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https://www.readbyqxmd.com/read/28651296/early-discharge-hospital-at-home
#1
REVIEW
Daniela C Gonçalves-Bradley, Steve Iliffe, Helen A Doll, Joanna Broad, John Gladman, Peter Langhorne, Suzanne H Richards, Sasha Shepperd
BACKGROUND: Early discharge hospital at home is a service that provides active treatment by healthcare professionals in the patient's home for a condition that otherwise would require acute hospital inpatient care. This is an update of a Cochrane review. OBJECTIVES: To determine the effectiveness and cost of managing patients with early discharge hospital at home compared with inpatient hospital care. SEARCH METHODS: We searched the following databases to 9 January 2017: the Cochrane Effective Practice and Organisation of Care Group (EPOC) register, Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, Embase, CINAHL, and EconLit...
June 26, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28651224/patterns-of-everyday-functioning-in-preschool-children-born-preterm-and-at-term
#2
Anna Karin Andersson, Lene Martin, Katarina Strand Brodd, Lena Almqvist
BACKGROUND/AIM: Children born preterm are at risk of neonatal complications but the long-term consequences for everyday functioning is not well known. The study aimed to identify patterns of everyday functioning in preschool children born preterm and at term in relation to perinatal data, neonatal risk factors, behaviour, and socioeconomic status. Registry data and data from parent rated questionnaires were collected for 331 children. METHOD: A person-oriented approach with a cluster analysis was used...
June 23, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/28651012/the-economic-burden-of-human-papillomavirus-related-precancers-and-cancers-in-sweden
#3
Ellinor Östensson, Maria Silfverschiöld, Lennart Greiff, Christine Asciutto, Johan Wennerberg, Marie-Louise Lydryp, Ulf Håkansson, Pär Sparén, Christer Borgfeldt
BACKGROUND: High-risk (HR) human papillomavirus (HPV) infection is an established cause of malignant disease. We used a societal perspective to estimate the cost of HR HPV-related cervical, vulvar, vaginal, anal, and penile precancer and cancer, and oropharyngeal cancer in Sweden in 2006, 1 year before HPV vaccination became available in the country. MATERIALS AND METHODS: This prevalence-based cost-of-illness study used diagnosis-specific data from national registries to determine the number of HR HPV-related precancers and cancers...
2017: PloS One
https://www.readbyqxmd.com/read/28650844/long-term-persistence-of-hcv-ns5a-resistance-associated-substitutions-after-treatment-with-the-hcv-ns5a-inhibitor-ledipasvir-without-sofosbuvir
#4
David Wyles, Alessandra Mangia, Wendy Cheng, Stephen Shafran, Christian Schwabe, Wen Ouyang, Charlotte Hedskog, John McNally, Diana M Brainard, Brian P Doehle, Evguenia Svarovskaia, Michael D Miller, Hongmei Mo, Hadas Dvory-Sobol
BACKGROUND: Data on persistence of NS5A resistance associated substitutions (RASs) may have implications for resistance testing approaches and selection of initial and retreatment strategies. METHODS: Long-term persistence of NS5A RASs in HCV genotype (GT) 1 infected subjects (n=76) who did not achieve sustained virologic response after receiving ledipasvir (LDV) without sofosbuvir (SOF) and were subsequently enrolled in an ongoing 3-year follow-up registry study was investigated by population or deep sequencing...
June 26, 2017: Antiviral Therapy
https://www.readbyqxmd.com/read/28650415/videolaryngoscopy-versus-fiber-optic-intubation-through-a-supraglottic-airway-in-children-with-a-difficult-airway-an-analysis-from-the-multicenter-pediatric-difficult-intubation-registry
#5
Nicholas E Burjek, Akira Nishisaki, John E Fiadjoe, H Daniel Adams, Kenneth N Peeples, Vidya T Raman, Patrick N Olomu, Pete G Kovatsis, Narasimhan Jagannathan, Agnes Hunyady, Adrian Bosenberg, See Tham, Daniel Low, Paul Hopkins, Chris Glover, Olutoyin Olutoye, Peter Szmuk, John McCloskey, Nicholas Dalesio, Rahul Koka, Robert Greenberg, Scott Watkins, Vikram Patel, Paul Reynolds, Maria Matuszczak, Ranu Jain, Samia Khalil, David Polaner, Jennifer Zieg, Judit Szolnoki, Kumar Sathyamoorthy, Brad Taicher, N Ricardo Riveros Perez, Solmaletha Bhattacharya, Tarun Bhalla, Paul Stricker, Justin Lockman, Jorge Galvez, Mohamed Rehman, Britta Von Ungern-Sternberg, David Sommerfield, Codruta Soneru, Franklin Chiao, Martina Richtsfeld, Kumar Belani, Lina Sarmiento, Sam Mireles, Guelay Bilen Rosas, Raymond Park, James Peyton
BACKGROUND: The success rates and related complications of various techniques for intubation in children with difficult airways remain unknown. The primary aim of this study is to compare the success rates of fiber-optic intubation via supraglottic airway to videolaryngoscopy in children with difficult airways. Our secondary aim is to compare the complication rates of these techniques. METHODS: Observational data were collected from 14 sites after management of difficult pediatric airways...
