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REVIEW
Quentin Perrier, Cécile Moro, Sandrine Lablanche
INTRODUCTION: Diabetes is a global health concern characterized by chronic hyperglycemia resulting from insulinopenia and/or insulin resistance. The rising prevalence of diabetes and its associated complications (ulcers, periodontitis, healing of bone defect, neuropathy, retinopathy, cardiopathy and nephropathy) necessitate innovative therapeutic approaches. Photobiomodulation (PBM), involves exposing tissues and cells to low-energy light radiation, leading to biological effects, largely via mitochondrial activation...
2024: Frontiers in Endocrinology
#2
JOURNAL ARTICLE
A M García-Prieto, Ú Verdalles, A P de José, D Arroyo, I Aragoncillo, D Barbieri, R E Camacho, M Goicoechea
INTRODUCTION: Evidence about nefroprotective effect with RAAS blockers in elderly patients with chronic kidney disease (CKD) without proteinuria is lacking. The primary outcome of our study is to evaluate the impact of RAAS blockers in CKD progression in elderly patients without proteinuria. MATERIALS AND METHODS: Multicenter open-label, randomized controlled clinical trial including patients over 65 year-old with hypertension and CKD stages 3-4 without proteinuria...
March 19, 2024: Hipertensión y Riesgo Vascular
#3
REVIEW
Rolf Teschke
Hemochromatosis represents clinically one of the most important genetic storage diseases of the liver caused by iron overload, which is to be differentiated from hepatic iron overload due to excessive iron release from erythrocytes in patients with genetic hemolytic disorders. This disorder is under recent mechanistic discussion regarding ferroptosis, reactive oxygen species (ROS), the gut microbiome, and alcohol abuse as a risk factor, which are all topics of this review article. Triggered by released intracellular free iron from ferritin via the autophagic process of ferritinophagy, ferroptosis is involved in hemochromatosis as a specific form of iron-dependent regulated cell death...
February 25, 2024: International Journal of Molecular Sciences
#4
REVIEW
Stéphanie Ibrahim, Bénédicte Gaborit, Marien Lenoir, Gwenaelle Collod-Beroud, Sonia Stefanovic
Congenital heart defects (CHDs) are the most common form of birth defects in humans. They occur in 9 out of 1000 live births and are defined as structural abnormalities of the heart. Understanding CHDs is difficult due to the heterogeneity of the disease and its multifactorial etiology. Advances in genomic sequencing have made it possible to identify the genetic factors involved in CHDs. However, genetic origins have only been found in a minority of CHD cases, suggesting the contribution of non-inherited (environmental) risk factors to the etiology of CHDs...
November 13, 2023: International Journal of Molecular Sciences
#5
JOURNAL ARTICLE
Guillaume Giudicelli, Daniel Gero, Lind Romulo, Vasu Chirumamilla, Pouya Iranmanesh, Christopher K Owen, Wayne Bauerle, Amador Garcia, Lisa Lucas, Anne-Sophie Mehdorn, Dhananjay Pandey, Abdullah Almuttawa, Francisco Cabral, Abhishek Tiwari, Virginia Lambert, Beniamino Pascotto, Celine De Meyere, Marouan Yahyaoui, Thomas Haist, Oliver Scheffel, Maud Robert, Frederiek Nuytens, Santiago Azagra, Lilian Kow, Arun Prasad, Carlos Vaz, Michel Vix, Vivek Bindal, Jan H Beckmann, David Soussi, Ramon Vilallonga, Maher El Chaar, Erik B Wilson, Arif Ahmad, Andre Teixeira, Monika E Hagen, Christian Toso, Pierre-Alain Clavien, Milo Puhan, Marco Bueter, Minoa K Jung
BACKGROUND: Whether the benefits of the robotic platform in bariatric surgery translate into superior surgical outcomes remains unclear. The aim of this retrospective study was to establish the 'best possible' outcomes for robotic bariatric surgery and compare them with the established laparoscopic benchmarks. METHODS: Benchmark cut-offs were established for consecutive primary robotic bariatric surgery patients of 17 centres across four continents (13 expert centres and 4 learning phase centres) using the 75th percentile of the median outcome values until 90 days after surgery...
