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Hypopharyngeal cancer

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https://www.readbyqxmd.com/read/28087965/hypopharyngeal-cancer-masquerading-as-a-thyroid-mass
#1
P S Heng, M Irfan
Hypopharyngeal cancer (HPC) is generally a rare head and neck malignancy. There are differing clinical presentations depending on the subsite location of primary tumour. Advanced HPC will have neck node metastasis particularly upper jugulodigastric nodes. We report a patient with postcricoid tumour who presented with anterior huge neck swelling mimic thyroid mass. The patient first presented to the General Surgical Unit for management of presumed thyroid lesion. She was diagnosed post-cricoid squamous cell carcinoma when further assessed by otorhinolaryngologist...
December 2016: Medical Journal of Malaysia
https://www.readbyqxmd.com/read/28062933/single-cycle-induction-chemotherapy-for-resectable-advanced-hypopharyngeal-cancer
#2
Torahiko Nakashima, Ryuji Yasumatsu, Kaori Asai, Hideoki Uryu, Ryunosuke Kogo, Takashi Nakagawa
BACKGROUND: The role of induction chemotherapy (IC) in the treatment of resectable advanced head and neck squamous cell carcinoma has not been elucidated, and the most effective IC regimen for chemoselection is still unknown. At our institute we have not used the triple combination of docetaxel, cisplatin, fluorouracil (TPF) for chemoselection, but rather the double combination of docetaxel + cisplatin (TP). The aim of this study is to report the outcome of patients with advanced hypopharyngeal cancer treated by single cycle of IC with TP followed by chemoradiation (CRT) or surgery...
January 6, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28033526/induction-chemotherapy%C3%A2-followed-by-radiotherapy-for-larynx-preservation-in-advanced-laryngeal-and-hypopharyngeal-cancer-outcome-prediction-after-one-cycle-induction-chemotherapy-by-a-score-based-on-clinical-evaluation-computed-tomography-based-volumetry%C3%A2-and
#3
Gunnar Wichmann, Anne Krüger, Andreas Boehm, Marlen Kolb, Mathias Hofer, Milos Fischer, Stefan Müller, Sandra Purz, Patrick Stumpp, Osama Sabri, Andreas Dietz, Regine Kluge
BACKGROUND: Long-term laryngectomy-free (LFS), tumour-specific (TSS) and overall survival (OS) is achieved by non-surgical larynx preservation (LP) only in a proportion of patients with locally advanced laryngeal or hypopharyngeal cancer. A score facilitating decision-making after 1 cycle induction chemotherapy (IC-1) may improve LFS and TSS. METHODS: Early response to IC-1 with TPF ± cetuximab was assessed in 52 patients using endoscopic tumour staging for selecting total laryngectomy for non-responders with endoscopic tumour surface shrinkage <30% versus induction chemotherapy plus radiotherapy (IC + RT) for responders...
December 26, 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/28030898/early-hypopharyngeal-cancer-treated-with-different-therapeutic-approaches-a-single-institution-cohort-analysis
#4
Nalee Kim, Jeongshim Lee, Kyung Hwan Kim, Jong Won Park, Chang Geol Lee, Ki Chang Keum
PURPOSE: Early hypopharyngeal squamous cell carcinoma (HPSCC) is a rarely diagnosed disease, for which the optimal treatment has not been defined yet. We assessed patterns of failure and outcomes in early HPSCC treated with various therapeutic approaches to identify its optimal treatment. MATERIALS AND METHODS: Thirty-six patients with stage I (n = 10) and II (n = 26) treated between January 1992 and March 2014 were reviewed. Patients received definitive radiotherapy (RT) (R group, n = 10), surgery only (S group, n = 19), or postoperative RT (PORT group, n = 7)...
December 2016: Radiation Oncology Journal
https://www.readbyqxmd.com/read/28008394/does-opium-dependency-affect-the-pattern-of-involvement-in-laryngeal-cancer
#5
Peyman Dabirmoghaddam, Ali Karimian Taheri, Hosein Ghazavi, Shaghayegh Ebrahimnejad, Zahra Karimian
INTRODUCTION: Laryngeal cancer is the second most common cancer involving the respiratory tract, second only to lung cancer. Previous studies have shown opium dependency to be a possible risk factor for laryngeal cancer. Opium consumption is a major problem in some parts of the world. The aim of this study was to investigate the effect of opium consumption on the pattern of involvement in laryngeal cancer. METHODS AND MATERIALS: In this analytical cross-sectional study, 44 patients diagnosed with laryngeal cancer (41 male and three female) were studied...
