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qtc in type 2 DM

Zhongju Lu, Lloyd Lense, Mohit Sharma, Ankit Shah, Ying Luu, Lucien Cardinal, Joan Faro, Alan Kaell
Aim: To evaluate the prevalence and longitudinal changes of prolonged QTc in DM patients admitted to our community hospital, and to determine, if any, its correlation with changes of left ventricular ejection fraction (LVEF). Methods: A retrospective chart review of patients with Type 1 (T1DM) and Type 2 (T2DM) with at least two admissions during a four-year period was performed to identify QTc interval, and LVEF, as measured on transthoracic echocardiogram. Changes in QTc and LVEF between patient hospital admissions were compared...
March 2017: Journal of Community Hospital Internal Medicine Perspectives
Alptug Tokatli, Fethi Kiliçaslan, Metin Alis, Omer Yiginer, Mehmet Uzun
BACKGROUND: Type 2 diabetes mellitus (T2DM) is associated with increased risk of malignant ventricular arrhythmias. Cardiac electrical inhomogeneity may be the leading cause of the increased arrhythmic risk in patients with T2DM. The peak and the end of the T wave (Tp-e) interval and associated Tp-e/QT ratio are promising measures of ventricular repolarization indicating transmural dispersion of repolarization. The aim of this study was to assess ventricular repolarization in patients with T2DM by using Tp-e interval, Tp-e/QT ratio and Tp-e/corrected QT interval (QTc) ratio...
March 2016: Endocrinology and Metabolism
SaeHeum Song, Nobuko Matsushima, James Lee, Jeanne Mendell
No abstract text is available yet for this article.
January 2016: Journal of Clinical Pharmacology
Zafar A Arif, Imran Ali Shaikh, Naila Masood
INTRODUCTION: Diabetes mellitus (DM) is a clinical syndrome characterized by hyperglycemia due to absolute or relative insulin deficiency. Cardiovascular autonomic neuropathy invokes potentially life threatening outcomes especially in poorly controlled diabetic patients. However, there is scarcity of epidemiological data for CAN in poorly controlled type 2 diabetic patients in Pakistan. OBJECTIVE: The objective of this study is to assess the frequency of cardiovascular autonomic neuropathy (CAN) in patients with poorly controlled type 2 diabetes mellitus in Pakistan...
November 2014: Indian Heart Journal
Henrique Tria Bianco, Maria Cristina Izar, Henrique Andrade Fonseca, Rui Manuel Póvoa, José Francisco Saraiva, Adriana Forti, Paulo Cesar B V Jardim, Luis Introcaso, Juan Yugar-Toledo, Hermes Tóros Xavier, André Arpad Faludi, Francisco A H Fonseca
BACKGROUND: Patients with diabetes are in extract higher risk for fatal cardiovascular events. OBJECTIVE: To evaluate major predictors of mortality in subjects with type 2 diabetes. METHODS: A cohort of 323 individuals with type 2 diabetes from several regions of Brazil was followed for a long period. Baseline electrocardiograms, clinical and laboratory data obtained were used to determine hazard ratios (HR) and confidence interval (CI) related to cardiovascular and total mortality...
October 2014: Arquivos Brasileiros de Cardiologia
Jowita Biernawska, Mariusz Kaczmarczyk, Katarzyna Kotfis, Miłosław Cnotliwy, Małgorzata Zegan-Barańska, Agnieszka Zukowska, Arkadiusz Greczan, Maciej Zukowski
BACKGROUND: The occurrence of cardiovascular diseases in the group of patients undergoing vascular surgery because of abdominal aorta aneurysm is very high. Endovascular procedures are regarded as hemodynamically safer for the patients. The aim of this study was to compare the changes in electrophysiological, hemodynamic, and metabolic parameters depending on the type of operation, using invasive hemodynamic monitoring and Holter electrocardiography recording. METHODS: A prospective, observational, nonrandomized study was conducted to compare dynamic changes of electrophysiological parameters (dominant rhythm, arrhythmia, corrected QT interval (QTc), invasive blood pressure, electrolytes, and acid-base balance in defined points during perioperative time in 2 groups: vascular prosthesis implantation group (91 patients) and stent-graft implantation group (83 patients)...
October 2014: Annals of Vascular Surgery
M Hanefeld, X Ganz, C Nolte
Hypoglycemia is a common and potentially life-threatening adverse effect of inappropriate diabetes treatment. Typical cardiac complications are ischemia with angina pectoris, myocardial infarction, stroke and arrhythmias, such as atrial fibrillation (AF), ventricular tachycardia and heart failure. Elderly multimorbid patients with type 2 diabetes and polypharmacy and/or cardiac autonomous neuropathy represent a very high risk group for cardiovascular complications associated with hypoglycemia. Targets for glycemic control have to be adapted to the risk of hypoglycemia with a priority of stable glucose homeostasis without rapid fluctuations...