January 3, 2024: British Journal of Surgery
#6
JOURNAL ARTICLE
Alain García-Olea, Ane Elorriaga, Amaia Arregui, Paula Mendoza, Abel Andrés, Roberto Sáez
BACKGROUND AND PURPOSE: Premature infarction has a high socioeconomic impact and we lack contemporary studies that analyze the characteristics associated with its development and evolution. MATERIAL AND METHODS: In an observational study on a retrospective cohort of patients younger than 46 years old, who had suffered from an infarction from June 2012 to June 2022, sociodemographic characteristics, cardiovascular and toxic risk factors, infarction characteristics, SARS-CoV-2 infection and immunization data were investigated...
2023: Archivos de Cardiología de México
#7
JOURNAL ARTICLE
Barbara Stacherl, Odile Sauzet
BACKGROUND: Experiencing the onset of a chronic disease is a serious health event impacting living conditions and wellbeing. Investigating wellbeing development and its predictors is crucial to understand how individuals adapt to chronic illnesses. This study (i) analyzed the impact of a chronic disease on wellbeing development, and (ii) explored spatial healthcare access as potential moderating factor. METHODS: Data were obtained from the German Socio-economic Panel, a nationally representative household survey...
October 6, 2023: European Journal of Public Health
#8
Takashi Hiruma, Mike Saji, Mamoru Nanasato, Mitsuaki Isobe
BACKGROUND: Mitochondrial diseases are a group of genetic disorders caused by nuclear or mitochondrial DNA gene mutations and characterized by multiorgan disorders, including cardiomyopathy. Mitochondrial cardiomyopathy is occasionally complicated by hypertrophic cardiomyopathy with/without left ventricular systolic dysfunction, dilated cardiomyopathy, and left ventricular non-compaction. In such cases, the dilated left ventricle impairs coaptation of the mitral leaflets and leads to functional mitral regurgitation...
September 2023: European Heart Journal. Case Reports
#9
JOURNAL ARTICLE
Zhike Jia, Shubin Li, Zhihua Luo, Minjun Tong, Tianyue Gao
BACKGROUND: The intrinsic damage and external hazards of smoking are major risk factors for poorer health and are recognized as a global health issue of concern in geriatric health. This study aims to assess the Dunning-Kruger effect through the influence of subjective health perceptions on smoking behavior in older adults. METHODS: This study used data from the 2018 Chinese Longitudinal Healthy Longevity Survey (N = 9,683) provided by the Center for Healthy Aging and Development Studies at Peking University...
September 4, 2023: BMC Public Health
#10
JOURNAL ARTICLE
Alexander Berry-Noronha, Luke Bonavia, Duncan Wilson, Antti Eranti, Maria Uggen Rasmussen, Ahmad Sajadieh, Fabienne Kreimer, Michael Gotzmann, Ramesh Sahathevan
OBJECTIVE: To identify ECG changes in sinus rhythm that may be used to predict subsequent development of new AF. METHOD: We identified prospective and retrospective cohort or case control studies evaluating ECG patterns from a 12-lead ECG in sinus rhythm taken in hospital or community predicting subsequent development of new AF. For each identified ECG predictor, we then identify absolute event rates and pooled risk ratios (RR) using an aggregate level random effects meta-analysis...
September 2023: European Stroke Journal
#11
JOURNAL ARTICLE
Clément Karsenty, Anthony Touafchia, Magalie Ladouceur, François Roubille, Eric Bonnefoy, Laurent Bonello, Guillaume Leurent, Bruno Levy, Sébastien Champion, Pascal Lim, Francis Schneider, Alain Cariou, Hadi Khachab, Jeremy Bourenne, Marie-France Seronde, Brahim Harbaoui, Gérald Vanzetto, Charlotte Quentin, Xavier Delabranche, Nicolas Combaret, Olivier Morel, Benoit Lattuca, Laurent Leborgne, Emmanuelle Fillippi, Edouard Gerbaud, Clara Brusq, Vanina Bongard, Nicolas Lamblin, Etienne Puymirat, Clément Delmas
BACKGROUND: Data on cardiogenic shock in adults with congenital heart disease (ACHD) are scarce. AIM: We sought to describe cardiogenic shock in ACHD patients in a nationwide cardiogenic shock registry. METHODS: From the multicentric FRENSHOCK registry (772 patients with cardiogenic shock from 49 French centres between April and October 2016), ACHD patients were compared with adults without congenital heart disease (non-ACHD). The primary outcome was defined by all-cause mortality, chronic ventricular assist device or heart transplantation at 1year...
