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ischaemia modified albumin

F Facchin, S Catalani, E Bianconi, D De Pasquale, S Stea, A Toni, S Canaider, A Beraudi
Metal-on-metal (MoM) hip prostheses are known to release chromium and cobalt (Co), which negatively affect the health status, leading to prosthesis explant. Albumin (ALB) is the main serum protein-binding divalent transition metals. Its binding capacity can be affected by gene mutations or modification of the protein N-terminal region, giving the ischaemia-modified albumin (IMA). This study evaluated ALB, at gene and protein level, as marker of individual susceptibility to Co in MoM patients, to understand whether it could be responsible for the different management of this ion...
May 20, 2016: Human & Experimental Toxicology
Suchismita Panda, Sushanta Kumar Jena, Rachita Nanda, Manaswini Mangaraj, Parsuram Nayak
INTRODUCTION: Hepatic injury of varied aetiology may progress to Acute Liver Failure (ALF). Compromised microcirculation is thought to be a deciding factor of hepatic hypoxia may be involved in disease progression that needs early detection. Ischaemia markers like serum Ischaemia- modified albumin (IMA), ALT-LDH ratio and ALT-LDH index have been suggested for its detection at early stage. AIM: To find out the association of Ischaemia markers like serum IMA, ALT-LDH ratio and ALT-LDH index in acute hepatic injury cases...
April 2016: Journal of Clinical and Diagnostic Research: JCDR
Mustafa Ozturk, Ugur Keskin, Ozlem Ozturk, Mustafa Ulubay, İbrahim Alanbay, Aytekin Aydin, Müfit Cemal Yenen
We assessed the serum levels of gamma-glutamyl transferase (GGT), high-sensitivity C-reactive protein (hsCRP) and ischaemia-modified albumin (IMA) in patients with polycystic ovary syndrome (PCOS). Fifty-three patients with PCOS were included in our study along with 40 women with no PCOS as the control group. The patients were divided according to their body mass index (BMI). GGT levels were significantly higher in the women with PCOS than the women in the control group (p < 0.05). They were also significantly higher in the PCOS women who were normoweight and overweight than the normoweight and overweight women in the control group (p < 0...
May 16, 2016: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
Firat Uygur, Hakan Tanriverdi, Murat Can, Tacettin Ornek, Fatma Erboy, Bulent Altinsoy, Figen Atalay, Murat Damar, Furuzan Kokturk, Meltem Tor
The aim of the present study was to evaluate the impact of obstructive sleep apnoea syndrome (OSAS) and the effects of nasal continuous positive airway pressure (CPAP) on circulating ischaemia-modified albumin (IMA) concentrations. The study included 97 newly diagnosed OSAS patients and 30 nonapnoeic controls. Blood samples were obtained in the morning after polysomnography. After 3 months of CPAP treatment, 31 patients with moderate-severe OSAS were reassessed for serum IMA concentrations. Significantly higher serum IMA concentrations were measured in the OSAS group than in the control group [0...
2016: Mediators of Inflammation
Anthony J Bastin, Nathan Davies, Eric Lim, Greg J Quinlan, Mark J Griffiths
BACKGROUND AND OBJECTIVE: N-acetylcysteine has been used to treat a variety of lung diseases, where is it thought to have an antioxidant effect. In a randomized placebo-controlled double-blind study, the effect of N-acetylcysteine on systemic inflammation and oxidative damage was examined in patients undergoing lung resection, a human model of acute lung injury. METHODS: Eligible adults were randomized to receive preoperative infusion of N-acetylcysteine (240 mg/kg over 12 h) or placebo...
January 2016: Respirology: Official Journal of the Asian Pacific Society of Respirology
L Chandrashekar, G R Krishna Kumarit, M Rajappa, G Revathy, M Munisamy, D M Thappa
Psoriasis is a T-helper-1 (Th1)/Th17-mediated chronic inflammatory skin disease, characterised by hyperproliferation of keratinocytes. Psoriasis and cardiovascular disease share similar pathogenic mechanisms such as vascular endothelial cell dysfunction, oxidative stress and metabolic syndrome. 25-hydroxy vitamin D is an immune-regulatory hormone, with the ability to reduce cellular proliferation in psoriasis. Ischaemia-modified albumin (IMA) is a marker of oxidative stress. This study examined 25-hydroxy vitamin D, IMA and high-sensitivity C-reactive protein (hs-CRP) levels in patients with psoriasis, in comparison with healthy controls and their possible association with disease severity...
2015: British Journal of Biomedical Science
Fabrice Joulia, Mathieu Coulange, Frederic Lemaitre, Agnelys Desplantes, Guillaume Costalat, Laurie Bruzzese, Frederic Franceschi, Bruno Barberon, Nathalie Kipson, Yves Jammes, Régis Guieu
Ischaemia-modified albumin (IMA) is a marker of the release of reactive oxygen species (ROS) during hypoxaemia. In elite divers, breath-hold induces ROS production. Our aim was to evaluate the kinetics of IMA serum levels during apnea. Twenty breath-hold divers were instructed to perform a submaximal static breath-hold. Twenty non-diver subjects served as controls. Blood samples were collected at rest, every minute, at the end of breath-hold, and 10 min after recovery. The IMA level increased after 1 min of breath-hold (p < 0...
