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mean platelet volume in ACS

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https://www.readbyqxmd.com/read/28774187/mean-platelet-volume-to-lymphocyte-ratio-as-a-novel-marker-for-severity-and-complexity-of-coronary-atherosclerosis-in-patients-with-acute-coronary-syndrome
#1
Alparslan Kilic, Alparslan Kurtul
The thromboinflammatory process plays an important role in the pathophysiology of acute coronary syndrome (ACS). Recently, the mean platelet volume-to-lymphocyte ratio (MPVLR) has been suggested as a prognostic marker in patients with ACS. We assessed the association of MPVLR with the severity and complexity of coronary atherosclerosis in patients with ACS. A total of 1782 patients undergoing urgent coronary angiography were enrolled. The SYNTAX score (SXscore) was calculated for each patient. Patients were divided into 2 groups: low SXscore (<23) and intermediate-to-high SXscore (≥23)...
January 1, 2017: Angiology
https://www.readbyqxmd.com/read/28609750/association-of-plasma-cd40l-with-acute-chest-syndrome-in-sickle-cell-anemia
#2
Vanessa Tonin Garrido, Laura Sonzogni, Siana Nkya Mtatiro, Fernando F Costa, Nicola Conran, Swee Lay Thein
Platelet activation and platelet-derived cytokines contribute to the vascular inflammation and increased thrombotic activity known to occur in patients with sickle cell anemia (SCA). CD40 ligand (CD40L), a platelet-associated pro-inflammatory molecule that promotes endothelial cell activation, is elevated in the circulation of SCA patients. We sought to evaluate the association of CD40L and inflammation with sickle-related clinical complications and laboratory variables in SCA patients. Soluble CD40L, thrombospondin (TSP)-1 and tumor necrosis factor (TNF)-α were determined in the platelet-poor plasma of healthy individuals and steady-state SCA patients by ELISA...
June 10, 2017: Cytokine
https://www.readbyqxmd.com/read/28412719/combined-measurement-of-factor-xiii-and-d-dimer-is-helpful-for-differential-diagnosis-in-patients-with-suspected-pulmonary-embolism
#3
Ning Tang, Ziyong Sun, Dengju Li, Jun Yang, Shiyu Yin, Qing Guan
BACKGROUND: D-dimer has been used to rule out pulmonary embolism (PE). Based on previous reports of decreased concentrations of coagulation factor XIII (FXIII) in venous thromboembolism, and no change in FXIII concentration in patients with acute cardiovascular disease, we evaluated the benefit of simultaneously measuring D-dimer and FXIII concentrations for diagnosing PE. METHODS: In this prospective single-center study, we enrolled 209 patients initially suspected of having PE, and measured their D-dimer and FXIII concentrations...
April 17, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28337385/comparison-of-ticagrelor-and-high-dose-clopidogrel-on-the-platelet-functions-in-patients-with-inadequate-response-to-clopidogrel
#4
Xinshun Gu, Xianghua Fu, Yanbo Wang, Wenhui Zhang, Weize Fan, Yunfa Jiang, Guozhen Hao, Qing Miao, Yi Li, Wei Zhi
OBJECTIVE: To evaluate the effects of ticagrelor and high-dose clopidogrel on the platelet functions in patients with inadequate response to clopidogrel. METHODS: In this prospective, randomized and controlled study, patients who had been diagnosed as acute coronary syndrome (ACS) with inadequate response to clopidogrel in the Second Hospital of Hebei Medical University from July 2015 to June 2016 were enrolled. Inadequate response to clopidogrel was defined as absolute reduction of platelet aggregation rate (PAR) <30% or PAR >70%...
2017: American Journal of Cardiovascular Disease
https://www.readbyqxmd.com/read/28260757/diagnostic-importance-of-platelet-in-patients-with-acute-coronary-syndrome-admitted-in-mymensingh-medical-college-hospital
#5
M A Islam, N I Siddiqui, M S Begum, A S Bhuiyan, M A Rahman, S U Ahammed
This cross sectional descriptive study was carried out in the Department of Cardiology, Mymensingh Medical College Hospital from July 2015 to December 2015, included 50 patients admitted with acute coronary syndrome diagnosed on the basis of history, typical anginal type of chest pain, characteristic electrocardiographic changes and increased cardiac biomarkers. Platelet count (PC), Mean platelet volume (MPV) and platelet distribution width (PDW) were measured using automated hematological analyzer and compared them with 50 age and sex matched healthy controls...
