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Hypopharyngeal cancer

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https://www.readbyqxmd.com/read/28903378/ago2-involves-the-malignant-phenotypes-and-fak-pi3k-akt-signaling-pathway-in-hypopharyngeal-derived-fadu-cells
#1
Yanhui Zhang, Baoxin Wang, Xinwei Chen, Weidong Li, Pin Dong
Argonaute 2 (AGO2) protein is usually overexpressed in various head and neck squamous cell carcinoma. However, the precise molecular mechanisms of AGO2 in hypopharyngeal cancer have not yet been clearly understood. Here we found the AGO2 expression in hypopharyngeal cancer tissues were generally higher comparing with that of the corresponding adjacent noncancerous epithelium tissues, and these were associated with the more aggressive clinicopathologic features and the poor clinical outcomes. Stable knockdown of AGO2 protein retarded cell proliferation, migration, invasion, arrested cell cycle and induced apoptosis...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28900521/effectiveness-of-ultrasonography-and-computed-tomography-in-assessing-thyroid-cartilage-invasion-in-laryngeal-and-hypopharyngeal-cancers
#2
Nilu Malpani Dhoot, B Choudhury, A C Kataki, L Kakoti, S Ahmed, J Sharma
OBJECTIVE: To evaluate the adequacy of ultrasonography (US) and computed tomography (CT) in the assessment of thyroid cartilage invasion in patients with airway cancer. MATERIALS AND METHODS: Sixty-two consecutive patients referred to our institute underwent US and CT to stage laryngeal (n = 27) or hypopharyngeal (n = 35) cancer in this prospective study. Two radiologists, who were blinded to the patients' clinical histories and histopathology, evaluated thyroid cartilage invasion on US and CT separately and independently...
September 2017: Journal of Ultrasound
https://www.readbyqxmd.com/read/28894820/indwelling-voice-prosthesis-insertion-after-total-pharyngolaryngectomy-with-free-jejunal-reconstruction
#3
Hirofumi Fukushima, Takeharu Kanazawa, Kazuyoshi Kawabata, Hiroki Mitani, Hiroyuki Yonekawa, Toru Sasaki, Wataru Shimbashi, Akira Seto, Ryousuke Kamiyama, Kiyoshi Misawa, Takahiro Asakage
OBJECTIVES: Total pharyngolaryngectomy with free jejunal reconstruction is often performed in patients with hypopharyngeal carcinoma. However, postoperative speechlessness significantly decreases patient quality of life. We investigated whether Provox® insertion could preserve speech after total pharyngolaryngectomy with free jejunal reconstruction. STUDY DESIGN: Retrospective chart review. METHODS: A total of 130 cases of secondary Provox® insertions after total pharyngolaryngectomy with free jejunal reconstruction were analyzed...
February 2017: Laryngoscope Investigative Otolaryngology
https://www.readbyqxmd.com/read/28875745/age-adjusted-charlson-comorbidity-index-predicts-prognosis-of-laryngopharyngeal-cancer-treated-with-radiation-therapy
#4
Kazuya Takemura, Yukinori Takenaka, Naoki Ashida, Kotaro Shimizu, Ryohei Oya, Takahiro Kitamura, Yoshifumi Yamamoto, Atsuhiko Uno
OBJECTIVES: To examine the ability of comorbidity indices to predict the prognosis of laryngopharyngeal cancer and their association with treatment modalities. METHODS: This retrospective study included 198 patients with laryngeal, hypopharyngeal, and oropharyngeal cancers. The effect of comorbidity indices on overall survival between surgery and (chemo)-radiation therapy ((C)RT) groups was analyzed. The cumulative incidence rates for cancer mortality and other mortalities according to the age-adjusted Charlson Comorbidity Index (ACCI) and Charlson Comorbidity Index (CCI) were compared...
September 6, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28865840/efficacy-of-the-myofascial-pectoralis-major-flap-in-the-reduction-of-salivary-fistulas-after-salvage-total-laryngectomy
#5
Carlos Miguel Chiesa Estomba, Jose Angel González García, Jon Alexander Sistiaga Suarez, Izaskun Thomas Arrizabalaga, Ekhiñe Larruscain Sarasola, Xabier Altuna Mariezcurrena
INTRODUCTION: Pharyngocutaneous fistula is the most frequent complication after total laryngectomy. Its incidence varies between 9%-25% in post primary total laryngectomy patients, to 14%-57% in salvage laryngectomy post radiotherapy or post chemotherapy + radiotherapy. The pectoralis major myofascial flap (PMMF)is postulated as a useful tool to decrease the incidence of this complication. MATERIALS AND METHOD: Retrospective analysis of a group of patients treated by salvage laryngectomy, associated or not with pharyngeal closure reinforcement with PMMF...
