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Hector Rosas-Hernandez, Elvis Cuevas, Claudia Escudero-Lourdes, Susan M Lantz, Nasya M Sturdivant, Syed Z Imam, Sumit Sarkar, William Slikker, Merle G Paule, Kartik Balachandran, Syed F Ali
Traumatic brain injury (TBI) occurs when external mechanical forces induce brain damage as result of impact, penetration or rapid acceleration/deceleration that causes deformation of brain tissue. Depending on its severity, TBI can be classified as mild, moderate or severe and can lead to blood-brain barrier (BBB) dysfunction. In the present study, we evaluated the effects of uniaxial high-speed stretch (HSS) at 0, 5, 10 and 15% on a pure culture of primary rat brain endothelial cells as an in vitro model of TBI to the BBB...
February 16, 2018: Neuroscience Letters
Joseph D Morrison, Nasya Mendoza-Elias, Andrew J Lipnik, R Peter Lokken, James T Bui, Charles E Ray, Ron C Gaba
PURPOSE: To quantify and compare portosystemic pressure gradients (PSGs) between bleeding esophageal varices (EV) and gastric varices (GV). MATERIALS AND METHODS: In a single-center, retrospective study, 149 patients with variceal bleeding (90 men, 59 women, mean age 52 y) with EV (n = 69; 46%) or GV (n = 80; 54%) were selected from 320 consecutive patients who underwent successful transjugular intrahepatic portosystemic shunt (TIPS) creation from 1998 to 2016...
January 15, 2018: Journal of Vascular and Interventional Radiology: JVIR
Nasya Mendoza-Elias, Sophia F Shakur, Fady T Charbel, Ali Alaraj
OBJECTIVE: The pathogenesis of venous outflow stenosis associated with cerebral arteriovenous malformation (AVM) draining veins is poorly understood. We sought to determine the relationship between venous stenosis and atherosclerotic risk factors. MATERIALS AND METHODS: All patients with an AVM seen at our institution between 1990 and 2016 were retrospectively reviewed. Patients <18 years of age were excluded. Patients were classified into two groups based on the presence or absence of venous stenosis...
November 28, 2017: Journal of Neurointerventional Surgery
Kyle M Schachtschneider, Regina M Schwind, Jordan Newson, Nickolas Kinachtchouk, Mark Rizko, Nasya Mendoza-Elias, Paul Grippo, Daniel R Principe, Alex Park, Nana H Overgaard, Gregers Jungersen, Kelly D Garcia, Ajay V Maker, Laurie A Rund, Howard Ozer, Ron C Gaba, Lawrence B Schook
Despite an improved understanding of cancer molecular biology, immune landscapes, and advancements in cytotoxic, biologic, and immunologic anti-cancer therapeutics, cancer remains a leading cause of death worldwide. More than 8.2 million deaths were attributed to cancer in 2012, and it is anticipated that cancer incidence will continue to rise, with 19.3 million cases expected by 2025. The development and investigation of new diagnostic modalities and innovative therapeutic tools is critical for reducing the global cancer burden...
2017: Frontiers in Oncology
Hector Rosas-Hernandez, Elvis Cuevas, Claudia Escudero-Lourdes, Susan M Lantz, Nancy P Gomez-Crisostomo, Nasya M Sturdivant, Kartik Balachandran, Syed Z Imam, William Slikker, Merle G Paule, Syed F Ali
Traumatic brain injury (TBI) is one of the major causes of disability in the USA. It occurs when external mechanical forces induce brain damage that causes deformation of brain tissue. TBI is also associated with alterations of the blood-brain barrier (BBB). Using primary rat brain microvascular endothelial cells as an in vitro BBB model, the effects of biaxial stretch were characterized at 5, 10, 15, 25, and 50% deformation using a commercially available system. The results were compared to the effects of mild and moderate TBI in vivo, induced by the weight-drop method in mice...
August 25, 2017: Molecular Neurobiology
Ron C Gaba, Nasya Mendoza-Elias, Joseph D Morrison, Ali Kord Valeshabad, Andrew J Lipnik
Transarterial locoregional therapies (LRTs) are indispensable components of the modern interventional oncologic therapy of liver-dominant metastatic neuroendocrine tumors (NETs). The scope of available LRTs and their nuanced differences mandates a thorough understanding of their relative applicability and effectiveness in certain clinical circumstances to prescribe appropriate, patient-specific, image-guided therapy. This article aims to provide an overview of transarterial LRT options for liver-dominant metastatic NETs and therapy selection by reviewing procedure types, their advantages and disadvantages, and comparative efficacy in common case scenarios...
