Gordon J Ruan, Saurabh Zanwar, Aishwarya Ravindran, Susan Schram, Jithma P Abeykoon, Antonious Hazim, Jason R Young, Mithun V Shah, N Nora Bennani, Liuyan Jiang, Diana Morlote, Karen L Rech, Gaurav Goyal, Ronald S Go
Malignant histiocytosis (MH) is an extremely rare neoplasm of the macrophage-dendritic cell lineage. We report the clinical characteristics, molecular aberrations, treatments, and outcomes of patients with MH seen at two referral centers from January 2000 to May 2023. We identified 43 patients with MH, of which 26 had histiocytic sarcoma (MH-H), 9 interdigitating dendritic cell sarcoma (MH-IDC), and 8 Langerhans cell sarcoma (MH-LC). The median age at diagnosis was 61 years (range, 3-83). Thirty-three patients (77%) had multifocal disease, while 10 had unifocal involvement...
February 26, 2024: American Journal of Hematology