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Hypopharyngeal cancer

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https://www.readbyqxmd.com/read/28195888/a-novel-application-of-double-paddle-peroneal-chimeric-flap-as-external-sentinel-monitor-in-hypopharyngeal-reconstruction
#1
Jung-Hua Hsueh, Yu-Hsuan Hsieh, Ying-Sheng Lin, Yaoh-Shiang Lin, Kuo-Chung Yang, Wen-Chung Liu
OBJECTIVES: Monitoring the viability of buried free flaps in hypopharyngeal reconstruction is difficult. Various methods have been proposed to monitor these buried flaps, but limitations remain. METHOD: We present a method of using double-paddle chimeric peroneal flaps that permanently externalizes a flap skin paddle as a monitoring paddle in hypopharyngeal reconstructions. This study was performed in a medical center in southern Taiwan; between 2013 and 2015, 10 patients underwent double-paddle chimeric peroneal flap reconstruction in advanced stages of hypopharyngeal cancer...
February 14, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28190450/transoral-laser-microsurgery-as-standard-approach-to-hypopharyngeal-cancer-survival-analysis-in-a-hospital-based-population
#2
Eduardo Breda, Raquel Catarino, Eurico Monteiro
OBJECTIVE: Cancer of the hypopharynx remains one of the most challenging chapters in head and neck oncology. The objective of this study is to ascertain the relevance of a transoral laser approach as a valid functional option for treatment of cancer of the hypopharynx in Portugal, and additionally, to confirm the reproducibility of survival and functional outcomes described in other reference centers. SUBJECTS AND METHODS: The outcomes of 37 out of 60 patients presenting hypopharyngeal carcinoma primarily treated by TLM (transoral laser microsurgery) and neck dissection and or adjuvant treatment when needed, with curative intention in tertiary referral center, were retrospectively evaluated and compared with published results...
February 10, 2017: Acta Otorrinolaringológica Española
https://www.readbyqxmd.com/read/28182816/a-13-year-single-institutional-experience-with-definitive-radiotherapy-in-hypopharyngeal-cancer
#3
Kiattisa Sommat, Sook Kwin Yong, Kam Weng Fong, Terence Wk Tan, Joseph Ts Wee, Yoke Lim Soong
No abstract text is available yet for this article.
January 2017: Annals of the Academy of Medicine, Singapore
https://www.readbyqxmd.com/read/28179356/clinical-outcomes-of-hypopharyngeal-cancer-receiving-definitive-radiotherapy-with-concurrent-chemotherapy
#4
Masakuni Sakaguchi, Toshiya Maebayashi, Takuya Aizawa, Naoya Ishibashi, Tsutomu Saito
AIM: To evaluate clinical outcomes of concurrent chemoradiotherapy (CCRT) in patients with hypopharyngeal cancer (HPC). PATIENTS AND METHODS: This retrospective study included 80 patients (75 males) aged 48 to 78 years (median=66 years) with a histological diagnosis of HPC. The 5-fluorouracil and cisplatin (FP) regimen was used until 2007 and then switched to the docetaxel, cisplatin, and 5-fluorouracil (TPF) regimen. Radiotherapy was administered to a total dose of 60 to 72 Gy (median=66 Gy)...
2017: Anticancer Research
https://www.readbyqxmd.com/read/28130622/lymph-node-ratio-predicts-recurrence-and-survival-for-patients-with-resectable-stage-4-hypopharyngeal-cancer
#5
Wu-Chia Lo, Chen-Tu Wu, Cheng-Ping Wang, Tsung-Lin Yang, Pei-Jen Lou, Jeng-Yuh Ko, Yih-Leong Chang
BACKGROUND: This study aimed to investigate the clinicopathologic prognostic predictors of stage 4 hypopharyngeal cancer and to extend the traditional tumor-node-metastasis classification system to advance its predictive ability. METHODS: The study enrolled 120 patients with pathologically stage 4 hypopharyngeal cancer treated with pharyngolaryngectomy and neck dissection between 2001 and 2007. RESULTS: The study showed a 5-year overall survival (OS) of 44...
