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mean platelet volume in ACS

Michał Kowara, Kajetan Grodecki, Zenon Huczek, Dominika Puchta, Katarzyna Paczwa, Bartosz Rymuza, Karol Zbroński, Krzysztof J Filipiak, Grzegorz Opolski
BACKGROUND: Platelets' role in pathophysiology of acute coronary syndromes (ACS) is undeniable, but precise relationships between platelet activity and treatment outcomes are matter of continuant investigation. Among platelet indices, mean platelet volume (MPV) has proven to be valuable predicting factor in cardiac patients. However platelet distribution width (PDW) is reported to be more specific marker of platelet reactivity. Thus, application of PDW in risk stratification of ACS treatment is up-to-date subject of research...
October 7, 2016: Kardiologia Polska
Xuan Wang, Xiao-Lei Xu, Xi-Ming Li, Ru Zhao, Xu Yang, Hong-Liang Cong
OBJECTIVE: To explore diagnostic performance of mean platelet volume (MPV) for acute myocardial infarction (AMI) of patients with acute coronary syndrome (ACS). METHODS: We compared MPV and other indicators of 1,524 patients with ACS. Among them, 880 patients were diagnosed with AMI, 344 were diagnosed with unstable angina pectoris and 350 were the control group. RESULTS: The level of MPV in ACS group was significantly higher than the control group (9...
August 2016: American Journal of the Medical Sciences
Takashi Kubo, Yasushi Ino, Yoshiki Matsuo, Yasutsugu Shiono, Takeyoshi Kameyama, Takashi Yamano, Yosuke Katayama, Akira Taruya, Tsuyoshi Nishiguchi, Keisuke Satogami, Kuninobu Kashiyama, Makoto Orii, Akio Kuroi, Tomoyuki Yamaguchi, Atsushi Tanaka, Takeshi Hozumi, Takashi Akasaka
BACKGROUND: Prasugrel is a new-generation thienopyridine antiplatelet agent that provides more consistent and prompt platelet inhibition than clopidogrel. The aim of this study was to compare in-stent thrombus inhibition effect of pretreatment with prasugrel and clopidogrel by using optical coherence tomography (OCT) immediately after percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS). METHODS: We performed OCT immediately after PCI in 108 ACS patients pretreated with either prasugrel (n=51) or clopidogrel (n=57)...
May 6, 2016: Journal of Cardiology
Mohammad Reza Dehghani, Yousef Rezaei, Sanam Fakour, Nasim Arjmand
BACKGROUND AND OBJECTIVES: Leukocyte and platelet have been found to be associated with metabolic syndrome (MetS). We aimed to determine the usefulness of a novel marker named white blood cell count to mean platelet volume ratio (WMR) for predicting outcomes of non-ST elevation acute coronary syndrome (NSTE-ACS) with or without MetS. SUBJECTS AND METHODS: A total of 331 NSTE-ACS individuals (60±12.5 years, 57.4% male) were enrolled and followed for a median of 24 months...
March 2016: Korean Circulation Journal
Jarosław Wasilewski, Piotr Desperak, Michał Hawranek, Aneta Ciślak, Tadeusz Osadnik, Łukasz Pyka, Marcin Gawlita, Kamil Bujak, Jacek Niedziela, Michał Krawczyk, Mariusz Gąsior
BACKGROUND: Mean platelet volume (MPV) is a simple and reliable indicator of platelet size that correlates with platelet activation and their ability to aggregate. We studied the predictive value of MPV in patients with non-ST-segment elevation myocardial infarction (NSTEMI) treated with percutaneous coronary intervention (PCI). METHODS: We analyzed the consecutive records of 1001 patients who were hospitalized due to NSTEMI at our center. The primary end point was a composite end point that included the rates of all-cause death, non-fatal myocardial infarction, and acute coronary syndrome (ACS) driven revascularization at 12 months...
July 2016: Platelets
Mehmet Balli, Hakan Taşolar, Mustafa Çetin, Caglar Emre Cagliyan, Mehmet Yavuz Gözükara, Mahmut Yilmaz, Zafer Elbasan, Murat Cayli
INTRODUCTION: Despite major advances in stent technology and antithrombotic therapy, the development of stent thrombosis continues to be a major problem in patients who have undergone percutaneous coronary intervention (PCI). Although a few studies have investigated the relationship between early stent thrombosis and platelet activity, the relationship between acute stent thrombosis (AST) (within the first 24 h) and platelet indices is unclear. AIM: We investigated the relationship between AST development and platelet indices in acute coronary syndrome patients...
