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Hypopharyngeal cancer

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https://www.readbyqxmd.com/read/28514762/novel-circular-rna-expression-profiles-reflect-progression-of-patients-with-hypopharyngeal-squamous-cell-carcinoma
#1
Shengda Cao, Dongmin Wei, Xu Li, Jieyu Zhou, Wenming Li, Ye Qian, Zhanwang Wang, Guojun Li, Xinliang Pan, Dapeng Lei
Circular RNAs (circRNAs), a novel class of endogenous noncoding RNAs, have been shown to have important roles in a number of diseases, including several types of cancers. We hypothesized that circRNAs are involved in the pathogenesis of hypopharyngeal squamous cell carcinoma (HSCC). To test our hypothesis, we initially compared the expression profiles of circRNAs in 4 paired HSCC and adjacent normal tissue samples by using a circRNA microarray. The microarray data showed that 2392 circRNAs, including 1304 upregulated and 1088 downregulated circRNA transcripts, were significantly dysregulated in the HSCC tissues...
April 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28501947/current-status-of-superficial-pharyngeal-squamous-cell-carcinoma-in-japan
#2
Ryoko Rikitake, Mizuo Ando, Yuki Saito, Seiichi Yoshimoto, Tatsuya Yamasoba, Takahiro Higashi
BACKGROUND: To investigate the status and treatment of superficial pharyngeal squamous cell carcinoma in Japan. METHODS: We analyzed all cases diagnosed between 2011 and 2013, as recorded in the national database of hospital-based cancer registries. We extracted data on patient sex, age, tumor locations, histology, presentation routes, initial treatments, and TNM stages. Additionally, we compared the characteristics of pharyngeal carcinoma to those of esophageal cancer...
May 13, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28489236/histologic-correlation-of-vegf-and-cox-2-expression-with-tumor-size-in-squamous-cell-carcinoma-of-the-larynx-and-hypopharynx
#3
Rodrigo Gonzalez Bonhin, Guilherme Machado de Carvalho, Alexandre Caixeta Guimarães, Vanessa Brito Rocha, Carlos Takahiro Chone, Agrício Nubiato Crespo, Eliane Maria Amstalden
The prognosis and survival of patients with laryngeal and hypopharyngeal squamous cell carcinoma (SCC) are related to the clinical staging. Tumor growth and metastasis are closely related to angiogenesis. Vascular endothelial growth factor (VEGF) and cyclooxygenase 2 (COX-2) are intimately related to the angiogenic process in which the blood supply required for neoplastic evolution is ensured. Considering the contributions of VEGF and COX-2 to the formation, growth, and progression of primary tumors, as well as their metastasis, it has been thought that the expression of these two factors might be related to the size and/or aggressiveness of laryngeal and hypopharyngeal cancer...
April 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/28487500/time-course-differential-lncrna-and-mrna-expressions-in-radioresistant-hypopharyngeal-cancer-cells
#4
Jieyu Zhou, Shengda Cao, Wenming Li, Dongmin Wei, Zhentao Wang, Guojun Li, Xinliang Pan, Dapeng Lei
Radioresistance remains a major problem in the treatment of patients with hypopharyngeal squamous cell carcinoma (HSCC). Long noncoding RNAs (lncRNAs) have important roles in the development, invasion, and metastasis of various tumors, including HSCC, but little is known about the role of lncRNAs in cancer radioresistance. The aim of this study was to identify radioresistance-related lncRNAs and mRNAs in radioresistant (RS) hypopharyngeal cancer subclone RS-FaDu cells. In this study, we performed microarray analysis to find the differences in time-course lncRNA and mRNA expression profiles between RS-FaDu and parent FaDu cells after 4 Gy radiation therapy, whose reliability was confirmed by validation experiment...
April 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/28474378/transoral-laser-microsurgery-for-treatment-for-hypopharyngeal-cancer-in-211-patients
#5
Bernhard G Weiss, Friedrich Ihler, Hendrik A Wolff, Simon Schneider, Martin Canis, Wolfgang Steiner, Christian Welz
BACKGROUND: The oncologic and functional outcome of transoral laser microsurgery (TLM) for primary treatment of hypopharyngeal cancer was examined in a multimodal treatment concept. METHODS: Two hundred eleven patients with squamous cell carcinoma (SCC) of the hypopharynx (pT1-4a, pN0-2, M0) were treated by TLM +/- neck dissection (88%) +/- (chemo)radiotherapy ([C]RT; 51%). The majority of cases were advanced stages III and IVa (85%). RESULTS: The 5-year Kaplan-Meier estimates for local control after TLM were pT category-related 88...
