACKGROUND: Similarly to psoriasis in adults, recent research has linked psoriasis to several comorbidities in children. The aim of this study was therefore to describe comorbidities associated with pediatric psoriasis, to investigate their relationship with psoriasis characteristics and severity, and to perform a review of the literature. METHODS: A cross-sectional study was performed on a sample of Moroccan children with psoriasis, in 2014-2016. RESULTS: A total of 64 pediatric psoriasis patients had metabolic comorbidities in association with psoriasis; 20 children had non-metabolic comorbidities; and 76 children had no comorbidity...
April 28, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28074994/-normoglycemic-diabetic-ketoacidosis-in-pregnancy-report-of-one-case
#10
Margarita Rivas M, Pamela Belmar Z, Pilar Durruty A, Lilian Sanhueza M, Gloria López S
Normoglycemic diabetic ketoacidosis should be suspected in pregnant women presenting nausea, vomiting, abdominal pain and anorexia. We report a 39 years old woman with a 32 weeks pregnancy who sought emergency care due to hyperemesis. She was hospitalized with the following diagnoses: pregnancy hypertension syndrome, gestational diabetes, morbid obesity and poor prenatal control. The evaluation of the feto-placental unit showed perception of fetal movements, non-reactive non-stress baseline record and a biophysical profile of 6/8...
October 2016: Revista Médica de Chile
https://www.readbyqxmd.com/read/27865960/identification-of-inonotus-obliquus-polysaccharide-with-broad-spectrum-antiviral-activity-against-multi-feline-viruses
#11
Jin Tian, Xiaoliang Hu, Dafei Liu, Hongxia Wu, Liandong Qu
Inonotus obliquus polysaccharides (IOPs) are a potential drug for the prevention and treatment of cancer, cardiopathy, diabetes, AIDs, pancreatitis and other diseases. In this study, we found that IOP can act as a broad-spectrum antiviral drug against feline viruses in the in vitro experiment. Using cell models of feline calicivirus (FCV), we demonstrated that IOP treatment was capable of exhibiting anti-FCV strain F9 activity in cell-based assays and also showed low cytotoxicity. Investigation of the mechanism of action of the compound revealed that IOP treatment induces its inhibitory actions directly on virus particles through blocking viral binding/absorpting...
February 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27530514/cardioprotective-role-of-peroxisome-proliferator-activated-receptor-%C3%AE-agonist-rosiglitazone-in-a-unique-murine-model-of-diabetic-cardiopathy
#12
Suresh R Giri, Bibhuti Bhoi, Mukul R Jain, Madhumanjiri M Gatne
AIMS: Rosiglitazone (RSZ), a PPARγ agonist was potent efficacious insulin sensitizing blockbuster drug for treatment of Type 2 diabetes mellitus (T2DM) but the benefit of PPARγ activation in congestive heart failure (CHF) was controversial. The present work was planned to study the role of RSZ in diabetic cardiopathy. MAIN METHODS: Zucker fa/fa rats, the genetic model of T2DM were subjected to constriction of suprarenal abdominal aorta so that they represent a combined model of diabetes and cardiopathy...
October 1, 2016: Life Sciences
https://www.readbyqxmd.com/read/27354356/eets-and-ho-1-cross-talk
#13
REVIEW
David Sacerdoti, Paola Pesce, Marco Di Pascoli, Massimo Bolognesi
Epoxygenase-dependent metabolites of arachidonc acid, EETs and the heme-oxygenase (HO)-1/carbon monoxide/bilverdin system share similarities in their activity and mediators. They control endothelial function, dilating small arterial vessels, decrease blood pressure, protect the heart from ischemic and hypertensive cardiopathy, control renal circulation and function, promote angiogenesis and organ regeneration, oppose oxidative stress and inflammation, improve diabetes and obesity, have protective effects on the liver, and participate in portal hypertension...
September 2016: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/27316658/recipient-age-impact-on-outcome-after-cardiac-transplantation-should-it-still-be-considered-in-organ-allocation
#14
Sandro Sponga, Laura Deroma, Roberta Sappa, Daniela Piani, Andrea Lechiancole, Enrico Spagna, Vincenzo Tursi, Chiara Nalli, Ugolino Livi
OBJECTIVES: Improvement of clinical results in heart transplantation (HTx) has favoured the expansion of indication criteria towards aged population. The impact of increasing recipient age is controversial and, owing to donor shortage, the debate still remains whether HTx is justified for older patients. We analysed age as a prognostic factor at long-term after HTx and if it should be a determinant in organ allocation. METHODS: Data of 364 consecutive patients who underwent cardiac transplantation between 1999 and 2014 at the University Hospital of Udine were analysed...
