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https://www.readbyqxmd.com/read/28522904/importance-of-antimicrobial-susceptibility-testing-for-the-management-of-eradication-in-helicobacter-pylori-infection
#1
REVIEW
Nazlı Arslan, Özlem Yılmaz, Ebru Demiray-Gürbüz
The management of Helicobacter pylori (H. pylori) infection treatment differs from the common treatment protocol for other infectious diseases. Because culture- or molecular-guided approaches face several practical issues, such as the invasive procedures required to obtain gastric biopsy specimens and the lack of availability of routine laboratory testing in some places, H. pylori treatment includes the administration of two or three empirically selected antibiotics combined with a proton pump inhibitor rather than evidence-based eradication treatment...
April 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28515630/an-exception-to-the-rule-no-association-between-antibiotic-resistance-and-decreased-disinfectant-microbicidal-efficacy-orthophthalaldehyde-opa-and-pseudomonas-aeruginosa-isolated-from-icu-and-paraplegic-patients
#2
REVIEW
R Herruzo, M J Vizcaíno, I Herruzo
BACKGROUND: Antibiotic resistance and decreased susceptibility to disinfectants are not usually associated in microorganisms, but we have found an exception to this rule: P. aeruginosa versus orthophthalaldehyde (OPA). METHODS: Bactericidal effect of OPA was measured at 10 minutes on endodoncy files contaminated with an ATCC strain (control) or 206 strains of P. aeruginosa recently isolated from 206 ICU and paraplegic patients in a tertiary university hospital, in two consecutive years...
March 2017: Journal of Preventive Medicine and Hygiene
https://www.readbyqxmd.com/read/28508718/frondoside-a-induces-aif-associated-caspase-independent-apoptosis-in-burkitt-lymphoma-cells
#3
Sergey A Dyshlovoy, Stefanie Rast, Jessica Hauschild, Katharina Otte, Winfried H Alsdorf, Ramin Madanchi, Vladimir I Kalinin, Alexandra S Silchenko, Sergey A Avilov, Judith Dierlamm, Friedemann Honecker, Valentin A Stonik, Carsten Bokemeyer, Gunhild von Amsberg
For patients with refractory or relapsed Burkitt lymphoma (BL), no standard therapy is available for second-line treatment to date. Nonfunctional caspases-dependent apoptosis pathways, inactivating p53 mutations and pro-survival autophagy prevent activity of conventional chemotherapy. Thus, new drugs bypassing these mechanisms of resistance are required. Here, we investigated the efficacy of the marine natural compound frondoside A (FrA) in eight BL cell lines. FrA revealed cytotoxic effects in all cell lines tested including the multiresistant CA46 cells...
May 16, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28493114/-management-of-multiresistant-bacteria-in-urology
#4
REVIEW
W Vahlensieck, R Rudolph, H-J Knopf, U Dahl, W Fabry
Contamination and infection with extensive drug resistant (XDR) bacteria are increasing in urology with the exception of methicillin resistant Staphylococcus aureus (MRSA) (stabilization). They often lead to logistic and therapeutical problems. Only 30-50% of XDR cases are of exogenous origin. To slow this trend, screening, hygiene programs, isolation, decontamination, targeted therapy of symptomatic infections, education programs, and success controls should be applied. Furthermore, all regulatory and legal instructions should be followed...
May 10, 2017: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/28485709/occurrence-and-characterization-of-class-1-integrons-in-escherichia-coli-from-healthy-individuals-and-those-with-urinary-infection
#5
Clarisse Oliveira-Pinto, Cristiane Diamantino, Patrícia L Oliveira, Mariana P Reis, Patrícia S Costa, Magna C Paiva, Regina M D Nardi, Paula P Magalhães, Edmar Chartone-Souza, Andréa M A Nascimento
PURPOSE: Class 1 integrons are among the main vehicles that facilitate the spread of antibiotic-resistance genes, with serious public health consequences. The aim of this cross-sectional study was to investigate the presence of class 1 integrons and to characterize their variable regions, as well as the antimicrobial resistance profiles and phylogenetic groups of a collection of Escherichia coli isolates recovered from healthy subjects (n=42) and those with urinary infection (n=40). METHODOLOGY: The methods used included PCR, sequencing and antimicrobial susceptibility testing...
