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Salivary gland tumors

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https://www.readbyqxmd.com/read/29770587/an-unusual-case-of-pulmonary-hamartoma-with-predominant-bronchial-mucous-glands-in-the-peripheral-lung
#1
Rin Yamada, Akiko Tonooka, Shin-Ichiro Horiguchi, Toru Motoi, Horio Hirotoshi, Tsunekazu Hishima
Pulmonary hamartoma (PH) is the most common benign lung tumor, comprising various amounts of mescenchymal components with entrapped epithelial components. We describe an unusual case of PH in the left lower lung lobe of a 60-year-old female. The tumor was 9 × 9 mm in size, light brown, weakly glistening, and microscopically found to be composed of well-developed epithelial and mesenchymal components without atypia. Both components were intermingled but without apparent transition. Epithelial components were occupied by predominant bronchial mucous glands...
May 16, 2018: Pathology International
https://www.readbyqxmd.com/read/29768362/intraductal-papilloma-arising-from-the-accessory-parotid-gland-a-case-report-and-literature-review
#2
Shuai Sun, Panpan Wang, Yufan Wang, Wen Su, Feng Wang, Hongyu Yang
RATIONALE: Intraductal papillomas of the accessory parotid glands are extremely rare benign tumors that are most commonly derived from minor salivary glands and are easily misdiagnosed as other diseases. Studying these lesions by pathology and immunohistochemistry can raise awareness of the disease, reduce the rate of misdiagnosis, and provide more precise treatments. PATIENT CONCERNS: A 35-year-old man first presented to our hospital with a 6-month history of a painless mass on his left parotid gland...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29766278/adenomatous-ductal-proliferation-hyperplasia-in-the-parotid-gland-associated-without-any-other-pathological-lesions-a-report-and-survey-of-the-literatures
#3
Bhoj Raj Adhikari, Michiko Nishimura, Kosuke Takimoto, Fumiya Harada, Aya Onishi, Daichi Hiraki, Durga Paudel, Puja Neopane, Masafumi Utsunomiya, Tetsuro Morikawa, Koki Yoshida, Jun Sato, Mamata Shakya, Eiji Nakayama, Hiroki Nagayasu, Yoshihiro Abiko
Adenomatous ductal proliferation/hyperplasia (ADP/H) is a rare hyperplastic condition of the salivary gland. It is mostly associated with other salivary gland pathologies such as tumors and inflammations, and is incidentally found in tissue sections during histopathological examinations of those diseases. Herein, we report a case of ADP/H in the parotid gland not associated with any other pathological lesions, and present a review of the literature on this condition. A 60-year-old Japanese female complained of swelling on the left side of parotid region...
May 15, 2018: Medical Molecular Morphology
https://www.readbyqxmd.com/read/29760580/sinonasal-adenoid-cystic-carcinoma-role-of-on-site-fnac-a-case-report
#4
Santosh Tummidi, Kanchan Kothari, Roshni Patil, Shruti S Singhal, Vyoma Shah
Background: Adenoid cystic carcinoma (ACC), a rare tumor of epithelial cell origin, commonly arises from the major salivary glands. Uncommonly it may be found outside the salivary glands and it's especially rare in the nasal cavity. Case presentation: A 71-year female had complaints of swelling at the base of nose, Fine needle aspiration (FNA) from the swelling revealed features of adenoid cystic carcinoma; cell block & IHC for CD-117 was positive. Conclusions: Sino-nasal ACC (SNACC) continues to pose diagnostic and therapeutic challenges to clinicians...
2018: BMC Ear, Nose, and Throat Disorders
https://www.readbyqxmd.com/read/29755265/pleomorphic-adenoma-of-the-lacrimal-gland-a-review-with-updates-on-malignant-transformation-and-molecular-genetics
#5
REVIEW
William Harrison, Patricia Pittman, Thomas Cummings
Pleomorphic adenoma (benign mixed tumor) is the most common epithelial neoplasm of the lacrimal gland. It is usually a slow growing, well-circumscribed, mass that is identical to its salivary gland counterpart. Patients generally have an excellent prognosis for vision and long-term survival after complete surgical excision. There is a tendency to reoccur, especially if there is an incomplete excision, and rarely, malignant transformation to carcinoma ex pleomorphic adenoma can occur, which has a much poorer prognosis...