August 2, 2023: Archives of Cardiovascular Diseases
#12
JOURNAL ARTICLE
Marta Almeria, Ignacio Alvarez, Jessica Molina-Seguin, Sarah Besora, Mariateresa Buongiorno, Silvia Romero, Laura Casas, Cristina Cano, Judith Castejon, Sonia Arribas, Jerzy Krupinski
INTRODUCTION: Neuroprotective drugs such as citicoline could improve cognitive performance and quality of life. We studied the effect of citicoline treatment and its association with Vascular Risk Factors (VRF) and APOE on cognition in patients with Subjective Cognitive Complaints (SCC) and Mild Cognitive Impairment (MCI). METHODS: This is an observational and prospective study with citicoline during 12 months follow-up. Eighty-one subjects who met criteria for SCC/MCI, aged 50-75 years with VRF were included and prescribed citicoline 1g/day...
2023: Clinical Interventions in Aging
#13
JOURNAL ARTICLE
The three-noes right-sided infective endocarditis: An unrecognized type of right-sided endocarditis.
Gonzalo Cabezón, Javier López, Isidre Vilacosta, Gilbert Habib, José María Miró, Carmen Olmos, Cristina Sarriá, Marta Hernandez-Meneses, Carlos González-Juanatey, José Ramón González-Juanatey, Jaume Llopis, Guillermo Cuervo, Carmen Sáez, Itziar Gómez, J Alberto San Román
The "3 noes right-sided infective endocarditis" (3no-RSIE: no left-sided, no drug users, no cardiac devices) was first described more than a decade ago. We describe the largest series to date to characterize its clinical, microbiological, echocardiographic and prognostic profile. Eight tertiary centers with surgical facilities participated in the study. Patients with right-sided endocarditis without left sided involvement, absence of drug use history and no intracardiac electronic devices were retrospectively included in a multipurpose database...
July 21, 2023: Medicine (Baltimore)
#14
Matheus Negri Boschiero, Nathália Mariana Santos Sansone, Fernando Augusto Lima Marson
We described the characteristics of 18 patients with coronavirus disease (COVID)-19 and X-linked disorders in a cohort of 2,066,678 Brazilian patients hospitalized due to COVID-19. The patients were diagnosed with Hemophilia B (one patient), Klinefelter syndrome [eight patients- three deaths occurred, one unrelated to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection], and Turner syndrome (nine patients- two patients died). Half of the patients with X-linked disorders and COVID-19 (9/18) were male, the age varied from 1 to 71 years, and most patients were White (9/12; six patients had missing data)...
April 28, 2023: Respiratory Investigation
#15
JOURNAL ARTICLE
Tenofovir Disoproxil Fumarate Reduces the Severity of COVID-19 in Patients with Chronic Hepatitis B.
Beatriz Mateos-Muñoz, María Buti, Inmaculada Fernández Vázquez, Marta Hernández Conde, Vanesa Bernal-Monterde, Fernando Díaz-Fontenla, Rosa María Morillas, Luisa García-Buey, Ester Badía, Mireia Miquel, Alberto Amador-Navarrete, Sergio Rodríguez-Tajes, Lucía Ramos-Merino, Antonio Madejón, Montserrat García-Retortillo, Juan Ignacio Arenas, Joaquín Cabezas, Jesús Manuel González Santiago, Conrado Fernández-Rodríguez, Patricia Cordero, Moisés Diago, Antonio Mancebo, Alberto Pardo, Manuel Rodríguez, Elena Hoyas, Jose Javier Moreno, Juan Turnes, Miguel Ángel Simón, Cristina Marcos-Fosch, Jose Luis Calleja, Rafael Bañares, Sabela Lens, Javier Garcia-Samaniego, Javier Crespo, Manuel Romero-Gomez, Francisco Gea, Enrique Rodríguez de Santiago, Santiago Moreno, Agustin Albillos
BACKGROUND AND AIMS: HIV-positive patients on tenofovir hydroxyl fumarate (TDF)/emtricitabine have a lower risk of COVID-19 and hospitalization than those given other treatments. Our aim was to analyze the severity of COVID-19 in patients with chronic hepatitis B (CHB) on TDF or entecavir (ETV). METHODS: Spanish hospital databases (n = 28) including information regarding adult CHB patients on TDF or ETV for the period February 1st to November 30th 2020 were searched for COVID-19, defined as a positive SARS-CoV-2 polymerase chain reaction, and for severe COVID-19...