May 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28472416/impact-on-morbidity-mortality-and-length-of-stay-of-hospital-acquired-infections-by-resistant-microorganisms
#6
J Ignacio Barrasa-Villar, Carlos Aibar-Remón, Purificación Prieto-Andrés, Rosa Mareca-Doñate, Javier Moliner-Lahoz
Background: Infections by multiresistant organisms (MRO) are a global threat and particularly common in hospitals. This study was performed to assess the impact of hospital acquired infections caused by MRO on morbidity, mortality and length of hospital stay. Methods: Retrospective cohort study. A sample of adults aged ≥18 years with a respiratory, urinary, bloodstream or surgical site infection caused by a multiresistant (cases) or sensitive (controls) microorganism was selected...
May 2, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28470635/-antibiotic-stewardship-and-infection-control-two-pages-of-a-coin
#7
Petra Gastmeier
According to public awareness, high rates of multiresistant organisms in healthcare facilities are mainly associated with two terms: "Hospital" and "Infection control problem". The use of antibiotics in ambulatory and hospital care is probable at least as important or even more important. Antibiotics lead to selection of multiresistant organisms. Microbiome research will lead to a better understanding of this relationship and may provide new measures for preventing the spread of multiresistant organisms. The available data underline the need of a close interaction between antibiotic stewardship and infection control...
April 2017: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
https://www.readbyqxmd.com/read/28457548/molecular-characterization-and-antibiotic-resistance-of-staphylococcus-spp-isolated-from-cheese-processing-plants
#8
Marjory Xavier Rodrigues, Nathália Cristina Cirone Silva, Júlia Hellmeister Trevilin, Melina Mary Bravo Cruzado, Tsai Siu Mui, Fábio Rodrigo Sanches Duarte, Carmen J Contreras Castillo, Solange Guidolin Canniatti-Brazaca, Ernani Porto
The aim of this research paper was to characterize coagulase-positive and coagulase-negative staphylococci from raw milk, Minas cheese, and production lines of Minas cheese processing. One hundred isolates from 3 different cheese producers were characterized using molecular approaches, such as PCR, molecular typing, and DNA sequencing. Staphylococcus aureus (88% of the isolates) was the most abundant followed by Staphylococcus epidermidis, Staphylococcus hyicus, and Staphylococcus warneri. Among the 22 enterotoxin genes tested, the most frequent was seh (62% of the isolates), followed by selx and ser...
April 27, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28455576/-pathogenesis-of-urinary-tract-infections-an-update
#9
REVIEW
G Magistro, J Marcon, S Schubert, C Gratzke, C G Stief
Urinary tract infections are among the most common bacterial infections worldwide. The management has become a public health concern of socioeconomic importance. Every second woman will experience at least one episode in her lifetime. Due to the emergence of multiresistant pathogens and the developmental void, treatment has become more challenging over the years. Deciphering the complex molecular interaction between host and pathogen is necessary to identify potent treatment targets for future approaches. The objective of this review is to present novel aspects on the pathogenesis of urinary tract infections and its relevance for clinical practice...
April 28, 2017: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/28451747/-community-acquired-urinary-tract-infections-association-with-risk-factors-changes-in-causative-organisms-and-resistance-over-time
#10
B Ubrig, M Böhme, A Merklinghaus, F Wagenlehner
BACKGROUND: Published studies on community-acquired urinary tract infections (UTI) often do not link microbiological findings with clinical risk factors and patient data. MATERIALS AND METHODS: We retrospectively correlated clinical findings of all patients with UTI of a urological outpatient clinic with the respective microbiological analysis of their urine samples over 2 periods of time: (A: 2005-2006 and B: 2011-2012). Patients were stratified to the following risk groups: uncomplicated cystitis, diabetes mellitus type 2, nursing home resident, prostatitis/epidydimitis, permanent catheter...