January 2018: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/29752049/the-screening-and-electron-microscopy-observation-of-mammary-analogue-secretory-carcinoma-in-chinese
#6
Yi Zhong, Liu Liu, Bin Qi, Xiaoling Song, Linhan Shen, Hongwei Li
Mammary analogue secretory carcinoma of salivary gland (MASC) is a tumor with histopathologic and immunophenotypic features mimicking secretory carcinoma of the breast harboring the ETV6 split. The expression of mammaglobin, S-100, Ki-67, P63 and ETV6 split were detected in twelve cases of acinar cell carcinoma and fourteen cases of mammary analogue secretory carcinoma of salivary gland by immunohistochemistry and fluorescence in situ hybridization respectively. The expression of ETV6 gene split was detected in fourteen mammary analogue secretory carcinomas of salivary gland with positive expression of mammaglobin...
October 19, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29749993/central-acinic-cell-carcinoma-of-the-mandible-simulating-as-benign-odontogenic-lesion-a-case-report
#7
Manas Bajpai, Nilesh Pardhe, Betina Chandolia, Manika Arora
Centrally occurring salivary gland tumors are rare. Because of a considerable overlap between the clinical and histopathological features, this group of tumors often produces a diagnostic difficulty to the clinicians and oral pathologists. Acinic cell carcinoma (ACC) is an unusual, low-grade, malignant salivary gland tumor that represents approximately 2% of the salivary gland tumors with almost 90% arising in the parotid gland. The rest involve the submandibular and the minor salivary gland. ACC of the jaw is extremely rare and, to our knowledge, only 8 cases have been reported in the English literature...
March 2018: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29738361/intraductal-papillary-mucinous-neoplasms-of-minor-salivary-glands-with-akt1-p-glu17lys-mutation
#8
Abbas Agaimy, Sarina K Mueller, Klaus Bumm, Heinrich Iro, Evgeny A Moskalev, Arndt Hartmann, Robert Stoehr, Florian Haller
The spectrum of low-grade intraductal papillary proliferations of the salivary glands is heterogenous, and reproducible morphologic diagnostic criteria have not yet been established. Recognized types are sialadenoma papilliferum, inverted ductal papilloma, and intraductal papilloma, but some lesions have been possibly included in the morphologic spectrum of cystadenoma or low-grade intraductal carcinomas. We herein present detailed morphologic, immunophenotypic, and genotypic features of 3 minor salivary gland neoplasms affecting 2 men (aged 65 and 71 y) and 1 woman (aged 78 y)...
May 5, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29734861/establishment-and-characterization-of-a-carcinoma-associated-fibroblast-cell-line-derived-from-a-human-salivary-gland-adenoid-cystic-carcinoma
#9
Jing Kong, Han Zhao, Qianhui Shang, Zhifei Ma, Ni Kang, Junling Tan, Hyat Ahmed Ibrahim Alraimi, Tingjiao Liu
Salivary gland adenoid cystic carcinoma (SACC) is one of the most common malignancies in the oral and maxillofacial region. Carcinoma-associated fibroblast (CAF) is an important component in the tumor microenvironment and participates in SACC progression. In this study, we established a CAF cell line derived from a human SACC and named it CAF-SA. It was identified that CAF-SA expressed typical CAF biomarkers. Then, we studied the cellular communications between CAF-SA, tumor cells and endothelial cells. It was found that CAF-SA promoted the migration, invasion, and proliferation of SACC tumor cells in vitro...
December 2018: Cell Communication & Adhesion
https://www.readbyqxmd.com/read/29734482/incompletely-treated-malignancies-of-the-major-salivary-gland-toward-evidence-based-care
#10
Samantha Tam, Vlad C Sandulache, Kareem A Metwalli, Crosby D Rock, Salman A Eraj, Tommy Sheu, Adel K El-Naggar, Clifton D Fuller, Randal S Weber, Stephen Y Lai
BACKGROUND: Unexpected malignancy is common in major salivary gland tumors due to variability of workup, creating challenging treatment decisions. The purpose of this study was to define treatment-related outcomes for patients with incompletely treated major salivary gland tumors. METHODS: A retrospective cohort study was completed of patients with incompletely treated major salivary gland tumors. Tumor burden at presentation was established and treatment categorized...
