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Hypopharyngeal cancer

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https://www.readbyqxmd.com/read/28303058/-18f-fluorodeoxyglucose-uptake-by-positron-emission-tomography-predicts-outcomes-for-oropharyngeal-and-hypopharyngeal-cancer-treated-with-definitive-radiotherapy
#1
Takeaki Ishihara, Kazuhiro Kitajima, Yuko Suenaga, Yasuo Ejima, Hirokazu Komatsu, Naoki Otsuki, Ken-Ichi Nibu, Naomi Kiyota, Satoru Takahashi, Ryohei Sasaki
This study evaluated the prognostic significance of the maximum standardized uptake value of the primary site (pSUVmax) in 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) scans of patients with oropharyngeal or hypopharyngeal cancer who were treated using definitive radiotherapy. The study included 86 patients who were primarily treated with radiotherapy for oropharyngeal or hypopharyngeal cancer. Sixty-nine patients underwent concurrent chemotherapy. The associations between pre-treatment pSUVmax and treatment outcomes were evaluated...
February 2017: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/28301066/effect-of-daily-fraction-size-on-laryngoesophageal-dysfunction-after-chemoradiation-for-squamous-cell-carcinomas-of-the-larynx-and-hypopharynx
#2
Allen M Chen, Sophia Hsu, Jessica Meshman, Robert Chin, Philip Beron, Elliot Abemayor, Maie St John
BACKGROUND: The purpose of this study was to determine the effect of fraction size on laryngoesophageal dysfunction among patients treated by chemoradiotherapy for laryngeal and hypopharyngeal cancer. METHODS: Forty patients underwent chemoradiotherapy for stage III/IV squamous cell carcinomas of the larynx and hypopharynx. Median radiation dose was 70 Gy (range, 69.3-70.4 Gy) with daily fractionation ranging from 2 Gy to 2.2 Gy. RESULTS: When comparing 2 Gy versus >2 Gy daily fractionation, there was no difference in 2-year overall survival (71% vs 72%; p = ...
March 16, 2017: Head & Neck
https://www.readbyqxmd.com/read/28276321/downregulation-of-calcium-binding-protein-s100a9-inhibits-hypopharyngeal-cancer-cell-proliferation-and-invasion-ability-through-inactivation-of-nf%C3%AE%C2%BAb-signaling
#3
Ping Wu, Huatao Quan, Jing Kang, Jian He, Shi Luo, Chubo Xie, Jing Xu, Yaoyun Tang, Suping Zhao
Hypopharyngeal cancer (HPC) frequently present at an advanced stage, and display early submucosal spread, resulting inpoor prognosis, among the worst of all head and neck subsites. Detection of HPC at an earlier stage would be beneficial to patients. In this study, we used Differential in-gel electrophoresis (DIGE) and two-dimensional polyacrylamide gel electrophoresis (2-DE) proteomics analysis to indentify the potential biomarkers for HPC. Among the differential proteins identified, calcium binding protein S100A9 was overexpressed in HPC tissues compared with normal adjacent tissues, and S100A9 expression in metastatic tissues and advanced tumor tissues was higher than in non-metastatic tissues and early tumor tissues, respectively...
March 8, 2017: Oncology Research
https://www.readbyqxmd.com/read/28259450/modality-specific-target-definition-for-laryngeal-and-hypopharyngeal-cancer-on-fdg-pet-ct-and-mri
#4
Hans Ligtenberg, Elise Anne Jager, Joana Caldas-Magalhaes, Tim Schakel, Frank A Pameijer, Nicolien Kasperts, Stefan M Willems, Chris H J Terhaard, Cornelis P J Raaijmakers, Marielle E P Philippens
BACKGROUND AND PURPOSE: The goal of this study was to improve target definition by deriving modality-specific margins for clinical target volumes (CTV) for laryngeal and hypopharyngeal cancer on CT, MRI and 18-FDG-PET. MATERIAL AND METHODS: Twenty-five patients with T3/T4 laryngeal/hypopharyngeal cancer underwent CT, MRI and 18-FDG-PET scans before laryngectomy. HE-sections were obtained from the surgical specimen and tumor was delineated (tumorHE). The GTVs on CT and MRI were delineated in consensus...