October 2016: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/27254312/electrocardiographic-left-atrial-abnormalities-and-risk-of-incident-stroke-in-hypertensive-patients-with-electrocardiographic-left-ventricular-hypertrophy
#15
Peter M Okin, Hooman Kamel, Sverre E Kjeldsen, Richard B Devereux
BACKGROUND: Recent findings in population-based studies suggest that abnormal P wave terminal force in lead V1 (PTFV1), a marker of left atrial abnormalities such as fibrosis, dilatation and elevated filling pressures, is associated with incident ischemic stroke, even in the absence of atrial fibrillation. However, whether PTFV1 predicts incident stroke in hypertensive patients during blood pressure lowering has not been examined. METHODS: Risk of incident stroke was examined in relation to abnormal PTFV1 on a baseline ECG in 7778 hypertensive patients with ECG left ventricular hypertrophy, no history of atrial fibrillation, in sinus rhythm on their baseline ECG with no incident atrial fibrillation during follow-up, who were randomly assigned to losartan-based or atenolol-based treatment...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27044324/trim37-deficient-mice-recapitulate-several-features-of-the-multi-organ-disorder-mulibrey-nanism
#16
Kaisa M Kettunen, Riitta Karikoski, Riikka H Hämäläinen, Teija T Toivonen, Vasily D Antonenkov, Natalia Kulesskaya, Vootele Voikar, Maarit Hölttä-Vuori, Elina Ikonen, Kirsi Sainio, Anu Jalanko, Susann Karlberg, Niklas Karlberg, Marita Lipsanen-Nyman, Jorma Toppari, Matti Jauhiainen, J Kalervo Hiltunen, Hannu Jalanko, Anna-Elina Lehesjoki
Mulibrey nanism (MUL) is a rare autosomal recessive multi-organ disorder characterized by severe prenatal-onset growth failure, infertility, cardiopathy, risk for tumors, fatty liver, and type 2 diabetes. MUL is caused by loss-of-function mutations in TRIM37, which encodes an E3 ubiquitin ligase belonging to the tripartite motif (TRIM) protein family and having both peroxisomal and nuclear localization. We describe a congenic Trim37 knock-out mouse (Trim37(-/-)) model for MUL. Trim37(-/-) mice were viable and had normal weight development until approximately 12 months of age, after which they started to manifest increasing problems in wellbeing and weight loss...
2016: Biology Open
https://www.readbyqxmd.com/read/26913747/-clopidogrel-induced-hepatotoxicity-in-hemodialyzed-patient-a-case-report
#17
Sergio Papagni, Carmen Bonifati, Filippo Dagostino, Angelo Marco Murgo
Drug-induced liver injury is a frequent cause of acute liver failure. It may cause clinical manifestations ranging from simple alteration of the common liver function tests until more severe manifestations including encephalopathy, coagulopathy, and in many cases progressive multi-organ dysfunction. The condition, therefore, may be associated with higher morbidity and mortality as well as higher consumption of economic resources. In this paper, we present the case of a 71-year-old patient treated with hemodialysis, diabetic, with ischemic cardiopathy and severe peripheral vascular disease...
January 2016: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://www.readbyqxmd.com/read/26877521/p-208-stroke-in-the-elderly-admitted-to-the-reception-room-of-life-threatening-emergencies-study-of-prognostic-factors
#18
A Sayhi, N Mtaoua, N B Mefteh, N Ridene, A Kheli
OBJECTIFS: L'accident vasculaire cérébral (AVC) est une pathologie grave, invalidante et de plus en plus fréquente avec le vieillissement de la population. C'est l'urgence neurologique la plus fréquente mettant en jeu le pronostic vital et susceptible d'entraîner une morbi-mortalité non négligeable si la prise en charge médicale n'est pas optimale dès les premières heures. Le but de notre travail est d'analyser les aspects épidémiologiques, cliniques, tomodensitométriques et de dégager les facteurs pronostiques des AVC du sujet âgé admis à la SAUV...
December 2015: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/26877486/p-178-diuretics-prescription-and-assessment-of-practices-in-pediatric-intensive-care-unit-university-hospital-of-oran
#19
D Batouche, K Elhalimi, N Benatta, N Chaib, S Abas-Sini, Y Touhami, M A Negadi, Z Mentouri
OBJECTIFS: Les indications de prescription des diurétiques sont diverses notamment en milieu de réanimation. Elles peuvent être bien conduites sous réserve d'un monitorage de la volémie. Ce travail, a pour objectif d'évaluer l'utilisation des diurétiques en réanimation au niveau des indications de prescriptions. MéTHODES: Étude monocentrique rétrospective incluant tous les patients hospitalisés en réanimation pédiatrique sur une période de janvier 1997 à décembre 2014, chez qui une prescription des diurétiquesétait indiquée...
December 2015: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/26877401/p-098-clinical-evaluation-and-risk-factors-of-stroke-hospitalized-at-the-internal-medicine-department-of-the-university-hospital-of-sidi-bel-abbes-algeria
#20
M Chami, M Taleb, W Zahdour, S Maamar, Z Nadji, N Belhadj, F Arbia-Boudjelthia, S Benteldja, A Babou
OBJECTIFS: L'Accident Vasculaire Cérébral est un problème de santé publique en Algérie, de par sa fréquence et sa morbi-mortalité, c'est la troisième cause de décès et la première cause de handicap. Selon les dernières estimations 40 000 cas d'AVC surviennent chaque année en Algérie. Sa prise en charge souffre de beaucoup d'insuffisances en raison de la rareté des unités neurovasculaires. Le but de notre étude est de préciser le type d'AVC, les facteurs de risque, le délai d'admission et le score NIHSS des AVC hospitalisés en médecine interne...
December 2015: Annales de Cardiologie et D'angéiologie
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