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Junyu Zhao, Chunmei Xu, Jinming Yao, Changzhen Yu, Lin Liao, Jianjun Dong
BACKGROUND/AIMS: Experimental studies have reported the antineoplastic effects of statins in thyroid carcinoma; however, observational studies suggested that statins might increase the risk of thyroid carcinoma. Therefore, this study evaluated the antineoplastic effects of statins in both in vitro studies and animal models, as well as the epidemiological evidence. METHODS: Databases-PubMed, Cochrane Library, SinoMed, CNKI, Wanfang, and clinical trial registries- were searched...
June 19, 2018: Cellular Physiology and Biochemistry
A M Api, D Belsito, D Botelho, M Bruze, G A Burton, J Buschmann, M L Dagli, M Date, W Dekant, C Deodhar, M Francis, A D Fryer, L Jones, K Joshi, S La Cava, A Lapczynski, D C Liebler, D O'Brien, A Patel, T M Penning, G Ritacco, J Romine, N Sadekar, D Salvito, T W Schultz, I G Sipes, G Sullivan, Y Thakkar, Y Tokura, S Tsang
No abstract text is available yet for this article.
June 18, 2018: Food and Chemical Toxicology
Sunao Kojima, Kensaku Nishihira, Misa Takegami, Yoko M Nakao, Satoshi Honda, Jun Takahashi, Morimasa Takayama, Hiroaki Shimokawa, Tetsuya Sumiyoshi, Hisao Ogawa, Kazuo Kimura, Satoshi Yasuda
Background: Cardiovascular diseases, including acute myocardial infarction (AMI), are leading causes of death among the Japanese, who have the longest life expectancy in the world. Over the past 50 years in Japan, the percentage of elderly individuals has increased 4-fold, from 5.7% in 1960 to 23.1% in 2010. To explore medical practices and emergency care for AMI in this aging society, the Japan Acute Myocardial Infarction Registry (JAMIR) was established as a nationwide real-world database...
September 2018: IJC Heart & Vasculature
Laura Martinez-Prat, Michael J Nissen, Céline Lamacchia, Chelsea Bentow, Laura Cesana, Pascale Roux-Lombard, Cem Gabay, Michael Mahler
Introduction: The diagnosis of rheumatoid arthritis (RA) is based on a combined approach that includes serological markers such as rheumatoid factor (RF) and anti-citrullinated peptide/protein antibodies (ACPA). The goal of this study was to evaluate the clinical performance of several RF and ACPA immunoassays for the diagnosis of RA, as well as the diagnostic value of a combinatory approach with these markers. Methods: The study cohort included 1,655 patients from the Swiss Clinical Quality Management registry with sera from 968 patients with RA and 687 disease controls, including patients with axial spondyloarthritis ( n  = 450) and psoriatic arthritis ( n  = 237)...
2018: Frontiers in Immunology
Rosa M Vivanco-Hidalgo, Sònia Abilleira, Mercè Salvat-Plana, Aida Ribera, Guillem Gallofré, Miquel Gallofré
Stroke, and mainly ischemic stroke, is the second cause of death and disability. To confront the huge burden of this disease, innovative stroke systems of care are mandatory. This requires the development of national stroke plans to offer the best treatment to all patients eligible for reperfusion therapies. Key elements for success include a high level of organization, close cooperation with emergency medical services for prehospital assessment, an understanding of stroke singularity, the development of preassessment tools, a high level of commitment of all stroke teams at Stroke Centres, the availability of a disease-specific registry, and local government involvement to establish stroke care as a priority...
2018: Frontiers in Neurology
Huiqiao Tian, Mark W Parsons, Christopher R Levi, Xin Cheng, Richard I Aviv, Neil J Spratt, Timothy J Kleinig, Billy O'Brien, Kenneth S Butcher, Longting Lin, Jingfen Zhang, Qiang Dong, Chushuang Chen, Andrew Bivard
Background and Purpose: The benefit of thrombolysis in ischemic stroke patients without a visible vessel occlusion still requires investigation. This study tested the hypothesis that non-lacunar stroke patients with no visible vessel occlusion on baseline imaging would have a favorable outcome regardless of treatment with alteplase. Methods: We utilized a prospectively collected registry of ischemic stroke patients [the International Stroke Perfusion Imaging Registry (INSPIRE)] who had baseline computed tomographic perfusion and computed tomographic angiography...
2018: Frontiers in Neurology
Sabine Flommersfeld, Carsten Mand, Christian A Kühne, Gregor Bein, Steffen Ruchholtz, Ulrich J Sachs
Background: Immediate supply of red blood cell (RBC) concentrates is crucial in the initial treatment of exsanguinating patients in the emergency room. General shortage of RhD- RBCs has led to protocols in which patients with unknown blood groups are initially transfused with group O, RhD+ RBCs. Limited data are available regarding the safety of such an approach. Methods: Transfusion protocols for all multiple injured patients from the regional polytrauma database were retrospectively analyzed over a period of 5 years...