May 5, 2017: Head & Neck
https://www.readbyqxmd.com/read/28473272/novel-application-of-a-rigid-curved-larygno-pharyngoscope-for-examination-and-treatment-of-hypopharyngeal-lesions
#6
Kenichi Watanabe, Daisuke Yamauchi, Yoshitaka Takanashi, Hiroshi Hidaka, Yukio Katori
In endoscopic laryngo-pharyngeal surgery (ELPS), a rigid curved laryngo-pharyngoscope, which was invented by Dr. Sato et al., is necessary to obtain excellent surgical view of both hypopharynx and even the entrance of the esophagus. We have used this instrument for the examination and treatment of several diseases other than cancer located in the hypopharynx, such as difficult-to-find buried fish bones, retropharyngeal abscess, and congenital pyriform sinus fistula. In the result, we could acquire better view of hypopharynx and completed the intended procedure safely, especially for uncovering difficult-to-find fish bone buried in the mucosa...
May 1, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/28470631/fdg-pet-ct-predicts-survival-and-lung-metastasis-of-hypopharyngeal-cancer-in-a-multi-institutional-retrospective-study
#7
Hidenori Suzuki, Katsuhiko Kato, Masami Nishio, Tsuneo Tamaki, Yasushi Fujimoto, Mariko Hiramatsu, Nobuhiro Hanai, Takeshi Kodaira, Yoshiyuki Itoh, Shinji Naganawa, Michihiko Sone, Yasuhisa Hasegawa
OBJECTIVES: We investigated a possible correlation between the maximum standardized uptake value (SUVmax), which is assessed by pretreatment (18)F-fluorodeoxyglucose positron emission tomography with computed tomography, and the overall survival (OS) in patients with hypopharyngeal squamous cell carcinoma from two institutions on long-term follow-up, and examined whether SUVmax is correlated with several survival outcomes, including lung metastasis-free survival. METHODS: A total of 81 patients were enrolled...
May 3, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28430988/prognostic-significance-of-surgical-extranodal-extension-in-head-and-neck-squamous-cell-carcinoma-patients
#8
Fumihiko Matsumoto, Taisuke Mori, Satoko Matsumura, Yoshifumi Matsumoto, Masahiko Fukasawa, Masanori Teshima, Kenya Kobayashi, Seiichi Yoshimoto
Background: Lymph node metastasis with extranodal extension represents one of the most important adverse prognostic factors for survival in patients with head and neck squamous cell carcinoma. We propose that extranodal extension occurs to differing extents. The aim of this study was to determine the prognostic significance of extranodal extension in patients with head and neck squamous cell carcinoma. Methods: Two hundred and ninety-eight patients with head and neck squamous cell carcinoma who underwent surgical resection and neck dissection were included...
April 18, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28382514/intake-of-meat-and-fish-and-risk-of-head-neck-cancer-subtypes-in-the-netherlands-cohort-study
#9
Andy Perloy, Denise H E Maasland, Piet A van den Brandt, Bernd Kremer, Leo J Schouten
PURPOSE: To date, the role of meat and fish intake in head-neck cancer (HNC) etiology is not well understood and prospective evidence is limited. This prompted us to study the association between meat, fish, and HNC subtypes, i.e., oral cavity cancer (OCC), oro- and hypopharyngeal cancer (OHPC), and laryngeal cancer (LC), within the Netherlands Cohort Study (NLCS). METHODS: In 1986, 120,852 participants (aged 55-69 years) completed a baseline 150-item food frequency questionnaire (FFQ), from which daily meat and fish intake were calculated...
June 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28351574/the-impact-of-time-to-treatment-initiation-on-survival-from-head-and-neck-cancer-in-north-eastern-italy
#10
Jerry Polesel, Carlo Furlan, Silvia Birri, Vittorio Giacomarra, Emanuela Vaccher, Giuseppe Grando, Carlo Gobitti, Federico Navarria, Ornella Schioppa, Emilio Minatel, Ettore Bidoli, Luigi Barzan, Giovanni Franchin
OBJECTIVES: To evaluate the impact of time to treatment initiation (TTI) on overall survival in patients with head-and-neck squamous cell carcinoma (HNSCC). MATERIALS AND METHODS: In the period 2003-2009, 1616 HNSCC patients were diagnosed in Friuli Venezia Giulia Region, Northeastern Italy, including 462 oral, 346 oropharyngeal, 212 hypopharyngeal, and 596 laryngeal cancers. Clinical information, including date and type of first treatment, and follow-up were retrieved from the regional Cancer Registry and a population-based health database collecting comprehensive health information on people living in the Region...