August 30, 2017: Acta Otorrinolaringológica Española
https://www.readbyqxmd.com/read/28851901/investigating-the-association-between-alcohol-and-risk-of-head-and-neck-cancer-in-taiwan
#6
Cheng-Chih Huang, Jenn-Ren Hsiao, Wei-Ting Lee, Yao-Chou Lee, Chun-Yen Ou, Chan-Chi Chang, Yu-Cheng Lu, Jehn-Shyun Huang, Tung-Yiu Wong, Ken-Chung Chen, Sen-Tien Tsai, Sheen-Yie Fang, Jiunn-Liang Wu, Yuan-Hua Wu, Wei-Ting Hsueh, Chia-Jui Yen, Shang-Yin Wu, Jang-Yang Chang, Chen-Lin Lin, Yi-Hui Wang, Ya-Ling Weng, Han-Chien Yang, Yu-Shan Chen, Jeffrey S Chang
Although alcohol is an established risk factor of head and neck cancer (HNC), insufficiencies exist in the literature in several aspects. We analyzed detailed alcohol consumption data (amount and type of alcoholic beverage) of 811 HNC patients and 940 controls to evaluate the association between alcohol and HNC by HNC sites and by genotypes of ADH1B and ALDH2. Alcohol was associated with an increased HNC risk in a dose-response relationship, with the highest risk observed for hypopharyngeal cancer, followed by oropharyngeal and laryngeal cancers...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28843218/clinicopathologic-findings-and-treatment-outcome-of-laryngectomized-patients-with-laryngeal-cancer-and-hypopharyngeal-cancer-an-experience-in-thailand
#7
Noppadol Larbcharoensub, Duangkamon Wattanatranon, Juvady Leopairut, Suwimon Suntisuktana, Boonsam Roongpupaht, Chalermchai Chintrakarn, Jumroon Tungkeeratichai, Phurich Praneetvatakul, Thongchai Bhongmakapat, Wichit Cheewaruangroj, Supawadee Prakunhungsit
Objective: To evaluate the clinicopathologic findings and treatment outcome in laryngectomized patients with laryngeal cancer and hypopharyngeal cancer. Materials and Methods: The authors retrospectively reviewed the medical records of 212 patients who had been newly diagnosed and treated with laryngectomy between January 2000 and December 2010. The age, gender, clinical manifestations, associated predisposing condition, tumor WHO grade, AJCC tumor stage, maximum tumor size, anatomical involvement, type of surgery, postoperative sequelae, treatment and therapeutic outcome were analyzed...
August 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28841541/use-of-the-liver-maximum-function-capacity-test-limax-for-the-management-of-liver-resection-in-cirrhosis-a-case-of-hypopharyngeal-cancer-liver-metastasis
#8
S Cammann, F Oldhafer, K I Ringe, W Ramackers, K Timrott, M Kleine, J Klempnauer, F Lehner, H Bektas, F W R Vondran
INTRODUCTION: The presence of liver cirrhosis goes along with a higher chance for the need of liver resection. As established laboratory parameters often underestimate the degree of cirrhosis this is associated with an increased risk for postoperative liver failure due to the preoperatively impaired liver function. Known liver function tests are unlikely to be performed in daily use because of high cost or expenditure of time. Liver maximum function capacity test (LiMAx) provides a novel tool for measurement of liver function and references for the safety of liver resection...
August 10, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28832174/-intensity-modulated-hyperfractionated-accelerated-radiotherapy-to-treat-advanced-head-and-neck-cancer-predictive-factors-of-overall-survival
#9
J Cvek, L Knybel, J Stránský, P Matoušek, O Res, K Zeleník, B Otáhal, L Molenda, E Skácelíková, N Stieberová, Z Čermáková, D Feltl
AIM: The aim of this study was to evaluate overall survival (OS) and prognostic factors in patients ineligible for chemotherapy who were treated with a hyperfractionated accelerated schedule with simultaneous integrated boost. MATERIAL AND METHODS: From May, 2008, to April, 2013, 122 patients with locally advanced nonmetastatic squamous laryngeal (14%), hypopharyngeal (30%), oropharyngeal (30%), and oral cavity (27%) cancer were treated at our institution. The median age, Karnofsky Performance Status (KPS), and gross tumor volume (GTV) of the patients were 63 years (range, 46-87 years), 80% (range, 50-100%), and 46 ml (range, 5-250 ml), resp...