January 27, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28110860/results-of-total-laryngectomy-as-treatment-for-locally-advanced-hypopharyngeal-cancer
#6
Patricia García-Cabo Herrero, Laura Fernández-Vañes, Fernando López Álvarez, César Álvarez Marcos, José Luis Llorente, Juan Pablo Rodrigo
INTRODUCTION AND OBJECTIVES: Total laryngectomy (TL), with eventual postoperative radiotherapy, has proven to be effective in treating cases of locally advanced hypopharyngeal cancer. The aim of this study was to analyse the oncological outcomes of this procedure in patients with hypopharyngeal cancer classified T3 and T4. METHODS: We studied 59 patients (33 T3 and 26 T4a) with primary squamous cell carcinoma of the hypopharynx treated with TL from 1998 to 2012...
January 19, 2017: Acta Otorrinolaringológica Española
https://www.readbyqxmd.com/read/28107467/correction-routine-endoscopy-for-esophageal-cancer-is-suggestive-for-patients-with-oral-oropharyngeal-and-hypopharyngeal-cancer
#7
Shih-Han Hung, Ming-Chieh Tsai, Tsai-Ching Liu, Herng-Ching Lin, Shiu-Dong Chung
[This corrects the article DOI: 10.1371/journal.pone.0072097.].
2017: PloS One
https://www.readbyqxmd.com/read/28105346/human-papillomavirus-is-a-favourable-prognostic-factor-in-cancer-of-unknown-primary-in-the-head-and-neck-region-and-in-hypopharyngeal-cancer
#8
Lars Sivars, Cinzia Bersani, Nathalie Grün, Torbjörn Ramqvist, Eva Munck-Wikland, Christian Von Buchwald, Tina Dalianis
Human papillomavirus (HPV), in addition to smoking and alcohol, is a cause of oropharyngeal squamous cell carcinoma (OPSCC), particularly of the tonsils and base of the tongue (TSCC and BOTSCC, respectively). Moreover, HPV-positive TSCC and BOTSCC are associated with a better outcome compared with their HPV-negative counterparts (80 vs. 40% 3-year disease-free survival rate, respectively) and their incidence has increased in several countries. Recently, accumulating evidence of HPV in a considerable proportion of cancers of unknown primary (CUP) in the head and neck region and in a small proportion of hypopharyngeal SCCs has been reported...
December 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28087965/hypopharyngeal-cancer-masquerading-as-a-thyroid-mass
#9
P S Heng, M Irfan
Hypopharyngeal cancer (HPC) is generally a rare head and neck malignancy. There are differing clinical presentations depending on the subsite location of primary tumour. Advanced HPC will have neck node metastasis particularly upper jugulodigastric nodes. We report a patient with postcricoid tumour who presented with anterior huge neck swelling mimic thyroid mass. The patient first presented to the General Surgical Unit for management of presumed thyroid lesion. She was diagnosed post-cricoid squamous cell carcinoma when further assessed by otorhinolaryngologist...
December 2016: Medical Journal of Malaysia
https://www.readbyqxmd.com/read/28062933/single-cycle-induction-chemotherapy-for-resectable-advanced-hypopharyngeal-cancer
#10
Torahiko Nakashima, Ryuji Yasumatsu, Kaori Asai, Hideoki Uryu, Ryunosuke Kogo, Takashi Nakagawa
BACKGROUND: The role of induction chemotherapy (IC) in the treatment of resectable advanced head and neck squamous cell carcinoma has not been elucidated, and the most effective IC regimen for chemoselection is still unknown. At our institute we have not used the triple combination of docetaxel, cisplatin, fluorouracil (TPF) for chemoselection, but rather the double combination of docetaxel + cisplatin (TP). The aim of this study is to report the outcome of patients with advanced hypopharyngeal cancer treated by single cycle of IC with TP followed by chemoradiation (CRT) or surgery...
January 6, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28033526/induction-chemotherapy%C3%A2-followed-by-radiotherapy-for-larynx-preservation-in-advanced-laryngeal-and-hypopharyngeal-cancer-outcome-prediction-after-one-cycle-induction-chemotherapy-by-a-score-based-on-clinical-evaluation-computed-tomography-based-volumetry%C3%A2-and
#11
Gunnar Wichmann, Anne Krüger, Andreas Boehm, Marlen Kolb, Mathias Hofer, Milos Fischer, Stefan Müller, Sandra Purz, Patrick Stumpp, Osama Sabri, Andreas Dietz, Regine Kluge
BACKGROUND: Long-term laryngectomy-free (LFS), tumour-specific (TSS) and overall survival (OS) is achieved by non-surgical larynx preservation (LP) only in a proportion of patients with locally advanced laryngeal or hypopharyngeal cancer. A score facilitating decision-making after 1 cycle induction chemotherapy (IC-1) may improve LFS and TSS. METHODS: Early response to IC-1 with TPF ± cetuximab was assessed in 52 patients using endoscopic tumour staging for selecting total laryngectomy for non-responders with endoscopic tumour surface shrinkage <30% versus induction chemotherapy plus radiotherapy (IC + RT) for responders...