May 2014: Herz
Fahrettin Uysal, Evren Ozboyaci, Ozlem Bostan, Halil Saglam, Evren Semizel, Ergun Cil
BACKGROUND: The aim of this study was to identify the sensitivity of electrocardiogram (ECG) in early diagnosis of cardiac autonomic function disorder in children with type 1 diabetes mellitus. METHODS: A total of 150 children and adolescents with type 1 diabetes mellitus were enrolled between June 2009 and June 2010, as well as 100 age- and sex-matched healthy control children. Twelve-lead ECG was done in all cases and heart rate, QT and QTc interval, dispersion of P wave (Pd), and of QT (QTd) and QTc interval (QTcd) were measured...
October 2014: Pediatrics International: Official Journal of the Japan Pediatric Society
Borje Darpo, Meijian Zhou, Jessica Matthews, Hui Zhi, Malcolm A Young, Caroline Perry, Rickey R Reinhardt
INTRODUCTION: Albiglutide, a selective once-weekly glucagon-like peptide-1 receptor agonist, is being developed for the treatment of type 2 diabetes mellitus. Albiglutide's effect on cardiac repolarization (QTc interval) was assessed in a randomized, double-blind, placebo-controlled, parallel-group study in healthy subjects with a nested crossover comparison for moxifloxacin. METHODS: Subjects were randomized to albiglutide (n = 85) or placebo (n = 89) and received injections of 30 mg albiglutide or placebo on Days 1 and 8 and 50 mg albiglutide or placebo on Days 15, 22, 29, and 36...
June 2014: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
Robert A Kloner, Mary E Hines, Scarlett Geunes-Boyer
Chronic stable angina (CSA) impairs patient quality of life, is associated with increased patient mortality, and is a prominent symptom of coronary artery disease (CAD), the latter being prevalent worldwide in patients. Currently, therapeutic options for patients with CSA include β-blockers, calcium channel blockers, nitrates, and ranolazine. Ranolazine is a first-in-class piperazine derivative that inhibits the late inward sodium current in cardiac cells and is considered an effective and safe option for treating patients with CSA...
November 2013: Postgraduate Medicine
Yan-Ling He, Yiming Zhang, Jing-He Yan, Wei Zhou, Steven Komjathy, Ann Taylor
BACKGROUND: QT interval prolongation is associated with an increased risk of potentially fatal ventricular tachycardias, including torsade de pointes. Regulatory guidance recommends the "thorough QT/QTc" (TQT) study as the gold standard for assessing the propensity of novel nonantiarrhythmic drugs to delay cardiac repolarization. An opportunity exists, however, to use high-quality electrocardiogram (ECG) data from first-in-man trials as an exploratory and complementary approach to gain early insight into potential risk of QT prolongation...
December 2013: International Journal of Clinical Pharmacology and Therapeutics
Wenhui Zhang, Ronald Smulders, Anura Abeyratne, Albert Dietz, Walter Krauwinkel, Takeshi Kadokura, James Keirns
BACKGROUND: Ipragliflozin, a potent, selective sodium glucose cotransporter 2 inhibitor, is in development for the treatment of type 2 diabetes mellitus. The International Conference on Harmonisation recommends that the safety investigation of new drugs include characterization of each agent's effects on the QT/QTc interval. OBJECTIVE: The goal of this study was to assess the effect on cardiac repolarization (QTc interval) of repeated oral dosing of ipragliflozin at therapeutic (100 mg/d) and supratherapeutic (600 mg/d) levels in healthy subjects...
August 2013: Clinical Therapeutics
Petros Thomakos, Stavros Liatis, Stavroula Kalopita, Ioannis Vlahodimitris, Chryssoula Stathi, Nicholas Katsilambros, Nicholas Tentolouris, Konstantinos Makrilakis
Aims. Aim of the study was to evaluate the effect of smoking on autonomic nervous system (ANS) activity and QTc interval duration in patients with Type 2 diabetes mellitus (T2DM). Methods. A total of 70 patients with T2DM (35 chronic smokers, 35 nonsmokers) treated with oral antidiabetic medications underwent continuous ECG Holter monitoring for 24 hours and analysis of time- and frequency-domain measures of heart rate variability (HRV). HRV over short time was also assessed using the deep breathing test. In addition, baroreflex sensitivity (BRS) was evaluated using the spontaneous sequence method...