2015: Postępy W Kardiologii Interwencyjnej, Advances in Interventional Cardiology
Alessia Fabbri, Rossella Marcucci, Anna Maria Gori, Betti Giusti, Rita Paniccia, Daniela Balzi, Alessandro Barchielli, Serafina Valente, Cristina Giglioli, Rosanna Abbate, Gian Franco Gensini
INTRODUCTION: Limited data are available on the natural history of high on treatment platelet reactivity (HPR) by arachidonic acid and ADP - markers of unfavorable prognosis in acute coronary syndrome patients -. MATERIAL AND METHODS: In a cohort of acute coronary syndrome male patients (n=101), we evaluated the time-course of HPR by ADP (platelet aggregation by 10μM ADP≥70%) and arachidonic acid (platelet aggregation by 1mmol arachidonic acid≥20%) measuring platelet function in the acute phase (T0), at 6months (T1) and 1year (T2)...
September 2015: Thrombosis Research
Mohammad Reza Dehghani, Yousef Rezaei
No abstract text is available yet for this article.
2015: Cardiology Journal
Murat Yuksel, Abdulkadir Yildiz, Murat Cayli
No abstract text is available yet for this article.
2015: Cardiology Journal
Monica Verdoia, Patrizia Pergolini, Roberta Rolla, Matteo Nardin, Lucia Barbieri, Alon Schaffer, Giorgio Bellomo, Paolo Marino, Harry Suryapranata, Giuseppe De Luca
OBJECTIVE: High on-treatment platelet reactivity (HRPR) is associated with a two- to ninefold increased risk of recurrent ischemic events among patients receiving dual antiplatelet therapy (DAPT) for coronary artery disease. However, its determinants are still poorly understood. The aim of the present study was to assess the impact of mean platelet volume (MPV) on platelet reactivity in patients receiving DAPT after an acute coronary syndrome or PCI. METHODS: Patients treated with DAPT (acetylsalicylic acid [ASA] and clopidogrel or ticagrelor) were scheduled for platelet function assessment at 30 - 90 days post-discharge...
2015: Expert Opinion on Pharmacotherapy
Zuzana Motovska, Martina Ondrakova, Frantisek Bednar, Jiri Knot, Jaroslav Ulman, Marek Maly
OBJECTIVE: The present study aimed to compare characteristics related to selection of a P2Y₁₂ antagonist, investigate initiation of therapy with new-generation drugs, and identify predictors of high on-treatment platelet reactivity (HTPR) in patients with acute coronary syndrome treated with stent percutaneous coronary intervention (PCI). METHODS AND RESULTS: Data from 589 patients in the LAPCOR (Laboratory AntiPlatelet efficacy and Clinical Outcome Registry; ClinicalTrials...
June 2015: Thrombosis Research
Mohammad Reza Dehghani, Yousef Rezaei, Leila Taghipour-Sani
BACKGROUND: Total white blood cell (WBC) count and mean platelet volume have previously been shown to predict outcomes in acute coronary syndrome (ACS) patients. In this prospective study, we sought to determine the prognostic value of baseline WBC count to mean platelet volume ratio (WMR) in patients with non-ST elevation acute coronary syndrome (NSTE-ACS). METHODS: A total of 490 patients with NSTE-ACS were prospectively enrolled. The relationship between baseline WMR and major adverse cardiovascular events (MACE) incidence was assessed during a mean follow-up of 330...
2015: Cardiology Journal
Mohammad Reza Dehghani, Leila Taghipour-Sani, Yousef Rezaei, Rahim Rostami
OBJECTIVE: Acute coronary syndrome (ACS) is a challenging issue in cardiovascular medicine. Given platelet role in atherothrombosis, we sought to determine whether platelet indices can be used as diagnostic tests for patients who suffered from an acute chest discomfort. METHODS: We prospectively enrolled 862 patients with an acute chest pain and 184 healthy matched controls. They were divided into four groups: 184 controls, 249 of non-ACS, 421 of unstable angina (UA), and 192 of myocardial infarction (MI) cases...