April 2017: Oral Oncology
https://www.readbyqxmd.com/read/28325565/impact-of-the-method-and-success-of-pharyngeal-reconstruction-on-the-outcome-of-treating-laryngeal-and-hypopharyngeal-cancers-with-pharyngolaryngectomy-a-national-analysis
#11
S A R Nouraei, A Dias, H Kanona, D Vokes, P O'Flynn, P M Clarke, S E Middleton, A Darzi, P Aylin, N Jallali
BACKGROUND: Surgical treatment of cancers that arise from or invade the hypopharynx presents major reconstructive challenges. Reconstructive failure exposes the airway and neck vessels to digestive contents. METHODS: We performed a national N = near-all analysis of the administrative dataset to identify pharyngolaryngectomies in England between 2002 and 2012. Information about morbidity, pharyngeal closure method and post-operative complications was derived. RESULTS: There were 1589 predominantly male (78%) patients whose mean age at surgery was 62 years...
May 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28303058/-18f-fluorodeoxyglucose-uptake-by-positron-emission-tomography-predicts-outcomes-for-oropharyngeal-and-hypopharyngeal-cancer-treated-with-definitive-radiotherapy
#12
Takeaki Ishihara, Kazuhiro Kitajima, Yuko Suenaga, Yasuo Ejima, Hirokazu Komatsu, Naoki Otsuki, Ken-Ichi Nibu, Naomi Kiyota, Satoru Takahashi, Ryohei Sasaki
This study evaluated the prognostic significance of the maximum standardized uptake value of the primary site (pSUVmax) in 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) scans of patients with oropharyngeal or hypopharyngeal cancer who were treated using definitive radiotherapy. The study included 86 patients who were primarily treated with radiotherapy for oropharyngeal or hypopharyngeal cancer. Sixty-nine patients underwent concurrent chemotherapy. The associations between pre-treatment pSUVmax and treatment outcomes were evaluated...
February 2017: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/28301066/effect-of-daily-fraction-size-on-laryngoesophageal-dysfunction-after-chemoradiation-for-squamous-cell-carcinomas-of-the-larynx-and-hypopharynx
#13
Allen M Chen, Sophia Hsu, Jessica Meshman, Robert Chin, Philip Beron, Elliot Abemayor, Maie St John
BACKGROUND: The purpose of this study was to determine the effect of fraction size on laryngoesophageal dysfunction among patients treated by chemoradiotherapy for laryngeal and hypopharyngeal cancer. METHODS: Forty patients underwent chemoradiotherapy for stage III/IV squamous cell carcinomas of the larynx and hypopharynx. Median radiation dose was 70 Gy (range, 69.3-70.4 Gy) with daily fractionation ranging from 2 Gy to 2.2 Gy. RESULTS: When comparing 2 Gy versus >2 Gy daily fractionation, there was no difference in 2-year overall survival (71% vs 72%; p = ...
March 16, 2017: Head & Neck
https://www.readbyqxmd.com/read/28276321/downregulation-of-calcium-binding-protein-s100a9-inhibits-hypopharyngeal-cancer-cell-proliferation-and-invasion-ability-through-inactivation-of-nf%C3%AE%C2%BAb-signaling
#14
Ping Wu, Huatao Quan, Jing Kang, Jian He, Shi Luo, Chubo Xie, Jing Xu, Yaoyun Tang, Suping Zhao
Hypopharyngeal cancer (HPC) frequently present at an advanced stage, and display early submucosal spread, resulting inpoor prognosis, among the worst of all head and neck subsites. Detection of HPC at an earlier stage would be beneficial to patients. In this study, we used Differential in-gel electrophoresis (DIGE) and two-dimensional polyacrylamide gel electrophoresis (2-DE) proteomics analysis to indentify the potential biomarkers for HPC. Among the differential proteins identified, calcium binding protein S100A9 was overexpressed in HPC tissues compared with normal adjacent tissues, and S100A9 expression in metastatic tissues and advanced tumor tissues was higher than in non-metastatic tissues and early tumor tissues, respectively...