January 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/27814786/usefulness-of-mean-platelet-volume-to-predict-significant-coronary-artery-disease-in-patients-with-non-st-elevation-acute-coronary-syndromes
#6
Tuncay Taskesen, Harsimran Sekhon, Igor Wroblewski, Mikhail Goldfarb, Muhammad B Ahmad, Quang T Nguyen, Ibtihaj A M Fughhi, Adi Gidron, Shahriar Dadkhah
Acute coronary syndrome (ACS) is characterized by unstable plaque with thrombotic process involving central role of platelets. The diagnosis and prediction of significant coronary artery disease (CAD) in non-ST-elevation ACS (NSTE-ACS) can be challenging. The central role of platelets in acute atherothrombosis in NSTE-ACS spurred appreciable interest in the diagnostic and predictive role of platelet activity. Mean platelet volume (MPV) is one of the most promising laboratory markers in patients with CAD. This retrospective study was designed to investigate the diagnostic and predictive value of high MPV levels in patients with NSTE-ACS with significant CAD...
January 15, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/27714719/platelet-distribution-width-predicts-left-ventricular-dysfunction-in-patients-with-acute-coronary-syndromes-treated-with-percutaneous-coronary-intervention
#7
Michał Kowara, Kajetan Grodecki, Zenon Huczek, Dominika Puchta, Katarzyna Paczwa, Bartosz Rymuza, Karol Zbroński, Krzysztof J Filipiak, Grzegorz Opolski
BACKGROUND: The role of platelets in the pathophysiology of acute coronary syndromes (ACS) is undeniable, but precise relationships between platelet activity and treatment outcomes are a matter of continuant investigation. Among platelet indices, mean platelet volume (MPV) has proven to be a valuable predicting factor in cardiac patients. However, platelet distribution width (PDW) is reported to be a more specific marker of platelet reactivity. Thus, application of PDW in risk stratification of ACS treatment is an up-to-date subject of research...
2017: Kardiologia Polska
https://www.readbyqxmd.com/read/27524214/diagnostic-value-of-mean-platelet-volume-combined-with-troponin-i-for-acute-coronary-syndrome
#8
Xuan Wang, Xiao-Lei Xu, Xi-Ming Li, Ru Zhao, Xu Yang, Hong-Liang Cong
OBJECTIVE: To explore diagnostic performance of mean platelet volume (MPV) for acute myocardial infarction (AMI) of patients with acute coronary syndrome (ACS). METHODS: We compared MPV and other indicators of 1,524 patients with ACS. Among them, 880 patients were diagnosed with AMI, 344 were diagnosed with unstable angina pectoris and 350 were the control group. RESULTS: The level of MPV in ACS group was significantly higher than the control group (9...
August 2016: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/27160709/reduction-of-in-stent-thrombus-immediately-after-percutaneous-coronary-intervention-by-pretreatment-with-prasugrel-compared-with-clopidogrel-an-optical-coherence-tomography-study
#9
COMPARATIVE STUDY
Takashi Kubo, Yasushi Ino, Yoshiki Matsuo, Yasutsugu Shiono, Takeyoshi Kameyama, Takashi Yamano, Yosuke Katayama, Akira Taruya, Tsuyoshi Nishiguchi, Keisuke Satogami, Kuninobu Kashiyama, Makoto Orii, Akio Kuroi, Tomoyuki Yamaguchi, Atsushi Tanaka, Takeshi Hozumi, Takashi Akasaka
BACKGROUND: Prasugrel is a new-generation thienopyridine antiplatelet agent that provides more consistent and prompt platelet inhibition than clopidogrel. The aim of this study was to compare in-stent thrombus inhibition effect of pretreatment with prasugrel and clopidogrel by using optical coherence tomography (OCT) immediately after percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS). METHODS: We performed OCT immediately after PCI in 108 ACS patients pretreated with either prasugrel (n=51) or clopidogrel (n=57)...