November 2016: Iranian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28001302/impact-of-concomitant-chemoradiation-on-survival-for-patients-with-t1-2n1-head-and-neck-cancer
#6
Zachary S Zumsteg, Sungjin Kim, John M David, Emi J Yoshida, Mourad Tighiouart, Stephen L Shiao, Kevin Scher, Alain Mita, Eric J Sherman, Nancy Y Lee, Allen S Ho
BACKGROUND: Single-modality radiotherapy is considered a standard-of-care option for certain stage III, T1-2N1 head and neck squamous cell carcinomas (HNSCCs). The role of concomitant chemoradiation is not well established because there have been no studies comparing chemoradiation with radiation alone in this population. METHODS: This study analyzed patients in the National Cancer Data Base with cT1-2N1M0 invasive squamous cell carcinomas of the oropharynx, larynx, and hypopharynx who were diagnosed between 2004 and 2012 and were undergoing definitive radiation...
December 21, 2016: Cancer
https://www.readbyqxmd.com/read/27999896/correlation-of-pretreatment-18-f-fdg-pet-tumor-textural-features-with-gene-expression-in-pharyngeal-cancer-and-implications-for-radiotherapy-based-treatment-outcomes
#7
Shang-Wen Chen, Wei-Chih Shen, Ying-Chun Lin, Rui-Yun Chen, Te-Chun Hsieh, Kuo-Yang Yen, Chia-Hung Kao
PURPOSE: This study investigated the correlation of the matrix heterogeneity of tumors on (18)F-fluorodeoxyglucose positron emission tomography-computed tomography (PET-CT) with gene-expression profiling in patients with pharyngeal cancer and determined the prognostic factors for radiotherapy-based treatment outcomes. METHODS: We retrospectively reviewed the records of 57 patients with stage III-IV oropharyngeal or hypopharyngeal cancer who had completed definitive therapy...
December 20, 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27988198/primary-total-laryngectomy-and-pharyngolaryngectomy-in-t4-pharyngolaryngeal-cancers-oncologic-and-functional-results-and-prognostic-factors
#8
M Roux, O Dassonville, M Ettaiche, E Chamorey, G Poissonnet, A Bozec
OBJECTIVES: The aims of this study were to assess oncologic and functional outcome in primary total laryngectomy or pharyngolaryngectomy (TL/TL/TPL) for laryngeal or hypopharyngeal cancer with extra-laryngeal extension (T4) and to determine the predictive factors of these results. MATERIAL AND METHODS: A retrospective analysis was performed on the computerized medical records of all patients undergoing primary TL/TPL for T4 larynx or hypopharynx squamous cell carcinoma between 2000 and 2014 at our institution...
December 14, 2016: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/27976979/vocal-function-after-transoral-videolaryngoscopic-surgery-tovs-for-hypopharyngeal-and-supraglottic-cancer
#9
Shingo Tanaka, Masayuki Tomifuji, Koji Araki, Kosuke Uno, Yuya Tanaka, Daisuke Mizokami, Hiroshi Suzuki, Yoshihiro Miyagawa, Shinichi Taniai, Akihiro Shiotani
CONCLUSION: The resection of the medial and lateral pyriform sinus was associated with post-operative voice impairment after TOVS. Scar contracture around the cricoarytenoid joint lead to arytenoid fixation toward lateral position, and this wound healing process caused insufficient glottis closure. Although oncological and functional outcomes of TOVS was satisfactory, surgeons should mention the risk of post-operative voice impairment in pre-operative counseling. OBJECTIVES: Transoral surgery is a minimally invasive treatment option for hypopharyngeal and supraglottic cancer...
December 15, 2016: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/27922696/down-syndrome-critical-region-1-positively-correlates-with-angiogenesis-in-hypopharyngeal-cancer
#10
Chao Lv, Dayu Liu, Xiaona Wei
Hypopharyngeal carcinoma has one of the highest mortality rates of head and neck cancer, therefore, the identification of markers associated with the pathogenesis and development of hypopharyngeal cancer is critical. Down syndrome critical region 1 (DSCR1) is associated with carcinogenesis and tumor growth in several types of malignancy. Activation of the vascular endothelial growth factor (VEGF) signaling pathway upregulates DSCR1. The aims of the present study were to determine the expression levels of DSCR1 and VEGF‑C in hypopharyngeal cancer, and investigate the association between DSCR1 and angiogenesis in the disease...