June 2015: Canadian Journal of Physiology and Pharmacology
M Kiseli, G S Caglar, A Y Gursoy, E D Ozdemir, H Ozdemir, R T Seker, S Demirtas
The purpose of this study was to investigate whether levels of fetal hypoxia markers, S100 and ischaemia modified albumin (IMA) change in cases of intrauterine growth restriction (IUGR). This case-control study included 15 intrauterine growth restricted fetuses and 20 age-matched controls. During delivery of the fetuses, cord blood and maternal blood S100 and IMA levels were studied. The fetal weight and umbilical cord pH values of IUGR fetuses were significantly lower than the control group. The mean maternal and umbilical cord blood values of S100 and IMA were similar in the two groups...
May 2015: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
Volkan Temi, Erdem Okay, Abdullah Güneş, Turgay Simşek, Mustafa Cekmen, Umit Bilgili, Yeşim Gürbüz
BACKGROUND: It is well known that mucosal changes and alterations in liver function occur in the experimental obstructive jaundice model. AIMS: We aimed to evaluate the effect of resveratrol on obstructive jaundice-induced changes in the small bowel mucosa and liver using ischaemia-modified albumin as a marker of oxidative damage. STUDY DESIGN: Animal experimentation. METHODS: The study used a rodent experimental model of obstructive jaundice, including a sham group (1), a control group (2), and a study group (3)...
March 2014: Balkan Medical Journal
O Karadeniz, I Mendilcioglu, S Ozdem, M Ozekinci, C Y Sanhal, G Uzun, M Sakinci, M Simsek
Intrauterine growth restriction (IUGR) is one of the most common problems in obstetrics. Ischaemia-modified albumin (IMA), a product deriving from albumin as a result of the modification by oxidative free radicals in response to hypoxia, was previously used as a marker of ischaemia in acute coronary syndrome. We performed this study to determine whether umbilical venous IMA levels are associated with IUGR. A total of 40 pregnancies with IUGR were compared with 40 of normal fetal development. Blood samples were obtained from the umbilical vein after delivery...
January 2015: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
Christoph Liebetrau, Holger M Nef, Oliver Dörr, Luise Gaede, Jedrzej Hoffmann, Astrid Hahnel, Andreas Rolf, Christian Troidl, Karl J Lackner, Till Keller, Christian W Hamm, Helge Möllmann
OBJECTIVE: To determine the release kinetics of different biomarkers with potential as novel early ischaemic biomarkers in patients with acute coronary syndrome (ACS); it is difficult to establish the detailed release kinetics in patients with acute myocardial infarction (AMI). METHODS: We analysed the release kinetics of soluble fms-like tyrosine kinase (sFlt-1), ischaemia modified albumin (IMA), and heart-type fatty acid binding protein (hFABP) in patients with hypertrophic obstructive cardiomyopathy who were undergoing transcoronary ablation of septal hypertrophy (TASH), a procedure mimicking AMI...
April 2014: Heart: Official Journal of the British Cardiac Society
A Caliskan, C Yavuz, O Karahan, Sinan Demirtas, S Yazici, O Guclu, B Mavitas
BACKGROUND: Acute mesenteric ischaemia is an emergency condition that requires urgent and expeditious diagnosis and immediate surgical or medical intervention. The initial hours are critical for the recovery of the affected bowel segment. Thus, its clinic diagnostic biomarkers are important when it comes to reducing mortality and morbidity rates. METHODS: Twenty-four male Sprague-Dawley rats were included in the study. The rats were divided into three equal groups...
May 2014: Perfusion
Dilek Omür, Servet Özden Hacivelioglu, Hüseyin Oguzalp, Berna Uyan, Hasan Ali Kiraz, Can Duman, Funda Kirtay Tütüncüler, Volkan Hanci
OBJECTIVE: Ischaemia-modified albumin (IMA) is an early marker for various ischaemic events, including cardiac ischaemia. This study determined variations in IMA levels during caesarean section, performed under general anaesthesia or with combined spinal epidural anaesthesia. METHODS: Full-term, healthy pregnant women were allocated to undergo caesarean section, using either general anaesthesia or combined spinal epidural anaesthesia. IMA and albumin levels were measured in maternal serum samples taken immediately prior to caesarean section and 30 min into the procedure, as well as from serum taken from cord blood after double clamping...