May 7, 2018: Head & Neck
https://www.readbyqxmd.com/read/29731974/genetic-rearrangements-hotspot-mutations-and-microrna-expression-in-the-progression-of-metastatic-adenoid-cystic-carcinoma-of-the-salivary-gland
#11
Simon Andreasen, Tina Klitmøller Agander, Kristine Bjørndal, Daiva Erentaite, Steffen Heegaard, Stine R Larsen, Linea Cecilie Melchior, Qihua Tan, Benedicte Parm Ulhøi, Irene Wessel, Preben Homøe
Adenoid cystic carcinoma (ACC) is among the most common salivary gland malignancies, and is notorious for its unpredictable clinical course with frequent local recurrences and metastatic spread. However, the molecular mechanisms for metastatic spread are poorly understood. This malignancy is known to frequently harbor gene fusions involving MYB , MYBL1 , and NFIB , and to have a low mutational burden. Most studies have focused on primary tumors to understand the biology of ACC, but this has not revealed a genetic cause for metastatic dissemination in the majority of cases...
April 13, 2018: Oncotarget
https://www.readbyqxmd.com/read/29731569/bibliometric-analysis-of-oral-and-maxillofacial-cytology-related-articles-published-in-a-cytology-journal-from-india
#12
Thorakkal Shamim
Background: There is a paucity of information about the oral and maxillofacial cytology-related articles published in a cytology journal. Journal of Cytology (JOC) is the official publication of Indian Academy of Cytologists. Objective: This study aimed to audit the oral and maxillofacial cytology-related articles published in JOC from 2007 to 2015 over a 9-year period. Materials and Methods: Bibliometric analysis of issues of JOC from 2007 to 2015 was performed using web-based search...
January 2018: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/29729907/technical-note-p40-antibody-as-a-replacement-for-p63-antibody-in-bovine-mammary-immunohistochemistry
#13
C L M Parsons, H L M Tucker, R M Akers, K M Daniels
Tumor protein 63 (p63) is a nuclear antigen found in basal epithelial cells. To date, 10 isoforms of p63 have been identified, falling into 2 major groups identified by presence or absence of an N-terminal transactivation domain (TAp63 and ΔNp63, respectively). Literature suggests that ΔNp63 is the predominant form expressed in basal epithelial cells and myoepithelial cells (MYEC). The mouse anti-p63 antibody, clone 4B1E12, has been used as a specific nuclear marker for bovine MYEC. Unfortunately, this antibody is no longer commercially available...
May 2, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29728539/immunohistochemical-detection-of-proliferative-marker-ki-67-in-benign-and-malignant-salivary-gland-tumors
#14
Smita Bussari, Sindhu M Ganvir, Manish Sarode, Prabhakar A Jeergal, Anjum Deshmukh, Himanshu Srivastava
Introduction: Salivary gland tumors are the most histologically heterogeneous group of tumors with the greatest diversity of morphologic features among their cells and tissues. The present study was aimed at assessing the validity of Ki-67, a cell proliferation marker, as a prognostic factor in benign and malignant salivary gland tumors and to study whether it is related to age, sex, anatomical site, and size of the lesion in salivary gland tumors. Materials and methods: A retrospective study consisted of benign salivary gland tumors (BSGTs) (n = 15), malignant salivary gland tumors (n = 18), and normal salivary gland parenchyma (n = 15)...
April 1, 2018: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/29728174/sialoblastoma-in-chin-and-management-of-treatment
#15
Qian Wang, Sainan Ma, Huanhuan Chen, Mingli Yang, Weisong Cai
OBJECTIVE: Sialoblastoma is a rare salivary gland tumor mainly located in parotid. In this article, we aimed to review the clinical manifestations and treatments of sialoblastoma, especially to provide effective chemotherapy regimens to instruct internal medicine therapy for unresectable or recurrent tumors. METHOD: We reported a 1-year old girl who presented a left-sided firm facial mass and subsequently diagnosed as sialoblastoma. Afterwards, we reviewed and analyzed relevant literatures...
June 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29726401/adaptation-of-stochastic-microdosimetric-kinetic-model-for-charged-particle-therapy-treatment-planning
#16
T Inaniwa, N Kanematsu
The microdosimetric kinetic (MK) model underestimates the cell-survival fractions for high linear energy transfer (LET) and high dose irradiations. To address the issue, some researchers previously extended the MK model to the stochastic microdosimetric kinetic (SMK) model. In the SMK model, the radiation induced cell-survival fractions were estimated from the specific energies z d and z n absorbed by a microscopic subnuclear structure domain and a cell nucleus, respectively. By taking the stochastic nature of z n as well as that of z d into account, the SMK model could reproduce the measured cell-survival fractions for radiations with wide LET and dose ranges...
