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Hypopharyngeal cancer

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https://www.readbyqxmd.com/read/28791389/abnormal-expression-of-hax%C3%A2-1-is-associated-with-cellular-proliferation-and-migration-in-human-hypopharyngeal-squamous-cell-carcinoma
#1
Hao Wu, Jianqiu Chen, Qiang Wang, Yong Yin, Peng Da, Huijun Le, Zhenxin Zhang, Xiaoxia Qiu
HCLS1‑associated protein X‑1 (HAX‑1) is highly expressed or overexpressed in various types of human tumor, and its overexpression is associated with cancer metastasis and cellular proliferation. However, the precise molecular mechanism involved in HAX‑1‑associated proliferation and metastasis in hypopharyngeal carcinoma is unknown. The present study aimed to investigate the role of HAX‑1 in the metastasis and proliferation of hypopharyngeal carcinoma. Reverse transcription‑quantitative polymerase chain reaction analysis and western blotting indicated that HAX‑1 was overexpressed in hypopharyngeal carcinoma specimens...
August 3, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28790260/-iii-non-surgical-treatment-strategy-for-locally-advanced-laryngeal-and-hypopharyngeal-cancer
#2
Naomi Kiyota
No abstract text is available yet for this article.
July 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28790257/-head-and-neck-tumor-larynx-preservation-in-locally-advanced-laryngeal-and-hypopharyngeal-cancer
#3
Hidenori Inohara
No abstract text is available yet for this article.
July 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28758200/endoscopic-screening-for-synchronous-esophageal-neoplasia-among-patients-with-incident-head-and-neck-cancer-prevalence-risk-factors-and-outcomes
#4
Yao-Kuang Wang, Yun-Shiuan Chuang, Tzung-Shiun Wu, Ka-Wo Lee, Che-Wei Wu, Hsiang-Chen Wang, Chie-Tong Kuo, Chien-Hung Lee, Wen-Rei Kuo, Chung-Ho Chen, Deng-Chyang Wu, I-Chen Wu
Esophageal squamous-cell neoplasia (ESCN) is a common second primary neoplasia found in patients with head-and-neck squamous-cell carcinoma (HNSCC). This study sought to identify the risk factors for synchronous ESCN and how they influence survival in HNSCC patient. 815 incident HNSCC patients were prospectively recruited for endoscopy screening for ESCN using white-light imaging, narrow-band imaging, Lugol chromoendoscopy, and pathological confirmation. Associated lifestyle and clinicopathological data were collected...
July 30, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28739753/application-of-ultrasound-guided-core-needle-biopsy-in-the-diagnosis-of-t3-or-t4-stage-laryngeal-and-hypopharyngeal-cancer
#5
Yunqiang Wang, Dajian Li, Ruihua Liu, Chuanliang Jia, Aihua Jiang, Yayun Lv, Shufen Xu, Hua Zhang, Xiaoli Cao, Xicheng Song
AIM: To study the value of ultrasound-guided core needle biopsy (CNB) in the diagnosis of T3 or T4 stage laryngeal and hypopharyngeal cancer, which is difficult by routine methods. PATIENTS AND METHODS: Nineteen cases of T3 or T4 stage laryngeal or hypopharyngeal carcinoma with abnormal pharyngeal sensitivity, severe dyspnea, submucous cancer recurrence, cardiovascular and pulmonary dysfunction were reviewed retrospectively from October 2012 to October 2014 in the Yuhuangding Hospital of Qingdao University...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28738894/occupational-exposure-to-chlorinated-solvents-and-risk-of-head-and-neck-cancer-in-men-a-population-based-case-control-study-in-france
#6
Christine Barul, Aurore Fayossé, Matthieu Carton, Corinne Pilorget, Anne-Sophie Woronoff, Isabelle Stücker, Danièle Luce
BACKGROUND: Few epidemiological studies have investigated the link between occupational exposure to solvents and head and neck cancer risk, and available findings are sparse and inconsistent. The objective of this study was to examine the association between occupational exposure to chlorinated solvents and head and neck cancer risk. METHODS: We analyzed data from 4637 men (1857 cases and 2780 controls) included in a population-based case-control study, ICARE (France)...