June 23, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28650358/the-volume-outcome-relationship-in-deceased-donor-kidney-transplantation-and-implications-for-regionalization
#6
Andrew S Barbas, Martin J Dib, Aparna S Rege, Deepak S Vikraman, Debra L Sudan, Stuart J Knechtle, John E Scarborough
OBJECTIVE: The aim of this study was to investigate the volume-outcome relationship in kidney transplantation by examining graft and patient outcomes using standardized risk adjustment (observed-to-expected outcomes). A secondary objective was to examine the geographic proximity of low, medium, and high-volume kidney transplant centers in the United States. SUMMARY OF BACKGROUND DATA: The significant survival benefit of kidney transplantation in the context of a severe shortage of donor organs mandates strategies to optimize outcomes...
July 22, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28650254/proteomics-to-predict-the-response-to-tumour-necrosis-factor-%C3%AE-inhibitors-in-rheumatoid-arthritis-using-a-supervised-cluster-analysis-based-protein-score
#7
Bvj Cuppen, Rde Fritsch-Stork, I Eekhout, W de Jager, A C Marijnissen, Jwj Bijlsma, M Custers, J M van Laar, Fpjg Lafeber, Pmj Welsing
OBJECTIVE: In rheumatoid arthritis (RA), it is of major importance to identify non-responders to tumour necrosis factor-α inhibitors (TNFi) before starting treatment, to prevent a delay in effective treatment. We developed a protein score for the response to TNFi treatment in RA and investigated its predictive value. METHOD: In RA patients eligible for biological treatment included in the BiOCURA registry, 53 inflammatory proteins were measured using xMAP® technology...
June 26, 2017: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/28649953/clinical-restenosis-and-its-predictors-after-implantation-of-everolimus-eluting-bioresorbable-vascular-scaffolds-results-from-the-gabi-r-registry
#8
Julinda Mehilli, Stephan Achenbach, Jochen Woehrle, Moritz Baquet, Thomas Riemer, Thomas Muenzel, Holger Nef, Christoph Naber, Gert Richardt, Ralf Zahn, Tommaso Gori, Till Neumann, Johannes Kastner, Axel Schmermund, Christian Hamm
AIMS: To assess clinical restenosis and its predictors after implantation bioresorbable vascular scaffolds (BVS) in everyday practice in the large scale German-Austrian ABSORB Registry (GABI-R). METHODS AND RESULTS: Between November 2013 and January 2016, 3264 patients underwent BVS implantion in 93 centers of GABI-R. At 6-month follow-up, 24 patients experienced clinically-indicated target lesion revascularization (cTLR) unrelated to BVS thrombosis (cumulative incidence 0...
June 27, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28649938/epidemiology-and-survival-of-cervical-cancer-in-the-french-west-indies-data-from-the-martinique-cancer-registry-2002-2011
#9
K Melan, E Janky, J Macni, S Ulric-Gervaise, M-J Dorival, J Veronique-Baudin, C Joachim
BACKGROUND: The Caribbean ranks seventh among world regions most affected by cervical cancer. Social health inequalities, such as differences in access to screening services, engender disparities in incidence and mortality between low- and middle-income countries and industrialized countries. The French National Cancer Plan 2014-2019 focuses on reducing inequalities in cervical cancer. OBJECTIVE: The aim of this study was to describe the geographical distribution and overall survival of cervical cancer, based on data from a population-based cancer registry in Martinique (French West-Indies)...