2013: International Journal of Endocrinology
Donatella Cortelazzi, Annamaria Marconi, Marco Guazzi, Maurizio Cristina, Barbara Zecchini, Annamaria Veronelli, Claudio Cattalini, Alessandro Innocenti, Giovanna Bosco, Antonio E Pontiroli
An increased prevalence of female sexual dysfunction (FSD) has been reported in women with diabetes mellitus (DM). Our aim was to evaluate correlates (psychological, cardiovascular, and neurophysiologic) of FSD in DM women without chronic diabetic complications. Female Sexual Function Index (FSFI), Beck Depression Inventory (BDI), Michigan Diabetic Neuropathy Index (DNI), and the symptoms of diabetic neuropathy (SDN) questionnaires, metabolic variables, endothelial vascular function (flow-mediated dilation, FMD), echocardiography, and electromyography were studied...
December 2013: Acta Diabetologica
Amr M Abbas, Hussein F Sakr
High fat diet (HFD) is a common cause of metabolic syndrome and type 2 diabetes mellitus. Published data showed that HFD and subsequent dyslipidemia are major triggers for oxidative stress. Forty-eight male Sprague-Dawley rats, weighing 170-200 g, were divided into six groups: control, control with vitamin E (100 mg/kg/day, i.p.), control with simvastatin (SIM) (10 mg/kg of body weight/day), HFD, HFD with vitamin E, and HFD with SIM. Standard and high cholesterol diets were given for 15 weeks and SIM and vitamin E were added in the last 4 weeks...
December 2013: Journal of Physiology and Biochemistry
K Fagher, M Löndahl
AIMS/HYPOTHESIS: The increased all-cause mortality in patients with chronic diabetic foot ulcers cannot fully be explained by traditional cardiovascular risk factors. The significance of heart-rate-corrected QT (QTc) prolongation, a finding often seen in these patients, is unknown. Recently, the importance of metabolic control and hypoglycaemia has been discussed. The aim of this study was to evaluate the impact of different HbA1c levels and QTc prolongation on all-cause mortality in the high-risk population of patients with type 2 diabetes mellitus and foot ulcers...
May 2013: Diabetologia
Xiang Li, Hui Ren, Zhang-rong Xu, Yan-jun Liu, Xiao-pin Yang, Jian-qin Liu
OBJECTIVES: The aim of this study was to evaluate the prevalence and the risk factors of prolonged QTc interval among Chinese patients with type 2 diabetes. METHODS: The retrospective study included 3156 outpatients from the Diabetes Centre, the 306th Hospital of PLA, during the period from September 2003 to June 2010. QT interval was measured manually in the 12-lead conventional electrocardiogram. The QT interval corrected for heart rate (QTc) was calculated using Bazett's formula...
2012: Experimental Diabetes Research
Xiao-Wei Ma, Xiao-Hui Guo, Xin-Hua Xiao, Li-Xin Guo, Xiao-Feng Lv, Quan-Min Li, Yan Gao
OBJECTIVES: To evaluate the plasma atherosclerotic biomarkers in patients with type 2 diabetes mellitus (T2DM) and arteriosclerosis obliteran (ASO) when treated with Probucol plus Cilostazol in combination and individually. METHODS: In this open-label study, patients aged 40-75 years were randomized to receive conventional therapy alone, or with Cilostazol 100 mg bid, or with Probucol 250 mg bid, or with both in combination. Endpoints included changes in plasma biomarker and safety at 12 weeks...
September 2012: Journal of Geriatric Cardiology: JGC
A Dzudie, S-P N Choukem, A K Adam, A P Kengne, P Gouking, M Dehayem, F Kamdem, M S Doualla, H A Joko, M E Lobe, Y M Mbouende, H Luma, J C Mbanya, S Kingue
AIM: This study assessed the prevalence and determinants of electrocardiographic abnormalities in a group of type 2 diabetes patients recruited from two referral centres in Cameroon. METHODS: A total of 420 patients (49% men) receiving chronic diabetes care at the Douala General and Yaoundé Central hospitals were included. Electrocardiographic abnormalities were investigated, identified and related to potential determinants, with logistic regressions. RESULTS: The mean age and median duration of diagnosis were 56...
November 2012: Cardiovascular Journal of Africa
Haji Khan Khoharo, Abdul Waheed Halepoto
OBJECTIVE: To evaluate the QTc-interval, heart rate variability and postural hypotension in predicting cardiac autonomic neruopathy (CAN) in type 2 diabetes mellitus (DM) patients METHODS: The comparative cross-sectional study was conducted in the Department of Medicine, Muhammad Medical College Hospital, Mirpurkhas, Sindh, from September 2008 to December 2009. A total of 186 type-2 diabetes mellitus patients with a QTc value of > 440 ms were studied. The QT interval was measured on electrocardiographic (ECG) recordings...
April 2012: JPMA. the Journal of the Pakistan Medical Association
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