February 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/27014354/white-blood-cell-count-to-mean-platelet-volume-ratio-is-a-prognostic-factor-in-patients-with-non-st-elevation-acute-coronary-syndrome-with-or-without-metabolic-syndrome
#10
Mohammad Reza Dehghani, Yousef Rezaei, Sanam Fakour, Nasim Arjmand
BACKGROUND AND OBJECTIVES: Leukocyte and platelet have been found to be associated with metabolic syndrome (MetS). We aimed to determine the usefulness of a novel marker named white blood cell count to mean platelet volume ratio (WMR) for predicting outcomes of non-ST elevation acute coronary syndrome (NSTE-ACS) with or without MetS. SUBJECTS AND METHODS: A total of 331 NSTE-ACS individuals (60±12.5 years, 57.4% male) were enrolled and followed for a median of 24 months...
March 2016: Korean Circulation Journal
https://www.readbyqxmd.com/read/26939525/prognostic-implications-of-mean-platelet-volume-on-short-and-long-term-outcomes-among-patients-with-non-st-segment-elevation-myocardial-infarction-treated-with-percutaneous-coronary-intervention-a-single-center-large-observational-study
#11
Jarosław Wasilewski, Piotr Desperak, Michał Hawranek, Aneta Ciślak, Tadeusz Osadnik, Łukasz Pyka, Marcin Gawlita, Kamil Bujak, Jacek Niedziela, Michał Krawczyk, Mariusz Gąsior
BACKGROUND: Mean platelet volume (MPV) is a simple and reliable indicator of platelet size that correlates with platelet activation and their ability to aggregate. We studied the predictive value of MPV in patients with non-ST-segment elevation myocardial infarction (NSTEMI) treated with percutaneous coronary intervention (PCI). METHODS: We analyzed the consecutive records of 1001 patients who were hospitalized due to NSTEMI at our center. The primary end point was a composite end point that included the rates of all-cause death, non-fatal myocardial infarction, and acute coronary syndrome (ACS) driven revascularization at 12 months...
July 2016: Platelets
https://www.readbyqxmd.com/read/26677364/relationship-of-platelet-indices-with-acute-stent-thrombosis-in-patients-with-acute-coronary-syndrome
#12
Mehmet Balli, Hakan Taşolar, Mustafa Çetin, Caglar Emre Cagliyan, Mehmet Yavuz Gözükara, Mahmut Yilmaz, Zafer Elbasan, Murat Cayli
INTRODUCTION: Despite major advances in stent technology and antithrombotic therapy, the development of stent thrombosis continues to be a major problem in patients who have undergone percutaneous coronary intervention (PCI). Although a few studies have investigated the relationship between early stent thrombosis and platelet activity, the relationship between acute stent thrombosis (AST) (within the first 24 h) and platelet indices is unclear. AIM: We investigated the relationship between AST development and platelet indices in acute coronary syndrome patients...
2015: Postępy W Kardiologii Interwencyjnej, Advances in Interventional Cardiology
https://www.readbyqxmd.com/read/26190692/a-time-course-study-of-high-on-treatment-platelet-reactivity-in-acute-coronary-syndrome-male-patients-on-dual-antiplatelet-therapy
#13
Alessia Fabbri, Rossella Marcucci, Anna Maria Gori, Betti Giusti, Rita Paniccia, Daniela Balzi, Alessandro Barchielli, Serafina Valente, Cristina Giglioli, Rosanna Abbate, Gian Franco Gensini
INTRODUCTION: Limited data are available on the natural history of high on treatment platelet reactivity (HPR) by arachidonic acid and ADP - markers of unfavorable prognosis in acute coronary syndrome patients -. MATERIAL AND METHODS: In a cohort of acute coronary syndrome male patients (n=101), we evaluated the time-course of HPR by ADP (platelet aggregation by 10μM ADP≥70%) and arachidonic acid (platelet aggregation by 1mmol arachidonic acid≥20%) measuring platelet function in the acute phase (T0), at 6months (T1) and 1year (T2)...
September 2015: Thrombosis Research
https://www.readbyqxmd.com/read/26120080/response-to-the-letter-to-the-editor-the-prognostic-value-of-white-blood-cell-count-to-mean-platelet-volume-ratio-in-patients-with-acute-coronary-syndrome
#14
LETTER
Mohammad Reza Dehghani, Yousef Rezaei
No abstract text is available yet for this article.