July 24, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/28736943/risk-factors-for-wound-complications-in-head-and-neck-reconstruction-773-free-jejunal-reconstruction-procedures-after-total-pharyngolaryngoesophagectomy
#7
Narushi Sugiyama, Soshi Takao, Etsuji Suzuki, Yoshihiro Kimata
BACKGROUND: Most studies that examined risk factors for wound complications after head and neck reconstruction analyzed various complications collectively. Moreover, they included a wide variety of resection areas and reconstruction materials. To overcome these limitations, both the resection area and reconstruction method were constrained in the present study. METHODS: Patients who underwent free jejunal graft reconstruction after pharyngolaryngoesophagectomy for hypopharyngeal cancer were enrolled...
July 24, 2017: Head & Neck
https://www.readbyqxmd.com/read/28731497/the-effect-of-frailty-on-short-term-outcomes-after-head-and-neck-cancer-surgery
#8
Carrie L Nieman, Karen T Pitman, Anthony P Tufaro, David W Eisele, Kevin D Frick, Christine G Gourin
OBJECTIVE: To determine the relationship between frailty and comorbidity, in-hospital mortality, postoperative complications, length of hospital stay (LOS), and costs in head and neck cancer (HNCA) surgery. STUDY DESIGN: Cross-sectional analysis. METHODS: Discharge data from the Nationwide Inpatient Sample for 159,301 patients who underwent ablative surgery for a malignant oral cavity, laryngeal, hypopharyngeal, or oropharyngeal neoplasm in 2001 to 2010 was analyzed using cross-tabulations and multivariate regression modeling...
July 21, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28693209/frequent-aberrant-p53-and-fhit-expression-in-endoscopically-resected-superficial-hypopharyngeal-cancer-and-esophageal-cancer
#9
Sohei Yamamoto, Kazuo Yashima, Soichiro Kawata, Kohei Hosoda, Akihiro Tamoto, Yuichiro Ikebuchi, Kazuya Matsumoto, Koichiro Kawaguchi, Kenichi Harada, Yoshikazu Murawaki, Hajime Isomoto
In the last decade, the incidence rate of detection rate of superficial head, neck and esophageal squamous cell carcinomas has increased with the development of endoscopic imaging techniques. These cancers are thought to arise independently subsequent to tissue exposure to a common carcinogen e.g. alcohol or tobacco. This phenomenon has been termed field cancerization. To determine the molecular background of the development of hypopharyngeal squamous cell carcinomas (HPSCCs) and double esophageal squamous cell carcinomas (DESCCs), the present study immunohistochemically assessed tumor-related protein expression [p53, Fhit (fragile histidine triad), E-cadherin and activation-induced cytidine deaminase (AID)], and subsequently determined the correlation between protein expression and clinicopathological data...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28691358/survival-benefit-of-surgical-approach-for-advanced-oropharyngeal-and-hypopharyngeal-cancer-a-retrospective-analysis
#10
Chih-Tao Cheng, Ching-Yuan Lin, Skye Hung-Chun Cheng, Yi-Ping Lin, Lay-Chin Lim, Nicolas Pennarun, Zhen-Ying Liu, Shyuang-Der Terng
BACKGROUND: Head and neck cancer is increasingly being managed through nonsurgical approaches. Evidence comes from studies that have mainly examined patients with laryngeal cancer. Few studies, with limited sample size, have focused on the comparative outcomes of surgical and nonsurgical approaches in patients with advanced oropharyngeal or hypopharyngeal cancer. METHODS: Using a national cancer database, we identified 1603 and 1512 patients with clinical stage III/IVA oropharyngeal and hypopharyngeal cancer, respectively, treated between 2004 and 2009...
July 10, 2017: Head & Neck
https://www.readbyqxmd.com/read/28688681/the-long-term-oncological-and-functional-outcomes-of-transoral-robotic-surgery-in-patients-with-hypopharyngeal-cancer
#11
Young Min Park, Chan Min Jung, Dongchul Cha, Se-Heon Kim
OBJECTIVE: We conducted a prospective clinical trial of transoral robotic surgery in patients with hypopharyngeal cancer and herein report the long-term oncological and functional outcomes. MATERIALS AND METHODS: Between April 2008 and March 2014, 45 patients diagnosed with hypopharyngeal cancer participated in this prospective study. RESULTS: All patients were male with a mean age of 66.7years. The median follow-up period was 60months. Patients were classified using the staging system of the American Joint Commission on Cancer, as follows: Stage I, 7...