2017: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/28791389/abnormal-expression-of-hax%C3%A2-1-is-associated-with-cellular-proliferation-and-migration-in-human-hypopharyngeal-squamous-cell-carcinoma
#10
Hao Wu, Jianqiu Chen, Qiang Wang, Yong Yin, Peng Da, Huijun Le, Zhenxin Zhang, Xiaoxia Qiu
HCLS1‑associated protein X‑1 (HAX‑1) is highly expressed or overexpressed in various types of human tumor, and its overexpression is associated with cancer metastasis and cellular proliferation. However, the precise molecular mechanism involved in HAX‑1‑associated proliferation and metastasis in hypopharyngeal carcinoma is unknown. The present study aimed to investigate the role of HAX‑1 in the metastasis and proliferation of hypopharyngeal carcinoma. Reverse transcription‑quantitative polymerase chain reaction analysis and western blotting indicated that HAX‑1 was overexpressed in hypopharyngeal carcinoma specimens...
October 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28790260/-iii-non-surgical-treatment-strategy-for-locally-advanced-laryngeal-and-hypopharyngeal-cancer
#11
Naomi Kiyota
No abstract text is available yet for this article.
July 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28790257/-head-and-neck-tumor-larynx-preservation-in-locally-advanced-laryngeal-and-hypopharyngeal-cancer
#12
Hidenori Inohara
No abstract text is available yet for this article.
July 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28758200/endoscopic-screening-for-synchronous-esophageal-neoplasia-among-patients-with-incident-head-and-neck-cancer-prevalence-risk-factors-and-outcomes
#13
Yao-Kuang Wang, Yun-Shiuan Chuang, Tzung-Shiun Wu, Ka-Wo Lee, Che-Wei Wu, Hsiang-Chen Wang, Chie-Tong Kuo, Chien-Hung Lee, Wen-Rei Kuo, Chung-Ho Chen, Deng-Chyang Wu, I-Chen Wu
Esophageal squamous-cell neoplasia (ESCN) is a common second primary neoplasia found in patients with head-and-neck squamous-cell carcinoma (HNSCC). This study sought to identify the risk factors for synchronous ESCN and how they influence survival in HNSCC patient. Eight hundred and fifteen incident HNSCC patients were prospectively recruited for endoscopy screening for ESCN using white-light imaging, narrow-band imaging, Lugol chromoendoscopy, and pathological confirmation. Associated lifestyle and clinicopathological data were collected...
July 30, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28739753/application-of-ultrasound-guided-core-needle-biopsy-in-the-diagnosis-of-t3-or-t4-stage-laryngeal-and-hypopharyngeal-cancer
#14
Yunqiang Wang, Dajian Li, Ruihua Liu, Chuanliang Jia, Aihua Jiang, Yayun Lv, Shufen Xu, Hua Zhang, Xiaoli Cao, Xicheng Song
AIM: To study the value of ultrasound-guided core needle biopsy (CNB) in the diagnosis of T3 or T4 stage laryngeal and hypopharyngeal cancer, which is difficult by routine methods. PATIENTS AND METHODS: Nineteen cases of T3 or T4 stage laryngeal or hypopharyngeal carcinoma with abnormal pharyngeal sensitivity, severe dyspnea, submucous cancer recurrence, cardiovascular and pulmonary dysfunction were reviewed retrospectively from October 2012 to October 2014 in the Yuhuangding Hospital of Qingdao University...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28738894/occupational-exposure-to-chlorinated-solvents-and-risk-of-head-and-neck-cancer-in-men-a-population-based-case-control-study-in-france
#15
Christine Barul, Aurore Fayossé, Matthieu Carton, Corinne Pilorget, Anne-Sophie Woronoff, Isabelle Stücker, Danièle Luce
BACKGROUND: Few epidemiological studies have investigated the link between occupational exposure to solvents and head and neck cancer risk, and available findings are sparse and inconsistent. The objective of this study was to examine the association between occupational exposure to chlorinated solvents and head and neck cancer risk. METHODS: We analyzed data from 4637 men (1857 cases and 2780 controls) included in a population-based case-control study, ICARE (France)...