2017: Global Health Action
https://www.readbyqxmd.com/read/28649912/comparative-effectiveness-of-rituximab-relative-to-ifn-%C3%AE-or-glatiramer-acetate-in-relapsing-remitting-ms-from-the-swedish-ms-registry
#10
Tim Spelman, Thomas Frisell, Fredrik Piehl, Jan Hillert
OBJECTIVE: To compare treatment effectiveness and persistence in relapsing-remitting multiple sclerosis patients who initiated rituximab versus glatiramer acetate (GA) or interferon-beta (IFN-β). METHODS: A total of 461 patients from the Swedish MS registry in the rituximab arm were propensity score matched on a 1:2 basis with 922 patients from the IFN-β/GA comparator, between April 2005 and November 2015. Annualised relapse rate (ARR) was compared using the Poisson method...
June 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28649802/punctal-occlusion-for-dry-eye-syndrome
#11
REVIEW
Ann-Margret Ervin, Andrew Law, Andrew D Pucker
BACKGROUND: Dry eye syndrome is a disorder of the tear film that is associated with symptoms of ocular discomfort. Punctal occlusion is a mechanical treatment that blocks the tear drainage system in order to aid in the preservation of natural tears on the ocular surface. OBJECTIVES: To assess the effects of punctal plugs versus no punctal plugs, different types of punctal plugs, and other interventions for managing dry eye. SEARCH METHODS: We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (which contains the Cochrane Eyes and Vision Trials Register) (2016, Issue 11), MEDLINE Ovid (1946 to 8 December 2016), Embase...
June 26, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28649759/impact-of-intravenous-thrombolysis-on-recanalization-rates-in-patients-with-stroke-treated-with-bridging-therapy
#12
L Mueller, F Pult, J Meisterernst, M R Heldner, M-L Mono, R Kurmann, M Buehlmann, U Fischer, H P Mattle, M Arnold, P Mordasini, J Gralla, G Schroth, M El-Koussy, S Jung
BACKGROUND AND PURPOSE: Randomized controlled trials have shown that bridging endovascular therapy (EVT) after intravenous thrombolysis (IVT) therapy improves outcome in patients with stroke with large-artery anterior circulation stroke compared with IVT alone. It remains unknown whether IVT adds any benefit to EVT in these patients. The aim of this study was to assess recanalization rates and thrombus dislocation before initiation of EVT in patients receiving bridging therapy. METHODS: All patients in the Bernese stroke registry (2008-2015) in whom bridging therapy was considered were included in this analysis...
June 25, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28649732/impact-of-medicaid-disenrollment-in-tennessee-on-breast-cancer-stage-at-diagnosis-and-treatment
#13
Wafa W Tarazi, Cathy J Bradley, Harry D Bear, David W Harless, Lindsay M Sabik
BACKGROUND: States routinely may consider rollbacks of Medicaid expansions to address statewide economic conditions. To the authors' knowledge, little is known regarding the effects of public insurance contractions on health outcomes. The current study examined the effects of the 2005 Medicaid disenrollment in Tennessee on breast cancer stage at the time of diagnosis and delays in treatment among nonelderly women. METHODS: The authors used Tennessee Cancer Registry data from 2002 through 2008 and estimated a difference-in-difference model comparing women diagnosed with breast cancer who lived in low-income zip codes (and therefore were more likely to be subject to disenrollment) with a similar group of women who lived in high-income zip codes before and after the 2005 Medicaid disenrollment...
June 26, 2017: Cancer
https://www.readbyqxmd.com/read/28649642/disparities-in-contralateral-prophylactic-mastectomy-use-among-women-with-early-stage-breast-cancer
#14
Younji Kim, Anne Marie McCarthy, Mirar Bristol, Katrina Armstrong
Contralateral prophylactic mastectomy use has increased over the past decades among women with early-stage breast cancer. Racial differences in contralateral prophylactic mastectomy use are well described, but with unclear causes. This study examined contralateral prophylactic mastectomy use among black and white women and the contribution of differences in perceived risk to differences in use. We surveyed women diagnosed with early-stage unilateral breast cancer between ages 41-64 in Pennsylvania and Florida between 2007-2009 to collect data on breast cancer treatment, family history, education, income, insurance, and perceived risk...
2017: NPJ Breast Cancer
https://www.readbyqxmd.com/read/28649416/educational-intervention-to-reduce-disease-related-to-sub-optimal-basic-hygiene-in-rwanda-initial-evaluation-and-feasibility-study
#15
Margaret A Stone, Hormisdas Ndagijimana
BACKGROUND: Despite a global reduction in morbidity related to sub-optimal water, sanitation and hygiene, the incidence of such diseases remains a significant problem in sub-Saharan Africa. This study aimed to initially assess the potential effectiveness (primarily in terms of impact on morbidity) of a simple educational intervention delivered in Rwanda. Additionally, we sought to explore feasibility relating to the practicality of evaluating and implementing this type of intervention in a low- and middle-income country...