December 26, 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/28030898/early-hypopharyngeal-cancer-treated-with-different-therapeutic-approaches-a-single-institution-cohort-analysis
#12
Nalee Kim, Jeongshim Lee, Kyung Hwan Kim, Jong Won Park, Chang Geol Lee, Ki Chang Keum
PURPOSE: Early hypopharyngeal squamous cell carcinoma (HPSCC) is a rarely diagnosed disease, for which the optimal treatment has not been defined yet. We assessed patterns of failure and outcomes in early HPSCC treated with various therapeutic approaches to identify its optimal treatment. MATERIALS AND METHODS: Thirty-six patients with stage I (n = 10) and II (n = 26) treated between January 1992 and March 2014 were reviewed. Patients received definitive radiotherapy (RT) (R group, n = 10), surgery only (S group, n = 19), or postoperative RT (PORT group, n = 7)...
December 2016: Radiation Oncology Journal
https://www.readbyqxmd.com/read/28008394/does-opium-dependency-affect-the-pattern-of-involvement-in-laryngeal-cancer
#13
Peyman Dabirmoghaddam, Ali Karimian Taheri, Hosein Ghazavi, Shaghayegh Ebrahimnejad, Zahra Karimian
INTRODUCTION: Laryngeal cancer is the second most common cancer involving the respiratory tract, second only to lung cancer. Previous studies have shown opium dependency to be a possible risk factor for laryngeal cancer. Opium consumption is a major problem in some parts of the world. The aim of this study was to investigate the effect of opium consumption on the pattern of involvement in laryngeal cancer. METHODS AND MATERIALS: In this analytical cross-sectional study, 44 patients diagnosed with laryngeal cancer (41 male and three female) were studied...
November 2016: Iranian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28001302/impact-of-concomitant-chemoradiation-on-survival-for-patients-with-t1-2n1-head-and-neck-cancer
#14
Zachary S Zumsteg, Sungjin Kim, John M David, Emi J Yoshida, Mourad Tighiouart, Stephen L Shiao, Kevin Scher, Alain Mita, Eric J Sherman, Nancy Y Lee, Allen S Ho
BACKGROUND: Single-modality radiotherapy is considered a standard-of-care option for certain stage III, T1-2N1 head and neck squamous cell carcinomas (HNSCCs). The role of concomitant chemoradiation is not well established because there have been no studies comparing chemoradiation with radiation alone in this population. METHODS: This study analyzed patients in the National Cancer Data Base with cT1-2N1M0 invasive squamous cell carcinomas of the oropharynx, larynx, and hypopharynx who were diagnosed between 2004 and 2012 and were undergoing definitive radiation...
December 21, 2016: Cancer
https://www.readbyqxmd.com/read/27999896/correlation-of-pretreatment-18-f-fdg-pet-tumor-textural-features-with-gene-expression-in-pharyngeal-cancer-and-implications-for-radiotherapy-based-treatment-outcomes
#15
Shang-Wen Chen, Wei-Chih Shen, Ying-Chun Lin, Rui-Yun Chen, Te-Chun Hsieh, Kuo-Yang Yen, Chia-Hung Kao
PURPOSE: This study investigated the correlation of the matrix heterogeneity of tumors on (18)F-fluorodeoxyglucose positron emission tomography-computed tomography (PET-CT) with gene-expression profiling in patients with pharyngeal cancer and determined the prognostic factors for radiotherapy-based treatment outcomes. METHODS: We retrospectively reviewed the records of 57 patients with stage III-IV oropharyngeal or hypopharyngeal cancer who had completed definitive therapy...