November 2014: Indian Heart Journal
Martin Jakl, Jaroslav Maly
No abstract text is available yet for this article.
January 2015: Anatolian Journal of Cardiology
Agnieszka Obrebska, Jan Kowalski
Recently, attention has been paid to anemia (decreased number of red blood cells in peripheral blood and less than the normal quantity of hemoglobin) apart from the traditional methods used in determining prognosis in patients with acute cardiac syndrome (ACS). Thrombocytopenia and increased mean platelet volume (MPV) are listed among other--yet simple--laboratory blood tests which have prognostic significance in patients with ACS. In ACS patients it is necessary to distinguish between anemia which is established on admission to hospital (chronic anemia) and that acquired in the hospital (HAA)...
November 2014: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
A V Mazurov, I T Ziuriaev, S G Khaspekova, V V Iakushkin, O V Sirotkina, M Ia Ruda
AIM: To study factors influencing platelet aggregation in patients with acute coronary syndrome (ACS). SUBJECTS AND METHODS: The investigation enrolled 147 patients with ACS. Their blood was sampled on days 1, 3-5, and 8-12 days after the onset of ACS. All the patients received acetylsalicylic acid (ASA) 300 mg on day 1, then 100 mg/day and clopidogrel 300-600 mg on day 1, then 75-150 mg/day. Platelet aggregation was analyzed in 65 patients on day 1 after ASA intake, but prior to clopidogrel therapy...
2014: Terapevticheskiĭ Arkhiv
Randheer Pal, Rajeev Bagarhatta, Sandhya Gulati, Monika Rathore, Nidhi Sharma
BACKGROUND: Platelets and their activity have a crucial role in acute coronary events. Larger platelets are enzymatically and metabolically more active and have a higher potential thrombotic ability as compared with smaller platelets. OBJECTIVES: The aim of this study is to investigate whether there is an association between mean platelet volume (MPV) measurement and cardiac Troponin I( cTn I ) in patients admitted with a suspected diagnosis of ACS and to assess the potential diagnostic efficiency of MPV in the diagnostic workup for ACS...
August 2014: Journal of Clinical and Diagnostic Research: JCDR
Alparslan Kurtul, Mikail Yarlioglues, Sani Namik Murat, İbrahim Etem Celik, Muhammed Bora Demircelik, Adil Hakan Ocek, Mustafa Duran, Gokhan Ergun, Mustafa Cetin, Ender Ornek
Chronic total occlusion (CTO) in a noninfarct-related artery (non-IRA) is an independent predictor of mortality in acute coronary syndrome (ACS). Mean platelet volume (MPV) and serum uric acid (SUA) are associated with cardiovascular events in ACS. We investigated the relationship between the presence of non-IRA-CTO with MPV and SUA levels in patients with ACS. Patients (n = 1024) who underwent urgent coronary angiography for ACS were included in this study. Blood samples were drawn on admission. Patients were categorized into 2 groups: non-IRA-CTO (-) and non-IRA-CTO (+)...
July 2015: Angiology
Xiaowei Niu, Cuiling Yang, Yiming Zhang, Hengliang Zhang, Yali Yao
Our aim was to evaluate the incremental predictive value of adding mean platelet volume (MPV) to the Global Registry of Acute Coronary Events (GRACE) risk score. The MPV and GRACE score were determined on admission in 509 consecutive patients with acute coronary syndrome (ACS). Six-month mortality or nonfatal myocardial infarction (MI) was the study end point. Overall, 61 (12%) patients reached the combined end point. Cox multivariate analysis showed that an elevated MPV was an independent predictor of 6-month mortality or MI in patients with ACS...
May 2015: Angiology
M A Berny-Lang, C E Darling, A L Frelinger, M R Barnard, C S Smith, A D Michelson
INTRODUCTION: Early and accurate identification of acute coronary syndrome (ACS) vs. noncardiac chest pain in patients presenting to the emergency department (ED) is problematic and new diagnostic markers are needed. Previous studies reported that elevated mean platelet volume (MPV) is associated with ACS and predictive of cardiovascular risk. MPV is closely related to the immature platelet fraction (IPF), and recent studies have suggested that IPF may be a more sensitive marker of ACS than MPV...
February 2015: International Journal of Laboratory Hematology
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