January 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27919985/clinical-outcomes-of-definitive-and-postoperative-radiotherapy-for-stage-i-ivb-hypopharyngeal-cancer
#11
Katsuyuki Shirai, Jun-Ichi Saitoh, Atsushi Musha, Takanori Abe, Daijiro Kobayashi, Yosuke Takakusagi, Yukihiro Takaysu, Masato Shino, Minoru Toyoda, Katsumasa Takahashi, Kazuaki Chikamatsu, Tatsuya Ohno, Takashi Nakano
BACKGROUND: Hypopharyngeal cancer is relatively rare disease and continues to have a poor prognosis. This study analyzed the efficacy and safety of radiotherapy for stage I-IVB hypopharyngeal cancer. PATIENTS AND METHODS: Between 2000 and 2015, 72 patients were treated with definitive radiotherapy and 29 patients with stage IVA were treated with postoperative radiotherapy. RESULTS: With definitive radiotherapy, the 3-year locoregional control rates for stage I-II, III, IVA, and IVB disease were 89%, 74%, 51% and 0%, respectively...
2016: Anticancer Research
https://www.readbyqxmd.com/read/27916282/repair-of-complex-pharyngocutaneous-fistula-using-a-staged-temporoparietal-fascial-flap
#12
Nicholas B Abt, Priya Srikanth, Sidharth V Puram, Daniel G Deschler
INTRODUCTION: PCF is the most common major complication after salvage total laryngectomy (TL), especially for previously irradiated patients with laryngeal or hypopharyngeal cancer. METHODS/RESULTS: A 65-year-old woman presented with recurrent bilateral supraglottic SCC requiring salvage TL 5.5years after initial T1N0M0 epiglottic SCC resection. Her post-operative course was complicated by PCF development one month post-operatively and surgical fistula closure was delayed for adjuvant chemoradiotherapy...
November 25, 2016: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/27904706/the-central-role-of-hotair-in-the-malignancy-of-cd44-human-hypopharyngeal-carcinoma-cells
#13
Hongxia Cheng, Xinhua Cui, Ying Guo, Lintao Gu, Yaning Wang, Qirong Wang, Hui Liang
Human hypopharyngeal carcinoma is one of the most common malignant tumors. CD44 could serve as a molecular marker to screen for cancer stem cells (CSCs) in hypopharyngeal cancer. The aim of this study was to identify the role of HOX transcript antisense RNA (HOTAIR) on cell proliferation and invasion in CD44+ FADU cells (human hypopharyngeal carcinoma cells). We also explored the underlying mechanism contributing to HOTAIR's observed effects. CD44+ FADU cells were sorted and purified by flow cytometry and infected with lentivirus stably expressing HOTAIR shRNA...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27880017/comparison-of-the-outcomes-of-free-jejunal-flap-reconstructions-of-pharyngoesophageal-defects-in-hypopharyngeal-cancer-and-corrosive-injury-patients
#14
Mu-Han Hsieh, Yun-Tai Yang, Yueh-Ju Tsai, Yur-Ren Kuo, Pao-Yuan Lin
INTRODUCTION: Free jejunal flap is one of the optimal choices for restoring upper digestive tract. The purpose of this study was to introduce the treatment strategies and to compare the outcomes of free jejunal flap for pharyngoesophageal reconstruction between hypopharyngeal cancer and chemical corrosive injured esophagus. METHODS: From 2001 to 2012, patients who had been received esophageal reconstruction by free jejunal flap for pharyngoesophageal defect were divided into squamous cell carcinoma (SCC) group and corrosive chemical injury (CCI) group...