February 3, 2023: Digestive Diseases and Sciences
#16
REVIEW
Khalid Saad Alharbi, Muhammad Shahid Nadeem, Obaid Afzal, Sami I Alzarea, Abdulmalik S A Altamimi, Waleed Hassan Almalki, Bismillah Mubeen, Saima Iftikhar, Luqman Shah, Imran Kazmi
Hyperglycemia is seen in approximately 68 percent of patients admitted to a medical intensive care unit (ICU). In many acute circumstances, such as myocardial infarction, brain, injury and stroke, it is an independent predictor of mortality. Hyperglycemia is induced by a mix of genetic, environmental, and immunologic variables in people with type 1 diabetes. These factors cause pancreatic beta cell death and insulin insufficiency. Insulin resistance and irregular insulin production cause hyperglycemia in type 2 diabetes patients...
December 16, 2022: Metabolites
#17
JOURNAL ARTICLE
Noemí Villén, Albert Roso-Llorach, Carlos Gallego-Moll, Marc Danes-Castells, Sergio Fernández-Bertolin, Amelia Troncoso-Mariño, Monica Monteagudo, Ester Amado, Concepción Violán
(1) Introduction: Cardiovascular disease is associated with high mortality, especially in older people. This study aimed to characterize the evolution of combined multimorbidity and polypharmacy patterns in older people with different cardiovascular disease profiles. (2) Material and methods: This longitudinal study drew data from the Information System for Research in Primary Care in people aged 65 to 99 years with profiles of cardiovascular multimorbidity. Combined patterns of multimorbidity and polypharmacy were analysed using fuzzy c-means clustering techniques and hidden Markov models...
December 13, 2022: Geriatrics
#18
JOURNAL ARTICLE
Guillermo Verdejo-Muñoz, César Gálvez-Barrón, Borja Gracia Tello, Sara Gamarra Calvo, Isabel Sanjoaquín Conde, Andrés Catena, José Ramón Blanco Ramos
BACKGROUND: In this study, we aim to evaluate microangiopathy in HIV positive patients by using capillaroscopy. To date, few studies have been published on the topic. Capillaroscopy may be a tool for early diagnosis of cardiovascular involvement in this patient population. METHODOLOGY: Cross-sectional study with HIV positive patients >18 years. The enrolment period was set from January to June 2018. The following data were collected: demographic (sex, age), laboratory tests (duration of infection, CD4 cell count, CD4:CD8 ratio, coinfection with other viruses), antiretroviral treatment, dyslipidemia, and comorbidities (active smoking, alcoholism, high blood pressure, dyslipidaemia, diabetes, cardiopathy)...
December 5, 2022: Anales del Sistema Sanitario de Navarra
#19
JOURNAL ARTICLE
Keith Zhi Xian Toh, Ming Yi Koh, Jamie S Y Ho, Kathleen Hui Xin Ong, Yong Qin Lee, Xintong Chen, Jun Tao Fang, Elliot Yeung Chong, Isis Claire Z Y Lim, Yao Hao Teo, Yao Neng Teo, Christopher Y K Chua, Yinghao Lim, Bernard P L Chan, Vijay K Sharma, Leonard L L Yeo, Ching Hui Sia, Benjamin Y Q Tan
INTRODUCTION: A patent foramen ovale (PFO) may coexist with other potential embolic sources (PESs) in patients with embolic stroke of undetermined source (ESUS), leading to difficulty in attributing the stroke to either the PFO or other PESs. We aimed to investigate the prevalence and predictors of concomitant PESs in ESUS patients with PFOs. METHODS: A retrospective cohort study was conducted in a tertiary stroke centre. Consecutive patients with ESUS and a concomitant PFO admitted between 2012 and 2021 were included in the study...
December 1, 2022: Cerebrovascular Diseases
#20
Loa Ambroise Gnaba, Kassi Anicet Adoubi, Kouakou Florent Diby, Isabelle Kouamé, Pinnin Evelyne Adjara Ouattara, Manga Diomandé, Mbe Matokoma Daniogo, Keumian Gabin Tro, Koudré Serge Armel Dakoi, Aka Roland N'Guetta
Abnormalities in the aVR lead would provide useful information on the risk of coronary heart disease. This clinical case is an illustration. Indeed, this is a 60-year-old patient, an active smoker and a former type 2 diabetic who presented with angina-like chest pain with a positive stress test. The initial electrocardiogram showed a discreet elevation of the ST segment and an aVR necrosis Q wave with mirror signs in the inferior territory. An ischemic heart disease with altered ventricular ejection fraction was objectified...
2022: Pan African Medical Journal
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