2018: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/28649294/randomised-controlled-trial-of-a-baked-egg-intervention-in-young-children-allergic-to-raw-egg-but-not-baked-egg
#16
Merryn Netting, Michael Gold, Patrick Quinn, Adaweyah El-Merhibi, Irmeli Penttila, Maria Makrides
BACKGROUND: Consumption of baked egg by raw egg allergic children is associated with immune changes suggesting development of tolerance. However, causation has not been tested using a double blind randomized controlled trial (RCT). We aimed to compare clinical and immunological outcomes after baked egg (BE) consumption in young BE tolerant egg allergic children. METHODS: In a double blind RCT, BE tolerant egg allergic children consumed 10 g BE (1.3 g protein) 2 to 3 times per week for 6 months (n = 21 intervention group) or similar egg free baked goods (n = 22 control group) while maintaining an otherwise egg free diet...
2017: World Allergy Organization Journal
https://www.readbyqxmd.com/read/28649089/prognostic-nutritional-index-and-the-risk-of-mortality-in-patients-with-acute-heart-failure
#17
Yu-Lun Cheng, Shih-Hsien Sung, Hao-Min Cheng, Pai-Feng Hsu, Chao-Yu Guo, Wen-Chung Yu, Chen-Huan Chen
BACKGROUND: Nutritional status has been related to clinical outcomes in patients with heart failure. We assessed the association between nutritional status, indexed by prognostic nutritional index (PNI), and survival in patients hospitalized for acute heart failure. METHODS AND RESULTS: A total of 1673 patients (age 76±13 years, 68% men) hospitalized for acute heart failure in a tertiary medical center were analyzed. PNI was calculated as 10×serum albumin (g/dL)+0...
June 25, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28649086/early-life-risk-factors-for-incident-atrial-fibrillation-in-the-helsinki-birth-cohort-study
#18
Linda S B Johnson, Minna Salonen, Eero Kajantie, David Conen, Jeff S Healey, Clive Osmond, Johan G Eriksson
BACKGROUND: Early life risk factors are associated with cardiometabolic disease, but have not been fully studied in atrial fibrillation (AF). There are discordant results from existing studies of birth weight and AF, and the impact of maternal body size, gestational age, placental size, and birth length is unknown. METHODS AND RESULTS: The Helsinki Birth Cohort Study includes 13 345 people born as singletons in Helsinki in the years 1934-1944. Follow-up was through national registries, and ended on December 31, 2013, with 907 incident cases...
June 25, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28649053/left-atrial-appendage-occlusion-with-the-amplatzer-amulet-device-periprocedural-and-early-clinical-echocardiographic-data-from-a-global-prospective-observational-study
#19
Ulf Landmesser, Boris Schmidt, Jens Erik Nielsen-Kudsk, Simon Cheung Chi Lam, Jai-Wun Park, Giuseppe Tarantini, Ignacio Cruz-Gonzalez, Volker Geist, Paolo Della Bella, Antonio Colombo, Tobias Zeus, Heyder Omran, Christopher Piorkowski, Juha Lund, Claudio Tondo, David Hildick-Smith
AIMS: The global, prospective AMPLATZER Amulet observational study documents real-world periprocedural, transoesophageal echocardiographic (TEE) and clinical outcomes from left atrial appendage occlusion (LAAO) using the AMPLATZER Amulet device. The aim of this report is to describe the periprocedural and early clinical/TEE results from this study. METHODS AND RESULTS: This multicentre prospective real-world registry included 1,088 patients (75±8.5 years, 64.5% male, CHA2DS2-VASc: 4...
June 25, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28649032/a-standard-mastectomy-should-not-be-the-only-recommended-breast-surgical-treatment-for-non-metastatic-inflammatory-breast-cancer-a-large-population-based-study-in-the-surveillance-epidemiology-and-end-results-database-18
#20
Hongliang Chen, Kejin Wu, Maoli Wang, Fuwen Wang, Mingdi Zhang, Peng Zhang
BACKGROUND: Standard mastectomy has long been the recommended breast surgical treatment for non-metastatic inflammatory breast cancer (IBC). The objective of this population-based study was to evaluate the significance of various breast surgical treatments for this highly aggressive subtype. METHODS: The Surveillance, Epidemiology, and End Results program registry was searched to identify women with non-metastatic IBC receiving standard treatment including breast surgery, radiation therapy and chemotherapy diagnosed between 1998 and 2013...
June 22, 2017: Breast: Official Journal of the European Society of Mastology
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