March 1, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28239587/manoeuvres-to-improve-endoscopic-visualization-of-hypopharynx
#5
Pooja Thakur, V K Poorey
The more progress achieved in endoscopy, the more superficial cancers in head and neck region have been diagnosed. There are, however, some areas difficult to observe, particularly the hypopharynx, due to closure of this space. Examination of hypopharynx form an essential part of head and neck examination especially in the suspected malignancies as well as in the cases with unknown primary. As the flexible fiber-optic nasopharyngolaryngoscopy forms an essential part of examination of hypopharynx, the present study aims to evaluate the effectiveness of various manoeuvres devised to aid in better visualization of the hypopharynx...
March 2017: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/28225552/potential-clinical-significance-of-perioperative-levels-of-mrna-in-plasma-from-patients-with-cancer-of-the-larynx-or-hypopharynx
#6
Dolores C García-Olmo, J Diego Contreras, María G Picazo, Jesús López-Torres, Damián García-Olmo
BACKGROUND: The use of plasma as a "liquid biopsy" has gained increasing attention. The purpose of the present study was to evaluate the diagnostic and prognostic utility of the perioperative detection and quantitation of mRNAs encoding human telomerase reverse transcriptase (hTERT) and glyceraldehyde 3-phosphate dehydrogenase (GAPDH) in plasma from patients with cancer of the larynx or hypopharynx. METHODS: We recruited 47 patients with laryngeal cancer and 2 patients with hypopharyngeal cancer, plus 27 healthy subjects...
April 2017: Head & Neck
https://www.readbyqxmd.com/read/28195888/a-novel-application-of-double-paddle-peroneal-chimeric-flap-as-external-sentinel-monitor-in-hypopharyngeal-reconstruction
#7
Jung-Hua Hsueh, Yu-Hsuan Hsieh, Ying-Sheng Lin, Yaoh-Shiang Lin, Kuo-Chung Yang, Wen-Chung Liu
OBJECTIVES: Monitoring the viability of buried free flaps in hypopharyngeal reconstruction is difficult. Various methods have been proposed to monitor these buried flaps, but limitations remain. METHOD: We present a method of using double-paddle chimeric peroneal flaps that permanently externalizes a flap skin paddle as a monitoring paddle in hypopharyngeal reconstructions. This study was performed in a medical center in southern Taiwan; between 2013 and 2015, 10 patients underwent double-paddle chimeric peroneal flap reconstruction in advanced stages of hypopharyngeal cancer...
March 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28190450/transoral-laser-microsurgery-as-standard-approach-to-hypopharyngeal-cancer-survival-analysis-in-a-hospital-based-population
#8
Eduardo Breda, Raquel Catarino, Eurico Monteiro
OBJECTIVE: Cancer of the hypopharynx remains one of the most challenging chapters in head and neck oncology. The objective of this study is to ascertain the relevance of a transoral laser approach as a valid functional option for treatment of cancer of the hypopharynx in Portugal, and additionally, to confirm the reproducibility of survival and functional outcomes described in other reference centers. SUBJECTS AND METHODS: The outcomes of 37 out of 60 patients presenting hypopharyngeal carcinoma primarily treated by TLM (transoral laser microsurgery) and neck dissection and or adjuvant treatment when needed, with curative intention in tertiary referral center, were retrospectively evaluated and compared with published results...
February 10, 2017: Acta Otorrinolaringológica Española
https://www.readbyqxmd.com/read/28182816/a-13-year-single-institutional-experience-with-definitive-radiotherapy-in-hypopharyngeal-cancer
#9
LETTER
Kiattisa Sommat, Sook Kwin Yong, Kam Weng Fong, Terence Wk Tan, Joseph Ts Wee, Yoke Lim Soong
No abstract text is available yet for this article.
January 2017: Annals of the Academy of Medicine, Singapore
https://www.readbyqxmd.com/read/28179356/clinical-outcomes-of-hypopharyngeal-cancer-receiving-definitive-radiotherapy-with-concurrent-chemotherapy
#10
Masakuni Sakaguchi, Toshiya Maebayashi, Takuya Aizawa, Naoya Ishibashi, Tsutomu Saito
AIM: To evaluate clinical outcomes of concurrent chemoradiotherapy (CCRT) in patients with hypopharyngeal cancer (HPC). PATIENTS AND METHODS: This retrospective study included 80 patients (75 males) aged 48 to 78 years (median=66 years) with a histological diagnosis of HPC. The 5-fluorouracil and cisplatin (FP) regimen was used until 2007 and then switched to the docetaxel, cisplatin, and 5-fluorouracil (TPF) regimen. Radiotherapy was administered to a total dose of 60 to 72 Gy (median=66 Gy)...