May 4, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29719073/the-expression-of-programed-death-ligand-1-could-be-related-with-unfavorable-prognosis-in-salivary-duct-carcinoma
#17
Fumihiko Sato, Jun Akiba, Akihiko Kawahara, Yoshiki Naito, Takeharu Ono, Yorihiko Takase, Kazuya Murata, Hideyuki Abe, Tomohiko Yamaguchi, Hiroaki Miyoshi, Yushi Abe, Yutaro Mihara, Masahiko Tanikawa, Momoko Akashi, Hirofumi Kurose, Hirohito Umeno, Hirohisa Yano
BACKGROUND: Salivary duct carcinoma (SDC) is a rare tumor occurring in the salivary gland. SDC is a highly aggressive tumor and its prognosis is extremely poor. Effective treatments in advanced SDC have not yet been established. Recently, immune checkpoint inhibitors have paved the way for the treatment of various malignancies. We examined the expressions of programed death ligand (PD-L) 1/PD-L2 and programed death (PD-1), and the correlation of clinicopathological findings. METHODS: We examined 18 cases of SDC and conducted immunohistochemical staining using formalin-fixed paraffin-embedded full-face sections...
May 2, 2018: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/29715110/human-polyomaviruses-are-not-frequently-present-in-cancer-of-the-salivary-glands
#18
Torbjörn Ramqvist, Ramona Gabriela Ursu, Linnea Haeggblom, Leila Mirzaie, Caroline Gahm, Lalle Hammarstedt-Nordenvall, Tina Dalianis, Anders Näsman
BACKGROUND/AIM: Malignant tumors of the salivary glands are rare and heterogeneous, with more than 20 subtypes, and classified mainly by histopathology. Their diagnosis is often challenging and their etiology unknown. Here, the possible association between human polyomaviruses (PyVs) and one or more salivary gland tumor subtypes was examined. MATERIALS AND METHODS: Ninety-one primary tumors, including 12 subtypes and eight corresponding metastases, were analyzed for the presence of DNA of 10 different human PyV species by a bead-based multiplex assay using polymerase chain reaction and Luminex analyses...
May 2018: Anticancer Research
https://www.readbyqxmd.com/read/29705927/single-nucleotide-polymorphism-rs11614913-associated-with-cc-genotype-in-mir-196a2-is-overrepresented-in-laryngeal-squamous-cell-carcinoma-but-not-salivary-gland-tumors-in-polish-population
#19
Marcin Skalski, Adam Ustaszewski, Katarzyna Jaskiewicz, Katarzyna Kiwerska, Malgorzata Wierzbicka, Hanna Klimza, Reidar Grenman, Maciej Giefing
The miRNA-196a2 has shown significance in the development of various neoplasms, including head and neck squamous cell carcinoma (HNSCC). The oncogenic functionality of this miRNA is mediated via its potential to target annexin A1 mRNA, a tumor suppressor gene involved in inhibition of the NF-κB pathway. Interestingly, recent data indicate a susceptibility for aforementioned neoplasms in patients with the CC genotype vs the CT and TT genotypes of the rs11614913 SNP located within the DNA sequence of the miR-196a2 that results in elevated expression of the gene...
April 29, 2018: Journal of Applied Genetics
https://www.readbyqxmd.com/read/29703045/a-feasibility-and-safety-study-of-concurrent-chemotherapy-based-on-genetic-testing-in-patients-with-high-risk-salivary-gland-tumors-preliminary-results
#20
Rongrong Li, Shengjin Dou, Min Ruan, Chenping Zhang, Guopei Zhu
BACKGROUND: This prospective study was conducted to evaluate the feasibility and safety of customized chemotherapy regimens based on the gene characteristics of salivary gland tumors. METHODS: Patients were enrolled with histologically confirmed intermediate or high grade, stage T3-4, N1-3 disease, and T1-2, N0 patients with a close (≤1 mm) or microscopically positive surgical margin were also enrolled in the study. All patients received radical surgery and postoperative concurrent chemoradiotherapy...
April 2018: Medicine (Baltimore)
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