July 24, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/28736943/risk-factors-for-wound-complications-in-head-and-neck-reconstruction-773-free-jejunal-reconstruction-procedures-after-total-pharyngolaryngoesophagectomy
#16
Narushi Sugiyama, Soshi Takao, Etsuji Suzuki, Yoshihiro Kimata
BACKGROUND: Most studies that examined risk factors for wound complications after head and neck reconstruction analyzed various complications collectively. Moreover, they included a wide variety of resection areas and reconstruction materials. To overcome these limitations, both the resection area and reconstruction method were constrained in the present study. METHODS: Patients who underwent free jejunal graft reconstruction after pharyngolaryngoesophagectomy for hypopharyngeal cancer were enrolled...
October 2017: Head & Neck
https://www.readbyqxmd.com/read/28731497/the-effect-of-frailty-on-short-term-outcomes-after-head-and-neck-cancer-surgery
#17
Carrie L Nieman, Karen T Pitman, Anthony P Tufaro, David W Eisele, Kevin D Frick, Christine G Gourin
OBJECTIVE: To determine the relationship between frailty and comorbidity, in-hospital mortality, postoperative complications, length of hospital stay (LOS), and costs in head and neck cancer (HNCA) surgery. STUDY DESIGN: Cross-sectional analysis. METHODS: Discharge data from the Nationwide Inpatient Sample for 159,301 patients who underwent ablative surgery for a malignant oral cavity, laryngeal, hypopharyngeal, or oropharyngeal neoplasm in 2001 to 2010 was analyzed using cross-tabulations and multivariate regression modeling...
July 21, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28693209/frequent-aberrant-p53-and-fhit-expression-in-endoscopically-resected-superficial-hypopharyngeal-cancer-and-esophageal-cancer
#18
Sohei Yamamoto, Kazuo Yashima, Soichiro Kawata, Kohei Hosoda, Akihiro Tamoto, Yuichiro Ikebuchi, Kazuya Matsumoto, Koichiro Kawaguchi, Kenichi Harada, Yoshikazu Murawaki, Hajime Isomoto
In the last decade, the incidence rate of detection rate of superficial head, neck and esophageal squamous cell carcinomas has increased with the development of endoscopic imaging techniques. These cancers are thought to arise independently subsequent to tissue exposure to a common carcinogen e.g. alcohol or tobacco. This phenomenon has been termed field cancerization. To determine the molecular background of the development of hypopharyngeal squamous cell carcinomas (HPSCCs) and double esophageal squamous cell carcinomas (DESCCs), the present study immunohistochemically assessed tumor-related protein expression [p53, Fhit (fragile histidine triad), E-cadherin and activation-induced cytidine deaminase (AID)], and subsequently determined the correlation between protein expression and clinicopathological data...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28691358/survival-benefit-of-surgical-approach-for-advanced-oropharyngeal-and-hypopharyngeal-cancer-a-retrospective-analysis
#19
Chih-Tao Cheng, Ching-Yuan Lin, Skye Hung-Chun Cheng, Yi-Ping Lin, Lay-Chin Lim, Nicolas Pennarun, Zhen-Ying Liu, Shyuang-Der Terng
BACKGROUND: Head and neck cancer is increasingly being managed through nonsurgical approaches. Evidence comes from studies that have mainly examined patients with laryngeal cancer. Few studies, with limited sample size, have focused on the comparative outcomes of surgical and nonsurgical approaches in patients with advanced oropharyngeal or hypopharyngeal cancer. METHODS: Using a national cancer database, we identified 1603 and 1512 patients with clinical stage III/IVA oropharyngeal and hypopharyngeal cancer, respectively, treated between 2004 and 2009...
July 10, 2017: Head & Neck
https://www.readbyqxmd.com/read/28688681/the-long-term-oncological-and-functional-outcomes-of-transoral-robotic-surgery-in-patients-with-hypopharyngeal-cancer
#20
Young Min Park, Chan Min Jung, Dongchul Cha, Se-Heon Kim
OBJECTIVE: We conducted a prospective clinical trial of transoral robotic surgery in patients with hypopharyngeal cancer and herein report the long-term oncological and functional outcomes. MATERIALS AND METHODS: Between April 2008 and March 2014, 45 patients diagnosed with hypopharyngeal cancer participated in this prospective study. RESULTS: All patients were male with a mean age of 66.7years. The median follow-up period was 60months. Patients were classified using the staging system of the American Joint Commission on Cancer, as follows: Stage I, 7...
August 2017: Oral Oncology
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