May 2018: Transfusion Medicine and Hemotherapy
Isabela Maia Diniz, Augusto Afonso Guerra, Livia Lovato Pires de Lemos, Kathiaja M Souza, Brian Godman, Marion Bennie, Björn Wettermark, Francisco de Assis Acurcio, Juliana Alvares, Eli Iola Gurgel Andrade, Mariangela Leal Cherchiglia, Vânia Eloisa de Araújo
BACKGROUND: Multiple Sclerosis (MS) is a disease that appreciably impacts on the quality of life of patients and is associated with high expenditure. MS is a chronic multifactorial disease, characterized by inflammation, demyelination and axonal loss. The Brazilian public health system provides pharmacological treatment as well as hospital and outpatient care for patients with relapsing-remitting and secondary progressive multiple sclerosis. However, we are not aware of any previous publications assessing total direct medical costs in patients with a long follow-up within the Brazilian healthcare system...
2018: PloS One
Kjell Vegard Weyde, Norun Hjertager Krog, Bente Oftedal, Per Magnus, Richard White, Stephen Stansfeld, Simon Øverland, Gunn Marit Aasvang
BACKGROUND: Being overweight constitutes a health risk, and the proportion of overweight and obese children is increasing. It has been argued that road traffic noise could be linked to adiposity through its influence on sleep and stress. Few studies, to our knowledge, have investigated whether noise and adiposity are associated. Most of them were on adults, and we are not aware of any longitudinal study using repeated measures. OBJECTIVES: The present longitudinal study investigated whether road traffic noise exposures in pregnancy (N=6,963; obs=22,975) or childhood (N=6,403; obs=14,585) were associated with body mass index (BMI) trajectories in children...
June 20, 2018: Epidemiology
Roger Diegel, Brad Black, Jean C Pfau, Tracy McNew, Curtis Noonan, Raja Flores
An increased risk for Systemic Autoimmune Diseases (SAID) has been reported in Libby, Montana, where extensive exposures to fibrous amphiboles occurred due to mining and use of asbestos-laden vermiculite. In addition, positive antinuclear autoantibody tests are associated with exposure to Libby Asbestiform Amphiboles (LAA) in both humans and mice. Among 6603 subjects who underwent health screening at the Center for Asbestos Related Diseases (CARD, Libby MT), 13.8% were diagnosed with an autoimmune disease, with prevalence values for the most common SAID being significantly higher than expected in the United States...
June 21, 2018: Journal of Toxicology and Environmental Health. Part A
Drew A Lansdown, Kyle Kunze, Gift Ukwuani, Brian R Waterman, Shane J Nho
BACKGROUND: The specific influence of preoperative and postoperative radiographic measurements on patient-reported outcome measures after hip arthroscopy for femoroacetabular impingement (FAI) remains unclear. PURPOSE: To investigate the relationship between radiographic measurements and 2-year outcomes after hip arthroscopy for the treatment of FAI. STUDY DESIGN: Case series; Level of evidence, 4. METHODS: A clinical registry of patients undergoing primary hip arthroscopy for FAI between January 1, 2012, and December 31, 2014, was queried...
June 1, 2018: American Journal of Sports Medicine
Guy H T Worley, Nicola S Fearnhead, Steven R Brown, Austin G Acheson, Matthew J Lee, Omar D Faiz
INTRODUCTION: The second ACPGBI Ileoanal Pouch Registry (IPR) report was released in July 2017 following a first report in 2012. This article provides a summary of data derived from the most recent IPR report (1). METHOD: The IPR is an electronic database of voluntarily submitted data including patient demographics, disease, intra and post-operative factors submitted by consultant surgeons or delegates. Data up to 31st March 2017 have been analysed for this report...
June 21, 2018: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
Rosalia Maria Nunes Henriques Huaira, Rogerio Baumgratz de Paula, Marcus Gomes Bastos, Fernando Antonio Basile Colugnati, Natália Maria da Silva Fernandes
INTRODUCTION: Chronic diseases account for the majority of deaths in Brazil. These include hypertension (SAH) and diabetes mellitus (DM), which are the main causes of chronic kidney disease (CKD). OBJECTIVE: This study aimed to validate the data of an electronic health record and to point out characteristics of the profile of these users in relation to clinical quality indicators for a pre-dialytic CKD. METHODS: Retrospective cohort, August/2010 to December/2014...
June 7, 2018: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
Huangling Lu, Robbert J de Winter, Karel T Koch
Coronary stent designs have been through extensive developments in the past few decades. Since the first introduction of the self-apposing STENTYS stent, several theoretical advantages of its nitinol platform have been clinically evaluated. This paper reviews the current status, ongoing work and future directions of this device. Areas covered: The OPEN (STENTYS Coronary Bifurcation Stent System fOr the PErcutaNeous treatment of de novo lesions in native bifurcated coronary arteries) trials revealed high technical success rates of the STENTYS performance in bifurcation lesions...