August 2013: Journal of International Medical Research
Sangita M Patil, M P Banker, Ramchandra K Padalkar, Abhijit P Pathak, Sonali S Bhagat, Rahul A Ghone, Anjali S Phatake
BACKGROUND: An early identification of the patients with the Acute Coronary Syndrome (ACS) is of prime importance, due to the associated very high mortality. Only about 22% of the patients who present at the emergency cardiology care centres with chest pain, have coronary disease. Ischaemia modified albumin has already been licensed by the US Food and Drug Administration for the diagnosis of suspected myocardial ischaemia. AIM: The goal of the present study was to assess the diagnostic value of serum ischaemia modified albumin and to compare it with sensitive cardiac troponin I in patients with the acute coronary syndromes like unstable angina and acute myocardial infarction...
May 2013: Journal of Clinical and Diagnostic Research: JCDR
Zehra Karataş, Tamer Baysal, Fatih Şap, Hayrullah Alp, Idris Mehmetoğlu
INTRODUCTION: Ischaemia-modified albumin, a novel biochemical marker for tissue ischaemia, was found to be associated with oxidative stress. The purpose of this study was to assess the role of ischaemia-modified albumin in the diagnosis of acute rheumatic fever and also to evaluate the ischaemia-modified albumin levels in children with heart valve disease. METHODS: The study groups, aged 5-18 years, consisted of 128 individuals - 40 with acute rheumatic fever, 35 with congenital heart valve disease, 33 with chronic rheumatic heart disease, and 20 healthy control subjects...
June 2014: Cardiology in the Young
Gilles Gravier, Jean Guillaume Steinberg, Pierre Jean Lejeune, Stephane Delliaux, Regis Guieu, Yves Jammes
We hypothesized that the changes in blood oxidant/antioxidant status during incremental maximal cycling exercise could affect the motor drive to leg muscles. Indeed, the oxygen free radicals activate the metabosensitive muscle afferents which are suspected to elicit an adaptive motor response delaying fatigue. Fifteen healthy subjects performed an incremental cycling exercise reaching the maximal oxygen uptake (VO2) during which venous blood was repeatedly sampled to measure a marker of lipid peroxidation (TBARS), an antioxidant (reduced ascorbic acid, RAA), and the ischaemia-modified albumin (IMA)...
May 1, 2013: Respiratory Physiology & Neurobiology
S Goodacre, P Thokala, C Carroll, J W Stevens, J Leaviss, M Al Khalaf, P Collinson, F Morris, P Evans, J Wang
BACKGROUND: Current practice for suspected acute coronary syndrome (ACS) involves troponin testing 10-12 hours after symptom onset to diagnose myocardial infarction (MI). Patients with a negative troponin can be investigated further with computed tomographic coronary angiography (CTCA) or exercise electrocardiography (ECG). OBJECTIVES: We aimed to estimate the diagnostic accuracy of early biomarkers for MI, the prognostic accuracy of biomarkers for major adverse cardiac adverse events (MACEs) in troponin-negative patients, the diagnostic accuracy of CTCA and exercise ECG for coronary artery disease (CAD) and the prognostic accuracy of CTCA and exercise ECG for MACEs in patients with suspected ACS...
2013: Health Technology Assessment: HTA
Grażyna Sygitowicz, Jadwiga Janas, Sławomir Białek, Jerzy Pręgowski, Lukasz Pera, Dariusz Sitkiewicz
BACKGROUND: Approximately 40-60% of patients with acute coronary syndrome (ACS) have normal cardiac troponin I (cTnI) concentrations on admission. Ischaemia modified albumin (IMA) has been suggested as a new biomarker of myocardial ischaemia. METHODS: A total of 43 patients presenting with symptoms suggestive of ACS but with normal (< 0.1 μg/L) cTnI concentrations and 45 healthy subjects were studied. The patients from the study group were divided into two groups: STEMI (n = 28) and NSTEMI (n = 15)...
March 2013: Scandinavian Journal of Clinical and Laboratory Investigation
Philip J Dutton, Lynne K Warrander, Stephen A Roberts, Giovanna Bernatavicius, Louise M Byrd, David Gaze, Josh Kroll, Rebecca L Jones, Colin P Sibley, J Frederik Frøen, Alexander E P Heazell
BACKGROUND: Maternal perception of reduced fetal movement (RFM) is associated with increased risk of stillbirth and fetal growth restriction (FGR). RFM is thought to represent fetal compensation to conserve energy due to insufficient oxygen and nutrient transfer resulting from placental insufficiency. OBJECTIVE: To identify predictors of poor perinatal outcome after maternal perception of reduced fetal movements (RFM). DESIGN: Prospective cohort study...
2012: PloS One
Arzu Dursun, Nurullah Okumus, Aysegul Zenciroglu
Perinatal asphyxia is a significant cause of perinatal morbidity and mortality worldwide. It is estimated that around 23% of all newborn deaths are caused by birth asphyxia. Each year, between four and nine million newborns develop birth asphyxia worldwide, according to the World Health Organization (WHO). Therefore, despite major advances in monitoring and knowledge of fetal and neonatal physiology and development, perinatal asphyxia remains a serious condition that causes significant mortality and long-term morbidity...
November 2012: Journal of Maternal-fetal & Neonatal Medicine
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