August 2017: Oral Oncology
https://www.readbyqxmd.com/read/28688676/predictors-of-readmissions-after-head-and-neck-cancer-surgery-a-national-perspective
#12
Michelle M Chen, Ryan K Orosco, Jeremy P Harris, Julie B Porter, Eben L Rosenthal, Wendy Hara, Vasu Divi
OBJECTIVES: Surgical oncology patients have multiple comorbidities and are at high risk of readmission. Prior studies are limited in their ability to capture readmissions outside of the index hospital that performed the surgery. Our goal is to evaluate risk factors for readmission for head and neck cancer patients on a national scale. MATERIAL AND METHODS: A retrospective cohort study of head and neck cancer patients in the Nationwide Readmissions Database (2013)...
August 2017: Oral Oncology
https://www.readbyqxmd.com/read/28676068/correlation-between-delivered-radiation-doses-to-the-brainstem-or-vestibular-organ-and-nausea-vomiting-toxicity-in-patients-with-head-and-neck-cancers-an-observational-clinical-trial
#13
Kilian Schiller, Hanno Martin Specht, Bernhard Haller, Daniela Hallqvist, Michal Devecka, Aaron Becker von Rose, Stephanie Elisabeth Combs, Steffi Pigorsch
OBJECTIVE: Today intensity modulated radiation therapy (IMRT) can be considered the standard of care in patients with head and neck tumors. IMRT treatment plans are proven to reduce acute treatment related side effects by optimal sparing of organs at risk (OAR). At the same time, areas that were out of the former 3D fields now receive low radiation doses. Amongst those areas the brainstem (BS) and the vestibular system (VS) are known to be physiologically connected to nausea and vomiting (NV)...
July 4, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28674582/intramedullary-spinal-cord-metastasis-from-laryngeal-carcinoma-case-report-and-review-of-literature
#14
REVIEW
Mohamed Sahli, Bouchaib Hemmaoui, Fouad Benariba
Laryngeal cancer metastases are relatively rare and mainly affect the lung. The medullary localization remains exceptional. We report the case of a patient followed for operated laryngeal cancer and whose oncologic control revealed a medullary localization. A patient followed for squamous cell carcinoma of the larynx, treated in 2010 by a partial surgery whose endoscopic control at 5 years revealed the presence of right arytenoid edema without suspicious lesions, multiple biopsies were made and which returned negative...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28658124/diagnosis-and-management-of-head-and-neck-cancers-in-a-high-incidence-area-in-france-a-population-based-study
#15
Anne-Valerie N Guizard, Olivier J Dejardin, Ludivine C Launay, Simona Bara, Bénédicte M Lapôtre-Ledoux, Emmanuel B Babin, Guy D Launoy, Karine A Ligier
Head and neck cancers have a very poor prognosis and are common in France. They are subject to various recommendations for early detection and management, but there is no detailed data in the French general population to fuel the public health debate on it.A high-resolution population-based study about cancer management was conducted, using cancers registries in the north-west of France, on 1729 tumors diagnosed between 2008 and 2010.The tumors were diagnosed late (70.3% stage III-IV), mainly after the onset of symptoms (93...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28651556/clinical-outcomes-of-transoral-videolaryngoscopic-surgery-for-hypopharyngeal-and-supraglottic-cancer
#16
Yorihisa Imanishi, Hiroyuki Ozawa, Koji Sakamoto, Ryoichi Fujii, Seiji Shigetomi, Noboru Habu, Kuninori Otsuka, Yoichiro Sato, Yoshihiro Watanabe, Mariko Sekimizu, Fumihiro Ito, Toshiki Tomita, Kaoru Ogawa
BACKGROUND: Transoral videolaryngoscopic surgery (TOVS) was developed as a new distinct surgical procedure for hypopharyngeal cancer (HPC) and supraglottic cancer (SGC) staged at up to T3. However, long-term treatment outcomes of TOVS remain to be validated. METHODS: Under a straight broad intraluminal view provided by combined use of a distending laryngoscope and a videolaryngoscope, we performed en bloc tumor resection via direct bimanual handling of the ready-made straight-form surgical instruments and devices...