June 21, 2018: Expert Review of Medical Devices
Kelly L Klump, Natasha Fowler, Laura Mayhall, Cheryl L Sisk, K M Culbert, S Alexandra Burt
Puberty is a critical period for changes in genetic effects for binge eating in girls. Previous twin studies show increases in genetic influences on binge eating from prepuberty (∼0%) to midpuberty and beyond (∼50%). However, little is known about the factors that drive these shifts in genetic effects. A small pilot study showed that pubertal activation of estrogen may contribute to increases in genetic influences, possibly via hormonally induced changes in gene expression. However, large-scale studies investigating hormone effects on genetic risk are lacking...
June 21, 2018: Journal of Abnormal Psychology
Xiayi Lv, Jinlin Cao, Xiaona Dai, Aizemaiti Rusidanmu
BACKGROUND: Lung cancer in the right middle lobe has a poorer prognosis than tumors located in other lobes. The optimal surgical procedure for early-stage non-small cell lung cancer (NSCLC) in the right middle lobe has not yet been elucidated. The aim of this study was to compare survival rates after lobectomy and sublobar resection for early-stage right middle lobe NSCLC. METHODS: Patients who underwent lobectomy or sublobar resection for stage IA right middle lobe NSCLC tumors ≤ 2 cm between 2004 and 2014 were identified from the Surveillance, Epidemiology and End Results database of 18 registries...
June 21, 2018: Thoracic Cancer
Yun Gi Kim, Jaemin Shim, Dong-Hyeok Kim, Jong-Il Choi, Sang-Weon Park, Hui-Nam Pak, Young-Hoon Kim
INTRODUCTION: Radiofrequency catheter ablation (RFCA) in atrial fibrillation (AF) patients can cause various complications and atrioesophageal (AE) fistula is one of the most catastrophic complications of RFCA. METHODS AND RESULTS: RFCA registries from 3 cardiovascular centers in Republic of Korea consisted of 5,721 patients undergoing 6,724 procedures. Before undergoing RFCA, patients underwent either computed tomography or magnetic resonance imaging. We evaluated clinical, anatomical, and procedural characteristics of patients who developed AE fistula after RFCA...
June 21, 2018: Journal of Cardiovascular Electrophysiology
Tim Bullman, Aaron Schneiderman, Jaimie L Gradus
OBJECTIVE: Research has demonstrated that posttraumatic stress disorder (PTSD) among Vietnam veterans is associated with increased risk of suicide. It is also widely reported that suicide is related to depression. This study examined the effect of PTSD and depression on risk of suicide among a cohort of Vietnam veterans. METHOD: All study subjects were selected from the Department of Veterans Affairs Agent Orange Registry. Suicide risk associated with PTSD was first assessed by comparing the number of suicides among a cohort of 2,874 veterans with PTSD to that of 8,537 veterans not diagnosed with PTSD...
June 21, 2018: Suicide & Life-threatening Behavior
Filippa Nyboe Norsker, Catherine Rechnitzer, Luise Cederkvist, Laufey Tryggvadottir, Laura-Maria Madanat-Harjuoja, Ingrid Øra, Halldora K Thorarinsdottir, Kim Vettenranta, Andrea Bautz, Henrik Schrøder, Henrik Hasle, Jeanette Falck Winther
Because of the rarity of neuroblastoma and poor survival until the 1990s, information on late effects in neuroblastoma survivors is sparse. We comprehensively reviewed the long-term risk for somatic disease in neuroblastoma survivors. We identified 721 5-year survivors of neuroblastoma in Nordic population-based cancer registries and identified late effects in national hospital registries covering the period 1977-2012. Detailed treatment information was available for 46% of the survivors. The disease-specific rates of hospitalization of survivors and of 152,231 randomly selected population comparisons were used to calculate standardized hospitalization rate ratios (SHRRs) and absolute excess risks (AERs)...
June 21, 2018: International Journal of Cancer. Journal International du Cancer
Ho Cheol Kim, Chi Young Jung, Deog Gon Cho, Jae Hyun Jeon, Jeong Eun Lee, Jin Seok Ahn, Seung Joon Kim, Yeongdae Kim, Young Chul Kim, Jung Eun Kim, Boram Lee, Young Joo Won, Chang Min Choi
BACKGROUND: Lung cancer is a leading cause of morbidity and mortality worldwide, and the incidence continues to rise. Although many prognostic factors have been identified, the clinical characteristics and outcomes in Korean lung cancer patients are not well defined. METHODS: Of the 23,254 new lung cancer cases registered at the Korea Central Cancer Registry in 2013, total 489 patients from 19 hospitals were abstracted by the Korean Central Cancer Registry. The clinical data retrospectively analyzed, patients were followed up until December 2015...
June 19, 2018: Tuberculosis and Respiratory Diseases
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