2017: Anticancer Research
https://www.readbyqxmd.com/read/28130622/lymph-node-ratio-predicts-recurrence-and-survival-for-patients-with-resectable-stage-4-hypopharyngeal-cancer
#11
Wu-Chia Lo, Chen-Tu Wu, Cheng-Ping Wang, Tsung-Lin Yang, Pei-Jen Lou, Jeng-Yuh Ko, Yih-Leong Chang
BACKGROUND: This study aimed to investigate the clinicopathologic prognostic predictors of stage 4 hypopharyngeal cancer and to extend the traditional tumor-node-metastasis classification system to advance its predictive ability. METHODS: The study enrolled 120 patients with pathologically stage 4 hypopharyngeal cancer treated with pharyngolaryngectomy and neck dissection between 2001 and 2007. RESULTS: The study showed a 5-year overall survival (OS) of 44...
January 27, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28110860/results-of-total-laryngectomy-as-treatment-for-locally-advanced-hypopharyngeal-cancer
#12
Patricia García-Cabo Herrero, Laura Fernández-Vañes, Fernando López Álvarez, César Álvarez Marcos, José Luis Llorente, Juan Pablo Rodrigo
INTRODUCTION AND OBJECTIVES: Total laryngectomy (TL), with eventual postoperative radiotherapy, has proven to be effective in treating cases of locally advanced hypopharyngeal cancer. The aim of this study was to analyse the oncological outcomes of this procedure in patients with hypopharyngeal cancer classified T3 and T4. METHODS: We studied 59 patients (33 T3 and 26 T4a) with primary squamous cell carcinoma of the hypopharynx treated with TL from 1998 to 2012...
January 19, 2017: Acta Otorrinolaringológica Española
https://www.readbyqxmd.com/read/28107467/correction-routine-endoscopy-for-esophageal-cancer-is-suggestive-for-patients-with-oral-oropharyngeal-and-hypopharyngeal-cancer
#13
Shih-Han Hung, Ming-Chieh Tsai, Tsai-Ching Liu, Herng-Ching Lin, Shiu-Dong Chung
[This corrects the article DOI: 10.1371/journal.pone.0072097.].
2017: PloS One
https://www.readbyqxmd.com/read/28105346/human-papillomavirus-is-a-favourable-prognostic-factor-in-cancer-of-unknown-primary-in-the-head-and-neck-region-and-in-hypopharyngeal-cancer
#14
Lars Sivars, Cinzia Bersani, Nathalie Grün, Torbjörn Ramqvist, Eva Munck-Wikland, Christian Von Buchwald, Tina Dalianis
Human papillomavirus (HPV), in addition to smoking and alcohol, is a cause of oropharyngeal squamous cell carcinoma (OPSCC), particularly of the tonsils and base of the tongue (TSCC and BOTSCC, respectively). Moreover, HPV-positive TSCC and BOTSCC are associated with a better outcome compared with their HPV-negative counterparts (80 vs. 40% 3-year disease-free survival rate, respectively) and their incidence has increased in several countries. Recently, accumulating evidence of HPV in a considerable proportion of cancers of unknown primary (CUP) in the head and neck region and in a small proportion of hypopharyngeal SCCs has been reported...
December 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28087965/hypopharyngeal-cancer-masquerading-as-a-thyroid-mass
#15
P S Heng, M Irfan
Hypopharyngeal cancer (HPC) is generally a rare head and neck malignancy. There are differing clinical presentations depending on the subsite location of primary tumour. Advanced HPC will have neck node metastasis particularly upper jugulodigastric nodes. We report a patient with postcricoid tumour who presented with anterior huge neck swelling mimic thyroid mass. The patient first presented to the General Surgical Unit for management of presumed thyroid lesion. She was diagnosed post-cricoid squamous cell carcinoma when further assessed by otorhinolaryngologist...
