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https://www.readbyqxmd.com/read/29765367/detection-of-bacteriophage-particles-containing-antibiotic-resistance-genes-in-the-sputum-of-cystic-fibrosis-patients
#1
Maryury Brown-Jaque, Lirain Rodriguez Oyarzun, Thais Cornejo-Sánchez, Maria T Martín-Gómez, Silvia Gartner, Javier de Gracia, Sandra Rovira, Antonio Alvarez, Joan Jofre, Juan J González-López, Maite Muniesa
Cystic fibrosis (CF) is a chronic disease in which the bacterial colonization of the lung is linked to an excessive inflammatory response that leads to respiratory failure. The microbiology of CF is complex. Staphylococcus aureus is the first bacterium to colonize the lungs in 30% of pediatric CF patients, and 80% of adult patients develop a chronic Pseudomonas aeruginosa infection, but other microorganisms can also be found. The use of antibiotics is essential to treat the disease, but antibiotic performance is compromised by resistance mechanisms...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29756725/-tuberculosis-by-multiresistant-mycobacterium-africanum-pediatric-clinical-case
#2
Júlia Morata Alba, Paloma Beltrán Catalá, Nelson Orta Sibú
Tuberculosis, considered since 2003 by the World Health Organization a global health emergency, causes annual mortality of approximately 2 million people, mainly in developing countries. In the Spanish pediatric population, the incidence is 5 cases/100 000 children between 5 and 14 years and 13 cases/100 000 children between 0 and 4 years. The infection is transmitted through the respiratory tract by baciliferous patients. Children eliminate few bacilli in respiratory secretions and do not usually transmit the infection...
June 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29748922/defining-the-relationship-between-phenotypic-and-genotypic-resistance-profiles-of-multidrug-resistant-enterobacterial-clinical-isolates
#3
Lamis Galal, Neveen A Abdel Aziz, Walaa M Hassan
Fluoroquinolones and aminoglycosides offer effective therapy for extended-spectrum beta-lactamase (ESBL)-producing enterobacterial infections, but their usefulness is threatened by increasing resistant strains. OBJECTIVE: This study was conducted to demonstrate the phenotypic outcomes of the coexistence of genetic determinants mediating resistance to extended-spectrum cephalosporins and quinolones in enterobacterial isolates collected from patients with health-care-associated infections in Egypt...
May 11, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29743795/prevalence-and-impact-of-bacterial-infections-in-children-with-liver-disease-a-prospective-study
#4
Rishi Bolia, Anshu Srivastava, Rungmei Marak, Surender K Yachha, Ujjal Poddar
Background and aims: Risk of infections is increased in patients with Acute Liver Failure (ALF) and Decompensated Chronic Liver Disease (DCLD). We evaluated the frequency, site, type and risk-factors for bacterial infections in children with ALF and DCLD and its effect on outcome. Methods: ALF or DCLD children were enrolled prospectively. Clinical and laboratory details were recorded. Cultures (blood, urine and ascites) and chest X-ray were done at admission followed by weekly surveillance cultures...
March 2018: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29742211/antibiotic-therapy-in-ventilator-associated-tracheobronchitis-a-literature-review
#5
Abel Eduardo Alves, José Manuel Pereira
The concept of ventilator-associated tracheobronchitis is controversial; its definition is not unanimously accepted and often overlaps with ventilator-associated pneumonia. Ventilator-associated tracheobronchitis has an incidence similar to that of ventilator-associated pneumonia, with a high prevalence of isolated multiresistant agents, resulting in an increase in the time of mechanical ventilation and hospitalization but without an impact on mortality. The performance of quantitative cultures may allow better diagnostic definition of tracheobronchitis associated with mechanical ventilation, possibly avoiding the overdiagnosis of this condition...
March 2018: Revista Brasileira de Terapia Intensiva
https://www.readbyqxmd.com/read/29740989/activity-of-fosfomycin-against-nosocomial-multiresistant-bacterial-pathogens-from-croatia-a-multicentric-study
#6
Luka Bielen, Robert Likić, Viktorija Erdeljić, Ivana Mareković, Nataša Firis, Marijana Grgić-Medić, Ana Godan, Ivan Tomić, Blaženka Hunjak, Alemka Markotić, Danijela Bejuk, Vladimira Tičić, Silvana Balzar, Branka Bedenić
AIM: To determine in vitro susceptibility of multiresistant bacterial isolates to fosfomycin. METHODS: In this prospective in vitro study (local non-random sample, level of evidence 3), 288 consecutively collected multiresistant bacterial isolates from seven medical centers in Croatia were tested from February 2014 until October 2016 for susceptibility to fosfomycin and other antibiotics according to Clinical and Laboratory Standards Institute methodology. Susceptibility to fosfomycin was determined by agar dilution method, while disc diffusion was performed for in vitro testing of other antibiotics...