April 27, 2017: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/28444242/virulence-and-antimicrobial-resistance-of-salmonella-spp-and-escherichia-coli-in-the-beef-jerky-production-line
#11
Fernanda Pereira Fernandes, Flávia Liége Schütz Voloski, Tassiana Ramires, Louise Haubert, Giulia Giugliani Reta, Rafael Gianella Mondadori, Wladimir Padilha da Silva, Rita de Cássia Dos Santos da Conceição, Eduarda Hallal Duval
Intense manipulation during beef jerky production increases the possibility of contamination with pathogenic microorganisms. This study evaluated the contamination by thermotolerant coliforms, Escherichia coli and Salmonella spp., on processing surfaces and raw materials during beef jerky production, as well as in the final product. Thermotolerant coliforms were found on all surfaces tested and in the raw material. Escherichia coli was identified in 6.7% of the surface samples, while Salmonella spp. was found in 3...
May 1, 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/28432607/impact-of-the-medical-specialty-on-knowledge-regarding-multidrug-resistant-organisms-and-strategies-toward-antimicrobial-stewardship
#12
Steffen Lebentrau, Christian Gilfrich, Malte W Vetterlein, Harald Schumacher, Philipp J Spachmann, Sabine D Brookman-May, Hans M Fritsche, Martin Schostak, Florian M Wagenlehner, Maximilian Burger, Matthias May
PURPOSE: Evidence is scarce on subject-specific knowledge of multidrug-resistant organisms and rational use of antibiotics. We aimed at evaluating attitude, perception, and knowledge about multidrug-resistant organisms (MDRO) and antibiotic prescribing among urologists versus other medical specialties. METHODS: Within the MR2-study (Multiinstitutional Reconnaissance of practice with MultiResistant bacteria), a questionnaire was conducted targeting general surgeons, internists, gynecologists, and urologists in 18 German hospitals...
April 21, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28423435/-pathogen-spectrum-of-complex-wounds-in-germany-from-war-zones
#13
Hans Joachim Riesner, Benedikt Friemert, Patricia Lang, Hans Georg Palm, Arnold J Suda
Background Treatment of the injured from war zones with wounds with multi-resistant pathogens is becoming more common in Germany, especially in German Armed Forces Hospitals. In most cases, the pre-treatment of these patients has been inadequate and they have a high load of rare pathogens. In Germany, hospitals have to evaluate these pathogens by law. The aim of this study was to review current German guidelines and data on the array of pathogens of complex trauma wounds in Germany and to compare patients with wounds and multi-resistant pathogens from war zones treated in Germany...
April 19, 2017: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/28419091/multidrug-resistant-bacteria-compensate-for-the-epistasis-between-resistances
#14
Jorge Moura de Sousa, Roberto Balbontín, Paulo Durão, Isabel Gordo
Mutations conferring resistance to antibiotics are typically costly in the absence of the drug, but bacteria can reduce this cost by acquiring compensatory mutations. Thus, the rate of acquisition of compensatory mutations and their effects are key for the maintenance and dissemination of antibiotic resistances. While compensation for single resistances has been extensively studied, compensatory evolution of multiresistant bacteria remains unexplored. Importantly, since resistance mutations often interact epistatically, compensation of multiresistant bacteria may significantly differ from that of single-resistant strains...
April 2017: PLoS Biology
https://www.readbyqxmd.com/read/28408938/bacteraemia-in-intensive-care-unit-clinical-bacteriological-and-prognostic-prospective-study
#15
Zineb Lachhab, Mohammed Frikh, Adil Maleb, Jalal Kasouati, Nouafal Doghmi, Yassine Ben Lahlou, Bouchra Belefquih, Abdelhay Lemnouer, Mostafa Elouennass
Objectives. We conducted a one-year observational study from December 2012 to November 2013 to describe the epidemiology of bacteraemia in intensive care units (ICU) of Mohammed V Military Teaching Hospital of Rabat (Morocco). Methods. The study consisted of monitoring all blood cultures coming from intensive care units and studying the bacteriological profile of positive blood cultures as well as their clinical significance. Results. During this period, a total of 46 episodes of bacteraemia occurred, which corresponds to a rate of 15,4/1000 patients...