December 2016: Medical Journal of Malaysia
https://www.readbyqxmd.com/read/28062933/single-cycle-induction-chemotherapy-for-resectable-advanced-hypopharyngeal-cancer
#16
Torahiko Nakashima, Ryuji Yasumatsu, Kaori Asai, Hideoki Uryu, Ryunosuke Kogo, Takashi Nakagawa
BACKGROUND: The role of induction chemotherapy (IC) in the treatment of resectable advanced head and neck squamous cell carcinoma has not been elucidated, and the most effective IC regimen for chemoselection is still unknown. At our institute we have not used the triple combination of docetaxel, cisplatin, fluorouracil (TPF) for chemoselection, but rather the double combination of docetaxel + cisplatin (TP). The aim of this study is to report the outcome of patients with advanced hypopharyngeal cancer treated by single cycle of IC with TP followed by chemoradiation (CRT) or surgery...
January 6, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28033526/induction-chemotherapy%C3%A2-followed-by-radiotherapy-for-larynx-preservation-in-advanced-laryngeal-and-hypopharyngeal-cancer-outcome-prediction-after-one-cycle-induction-chemotherapy-by-a-score-based-on-clinical-evaluation-computed-tomography-based-volumetry%C3%A2-and
#17
Gunnar Wichmann, Anne Krüger, Andreas Boehm, Marlen Kolb, Mathias Hofer, Milos Fischer, Stefan Müller, Sandra Purz, Patrick Stumpp, Osama Sabri, Andreas Dietz, Regine Kluge
BACKGROUND: Long-term laryngectomy-free (LFS), tumour-specific (TSS) and overall survival (OS) is achieved by non-surgical larynx preservation (LP) only in a proportion of patients with locally advanced laryngeal or hypopharyngeal cancer. A score facilitating decision-making after 1 cycle induction chemotherapy (IC-1) may improve LFS and TSS. METHODS: Early response to IC-1 with TPF ± cetuximab was assessed in 52 patients using endoscopic tumour staging for selecting total laryngectomy for non-responders with endoscopic tumour surface shrinkage <30% versus induction chemotherapy plus radiotherapy (IC + RT) for responders...
December 26, 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/28030898/early-hypopharyngeal-cancer-treated-with-different-therapeutic-approaches-a-single-institution-cohort-analysis
#18
Nalee Kim, Jeongshim Lee, Kyung Hwan Kim, Jong Won Park, Chang Geol Lee, Ki Chang Keum
PURPOSE: Early hypopharyngeal squamous cell carcinoma (HPSCC) is a rarely diagnosed disease, for which the optimal treatment has not been defined yet. We assessed patterns of failure and outcomes in early HPSCC treated with various therapeutic approaches to identify its optimal treatment. MATERIALS AND METHODS: Thirty-six patients with stage I (n = 10) and II (n = 26) treated between January 1992 and March 2014 were reviewed. Patients received definitive radiotherapy (RT) (R group, n = 10), surgery only (S group, n = 19), or postoperative RT (PORT group, n = 7)...
December 2016: Radiation Oncology Journal
https://www.readbyqxmd.com/read/28008394/does-opium-dependency-affect-the-pattern-of-involvement-in-laryngeal-cancer
#19
Peyman Dabirmoghaddam, Ali Karimian Taheri, Hosein Ghazavi, Shaghayegh Ebrahimnejad, Zahra Karimian
INTRODUCTION: Laryngeal cancer is the second most common cancer involving the respiratory tract, second only to lung cancer. Previous studies have shown opium dependency to be a possible risk factor for laryngeal cancer. Opium consumption is a major problem in some parts of the world. The aim of this study was to investigate the effect of opium consumption on the pattern of involvement in laryngeal cancer. METHODS AND MATERIALS: In this analytical cross-sectional study, 44 patients diagnosed with laryngeal cancer (41 male and three female) were studied...
November 2016: Iranian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28001302/impact-of-concomitant-chemoradiation-on-survival-for-patients-with-t1-2n1-head-and-neck-cancer
#20
Zachary S Zumsteg, Sungjin Kim, John M David, Emi J Yoshida, Mourad Tighiouart, Stephen L Shiao, Kevin Scher, Alain Mita, Eric J Sherman, Nancy Y Lee, Allen S Ho
BACKGROUND: Single-modality radiotherapy is considered a standard-of-care option for certain stage III, T1-2N1 head and neck squamous cell carcinomas (HNSCCs). The role of concomitant chemoradiation is not well established because there have been no studies comparing chemoradiation with radiation alone in this population. METHODS: This study analyzed patients in the National Cancer Data Base with cT1-2N1M0 invasive squamous cell carcinomas of the oropharynx, larynx, and hypopharynx who were diagnosed between 2004 and 2012 and were undergoing definitive radiation...
December 21, 2016: Cancer
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