December 20, 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27988198/primary-total-laryngectomy-and-pharyngolaryngectomy-in-t4-pharyngolaryngeal-cancers-oncologic-and-functional-results-and-prognostic-factors
#16
M Roux, O Dassonville, M Ettaiche, E Chamorey, G Poissonnet, A Bozec
OBJECTIVES: The aims of this study were to assess oncologic and functional outcome in primary total laryngectomy or pharyngolaryngectomy (TL/TL/TPL) for laryngeal or hypopharyngeal cancer with extra-laryngeal extension (T4) and to determine the predictive factors of these results. MATERIAL AND METHODS: A retrospective analysis was performed on the computerized medical records of all patients undergoing primary TL/TPL for T4 larynx or hypopharynx squamous cell carcinoma between 2000 and 2014 at our institution...
December 14, 2016: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/27976979/vocal-function-after-transoral-videolaryngoscopic-surgery-tovs-for-hypopharyngeal-and-supraglottic-cancer
#17
Shingo Tanaka, Masayuki Tomifuji, Koji Araki, Kosuke Uno, Yuya Tanaka, Daisuke Mizokami, Hiroshi Suzuki, Yoshihiro Miyagawa, Shinichi Taniai, Akihiro Shiotani
CONCLUSION: The resection of the medial and lateral pyriform sinus was associated with post-operative voice impairment after TOVS. Scar contracture around the cricoarytenoid joint lead to arytenoid fixation toward lateral position, and this wound healing process caused insufficient glottis closure. Although oncological and functional outcomes of TOVS was satisfactory, surgeons should mention the risk of post-operative voice impairment in pre-operative counseling. OBJECTIVES: Transoral surgery is a minimally invasive treatment option for hypopharyngeal and supraglottic cancer...
December 15, 2016: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/27922696/down-syndrome-critical-region-1-positively-correlates-with-angiogenesis-in-hypopharyngeal-cancer
#18
Chao Lv, Dayu Liu, Xiaona Wei
Hypopharyngeal carcinoma has one of the highest mortality rates of head and neck cancer, therefore, the identification of markers associated with the pathogenesis and development of hypopharyngeal cancer is critical. Down syndrome critical region 1 (DSCR1) is associated with carcinogenesis and tumor growth in several types of malignancy. Activation of the vascular endothelial growth factor (VEGF) signaling pathway upregulates DSCR1. The aims of the present study were to determine the expression levels of DSCR1 and VEGF‑C in hypopharyngeal cancer, and investigate the association between DSCR1 and angiogenesis in the disease...
January 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27919985/clinical-outcomes-of-definitive-and-postoperative-radiotherapy-for-stage-i-ivb-hypopharyngeal-cancer
#19
Katsuyuki Shirai, Jun-Ichi Saitoh, Atsushi Musha, Takanori Abe, Daijiro Kobayashi, Yosuke Takakusagi, Yukihiro Takaysu, Masato Shino, Minoru Toyoda, Katsumasa Takahashi, Kazuaki Chikamatsu, Tatsuya Ohno, Takashi Nakano
BACKGROUND: Hypopharyngeal cancer is relatively rare disease and continues to have a poor prognosis. This study analyzed the efficacy and safety of radiotherapy for stage I-IVB hypopharyngeal cancer. PATIENTS AND METHODS: Between 2000 and 2015, 72 patients were treated with definitive radiotherapy and 29 patients with stage IVA were treated with postoperative radiotherapy. RESULTS: With definitive radiotherapy, the 3-year locoregional control rates for stage I-II, III, IVA, and IVB disease were 89%, 74%, 51% and 0%, respectively...
2016: Anticancer Research
https://www.readbyqxmd.com/read/27916282/repair-of-complex-pharyngocutaneous-fistula-using-a-staged-temporoparietal-fascial-flap
#20
Nicholas B Abt, Priya Srikanth, Sidharth V Puram, Daniel G Deschler
INTRODUCTION: PCF is the most common major complication after salvage total laryngectomy (TL), especially for previously irradiated patients with laryngeal or hypopharyngeal cancer. METHODS/RESULTS: A 65-year-old woman presented with recurrent bilateral supraglottic SCC requiring salvage TL 5.5years after initial T1N0M0 epiglottic SCC resection. Her post-operative course was complicated by PCF development one month post-operatively and surgical fistula closure was delayed for adjuvant chemoradiotherapy...
November 25, 2016: American Journal of Otolaryngology
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