June 2017: Seminars in Interventional Radiology
Ngoc Lam, Hanh Lam, Nasya Sturdivant, Kartik Balachandran
The study of heart valve homeostatic and disease mechanisms are often limited by the challenges in simulating the in vivo milieu, where valve cells are surrounded by the extracellular matrix in a three dimensional environment and experience multiple dynamic mechanical forces. Type I collagen is typically the most common three dimensional matrix used to culture valve cells in vitro. Unfortunately, this material has poor mechanical behavior due to an inherent propensity to compact significantly, unlike native valve leaflets...
May 9, 2017: Biomedical Materials
Bhavesh K Ahir, Nasya M Elias, Sajani S Lakka
Medulloblastoma is the most common malignant brain tumor in children. SPARC (secreted protein acidic and rich in cysteine), a multicellular non-structural glycoprotein is known to be involved in multiple processes in various cancers. Previously, we reported that SPARC expression significantly impairs medulloblastoma tumor growth in vitro and in vivo and also alters chemo sensitivity. MicroRNAs are a class of post-transcriptional gene regulators with critical functions in tumor progression. In addition, microRNA (miRNA) expression changes are also involved in chemo-resistance...
January 2017: Genes & Cancer
Nasya B Tomlekova, Philip J White, Jacqueline A Thompson, Emil A Penchev, Stephan Nielen
Vitamin and mineral deficiencies are prevalent in human populations throughout the world. Vitamin A deficiency affects hundreds of millions of pre-school age children in low income countries. Fruits of pepper (Capsicum annuum L.) can be a major dietary source of precursors to Vitamin A biosynthesis, such as β-carotene. Recently, pepper breeding programs have introduced the orange-fruited (of) trait of the mutant variety Oranzheva kapiya, which is associated with high fruit β-carotene concentrations, to the mutant variety Albena...
2017: PloS One
Nasya M Sturdivant, Sean G Smith, Syed F Ali, Jeffrey C Wolchok, Kartik Balachandran
Non-penetrating or mild traumatic brain injury (mTBI) is commonly experienced in accidents, the battlefield and in full-contact sports. Astrocyte cellular edema is one of the major factors that leads to high morbidity post-mTBI. Various studies have reported an upregulation of aquaporin-4 (AQP4), a water channel protein, following brain injury. AZA is an antiepileptic drug that has been shown to inhibit AQP4 expression and in this study we investigate the drug as a therapeutic to mitigate the extent of mTBI induced cellular edema...
September 14, 2016: Scientific Reports
Rajkala S Ramteke, Panchakshari D Patil, Anup B Thakar
For emergency conditions, Ayurveda has never been given importance in recent times. However, there are certain emergency conditions where biomedicine has limitations but, Ayurveda can provide solution. Classics have many references regarding management of acute conditions like syncope, coma, episodic conditions of bronchial asthma, epilepsy, etc., In the present study, a 61 year female patient had a two year history of hypertension and was suffering with coma. She was treated with an Ayurvedic treatment modality...
April 2016: Ancient Science of Life
Ishita Tandon, Atefeh Razavi, Prashanth Ravishankar, Addison Walker, Nasya M Sturdivant, Ngoc Thien Lam, Jeffrey C Wolchok, Kartik Balachandran
Valve interstitial cells are dispersed throughout the heart valve and play an important role in maintaining its integrity, function, and phenotype. While prior studies have detailed the role of external mechanical and biological factors in the function of the interstitial cell, the role of cell shape in regulating contractile function, in the context of normal and diseased phenotypes, is not well understood. Thus, the aim of this study was to elucidate the link between cell shape, phenotype, and acute functional contractile output...
October 3, 2016: Journal of Biomechanics
Karen J Coleman, Tani Hemmila, Mark D Valenti, Nasya Smith, Rachel Quarrell, Lynnice K Ruona, Emily Brandenfels, Barbara Hann, Todd Hinnenkamp, Margarita D Parra, Jeyn Monkman, Sue Vos, Rebecca C Rossom
OBJECTIVE: To understand how care managers implemented COMPASS and if this was related to patient health outcomes. METHODS: A total of 96 COMPASS care managers were approached to participate in the online survey and 93 (97%) provided responses. Correlations were generated between key survey responses and the average number of care management contacts, patient depression, blood pressure and glycosylated hemoglobin outcomes. RESULTS: Patients of care managers who reported spending more time on COMPASS-related tasks had higher rates of depression improvement (r=0...