2017: Canadian Journal of Infectious Diseases & Medical Microbiology
https://www.readbyqxmd.com/read/28407186/antimicrobial-activity-and-chemical-composition-of-brunfelsia-uniflora-flower-oleoresin-extracted-by-supercritical-carbon-dioxide
#16
L C T Thiesen, E Y Y Sugauara, V Tešević, J Glamočlija, M Soković, J E Gonçalves, Z C Gazim, G A Linde, N B Colauto
Brunfelsia genus is traditionally utilized in popular medicine due to its antibacterial and antifungal properties to name but a few. However, studies on the antimicrobial activity of Brunfelsia uniflora flower oleoresin have not been found yet. This study aimed to evaluate the chemical composition and antimicrobial activity of B. uniflora flower oleoresin obtained by supercritical carbon dioxide. Oleoresin from the plant dried flowers was obtained by carbon dioxide, and the chemical composition was analyzed by gas chromatographic-mass spectrometry...
April 13, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28397654/-infection-with-carbapenemase-producing-organisms-after-cosmetic-surgery-at-a-hospital-abroad
#17
Vigith Andrews, Anette M Hammerum, Niclas Dohrn, Barbara J Holzknecht
In Denmark, the incidence of carbapenemase-producing organisms (CPO) is increasing, and a coordinated national strategy is needed. We describe a case story of a 40-year-old woman transferred to a Danish hospital with severe complications after cosmetic surgery in the Middle East. She had an intra-abdominal infection with three different CPO, one of them co-resistant to colistin, one of the few remaining antibiotics for CPO treatment. Because of good clinical response to surgical treatment, antibiotics covering these multiresistant bacteria were not given...
March 27, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28391717/modulation-of-antibiotic-activity-by-the-hydroalcoholic-extract-from-leaves-of-caryocar-coriaceum-wittm
#18
Luís J de Lacerda Neto, A G B Ramos, M R Kerntopf, H D M Coutinho, L J Quintans-Junior, J R G S Almeida, J Ribeiro-Filho, I R A Menezes
The aim of this study was to identify the presence of tannins, phenols and flavonoids on the hydroalcoholic extract of Caryocar coriaceum leaves (HECCL) and to determine the antioxidant and antibacterial activity of this extract. The extract was tested alone (1024-1 μg/mL) or associated (MIC/8) with several antibiotics in order to identify any antibacterial activity against multiresistant bacterial strains (Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa). The existence of tannins, total phenols (901...
April 9, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28385578/rhaphiodon-echinus-nees-mart-schauer-chemical-toxicological-activity-and-increased-antibiotic-activity-of-antifungal-drug-activity-and-antibacterial
#19
Adrielle Rodrigues Costa, Juliana de Lima Silva, Kátia Regina Rodrigues Lima, Maria Ivaneide Rocha, Luiz Marivando Barros, José Galberto Martins da Costa, Aline Augusti Boligon, Jean Paul Kamdem, Joara Nalyda Pereira Carneiro, Nadghia Figueiredo Leite, Irwin Rose Alencar de Menezes, Antonia Eliene Duarte, Maria Flaviana Bezerra Morais-Braga, Henrique Douglas Melo Coutinho
The association of herbal products with standard antimicrobial drugs has recently gained more attention as a hope to overcome infectious diseases caused by multidrug-resistant microorganisms. Here, we investigated for the first time the antimicrobial (antifungal and antibacterial) activity of ethanolic and aqueous extracts of R. echinus against multiresistant strains of bacteria (E. coli, P. aeruginosa and S. aureus) and fungi (C. albicans, C. krusei and C. tropicalis), as well as potential to enhance the activity of antibiotics drugs...
April 4, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28380016/carbapenemase-producing-enterobacteriaceae-recovered-from-a-spanish-river-ecosystem
#20
Núria Piedra-Carrasco, Anna Fàbrega, William Calero-Cáceres, Thais Cornejo-Sánchez, Maryury Brown-Jaque, Alba Mir-Cros, Maite Muniesa, Juan José González-López
The increasing resistance to carbapenems is an alarming threat in the fight against multiresistant bacteria. The dissemination properties of antimicrobial resistance genes are supported by their detection in a diverse population of bacteria, including strains isolated from the environment. The objective of this study was to investigate the presence of carbapenemase-producing Enterobacteriaceae (CPE) collected from a river ecosystem in the Barcelona metropolitan area (Spain). Identification of β-lactamases and other resistance determinants was determined as was the antimicrobial susceptibility profile...
2017: PloS One
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