April 30, 2018: Croatian Medical Journal
https://www.readbyqxmd.com/read/29734648/bioactivity-guided-isolation-of-antimicrobial-and-antioxidant-metabolites-from-the-mushroom-tapinella-atrotomentosa
#7
Zoltán Béni, Miklós Dékány, Bernadett Kovács, Boglárka Csupor-Löffler, Zoltán Péter Zomborszki, Erika Kerekes, András Szekeres, Edit Urbán, Judit Hohmann, Attila Ványolós
Bioassay-guided fractionation of the chloroform extract of Tapinella atrotomentosa led to the isolation of four secondary metabolites 1 ⁻ 4 . Two of the compounds are lactones—osmundalactone ( 1 ) and 5-hydroxy-hex-2-en-4-olide ( 2 )—while 3 and 4 were identified as terphenyl quinones, spiromentins C and B, respectively. The structures of the compounds were established on the basis of NMR and MS spectroscopic analysis. The isolated fungal metabolites were evaluated for their antibacterial activities against several Gram-positive and negative bacteria...
May 4, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29727894/-comparison-of-the-antibacterial-efficacy-of-polyhexanide-cold-atmospheric-argon-plasma-and-saline-in-the-treatment-of-canine-bite-wounds
#8
Selina Winter, Mirja Christine Nolff, Sven Reese, Andrea Meyer-Lindenberg
ZIEL: der Studie war, die Keimbelastung sowie die klinische Effizienz von Polyhexanid, Argon-Kaltplasma und Kochsalzlösung zur Reduktion der Bioburden bei Hundebissverletzungen zu überprüfen. MATERIAL UND METHODEN: In die Studie eingeschlossen wurden Hunde mit Bissverletzungen, die durch ein chirurgisches Debridement mit anschließender Wundbehandlung durch Lavage mit Polyhexanid-Biguanid (A), Therapie mit kaltem Argonplasma (B) oder Lavage mit physiologischer Kochsalzlösung (C) versorgt wurden...
April 2018: Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere
https://www.readbyqxmd.com/read/29716725/staphylococcus-aureus-colonization-in-an-institutionalized-elderly-population-long-term-care-facilities-in-the-bay-of-cadiz-area-spain-prevalence-and-associated-risk-factors
#9
María Pérez-Eslava, Nuria López-Ruíz, Elvira María Flores-Cebada, Manuel Rodríguez-Iglesias, Fátima Galán-Sánchez
BACKGROUND AND OBJECTIVE: Staphylococcus aureus is a health problem behind a great variety of infections. The objective of the study was to establish the prevalence and risk factors of S. aureus carriers in community nursing homes in Cadiz. PATIENTS AND METHOD: A cross study from September 2016 to May 2017. POPULATION: All residents institutionalized in the largest long-term care facilities centers in Cadiz. The main variable was being a S...
April 28, 2018: Medicina Clínica
https://www.readbyqxmd.com/read/29712650/activity-of-combinations-of-antistaphylococcal-antibiotics-with-fusidic-acid-against-staphylococcal-biofilms-in-in-vitro-static-and-dynamic-models
#10
Wafi Siala, Hector Rodriguez-Villalobos, Prabhavathi Fernandes, Paul M Tulkens, Françoise Van Bambeke
Staphylococcal biofilms are a major cause of therapeutic failure, especially when caused by multiresistant strains. Oral fusidic acid is currently being re-developed in the US for skin and skin structure and orthopedic infections, in which biofilms play a major role. The aim of this study was to examine the activity of fusidic acid alone or combined with other anti-staphylococcal drugs against biofilms made by a reference strain and five clinical isolates of Staphylococcus aureus or Staphylococcus epidermidis in in vitro static or dynamic models (microtiter plates and CDC reactor) exposed to clinically-relevant concentrations...