November 23, 2016: Microsurgery
https://www.readbyqxmd.com/read/27871805/the-survival-rate-and-larynx-preservation-in-elderly-cancer-patients-who-received-surgical-operation-a-retrospective-cohort-study
#15
Qin Wang, Yehai Liu, Guoqin Hu, Ruokun Wang, Yi Zhao, Ming Zhang
BACKGROUND: To investigate the efficiency of surgical operation for patients over 70 years with hypopharyngeal cancer. MATERIALS AND METHODS: A retrospective analysis of the medical records from 68 patients over 70 years-old with hypopharyngeal cancer who underwent different therapeutic regimen between 2000 and 2009 was conducted. 36 of 68 patients underwent larynx preservation. All patients were treated with surgical operation and adjuvant radiotherapy. A Kaplan-Meier method was employed to calculate the survival rate...
December 2016: International Journal of Surgery
https://www.readbyqxmd.com/read/27859415/predictors-of-survival-in-posterior-cricoid-squamous-cell-carcinoma-a-study-of-248-cases
#16
Hassieb A Din, Kevin Y Zhan, Caitlin Boling, Shaun Nguyen, Eric J Lentsch
OBJECTIVES: We aimed to describe the presentation, treatment patterns, and survival characteristics of posterior cricoid squamous cell carcinoma (SCC) with the National Cancer Database (NCDB). STUDY DESIGN: Retrospective database review. METHODS: We reviewed the NCDB from 2004 to 2013. Primary, previously untreated cases of posterior cricoid SCC were studied. Cox regression analysis was performed to look for prognostic factors. RESULTS: Out of 14,416 hypopharyngeal malignancies, 269 (1...
November 9, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27856033/salvage-transoral-videolaryngoscopic-surgery-for-radiorecurrent-hypopharyngeal-and-supraglottic-cancer
#17
Masayuki Tomifuji, Koji Araki, Taku Yamashita, Akihiro Shiotani
OBJECTIVE: To evaluate the feasibility of Transoral Videolaryngoscopic Surgery (TOVS) for radiorecurrent supraglottic and hypopharyngeal cancer, and to compare survival and complications between primary and radiorecurrent cases. METHODS: Twelve cases of salvage TOVS for radiorecurrent cancer and 53 cases of TOVS as an initial treatment (primary cases) were evaluated. Days to resume soft diet, Functional Outcomes of Swallowing Scale (FOSS), postoperative complications, epithelization days and survival outcomes were assessed by retrospective chart review...
November 14, 2016: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/27847320/inhibition-of-cdk9-induces-apoptosis-and-potentiates-the-effect-of-cisplatin-in-hypopharyngeal-carcinoma-cells
#18
Shengda Cao, Yingyi Yu, Shangren Chen, Dapeng Lei, Shudong Wang, Xinliang Pan, Jun Peng
Myeloid cell leukemia-1 (Mcl-1) plays an important role in survival, chemo- and radioresistance of head and neck squamous cell carcinoma (HNSCC). Cyclin-dependent kinase 9/cyclin T (CDK9) promotes excessive production of multiple pro-survival proteins including Mcl-1, leading to impaired apoptosis of cancer cells. As such, CDK9 is an emerging therapeutic target in cancer therapy. We herein report the first study of targeting CDK9 as a treatment strategy for hypopharyngeal squamous cell carcinoma (HSCC), an aggressive malignancy associated with one of the worst prognoses within HNSCC...
January 22, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27803615/corrigendum-did-the-addition-of-concomitant-chemotherapy-to-radiotherapy-improve-outcomes-in-hypopharyngeal-cancer-a-population-based-study
#19
S F Hall, R Griffiths
[This corrects the article on p. 266 in vol. 23, PMID: 27536177.].
October 2016: Current Oncology
https://www.readbyqxmd.com/read/27801961/heterogeneous-impact-of-drinking-according-to-treatment-method-on-survival-in-head-and-neck-cancer-a-prospective-study
#20
Michi Sawabe, Hidemi Ito, Isao Oze, Satoyo Hosono, Daisuke Kawakita, Hideo Tanaka, Yasuhisa Hasegawa, Shingo Murakami, Keitaro Matsuo
Alcohol consumption is an established risk factor, and also a potential prognostic factor, for squamous cell carcinoma of the head and neck (HNSCC). However, little is known about whether the prognostic impact of alcohol consumption differs by treatment modality. Here, we evaluated the association between alcohol drinking and survival by treatment method to the primary site in 427 patients with HNSCC treated between 2005-2013 at Aichi Cancer Center Central Hospital. The impact of alcohol on prognosis was measured by multivariable Cox regression adjusted for established prognostic factors...
November 1, 2016: Cancer Science
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