June 26, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28624863/matched-pair-analysis-of-patients-with-advanced-hypopharyngeal-cancer-surgery-versus-concomitant-chemoradiotherapy
#17
Shigemichi Iwae, Masato Fujii, Ryuichi Hayashi, Yasuhisa Hasegawa, Takashi Fujii, Kenji Okami, Akihiro Homma, Tetsuro Onitsuka, Takakuni Kato, Takenori Ogawa, Kyoichi Terao, Nobuya Monden, Naoki Otsuki, Hiroshi Nishino, Ichiro Ota, Yasushi Fujimoto, Kazuto Matsuura, Kazuyoshi Kawabata, Hidetoshi Matsui, Koichiro Yonezawa, Ken-Ichi Nibu
BACKGROUND: The aim of this study was to compare the therapeutic outcomes of total pharyngolaryngectomy with those of concomitant chemoradiotherapy in advanced hypopharyngeal cancer. METHODS: This is a retrospective multi-institutional study. The medical records of 979 patients with hypopharyngeal cancer, who were initially treated between 2006 and 2008, were reviewed. In this study, we matched a group of total pharyngolaryngectomy patients with a second group of chemoradiotherapy patients, according to age, gender, subsite, arytenoid fixation, cartilage invasion, and N classification, and analyzed overall survival, disease-specific survival, and locoregional control rates...
June 17, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28600823/can-the-ni-classification-of-vessels-predict-neoplasia-a-systematic-review-and-meta-analysis
#18
Camilla S Mehlum, Tine Rosenberg, Anne-Kirstine Dyrvig, Aagot Moeller Groentved, Thomas Kjaergaard, Christian Godballe
OBJECTIVES: The Ni classification of vascular change from 2011 is well documented for evaluating pharyngeal and laryngeal lesions, primarily focusing on cancer. In the planning of surgery it may be more relevant to differentiate neoplasia from non-neoplasia. We aimed to evaluate the ability of the Ni classification to predict laryngeal or hypopharyngeal neoplasia and to investigate if a changed cutoff value would support the recent European Laryngological Society (ELS) proposal of perpendicular vascular changes as indicative of neoplasia...
June 10, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28593937/basaloid-squamous-cell-carcinoma-of-the-head-and-neck-subclassification-into-basal-ductal-and-mixed-subtypes-based-on-comparison-of-clinico-pathologic-features-and-expression-of-p53-cyclin-d1-epidermal-growth-factor-receptor-p16-and-human-papillomavirus
#19
Kyung-Ja Cho, Se Un Jeong, Sung Bae Kim, Sang-Wook Lee, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim
BACKGROUND: Basaloid squamous cell carcinoma (BSCC) is a rare variant of squamous cell carcinoma with distinct pathologic characteristics. The histogenesis of BSCC is not fully understood, and the cancer has been suggested to originate from a totipotent primitive cell in the basal cell layer of the surface epithelium or in the proximal duct of secretory glands. METHODS: Twenty-six cases of head and neck BSCC from Asan Medical Center, Seoul, Korea, reported during a 14-year-period were subclassified into basal, ductal, and mixed subtypes according to the expression of basal (cytokeratin [CK] 5/6, p63) or ductal markers (CK7, CK8/18)...
July 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/28593742/overview-of-surgery-for-laryngeal-and-hypopharyngeal-cancer-in-ontario-2003-2010
#20
Antoine Eskander, Matthew Mifsud, Jonathan Irish, Patrick Gullane, Ralph Gilbert, Dale Brown, John R de Almeida, David R Urbach, David P Goldstein
BACKGROUND: The primary purpose of this study was to describe variations in incidence rates, resections rates, and types of surgical resection for patients diagnosed with laryngeal and hypopharyngeal cancers in Ontario. METHODS: All laryngeal and hypopharyngeal cancer cases in Ontario (2003-2010) were identified from the Ontario Cancer Registry (n = 3034). Variations in incidence rates, resection rates, and type of surgical resection were compared by sex, age group, neighborhood income, community population, health region, and physician specialty...
August 2017: Head & Neck
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