January 2017: General Hospital Psychiatry
Manuel Joseph Vivera, Judith Streak Gomersall
BACKGROUND: Ardita (facial paralysis) is a medical condition that disfigures or distorts the facial appearance of the sufferer causing facial asymmetry and malfunction. Ardita patients may benefit from considering alternative treatments such as Ayurveda, including Taila Nasya (nasal instillation of medicated oil). OBJECTIVES: To synthesize the best available evidence on the effectiveness of different Nasya oils in the treatment of Ardita. INCLUSION CRITERIA TYPES OF PARTICIPANTS: Studies conducted on adult sufferers (18-70 years) of Ardita (chronic or acute) in any setting were considered...
April 2016: JBI Database of Systematic Reviews and Implementation Reports
Sarvesh Kumar Singh, Kshipra Rajoria
Ankylosing spondylitis (AS) is a rheumatic disease with various skeletal and extra skeletal manifestations. No satisfactory treatment is available in modern medicine for this disorder. Various Panchakarma procedures and Ayurvedic drugs have been proved useful for these manifestations. We present a case of AS, which was treated for two months with a combination of Panchakarma procedures and Ayurvedic drugs. Ayurvedic treatments, in this case, were directed toward alleviating symptoms and to reduce severe disability...
March 2016: Journal of Ayurveda and Integrative Medicine
Manjusha Rajagopala, G Gopinathan
The term Shotha ordinarily means a swelling which may be because of inflammatory process in any part of the body or may be general, due to causes other than inflammatory. A diagnosed case of papilledema (Kapha-Pittaja Drishti Nadi Shotha) was treated on the lines of Shotha Chikitsa. The patient was given Dashamoola and Punarnavashtaka Kwatha internally and locally Nasya and Takradhara for 3 months. At the end of 3 months, papilledema completely regressed. Follow-up of the patient for more than 3 years, no recurrence has been reported...
April 2015: Ayu
B S Prasad, Deepa Patil, L G Pardeep, Veerayya Hiremath, C R Shreelakshmi
INTRODUCTION: Nasya karma is prime treatment modality for ūrdhvajatrugata vikāra. Though classics clearly mention yogya (arha), ayogya (anarha) criteria for Nasya karma some complications were noticed while practicing. In KLEUS Shri BMK Ayurveda Hospital Belgaum, out of 2867 patients 58 (0.58%) cases reported various complications during and after Nasya karma in the year of 2011 even after taking utmost care in selection of patients as well as drugs. This gave rise to need to develop quick screening criteria to minimize errors...
October 2014: Ancient Science of Life
David J Rademacher, Nasya Mendoza-Elias, Gloria E Meredith
Context-drug learning produces structural and functional synaptic changes in the circuitry of the basolateral nucleus of the amygdala (BLA). However, how the synaptic changes translated to the neuronal targets was not established. Thus, in the present study, immunohistochemistry with a cell-specific marker and the stereological quantification of synapses was used to determine if context-drug learning increases the number of excitatory and inhibitory/modulatory synapses contacting the gamma-aminobutyric acid (GABA) interneurons and/or the pyramidal neurons in the BLA circuitry...
January 2015: European Journal of Neuroscience
Katharina Stoelzel, Gordana Bothe, Pee Win Chong, Minoo Lenarz
BACKGROUND: Nasya/Prevalin is a natural, drug-free nasal spray for treatment and prevention of allergic rhinitis. Because of its thixotropic property, it forms a barrier on the nasal mucosa, preventing allergen contact. This study assesses the clinical efficacy and safety of Nasya/Prevalin in a nasal provocation test with house dust mite allergens. METHODOLOGY/PRINCIPAL: In this randomised, double-blind, placebo-controlled trial, 20 subjects suffering from allergic rhinitis because of house dust mite allergens received a single dose of Nasya/Prevalin or saline spray before allergen challenge...
October 2014: Clinical Respiratory Journal
Krupa R Donga, Shilpa B Donga, Laxmi Priya Dei
Description of Vandhyatva is available in most of the Ayurvedic classics, including Nidana (diagnosis), Samprapti (etiopathogenesis), Lakshana (symptomatology), Bheda (types) and Chikitsa (treatment). In current study, efforts have been made to study the effect of Nasya and Matra Basti on anovulation (Beeja Dushti). Ovulation is under the control of Vata. Narayana Taila is attributed for its effect in Vandhyatva. 24 patients of female infertility having anovulatory factor, being diagnosed by Trans-Vaginal Sonography (TVS) for 2 consecutive cycles were divided in two groups...
January 2013: Ayu
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