2015: Cardiology Journal
https://www.readbyqxmd.com/read/26119813/the-prognostic-value-of-white-blood-cell-count-to-mean-platelet-volume-ratio-in-patients-with-acute-coronary-syndrome
#15
LETTER
Murat Yuksel, Abdulkadir Yildiz, Murat Cayli
No abstract text is available yet for this article.
2015: Cardiology Journal
https://www.readbyqxmd.com/read/26067422/mean-platelet-volume-and-high-residual-platelet-reactivity-in-patients-receiving-dual-antiplatelet-therapy-with-clopidogrel-or-ticagrelor
#16
Monica Verdoia, Patrizia Pergolini, Roberta Rolla, Matteo Nardin, Lucia Barbieri, Alon Schaffer, Giorgio Bellomo, Paolo Marino, Harry Suryapranata, Giuseppe De Luca
OBJECTIVE: High on-treatment platelet reactivity (HRPR) is associated with a two- to ninefold increased risk of recurrent ischemic events among patients receiving dual antiplatelet therapy (DAPT) for coronary artery disease. However, its determinants are still poorly understood. The aim of the present study was to assess the impact of mean platelet volume (MPV) on platelet reactivity in patients receiving DAPT after an acute coronary syndrome or PCI. METHODS: Patients treated with DAPT (acetylsalicylic acid [ASA] and clopidogrel or ticagrelor) were scheduled for platelet function assessment at 30 - 90 days post-discharge...
2015: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/25917561/selection-of-p2y12-antagonist-treatment-initiation-and-predictors-of-high-on-treatment-platelet-reactivity-in-a-real-world-registry
#17
Zuzana Motovska, Martina Ondrakova, Frantisek Bednar, Jiri Knot, Jaroslav Ulman, Marek Maly
OBJECTIVE: The present study aimed to compare characteristics related to selection of a P2Y₁₂ antagonist, investigate initiation of therapy with new-generation drugs, and identify predictors of high on-treatment platelet reactivity (HTPR) in patients with acute coronary syndrome treated with stent percutaneous coronary intervention (PCI). METHODS AND RESULTS: Data from 589 patients in the LAPCOR (Laboratory AntiPlatelet efficacy and Clinical Outcome Registry; ClinicalTrials...
June 2015: Thrombosis Research
https://www.readbyqxmd.com/read/25733319/white-blood-cell-count-to-mean-platelet-volume-ratio-as-a-novel-non-invasive-marker-predicting-long-term-outcomes-in-patients-with-non-st-elevation-acute-coronary-syndrome
#18
COMPARATIVE STUDY
Mohammad Reza Dehghani, Yousef Rezaei, Leila Taghipour-Sani
BACKGROUND: Total white blood cell (WBC) count and mean platelet volume have previously been shown to predict outcomes in acute coronary syndrome (ACS) patients. In this prospective study, we sought to determine the prognostic value of baseline WBC count to mean platelet volume ratio (WMR) in patients with non-ST elevation acute coronary syndrome (NSTE-ACS). METHODS: A total of 490 patients with NSTE-ACS were prospectively enrolled. The relationship between baseline WMR and major adverse cardiovascular events (MACE) incidence was assessed during a mean follow-up of 330...
2015: Cardiology Journal
https://www.readbyqxmd.com/read/25634396/diagnostic-importance-of-admission-platelet-volume-indices-in-patients-with-acute-chest-pain-suggesting-acute-coronary-syndrome
#19
Mohammad Reza Dehghani, Leila Taghipour-Sani, Yousef Rezaei, Rahim Rostami
OBJECTIVE: Acute coronary syndrome (ACS) is a challenging issue in cardiovascular medicine. Given platelet role in atherothrombosis, we sought to determine whether platelet indices can be used as diagnostic tests for patients who suffered from an acute chest discomfort. METHODS: We prospectively enrolled 862 patients with an acute chest pain and 184 healthy matched controls. They were divided into four groups: 184 controls, 249 of non-ACS, 421 of unstable angina (UA), and 192 of myocardial infarction (MI) cases...
November 2014: Indian Heart Journal
https://www.readbyqxmd.com/read/25550247/prognostic-value-of-mean-platelet-volume-in-patients-after-acute-coronary-syndrome
#20
EDITORIAL
Martin Jakl, Jaroslav Maly
No abstract text is available yet for this article.
January 2015: Anatolian Journal of Cardiology
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