April 30, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29685376/single-tube-classical-pcr-for-candida-auris-and-candida-haemulonii-identification
#11
Laura Theill, Catiana Dudiuk, Soraya Morales-Lopez, Indira Berrio, José Yesid Rodríguez, Adriana Marin, Soledad Gamarra, Guillermo Garcia-Effron
BACKGROUND: Candida auris and Candida haemulonii are emerging and multiresistant pathogens. C. auris has produced hospital outbreaks and is misidentified by phenotypic-based methods. The only reliable identification methods are DNA sequencing and MALDI-TOF. AIMS: To develop a classical-PCR method capable of rapidly and accurately identify C. auris and C. haemulonii. METHODS: A multiplex PCR was carried out in one tube that included an internal control and oligonucleotides that specifically hybridize to the ITS2 region of C...
April 20, 2018: Revista Iberoamericana de Micología
https://www.readbyqxmd.com/read/29684931/-multiresistant-bacteria-antibiotic-prescription-and-antibiotics-of-last-resort
#12
Winfried V Kern
Ascertaining critical indications for antibiotics and rational prescribing can delay and minimize the spread of antibiotic resistance. Room for improvement lies in particular in a stricter indication, in shortening antibiotic treatment and in initiating more targeted therapies with narrow-spectrum drugs. Not all infections due to multidrug-resistant organisms require treatment with reserve drugs. Detailed susceptibility testing together with enhanced knowledge of pharmacokinetics and -dynamics are needed for adequate treatment decisions...
May 2018: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29662260/characterization-of-multidrug-resistant-acinetobacter-ssp-strains-isolated-from-medical-intensive-care-units-in-cali-colombia
#13
Rómel Fabian Gómez, Andres Castillo, Mónica Chávez-Vivas
Introduction: The extensive use of antibiotics has led to the emergence of multi-resistant strains in some species of the genus Acinetobacter . Objective: To investigate the molecular characteristics of multidrug-resistant of Acinetobacter ssp. strains isolated from 52 patients collected between March 2009 and July 2010 in medical intensive care units in Cali - Colombia. Methods: The susceptibility to various classes of antibiotics was determined by disc diffusion method, and the determination of the genomic species was carried out using amplified ribosomal DNA restriction analysis (ARDRA) and by sequencing of the 16s rDNA gene...
December 30, 2017: Colombia Médica: CM
https://www.readbyqxmd.com/read/29658220/-multiresistant-bacteria-practical-aspects-for-doctors-working-in-ambulatory-practice
#14
Sarah Masson-Roy, Stephan Harbarth
Although preventive measures against the transmission of multidrug-resistant organisms (MDROs) are well established and protocolized in hospital settings, their implementation in private ambulatory practice are rarely addressed. Despite what is sometimes communicated, the risk of transmission of this type of bacteria outside of a hospital environment is real. Standard precautions are the key to minimizing this risk. In a number of situations in the ambulatory setting, MDRO screening (nasal or rectal) is needed and recommended...
April 11, 2018: Revue Médicale Suisse
https://www.readbyqxmd.com/read/29649808/treatment-of-complicated-urinary-tract-infections-in-individuals-with-chronic-neurogenic-lower-urinary-tract-dysfunction-are-antibiotics-mandatory
#15
Jürgen Pannek, Susanne Pannek-Rademacher, Jens Wöllner
INTRODUCTION: Urinary tract infections (UTI) in patients with neurogenic lower urinary tract dysfunction (NLUTD) are defined as complicated UTI requiring antibiotic treatment. As the emergence of multiresistant strains is a serious problem, we assessed the feasibility of nonantibiotic treatment of UTI in patients with NLUTD. MATERIALS AND METHODS: In a prospective study evaluating the usefulness of UTI prophylaxis, participants could opt for either antibiotic or nonantibiotic treatment of breakthrough UTI...
April 12, 2018: Urologia Internationalis
https://www.readbyqxmd.com/read/29649587/a-novel-tool-against-multiresistant-bacterial-pathogens-lipopeptide-modification-of-the-natural-antimicrobial-peptide-ranalexin-for-enhanced-antimicrobial-activity-and-improved-pharmacokinetics
#16
Cornelius Domhan, Philipp Uhl, Anna Meinhardt, Stefan Zimmermann, Christian Kleist, Thomas Lindner, Karin Leotta, Walter Mier, Michael Wink
As evolutionary optimized defense compounds, antimicrobial peptides (AMPs) represent a powerful tool against bacterial infections. Ranalexin, an AMP found in the skin of the American bullfrog (Rana catesbeiana), is primarily active against Gram-positive bacteria with a minimum inhibitory concentration (MIC) of 8 - 16 mg/L but shows weaker activity against Gram-negative bacteria (> 64 mg/L). By substitution of 6 N-terminal amino acids by decanoic (C10:0) to myristic (C14:0) acid, we were able to develop lipopeptide derivatives with enhanced antimicrobial activity...