March 8, 2017: Oncology Research
https://www.readbyqxmd.com/read/28259450/modality-specific-target-definition-for-laryngeal-and-hypopharyngeal-cancer-on-fdg-pet-ct-and-mri
#15
Hans Ligtenberg, Elise Anne Jager, Joana Caldas-Magalhaes, Tim Schakel, Frank A Pameijer, Nicolien Kasperts, Stefan M Willems, Chris H J Terhaard, Cornelis P J Raaijmakers, Marielle E P Philippens
BACKGROUND AND PURPOSE: The goal of this study was to improve target definition by deriving modality-specific margins for clinical target volumes (CTV) for laryngeal and hypopharyngeal cancer on CT, MRI and 18-FDG-PET. MATERIAL AND METHODS: Twenty-five patients with T3/T4 laryngeal/hypopharyngeal cancer underwent CT, MRI and 18-FDG-PET scans before laryngectomy. HE-sections were obtained from the surgical specimen and tumor was delineated (tumorHE). The GTVs on CT and MRI were delineated in consensus...
March 1, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28239587/manoeuvres-to-improve-endoscopic-visualization-of-hypopharynx
#16
Pooja Thakur, V K Poorey
The more progress achieved in endoscopy, the more superficial cancers in head and neck region have been diagnosed. There are, however, some areas difficult to observe, particularly the hypopharynx, due to closure of this space. Examination of hypopharynx form an essential part of head and neck examination especially in the suspected malignancies as well as in the cases with unknown primary. As the flexible fiber-optic nasopharyngolaryngoscopy forms an essential part of examination of hypopharynx, the present study aims to evaluate the effectiveness of various manoeuvres devised to aid in better visualization of the hypopharynx...
March 2017: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/28225552/potential-clinical-significance-of-perioperative-levels-of-mrna-in-plasma-from-patients-with-cancer-of-the-larynx-or-hypopharynx
#17
Dolores C García-Olmo, J Diego Contreras, María G Picazo, Jesús López-Torres, Damián García-Olmo
BACKGROUND: The use of plasma as a "liquid biopsy" has gained increasing attention. The purpose of the present study was to evaluate the diagnostic and prognostic utility of the perioperative detection and quantitation of mRNAs encoding human telomerase reverse transcriptase (hTERT) and glyceraldehyde 3-phosphate dehydrogenase (GAPDH) in plasma from patients with cancer of the larynx or hypopharynx. METHODS: We recruited 47 patients with laryngeal cancer and 2 patients with hypopharyngeal cancer, plus 27 healthy subjects...
April 2017: Head & Neck
https://www.readbyqxmd.com/read/28195888/a-novel-application-of-double-paddle-peroneal-chimeric-flap-as-external-sentinel-monitor-in-hypopharyngeal-reconstruction
#18
Jung-Hua Hsueh, Yu-Hsuan Hsieh, Ying-Sheng Lin, Yaoh-Shiang Lin, Kuo-Chung Yang, Wen-Chung Liu
OBJECTIVES: Monitoring the viability of buried free flaps in hypopharyngeal reconstruction is difficult. Various methods have been proposed to monitor these buried flaps, but limitations remain. METHOD: We present a method of using double-paddle chimeric peroneal flaps that permanently externalizes a flap skin paddle as a monitoring paddle in hypopharyngeal reconstructions. This study was performed in a medical center in southern Taiwan; between 2013 and 2015, 10 patients underwent double-paddle chimeric peroneal flap reconstruction in advanced stages of hypopharyngeal cancer...
March 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28190450/transoral-laser-microsurgery-as-standard-approach-to-hypopharyngeal-cancer-survival-analysis-in-a-hospital-based-population
#19
Eduardo Breda, Raquel Catarino, Eurico Monteiro
OBJECTIVE: Cancer of the hypopharynx remains one of the most challenging chapters in head and neck oncology. The objective of this study is to ascertain the relevance of a transoral laser approach as a valid functional option for treatment of cancer of the hypopharynx in Portugal, and additionally, to confirm the reproducibility of survival and functional outcomes described in other reference centers. SUBJECTS AND METHODS: The outcomes of 37 out of 60 patients presenting hypopharyngeal carcinoma primarily treated by TLM (transoral laser microsurgery) and neck dissection and or adjuvant treatment when needed, with curative intention in tertiary referral center, were retrospectively evaluated and compared with published results...
February 10, 2017: Acta Otorrinolaringológica Española
https://www.readbyqxmd.com/read/28182816/a-13-year-single-institutional-experience-with-definitive-radiotherapy-in-hypopharyngeal-cancer
#20
LETTER
Kiattisa Sommat, Sook Kwin Yong, Kam Weng Fong, Terence Wk Tan, Joseph Ts Wee, Yoke Lim Soong
No abstract text is available yet for this article.
January 2017: Annals of the Academy of Medicine, Singapore
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