April 9, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29649297/diversity-of-cultivable-fungal-endophytes-in-paullinia-cupana-mart-ducke-and-bioactivity-of-their-secondary-metabolites
#17
Fábio de Azevedo Silva, Rhavena Graziela Liotti, Ana Paula de Araújo Boleti, Érica de Melo Reis, Marilene Borges Silva Passos, Edson Lucas Dos Santos, Olivia Moreira Sampaio, Ana Helena Januário, Carmen Lucia Bassi Branco, Gilvan Ferreira da Silva, Elisabeth Aparecida Furtado de Mendonça, Marcos Antônio Soares
Paullinia cupana is associated with a diverse community of pathogenic and endophytic microorganisms. We isolated and identified endophytic fungal communities from the roots and seeds of P. cupana genotypes susceptible and tolerant to anthracnose that grow in two sites of the Brazilian Amazonia forest. We assessed the antibacterial, antitumor and genotoxic activity in vitro of compounds isolated from the strains Trichoderma asperellum (1BDA) and Diaporthe phaseolorum (8S). In concert, we identified eight fungal species not previously reported as endophytes; some fungal species capable of inhibiting pathogen growth; and the production of antibiotics and compounds with bacteriostatic activity against Pseudomonas aeruginosa in both susceptible and multiresistant host strains...
2018: PloS One
https://www.readbyqxmd.com/read/29642437/photodynamic-effect-of-methylene-blue-and-low-level-laser-radiation-in-head-and-neck-squamous-cell-carcinoma-cell-lines
#18
Barbara Kofler, Angela Romani, Christian Pritz, Teresa Bernadette Steinbichler, Volker Hans Schartinger, Herbert Riechelmann, Jozsef Dudas
Photodynamic therapy (PDT) is suggested to have an impact on the treatment of early stage head and neck cancers (HNSCC). We investigated the effect of PDT with methylene blue (MB) and a diode laser (660 nm) as the laser source on HNSCC cell lines as an in vitro model of surface oral squamous cell carcinoma. Cell-cultures were exposed to 160 µM MB for 4 min and to laser light for 8 min. Viability was proven via cell viability assay and clonogenic survival via clone counting assay. The combination of MB and diode laser evidenced high efficient loss of cell viability by 5% of the control, while treatment with the same concentration of MB for 4 min alone showed a viability of 46% of the control...
April 7, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29623072/biodiversity-and-microbial-resistance-of-lactobacilli-isolated-from-the-traditional-greek-cheese-kopanisti
#19
Georgios Rozos, Chrysa Voidarou, Elisavet Stavropoulou, Ioannis Skoufos, Athina Tzora, Athanasios Alexopoulos, Eugenia Bezirtzoglou
Kopanisti is a Greek artisan cheese produced from raw milk in the island of Mykonos, Greece. The milk is left to rest for 12-24 h and then the rennet is added. After its formation the curd is left to drain for 2-3 days and is ready either for consumption (as tyrovolia fresh cheese), or with the addition of extra salt, the curd is left to ripen through further fermentation and surface development of Penicillium fungi, aprocess leading to the production of the traditional Greek cheese Kopanisti. From 120 samples of kopanisti, 574 Lactobacillus strains were isolated, distributed in 17 species (16 of them isolated from tyrovolia as well)...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29620487/presence-of-classical-enterotoxin-genes-agr-typing-antimicrobial-resistance-and-genetic-diversity-of-staphylococcus-aureus-from-milk-of-cows-with-mastitis-in-southern-brazil
#20
Isabela S Kroning, Mariana A Iglesias, Karla S Mendonça, Graciela V Lopes, Wladimir P Silva
Staphylococcus aureus is a common causative agent of bovine mastitis in dairy cows and commonly associated with foodborne disease outbreaks. The aim of this study was to evaluate the presence of enterotoxin genes, agr typing, antimicrobial resistance, and genetic diversity of S. aureus isolated from milk of cows with mastitis in dairy farms from southern Brazil. Results showed that 7 (22.6%) of 31 S. aureus isolates were positive for enterotoxin genes. Specifically, the genes encoding for enterotoxins A ( n = 4), C ( n = 2), and B ( n = 1) were detected...
April 5, 2018: Journal of Food Protection
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